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oxidized low density lipoprotein

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https://www.readbyqxmd.com/read/29330254/increased-levels-of-lectin-like-oxidized-low-density-lipoprotein-receptor-1-in-ischemic-stroke-and-transient-ischemic-attack
#1
Tonje Skarpengland, Mona Skjelland, Xiang Yi Kong, Karolina Skagen, Sverre Holm, Kari Otterdal, Christen P Dahl, Kirsten Krohg-Sørensen, Ellen L Sagen, Vigdis Bjerkeli, Anne Hege Aamodt, Azhar Abbas, Ida Gregersen, Pål Aukrust, Bente Halvorsen, Tuva B Dahl
BACKGROUND: Soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) has been shown to be increased in patients with acute ischemic stroke. Here, we evaluated plasma sLOX-1 levels and vascular carotid plaque LOX-1 (ie, OLR1) gene expression in patients with ischemic stroke and transient ischemic attack (TIA) with particular focus on their relation to time since symptom onset. METHODS AND RESULTS: Plasma sLOX-1 (n=232) and carotid plaque OLR1 gene expression (n=146) were evaluated in patients who were referred to evaluation for carotid endarterectomy, as well as in healthy control plasma (n=81)...
January 12, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29329335/immunization-with-gingipain-a-hemagglutinin-domain-of-porphyromonas-gingivalis-induces-igm-antibodies-binding-to-malondialdehyde-acetaldehyde-modified-low-density-lipoprotein
#2
Mikael Kyrklund, Outi Kummu, Jari Kankaanpää, Ramin Akhi, Antti Nissinen, S Pauliina Turunen, Pirkko Pussinen, Chunguang Wang, Sohvi Hörkkö
Treatment of periodontitis has beneficial effects on systemic inflammation markers that relate to progression of atherosclerosis. We aimed to investigate whether immunization with A hemagglutinin domain (Rgp44) of Porphyromonas gingivalis (Pg), a major etiologic agent of periodontitis, would lead to an antibody response cross-reacting with oxidized low-density lipoprotein (OxLDL) and how it would affect the progression of atherosclerosis in low-density lipoprotein receptor-deficient (LDLR-/-) mice. The data revealed a prominent IgM but not IgG response to malondialdehyde-acetaldehyde modified LDL (MAA-LDL) after Rgp44 and Pg immunizations, implying that Rgp44/Pg and MAA adducts may share cross-reactive epitopes that prompt IgM antibody production and consequently confer atheroprotection...
2018: PloS One
https://www.readbyqxmd.com/read/29328911/western-diet-triggers-nlrp3-dependent-innate-immune-reprogramming
#3
Anette Christ, Patrick Günther, Mario A R Lauterbach, Peter Duewell, Debjani Biswas, Karin Pelka, Claus J Scholz, Marije Oosting, Kristian Haendler, Kevin Baßler, Kathrin Klee, Jonas Schulte-Schrepping, Thomas Ulas, Simone J C F M Moorlag, Vinod Kumar, Min Hi Park, Leo A B Joosten, Laszlo A Groh, Niels P Riksen, Terje Espevik, Andreas Schlitzer, Yang Li, Michael L Fitzgerald, Mihai G Netea, Joachim L Schultze, Eicke Latz
Long-term epigenetic reprogramming of innate immune cells in response to microbes, also termed "trained immunity," causes prolonged altered cellular functionality to protect from secondary infections. Here, we investigated whether sterile triggers of inflammation induce trained immunity and thereby influence innate immune responses. Western diet (WD) feeding of Ldlr-/- mice induced systemic inflammation, which was undetectable in serum soon after mice were shifted back to a chow diet (CD). In contrast, myeloid cell responses toward innate stimuli remained broadly augmented...
