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Hagop S Akiskal
What I uttered in Athens moved with apparent emotion [that seem to have not escaped Jules Angst's concern] was spontaneous, except for what is printed in the program book, which has somehow vanished from my office, unlike him with his larger than life figure whose memory will live for as long as he lives in the minds and hearts of all those who were privileged to be his family, colleagues, patients, friends, and… countless others, plus those whose email addresses I cannot locate right now sitting in the sunshine of La Jolla-far away from my loved ones-and wondering what ethnic, genetic and environmental factors-perhaps even several Greek gods combined-to produce the original mind and heart of our Athenian friend who, nonetheless, lived in Rome-and now resting not in the 'atheist' cemetery [it took me 5 minutes to spell this word]-but in our hearts for as long as they will beat-perhaps eventually in another realm, 'from whose bourn'-according to Hamlet-no one has ever returned-that's the promise of the Eternal City-where Athanasios is lying...
October 21, 2016: Current Neuropharmacology
Frank Qiu, Hagop S Akiskal, John R Kelsoe, Tiffany A Greenwood
BACKGROUND: Temperament and personality traits have been suggested as endophenotypes for bipolar disorder based on several lines of evidence, including heritability. Previous work suggested an anxious-reactive factor identified across temperament and personality inventories that produced significant group discrimination and could potentially be useful in genetic analyses. We have attempted to further characterize this factor structure in a sample of bipolar patients. METHODS: A sample of 1195 subjects with bipolar I disorder was evaluated, all with complete data available...
October 2, 2016: Journal of Affective Disorders
H Kim, W Kim, L Citrome, H S Akiskal, K C Goffin, S Miller, J N Holtzman, F Hooshmand, P W Wang, S J Hill, T A Ketter
OBJECTIVE: The objective of this study was to assess the strengths and limitations of a mixed bipolar depression definition made more inclusive than that of the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-5) by counting not only 'non-overlapping' mood elevation symptoms (NOMES) as in DSM-5, but also 'overlapping' mood elevation symptoms (OMES, psychomotor agitation, distractibility, and irritability). METHODS: Among bipolar disorder (BD) out-patients assessed with the Systematic Treatment Enhancement Program for BD (STEP-BD) Affective Disorders Evaluation, we assessed prevalence, demographics, and clinical correlates of mixed vs...
September 2016: Acta Psychiatrica Scandinavica
W Kim, H Kim, L Citrome, H S Akiskal, K C Goffin, S Miller, J N Holtzman, F Hooshmand, P W Wang, S J Hill, T A Ketter
OBJECTIVE: Assess strengths and limitations of mixed bipolar depression definitions made more inclusive than that of the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-5) by requiring fewer than three 'non-overlapping' mood elevation symptoms (NOMES). METHOD: Among bipolar disorder (BD) out-patients assessed with Systematic Treatment Enhancement Program for BD (STEP-BD) Affective Disorders Evaluation, we assessed prevalence, demographics, and clinical correlates of mixed vs...
September 2016: Acta Psychiatrica Scandinavica
A Borkowska, M Bieliński, W Szczęsny, K Szwed, M Tomaszewska, A Kałwa, N Lesiewska, R Junik, M Gołębiewski, M Sikora, A Tretyn, K Akiskal, H Akiskal
BACKGROUND AND AIM: Many studies show high prevalence of affective disorders in obese patients. Affective temperament is a subclinical manifestation of such conditions. The 5-HTT gene encoding the serotonin transporter may be involved in both mood and eating dysregulation. The aim of this study was to investigate the influence of a polymorphism in the 5-HTT gene on affective temperament types, depressive symptoms and Body Mass Index (BMI) in obese patients. METHODS: This study involved 390 patients (237 females, and 153 males) with obesity...
September 15, 2015: Journal of Affective Disorders
Marcele Regine de Carvalho, Bruna Brandão Velasques, Rafael C Freire, Maurício Cagy, Juliana Bittencourt Marques, Silmar Teixeira, Rafael Thomaz, Bernard P Rangé, Roberto Piedade, Hagop Souren Akiskal, Antonio Egidio Nardi, Pedro Ribeiro
UNLABELLED: Panic disorder patients are hypervigilant to danger cues and highly sensitive to unpredictable aversive events, what leads to anticipatory anxiety, that is one key component of the disorder maintenance. Prefrontal cortex seems to be involved in these processes and beta band activity may be related to the involvement of top-down processing, whose function is supposed to be disrupted in pathological anxiety. The objective of this study was to measure frontal absolute beta-power (ABP) with qEEG in panic disorder and agoraphobia (PDA) patients compared to healthy controls...
