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https://www.readbyqxmd.com/read/28640342/applicability-of-geomechanical-classifications-for-estimation-of-strength-properties-in-brazilian-rock-masses
#1
Tatiana B Santos, Milene S Lana, Allan E M Santos, Larissa R C Silveira
Many authors have been proposed several correlation equations between geomechanical classifications and strength parameters. However, these correlation equations have been based in rock masses with different characteristics when compared to Brazilian rock masses. This paper aims to study the applicability of the geomechanical classifications to obtain strength parameters of three Brazilian rock masses. Four classification systems have been used; the Rock Mass Rating (RMR), the Rock Mass Quality (Q), the Geological Strength Index (GSI) and the Rock Mass Index (RMi)...
April 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28624831/chelerythrine-attenuates-renal-ischemia-reperfusion-induced-myocardial-injury-by-activating-cse-h2s-via-pkc-nf-%C3%AE%C2%BAb-pathway-in-diabetic-rats
#2
Bo Hu, Guangtao Xu, Yongxia Zheng, Fei Tong, Ping Qian, Xiaoyan Pan, Xinmei Zhou, Ruilin Shen
BACKGROUND/AIMS: Chelerythrine (CHE), a benzophenanthridine alkaloid, is a potent, selective, and cell-permeable protein kinase C (PKC) inhibitor. The purpose of the present study was to evaluate the effect of CHE on myocardial recovery after renal ischemia/reperfusion (I/R)-induced myocardial injury (RI/RMI) in a streptozocin (STZ)-induced diabetic rat model. METHODS: Diabetes mellitus (DM) rats preconditioned with CHE and D, L-propargylglycine (PAG) were subjected to renal I/R...
2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/28624007/cardiac-mri-left-ventricular-global-function-index-and-quantitative-late-gadolinium-enhancement-in-unrecognized-myocardial-infarction
#3
Patrick Krumm, Tanja Zitzelsberger, Melanie Weinmann, Stefanie Mangold, Dominik Rath, Konstantin Nikolaou, Meinrad Gawaz, Ulrich Kramer, Bernhard Daniel Klumpp
PURPOSE: To compare left ventricular global function index (LVGFI) and quantitative late gadolinium enhancement (LGE) in patients with unrecognized myocardial infarction (UMI), recognized myocardial infarction (RMI) and without myocardial infarction (MI). MATERIAL AND METHODS: Under waiver of the Institutional Review Board 235 patients (age 63.5±10.5years, 57 female) were retrospectively evaluated. All patients had undergone cardiac MRI at 1.5T for symptoms of CAD...
July 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28577881/gene-enriched-draft-genome-of-the-cattle-tick-rhipicephalus-microplus-assembly-by-the-hybrid-pacific-biosciences-illumina-approach-enabled-analysis-of-the-highly-repetitive-genome
#4
Roberto A Barrero, Felix D Guerrero, Michael Black, John McCooke, Brett Chapman, Faye Schilkey, Adalberto A Pérez de León, Robert J Miller, Sara Bruns, Jason Dobry, Galina Mikhaylenko, Keith Stormo, Callum Bell, Quanzhou Tao, Robert Bogden, Paula M Moolhuijzen, Adam Hunter, Matthew I Bellgard
The genome of the cattle tick Rhipicephalus microplus, an ectoparasite with global distribution, is estimated to be 7.1Gbp in length and consists of approximately 70% repetitive DNA. We report the draft assembly of a tick genome that utilized a hybrid sequencing and assembly approach to capture the repetitive fractions of the genome. Our hybrid approach produced an assembly consisting of 2.0Gbp represented in 195,170 scaffolds with a N50 of 60,284bp. The Rmi v2.0 assembly is 51.46% repetitive with a large fraction of unclassified repeats, short interspersed elements, long interspersed elements and long terminal repeats...
