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https://www.readbyqxmd.com/read/29451017/assessing-quality-control-strategies-for-hba1c-measurements-from-a-patient-risk-perspective
#1
Curtis A Parvin, Nikola A Baumann
BACKGROUND: Current laboratory risk management principles emphasize the importance of assessing laboratory quality control (QC) practices in terms of the risk of patient harm. Limited practical guidance or examples on how to do this are available. METHODS: The patient risk model described in a published laboratory risk management guideline was combined with a recently reported approach to computing the predicted probability of patient harm to produce a risk management index (RMI) that compares the predicted probability of patient harm for a QC strategy to the acceptable probability of patient harm based on the expected severity of harm caused by an erroneously reported patient result...
February 1, 2018: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/29439502/an-improved-pansharpening-method-for-misaligned-panchromatic-and-multispectral-data
#2
Hui Li, Linhai Jing, Yunwei Tang, Haifeng Ding
Numerous pansharpening methods were proposed in recent decades for fusing low-spatial-resolution multispectral (MS) images with high-spatial-resolution (HSR) panchromatic (PAN) bands to produce fused HSR MS images, which are widely used in various remote sensing tasks. The effect of misregistration between MS and PAN bands on quality of fused products has gained much attention in recent years. An improved method for misaligned MS and PAN imagery is proposed, through two improvements made on a previously published method named RMI (reduce misalignment impact)...
February 11, 2018: Sensors
https://www.readbyqxmd.com/read/29350636/imaging-of-pediatric-foot-disorders
#3
Alfonso Reginelli, Anna Russo, Fabrizio Turrizziani, Roberto Picascia, Elisa Micheletti, Vittoria Galeazzi, Umberto Russo, Assunta Sica, Fabrizio Cioce, Alberto Aliprandi, Andrea Giovagnoni, Salvatore Cappabianca
Infants and children undergo imaging studies to evaluate a wide variety of congenital and acquired disorders. Imaging protocols have to consider the patient's comfort, level of anxiety, and smaller size. The first imaging study is usually made with plain radiographs. The routine radiographic examination of the foot includes the anteroposterior (AP), lateral, and oblique projections. Magnetic Resonance Imaging (RMI) provides excellent anatomic detail of cartilage, vasculature and soft tissue thanks to superior soft tissue contrast and spatial resolution, so is valuable in many cases...
January 19, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29238719/can-replacing-ca125-with-he4-in-risk-of-malignancy-indices-1-4-improve-diagnostic-performance-in-the-presurgical-assessment-of-adnexal-tumors
#4
Nabil Abdalla, Robert Piórkowski, Paweł Stanirowski, Krzysztof Cendrowski, Włodzimierz Sawicki
Aims: To assess whether replacing CA125 with HE4 in the classical formulas of risk of malignancy indices (RMIs) can improve diagnostic performance. Methods: For each of 312 patients with an adnexal mass, classical RMIs 1-4 were computed based on ultrasound score, menopausal status, and serum CA125 levels. Additionally, modified RMIs (mRMIs) 1-4 were recalculated by replacing CA125 with HE4. Results: Malignant pathology was diagnosed in 52 patients (16...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29156098/technical-note-penumbral-width-trimming-in-solid-lung-dose-profiles-for-0-9-and-1-5-t-mri-linac-prototypes
#5
Sarah J Alnaghy, Jarrad Begg, Trent Causer, Thahabah Alharthi, Laura Glaubes, Bin Dong, Armia George, Lois Holloway, Peter Metcalfe
PURPOSE: Longitudinal magnetic fields narrow beam penumbra and tighten lateral spread of secondary electrons in air cavities, including lung tissue. Gafchromic® EBT3 film was used to investigate differences between penumbra in solid water and solid lung, without a magnetic field (0 T) and with two field strengths (0.9 and 1.5 T). METHODS: The first prototype of the Australian MRI-linac consisted of a 1.5 T Siemens Sonata MRI and Varian industrial linatron (nominal 4 MV)...
November 20, 2017: Medical Physics
https://www.readbyqxmd.com/read/29128624/wernicke-korsakoff-syndrome-complicated-by-subacute-beriberi-neuropathy-in-an-alcoholic-patient
#6
Salvatore Di Marco, Laura Pilati, Filippo Brighina, Brigida Fierro, Giuseppe Cosentino
Thiamine (vitamin B1) deficiency is a common condition in alcohol abusers, which can lead to damage of both the peripheral and the central nervous systems. Here we describe the case of an alcoholic patient who presented with acute onset of ataxia, severe weakness of the four limbs, and hypoesthesia and dysesthesia of the distal portion of the upper and lower extremities. The clinical picture also included mental confusion and amnesia. A diagnosis of Wernicke-Korsakoff syndrome was made based on clinical symptoms and brain RMI findings...
