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Dress syndrome

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https://www.readbyqxmd.com/read/29226159/immunohistopathological-findings-of-severe-cutaneous-adverse-drug-reactions
#1
REVIEW
Mari Orime
Diagnosis of severe cutaneous adverse drug reactions should involve immunohistopathological examination, which gives insight into the pathomechanisms of these disorders. The characteristic histological findings of erythema multiforme (EM), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) provide conclusive evidence demonstrating that SJS/TEN can be distinguished from EM. Established SJS/TEN shows full-thickness, extensive keratinocyte necrosis that develops into subepidermal bullae. Drug-induced hypersensitivity syndrome (DIHS) and exanthema in drug reaction with eosinophilia and systemic symptoms (DRESS) each display a variety of histopathological findings, which may partly correlate with the clinical manifestations...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/29211168/burden-of-caregivers-of-children-and-adolescents-with-down-syndrome
#2
Alina Lúcia Oliveira Barros, Amanda Oliveira Barros, Geni Leda de Medeiros Barros, Maria Teresa Botti Rodrigues Santos
The aim of this study was to evaluate the profile and burden of caregivers of children/adolescents with and without Down syndrome. The evaluations were performed through questionnaires about the profile and burden of the caregivers (Zarit Burden Interview) and the profile of the children/adolescents. These questionnaires were applied to 168 caregivers. The chi-square test, Fisher's exact test, and analysis of variance were used with a significance level set at a = 5%. Both groups were composed of 84 participants, and the caregivers of the disabled group had a significantly higher percentage of females (p = 0...
November 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/29204346/drug-induced-hypersensitivity-syndrome-caused-by-valproic-acid-as-a-monotherapy-for-epilepsy-first-case-report-in-asian-population
#3
X T Wu, P W Hong, D J Suolang, D Zhou, H Stefan
Valproic acid (VPA) is a broad-spectrum antiseizure drug used for a variety of clinical conditions, such as epilepsy and mood disorders. Drug-induced hypersensitivity syndrome (DRESS) accompanied by hyponatremia, thrombocytopenia, hypoalbuminemia and elevated aminotransferase has never been reported as an adverse effect of VPA monotherapy during titration for epilepsy in Asian population. Hereby, we present the case of a 73-year-old Chinese male who suffered from DRESS and other complications two weeks after initiating VPA treatment for epilepsy...
2017: Epilepsy & Behavior Case Reports
https://www.readbyqxmd.com/read/29198698/successful-intravenous-immunoglobulin-treatment-in-pediatric-severe-dress-syndrome
#4
Nufar Marcus, Keren Smuel, Moran Almog, Dario Prais, Rachel Straussberg, Daniel Landau, Oded Scheuerman
BACKGROUND: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare, potentially life-threatening delayed drug-induced hypersensitivity reaction. The most frequently reported drugs causing DRESS are aromatic antiepileptic agents. Prompt withdrawal of the offending drug and administering systemic corticosteroids is the most widely accepted and used treatment. The treatment of severe DRESS not responsive to systemic corticosteroids is uncertain. OBJECTIVE: The objective of this study was to describe a case series of pediatric patients with DRESS who were treated successfully with intravenous immunoglobulins (IVIGs)...
November 30, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29172204/-primary-intracranial-malignant-lymphoma-associated-with-acquired-immunodeficiency-syndrome-aids-a-case-report
#5
Yasufumi Inaka, Naoki Otani, Sho Nishida, Kazuya Fujii, Hideaki Ueno, Satoshi Tomura, Arata Tomiyama, Hideo Osada, Kojiro Wada, Takuya Maeda, Kentaro Mori
The spread of human immunodeficiency virus(HIV)infection may result in an increased likelihood of surgery in patients with HIV infection. We treated a patient with intracranial malignant lymphoma associated with acquired immunodeficiency syndrome(AIDS)caused by HIV infection. The recommendations of the countermeasure manual for AIDS were followed. Only surgical staff without finger injury or inflammation were permitted to be involved in the operation. All staff were dressed in a waterproof, full-body surgical gown, and wore double gloves, double foot covers, and an N95 mask...
