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https://www.readbyqxmd.com/read/28899805/performance-of-genotype-%C3%A2-mtbdrplus-assay-in-the-diagnosis-of-drug-resistant-tuberculosis-in-tangier-morocco
#1
Hind Karimi, Latifa En-Nanai, Amal Oudghiri, Imane Chaoui, Amin Laglaoui, Jamal Eddine Bourkadi, Mohammed El Mzibri, Mohammed Abid
OBJECTIVES: In Morocco, tuberculosis (TB) is a major public health problem with high morbidity and mortality. The main problem faced by the National TB program is the high rate of drug resistant (DR), particularly multi-drug resistant (MDR) strains. Diagnosis of DR-TB is mainly performed by conventional techniques which are time consuming with limited efficacy. In 2014, GenoType(®) MTBDRplus assay was introduced in Morocco for drug resistance testing. In this regard, the present study was planned to assess the diagnostic accuracy of GenoType(®) MTBDRplus assay...
September 9, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28889065/profiling-dendritic-cell-subsets-in-the-patients-with-active-pulmonary-tuberculosis
#2
Yuan-Bin Lu, De-Qian Xiao, Kui-Di Liang, Jun-Ai Zhang, Wan-Dang Wang, Shi-Yan Yu, Bi-Ying Zheng, Yu-Chi Gao, You-Chao Dai, Yan Jia, Chen Chen, Ze-Gang Zhuang, Xin Wang, Xiao-Xia Fu, Yong Zhou, Jixin Zhong, Zheng W Chen, Jun-Fa Xu
Dendritic cell (DC) plays an important role in the immune response against pulmonary tuberculosis. However, the phenotypic profile of DC subsets in peripheral blood in individuals with active pulmonary tuberculosis (APT) is still inconclusive. Here, we demonstrated that the absolute numbers of total DC (tDC), myeloid DC (mDC) and plasmacytoid DC (pDC) in individuals with APT were decreased compared to healthy controls (HCs). The decreased number of DCs, especially of pDC, seems to be a useful diagnostic marker of APT...
September 7, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28880875/scaling-up-the-xpert-mtb-rif-assay-for-the-detection-of-tuberculosis-and-rifampicin-resistance-in-india-an-economic-analysis
#3
Sunil Khaparde, Neeraj Raizada, Sreenivas Achuthan Nair, Claudia Denkinger, Kuldeep Singh Sachdeva, Chinnambedu Nainarappan Paramasivan, Virender Singh Salhotra, Anna Vassall, Anja Van't Hoog
BACKGROUND: India is considering the scale-up of the Xpert MTB/RIF assay for detection of tuberculosis (TB) and rifampicin resistance. We conducted an economic analysis to estimate the costs of different strategies of Xpert implementation in India. METHODS: Using a decision analytical model, we compared four diagnostic strategies for TB patients: (i) sputum smear microscopy (SSM) only; (ii) Xpert as a replacement for the rapid diagnostic test currently used for SSM-positive patients at risk of drug resistance (i...
2017: PloS One
https://www.readbyqxmd.com/read/28869693/diabetes-prevalence-and-its-impact-on-health-related-quality-of-life-in-tuberculosis-patients
#4
Ali Nasir Siddiqui, Khalid Umer Khayyam, Nahida Siddiqui, Rohit Sarin, Manju Sharma
OBJECTIVE: To determine the prevalence of diabetes mellitus (DM), assess its influence on health-related quality of life (HRQoL) among TB patients. METHODS: In this prospective study, eligible patients at three primary health care centers in urban slum region of South Delhi, India, underwent blood glucose screening at treatment initiation. HRQoL scores were determined by conducting face-to-face interviews using Dhingra and Rajpal (DR-12) scale at pretreatment, end of intensive phase and end of the treatment...
September 4, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28861650/optimal-timing-of-drug-sensitivity-testing-for-patients-on-first-line-tuberculosis-treatment
#5
Sze-Chuan Suen, Margaret L Brandeau, Jeremy D Goldhaber-Fiebert
Effective treatment for tuberculosis (TB) patients on first-line treatment involves triaging those with drug-resistant (DR) TB to appropriate treatment alternatives. Patients likely to have DR TB are identified using results from repeated inexpensive sputum-smear (SS) tests and expensive but definitive drug sensitivity tests (DST). Early DST may lead to high costs and unnecessary testing; late DST may lead to poor health outcomes and disease transmission. We use a partially observable Markov decision process (POMDP) framework to determine optimal DST timing...
