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https://www.readbyqxmd.com/read/29779775/accuracy-of-whole-genome-sequencing-versus-phenotypic-mgit-and-commercial-molecular-tests-for-detection-of-drug-resistant-mycobacterium-tuberculosis-isolated-from-patients-in-brazil-and-mozambique
#1
Cinara Silva Feliciano, Evangelina Inacio Namburete, Jéssica Rodrigues Plaça, Kamila Peronni, Anzaan Dippenaar, Robin Mark Warren, Wilson Araújo Silva, Valdes Roberto Bollela
BACKGROUND: The fast and accurate diagnosis of drug-resistant tuberculosis (DR-TB) is critical to reducing the spread of disease. Although commercial genotypic drug-susceptibility tests (DST) are close to the goal, they are still not able to detect all relevant DR-TB related mutations. Whole genome sequencing (WGS) allows better comprehension of DR-TB with a great discriminatory power. We aimed to evaluate WGS in M. tuberculosis isolates compared with phenotypic and genotypic DST. METHODS: This cross-sectional study evaluated 30 isolates from patients with detected DR-TB in Brazil and Mozambique...
May 2018: Tuberculosis
https://www.readbyqxmd.com/read/29768580/factors-associated-with-loss-to-follow-up-and-death-in-cases-of-drug-resistant-tuberculosis-dr-tb-treated-at-a-reference-center-in-rio-de-janeiro-brazil
#2
Paulo Victor de Sousa Viana, Paulo Redner, Jesus Pais Ramos
Drug-resistant tuberculosis (DR-TB) poses a serious threat to tuberculosis (TB) control in Brazil and worldwide. The current study investigated factors associated with loss to follow-up and death in the course of treatment for DR-TB in a tertiary reference center in the city of Rio de Janeiro, Brazil. This was a retrospective cohort study of cases reported to the Information System on Special Treatments for Tuberculosis (SITETB) from January 1, 2012, to December 31, 2013. A total of 257 patients were reported to the SITETB and initiated treatment for DR-TB...
May 10, 2018: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/29750764/linezolid-containing-treatment-regimens-for-tuberculosis-in-children
#3
Luis M Prieto, Begoña Santiago, Teresa Del Rosal, Begoña Carazo, Ana B Jiménez, Beatriz Pérez-Gorricho, Felipe Rubio, Alfredo Tagarro, Daniel Blázquez, David Moreno-Pérez, María J Mellado, Fernando Baquero-Artigao
BACKGROUND: In recent years there is an increasing interest in the use of linezolid for the treatment of tuberculosis (TB). METHODS: Patients under 18 years of age who received linezolid within the Spanish Pediatric TB Network (pTBred) from 2001 to 2016 were retrospectively included. Treatment characteristics, adverse events (AEs) and outcomes were analyzed. RESULTS: Fifteen children were included (53% male) with a median age of 3.6 years (IQR: 1...
May 10, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29683992/the-risk-of-nephrotoxicity-in-patients-with-drug-resistant-tuberculosis-treated-with-kanamycin-capreomycin-with-or-without-concomitant-use-of-tenofovir-containing-antiretroviral-therapy
#4
R Perumal, N Abdelghani, N Naidu, N Yende-Zuma, H Dawood, K Naidoo, N Singh, N Padayatchi
BACKGROUND: The intersection of HIV and drug-resistant TB presents the challenge of managing convergent drug toxicities. METHODS: We conducted a retrospective study of adult drug-resistant TB patients treated with a kanamycin/capreomycin-based(KM) regimen, with or without concomitant ART. We estimated the incidence of nephrotoxicity (defined as an increase in serum creatinine greater than 26.5µmol, or an increase in serum creatinine to 1.5 times the baseline value, or a decline in eGFR to less than 60ml/min/1...
April 20, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29677210/provider-reported-barriers-and-solutions-to-improve-testing-among-tuberculosis-patients-eligible-for-drug-susceptibility-test-a-qualitative-study-from-programmatic-setting-in-india
#5
Hemant Deepak Shewade, Arun M Kokane, Akash Ranjan Singh, Malik Parmar, Manoj Verma, Prabha Desikan, Sheeba Naz Khan, Ajay M V Kumar
BACKGROUND: In a study conducted in Bhopal district (a setting with facility for molecular drug susceptibility testing (DST)) located in central India in 2014-15, we found high levels of pre-diagnosis attrition among patients with presumptive multi drug-resistant tuberculosis (MDR-TB)-meaning TB patients who were eligible for DST, were not being tested. OBJECTIVES: In this study, we explored the health care provider perspectives into barriers and suggested solutions for improving DST...
