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https://www.readbyqxmd.com/read/29169196/peroral-endoscopic-myotomy-in-treatment-na%C3%A3-ve-achalasia-patients-versus-prior-treatment-failure-cases
#1
Zaheer Nabi, Mohan Ramchandani, Radhika Chavan, Manu Tandan, Rakesh Kalapala, Santosh Darisetty, Sundeep Lakhtakia, G Venkat Rao, D Nageshwar Reddy
Background and study aim Peroral endoscopic myotomy (POEM) has emerged as an effective treatment modality for achalasia. Prior treatment may affect the outcomes of subsequent management. In this study, we aimed to compare the safety and efficacy of POEM in treatment-naïve patients vs. those with prior treatment failure (PTF). Patients and methods The data of consecutive patients with achalasia who underwent POEM at a single tertiary care center from January 2013 to November 2016 were analyzed retrospectively...
November 23, 2017: Endoscopy
https://www.readbyqxmd.com/read/29169162/application-of-electrocautery-needle-knife-combined-with-balloon-dilatation-versus-balloon-dilatation-in-the-treatment-of-tracheal-fibrotic-scar-stenosis
#2
Liyan Bo, Congcong Li, Min Chen, Deguang Mu, Faguang Jin
BACKGROUND: Electrocautery needle knives can largely reduce scar and granulation tissue hyperplasia and play an important role in treating patients with benign stricture. OBJECTIVE: The aim of this retrospective study was to evaluate the efficacy and safety of electrocautery needle knife combined with balloon dilatation versus balloon dilatation alone in the treatment of tracheal stenosis caused by tracheal intubation or tracheotomy. METHODS: We retrospectively analysed the clinical data of 43 patients with tracheal stenosis caused by tracheotomy or tracheal intubation in our department from January 2013 to January 2016...
November 23, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29169088/systematically-investigating-the-impact-of-medication-on-the-gut-microbiome
#3
REVIEW
Lisa Maier, Athanasios Typas
In the recent years, there is accumulating evidence for a strong impact of medication on the gut microbiota composition. This evidence comes from metagenomics-based associations and extends beyond classical antibacterials to a handful of human-targeted drugs. To answer whether such effects are direct and explore their consequences in human health, we need to develop experimental platforms that will allow for systematic profiling of drug-microbiota interactions. Here, we discuss approaches, considerations, experimental setups and strategies that can be used to tackle this need, but can be also readily transmitted to related questions in the microbiome field...
November 20, 2017: Current Opinion in Microbiology
https://www.readbyqxmd.com/read/29169082/the-safety-and-efficacy-of-propofol-as-a-replacement-for-amobarbital-in-intracarotid-wada-testing-of-presurgical-patients-with-epilepsy
#4
Kaci McCleary, Joseph Barrash, Mark Granner, Kenneth Manzel, Audrey Greider, Robert Jones
OBJECTIVE: The intracarotid sodium amytal procedure (the "Wada test") has for many years been the gold standard for language and memory lateralization and remains an important part of presurgical analysis for patients with medically intractable seizures. Due to shortages in the key sedative (amobarbital), neuropsychologists have turned to alternatives such as propofol. Our aim was to investigate the safety and efficacy of propofol relative to amobarbital in the Wada test. METHODS: We performed a retrospective review of the 97 Wada procedures performed at University of Iowa Hospitals and Clinics from 2007 through mid-2015...
November 20, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29168570/specific-immunotherapy-in-lar-a-randomized-double-blind-placebo-controlled-trial-with-phleum-pratense-subcutaneous-allergen-immunotherapy
#5
Carmen Rondón, Natalia Blanca-López, Paloma Campo, Cristobalina Mayorga, Raquel Jurado-Escobar, Maria J Torres, Gabriela Canto, Miguel Blanca
BACKGROUND: Allergen immunotherapy has been shown to be an effective treatment for local allergic rhinitis (LAR) to house dust mites. Studies with pollen allergen immunotherapy are limited to observational studies. The aim of this study was to evaluate the clinical efficacy and safety of Phleum pratense subcutaneous immunotherapy (Phl-SCIT) in LAR. METHODS: In a randomized double-blind placebo-controlled study, 56 patients with moderate-severe LAR to grass pollen received Phl-SCIT with a depigmented-polymerized pollen vaccine or placebo for the first year, and Phl-SCIT the second one...