August 31, 2017: Health Care Management Science
https://www.readbyqxmd.com/read/28810911/outcomes-from-patients-with-presumed-drug-resistant-tuberculosis-in-five-reference-centers-in-brazil
#6
D M P Ramalho, P F C Miranda, M K Andrade, T Brígido, M P Dalcolmo, E Mesquita, C F Dias, A N Gambirasio, J Ueleres Braga, A Detjen, P P J Phillips, I Langley, P I Fujiwara, S B Squire, M M Oliveira, A L Kritski
BACKGROUND: The implementation of rapid drug susceptibility testing (DST) is a current global priority for TB control. However, data are scarce on patient-relevant outcomes for presumptive diagnosis of drug-resistant tuberculosis (pDR-TB) evaluated under field conditions in high burden countries. METHODS: Observational study of pDR-TB patients referred by primary and secondary health units. TB reference centers addressing DR-TB in five cities in Brazil. Patients age 18 years and older were eligible if pDR-TB, culture positive results for Mycobacterium tuberculosis and, if no prior DST results from another laboratory were used by a physician to start anti-TB treatment...
August 15, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28802400/mycobacterium-tuberculosis-myma-is-a-tlr2-agonist-that-activate-macrophages-and-a-th1-response
#7
Iti Saraav, Swati Singh, Kirti Pandey, Monika Sharma, Sadhna Sharma
Cell wall of Mycobacterium tuberculosis (M.tb) is a major source of immunogenic proteins that can be tested as vaccine candidates. MymA (Rv3083), a 55 kDa M.tb flavin containing monooxygenase, is involved in modification of mycolic acids during acidic shock following M.tb internalization in macrophage. In this study, we have investigated the role of this cell wall associated protein in activation of macrophages by toll like receptor (TLRs) engagement and subsequent signaling. Our results showed that MymA stimulation of THP1 cells and human monocyte derived macrophages (MDM) lead to upregulation of TLR2 and co-stimulatory molecules CD40, CD80, CD86 and HLA-DR...
September 2017: Tuberculosis
https://www.readbyqxmd.com/read/28794886/evaluation-of-genexpert-mtb-rif-for-determination-of-rifampicin-resistance-among-new-tuberculosis-cases-in-west-and-northwest-iran
#8
S Atashi, B Izadi, S Jalilian, S H Madani, A Farahani, P Mohajeri
Despite a Mycobacterium tuberculosis control programme and anti-tuberculosis drugs, drug-resistant tuberculosis (DR-TB) is one of the most serious public health issues worldwide. Rapid laboratory diagnosis of M. tuberculosis is needed for the diagnosis of multidrug-resistant (MDR) TB and to find the optimal treatment protocol. The purpose of this study was to detect resistance to rifampicin in new cases of TB using the GeneXpert MTB/RIF (M. tuberculosis/rifampicin) assay and the standard proportional method in west and northwest Iran...
September 2017: New Microbes and New Infections
https://www.readbyqxmd.com/read/28746530/hearing-thresholds-in-patients-with-drug-resistant-tuberculosis-baseline-audiogram-configurations-and-associations
#9
Olusola Ayodele Sogebi, Muse Olatunbosun Fadeyi, Bolanle Olufunlola Adefuye, Festus Olukayode Soyinka
Objective: To use baseline audiogram parameters in order to ascertain whether drug-resistant tuberculosis (DR-TB) has effects on hearing, as well as to describe the configurations of the audiograms and to determine whether there are parameters that can be associated with those configurations. Methods: This was a prospective study involving patients diagnosed with DR-TB at a tuberculosis treatment center in the state of Ogun, in Nigeria. The patients included in the study were submitted to pure tone audiometry at baseline (within two weeks after treatment initiation)...
May 2017: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/28746263/treatment-outcomes-of-children-with-hiv-infection-and-drug-resistant-tb-in-three-provinces-in-south-africa-2005-2008
#10
Eric W Hall, Sapna B Morris, Brittany K Moore, Linda Erasmus, Ronel Odendaal, Heather Menzies, Martie van der Walt, Sarah E Smith
OBJECTIVE: To describe outcomes of HIV-infected pediatric patients with drug-resistant tuberculosis (DR TB). METHODS: Demographic, clinical, and laboratory data from pediatric patient charts treated for DR TB during 2005-2008 were collected retrospectively from five MDR TB hospitals in South Africa. Data were summarized and Pearson's chi-squared test or Fisher's exact test were used to assess differences in variables of interest by HIV status. A time-to-event analysis was conducted using days from start of treatment to death...
