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https://www.readbyqxmd.com/read/28195257/pathological-complete-response-in-a-patient-affected-by-multiple-synchronous-breast-and-lung-primary-malignancies-a-case-report-and-review-of-the-literature
#1
A Nottegar, C Luchini, S Cingarlini, S Beccari, E Grego, E Gilioli, E Manfrin, F Bonetti
A pathological complete response in a patient affected by multiple synchronous, breast and lung primary malignancies is reported. A 63-year-old woman presented with an invasive ductal carcinoma of the breast and a lung adenocarcinoma. After multidisciplinary discussion, the patient underwent pulmonary left lower lobectomy followed by radio-chemotherapy with cisplatin and vinorelbine and started hormone therapy with letrozole. Ten months later, a left mastectomy with axillary lymph nodes dissection was performed...
December 2016: Pathologica
https://www.readbyqxmd.com/read/28193140/short-term-clinico-radiological-outcome-of-chronic-knee-synovitis-among-haemophilia-a-patients-post-phosphorus-32-radiosynoviorthesis
#2
Prasanna Ty, Jagadish Menon, Nataraj Ar, Dhanapathi Halanaik, Harshith Kramadhari
PURPOSE: Various modes of therapy have been directed at breaking the vicious cycle at early stage of synovitis in haemophilia patients. This study was planned to assess the short-term clinico-radiological outcome of chronic knee synovitis among haemophilia A patients post phosphorus-32 (P-32) radiosynoviorthesis. METHODS: P-32 samarium radiocolloid was injected into the knee and patients were followed up at 1 and 3 months, respectively. Clinical outcomes was assessed using Tegner Lysholm scores (TLSs), Modified Knee Society Clinical Rating System (MKSS) score and circumference of the knee joint...
January 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28188603/predictive-value-of-pre-treatment-apparent-diffusion-coefficient-adc-in-radio-chemiotherapy-treated-head-and-neck-squamous-cell-carcinoma
#3
Mariangela Lombardi, Teresa Cascone, Elena Guenzi, Alessandro Stecco, Francesco Buemi, Marco Krengli, Alessandro Carriero
OBJECTIVE: This study aimed at evaluating the role of "baseline" apparent diffusion coefficent (ADC), in patients affected by head and neck cancer treated with radio-chemotherapy, as a potential marker of response to therapy. METHODS: Fifty-seven patients underwent pretreatment ADC maps. Minimum, maximum, and medium ADC were computed. Age, dose, treatment time, and ADC values were compared between the two groups (Group 1: local control; Group 2: relapse/persistence of disease) using the Student t test two-tailed unpaired...
February 10, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28179287/possible-therapeutic-effects-of-ozone-mixture-on-hypoxia-in-tumor-development
#4
REVIEW
Margherita Luongo, Anna Lisa Brigida, Luigi Mascolo, Gennaro Gaudino
Recent literature highlights that ozone therapy could be considered a viable adjuvant therapy in oncological patients receiving radio-chemotherapy. The use of ozone therapy in these patients enhances the action of chemotherapy and at the same time reduces side-effects, such as nausea, vomiting, opportunistic infections, buccal ulcers, hair loss and fatigue. Such positive therapeutic effects of ozone therapy can cause a larger physical and mental wellbeing resulting in improved quality of life. This work reviews the recent acquisition of scientific knowledge regarding the ozone therapy and highlights the molecular and cellular pathways involved...
2017: Anticancer Research
https://www.readbyqxmd.com/read/28179157/the-influence-of-cell-and-nanoparticle-properties-on-heating-and-cell-death-in-a-radiofrequency-field
#5
Yuri Mackeyev, Colette Mark, Natasha Kumar, Rita E Serda
: The use of non-invasive radiofrequency (RF) energy to induce mild thermal and non-thermal effects in cancer tissue is under study as an adjuvant to chemo, radio or immuno therapy. This study examines cell specific sensitivities to RF exposure and the potential of nanoparticles to elevate heating rates or enhance biological effects. Increases in the heating rate of water in an RF field operating at 13.56MHz (0.004-0.028°C/s) were positively correlated with concentration of hybrid nanoparticles (1-10mg/ml) consisting of water soluble malonodiserinolamide [60]fullerene (C60-ser) conjugated to the surface of mesoporous silica nanoparticles (SiO2-C60)...
