keyword
MENU ▼
Read by QxMD icon Read
search

oxidized low density lipoprotein

keyword
https://www.readbyqxmd.com/read/28230785/the-application-of-a-modified-d-roms-test-for-measurement-of-oxidative-stress-and-oxidized-high-density-lipoprotein
#1
Fumiaki Ito, Tomoyuki Ito, Chinatsu Suzuki, Tomoyo Yahata, Kazuyuki Ikeda, Kenji Hamaoka
Reactive oxygen species (ROS) are involved in the initiation and progression of atherosclerosis. ROS-derived hydroperoxides, as an indicator of ROS production, have been measured by using the diacron reactive oxygen metabolites (d-ROMs) test, which requires iron-containing transferrin in the reaction mixture. In this study we developed a modified d-ROMs test, termed the Fe-ROMs test, where iron ions were exogenously added to the reaction mixture. This modification is expected to exclude the assay variation that comes from different blood iron levels in individuals...
February 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28228702/catechin-treatment-ameliorates-diabetes-and-its-complications-in-streptozotocin-induced-diabetic-rats
#2
Saeed Samarghandian, Mohsen Azimi-Nezhad, Tahereh Farkhondeh
CONTEXT: Diabetes mellitus causes atherosclerosis and lipid abnormalities. Hypolipidemic and antioxidative properties of catechin (CTN) have been reported in several studies. OBJECTIVE: This study assesses the possible protective effects of CTN against oxidative damage in the diabetic rats. MATERIALS AND METHODS: The rats were divided into the control, untreated diabetic, and 3 CTN-treated diabetic groups (20, 40, and 80 mg/kg/d, intraperitoneal)...
January 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28225475/stretching-exercises-improve-vascular-endothelial-dysfunction-through-attenuation-of-oxidative-stress-in-chronic-heart-failure-patients-with-an-implantable-cardioverter-defibrillator
#3
Michitaka Kato, Takashi Masuda, Michio Ogano, Kazuki Hotta, Hisato Takagi, Shinya Tanaka, Yumi Kamada, Ayako Akiyama, Daisuke Kamekawa, Ryosuke Shimizu, Minoru Tabata, Jun Tanabe, Takuya Umemoto
PURPOSE: Endurance training improves oxidative stress and vascular endothelial dysfunction in patients with chronic heart failure (CHF). However, patients with CHF and an implantable cardioverter defibrillator (ICD) or cardiac resynchronization therapy-defibrillator (CRT-D) often avoid endurance training for fear of ICD shock. Recent studies have reported that stretching exercises enhance antioxidant activity and improve vascular responses. Therefore, we aimed to assess the effects of 4 weeks of stretching exercises on oxidative stress and vascular endothelial function in patients with CHF with an ICD or CRT-D...
March 2017: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/28224472/effects-of-weight-reduction-after-sleeve-gastrectomy-on-metabolic-variables-in-saudi-obese-subjects-in-aseer-province-of-kingdom-of-saudi-arabia
#4
Mohammed A Bawahab, Abdullah S Assiri, Walid Abdel Maksoud, Ayyub Patel, Osama Kadoumi, Gaffar Sarwar Zaman, Riyad Mohammed Khalil Alessih, Syed Saleem Haider
OBJECTIVES: The objectives of this study were to investigate the occurrence of oxidative stress, status of protective antioxidants enzymes, inflammatory biomarkers, and some metabolic health variables in the blood and to compare the results between those of the normal controls and obese patients submitted to sleeve gastrectomy-induced weight loss over a 1-year follow-up period. MATERIALS AND METHODS: A prospective study was conducted in Aseer Central Hospital and Abha Private Hospital in the Kingdom of Saudi Arabia from January 2012 to January 2013 on 50 normal (BMI = 22-25 kg/m(2)) control subjects and 50 obese (BMI = 45-50 kg/m(2)) patients...
February 21, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28224255/thiol-oxidase-ability-of-copper-ion-is-specifically-retained-upon-chelation-by-aldose-reductase
#5
Francesco Balestri, Roberta Moschini, Mario Cappiello, Umberto Mura, Antonella Del-Corso
Bovine lens aldose reductase is susceptible to a copper-mediated oxidation, leading to the generation of a disulfide bridge with the concomitant incorporation of two equivalents of the metal and inactivation of the enzyme. The metal complexed by the protein remains redox active, being able to catalyse the oxidation of different physiological thiol compounds. The thiol oxidase activity displayed by the enzymatic form carrying one equivalent of copper ion (Cu1-AR) has been characterized. The efficacy of Cu1-AR in catalysing thiol oxidation is essentially comparable to the free copper in terms of both thiol concentration and pH effect...