July 19, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28709496/drug-resistant-tuberculosis-coexisting-with-invasive-candidiasis-in-an-immunocompetent-30-year-old-woman-a-case-report
#11
Rakhee Khanduri, Sushant Khanduri, Sanjeev Kumar, Ankur Saini, Arti Kotwal
Invasive candidiasis coexisting with drug-resistant Mycobacterium tuberculosis (DR-TB) in the immunocompetent patient is a rare entity. We report a 30-year-old woman, nondiabetic, who presented to us with complaints of acute onset cough, breathlessness, and fever since 20 days. On thorough investigations, she was diagnosed to be suffering from coexisting drug-resistant tuberculosis and invasive candidiasis. Prompt treatment initiated at right time helped us in saving her life. The unique presentation of this case and that too in an immunocompetent female makes it an interesting case...
July 2017: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/28623123/screening-mutations-in-drug-resistant-mycobacterium-tuberculosis-strains-in-yunnan-china
#12
Daoqun Li, Yuzhu Song, Cheng-Lin Zhang, Xiaofei Li, Xueshan Xia, A-Mei Zhang
Drug-resistant tuberculosis (DR-TB), especially multidrug-resistant tuberculosis (MDR-TB), is a serious medical and societal problem in China. The purpose of this study was to evaluate the mutation characteristics of drug-resistant Mycobacterium tuberculosis (M. tuberculosis) isolates in Yunnan, China. Drug susceptibility testing (DST) was performed in 523 clinical M. tuberculosis isolates. Six drug resistance genes (katG, inhA, rpoB, rpsL, embB, and pncA) were selected to screen for mutations. In total, 54 clinical M...
June 13, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28619539/systemic-immunological-changes-in-patients-with-distinct-clinical-outcomes-during-mycobacterium-tuberculosis-infection
#13
Tatiane Figueiredo Morais-Papini, Jordana Grazziela Alves Coelho-Dos-Reis, Ana Paula Barbosa Wendling, Lis Ribeiro do Vale Antonelli, Pryscilla Fanini Wowk, Vânia Luiza Deperon Bonato, Valéria Maria Augusto, Silvana Elói-Santos, Olindo Assis Martins-Filho, Cláudia Martins Carneiro, Andréa Teixeira-Carvalho
BACKGROUND: The lung lesions in an individual infected with tuberculosis (TB) are surprisingly variable and independent of each other. However, there is no circulating biomarker yet able to segregate patients according to the extent of lung lesions. MATERIALS AND METHODS: In this study, the phenotypic and functional profile of leukocytes of patients with active pulmonary tuberculosis (TB) and controls (CO) were fully scrutinized by immunophenotyping assays and in vitro short-term whole blood culture...
May 26, 2017: Immunobiology
https://www.readbyqxmd.com/read/28604316/when-students-become-patients-tb-disease-among-medical-undergraduates-in-cape-town-south-africa
#14
Helene-Mari Van der Westhuizen, Angela Dramowski
BACKGROUND: Medical students acquire latent tuberculosis (TB) infection at a rate of 23 cases/100 person-years. The frequency and impact of occupational TB disease in this population are unknown. METHODS: A self-administered questionnaire was distributed via email and social media to current medical students and recently graduated doctors (2010 - 2015) at two medical schools in Cape Town. Individuals who had developed TB disease as undergraduate students were eligible to participate...
May 24, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28578621/drug-resistant-tuberculosis-in-zhejiang-province-china-an-updated-analysis-of-time-trends-1999-2013
#15
Beibei Wu, Le Zhang, Zhengwei Liu, Haibo He, Aizhen Pan, Fei Wang, Mingwu Zhang, Bin Chen, Zuhong Lu, Songhua Chen, Xiaomeng Wang
BACKGROUND: Multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) hinder the progress of TB control. OBJECTIVE: To track the trend of drug-resistant tuberculosis (DR-TB) prevalence in Zhejiang Province from 1999 to 2013, and identify risk factors of resistance to second-line drugs among MDR-TB patients. DESIGN: Four DR-TB surveys had been done in Zhejiang Province in 1999, 2004, 2008 and 2013 through questionnaires, in which demographic and epidemiological items were included...
