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oxidized low density lipoprotein

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https://www.readbyqxmd.com/read/28529180/structure-function-relationships-in-reconstituted-hdl-focus-on-antioxidative-activity-and-cholesterol-efflux-capacity
#1
Alexandre M O Cukier, Patrice Therond, Svetlana A Didichenko, Isabelle Guillas-Baudouin, M John Chapman, Samuel D Wright, Anatol Kontush
AIMS: High-density lipoprotein (HDL) contains multiple components that endow it with biological activities. Apolipoprotein A-I (apoA-I) and surface phospholipids contribute to these activities; however, structure-function relationships in HDL particles remain incompletely characterized. METHODS: Reconstituted HDLs (rHDLs) were prepared from apoA-I and soy phosphatidylcholine (PC) at molar ratios of 1:50, 1:100 and 1:150. Oxidative status of apoA-I was varied using controlled oxidation of Met112 residue...
May 18, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28528308/hyperlipidemia-is-involved-in-apoptosis-in-rat-submandibular-glands
#2
Koichiro Irie, Takaaki Tomofuji, Daisuke Ekuni, Tetsuji Azuma, Toshiki Yoneda, Yoshihiro Shimazaki, Manabu Morita
OBJECTIVE: The aim of the present study was to investigate the effects of hyperlipidemia on histological changes and apoptosis in submandibular glands using apolipoprotein E (apoE)-deficient rats. DESIGN: Histopathological findings related to induced apoptosis in the submandibular glands were compared between apoE-deficient rats (n=6; male; age, 16 weeks) and the corresponding wild-type rats (n=6). RESULTS: ApoE-deficient rats showed significantly higher plasma levels of oxidized low-density lipoprotein (LDL), total cholesterol, very LDL and LDL, and lower plasma levels of high-density lipoprotein when compared to control rats (P<0...
May 17, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28526381/medium-term-effect-of-sublingual-l-glutathione-supplementation-on-flow-mediated-dilation-in-subjects-with-cardiovascular-risk-factors
#3
Jonica Campolo, Stefano Bernardi, Lorena Cozzi, Silvia Rocchiccioli, Cinzia Dellanoce, Antonella Cecchettini, Annamaria Tonini, Marina Parolini, Benedetta De Chiara, Gianpaolo Micheloni, Gualtiero Pelosi, Claudio Passino, Cristina Giannattasio, Oberdan Parodi
OBJECTIVE: Supplementation of glutathione (GSH) may be a positive strategy to improve the endogenous antioxidant defense required to counteract many acute and chronic diseases. However, the efficacy of GSH treatment seems to be closely related to type of administration, degree of absorption, and increase of its concentrations. The aim of this study was to test a new sublingual formulation of L-GSH, which enters directly the systemic circulation, to assess its efficacy on circulating biochemical markers of hepatic metabolism, lipid profile, and oxidative stress and on peripheral vascular function compared with placebo in patients with cardiovascular risk factors (CVRF)...
June 2017: Nutrition
https://www.readbyqxmd.com/read/28522412/athero-inflammatory-nanotherapeutics-ferulic-acid-based-poly-anhydride-ester-nanoparticles-attenuate-foam-cell-formation-by-regulating-macrophage-lipogenesis-and-reactive-oxygen-species-generation
#4
Rebecca A Chmielowski, Dalia S Abdelhamid, Jonathan J Faig, Latrisha K Petersen, Carol R Gardner, Kathryn E Uhrich, Laurie B Joseph, Prabhas V Moghe
Enhanced bioactive anti-oxidant formulations are critical for treatment of inflammatory diseases, such as atherosclerosis. A hallmark of early atherosclerosis is the uptake of oxidized low density lipoprotein (oxLDL) by macrophages, which results in foam cell and plaque formation in the arterial wall. The hypolipidemic, anti-inflammatory, and antioxidative properties of polyphenol compounds make them attractive targets for treatment of atherosclerosis. However, high concentrations of antioxidants can reverse their anti-atheroprotective properties and cause oxidative stress within the artery...
May 15, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28513775/adiponectin-inhibits-oxidization-induced-differentiation-of-t-helper-cells-through-inhibiting-costimulatory-cd40-and-cd80
#5
Y Xiao, T Deng, Z Shang, D Wang
Adiponectin is a multifunctional adipokine that has several oligomeric forms in the blood stream, which broadly regulates innate and acquired immunity. Therefore, in this study, we aimed to observe the differentiation of T helper (Th) cells and expression of costimulatory signaling molecules affected by adiponectin. The mRNA and protein expression levels of adiponectin and its receptors in oxidized low density lipoprotein cholesterol-treated endothelial cells were assayed by real time PCR and immunofluorescence...