February 21, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28223350/mapping-atheroprotective-functions-and-related-proteins-lipoproteins-in-size-fractionated-human-plasma
#6
Debi K Swertfeger, Hailong Li, Sandra Rebholz, Xiaoting Zhu, Amy S Shah, W Sean Davidson, L Jason Lu
HDL has been shown to possess a variety of cardio-protective functions, including removal of excess cholesterol from the periphery, and inhibition of lipoprotein oxidation. It has been proposed that various HDL subparticles exist, each with distinct protein and lipid compositions, which may be responsible for HDL's many functions. We hypothesized that HDL functions will co-migrate with the operational lipoprotein subspecies when separated by gel filtration chromatography. Plasma from 10 healthy male donors was fractionated and the protein composition of the phospholipid containing fractions was analyzed by mass spectrometry (MS)...
February 21, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28223025/transcriptional-regulation-of-human-paraoxonase-1-by-nuclear-receptors
#7
REVIEW
N Ponce-Ruiz, F E Murillo-González, A E Rojas-García, Mike Mackness, Y Y Bernal-Hernández, B S Barrón-Vivanco, C A González-Arias, I M Medina-Díaz
Paraoxonase 1 (PON1) is a calcium-dependent esterase synthesized primarily in the liver and secreted into the plasma, where it is associates with high density lipoproteins (HDL). PON1 acts as antioxidant preventing low-density lipoprotein (LDL) oxidation which is believed to be critical in the initiation and progression of atherosclerosis. Additionally, PON1 hydrolyzes and detoxifies some toxic metabolites of organophosphorus compounds (OPs). Thus, PON1 activity and expression levels are important for determining susceptibility to OPs intoxication and risk of diseases related to inflammation and oxidative stress...
February 18, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28222394/pancreatoprotective-effects-of-geniotrigona-thoracica-stingless-bee-honey-in-streptozotocin-nicotinamide-induced-male-diabetic-rats
#8
Muhammad Shakir Abdul Aziz, Nelli Giribabu, Pasupuleti Visweswara Rao, Naguib Salleh
: Stingless bee honey (SLBH) has been claimed to possess multiple health benefits. Its anti-diabetic properties are however unknown. In this study, ability of SLBH from Geniotrigona thoracica stingless bee species in ameliorating pancreatic damage and in maintaining metabolic profiles were investigated in diabetic condition. METHODS: SLBH at 1 and 2g/kg/b.w. was given orally to streptozotocin (STZ)-nicotinamide-induced male diabetic rats for 28days. Metabolic parameters (fasting blood glucose-FBG and lipid profiles-LP and serum insulin) were measured by biochemical assays...
February 17, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28218579/effect-of-obstructive-sleep-apnea-on-carotid-artery-intima-media-thickness-related-to-inflammation
#9
Delei Kong, Zheng Qin, Wei Wang, Jian Kang
PURPOSE: Obstructive sleep apnea hypopnea syndrome (OSAHS) is an independent risk factor for atherosclerosis. To ascertain the effect of OSAHS on the development of atherosclerosis in Chinese OSAHS patients, we evaluated markers of atherosclerosis as well as vascular endothelial function and inflammation. METHODS: Chinese men with polysomnography-diagnosed OSAHS were subgrouped into mild-moderate (n = 28) and severe (n = 54) OSAHS groups on the basis of apnea hypopnea index (AHI) scores...
February 19, 2017: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/28217098/quercetin-inhibits-lps-induced-inflammation-and-ox-ldl-induced-lipid-deposition
#10
Feng Xue, Xiaobo Nie, Jianping Shi, Qingxue Liu, Ziwei Wang, Xiting Li, Jinqiu Zhou, Jia Su, Mingming Xue, Wei-Dong Chen, Yan-Dong Wang
Aberrant activation of inflammation and excess accumulation of lipids play crucial role in the occurrence and progression of atherosclerosis (AS). Quercetin (QCT) has been tested effectively to cure AS. It is widely distributed in plant foods and has been proved to have potential antioxidative and anticancer activities. However, the underlying molecular mechanisms of OCT in AS are not completely understood. In the present study, we stimulated murine RAW264.7 cells with lipopolysaccharide (LPS) or oxidized low-density lipoproteins (ox-LDL) to mimic the development of AS...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28215316/aronia-berry-polyphenol-consumption-reduces-plasma-total-and-low-density-lipoprotein-cholesterol-in-former-smokers-without-lowering-biomarkers-of-inflammation-and-oxidative-stress-a-randomized-controlled-trial
#11
Liyang Xie, Terrence Vance, Bohkyung Kim, Sang Gil Lee, Christian Caceres, Ying Wang, Patrice A Hubert, Ji-Young Lee, Ock K Chun, Bradley W Bolling
Former smokers are at increased risk for cardiovascular disease. We hypothesized that dietary aronia polyphenols would reduce biomarkers of cardiovascular disease risk, inflammation, and oxidative stress in former smokers. We also determined the extent these effects were associated with polyphenol bioavailability. A 12-week, randomized, placebo-controlled trial was conducted in 49 healthy adult former smokers (n = 24/placebo, n = 25/aronia) to evaluate if daily consumption of 500 mg aronia extract modulated plasma lipids, blood pressure, biomarkers of inflammation and oxidative stress, and lipid transport genes of peripheral blood mononuclear cells...
