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https://www.readbyqxmd.com/read/28449404/changes-in-prescribing-and-healthcare-resource-utilization-after-fda-drug-safety-communications-involving-zolpidem-containing-medications
#1
Aaron S Kesselheim, Macarius Donneyong, Gerald J Dal Pan, Esther H Zhou, Jerry Avorn, Sebastian Schneeweiss, John D Seeger
PURPOSE: Products containing the sedative/hypnotic zolpidem were subject to Drug Safety Communications (DSCs) in January and May 2013 describing the risk of next-morning impairment and recommending lower starting doses particularly for women. This study aimed to assess whether zolpidem DSCs were associated with prescribing-pattern changes between January 2011 and December 2013. METHODS: We assessed overall dispensings of zolpidem-containing products between January 2011 and December 2013 by conducting a time-series analysis...
April 27, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28449397/differential-proteome-profiling-in-the-hippocampus-of-amnesic-mice
#2
Meghraj Singh Baghel, Mahendra Kumar Thakur
Amnesia or memory loss is associated with brain aging and several neurodegenerative pathologies including Alzheimer's disease (AD). This can be induced by a cholinergic antagonist scopolamine, but the underlying molecular mechanism is poorly understood. The present study of proteome profiling in the hippocampus could provide conceptual insights into the molecular mechanisms involved in amnesia. To reveal this, mice were administered scopolamine to induce amnesia and memory impairment was validated by novel object recognition test...
April 27, 2017: Hippocampus
https://www.readbyqxmd.com/read/28449325/electrosynthesis-of-bifunctional-ws3-x-rgo-hybrid-for-her-and-orr-electrocatalysis
#3
Martin Pumera
We combined the desirable properties of tungsten sulfide and reduced graphene oxide (rGO) and fabricated the hybrid materials through simultaneous electrochemical reduction and synthesis, as a versatile and environmentally benign alternative to conventional fabrication techniques. We synthesised a mixed WS2/WS3 film-like material (WS3-x) directly onto GO-modified glassy carbon electrodes via cyclic voltammetry (CV) and the resultant hybrid materials (WS3-x/rGO) were thoroughly characterised using scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS), X-ray photoelectron spectroscopy (XPS) as well as Raman spectroscopy...
April 27, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28449310/rational-design-of-nanobody80-loop-peptidomimetics-towards-biased-%C3%AE-2-adrenergic-receptor-ligands
#4
Charlotte Martin, Samuel Moors, Mia Danielsen, Cecilia Betti, Cecilia Fabris, Daniel Sejer Pedersen, Els Pardon, Marion Peyressatre, Krisztina Fehér, Jose C Martins, Jesper Mosolff Mathiesen, May Morris, Nick Devoogdt, Vicky Caveliers, Frank De Proft, Jan Steyaert, Steven Ballet
G protein-coupled receptors (GPCRs) play an important role for many cellular responses, and as such their mechanism of action is of utmost interest. To gain insight into the active conformation of GPCRs, the X-ray crystal structures of Nanobody(Nb)-stabilized β2-adrenergic receptor (β2AR) have been reported. Nb80 in particular is able to bind the intracellular G protein binding site of β2AR and stabilize the receptors in an active conformation. Within Nb80, the complementarity-determining region 3 (CDR3) is responsible for most of the binding interactions...
April 27, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28449298/all-silicon-switchable-magnetoelectric-effect-via-interlayer-exchange-coupling
#5
Hang Liu, Jia Tao Sun, Huixia Fu, Peijie Sun, Yuanping Feng, Sheng Meng
The magnetoelectric (ME) effect originating from the effective coupling between electric field and magnetism is an exciting frontier in nanoscale science such as magnetic tunneling junction (MTJ), ferroelectric/piezoelectric heterojunctions etc. The realization of switchable ME effect under external electric field in d^0 semiconducting materials of single composition is needed especially for all-silicon spintronics applications because of its natural compatibility with current industry. We employ the density functional theory (DFT) to reveal that the pristine Si(111)-√3×√3R30º (Si√3 hereafter) reconstructed surfaces of thin films with thickness smaller than eleven bilayers support sizeable linear ME effect with switchable direction of magnetic moment under external electric field...
April 27, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28449261/exploring-uncertainty-of-amazon-dieback-in-a-perturbed-parameter-earth-system-ensemble
#6
Chris A Boulton, Ben B B Booth, Peter Good
The future of the Amazon rainforest is unknown due to uncertainties in projected climate change and the response of the forest to this change (forest resiliency). Here we explore the effect of some uncertainties in climate and land surface processes on the future of the forest, using a perturbed physics ensemble of HadCM3C. This is the first time Amazon forest changes are presented using an ensemble exploring both land vegetation processes and physical climate feedbacks in a fully coupled modelling framework...