June 1, 2017: International Journal for Parasitology
https://www.readbyqxmd.com/read/28512173/clinical-utility-of-risk-models-to-refer-patients-with-adnexal-masses-to-specialized-oncology-care-multicenter-external-validation-using-decision-curve-analysis
#5
Laure Wynants, Dirk Timmerman, Jan Verbakel, Antonia Testa, Luca Savelli, Daniela Fischerová, Dorella Franchi, Caroline D Van Holsbeke, Elisabeth Epstein, Wouter Froyman, Stefano Guerriero, Alberto Rossi, Robert Fruscio, Francesco Leone, Tom Bourne, Lil Valentin, Ben Van Calster
To evaluate the utility of pre-operative diagnostic models for ovarian cancer based on ultrasound and/or biomarkers for referring patients to specialized oncology care. The investigated models were RMI, ROMA, and three models from the International Ovarian Tumor Analysis (IOTA) group (LR2, ADNEX, and the Simple Rules risk score, SRRisks). <p>DESIGN: A secondary analysis of prospectively collected data from two cross-sectional cohort studies performed to externally validate diagnostic models.</p> <p>PARTICIPANTS: A total of 2763 patients (2403 in dataset 1 and 360 in dataset 2) from 18 centers (11 oncology centers and 7 non-oncology hospitals) in 6 countries...
May 16, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28401542/quality-of-life-after-mastectomy-with-or-without-immediate-breast-reconstruction
#6
J Dauplat, F Kwiatkowski, P Rouanet, E Delay, K Clough, J L Verhaeghe, I Raoust, G Houvenaeghel, P Lemasurier, E Thivat, C Pomel
BACKGROUND: Mastectomy with immediate breast reconstruction (IBR) is a surgical strategy in breast cancer when breast-conserving surgery is not an option. There is a lack of evidence showing an advantage of mastectomy plus IBR over mastectomy alone on health-related quality of life (QoL). METHODS: A large prospective multicentre survey, STIC-RMI (support of innovative and expensive techniques - immediate breast reconstruction), was undertaken to study the changes in QoL in patients treated by mastectomy with or without IBR...
April 12, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28399913/the-readiness-and-motivation-interview-for-families-rmi-family-managing-pediatric-obesity-study-protocol
#7
Geoff D C Ball, Nicholas D Spence, Nadia E Browne, Kathleen O'Connor, Suja Srikameswaran, Joanna Zelichowska, Josephine Ho, Rebecca Gokiert, Louise C Mâsse, Valerie Carson, Katherine M Morrison, Jennifer L Kuk, Nicholas L Holt, Maryam Kebbe, Nicole D Gehring, Melody Cesar, Heidi Virtanen, Josie Geller
BACKGROUND: Experts recommend that clinicians assess motivational factors before initiating care for pediatric obesity. Currently, there are no well-established clinical tools available for assessing motivation in youth with obesity or their families. This represents an important gap in knowledge since motivation-related information may shed light on which patients might fail to complete treatment programs. Our study was designed to evaluate the measurement properties and utility of the Readiness and Motivational Interview for Families (RMI-Family), a structured interview that utilizes a motivational interviewing approach to (i) assess motivational factors in youth and their parents, and (ii) examine the degree to which motivation and motivation-related concordance between youth and parents are related to making changes to lifestyle habits for managing obesity in youth...
April 11, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28352483/ultrasound-echocardiography-mri-and-genetic-analysis-of-a-fetus-with-congenital-diaphragmatic-hernia-and-partial-11q-trisomy
#8
Yolanda Fernández-Perea, Lutgardo García-Díaz, Javier Sánchez, Guillermo Antiñolo, Salud Borrego
Congenital diaphragmatic hernia (CDH) is a serious birth defect with a significant mortality and morbidity. The current and constant progress in ultrasound techniques has led to the improvement of the prenatal diagnosis of this malformation. CDH is a developmental defect whose etiology is heterogeneous and takes place when the pleuroperitoneal folds and septum transversum fail to converge and fuse. Survival depends on the extent of pulmonary hypoplasia and the disease may be potentially worsened by the presence of added congenital defects...
2017: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28327296/local-diagnostic-reference-levels-for-intraoral-dental-radiography-in-the-public-hospitals-of-cyprus
#9
Stelios Christofides, Elina Pitri, Marios Lampaskis, Christos Papaefstathiou
PURPOSE: The purpose of this study was to determine local DRLs for children and adults undergoing intraoral dental examinations at the intraoral radiology units of the public hospitals in Cyprus. METHODS: Measurements were made on all the twenty intraoral X-ray units of the public hospitals in Cyprus with the intention to establish the local DRLs for all the possible intraoral X-ray examinations for children and adults. All units are film based. The measurements were made by a Dose Area Product (DAP) meter (GAMMEX RMI 841-RD) placed at the surface of the dental unit's X-ray shaping cone (FSD 20cm)...