November 2017: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/29171940/human-leukocyte-antigens-key-regulators-of-t-cell-mediated-drug-hypersensitivity
#6
REVIEW
A J Redwood, R K Pavlos, K D White, E J Phillips
Adverse drug reactions (ADR) can be broadly categorised as either on-target or off-target. On-target ADRs arise as a direct consequence of the pharmacological properties of the drug and are therefore predictable and dose dependant. On-target ADRs comprise the majority (>80%) of ADRs, relate to the drug's interaction with its known pharmacological target and are a result of a complex interplay of genetic and ecologic factors. In contrast off-target ADRs, including immune mediated ADRs (IM-ADRs), are due to unintended pharmacological interactions such as inadvertent ligation of host cell receptors or non-pharmacological interactions mediated through an adaptive immune response...
November 24, 2017: HLA
https://www.readbyqxmd.com/read/29171464/-impact-of-various-wound-dressings-on-wound-bed-neoangiogenesis-in-patients-with-different-forms-of-diabetic-foot-syndrome
#7
E L Zaitseva, A Yu Tokmakova, L P Doronina, I A Voronkova, G R Galstyan, M V Shestakova
AIM: To investigate the impact of various wound dressings on wound bed neoangiogenesis in patients with different forms of diabetic foot syndrome (DFS). SUBJECTS AND METHODS: The clinical (local tissue oxygenation) and immunohistochemical (CD31) markers of foot soft tissue neoangiogenesis were evaluated in patients with DFS receiving negative pressure (NP) therapy and collagen-containing dressings (CCDs) versus standard treatment. 63 patients with neuropathic and neuroischemic (without critical ischemia) forms of DFS were examined after wound debridement...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/29150073/dress-syndrome-associated-with-splenic-thrombosis
#8
Nicole LaHood, Kristin Sokol
No abstract text is available yet for this article.
November 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29148000/the-feasibility-and-safety-of-piccs-accessed-via-the-superficial-femoral-vein-in-patients-with-superior-vena-cava-syndrome
#9
Yonghui Wan, Yuxin Chu, Yanru Qiu, Qian Chen, Wei Zhou, Qibin Song
OBJECTIVE: To investigate the feasibility and safety of the peripherally inserted central catheters (PICCs) accessed via the superficial femoral vein in patients with superior vena cava syndrome (SVCS). METHODS: From October 2010 to December 2014, 221 cancer patients with SVCS in our center received real-time ultrasound-guidance of the superficial femoral vein inserted central catheters (FICCs) at the mid-thigh. PICC insertion via upper extremity veins had also been investigated in 2604 cancer patients without SVCS as control...
November 10, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/29144034/considerations-in-surgical-management-of-a-buschke-lowenstein-tumor-in-netherton-syndrome-a-case-report
#10
Rosalind Ashton, Jamil Moledina, Branavan Sivakumar, Jemima E Mellerio, Anna E Martinez
Netherton syndrome is an autosomal recessive ichthyosis caused by mutations in SPINK5, with the classic triad of linearis circumflexa, trichorrhexis invaginata, and atopy. There are few reports of surgical management in individuals with Netherton syndrome and clinicians may be reluctant to operate for fear of wound-healing complications. This report describes a pediatric case of a Buschke-Lowenstein tumor of the natal cleft in a patient with Netherton syndrome that had failed to respond to medical management...
November 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29133221/drug-reaction-with-eosinophilia-and-systemic-symptoms-dress-syndrome-successfully-treated-with-mepolizumab
#11
Nikhita Ange, Sonia Alley, Suran L Fernando, Luke Coyle, James Yun
No abstract text is available yet for this article.
November 10, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29126664/fatal-dress-syndrome-under-tocilizumab-treatment-for-seronegative-polyarthritis
#12
Benoit Ben Said, Mathieu Gerfaud-Valentin, Pascal Seve
No abstract text is available yet for this article.
November 7, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29125944/hla-a-31-01-and-carbamazepine-induced-dress-syndrom-in-a-sample-of-north-african-population
#13
Kamilia Ksouda, Hanen Affes, Nedia Mahfoudh, Lassad Chtourou, Arwa Kammoun, Aida Charfi, Hend Chaabane, Molka Medhioub, Zouhir Sahnoun, Hamida Turki, Nabil Tahri, Serria Hammami, Khaled Zeghal
PURPOSE: Drug rash with eosinophilia and systemic symptoms (DRESS) is a serious adverse drug reaction. Carbamazepine is the most common causes of this syndrome. The HLA-A*31:01 allele has been shown to be strongly correlated with carbamazepine-induced DRESS syndrome in European, Japanese, Han Chinese and other asian population but not in African populations. So, our purpose is to study there is a correlation between HLA-A*31:01 and carbamazepine-induced DRESS syndrome in africain population? METHODS: HLA class I (A and B) typing was performed on 7 subjects with carbamazepine-DRESS syndrome and 25 tolerants controls subjects...
