Yin Wang, Yao Zou, Qingsong Jiang, Wenming Li, Xinyu Chai, Tingrui Zhao, Siyi Liu, Zhiyi Yuan, Chao Yu, Tingting Wang
Atherosclerosis is an inflammatory disease of blood vessels involving the immune system. Natural killer T (NKT) cells, as crucial components of the innate and acquired immune systems, play critical roles in the development of atherosclerosis. However, the mechanism and clinical relevance of NKT cells in early atherosclerosis are largely unclear. Our findings demonstrated that there were higher populations of NKT cells and interferon gamma (IFN-γ)-producing NKT cells in the peripheral blood of patients with hyperlipidemia and in the aorta, blood, spleen, and bone marrow of early atherosclerotic mice compared to control groups...
April 8, 2024: American Journal of Physiology. Cell Physiology