January 2017: Nutrition Research
https://www.readbyqxmd.com/read/28208754/gypenoside-xvii-prevents-atherosclerosis-by-attenuating-endothelial-apoptosis-and-oxidative-stress-insight-into-the-er%C3%AE-mediated-pi3k-akt-pathway
#12
Ke Yang, Haijing Zhang, Yun Luo, Jingyi Zhang, Min Wang, Ping Liao, Li Cao, Peng Guo, Guibo Sun, Xiaobo Sun
Phytoestrogens are estrogen-like compounds of plant origin. The pharmacological activities of phytoestrogens are predominantly due to their antioxidant, anti-inflammatory and lipid-lowering properties, which are mediated via the estrogen receptors (ERs): estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) and possibly G protein-coupled estrogen receptor 1 (GPER). Gypenoside XVII (GP-17) is a phytoestrogen that is widely used to prevent cardiovascular disease, including atherosclerosis, but the mechanism underlying these therapeutic effects is largely unclear...
February 9, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28208647/soy-leaf-extract-exerts-atheroprotective-effects-via-modulation-of-kr%C3%A3-ppel-like-factor-2-and-adhesion-molecules
#13
Jong-Min Han, Hua Li, Moon-Hee Cho, Seung-Hwa Baek, Chul-Ho Lee, Ho-Yong Park, Tae-Sook Jeong
Soy-leaf extracts exert their cardioprotective effects by inducing endothelium-dependent vasodilation in the arteries, and they favorably modulate the serum lipid profile. In this study, we investigated the atheroprotective effects of an ethanol extract of soy leaf (ESL) in human umbilical vein endothelial cells (HUVECs) and high-cholesterol diet (HCD)-fed low-density lipoprotein receptor deficient (LDLR-/-) mice. ESL induced the expression of Krüppel-like factor 2 (KLF2), an endothelial transcription factor, and endothelial nitric oxide synthase (eNOS), and suppressed the expression of vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) through moderate inflammatory signal activation, not only in tumor necrosis factor-α (TNF-α)-stimulated HUVECs but also in 7-ketocholesterol (7-KC)-stimulated HUVECs...
February 10, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28202546/identification-of-a-novel-series-of-anti-inflammatory-and-anti-oxidative-phospholipid-oxidation-products-containing-cyclopentenone-moiety-in-vitro-and-in-vivo-implication-in-atherosclerosis
#14
Jianhong Lu, Shuyuan Guo, Xinli Xue, Qun Chen, Jing Ge, Yujuan Zhuo, Huiqin Zhong, Buxing Chen, Mingming Zhao, Wei Han, Takashi Suzuki, Mingjiang Zhu, Lin Xia, Claus Schneider, Timothy S Blackwell, Ned A Porter, Lemin Zheng, Sotirios Tsimikas, Huiyong Yin
Oxidative stress and inflammation are two major contributing factors to atherosclerosis, a leading cause for cardiovascular diseases (CVDs). Oxidation of phospholipids on the surface of low density lipoprotein (LDL) particles generated under oxidative stress has been associated with the progression of atherosclerosis but the underlying molecular mechanisms remain poorly defined. We identified a novel series of oxidation products containing cyclopentenone moiety, termed deoxy-A2/J2-isoprostanes-phosphocholine (deoxy-A2/J2-IsoP-PC), from 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (PAPC) in vivo using mass spectrometry and by comparison to a chemically synthesized standard...
February 15, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28202387/varenicline-enhances-oxidized-ldl-uptake-by-increasing-expression-of-lox-1-and-cd36-scavenger-receptors-through-%C3%AE-7-nachr-in-macrophages
#15
Yuki Kanaoka, Mitsuhisa Koga, Keita Sugiyama, Kaoru Ohishi, Yasufumi Kataoka, Atsushi Yamauchi
Varenicline is a widely used and effective drug for smoking cessation. It is a partial agonist of the α4β2 nicotinic acetylcholine receptor (nAChR) and full agonist of α7 nAChR. We have reported that varenicline aggravates formation of atherosclerotic plaques through α7 nAChR in apolipoprotein E knockout mice. However, little is known about its effects on macrophages in atherosclerotic plaques. Here, we ascertained whether varenicline promotes oxidized low-density lipoprotein (oxLDL) uptake in mouse peritoneal macrophages in vitro and clarified its mechanism...