January 11, 2018: Cell
https://www.readbyqxmd.com/read/29328492/exosomes-derived-from-oxidized-ldl-stimulated-macrophages-attenuate-the-growth-and-tube-formation-of-endothelial-cells
#4
Chaoyang Huang, Yuan Huang, Yijiang Zhou, Wencheng Nie, Xiangyuan Pu, Xiaolei Xu, Jianhua Zhu
Oxidized low-density lipoprotein (oxLDL) has a critical role in the development of atherosclerosis. The participation of oxLDL‑stimulated macrophages has been well‑established in atherosclerosis, however the underlying mechanisms are unclear. Macrophage‑derived exosomes are actively released and are involved in numerous physiological and pathological processes. However, the function of exosomes secreted by oxLDL‑stimulated macrophages in atherosclerosis remains unknown. Exosomes from oxLDL‑treated macrophages and controls were co‑cultured with endothelial cells and the exosomes were taken up by endocytosis...
January 5, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29328474/inhibition-of-mir%C3%A2-34a-prevents-endothelial-cell-apoptosis-by-directly-targeting-hdac1-in-the-setting-of-atherosclerosis
#5
Yangwei Li, Kang Zhang, Wei Mao
Despite recent medical advances, atherosclerosis is a global burden accounting for numerous mortalities and hospital admissions. MicroRNAs (miRNAs/miRs) regulate cardiovascular biology and disease, but the role of microRNA‑34a in atherosclerosis remains unclear. In the present study, it was demonstrated that miR‑34a was highly expressed in atherosclerotic lesions and oxidized low‑density lipoprotein (Ox‑LDL)‑treated human aortic endothelial cells (HAECs) (atherosclerotic cell model) using reverse transcription‑quantitative polymerase chain reaction...
January 9, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29325301/-role-of-cd36-in-nonalcoholic-fatty-liver-disease
#6
Z Zhan, H Ren, M L Peng
Nonalcoholic fatty liver disease (NAFLD) includes nonalcoholic simple fatty liver, nonalcoholic steatohepatitis, liver cirrhosis, and liver cancer and is the most common liver disease in the world. The complex pathogenesis of NAFLD is a major concern among researchers. CD36 is a transmembrane glycoprotein that takes up fatty acid and binds to oxidized low-density lipoprotein in the liver, and therefore, it is involved in the development and progression of NAFLD. With reference to the latest research findings, this article reviews the association between CD36 and NAFLD and the role of CD36...
December 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/29323716/oxidative-burden-in-familial-hypercholesterolemia
#7
REVIEW
Hamid Mollazadeh, Federico Carbone, Fabrizio Montecucco, Matteo Pirro, Amirhossein Sahebkar
Familial hypercholesterolemia (FH) is a genetic disorder characterized by high serum levels of low-density lipoprotein cholesterol (LDL-c). FH is characterized by accelerated development of atherosclerosis and represents the most frequent hereditary cause of premature coronary heart disease. Mutations of the LDL receptor gene are the genetic signature of FH, resulting in abnormal levels of circulating LDLs. Moreover, FH promotes the generation of reactive oxygen species (ROS) which is another key mechanism involved in atherosclerosis development and progression...
January 11, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29323707/ox-ldl-induces-endothelial-cell-apoptosis-and-macrophage-migration-by-regulating-caveolin-1-phosphorylation
#8
Fei Lin, Likai Pei, Qingbin Zhang, Weizhong Han, Shiliang Jiang, Yanliang Lin, Bo Dong, Lianqun Cui, Min Li
Oxidative low-density lipoprotein (ox-LDL) is a risk factor for atherosclerosis. Ox-LDL leads to endothelial injury in the initial stage of atherosclerosis. In this study, we investigated the role of ox-LDL in endothelial injury and macrophage recruitment. We demonstrated that ox-LDL promoted a dose-dependent phosphorylation of caveolin-1 in human umbilical vein endothelial cells. Phosphorylated caveolin-1 increased ox-LDL uptake. Intracellular accumulation of ox-LDL induced NF-κB p65 phosphorylation, promoted HMGB1 translocation from nucleus to cytoplasm and cytochrome C release from mitochondria to cytoplasm, and activated caspase 3, resulting in cell apoptosis...