February 5, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28176976/the-importance-of-surgery-as-part-of-multimodal-therapy-in-rapid-progressive-primary-extraosseous-ewing-sarcoma-of-the-cervical-intra-and-epidural-space
#6
Richard Bostelmann, Mario Leimert, Hans Jakob Steiger, Kristin Gierga, Athanasios K Petridis
Primary extraosseous Ewing sarcomas (EESs) are an extremely rare pathological entity. Less than 32 cases have been reported in the literature. Here we report an uncommon case with very rapid progression in the cervical region with extra- and intradural involvement. We present a thorough review of the literature and discuss possible treatment modalities. The Medline database was searched using the search terms: Ewing sarcoma, extraosseus tumour, treatment, management, cervical spine. A previously healthy 29-year-old man complained of right-sided radiculopathy (C7)...
October 24, 2016: Clinics and Practice
https://www.readbyqxmd.com/read/28171697/eus-guided-tumor-ablation
#7
REVIEW
Sundeep Lakhtakia, Dong-Wan Seo
Real-time guidance of needle advancement has transformed Endoscopic Ultrasound from a diagnostic to an interventional procedure. EUS guided fine needle puncture has application in various interventional procedures (drainage of pseudocyst, biliary intervention, and injection of drugs). Celiac plexus or ganglion neurolysis for pain control is the major current EUS-guided fine-needle injection procedure. Feasibility and safety to accurately position needle devices and/or inject under real time EUS imaging with precise delivery of interventional agent have expanded the use of EUS to ablate tumor...
February 7, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28169355/enhancement-of-5-aminolevulinic-acid-based-fluorescence-detection-of-side-population-defined-glioma-stem-cells-by-iron-chelation
#8
Wenqian Wang, Kouichi Tabu, Yuichiro Hagiya, Yuta Sugiyama, Yasuhiro Kokubu, Yoshitaka Murota, Shun-Ichiro Ogura, Tetsuya Taga
Cancer stem cells (CSCs) are dominantly responsible for tumor progression and chemo/radio-resistance, resulting in tumor recurrence. 5-aminolevulinic acid (ALA) is metabolized to fluorescent protoporphyrin IX (PpIX) specifically in tumor cells, and therefore clinically used as a reagent for photodynamic diagnosis (PDD) and therapy (PDT) of cancers including gliomas. However, it remains to be clarified whether this method could be effective for CSC detection. Here, using flow cytometry-based analysis, we show that side population (SP)-defined C6 glioma CSCs (GSCs) displayed much less 5-ALA-derived PpIX fluorescence than non-GSCs...
February 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28169233/prophylactic-role-of-some-plants-and-phytochemicals-against-radio-genotoxicity-in-human-lymphocytes
#9
REVIEW
Mohsen Cheki, Ehsan Mihandoost, Alireza Shirazi, Aziz Mahmoudzadeh
Genotoxicity in lymphocytes of cancer patients undergoing radiotherapy can lead to lymphocytopenia. Lymphocytopenia induced by radiotherapy is one of the most unfavorable prognostic biological markers in cancer patients, since it has been accepted to be associated with poor prognosis in terms of both survival time and response to cancer therapy. Therefore, reduction in lymphocytopenia may increase treatment efficiency. Research endeavors with synthetic radioprotectors in the past have met with little success primarily due to toxicity-related problems...
October 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28163574/acne-vulgaris-perceptions-and-beliefs-of-saudi-adolescent-males
#10
Sahar H Al-Natour
INTRODUCTION: Although acne vulgaris is common in adolescents, information on their understanding of acne is minimal. OBJECTIVES: To evaluate the perceptions and beliefs of Saudi youth on acne. MATERIALS AND METHODS: Three hundred twenty-nine male students (aged 13-22 years) from 6 secondary schools in the Eastern Saudi Arabia completed a self-reported questionnaire on knowledge, causation, exacerbating and relieving factors of acne. Data were analyzed by SPSS version 15...
