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M G Carta, A Preti, H S Akiskal
Human population is increasing in immense cities with millions of inhabitants, in which life is expected to run 24 hours a day for seven days a week (24/7). Noise and light pollution are the most reported consequences, with a profound impact on sleep patterns and circadian biorhythms. Disruption of sleep and biorhythms has severe consequences on many metabolic pathways. Suppression of melatonin incretion at night and the subsequent effect on DNA methylation may increase the risk of prostate and breast cancer...
2018: Clinical Practice and Epidemiology in Mental Health: CP & EMH
I Koufaki, V Polizoidou, K N Fountoulakis
The present article attempts first to provide a historical overview of the concept of temperament,The present article attempts first to provide a historical overview of the concept of temperament,since its foundation by Polybos (4th century B.C.) and the school of Cos, its predominant role in theshaping of the anthropological and humanitarian sciences, until the modern theoretical formulations,such as those proposed by Robert Cloninger and Hagop Akiskal. Secondly, recent literature ispresented, which suggests a strong link of different temperament structures to mental health andpsychopathology...
April 2017: Psychiatrikē, Psychiatriki
Hagop S Akiskal
No abstract text is available yet for this article.
April 2017: Current Neuropharmacology
Brian T D Tobe, Andrew M Crain, Alicia M Winquist, Barbara Calabrese, Hiroko Makihara, Wen-Ning Zhao, Jasmin Lalonde, Haruko Nakamura, Glenn Konopaske, Michelle Sidor, Cameron D Pernia, Naoya Yamashita, Moyuka Wada, Yuuka Inoue, Fumio Nakamura, Steven D Sheridan, Ryan W Logan, Michael Brandel, Dongmei Wu, Joshua Hunsberger, Laurel Dorsett, Cordulla Duerr, Ranor C B Basa, Michael J McCarthy, Namrata D Udeshi, Philipp Mertins, Steven A Carr, Guy A Rouleau, Lina Mastrangelo, Jianxue Li, Gustavo J Gutierrez, Laurence M Brill, Nikolaos Venizelos, Guang Chen, Jeffrey S Nye, Husseini Manji, Jeffrey H Price, Colleen A McClung, Hagop S Akiskal, Martin Alda, De-Maw M Chuang, Joseph T Coyle, Yang Liu, Yang D Teng, Toshio Ohshima, Katsuhiko Mikoshiba, Richard L Sidman, Shelley Halpain, Stephen J Haggarty, Yoshio Goshima, Evan Y Snyder
The molecular pathogenesis of bipolar disorder (BPD) is poorly understood. Using human-induced pluripotent stem cells (hiPSCs) to unravel such mechanisms in polygenic diseases is generally challenging. However, hiPSCs from BPD patients responsive to lithium offered unique opportunities to discern lithium's target and hence gain molecular insight into BPD. By profiling the proteomics of BDP-hiPSC-derived neurons, we found that lithium alters the phosphorylation state of collapsin response mediator protein-2 (CRMP2)...
May 30, 2017: Proceedings of the National Academy of Sciences of the United States of America
Luca Rovai, Angelo G I Maremmani, Silvia Bacciardi, Denise Gazzarrini, Alessandro Pallucchini, Vincenza Spera, Giulio Perugi, Icro Maremmani
INTRODUCTION: In the last decade, the comprehension of affective temperaments has helped us to outline the boundaries of mood disorders, and to expand our knowledge of nosographic areas other than those of affectivity, even if affectivity is closely related to them. In the field of substance use disorders, the temperamental profile of heroin addicts and alcoholics has been discussed elsewhere, but no comparison has yet been made between these two patient populations. Such a comparison would help to shed light on the pathogenetic mechanisms that link temperament with substance abuse...
August 15, 2017: Journal of Affective Disorders
Antonella Ciaramella
Evaluation of pain perception in chronic pain patients with a concomitant mood-spectrum disorder. DESIGN: The observational retrospective study is based on patient data collected in psychosomatic consultations held at the Gift Institute for Integrative Medicine in Pisa, Italy, from 2002 to 2014. Evoked pain stimulus threshold and tolerance were evaluated using the cold pressor test. Clinical pain intensity and Sensorial, Affective, and Evaluative dimensions were assessed using the Italian Pain Questionnaire, and Anxiety and Depressive symptoms using the Hospital Anxiety Depression Scale...