November 23, 2017: Allergy
https://www.readbyqxmd.com/read/29168567/preparation-and-mechanism-analysis-of-an-environment-friendly-maize-seed-coating-agent
#6
Defang Zeng, Zhao Fan, Xu Tian, Wenjin Wang, Mingchun Zhou, Haochuan Li
BACKGROUND: Traditional seed coating agents often contain toxic ingredients, which contaminate environment and threaten human health. This paper expounds a method of preparing a novel environment-friendly seed coating agent for maize and researches its mechanism of action. The natural polysaccharide polymer, which is the main active ingredient of this environment-friendly seed coating agent, has the characteristics of innocuity and harmlessness, and it can replace the toxic ingredients used in the traditional seed coating agents...
November 23, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29168264/beneficial-effects-of-an-investigational-wristband-containing-synsepalum-dulcificum-miracle-fruit-seed-oil-on-the-performance-of-hand-and-finger-motor-skills-in-healthy-subjects-a-randomized-controlled-preliminary-study
#7
Steven Gorin, Charles Wakeford, Guodong Zhang, Elvira Sukamtoh, Charles Joseph Matteliano, Alfred Earl Finch
Miracle fruit (Synsepalum dulcificum) seed oil (MFSO) contains phytochemicals and nutrients reported to affect musculoskeletal performance. The purpose of this study was to assess the safety and efficacy of a compression wristband containing MFSO on its ability to measurably improve the hand and finger motor skills of participants. Healthy right-handed participants (n = 38) were randomized in this double-blind, placebo-controlled study of MFSO and vehicle wristbands. Subjects wore the wristband on their left hand 4-6 weeks and then only on their right hand 2-4 weeks; the contralateral untreated hand served as an additional control...
November 23, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29168225/gaba-modulating-phytomedicines-for-anxiety-a-systematic-review-of-preclinical-and-clinical-evidence
#8
REVIEW
Karen Savage, Joseph Firth, Con Stough, Jerome Sarris
Anxiety disorders are chronic and functionally disabling conditions with high psychological stress, characterised by cognitive symptoms of excessive worry and focus difficulties and physiological symptoms such as muscle tension and insomnia. Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter within the central nervous system and is a key target of pharmacotherapies in the treatment of anxiety. Although current pharmaceutical treatments are often efficacious, they may cause undesirable side effects including cognitive decrements and withdrawal symptoms...
November 23, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29168161/a-multilevel-approach-to-breastfeeding-promotion-using-healthy-start-to-deliver-individual-support-and-drive-collective-impact
#9
Chelsey Leruth, Jacqueline Goodman, Brian Bragg, Dara Gray
Purpose Breastfeeding has been linked to a host of positive health effects for women and children. However, disparities in breastfeeding initiation and duration prevent many low-income and African-American women from realizing these benefits. Existing breastfeeding promotion efforts often do not reach women who need support the most. In response, the Westside Healthy Start program (WHS), located in Chicago, Illinois, developed an ongoing multilevel approach to breastfeeding promotion. Description Key elements of our WHS breastfeeding model include individual education and counseling from pregnancy to 6 months postpartum and partnership with a local safety-net hospital to implement the Baby-Friendly Hospital Initiative and provide lactation support to delivering patients...
November 22, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29168127/bioavailability-of-orally-administered-des-aspartate-angiotensin-i-in-human-subjects
#10
Kok-Onn Lee, Edmund Feng Tian, Martin Hui Cai, Hong Wang, Yiong-Huak Chan, Meng-Kwoon Sim
In an earlier single-dose escalation study to evaluate the safety and pharmacokinetics of orally administered des-aspartate-angiotensin I (DAA-I) in healthy subjects, the plasma level of DAA-I could not be determined because DAA-I is rapidly degraded in the circulation. The present study investigated the oral bioavailability of DAA-I by measuring the prostaglandin E2 metabolite (PGEM) in the plasma samples of the same trial. PGEM is a stable derivative of PGE2, which has been shown to be a biomarker of DAA-I...