September 15, 2015: Journal of Affective Disorders
Elie G Karam, Lynn Itani, John Fayyad, Elie Hantouche, Aimee Karam, Zeina Mneimneh, Hagop Akiskal, Zoltán Rihmer
BACKGROUND: Several studies have shown temperament variants in suicidality. Yet, to our knowledge, the association between temperaments and suicide attempts has not been studied on a nationally representative level nor systematically in subjects with no mental disorders. Also, although hyperthymic temperament is recognized as protective of most mental disorders, its role in the protection from self-harm remains inconclusive. METHODS: The study is based on nationally representative data of all Lebanese adults...
September 15, 2015: Journal of Affective Disorders
Diogo R Lara, Luísa W Bisol, Gustavo L Ottoni, Hudson W de Carvalho, Dipavo Banerjee, Shahrokh Golshan, Kareen Akiskal, Hagop S Akiskal
BACKGROUND: Akiskal proposed the "rule of three" for behavioral indicators with high specificity for bipolarity in patients with major depression episodes. We evaluated these distinctive behaviors in controls and subjects with major depression or bipolar disorder. METHODS: data was collected in the BRAINSTEP project with questions on general behaviors, style and talents. Univariate analysis was first conducted in 36,742 subjects and confirmatory multivariate analysis in further 34,505 subjects (22% with a mood disorder)...
September 1, 2015: Journal of Affective Disorders
Angelo G I Maremmani, Luca Rovai, Fabio Rugani, Silvia Bacciardi, Enrico Massimetti, Denise Gazzarrini, Liliana Dell'Osso, Fengyi Tang, Hagop S Akiskal, Icro Maremmani
BACKGROUND: Recent celebrity deaths have been widely reported in the media and turned the public attention to the coexistence of mood, psychiatric and substance-abuse disorders. These tragic and untimely deaths motivated us to examine the scientific and clinical data, including our own work in this area. The self-medication hypothesis states that individuals with psychiatric illness tend to use heroin to alleviate their symptoms. This study examined the correlations between heroin use, mood and psychiatric disorders, and their chronology in the context of dual diagnosis...
July 1, 2015: Journal of Affective Disorders
Hagop Akiskal, Cornelius Katona
No abstract text is available yet for this article.
May 15, 2015: Journal of Affective Disorders
Mauro Giovanni Carta, Luca Saba, Maria Francesca Moro, Enrico Demelia, Orazio Sorbello, Mirra Pintus, Elisa Pintus, Tatevik Simavorian, Hagop Akiskal, Luigi Demelia
BACKGROUND: The purpose was to determine if brain damage in Wilson's disease (WD) is different in comorbid bipolar spectrum disorders (BDs), comorbid major depressive disorder (MDD) or without any mood disorders. METHODS: An observational study was conducted on consecutive patients from a center for WD care. The study sample was divided by psychiatric assessment into WD without any mood disorders, WD with BDs and WD with MDD negative at Mood Disorder Questionnaire (MDQ)...
March 2015: General Hospital Psychiatry
Angelo Giovanni Icro Maremmani, Silvia Bacciardi, Nicole D Gehring, Luca Cambioli, Christian Schütz, Hagop S Akiskal, Kerry Jang, Michael Krausz
BACKGROUND: Homeless individuals are an extremely vulnerable and underserved population characterized by overlapping problems of mental illness and substance use. Given the fact that mood disorders are frequently associated with substance use disorders, we wanted to further highlight the role of excitement in substance abuse. Patterns of substance abuse among homeless suffering from unipolar and bipolar depression were compared. The "self-medication hypothesis" which would predict no-differences in substance preference by unipolar (UP) and bipolar (BP) depressed homeless was tested...
May 1, 2015: Journal of Affective Disorders
Konstantinos N Fountoulakis, Maria Gazouli, John Kelsoe, Hagop Akiskal
The treatment of bipolar depression is one of the most challenging issues in contemporary psychiatry. Currently only quetiapine, the olanzapine-fluoxetine combination and recently lurasidone are officially FDA-approved against this condition. The neurobiology of bipolar depression and the possible targets of bipolar antidepressant therapy remain elusive. The current study investigated whether the pharmacodynamic properties of lurasidone fit to a previously developed model which was the first to be derived on the basis of the strict combination of clinical and preclinical data with no input from theory or opinion...
March 2015: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
Konstantinos N Fountoulakis, Melina Siamouli, Stefania Moysidou, Eleonora Pantoula, Katerina Moutou, Panagiotis Panagiotidis, Marina Kemeridou, Eirini Mavridou, Efimia Loli, Elena Batsiari, Antonio Preti, Leonardo Tondo, Xenia Gonda, Nisreen Mobayed, Kareen Akiskal, Hagop Akiskal, Paul Costa, Robert McCrae
BACKGROUND: The revised NEO Personality Inventory (NEO-PI-3) includes 240 items corresponding to the Big Five personality traits (Extraversion, Agreeableness, Conscientiousness, Neuroticism, and Openness to Experience) and subordinate dimensions (facets). It is suitable for use with adolescents and adults (12 years or older). The aim of the current study was to validate the Greek translation of the NEO-PI-3 in the general Greek population. MATERIAL AND METHODS: The study sample included 734 subjects from the general Greek population of whom 59...