January 2017: Journal of Family & Community Medicine
https://www.readbyqxmd.com/read/28163466/angiolymphoid-hyperplasia-with-oeosinophilia-showing-promising-result-with-intralesional-radio-frequency-ablation-therapy-a-new-cost-effective-and-hassle-free-modality-of-treatment
#11
Chintaginjala Aruna, Senthil Kumar Alagappan, Ramamurthy Damaraju Venkata Satya Bhaskara, Sruthi Kondaveeti
No abstract text is available yet for this article.
October 2016: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/28155598/development-of-in-vitro-co-culture-model-in-anti-cancer-drug-development-cascade
#12
Ruiling Xu, Frances M. Richards
Tumour microenvironment is recognized as a major determinant of intrinsic resistance to anticancer therapies. In solid tumour types, such as breast cancer, lung cancer and pancreatic cancer, stromal components provide a fibrotic niche, which promotes stemness, EMT, chemo- and radio-resistance of tumour. However, this microenvironment is not recapitulated in the conventional cell monoculture or xenografts, hence these in vitro and in vivo preclinical models are unlikely to be predictive of clinical response; which might attribute to the poor predictivity of these preclinical drug-screening models...
1, 2017: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/28153347/impact-of-pulmonary-arterial-clot-location-on-pulmonary-embolism-treatment-and-outcomes-90%C3%A2-days
#13
C Charles Jain, Yuchiao Chang, Christopher Kabrhel, Jay Giri, Richard Channick, Josanna Rodriguez-Lopez, Rachel P Rosovsky, Annemarie Fogerty, Kenneth Rosenfield, Michael R Jaff, Ido Weinberg
Pulmonary embolism (PE) is common and management is based on risk stratification. The significance of clot location in submassive and massive PE is unclear. Data from a prospectively gathered database of submassive and massive PE were used for analysis. Available data included patient presentation, diagnostics, treatment, and outcome. Comparisons were made according to clot location: central or peripheral. A multivariable model was used for composite outcome of death or right ventricular (RV) strain at 90 days...
December 6, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/28150230/melanocortin-receptor-4-gene-polymorphisms-in-glioblastoma-patients-treated-with-concomitant-radio-chemotherapy
#14
Francesco Pasqualetti, Paola Orlandi, Vittorio Simeon, Martina Cantarella, Daniela Giuliani, Teresa Di Desidero, Alessandra Gonnelli, Durim Delishaj, Giuseppe Lombardi, Andrea Sechi, Marc Sanson, Vittorina Zagonel, Fabiola Paiar, Romano Danesi, Salvatore Guarini, Guido Bocci
Melanocortins are peptides with well-recognized antiinflammatory and neuroprotective activity. No data are currently available on melanocortin receptor-4 (MC4R) gene polymorphisms and tumors, including glioblastomas (GBMs), or their relationship with radiotherapy or chemotherapy. The aim of this study was to evaluate the possible predictive/prognostic role of the MC4R SNPs on GBM patients. Fifty-five patients with a proven diagnosis of GBM, treated with radiotherapy and temozolomide, were consecutively enrolled...
February 1, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28149332/the-immunomodulatory-anticancer-agent-rrx-001-induces-an-interferon-response-through-epigenetic-induction-of-viral-mimicry
#15
Hongjuan Zhao, Shoucheng Ning, Rosalie Nolley, Jan Scicinski, Bryan Oronsky, Susan J Knox, Donna M Peehl
BACKGROUND: RRx-001, a dinitroazetidine derivative, is a novel anticancer agent currently in phase II clinical trials. It mediates immunomodulatory effects either directly through polarization of tumor associated macrophages or indirectly through vascular normalization and increased T-lymphocyte infiltration. With multiple additional mechanisms of action including upregulation of oxidative stress, depletion of GSH and NADPH, anti-angiogenesis and epigenetic modulation, RRx-001 is being studied as a radio- and chemo-sensitizer to resensitize tumors to prior therapy and to prime tumors to respond to radiation, chemotherapy and immunotherapy in combination therapy studies...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28127177/prognostic-benefit-of-surgical-management-of-renal-cell-carcinoma-invading-the-inferior-vena-cava
#16
REVIEW
Aikaterini Mastoraki, Sotiria Mastoraki, Maria Tsikala-Vafea, Ioannis S Papanikolaou, Andreas Lazaris, Vassilios Smyrniotis, Nikolaos Arkadopoulos
Renal cell carcinoma (RCC) accounts for approximately 3 % of adult malignancies and 90-95 % of neoplasms arising from the kidney. One of the unique features of RCC is the tumor thrombus formation that migrates into the venous system including renal vein (RV) and inferior vena cava (IVC). Only 10 % of patients with RCC present with the classic triad of flank pain, hematuria and defined mass, while 25-30 % of affected patients are asymptomatic. Signs of para-neoplastic syndrome such as hypercalcemia, hypertension, anemia, cachexia and increased erythrocyte sedimentation rate (ESR) are often apparent...