January 11, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29322359/expression-profiles-of-micrornas-in-oxidized-low-density-lipoprotein-stimulated-raw-264-7-cells
#9
Xiaokai Li, Siyuan Feng, Yi Luo, Keren Long, Zhenghao Lin, Jideng Ma, Anan Jiang, Long Jin, Qianzi Tang, Mingzhou Li, Xun Wang
Macrophage-derived foam cells were one of the hallmarks of atherosclerosis, and microRNAs played an important role in the formation of foam cells. In order to explore the roles of miRNA in the formation of foam cells, we investigated miRNA expression profiles in foam cells through high-throughput sequencing technology. A total of 84 miRNAs were differentially expressed between RAW 264.7 macrophages and foam cells induced by ox-LDL. Thirty miRNAs were upregulated and 54 miRNAs were downregulated. GO terms and KEGG pathways analysis revealed that the target genes of most of DE miRNAs were mainly enriched in "cell differentiation," "endocytosis," "MAPK signaling pathway," and "FoxO signaling pathway...
January 10, 2018: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/29318986/oxidative-status-and-lipid-profile-among-dogs-at-different-stages-of-visceral-leishmaniasis
#10
Mehmet Gültekin, Serdar Paşa, Kerem Ural, Canberk Balıkçı, Gamze Sevri Ekren Aşıcı, Gamze Gültekin
OBJECTIVE: The purpose of the study was to investigate the oxidative status and lipid profile among dogs at different stages of visceral leishmaniasis (VL). METHODS: Dogs with VL were divided into four groups according to the classification reported by the Leishvet group: stage I (n=9), stage II (n=11), stage III (n=6), and stage IV (n=6); these dogs were compared to healthy control dogs (n=14). The lipid profile [high-density lipoprotein (HDL), low-density lipoprotein (LDL), cholesterol, and triglyceride levels) and oxidative status [total antioxidant capacity (TAC), total oxidant status (TOS), and paraoxonase-1 (PON-1) activity] were evaluated...
December 2017: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/29318368/increased-levels-of-advanced-glycation-end-products-positively-correlate-with-iron-overload-and-oxidative-stress-markers-in-patients-with-%C3%AE-thalassemia-major
#11
Maryam Sadat Mirlohi, Hamid Yaghooti, Saeed Shirali, Ali Aminasnafi, Samaneh Olapour
The impaired biosynthesis of the β-globin chain in β-thalassemia leads to the accumulation of unpaired alpha globin chains, failure in hemoglobin formation, and iron overload due to frequent blood transfusion. Iron excess causes oxidative stress and massive tissue injuries. Advanced glycation end products (AGEs) are harmful agents, and their production accelerates in oxidative conditions. This study was conducted on 45 patients with major β-thalassemia who received frequent blood transfusions and chelation therapy and were compared to 40 healthy subjects...
January 9, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29316215/oxidized-low-density-lipoprotein-in-inflammation-driven-thrombosis
#12
Georg Obermayer, Taras Afonyushkin, Christoph J Binder
Thrombosis is the defining feature of the most prevalent causes of cardiovascular mortality, such as myocardial infarction, stroke and pulmonary artery embolism. While platelet activation as well as activation of the plasmatic coagulation system are the hallmarks of thrombus formation, inflammatory processes and the cellular responses involved are increasingly recognized as critical modulators of thrombosis. In the context of many chronic inflammatory diseases that are associated with a high thrombotic risk, oxidized lipoproteins represent a prominent sterile trigger of inflammation...