May 15, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28506805/hdl-abnormalities-in-familial-hypercholesterolemia-focus-on-biological-functions
#6
REVIEW
Shiva Ganjali, Amir Abbas Momtazi, Maciej Banach, Petri T Kovanen, Evan A Stein, Amirhossein Sahebkar
Although a selective strong elevation in the plasma level of low-density lipoprotein (LDL) cholesterol is the hallmark of familial hypercholesterolemia (FH), also other plasma lipoprotein and lipid subspecies are changed in these patients. Several studies in FH patients have pointed to the qualitative abnormalities of high-density lipoprotein (HDL) particles, including their triglyceride and sphingomyelin enrichment, reduced capacity to promote cholesterol efflux from macrophages, impaired anti-inflammatory and anti-oxidant activities, and reduced plasma levels of miRs regulating HDL-dependent cholesterol efflux from macrophage foam cells, typical of atherosclerotic lesions...
May 12, 2017: Progress in Lipid Research
https://www.readbyqxmd.com/read/28503322/changes-in-oxidized-ldl-during-a-half-marathon-in-athletes-with-spinal-cord-injuries
#7
Toshihito Mitsui, Tomoyuki Ito, Yusuke Sasaki, Takashi Kawasaki, Takeshi Nakamura, Yukihide Nishimura, Tatsuru Ibusuki, Yukiharu Higuchi, Sayoko Hosoe, Fumiaki Ito, Fumihiro Tajima
INTRODUCTION: We reported previously that exercise significantly increases plasma adrenaline and oxidized low-density lipoprotein (oxLDL) in healthy subjects but not in persons with spinal cord injury (SCI). Since oxLDL and adrenaline levels are associated with oxidant/antioxidant balance, and exercise training elicits production of reactive oxygen species, we elucidated the effects of exercise on adrenaline, oxidant/antioxidant balance and oxLDL in individuals with SCI. CASE PRESENTATION: Eight subjects with cervical spinal cord injury (CSCI) and nine subjects with lower lesion of SCI (lower SCI (LSCI)) participated in a wheelchair half marathon race, and blood samples were collected before (pre), immediately after (post) and 1 h after the race (post 1 h)...
2017: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/28503188/impact-of-8-week-linoleic-acid-intake-in-soy-oil-on-lp-pla2-activity-in-healthy-adults
#8
Minkyung Kim, Minjoo Kim, Ayoung Lee, Hye Jin Yoo, Jung Soo Her, Sun Ha Jee, Jong Ho Lee
BACKGROUND: No intervention follow-up study has examined the association between plasma n-6 polyunsaturated fatty acids (PUFAs) and lipoprotein-associated phospholipase A2 (Lp-PLA2), which is a risk factor for cardiovascular disease (CVD). We aimed to determine whether the administration of linoleic acid (LA, 18:2n-6) in soy oil affected Lp-PLA2 activity in healthy adults. METHODS: Self-reported healthy participants (n = 150) were randomly assigned to three groups: a low LA group, in which 10 mL soy oil was replaced with one apple; a medium LA group, in which the typical food intake was maintained; and a high LA group, in which 1/3 cup of cooked refined rice was replaced with 9...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28500763/cross-talk-between-enzymes-matrix-metalloproteinsese-2-and-9-and-regulatory-t-cell-immunity-in-the-global-burden-of-atherosclerosis
#9
Andrica Lekic, Zdrinko Brekalo, Ante Kvesic, Miljenko Kovacevic, Zdenka Baricev-Novakovic, Ivana Sutic, Aleksandar Bulog, Ingrid Sutic, Valentino Pavisic, Ines Mrakovcic-Sutić
Changes in immune and inflammatory responses may play a crucial role in the development and progression of atherosclerosis, as an autoimmune, chronic and progressive inflammatory disease. Immunological activity and vascular inflammation during atherosclerosis can be modulated by autoimmune responses against self-antigens, according to changeable risk factors (cholesterol, oxidized low-density lipoprotein (ox-LDL) in the vascular wall, fatty acids, etc.) and accompanied by accumulation of leucocytes and proinflammatory cytokines, which stimulate the transcription of matrix-metalloproteinases (MMPs), whose concentration are increased in foam cell rich regions...
May 13, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28498017/dietary-supplements-as-surrogate-of-mediterranean-diet-in-healthy-smoking-subjects
#10
Sonya Vasto, Giulia Accardi, Anna Aiello, Francesca Di Gaudio, Annalisa Barera, Serena Indelicato, Damiano Galimberti, Emilio Italiano, Roberto Monastero, Claudia Rizzo, Calogero Caruso, Giuseppina Candore
The interventions to slow ageing, favouring active life expectancy, represent the new perspectives in ageing investigation. Some mechanisms that delay or prevent the onset of ageing pathologies have been identified. Between them, a healthy lifestyle seems to reduce many risk factors. In particular, eating habits represent the most concrete, low cost way to act on ageing process. Mediterranean diet has received much attention since it has been consistently demonstrated its anti-oxidant and anti-inflammatory effects...