2017: Global Health Action
https://www.readbyqxmd.com/read/28562103/the-paradigm-shift-to-end-tuberculosis-are-we-ready-to-assume-the-changes
#16
Ignacio Monedero, Rajita Bhavaraju, Alberto Mendoza-Ticona, Adrián Sánchez-Montalvá
Tuberculosis (TB) is the number one infectious disease killer and exemplifies the most neglected of them. Drug-susceptible TB presents with high mortality especially in atypical forms, disproportionally affecting immunosuppressed and vulnerable populations. The drug-resistant TB (DR-TB) epidemic, a world crisis, is sustained and increased through person-to-person transmission in households and the community. TB diagnostics and treatment in recent years are highly evolving fields. New rapid molecular tests are changing the perspectives in diagnosis and resistance screening...
June 5, 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/28494250/recent-developments-of-coumarin-containing-derivatives-and-their-anti-tubercular-activity
#17
Yuan-Qiang Hu, Zhi Xu, Shu Zhang, Xiang Wu, Jun-Wei Ding, Zao-Sheng Lv, Lian-Shun Feng
Tuberculosis (TB) is a lift-threatening chronic deadliest infectious disease caused predominantly by Mycobacterium tuberculosis (MTB) which affects primarily the lungs (pulmonary TB) apart from other vital organs. The emergence of drug-resistant TB (DR-TB), multidrug-resistant TB (MDR-TB), extensively drug-resistant TB (XDR-TB) and the recently cases of totally drug resistant (TDR) towards currently accessible standard drugs was increased up to alarming level in the recent decades. In pursuit of searching new anti-TB agents, numerous of derivatives have been synthesized and screened for their anti-TB activity...
May 2, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28480653/the-rate-of-drug-resistant-tuberculosis-in-korean-children-and-adolescents-since-2007
#18
Hyun Jung Kim, Hyung Ho Yoon, Byung Wook Eun, Youngmin Ahn, Sungweon Ryoo, Hee Jin Kim
The incidence of drug-resistant tuberculosis (DR-TB) in pediatric populations is a critical indicator of national TB management and treatment strategies. Limited data exist regarding the rate of pediatric DR-TB. In this study, we aimed to analyze the status of DR-TB in Korean children from 2007 to 2013. We analyzed specimens submitted to the Korean Institute of Tuberculosis using Mycobacterium tuberculosis culture and drug susceptibility tests (DSTs) from January 2007 through December 2013. Specimens from patients ≤ 19 years of age were included...
June 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28419314/adverse-drug-reactions-during-drug-resistant-tb-treatment-in-high-hiv-prevalence-settings-a-systematic-review-and-meta-analysis
#19
Kathryn Schnippel, Cynthia Firnhaber, Rebecca Berhanu, Liesl Page-Shipp, Edina Sinanovic
Objectives: To estimate the prevalence of adverse drug reactions or events (ADR) during drug-resistant TB (DR-TB) treatment in the context of settings with high HIV prevalence (at least 20% of patients). Methods: We conducted a systematic review and meta-analysis of articles in PubMed and Scopus. Pooled proportions of patients experiencing adverse events and relative risk with 95% CI were calculated. Results: The search yielded 24 studies, all observational cohorts...
July 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28399971/drug-resistant-tuberculosis-in-patients-with-minimal-symptoms-favourable-outcomes-in-the-absence-of-treatment
#20
M Loveday, A Ramjee, G Osburn, I Master, G Kabera, J C M Brust, N Padayatchi, R Warren, G Theron
SETTING: Referral hospital for drug-resistant tuberculosis (DR-TB) in KwaZulu-Natal Province, South Africa. OBJECTIVE: To review the clinical outcomes of patients (age  14 years) with a laboratory-confirmed diagnosis of DR-TB who had minimal symptoms and/or did not have chest radiographic evidence of active disease at referral. These patients were not started on treatment, but were enrolled in an observation programme with follow-up at 2, 6 and 12 months. RESULTS: Of 3345 referred patients diagnosed with DR-TB, 192 (6%) were enrolled in the observation programme...
May 1, 2017: International Journal of Tuberculosis and Lung Disease
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