November 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/28324147/genotoxicity-kinetics-in-murine-normoblasts-as-an-approach-for-the-in-vivo-action-of-difluorodeoxycytidine
#10
Pedro Morales-Ramírez, Teresita Vallarino-Kelly, Virginia Cruz-Vallejo
PURPOSE: This study analyzed the kinetics of in vivo micronucleus induction in normoblasts by determining the kinetics of difluorodeoxycytidine (dFdC)-induced micronucleated polychromatic erythrocytes (MN-PCEs) in the peripheral blood of mice. The kinetic indexes of MN-PCE induction of dFdC were correlated with the previously reported mechanisms DNA damage induction by this compound. In general, this study aimed to establish an in vivo approach for discerning the processes underlying micronucleus induction by antineoplastic agents or mutagens in general...
May 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28288666/reliability-of-preoperative-evaluation-of-postmenopausal-ovarian-tumors
#11
Riikka Johanna Niemi, Sami Kristian Saarelainen, Tiina Hannele Luukkaala, Johanna Unelma Mäenpää
BACKGROUND: Preoperative evaluation of ovarian tumors is challenging. This study was undertaken to evaluate the performance of conventional two-dimensional (2D) ultrasound and CA125 in predicting malignant or benign nature of pelvic masses, and to investigate if three-dimensional power Doppler (3DPD) ultrasound provides any added value. Ninety-six postmenopausal and four perimenopausal women with supposed ovarian tumors were examined by standardized 2D and 3DPD ultrasounds preoperatively...
March 14, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28228791/two-cases-of-pregnancy-and-lactation-associated-osteoporosis-successfully-treated-with-denosumab
#12
Ariel Sánchez, María Belén Zanchetta, Karina Danilowicz
Case 1. A 35-year-old woman in the 8(th) month of her first pregnancy suffered acute lumbar pain that persisted for 4 months. In the 5(th) month postpartum an acute increase in the low back pain led to a MRI which showed recent deformity in L1 and deformities of undetermined time of evolution in L2, L4, and L5. Laboratory evaluation did not reveal metabolic derangements. She had low bone mineral density (BMD, DXA) and severe deterioration of the microarchitecture of distal appendicular bone (HR-pQCT). Kyphoplasty of all 4 vertebrae was performed in 2 stages, and treatment with subcutaneous denosumab, 60 mg every 6 months, was begun...
September 2016: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/28152542/comparison-of-two-protocols-for-the-management-of-asymptomatic-postmenopausal-women-with-adnexal-tumours-a-randomised-controlled-trial-of-rmi-rcog-vs-simple-rules
#13
RANDOMIZED CONTROLLED TRIAL
Natalie Nunes, Gareth Ambler, Xulin Foo, Joel Naftalin, Grigoris Derdelis, Martin Widschwendter, Davor Jurkovic
BACKGROUND: Adnexal tumours are frequently diagnosed in asymptomatic postmenopausal women due to more liberal use of modern high-resolution imaging. This study's objective was to determine if there would be a difference in the intervention rates when using the Simple Rules Management Protocol (SRMP) as compared to the Risk of Malignancy Index in the Royal College of Obstetricians and Gynaecologists guideline (RMI/RCOG). METHODS: This was a prospective randomised controlled trial with the participants and the researchers non-blinded, and the surgeons and pathologists blinded...
February 28, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28126646/central-lobe-epilepsy-surgery-functional-results-and-how-to-evaluate-them
#14
Melissa van Offen, Peter C van Rijen, Frans S Leijten
OBJECT: To evaluate whether central lobe epilepsy (CLE) surgery in the pericentral area implies inevitable function loss and to determine how postsurgical functional outcomes are perceived by the patient. METHODS: We included all 22 people with epilepsy (PWE) who received central lobe epilepsy (CLE) surgery in the pre- and postcentral gyri between 1995 and 2015 in the University Medical Center Utrecht. We determined function loss and followed-up on quality of life (AQoL-8D), mobility (Rivermead Mobility Index RMI) and self-evaluation of the surgery...