May 12, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28494104/prevalence-of-metabolic-syndrome-and-its-association-with-lifestyle-and-cardiovascular-biomarkers-among-postmenopausal-women-in-western-algeria
#11
Ali Khalfa, Amina Tiali, Lakhdar Zemour, Azzedine Fatah, Khedidja Mekki
OBJECTIVE: To evaluate the prevalence of metabolic syndrome (MetS), its components, and their relationship with lifestyle, inflammation, and oxidative stress among postmenopausal Algerian women. METHODS: A prospective cross-sectional survey was conducted among postmenopausal women at a clinic in Oran, Algeria, from March 1 to June 28, 2015. A diagnosis of MetS was made using the National Cholesterol Education Program Adult Treatment Panel III guidelines. Demographic, clinical, metabolic, inflammatory, dietary, and energy variables were assessed...
May 11, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28490783/multiple-biomarker-responses-serum-biochemistry-oxidative-stress-genotoxicity-and-histopathology-in-channa-punctatus-exposed-to-heavy-metal-loaded-waste-water
#12
Mehjbeen Javed, Md Irshad Ahmad, Nazura Usmani, Masood Ahmad
Experiments were conducted to investigate the health of fish Channa punctatus inhabiting heavy metal-loaded waste water. Heavy metals in the order of Fe > Mn > Zn > Co > Ni > Cu = Cr were present in the waste water. Gills had high metal load followed by liver and then kidney. Albumin, albumin to globulin (A:G) ratio, triglyceride, high density lipoprotein (HDL) and very low density lipoprotein (VLDL) were found to be lower but phospholipid, low density lipoprotein (LDL), total protein, lipid and cholesterol were higher as compared to the reference...
May 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28490250/effects-of-acrylamide-graded-doses-on-metallothioneins-i-and-ii-induction-and-dna-fragmentation-bochemical-and-histomorphological-changes-in-the-liver-of-adult-rats
#13
Imen Ghorbel, Awatef Elwej, Mariem Chaabene, Ons Boudawara, Rim Marrakchi, Kamel Jamoussi, Tahya Sellami Boudawara, Najiba Zeghal
The present study investigates the toxic effects of acrylamide (ACR) administered to rats at two doses on (i) oxidative stress and disruption of pro-oxidant/antioxidant balance in hepatic cells and (ii) its correlation with metallothioneins (MTs) genes expression, DNA damage and histomorphological changes. Treated rats with 20 and 40 mg/kg body weight of ACR led to an increase in malondialdehyde, hydrogen peroxide, advanced oxidation protein products, protein carbonyl levels as well as an alteration in the antioxidant status...
January 1, 2017: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/28488192/effects-of-dietary-green-tea-camellia-sinensis-l-supplementation-on-growth-performance-lipid-metabolism-and-antioxidant-status-in-a-sturgeon-hybrid-of-sterlet-huso-huso-%C3%A2-%C3%A2-%C3%A3-%C3%A2-acipenser-ruthenus-%C3%A2-fed-oxidized-fish-oil
#14
Soleiman Hasanpour, Amir Parviz Salati, Bahram Falahatkar, Hamid Mohammadi Azarm
Lipid content of diet is very susceptible to oxidation, especially when stored for a long time, so for evaluating protective effects of green tea in fish received oxidized oil, this study was done. Lipid content of diet was replaced by oxidized fish oil (OFO) in 0, 50, and 100%. Green tea extract (GTE) was added to diet in three levels, 0, 5, and 100 mg/kg giving a total of nine experimental diets. Two hundred and seventy sturgeon hybrid of Sterlet (Huso huso ♀ × Acipenser ruthenus ♂) with initial weight of 212...
May 10, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/28488174/characterization-of-apolipoprotein-c3-apo-c3-lna-dna-impurities-and-degradation-products-by-lc-ms-ms
#15
Olga V Friese, Justin B Sperry, Yan He, Liji Joseph, James A Carroll, Jason C Rouse
Apolipoprotein C3 (Apo C3) LNA/DNA gapmer was evaluated under various stress and formulation conditions for the purpose of its development as a potential biotherapeutic for low density lipoprotein (LDL) lowering. Using ion-pairing (IP) reversed-phase (RP) liquid chromatography ultra-high resolution (UHR) tandem mass spectrometry (IP-RPLC-MS/MS), a combination of accurate mass measurements and collision-induced dissociation enabled in-depth characterization of Apo C3 LNA/DNA oligonucleotide, in particular the inherent impurities following synthesis and degradation products after exposure to stress conditions...