November 8, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29120830/areca-betel-nut-chewing-practices-of-adults-and-health-behaviors-of-their-children-in-the-freely-associated-states-micronesia-findings-from-the-children-s-healthy-living-chl-program
#7
Yvette C Paulino, Reynolette Ettienne, Rachel Novotny, Lynne R Wilkens, Moria Shomour, Cecilia Sigrah, Shelley D Remengesau, Emihner L Johnson, Julia M Alfred, Daisy F Gilmatam
BACKGROUND: Chewing areca (betel) nut has been deemed carcinogenic. The practice has become a public health concern in Micronesia. The Children's Healthy Living (CHL) Program included an areca (betel) nut questionnaire in a survey of household characteristics in the Freely Associated States (FAS). This paper describes areca (betel) nut chewing practices of adults and the health behaviors of their children. METHODS: A cross-section of 1200 children (2-8 year-olds) and their caregivers in Chuuk, Kosrae, Pohnpei, Republic of Palau, Republic of the Marshall Islands (RMI), and Yap were recruited...
October 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/29027715/diagnostic-performance-of-human-epididymis-protein-4-compared-to-a-combination-of-biophysical-and-biochemical-markers-to-differentiate-ovarian-endometriosis-from-epithelial-ovarian-cancer-in-premenopausal-women
#8
Tanja Nikolova, Radomir Zivadinovic, Nina Evtimovska, Violeta Klisarovska, Marko Stanojevic, Jadranka Georgievska, Natasha Nikolova
AIM: This study is a comparison of human epididymis protein 4 (HE4) with cancer antigen 125 (CA125), using the Risk of Ovarian Malignancy Algorithm (ROMA), Copenhagen Index (CPH-I), Risk of Malignancy Index (RMI) and Morphology Index (MI) to differentiate ovarian endometriosis from epithelial ovarian cancer (EOC) in premenopausal women. METHODS: The study was performed at the University Clinic of Obstetrics and Gynecology in Skopje. One hundred and sixty-four premenopausal patients were divided into three study groups, including ovarian endometriosis (37), other benign pelvic masses (57) and EOCs (11), and a control group (59)...
October 13, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28990941/influence-of-coronary-calcification-patterns-on-hemodynamic-outcome-of-coronary-stenoses-and-remodeling
#9
Ahmet Demirkıran, Ozan Çakır, Adem Atıcı, Emre Aslanger, Cansu Akdeniz, Berrin Umman, Sabahattin Umman, Zehra Bugra, Murat Sezer
OBJECTIVE: The histological characteristics of plaque may affect the hemodynamic outcome of a given coronary stenosis. In particular, the potential effect of volumetric calcium content and the topographical distribution in the lesion segment on physiological outcome has not yet been investigated. The aim of this study was to identify any potential correlation between patterns of calcification and the fractional flow reserve (FFR) and the coronary remodeling index (RMI). METHODS: A total of 26 stable angina pectoris and 34 acute coronary syndrome patients without persistent ST-segment elevation constituted the study population...
October 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28877996/blm-and-slx4-play-opposing-roles-in-recombination-dependent-replication-at-human-telomeres
#10
Alexander P Sobinoff, Joshua Am Allen, Axel A Neumann, Sile F Yang, Monica E Walsh, Jeremy D Henson, Roger R Reddel, Hilda A Pickett
Alternative lengthening of telomeres (ALT) is a telomere lengthening pathway that predominates in aggressive tumors of mesenchymal origin; however, the underlying mechanism of telomere synthesis is not fully understood. Here, we show that the BLM-TOP3A-RMI (BTR) dissolvase complex is required for ALT-mediated telomere synthesis. We propose that recombination intermediates formed during strand invasion are processed by the BTR complex, initiating rapid and extensive POLD3-dependent telomere synthesis followed by dissolution, with no overall exchange of telomeric DNA...