December 2017: Psychiatric Quarterly
Hagop S Akiskal
What I uttered in Athens moved with apparent emotion [that seem to have not escaped Jules Angst's concern] was spontaneous, except for what is printed in the program book, which has somehow vanished from my office, unlike him with his larger than life figure whose memory will live for as long as he lives in the minds and hearts of all those who were privileged to be his family, colleagues, patients, friends, and… countless others, plus those whose email addresses I cannot locate right now sitting in the sunshine of La Jolla-far away from my loved ones-and wondering what ethnic, genetic and environmental factors-perhaps even several Greek gods combined-to produce the original mind and heart of our Athenian friend who, nonetheless, lived in Rome-and now resting not in the 'atheist' cemetery [it took me 5 minutes to spell this word]-but in our hearts for as long as they will beat-perhaps eventually in another realm, 'from whose bourn'-according to Hamlet-no one has ever returned-that's the promise of the Eternal City-where Athanasios is lying...
October 21, 2016: Current Neuropharmacology
Frank Qiu, Hagop S Akiskal, John R Kelsoe, Tiffany A Greenwood
BACKGROUND: Temperament and personality traits have been suggested as endophenotypes for bipolar disorder based on several lines of evidence, including heritability. Previous work suggested an anxious-reactive factor identified across temperament and personality inventories that produced significant group discrimination and could potentially be useful in genetic analyses. We have attempted to further characterize this factor structure in a sample of bipolar patients. METHODS: A sample of 1195 subjects with bipolar I disorder was evaluated, all with complete data available...
January 1, 2017: Journal of Affective Disorders
H Kim, W Kim, L Citrome, H S Akiskal, K C Goffin, S Miller, J N Holtzman, F Hooshmand, P W Wang, S J Hill, T A Ketter
OBJECTIVE: The objective of this study was to assess the strengths and limitations of a mixed bipolar depression definition made more inclusive than that of the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-5) by counting not only 'non-overlapping' mood elevation symptoms (NOMES) as in DSM-5, but also 'overlapping' mood elevation symptoms (OMES, psychomotor agitation, distractibility, and irritability). METHODS: Among bipolar disorder (BD) out-patients assessed with the Systematic Treatment Enhancement Program for BD (STEP-BD) Affective Disorders Evaluation, we assessed prevalence, demographics, and clinical correlates of mixed vs...
September 2016: Acta Psychiatrica Scandinavica
W Kim, H Kim, L Citrome, H S Akiskal, K C Goffin, S Miller, J N Holtzman, F Hooshmand, P W Wang, S J Hill, T A Ketter
OBJECTIVE: Assess strengths and limitations of mixed bipolar depression definitions made more inclusive than that of the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-5) by requiring fewer than three 'non-overlapping' mood elevation symptoms (NOMES). METHOD: Among bipolar disorder (BD) out-patients assessed with Systematic Treatment Enhancement Program for BD (STEP-BD) Affective Disorders Evaluation, we assessed prevalence, demographics, and clinical correlates of mixed vs...
September 2016: Acta Psychiatrica Scandinavica
A Borkowska, M Bieliński, W Szczęsny, K Szwed, M Tomaszewska, A Kałwa, N Lesiewska, R Junik, M Gołębiewski, M Sikora, A Tretyn, K Akiskal, H Akiskal
BACKGROUND AND AIM: Many studies show high prevalence of affective disorders in obese patients. Affective temperament is a subclinical manifestation of such conditions. The 5-HTT gene encoding the serotonin transporter may be involved in both mood and eating dysregulation. The aim of this study was to investigate the influence of a polymorphism in the 5-HTT gene on affective temperament types, depressive symptoms and Body Mass Index (BMI) in obese patients. METHODS: This study involved 390 patients (237 females, and 153 males) with obesity...