February 12, 2017: Toxicology
https://www.readbyqxmd.com/read/28198114/immunoaffinity-knockout-of-saponin-glycosides-from-asparagus-racemosus-to-assess-anti-lipid-peroxidation
#16
Churanya Onlom, Watoo Phrompittayarat, Waraporn Putalun, Neti Waranuch, Kornkanok Ingkaninan
INTRODUCTION: Asparagus racemosus Willd (Asparagaceae family), known as Shatavari, is important in Ayurveda and traditional Thai medicines. The saponin glycosides, shatavarin I and IV are major constituents in its roots and may be responsible for their actions including protection against lipid peroxidation and carcinogenesis. OBJECTIVE: To develop an immunoaffinity column for isolating compounds with structures related to shatavarin IV from crude extracts of A...
February 15, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28197300/long-term-treatment-of-native-ldl-induces-senescence-of-cultured-human-endothelial-cells
#17
Sung-Tack Oh, Hoon Park, Hyun Joong Yoon, Sung Yeul Yang
The study aimed to evaluate whether the treatment of primary cultured human endothelial cells with native low-density lipoprotein (nLDL) could induce their senescence and to uncover some of the putative mechanisms involved. For this purpose, human umbilical vein endothelial cells (HUVECs) were subcultured and/or continuously cultured with nLDL (0, 2, 5, and 10 μg protein/mL), for up to 9 days. The results indicated that nLDL inhibited the proliferation of HUVECs by arresting the cell cycle at G1 phase. The G1-arrested cells showed increase in cytosolic senescence-associated-β-galactosidase (SA-β-Gal) activity, a biomarker of cellular senescence...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28193797/mediterranean-diet-improves-high-density-lipoprotein-function-in-high-cardiovascular-risk-individuals-a-randomized-controlled-trial
#18
Álvaro Hernáez, Olga Castañer, Roberto Elosua, Xavier Pintó, Ramón Estruch, Jordi Salas-Salvadó, Dolores Corella, Fernando Arós, Lluis Serra-Majem, Miquel Fiol, Manuel Ortega-Calvo, Emilio Ros, Miguel Ángel Martínez-González, Rafael de la Torre, M Carmen López-Sabater, Montserrat Fitó
BACKGROUND: The biological functions of high-density lipoproteins (HDLs) contribute to explaining the cardioprotective role of the lipoprotein beyond quantitative HDL cholesterol levels. A few small-scale interventions with a single antioxidant have improved some HDL functions. However, to date, no long-term, large-scale, randomized controlled trial has been conducted to assess the effects of an antioxidant-rich dietary pattern (such as a traditional Mediterranean diet [TMD]) on HDL function in humans...
February 14, 2017: Circulation
https://www.readbyqxmd.com/read/28192229/hne-as-an-inducer-of-cox-2
#19
REVIEW
Koji Uchida
Cyclooxygenase-2 (COX-2), an inducible isoform responsible for high levels of prostaglandin (PG) production during inflammation and immune responses, mediate a variety of biological actions involved in vascular pathophysiology. COX-2 is induced by various stimuli, including proinflammatory cytokines, to result in PG synthesis associated with inflammation and carcinogenesis. 4-Hydroxy-2-nonenal (HNE) is one of a group of small molecules that can induce COX-2 expression. The mechanistic studies have revealed that the HNE-induced COX-2 expression results from the stabilization of COX-2 mRNA mediated by the p38 mitogen-activated protein kinase signaling pathway and uniquely requires a serum component, which is eventually identified to be modified low-density lipoproteins (LDLs), such as the oxidized form of LDLs...
February 9, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28191769/suppression-of-transforming-growth-factor-%C3%AE-signaling-delays-cellular-senescence-and-preserves-the-function-of-endothelial-cells-derived-from-human-pluripotent-stem-cells
#20
Hao Bai, Yongxing Gao, Dixie L Hoyle, Tao Cheng, Zack Z Wang
Transplantation of vascular cells derived from human pluripotent stem cells (hPSCs) offers an attractive noninvasive method for repairing the ischemic tissues and for preventing the progression of vascular diseases. Here, we found that in a serum-free condition, the proliferation rate of hPSC-derived endothelial cells is quickly decreased, accompanied with an increased cellular senescence, resulting in impaired gene expression of endothelial nitric oxide synthase (eNOS) and impaired vessel forming capability in vitro and in vivo...
February 2017: Stem Cells Translational Medicine
keyword
keyword
84435
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"