October 2, 2017: EMBO Journal
https://www.readbyqxmd.com/read/28852831/uterine-intravascular-lymphoma-as-a-cause-of-fever-of-unknown-origin
#11
REVIEW
Jérôme Hadjadj, Hubert Nielly, Eve Piekarski, Wendy Cuccuini, Bénedicte Deau-Fischer, Muriel Hourseau, Khadija Benali, Claire Fieschi, Marc Aletti, Thomas Papo, Eric Oksenhendler, Lionel Galicier, David Boutboul
Primary intravascular large B cell lymphoma (IVL) remains a diagnostic challenge because of non-specific clinical, laboratory and imaging findings. The aim of the study was to analyse the major characteristics of IVL with uterine involvement. We retrospectively collected features of IVL with uterine involvement that was proven histologically or demonstrated by significant 18 FDG uptake on 18 FDG-PET/CT. Findings were compared to a comprehensive literature review. Five patients were identified. All of them were admitted for fever of unknown origin (FUO), with haemophagocytic lymphohistiocytosis in three cases...
November 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28806987/a-prospective-study-to-evaluate-the-risk-malignancy-index-and-its-diagnostic-implication-in-patients-with-suspected-ovarian-mass
#12
Santosh Kumar Dora, Atal Bihari Dandapat, Benudhar Pande, Jatindra Prasad Hota
BACKGROUND: There is no universal screening method for discrimination between benign and malignant adnexal masses yet. Various authors have tried tumor markers, imaging studies, cytology but no one yet is a definite method for screening of cancer ovary, for which a combined diagnostic modality has come to practice in form of RMI. With this background we conducted our study "Evaluation of risk malignancy index and its diagnostic value in patients with adnexal masses". METHODS: The aim of the study was to determine the effectiveness of risk of malignancy index (RMI-3) in preoperative discrimination between benign and malignant masses and also to reveal the most suitable cut off value...
August 14, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28755436/the-diagnostic-accuracy-of-haptoglobin-within-ovarian-cyst-fluid-as-a-potential-point-of-care-test-for-epithelial-ovarian-cancer-an-observational-study
#13
Aniza P Mahyuddin, Lin Liu, Chanqing Zhao, Kothandaraman Narasimhan, Manuel Salto-Tellez, Brendon Nghee Kheem Pang, Diana Gkeok Stzuan Lim, Loganath Annalamai, Jerry K Y Chan, Timothy Yong Kuei Lim, Arijit Biswas, Gregory Rice, Khalil Razvi, Mahesh Choolani
OBJECTIVE: To investigate haptoglobin within ovarian cyst fluid (OCF) as a diagnostic biomarker for epithelial ovarian cancer (EOC) and develop an in vitro diagnostic point-of-care device test (IVDPCT) for use in the operating theatre. DESIGN: Retrospective and prospective cohort study. SETTING: South-East-Asia. POPULATION: Women with suspicious ovarian cysts. METHODS: Proteomic, immunohistochemical and ELISA methods measured haptoglobin in OCF to differentiate benign and EOCs...
July 29, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28681397/infantile-hemangiomas-with-minimal-or-arrested-growth-associated-with-soft-tissue-hypertrophy-a-case-series-of-10-patients
#14
S Planas-Ciudad, E Roé Crespo, I Sánchez-Carpintero, I J Frieden, A Martín-Santiago, P Redondo Bellón, E Moreno Artero, E Osier, L Puig Sanz, E Baselga Torres
BACKGROUND: Infantile hemangiomas with minimal or arrested growth (IH-MAGs) are characterized by a proliferative component of <25% of its surface area. The co-occurrence of IH-MAGs and soft tissue anomalies is rare, and case series of this association are lacking. OBJECTIVE: We present 10 cases of IH-MAGs associated with soft tissue hypertrophy and describe their clinical features. METHODS: We reviewed all infantile hemangiomas with minimal or arrested growth seen between 2009 and 2016 in the dermatology clinic department at Hospital Santa Creu i Sant Pau, Barcelona...
July 5, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28664894/comparison-of-phantom-materials-for-use-in-quality-assurance-of-microbeam-radiation-therapy
#15
Matthew Cameron, Iwan Cornelius, Dean Cutajar, Jeremy Davis, Anatoly Rosenfeld, Michael Lerch, Susanna Guatelli
Microbeam radiation therapy (MRT) is a promising radiotherapy modality that uses arrays of spatially fractionated micrometre-sized beams of synchrotron radiation to irradiate tumours. Routine dosimetry quality assurance (QA) prior to treatment is necessary to identify any changes in beam condition from the treatment plan, and is undertaken using solid homogeneous phantoms. Solid phantoms are designed for, and routinely used in, megavoltage X-ray beam radiation therapy. These solid phantoms are not necessarily designed to be water-equivalent at low X-ray energies, and therefore may not be suitable for MRT QA...