November 22, 2017: Drugs in R&D
https://www.readbyqxmd.com/read/29168037/efficacy-and-safety-of-reinfusion-of-concentrated-ascitic-fluid-for-malignant-ascites-a-concept-proof-study
#11
Rumi Hanada, Naosuke Yokomichi, Chihiro Kato, Kazumi Miki, Sachiko Oyama, Tatsuya Morita, Ryoko Kawahara
PURPOSE: Malignant ascites is one of the symptoms causing discomfort in advanced cancer patients. Cell-free and concentrated ascites reinfusion therapy (CART) is one treatment modality, but controlled trials are limited. The primary aim of this study was to explore the efficacy and safety of CART, as well as their predictors, to obtain data for planning a further controlled trial. METHODS: This was a single center retrospective cohort study in patients with refractory malignant ascites...
November 22, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29167967/safety-and-feasibility-of-chemoembolization-with-doxorubicin-loaded-small-calibrated-microspheres-in-patients-with-hepatocellular-carcinoma-results-of-the-miracle-i-prospective-multicenter-study
#12
Götz Richter, Boris Radeleff, Christian Stroszczynski, Philippe Pereira, Thomas Helmberger, Mark Barakat, Peter Huppert
PURPOSE: The MIRACLE I pilot study was designed as a preliminary investigation of safety and efficacy of Embozene TANDEM microspheres loaded with doxorubicin for treatment of locally untreatable (i.e., unresectable and not suitable for local thermal ablation) hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Patients with locally untreatable HCC (mono- or bilobar disease, ECOG performance status 0-2, Child-Pugh score < 11) were eligible for this single-arm multicenter study...
November 22, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29167868/efficacy-and-safety-of-titanium-miniplates-for-patients-undergoing-septorhinoplasty
#13
Paul A Mittermiller, Clifford C Sheckter, Sam P Most
No abstract text is available yet for this article.
November 22, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/29167718/preparation-prerequisites-for-effective-irrigation-of-apical-root-canal-a-critical-review
#14
REVIEW
Dimitrios Tziafas, Dana Alraeesi, Reem Al Hormoodi, Maamoun Ataya, Hessa Fezai, Nausheen Aga
Background: It is well recognized that disinfection of the complex root canal system at the apical root canal remains the most critical therapeutic measure to treat apical periodontitis. Material and Methods: Observational and experimental data in relation to the anatomy of the apical root canal in different tooth types and the cross sectional diameters of the apical part of the most commonly used hand and rotary files are critically reviewed. Results: The present data analysis confirm that the challenging issue of antibacterial efficacy of modern preparation protocols in non-surgical endodontics requires more attention to apical root canal irrigation as a balance between safety and effectiveness...
October 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29167691/long-term-efficacy-and-safety-of-fourth-line-multikinase-inhibitor-treatment-with-lenvatinib-in-a-young-papillary-thyroid-carcinoma-patient
#15
S Morelli, E Puxeddu
Lenvatinib, a multikinase inhibitor, is approved for the treatment of patients with radioiodine-refractory metastatic thyroid cancer on the basis of a Phase III, prospective, double-blind, randomized, placebo-controlled trial that showed longer progression-free survival in the drug-treated arm. Here, we report the case of a young papillary thyroid cancer patient, pretreated with three other kinase inhibitors, who achieved a long-term clinical benefit from lenvatinib in the fourth-line setting.