January 6, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29313753/compared-to-an-oatmeal-breakfast-two-eggs-day-increased-plasma-carotenoids-and-choline-without-increasing-trimethyl-amine-n-oxide-concentrations
#13
Amanda Missimer, Maria Luz Fernandez, Diana M DiMarco, Gregory H Norris, Christopher N Blesso, Ana Gabriela Murillo, Marcela Vergara-Jimenez, Bruno S Lemos, Isabel Medina-Vera, Olga V Malysheva, Marie A Caudill
BACKGROUND: Habitual consumption of eggs has been hypothesized to positively modify biomarkers of cardiovascular disease risk through proposed antioxidant properties. OBJECTIVES: To examine this relationship, 50 young, healthy men and women were enrolled into a randomized crossover clinical intervention. METHODS: Participants consumed either 2 eggs per day or one packet of oatmeal a day for 4 weeks, followed by a 3-week wash-out and crossed over to the alternate breakfast...
January 9, 2018: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/29310566/analysis-of-oxidative-stress-related-markers-in-critically-ill-polytrauma-patients-an-observational-prospective-single-center-study
#14
Mihai Sandesc, Alexandru Florin Rogobete, Ovidiu Horea Bedreag, Anca Dinu, Marius Papurica, Carmen Alina Cradigati, Mirela Sarandan, Sonia Elena Popovici, Lavinia Melania Bratu, Tiberiu Bratu, Adrian Tudor Stan, Dorel Sandesc
Critically ill polytrauma patients have increased production of free radicals (FRs) and consequent alterations in biochemical pathways, as well as disruption of cellular integrity, due to increased lipid peroxidation. The aim of this study was to investigate several biomarkers associated with increased oxidative stress in critically ill polytrauma patients, and to evaluate the effect of antioxidant treatment on the clinical outcome in these patients. A total of 67 polytrauma patients from an intensive care unit met the selection criteria...
January 9, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29304538/catestatin-prevents-macrophage-driven-atherosclerosis-but-not-arterial-injury-induced-neointimal-hyperplasia
#15
Miho Kojima, Nana Ozawa, Yusaku Mori, Yui Takahashi, Kaho Watanabe-Kominato, Remina Shirai, Rena Watanabe, Kengo Sato, Taka-Aki Matsuyama, Hatsue Ishibashi-Ueda, Shinji Koba, Youichi Kobayashi, Tsutomu Hirano, Takuya Watanabe
Catestatin, a catecholamine-release inhibitory peptide, has multiple cardiovascular activities. Conflicting results have been recently reported by increased or decreased plasma levels of catestatin in patients with coronary artery disease (CAD). However, there have been no previous reports regarding the effects of catestatin on arteriosclerosis. This study evaluated the vasoprotective effects of catestatin on human macrophages, human aortic smooth muscle cells (HASMCs) and human umbilical vein endothelial cells (HUVECs) in vitro, and aortic atherosclerosis and wire injury-induced femoral artery neointimal hyperplasia in apolipoprotein E-deficient (ApoE-/-) mice fed with a high-cholesterol diet...
January 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29301853/-pro-renin-receptor-inhibition-reprograms-hepatic-lipid-metabolism-and-protects-mice-from-diet-induced-obesity-and-hepatosteatosis
#16
Liwei Ren, Yuan Sun, Hong Lu, Dien Ye, Lijuan Han, Na Wang, Alan Daugherty, Furong Li, Miaomiao Wang, Fengting Su, Wenjun Tao, Jie Sun, Noam Zelcer, Adam E Mullick, Ah J Danser, Yizhou Jiang, Yongcheng He, Xiongzhong Ruan, Xifeng Lu
Rationale: An elevated level of plasma low-density lipoprotein (LDL) is an established risk factor for cardiovascular disease. Recently, we reported that the (pro)renin receptor ([P]RR) regulates LDL metabolism in vitro via the LDL receptor (LDLR) and SORT1, independently of the renin-angiotensin system. Objective: To investigate the physiological role of [P]RR in lipid metabolism in vivo. Methods and Results: We used N-Acetylgalactosamine (GalNAc) modified antisense oligonucleotides (ASO) to specifically inhibit hepatic [P]RR expression in C57BL/6J mice, and studied the consequences this has on lipid metabolism...