July 1, 2017: Journal of Synchrotron Radiation
https://www.readbyqxmd.com/read/28657550/pre-treatment-patient-specific-stopping-power-by-combining-list-mode-proton-radiography-and-x-ray-ct
#16
Charles-Antoine Collins-Fekete, Sébastien Brousmiche, David C Hansen, Luc Beaulieu, Joao Seco
The relative stopping power (RSP) uncertainty is the largest contributor to the range uncertainty in proton therapy. The purpose of this work was to develop a systematic method that yields accurate and patient-specific RSPs by combining (1) pre-treatment x-ray CT and (2) daily proton radiography of the patient. The method was formulated as a penalized least squares optimization problem (argmin([Formula: see text])). The parameter A represents the cumulative path-length crossed by the proton in each material, separated by thresholding on the HU...
August 3, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28640342/applicability-of-geomechanical-classifications-for-estimation-of-strength-properties-in-brazilian-rock-masses
#17
Tatiana B Santos, Milene S Lana, Allan E M Santos, Larissa R C Silveira
Many authors have been proposed several correlation equations between geomechanical classifications and strength parameters. However, these correlation equations have been based in rock masses with different characteristics when compared to Brazilian rock masses. This paper aims to study the applicability of the geomechanical classifications to obtain strength parameters of three Brazilian rock masses. Four classification systems have been used; the Rock Mass Rating (RMR), the Rock Mass Quality (Q), the Geological Strength Index (GSI) and the Rock Mass Index (RMi)...
April 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28624831/chelerythrine-attenuates-renal-ischemia-reperfusion-induced-myocardial-injury-by-activating-cse-h2s-via-pkc-nf-%C3%AE%C2%BAb-pathway-in-diabetic-rats
#18
Bo Hu, Guangtao Xu, Yongxia Zheng, Fei Tong, Ping Qian, Xiaoyan Pan, Xinmei Zhou, Ruilin Shen
BACKGROUND/AIMS: Chelerythrine (CHE), a benzophenanthridine alkaloid, is a potent, selective, and cell-permeable protein kinase C (PKC) inhibitor. The purpose of the present study was to evaluate the effect of CHE on myocardial recovery after renal ischemia/reperfusion (I/R)-induced myocardial injury (RI/RMI) in a streptozocin (STZ)-induced diabetic rat model. METHODS: Diabetes mellitus (DM) rats preconditioned with CHE and D, L-propargylglycine (PAG) were subjected to renal I/R...
2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/28624007/cardiac-mri-left-ventricular-global-function-index-and-quantitative-late-gadolinium-enhancement-in-unrecognized-myocardial-infarction
#19
Patrick Krumm, Tanja Zitzelsberger, Melanie Weinmann, Stefanie Mangold, Dominik Rath, Konstantin Nikolaou, Meinrad Gawaz, Ulrich Kramer, Bernhard Daniel Klumpp
PURPOSE: To compare left ventricular global function index (LVGFI) and quantitative late gadolinium enhancement (LGE) in patients with unrecognized myocardial infarction (UMI), recognized myocardial infarction (RMI) and without myocardial infarction (MI). MATERIAL AND METHODS: Under waiver of the Institutional Review Board 235 patients (age 63.5±10.5years, 57 female) were retrospectively evaluated. All patients had undergone cardiac MRI at 1.5T for symptoms of CAD...
July 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28577881/gene-enriched-draft-genome-of-the-cattle-tick-rhipicephalus-microplus-assembly-by-the-hybrid-pacific-biosciences-illumina-approach-enabled-analysis-of-the-highly-repetitive-genome
#20
Roberto A Barrero, Felix D Guerrero, Michael Black, John McCooke, Brett Chapman, Faye Schilkey, Adalberto A Pérez de León, Robert J Miller, Sara Bruns, Jason Dobry, Galina Mikhaylenko, Keith Stormo, Callum Bell, Quanzhou Tao, Robert Bogden, Paula M Moolhuijzen, Adam Hunter, Matthew I Bellgard
The genome of the cattle tick Rhipicephalus microplus, an ectoparasite with global distribution, is estimated to be 7.1Gbp in length and consists of approximately 70% repetitive DNA. We report the draft assembly of a tick genome that utilized a hybrid sequencing and assembly approach to capture the repetitive fractions of the genome. Our hybrid approach produced an assembly consisting of 2.0Gbp represented in 195,170 scaffolds with a N50 of 60,284bp. The Rmi v2.0 assembly is 51.46% repetitive with a large fraction of unclassified repeats, short interspersed elements, long interspersed elements and long terminal repeats...
June 1, 2017: International Journal for Parasitology
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