2017: Drugs in Context
https://www.readbyqxmd.com/read/29167555/efficacy-and-safety-of-low-dose-alteplase-for-intravenous-thrombolysis-in-asian-stroke-patients-a-meta-analysis
#16
Ge Tan, Haijiao Wang, Sihan Chen, Deng Chen, Lina Zhu, Da Xu, Yu Zhang, Ling Liu
Whether low dose alteplase is comparable to standard dose in efficacy and safety for intravenous thrombolysis (IVT) in Asian stroke patients remains unverified. PubMed, EMBASE, and Cochrane Library Database from the beginning to June 30, 2017 were searched. IVT efficacy was measured by favorable outcome (modified Rankin Scale scores of 0-1) at 3 months, and safety measured by mortality within 3 months and symptomatic intracerebral hemorrhage (SICH). Pooled estimates were conducted using fixed- or random-effects model depending on heterogeneity...
November 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29167006/-efficacy-and-survival-analysis-of-apatinib-in-patients-with-advanced-nonsquamous-non-small-cell-lung-cancer-after-failure-of-first-line-treatment
#17
Xuemin Wang, Weihong Zhang, Weijiao Du, Xinwei Zhang, Xiubao Ren, Shui Cao
BACKGROUND: The efficacy of second or third-line chemotherapy in advanced non-small cell lung cancer (NSCLC) patients is low. The use of targeted drugs brings survival benefit for some patients. Apatinib, as a novel small molecule antiangiogenic drug, has demonstrated satisfactory anticancer activity across a broad range of malignancies. The aim of this study is to evaluate the efficacy and safety of apatinib in patients with advanced NSCLC after first-line treatment failure. METHODS: A retrospective study of 128 patients was conducted to evaluate the safety, short-term efficacy and survival status with different regimens...
November 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/29167002/-efficacy-and-toxicity-of-metronomic-oral-vinorelbinen-in-advanced-non-small-cell-lung-cancer-after-failure-to-multiple-lines-treatments
#18
Shuyang Yao, Yanfei Gu, Yi Zhang
BACKGROUND: The development of new treatments beyond first-line in metastatic non-small cell lung cancer (NSCLC) contributed to the increase in overall survival. Metronomic chemotherapy involves several mechanisms of anti-tumor with less toxicity. Oral vinorelbine has paved the way for innovative treatment strategies through metronomic regimens. Therefore, this study assessed the efficacy and safety of metronomic oral vinorelbinen in advanced NSCLC after failure to multiple-lines treatments...
November 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/29166924/experience-with-etanercept-tocilizumab-and-interleukin-1-inhibitors-in-systemic-onset-juvenile-idiopathic-arthritis-patients-from-the-biker-registry
#19
Gerd Horneff, Anna Carina Schulz, Jens Klotsche, Anton Hospach, Kirsten Minden, Ivan Foeldvari, Ralf Trauzeddel, Gerd Ganser, Frank Weller-Heinemann, Johannes Perter Haas
BACKGROUND: Treatment of systemic onset juvenile idiopathic arthritis JIA (sJIA), although dramatically improved, remains a challenge. Experience from clinical practice will be presented using data from the German Biologics register (BiKeR) for evaluation of efficacy and safety of treatment with etanercept (ETA), tocilizumab (TOC) and the interleukin-1 inhibitors anakinra and canakinumab (IL-1i) in sJIA. METHODS: Patients with sJIA documented in the BIKeR register, who were exposed to ETA, TOC or IL-1i were identified...
November 22, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29166874/efficacy-and-safety-of-pertussis-vaccination-for-pregnant-women-a-systematic-review-of-randomised-controlled-trials-and-observational-studies
#20
Marie Furuta, Jacqueline Sin, Edmond S W Ng, Kay Wang
BACKGROUND: Worldwide, pertussis remains a major health problem among children. During the recent outbreaks of pertussis, maternal antenatal immunisation was introduced in several industrial countries. This systematic review aimed to synthesize evidence for the efficacy and safety of the pertussis vaccination that was given to pregnant women to protect infants from pertussis infection. METHODS: We searched literature in the Cochrane Central Register of Controlled Trials, Medline, Embase, and OpenGrey between inception of the various databases and 16 May 2016...
November 22, 2017: BMC Pregnancy and Childbirth
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