January 4, 2018: Circulation Research
https://www.readbyqxmd.com/read/29299890/comparison-of-the-effects-of-clofibrate-and-silafibrate-on-sperm-parameters-quality-and-sex-hormones-in-male-rats
#17
Masoud Delashoub, Mojtaba Ziaee, Arash Khorrami, Seyed Mahdi Banan-Khojasteh
PURPOSE: Fibrates are drugs widely used for the treatment of hyperlipidemic disorders. Previous studies on a novel analogue of clofibrate, called silafibrate, have shown good lipid lowering effects. This study was designed to assess the role of silafibrate as a peroxisome proliferator-activated receptors (PPARs) agonist on sperm health and spermatogenesis in adult male rats. MATERIAL AND METHODS: Seventy male Wistar rats were randomly allocated into 7 groups: Cl-10, Cl-20, and Cl-40 mg/kg/day (clofibrate); Si-10, Si-20, and Si-40 mg/kg/day (silafibrate); and C, control...
January 3, 2018: Urology Journal
https://www.readbyqxmd.com/read/29298511/chrysanthemum-indicum-inhibits-adipogenesis-and-activates-the-ampk-pathway-in-high-fat-diet-induced-obese-mice
#18
Sarmila Nepali, Ji-Yun Cha, Hyeon-Hui Ki, Hoon-Yeon Lee, Young-Ho Kim, Dae-Ki Kim, Bong-Joon Song, Young-Mi Lee
Chrysanthemum indicum (CI) is widely distributed in China and many parts of the tropical world, and has been reported to have antibacterial, antiviral, anti-oxidant and immunomodulatory effects, but no information is available on its effects on high fat diet (HFD)-induced obesity. This was undertaken to investigate the mechanism responsible for the effect of ethyl acetate fraction of CI (CIEA) on adipogenesis, in vitro and in vivo models of obesity. In the in vitro study, differentiating 3T3-L1 cells were treated with media to initiate differentiation (MDI) in the presence or absence of CIEA with different concentrations, and in the in vivo study, C57BL/6 mice were fed with HFD and administered CIEA daily for six weeks...
January 3, 2018: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29295851/proteomic-profiling-for-cardiovascular-biomarker-discovery-in-orthostatic-hypotension
#19
Madeleine Johansson, Fabrizio Ricci, Nay Aung, Richard Sutton, Olle Melander, Artur Fedorowski
Orthostatic hypotension (OH) has been linked with higher incidence of cardiovascular disease, but little is known about the mechanisms behind this association. We aimed to identify cardiovascular disease biomarkers associated with OH through a proteomic profiling approach. Seven hundred seventy-eight patients with unexplained syncope or orthostatic intolerance underwent head-up tilt test and supine blood samples. Of these, 220 met diagnostic criteria of OH, and 179 demonstrated normal hemodynamic response during head-up tilt test...
January 2, 2018: Hypertension
https://www.readbyqxmd.com/read/29290940/lysophosphatidylcholine-induces-cytotoxicity-apoptosis-and-il-8-production-of-human-endothelial-cells-related-mechanisms
#20
Mei-Chi Chang, Jang-Jaer Lee, Yi-Jane Chen, Szu-I Lin, Li-Deh Lin, Eric Jein-Wen Liou, Wei-Ling Huang, Chiu-Po Chan, Chi-Chia Huang, Jiiang-Huei Jeng
Increased levels of oxidized low-density lipoprotein oxLDL) are shown to elevate the risk of cardiovascular diseases such as atherosclerosis, thrombosis, stroke, and myocardial infarction. This is possibly due to the toxic effects of oxLDLs on vascular cells. Various oxLDLs including lysophosphatidylcholine (LPC) and 7-ketocholesterol injure vascular endothelial cells and stimulate inflammatory reaction. However the toxicity of LPC on endothelial cells is not clear. In this study, human endothelial cells were exposed to LPC...
December 5, 2017: Oncotarget
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