March 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28124771/development-and-verification-of-a-time-delivery-model-for-prostate-intensity-modulated-radiotherapy-using-a-siemens-%C3%A2-artiste%C3%A2-160-multi-leaf-collimator-linac
#17
Nicola Fourie, Omer A Ali, William I D Rae
Time delivery models thus far proposed for prediction of radiotherapy delivery times are not applicable to all makes of Linac. Our purpose was to develop a time delivery model, which would also be applicable for a Siemens(®) ARTISTE™ 160 Multi-leaf Collimator (MLC) linear accelerator (Linac) and validate the model using prostate Intensity Modulated Radiation Therapy (IMRT) treatment plans. To our knowledge, a time delivery model has not yet been proposed for a Siemens(®) ARTISTE™ 160 MLC Linac. We used the principles of the time delivery model created for a Varian(®) Linac and added the radio frequency (RF) wave component, and the MLC delay time to the MLC travel time component...
January 26, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/28123916/stereotactic-body-radiotherapy-for-inoperable-liver-tumors-results-of-a-single-institutional-experience
#18
Hussam Hijazi, Marie-Pierre Campeau, David Roberge, David Donath, Real Lapointe, Franck Vandenbroucke-Menu, Daniel Taussky, Karim Boudam, Gabriel Chan, Alexis Bujold, Guila Delouya
OBJECTIVES: Stereotactic body radiation therapy (SBRT) is an emerging treatment option for liver tumors unsuitable for ablation or surgery. We report our experience with SBRT in the treatment of liver tumors. MATERIALS AND METHODS: Patients with primary or secondary liver cancer were identified in our local SBRT database. Patients were included irrespective of prior liver-directed therapies. The primary endpoint of our review was in-field local control (LC). Secondary endpoints were progression-free survival (PFS), overall survival (OS), and toxicity...
December 20, 2016: Curēus
https://www.readbyqxmd.com/read/28118995/idiopathic-pulmonary-fibrosis-current-and-future-directions
#19
E Soo, H Adamali, A J Edey
Idiopathic pulmonary fibrosis (IPF) is the most common idiopathic interstitial pneumonia and is increasingly recognised. Prior to the advent of effective therapies, achieving an early diagnosis was arguably of little prognostic consequence given IPF was considered an untreatable and uniformly fatal disease. The advent of new drug treatments has given hope for the future and raised the profile of IPF. International management guidelines highlight the critical role of radiology as part of an interstitial lung disease multidisciplinary team approach in reaching an accurate and early diagnosis of IPF...
January 21, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28117520/is-sentinel-node-biopsy-of-the-internal-mammary-lymph-nodes-relevant-in-the-management-of-breast-cancer
#20
Chuan Tan, Rebecca Caragata, Ian Bennett
The aim of this study was to review the outcomes of a series of breast cancer patients who underwent sentinel node biopsy inclusive of lymphoscintigraphy, and to assess the incidence of internal mammary node (IMN) metastatic positivity at exploration and whether these findings influenced treatment. Between April 2001 and December 2012, 581 breast cancer patients at Princess Alexandra Hospital underwent preoperative lymphoscintigraphy in the course of the performance of sentinel node biopsy. Analysis was performed of those patients who demonstrated radio-isotope uptake to the IMN chain, and who had sentinel node biopsy of the IMN's and were found to have metastatic involvement...
January 24, 2017: Breast Journal
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