April 27, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28449245/characterization-of-a-poly-4-vinylpyridine-supported-cupd-bimetallic-catalyst-for-sonogashira-coupling-reactions
#7
Claudio Evangelisti, Antonella Balerna, Rinaldo Psaro, Graziano Fusini, Adriano Carpita, Maurizio Benfatto
CuPd bimetallic Solvated Metal Atoms (SMA) synthesized by metal vapor synthesis (MVS) technique and supported on poly-4-vinylpyridine (PVPy) resin, showed signicantly higher catalytic activity in Sonogashira-type carbon-carbon coupling reactions than the corresponding monometallic Cu and Pd systems as well as their physical mixture. The analysis of the bimetallic catalyst combining high-resolution transmission electron microscopy (HRTEM) and x-ray absorption ne structure (XAFS) spectroscopy revealed the presence of small Pd nanoparticles (dm = 2...
April 27, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28449188/development-validation-and-testing-of-a-skin-sampling-method-for-assessment-of-metal-exposure
#8
Behnaz Erfani, Klara Midander, Carola Lidén, Anneli Julander
BACKGROUND: Nickel, cobalt and chromium are frequent skin sensitizers. Skin exposure results in eczema in sensitized individuals, the risk being related to the skin dose. OBJECTIVES: To develop a self-sampling method for quantification of skin exposure to metals, to validate the method, and to assess its feasibility. METHODS: Defined metal doses (0.01-5 µg) were applied to the fingers of 5 participants. Skin areas (2 cm(2) ) were sampled with 1% HNO3 , either as 0...
April 27, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28449135/friendship-and-depression-among-couples-in-later-life-the-moderating-effects-of-marital-quality
#9
Sae Hwang Han, Kyungmin Kim, Jeffrey A Burr
Objectives: The aims of the study were to examine within-person associations between social interactions with friends (one's own and partner's) and depressive symptoms over time among couples in later life and to investigate whether marital quality moderated the associations. Methods: We used longitudinal data from the Health and Retirement Study (2004-2012) to examine a sample of coupled individuals (dyad N = 6,833). Dyadic growth curve models were employed to test the study hypotheses...
April 26, 2017: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/28449117/the-lxr-ligand-t0901317-acutely-inhibits-insulin-secretion-by-affecting-mitochondrial-metabolism
#10
Jonas Maczewsky, Jelena Sikimic, Cita Bauer, Peter Krippeit-Drews, Carmen Wolke, Uwe Lendeckel, Winfried Barthlen, Gisela Drews
The role of liver X receptor (LXR) in pancreatic beta-cell physiology and pathophysiology is still unclear. It has been postulated that chronic LXR activation in beta-cells induces lipotoxicity, a key step in the development of beta-cell dysfunction which accompanies type-2 diabetes mellitus. In most of these studies, the LXR ligand T0901317 has been administered chronically in the µmolar range to study the significance of LXR activation.In the present study, we have evaluated acute effects of T0901317 on stimulus-secretion coupling of beta-cells...
April 25, 2017: Endocrinology
https://www.readbyqxmd.com/read/28449107/the-role-of-dyadic-confidence-on-engagement-in-heart-failure-care-behaviors
#11
Karen S Lyons, Jill M Gelow, Shirin O Hiatt, James O Mudd, Jonathan Auld, Christopher V Chien, Christopher S Lee
Background and Objectives: Increasingly, older adults and their families are expected to manage complex conditions with little support. In the case of heart failure (HF), symptom monitoring and management are critical in preventing acute exacerbations and poor clinical outcomes. The current study examined the role of dyadic confidence on engagement in HF care behaviors by patients and their spouses. Research Design and Methods: A cross-sectional design was used to examine 60 couples living with HF...
April 26, 2017: Gerontologist
https://www.readbyqxmd.com/read/28449106/microbiomeanalyst-a-web-based-tool-for-comprehensive-statistical-visual-and-meta-analysis-of-microbiome-data
#12
Achal Dhariwal, Jasmine Chong, Salam Habib, Irah L King, Luis B Agellon, Jianguo Xia
The widespread application of next-generation sequencing technologies has revolutionized microbiome research by enabling high-throughput profiling of the genetic contents of microbial communities. How to analyze the resulting large complex datasets remains a key challenge in current microbiome studies. Over the past decade, powerful computational pipelines and robust protocols have been established to enable efficient raw data processing and annotation. The focus has shifted toward downstream statistical analysis and functional interpretation...
April 26, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28448907/characterization-of-typical-metal-particles-during-haze-episodes-in-shanghai-china
#13
Rui Li, Xin Yang, Hongbo Fu, Qingqing Hu, Liwu Zhang, Jianmin Chen
Aerosol particles were collected during three heavy haze episodes at Shanghai in the winter of 2013. Transmission electron microscopy (TEM) coupled with energy dispersive X-ray spectroscopy was used to study the morphology and speciation of typical metal particles at a single-particle level. In addition, time-of-flight aerosol mass spectrometry (ATOFMS) was applied to identify the speciation of the Fe-containing particles. TEM analysis indicated that various metal-containing particles were hosted by sulfates, nitrates, and oxides...