2018: PloS One
https://www.readbyqxmd.com/read/29642905/high-use-of-private-providers-for-first-healthcare-seeking-by-drug-resistant-tuberculosis-patients-a-cross-sectional-study-in-yangon-myanmar
#6
Sucitro Dwijayana Sidharta, Jason Dean-Chen Yin, Joanne Su-Yin Yoong, Mishal Sameer Khan
BACKGROUND: Drug resistance is a growing challenge to tuberculosis (TB) control worldwide, but particularly salient to countries such as Myanmar, where the health system is fragmented across the public and private sector. A recent systematic review has identified a critical lack of evidence for local policymaking, particularly in relation to drivers of drug-resistance that could be the target of preventative efforts. To address this gap from a health systems perspective, our study investigates the healthcare-seeking behavior and preferences of recently diagnosed patients with drug-resistant tuberculosis (DR-TB), focusing on the use of private versus public healthcare providers...
April 11, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29642874/pilot-evaluation-of-a-second-generation-electronic-pill-box-for-adherence-to-bedaquiline-and-antiretroviral-therapy-in-drug-resistant-tb-hiv-co-infected-patients-in-kwazulu-natal-south-africa
#7
N Bionghi, A Daftary, B Maharaj, Z Msibi, K R Amico, G Friedland, C Orrell, N Padayatchi, M R O'Donnell
BACKGROUND: The introduction of Bedaquiline, the first new antimycobacterial drug in over 40 years, has highlighted the critical importance of medication adherence in drug-resistant tuberculosis (DR-TB) treatment to prevent amplified drug-resistance and derive sustained benefit. Real-time electronic dose monitoring (EDM) accurately measures adherence and allows for titration of adherence support for anti-retroviral therapy (ART). The goal of this study was to evaluate the accuracy and acceptability of a next-generation electronic pillbox (Wisepill RT2000) for Bedaquiline-containing TB regimens...
April 11, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29596221/increasing-prevalence-of-pediatric-drug-resistant-tuberculosis-in-mumbai-india-and-its-outcome
#8
Miti A Shah, Ira Shah
SETTING: B.J.Wadia Hospital,Mumbai OBJECTIVE:: The prevalence and type of DR-TB was evaluated pre and post-2013 and outcome was studied. DESIGN: Descriptive retrospective study. Children were defined as having DR-TB on the basis of GeneXpert or LPA and/or drug susceptibility testing(DST) of MTB grown on culture or from contact's DST. RESULTS & CONCLUSION: The prevalence of DR-TB was 110 out of 1145 cases (9.6%) which showed an increase, compared to 5...
March 24, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29581940/training-social-workers-to-enhance-patient-centered-care-for-drug-resistant-tb-hiv-in-south-africa
#9
J R Zelnick, B Seepamore, A Daftary, K R Amico, X Bhengu, G Friedland, N Padayatchi, K Naidoo, M R O'Donnell
KwaZulu-Natal, South Africa, is the epicenter of an epidemic of drug-resistant tuberculosis (DR-TB) and human immunodeficiency virus (HIV) co-infection, characterized by low rates of medication adherence and retention in care. Social workers may have a unique role to play in improving DR-TB-HIV outcomes. We designed, implemented and evaluated a model-based pilot training course on patient-centered care, treatment literacy in DR-TB and HIV coinfection, patient support group facilitation, and self-care. Ten social workers participated in a 1-day training course...
March 21, 2018: Public Health Action
https://www.readbyqxmd.com/read/29581938/did-diabetes-mellitus-affect-treatment-outcome-in-drug-resistant-tuberculosis-patients-in-pakistan-from-2010-to-2014
#10
A Latif, A Ghafoor, A Wali, R Fatima, Mahboob Ul-Haq, A Yaqoob, Z Abdullah, H Najmi, N M Khan
Settings: All hospitals managing drug-resistant tuberculosis (DR-TB) according to national guidelines in Pakistan. Objectives: To assess the effect of diabetes mellitus (DM) and factors associated with unfavourable outcomes in DR-TB. Methods: A cross-sectional study based on a retrospective record review of patients enrolled on DR-TB treatment from 2010 to 2014 in Pakistan. DR-TB data reported to Pakistan's National TB Control Programme on a monthly basis were used for the study. Result: Among 5811 patients enrolled on second-line drugs, 8...