October 27, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29111803/dress-syndrome-triple-whammy-sulfasalazine-amoxicillin-and-hhv-7
#14
Michelle Lang, James Fish, Claudia Covelli, Benjamin E Schreiber
No abstract text is available yet for this article.
November 2, 2017: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/29102410/dress-syndrome-induced-by-ranitidine
#15
Timothy J Watts, Rubaiyat Haque
No abstract text is available yet for this article.
October 25, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29058836/-the-major-scar-syndromes
#16
G E Piérard, M Lesuisse, C Piérard-Franchimont
Some drug eruptions are frequent and follow an indolent course, while others prove to be life-threatening. By contrast, SCAR syndromes are serious skin drug reactions that are rare but their vital prognosis is affected. The three distinct entities of importance are the former Lyell's syndrome, now identified as SJS-TEN syndrome (Stevens-Johnson syndrome/toxic epidermal necrolysis), the DRESS syndrome (drug reaction with eosinophilia and systemic symptoms), and the AGEP syndrome (acute generalized exanthematous pustulosis)...
October 2017: Revue Médicale de Liège
https://www.readbyqxmd.com/read/29057181/allopurinol-induced-drug-reaction-with-eosinophilia-and-systemic-symptoms-syndrome-a-cause-of-acalculous-cholecystitis
#17
Husnain Waseem, Faisal Inayat, Madina Abduraimova, Stephan Kamholz
Acalculous cholecystitis (AC) is an inflammation of the gallbladder in the absence of gallstones. There are many risk factors associated with AC. However, this report implicates allopurinol as an inciting agent for a severe systemic drug reaction, i.e., the drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome complicated by AC. We report a Chinese woman who presented on two occasions with a diffuse maculopapular rash, elevated liver enzymes, and upper abdominal pain attributable to acute AC, the second episode of which developed after the reintroduction of allopurinol treatment for gout...
August 16, 2017: Curēus
https://www.readbyqxmd.com/read/29054953/vancomycin-associated-drug-reaction-with-eosinophilia-and-systemic-symptoms-dress-syndrome-masquerading-under-the-guise-of-sepsis
#18
Luke Maxfield, Toni Schlick, Angela Macri, James Thatcher
A patient presented with what appeared to be severe urosepsis. After admission and antibiotic administration, a newly developed rash and subsequent facial swelling appeared to be a reaction to penicillin class antibiotics. However, despite changing class of therapy with continued antimicrobial coverage, end organ damage continued, the rash worsened and facial oedema developed. Drug reaction with eosinophilia and systemic symptoms was ultimately diagnosed and was consistent with clinical and histopathological findings, as well as meeting all criteria for scoring systems...
October 19, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29041026/-toxic-shock-syndrome-caused-by-fingertip-injury-management-with-semi-occlusive-dressing
#19
Julia Sproedt, Abdul Rahman Jandali, Rotraud Katharina Saurenmann, Franziska Zucol
No abstract text is available yet for this article.
October 2017: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/29029855/improving-mortality-outcomes-of-stevens-johnson-syndrome-toxic-epidermal-necrolysis-a-regional-burns-centre-experience
#20
M Nizamoglu, J A Ward, Q Frew, H Gerrish, N Martin, A Shaw, D Barnes, O Shelly, B Philp, N El-Muttardi, P Dziewulski
INTRODUCTION: Stevens Johnson Syndrome/toxic epidermal necrolysis (SJS/TEN) are rare, potentially fatal desquamative disorders characterised by large areas of partial thickness skin and mucosal loss. The degree of epidermal detachment that occurs has led to SJS/TEN being described as a burn-like condition. These patients benefit from judicious critical care, early debridement and meticulous wound care. This is best undertaken within a multidisciplinary setting led by clinicians experienced in the management of massive skin loss and its sequelae...
October 10, 2017: Burns: Journal of the International Society for Burn Injuries
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