April 19, 2017: Chemosphere
https://www.readbyqxmd.com/read/28448903/violence-trauma-and-living-with-hiv-longitudinal-predictors-of-initiating-crystal-methamphetamine-injection-among-sex-workers
#14
Elena Argento, Steffanie A Strathdee, Shira Goldenberg, Melissa Braschel, Julio Montaner, Kate Shannon
BACKGROUND: Despite rapid increases in crystal methamphetamine (CM) use worldwide and established gendered patterns of use, empirical research on CM injection initiation among sex workers is limited. Given the wide range of harms associated with CM, alongside stimulant effects including sexual dis-inhibition and prolonged awake-ness, this study aimed to longitudinally investigate socio-structural predictors of initiating CM injection among sex workers in Vancouver, Canada. METHODS: Data (2010-2014) were drawn from a community-based cohort of women sex workers: AESHA (An Evaluation of Sex Workers Health Access)...
April 19, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28448890/metabolic-profiles-of-neotuberostemonine-and-tuberostemonine-in-rats-by-high-performance-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry
#15
Yongbin Tong, Weitong Xu, Yan Wu, Liting Ou, Mian Zhang, Xianghong Xu, Chaofeng Zhang
Neotuberostemonine (NS) and tuberostemonine (TS), a pair of stereoisomers, are the active components contained in Stemona tuberosa, an antitussive herbal medicine in China. Two isomers have different pharmacological efficacies, which will be related with their in vivo disposition. However, the metabolic fates of NS and TS remain unknown. A method of high performance liquid chromatography/quadrupole time-of-flight mass spectrometry coupled with mass detect filter technique was established to investigate the metabolites in rat plasma, bile, urine, and feces after oral administration of the equal doses of NS and TS...
April 17, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28448885/development-and-validation-of-a-liquid-chromatographic-method-for-the-analysis-of-squaric-acid-dibutyl-ester-and-its-impurities
#16
Marwa F Mansour, Peixi Zhu, Ann Van Schepdael, Erwin Adams
A simple, fast and selective stability indicating liquid chromatographic method has been described for the simultaneous determination of squaric acid dibutyl ester and its impurities. The chromatographic separation was achieved on a C2 column (250mm×4.6mm i.d., 5μm) using a mobile phase consisting of 0.15% phosphoric acid - acetonitrile - methanol (30:60:10, v/v/v). Isocratic elution was performed at a flow rate of 1.0mLmin(-1). The analytes were detected by UV at 252nm. The method was validated according to the ICH guidelines and satisfactory results were obtained...
April 18, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28448858/the-development-and-piloting-of-an-ehealth-breastfeeding-resource-targeting-fathers-and-partners-as-co-parents
#17
Jennifer Abbass-Dick, Fangli Xie, Jaymie Koroluk, Shelley Alcock Brillinger, Joanne Huizinga, Amber Newport, William M Goodman, Cindy-Lee Dennis
OBJECTIVE: Traditionally breastfeeding education programs target mothers solely. The objective of this study was to design and pilot test an interactive eHealth breastfeeding co-parenting resource developed to target both mothers and fathers. eHealth resources provide an accessible and engaging format on which to educate parents and assist them in meeting their breastfeeding goals. Best practices to design such resources are not currently known. DESIGN: A three phase pilot study was conducted...
April 18, 2017: Midwifery
https://www.readbyqxmd.com/read/28448834/cmc-prediction-for-ionic-surfactants-in-pure-water-and-aqueous-salt-solutions-based-solely-on-tabulated-molecular-parameters
#18
Stoyan I Karakashev, Stoyan K Smoukov
The critical micelle concentration (CMC) of various surfactants is difficult to predict accurately, yet often necessary to do in both industry and science. Hence, quantum-chemical software packages for precise calculation of CMC were developed, but they are expensive and time consuming. We show here an easy method for calculating CMC with a reasonable accuracy. Firstly, CMC0 (intrinsic CMC, absent added salt) was coupled with quantitative structure - property relationship (QSPR) with defined by us parameter "CMC predictor" f1...
April 18, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28448742/choreography-of-parental-histones-in-damaged-chromatin
#19
Juliette Dabin, Sophie E Polo
In the cell nucleus, DNA repair machineries operate on a chromatin substrate, whose integrity is key for preserving cell functions and identity. Yet, it is still unclear how the epigenetic information conveyed by chromatin is maintained during the DNA repair process. We recently characterized the dynamics of parental histones coupled to UV-C damage repair in human cells, providing insights into how the pre-damage chromatin state may be restored. Here, we summarize our main findings and discuss them in the context of epigenome maintenance following DNA damage...
February 23, 2017: Nucleus
https://www.readbyqxmd.com/read/28448738/site-specific-recruitment-of-epigenetic-factors-with-a-modular-crispr-cas-system
#20
Tobias Anton, Sebastian Bultmann
Dissecting the complex network of epigenetic modifications requires tools that combine precise recognition of DNA sequences with the capability to modify epigenetic marks. The CRISPR/Cas system has been proven to be a valuable addition to existing methodologies that fulfill these tasks. So far, sequence-specific editing of epigenetic modifications such as DNA methylation and histone posttranslational modifications relied on direct fusions of enzymatically inactivated Cas9 (dCas9) with epigenetic effectors. Here, we report a novel, modular system that facilitates the recruitment of any GFP-tagged protein to desired genomic loci...
February 23, 2017: Nucleus
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