March 21, 2018: Public Health Action
https://www.readbyqxmd.com/read/29527302/world-tb-day-2018-the-challenge-of-drug-resistant-tuberculosis
#11
EDITORIAL
Ankur Gupta-Wright, Gillian S Tomlinson, Molebogeng X Rangaka, Helen A Fletcher
On 24th March, the world commemorates the day in 1882 when Dr Robert Koch announced his discovery of Mycobacterium tuberculosis (MTB). Over 130 years later, tuberculosis (TB) continues to affect individuals, communities, and entire health systems and economies. Koch unsuccessfully tried to 'cure' TB, and despite major advances in other areas of medicine, control of TB remains elusive- in 2016 TB was the leading infectious cause of death. The STOP TB partnership and World Health Organization (WHO) have announced their theme for World TB Day 2018 "Wanted: Leaders for a TB-Free World...
2018: F1000Research
https://www.readbyqxmd.com/read/29518098/outcomes-of-hiv-infected-versus-hiv-non-infected-patients-treated-for-drug-resistance-tuberculosis-multicenter-cohort-study
#12
Mathieu Bastard, Elisabeth Sanchez-Padilla, Philipp du Cros, Atadjan Karimovich Khamraev, Nargiza Parpieva, Mirzagaleg Tillyashaykov, Armen Hayrapetyan, Kamene Kimenye, Shazina Khurkhumal, Themba Dlamini, Santiago Fadul Perez, Alex Telnov, Cathy Hewison, Francis Varaine, Maryline Bonnet
BACKGROUND: The emergence of resistance to anti-tuberculosis (DR-TB) drugs and the HIV epidemic represent a serious threat for reducing the global burden of TB. Although data on HIV-negative DR-TB treatment outcomes are well published, few data on DR-TB outcomes among HIV co-infected people is available despite the great public health importance. METHODS: We retrospectively reported and compared the DR-TB treatment outcomes of HIV-positive and HIV-negative patients treated with an individualized regimen based on WHO guidelines in seven countries: Abkhazia, Armenia, Colombia, Kenya, Kyrgyzstan, Swaziland and Uzbekistan...
2018: PloS One
https://www.readbyqxmd.com/read/29513874/type-2-diabetes-alters-the-basal-phenotype-of-human-macrophages-and-diminishes-their-capacity-to-respond-internalise-and-control-mycobacterium-tuberculosis
#13
Nallely Lopez-Lopez, Ana Gabriela Ramos Martinez, Mariana Haydee Garcia-Hernandez, Rogelio Hernandez-Pando, Julio Enrique Castañeda-Delgado, Geanncarlo Lugo-Villarino, Céline Cougoule, Olivier Neyrolles, Bruno Rivas-Santiago, Monica Alejandra Valtierra-Alvarado, Marisela Rubio-Caceres, Jose Antonio Enciso-Moreno, Carmen Judith Serrano
BACKGROUND: Type 2 diabetes (T2D) is a risk factor for the development of tuberculosis (TB), although the associated mechanisms are not known. OBJECTIVES: To study the association between T2D and the basal phenotype of macrophages, and their immune response to Mycobacterium tuberculosis (Mtb) infection. METHODS: We evaluated the influence of T2D on the response of monocyte-derived macrophages (MDM) to Mtb in patients with T2D (n = 10) compared to healthy subjects (n = 9), before and after infection with Mtb clinical isolates bearing different degrees of virulence...
February 19, 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29510850/characteristics-of-mycobacterium-tuberculosis-positive-patients-screened-for-drug-resistant-tuberculosis-at-a-tertiary-health-facility-in-lagos-nigeria
#14
Yetunde A Kuyinu, Babatunde A Odugbemi, Shukrat O Salisu-Olatunji, Funmilade O Adepoju, Olumuyiwa O Odusanya
BACKGROUND: Nigeria is one of the ten countries with the highest tuberculosis (TB) burden globally and is experiencing an increasing incidence of drug resistance. This study aimed to determine the prevalence of mycobacterium tuberculosis and rifampicin resistance (DR-TB) among patients screened at the TB clinic of a tertiary institution in Lagos, South-West, Nigeria. METHODS: A review of records of 840 patients with suspected drug-resistant TB was carried out from Gene Xpert test clinic register at a tertiary health facility from November 2013 to April 2015...
February 2018: Journal of the National Medical Association
https://www.readbyqxmd.com/read/29471906/spatial-clustering-of-drug-resistant-tuberculosis-in-hlabisa-subdistrict-kwazulu-natal-2011-2015
#15
C M Smith, R Lessells, A D Grant, K Herbst, F Tanser
SETTING: Incidencerates of tuberculosis (TB) in South Africa are among the highest in the world, and drug resistance is a major concern. Understanding geographic variations in disease may guide targeted interventions. OBJECTIVE: To characterise the spatial distribution of drug-resistant TB (DR-TB) in a rural area of KwaZulu-Natal, South Africa, and to test for clustering. DESIGN: This was a cross-sectional analysis of DR-TB patients managed at a rural district hospital from 2011 to 2015...