February 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28104280/-robot-assisted-frykman-goldberg-procedure-case-report
#15
Gregorio Zubieta-O'Farrill, Moisés Ramírez-Ramírez, Eduardo Villanueva-Sáenz
BACKGROUND: Rectal prolapse is defined as the protrusion of the rectal wall through the anal canal; with a prevalence of less than 0.5%. The most frequent symptoms include pain, incomplete defecation sensation with blood and mucus, fecal incontinence and/or constipation. The surgical approach can be perineal or abdominal with the tendency for minimal invasion. Robot-assisted procedures are a novel option that offer technique advantages over open or laparoscopic approaches. CASE REPORT: 67 year-old female, who presented with rectal prolapse, posterior to an episode of constipation, that required manual reduction, associated with transanal hemorrhage during defecation and occasional fecal incontinence...
January 16, 2017: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/28087954/functional-limitation-and-health-related-quality-of-life-and-associated-factors-among-long-term-stroke-survivors-in-a-malaysian-community
#16
M N Nor Azlin, N A Aziz, B S Saperi, S M Aljunid
PURPOSE: this study aimed to evaluate function and quality of life (QoL) and associated factors among long term stroke survivors in the Malaysian community. METHODS: A cross-sectional study was conducted involving stroke survivors living in the community at two or more years post-stroke. Eligible participants with the diagnosis of stroke were identified from 2005-2010 case mix database of a tertiary hospital. the patients' medical records were analysed and data on demographic and clinical profiles were collected...
December 2016: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/28048636/tu-fg-brb-04-a-new-optimization-method-for-pre-treatment-patient-specific-stopping-power-by-combining-proton-radiography-and-x-ray-ct
#17
C Collins-Fekete, R Schulte, L Beaulieu, J Seco
PURPOSE: The relative stopping power (RSP) uncertainty is the largest contributor to the range uncertainty in proton therapy. The purpose of this work is to develop a robust and systematic method that yields accurate patient specific RSPs by combining pre-treatment X-ray CT and daily proton radiography. METHODS: The method is formulated as a penalized least squares optimization (PLSO) problem min(|Ax-B|). The matrix A represents the cumulative path-length crossed in each material computed by calculating proton trajectories through the X-ray CT...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047208/su-f-t-398-improving-radiotherapy-treatment-planning-using-dual-energy-computed-tomography-based-tissue-characterization
#18
N Tomic, H Bekerat, J Seuntjens, R Forghani, F DeBlois, S Devic
PURPOSE: Both kVp settings and geometric distribution of various materials lead to significant change of the HU values, showing the largest discrepancy for high-Z materials and for the lowest CT scanning kVp setting. On the other hand, the dose distributions around low-energy brachytherapy sources are highly dependent on the architecture and composition of tissue heterogeneities in and around the implant. Both measurements and Monte Carlo calculations show that improper tissue characterization may lead to calculated dose errors of 90% for low energy and around 10% for higher energy photons...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27956940/facilitating-the-interpretation-of-pedobarography-the-relative-midfoot-index-as-marker-for-pathologic-gait-in-ankle-osteoarthritic-and-contralateral-feet
#19
Frigg Arno, Frigg Roman, Wiewiorski Martin, Goldoni Jennifer, Horisberger Monika
BACKGROUND: Pedobarography offers dynamic information about the foot, but the interpretation of its large data is challenging. In a prior study it was shown that attention can be restricted to pedobarographic midfoot load data. We aim to verify this observation in ankle osteoarthritic and contralateral feet. METHODS: We assessed both feet of 120 patients with end-stage ankle osteoarthritis (OA) and 35 healthy volunteers with AOFAS-score and dynamic pedobarography in barefoot condition...
2016: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/27898751/-investigating-the-predictive-value-of-rmi-and-roma-indices-in-patients-with-ovarian-tumors-of-uncertain-dignity
#20
Géza Krascsenits, Boglárka Balázs, Anna Dudnyikova, Katalin Purcsi, Enikõ Orosz, Imre Pete
We were investigating the predictive value of RMI and ROMA indices in patients with ovarian tumors of uncertain dignity, in order to determine whether these methods are suitable for the early detection of ovarian malignancy. Our study included 162 patients treated at the Gynecological Department of the National Institute of Oncology (Budapest, Hungary). These patients were diagnosed with ovarian tumor of uncertain dignity, and were admitted to our Department with the purpose of gynecological surgery. Each of them had CA-125, HE4 blood tests and ultrasound scan in order to calculate RMI and ROMA indices and to study their effectiveness...
November 29, 2016: Magyar Onkologia
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