May 9, 2017: AAPS Journal
https://www.readbyqxmd.com/read/28487946/ghrelin-suppresses-inflammation-in-huvecs-by-inhibiting-ubiquitin-mediated-uncoupling-protein%C3%A2-2-degradation
#16
Ruolan Zhang
Atherosclerosis is considered the major cause of heart attack, stroke and gangrene of the extremities, which is responsible for 50% of all mortality in Western countries. The pathogenesis and causes of atherosclerosis remain elusive. Recent studies highlight inflammation as a contributing factor for atherosclerosis in all stages of the disease process. In this study, we demonstrate that the treatment of human umbilical vein endothelial cells (HUVECs) with ghrelin inhibits the oxidized low-density lipoprotein (oxLDL)-induced inflammatory response, In addition, treatment with ghrelin led to the accumulation of uncoupling protein 2 (UCP2) in the cells, thus decreasing reactive oxygen species (ROS) generation...
June 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28482710/sod2-gene-polymorphism-and-response-of-oxidative-stress-parameters-in-young-wrestlersto-a-three-month-training
#17
Ewa Jówko, Dariusz Gierczuk, Igor Cieśliński, Jadwiga Kotowska
The aim of the study was to analyse the effect of Val 16Ala polymorphism in SOD2 gene on oxidative stress parameters and lipid profile of the blood during a three-month wrestling training. The study included 53 Polish young wrestlers. Blood samples were collected at the beginning of the program and following three months of the training. The list of analysed parameters included erythrocyte and serum activities of superoxide dismutase (SOD), whole blood glutathione peroxidase (GPx) activity, total glutathione (tGSH) level, concentration of lipid hydroperoxides (LHs), total antioxidant capacity (TAC) and creatine kinase (CK) activity in the serum, as well as lipid profile parameters: triglycerides (TG), total cholesterol (TC), high-density (HDL-C) and low-density lipoprotein cholesterol (LDL-C)...
May 8, 2017: Free Radical Research
https://www.readbyqxmd.com/read/28481377/effects-of-6-week-nordic-walking-training-on-body-composition-and-antioxidant-status-for-women-55-years-of-age
#18
Agata Cebula, Anna Katarzyna Tyka, Wanda Pilch, Zbigniew Szyguła, Tomasz Pałka, Katarzyna Sztafa-Cabała, Barbara Frączek, Aleksander Tyka
OBJECTIVES: This study examined the effects of 6-week Nordic walking (NW) workout with individually customized intensity, on the body composition, and oxidative stress biomarkers for women > 55 years of age. MATERIAL AND METHODS: Sixteen sedentary women (age 58.1±2.02 years old, body mass index (BMI) 26.74±2.72 kg/m2) worked out the NW 3 times/week over the 6-week period. Training intensity, which reflected the dominance of oxygen metabolism, was determined based on changes in physiological indicators during graded exercise on a treadmill (walking with poles)...
May 8, 2017: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/28480509/oxidized-low-density-lipoprotein-stimulates-epithelial-sodium-channels-in-endothelial-cells-of-mouse-thoracic-aorta
#19
Chen Liang, Qiu-Shi Wang, Xu Yang, Na Niu, Qing-Qing Hu, Bao-Long Zhang, Ming-Ming Wu, Chang-Jiang Yu, Xiao Chen, Bin-Lin Song, Zhi-Ren Zhang, He-Ping Ma
BACKGROUND AND PURPOSE: Epithelial sodium channel (ENaC) is expressed in endothelial cells and acts as a negative modulator of vasodilation. Oxidized low-density lipoprotein (ox-LDL) is a key pathological factor in endothelial dysfunction. The present study is to examine the role of ENaC in ox-LDL-induced endothelial dysfunction and its associated signal transduction pathway. EXPERIMENTAL APPROACH: Patch-clamp techniques combined with pharmacological approaches were used to examine ENaC activity in the endothelial cells of split-open mouse thoracic aorta...
May 8, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28475147/folic-acid-supplementation-delays-atherosclerotic-lesion-development-by-modulating-mcp1-and-vegf-dna-methylation-levels-in-vivo-and-in-vitro
#20
Shanshan Cui, Wen Li, Xin Lv, Pengyan Wang, Yuxia Gao, Guowei Huang
The pathogenesis of atherosclerosis has been partly acknowledged to result from aberrant epigenetic mechanisms. Accordingly, low folate levels are considered to be a contributing factor to promoting vascular disease because of deregulation of DNA methylation. We hypothesized that increasing the levels of folic acid may act via an epigenetic gene silencing mechanism to ameliorate atherosclerosis. Here, we investigated the atheroprotective effects of folic acid and the resultant methylation status in high-fat diet-fed ApoE knockout mice and in oxidized low-density lipoprotein-treated human umbilical vein endothelial cells...
May 5, 2017: International Journal of Molecular Sciences
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