March 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29424965/prevalence-and-risk-factors-of-drug-resistant-extrapulmonary-tuberculosis
#16
Viboon Boonsarngsuk, Khattiya Mangkang, Pitak Santanirand
BACKGROUND: Physicians are usually aware of the occurrence of drug-resistant (DR) pulmonary tuberculosis (PTB), but lack concern about DR-extrapulmonary TB (EPTB). Data regarding the prevalence and risk factors of DR-EPTB remain limited. OBJECTIVES: To determine the prevalence and risk factors of DR-EPTB. METHODS: A retrospective study was performed in patients who had culture-proven Mycobacterium tuberculosis (MTB) from various specimens between January 2013 and December 2015...
February 9, 2018: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29396991/alterations-in-natural-killer-and-dendritic-cell-subsets-in-individuals-with-hiv-associated-neurotuberculosis
#17
Deepashri Rao, Manjunatha M Venkataswamy, Ravi Vasanthapuram, Parthasarathy Satishchandra, Anita Desai
One of the commonest HIV-associated opportunistic infections of the central nervous system is neurotuberculosis. Interaction between HIV, Mycobacterium tuberculosis and host immune system in co-infected individuals may result in altered frequencies of immune cells, thereby modulating dissemination and disease progression. We examined the frequencies of natural killer (NK) cell and dendritic cell (DC) subsets in HIV infected individuals with neurotuberculosis (HIVNTB) as compared to individuals with HIV associated systemic TB (HIVSTB), asymptomatic HIV, non-HIV NTB, non-HIV STB, and healthy controls...
May 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29374587/clinical-outcome-of-multidrug-resistant-tuberculosis-patients-receiving-standardized-second-line-treatment-regimen-in-china
#18
Caihong Xu, Yu Pang, Renzhong Li, Yunzhou Ruan, Lixia Wang, Mingting Chen, Hui Zhang
OBJECTIVES: The aim of this study was to retrospectively analyze the clinical outcome and the risk factors associated with poor outcome of MDR-TB patients receiving standardized second-line treatment regimen in China. METHODS: Between January 2008 and December 2010, a total of 12,100 clinical diagnosed TB cases at high risk of drug-resistant TB (DR-TB) were enrolled in this study. Routine follow-up tests were conducted every month during the 6-month intensive phase, and every two months during the 18-month continuation phase...
April 2018: Journal of Infection
https://www.readbyqxmd.com/read/29360989/evolution-of-drug-resistance-in-mycobacterium-tuberculosis-a-review-on-the-molecular-determinants-of-resistance-and-implications-for-personalized-care
#19
Navisha Dookie, Santhuri Rambaran, Nesri Padayatchi, Sharana Mahomed, Kogieleum Naidoo
Drug-resistant TB (DR-TB) remains a significant challenge in TB treatment and control programmes worldwide. Advances in sequencing technology have significantly increased our understanding of the mechanisms of resistance to anti-TB drugs. This review provides an update on advances in our understanding of drug resistance mechanisms to new, existing drugs and repurposed agents. Recent advances in WGS technology hold promise as a tool for rapid diagnosis and clinical management of TB. Although the standard approach to WGS of Mycobacterium tuberculosis is slow due to the requirement for organism culture, recent attempts to sequence directly from clinical specimens have improved the potential to diagnose and detect resistance within days...
January 19, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29260746/-the-spectrum-of-primary-drug-resistance-of-mycobacterium-tuberculosis-in-patients-with-tuberculosis-in-relation-to-human-immunodeficiency-virus-status
#20
V N Zimina, O E Mikova, T A Varetskaya, D A Oborin, S Yu Degtyareva, V I Sergevnin
AIM: To estimate the detection rate and spectrum of primary drug resistance of Mycobacterium tuberculosis (MBT) in patients with tuberculosis (TB) in relation to their human immunodeficiency virus (HIV) status in a region with high HIV infection rates (the Perm Territory) and to compare of drug-resistant MBT (DR-MBT) in patients with HIV/TB co-infection, by using phenotypic and molecular genetic testing (MGT) methods. SUBJECTS AND METHODS: The results of sputum bacteriological examination were analyzed in 178 HIV-infected patients and 354 non-HIV-infected individuals with a TB diagnosis made in the period July 1, 2014 to August 1, 2015...
2017: Terapevticheskiĭ Arkhiv
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