2014: Annals of General Psychiatry
B Dolenc, M Z Dernovšek, L Sprah, R Tavcar, G Perugi, H S Akiskal
BACKGROUND: So far there is a scarce of studies dealing with the relationship between different aspects of aggressive behaviour and affective temperaments among various mood disorders. The aim of the present study was to explore in a group of patients with affective mood disorders the relationship between affective temperaments and aggression. METHODS: 100 consecutive outpatients in euthymic phase of mood disorders (46 with bipolar disorder-type I, 18 with bipolar disorder-type II and 36 with major depressive disorder) were self-assessed with the Aggression Questionnaire and the short version of Slovenian Temperament Evaluation of Memphis, Pisa, Paris and San Diego - Autoquestionnaire (TEMPS-A)...
March 15, 2015: Journal of Affective Disorders
María Lolich, Gustavo H Vázquez, Stephanie Zapata, Kareen K Akiskal, Hagop S Akiskal
BACKGROUND: Links between affective temperaments and folk culture have been infrequently explored systematically. Creativity and personality and temperament studies, conversely, have reported several associations. Tango is one of the most typical Argentinean folk dance-musical repertoires. The main purpose of this study is to compare affective temperaments between Argentinean professional tango dancers and the general population. METHODS: TEMPS-A was administered to a sample of 63 professional tango dancers and 63 comparison subjects from the general population who did not practice tango...
March 1, 2015: Journal of Affective Disorders
Kaya K Jacobsen, Caroline M Nievergelt, Tetyana Zayats, Tiffany A Greenwood, Verneri Anttila, Hagop S Akiskal, Jan Haavik, Ole Bernt Fasmer, John R Kelsoe, Stefan Johansson, Ketil J Oedegaard
BACKGROUND: Migraine is a common comorbidity among individuals with bipolar disorder, but the underlying mechanisms for this co-occurrence are poorly understood. The aim of this study was to investigate the genetic background of bipolar patients with and without migraine. METHODS: We performed a genome-wide association analysis contrasting 460 bipolar migraneurs with 914 bipolar patients without migraine from the Bipolar Genome Study (BiGS). RESULTS: We identified one genome-wide significant association between migraine in bipolar disorder patients and rs1160720, an intronic single nucleotide polymorphism (SNP) in the NBEA gene (P=2...
February 1, 2015: Journal of Affective Disorders
Ajandek Eory, Sandor Rozsa, Xenia Gonda, Peter Dome, Peter Torzsa, Tatevik Simavorian, Konstantinos N Fountoulakis, Maurizio Pompili, Gianluca Serafini, Knarig K Akiskal, Hagop S Akiskal, Zoltan Rihmer, Laszlo Kalabay
BACKGROUND: Smoking behaviour and its course is influenced by personality factors. Affective temperaments could allow a more specific framework of the role trait affectivity plays in this seriously harmful health-behaviour. The aim of our study was to investigate if such an association exists in an ageing population with a special emphasis on gender differences. METHODS: 459 primary care patients completed the TEMPS-A, Beck Depression Inventory (BDI) and Hamilton Anxiety Rating Scale (HAM-A)...
February 1, 2015: Journal of Affective Disorders
Armando Piccinni, Antonello Veltri, Davide Costanzo, Federica Vanelli, Caterina Franceschini, Ilenia Moroni, Luciano Domenici, Nicola Origlia, Donatella Marazziti, Hagop Souren Akiskal, Liliana Dell'Osso
BACKGROUND: Brain-derived neurotrophic factor (BDNF) is a neurotrophin involved in neurogenesis and neuroplasticity. Decreased blood levels of BDNF have been found during acute manic and depressive states. BDNF has been proposed as a biomarker in illness phases of mood disorders. No information is available regarding BDNF levels during the mixed states of bipolar disorder (BD). The aim of this study was to evaluate BDNF levels during mixed episodes of BD patients and compare them with those of healthy subjects and depressed patients...
January 15, 2015: Journal of Affective Disorders
Chengmei Yuan, Jia Huang, Keming Gao, Zhiguo Wu, Jun Chen, Yong Wang, Wu Hong, Zhenghui Yi, Yingyan Hu, Lan Cao, Zezhi Li, Kareen K Akiskal, Hagop S Akiskal, Biao Wang, Yiru Fang
BACKGROUND: The short version of Temperament Evaluation of the Memphis, Pisa, Paris, and San Diego-Auto-questionnaire (TEMPS-A) is a useful instrument to measure affective temperaments. Aims of the present study are to validate the Chinese Version of the Short TEMPS-A, and to explore whether it could be useful to distinguish patients with mood disorders from healthy controls or differentiate patients with bipolar disorder (BPD) from those with major depressive disorder (MDD) in Chinese population...
January 1, 2015: Journal of Affective Disorders
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