September 15, 2015: Journal of Affective Disorders
Marcele Regine de Carvalho, Bruna Brandão Velasques, Rafael C Freire, Maurício Cagy, Juliana Bittencourt Marques, Silmar Teixeira, Rafael Thomaz, Bernard P Rangé, Roberto Piedade, Hagop Souren Akiskal, Antonio Egidio Nardi, Pedro Ribeiro
UNLABELLED: Panic disorder patients are hypervigilant to danger cues and highly sensitive to unpredictable aversive events, what leads to anticipatory anxiety, that is one key component of the disorder maintenance. Prefrontal cortex seems to be involved in these processes and beta band activity may be related to the involvement of top-down processing, whose function is supposed to be disrupted in pathological anxiety. The objective of this study was to measure frontal absolute beta-power (ABP) with qEEG in panic disorder and agoraphobia (PDA) patients compared to healthy controls...
September 15, 2015: Journal of Affective Disorders
Elie G Karam, Lynn Itani, John Fayyad, Elie Hantouche, Aimee Karam, Zeina Mneimneh, Hagop Akiskal, Zoltán Rihmer
BACKGROUND: Several studies have shown temperament variants in suicidality. Yet, to our knowledge, the association between temperaments and suicide attempts has not been studied on a nationally representative level nor systematically in subjects with no mental disorders. Also, although hyperthymic temperament is recognized as protective of most mental disorders, its role in the protection from self-harm remains inconclusive. METHODS: The study is based on nationally representative data of all Lebanese adults...
September 15, 2015: Journal of Affective Disorders
Diogo R Lara, Luísa W Bisol, Gustavo L Ottoni, Hudson W de Carvalho, Dipavo Banerjee, Shahrokh Golshan, Kareen Akiskal, Hagop S Akiskal
BACKGROUND: Akiskal proposed the "rule of three" for behavioral indicators with high specificity for bipolarity in patients with major depression episodes. We evaluated these distinctive behaviors in controls and subjects with major depression or bipolar disorder. METHODS: data was collected in the BRAINSTEP project with questions on general behaviors, style and talents. Univariate analysis was first conducted in 36,742 subjects and confirmatory multivariate analysis in further 34,505 subjects (22% with a mood disorder)...
September 1, 2015: Journal of Affective Disorders
Angelo G I Maremmani, Luca Rovai, Fabio Rugani, Silvia Bacciardi, Enrico Massimetti, Denise Gazzarrini, Liliana Dell'Osso, Fengyi Tang, Hagop S Akiskal, Icro Maremmani
BACKGROUND: Recent celebrity deaths have been widely reported in the media and turned the public attention to the coexistence of mood, psychiatric and substance-abuse disorders. These tragic and untimely deaths motivated us to examine the scientific and clinical data, including our own work in this area. The self-medication hypothesis states that individuals with psychiatric illness tend to use heroin to alleviate their symptoms. This study examined the correlations between heroin use, mood and psychiatric disorders, and their chronology in the context of dual diagnosis...
July 1, 2015: Journal of Affective Disorders
Hagop Akiskal, Cornelius Katona
No abstract text is available yet for this article.
May 15, 2015: Journal of Affective Disorders
Mauro Giovanni Carta, Luca Saba, Maria Francesca Moro, Enrico Demelia, Orazio Sorbello, Mirra Pintus, Elisa Pintus, Tatevik Simavorian, Hagop Akiskal, Luigi Demelia
BACKGROUND: The purpose was to determine if brain damage in Wilson's disease (WD) is different in comorbid bipolar spectrum disorders (BDs), comorbid major depressive disorder (MDD) or without any mood disorders. METHODS: An observational study was conducted on consecutive patients from a center for WD care. The study sample was divided by psychiatric assessment into WD without any mood disorders, WD with BDs and WD with MDD negative at Mood Disorder Questionnaire (MDQ)...
March 2015: General Hospital Psychiatry
Angelo Giovanni Icro Maremmani, Silvia Bacciardi, Nicole D Gehring, Luca Cambioli, Christian Schütz, Hagop S Akiskal, Kerry Jang, Michael Krausz
BACKGROUND: Homeless individuals are an extremely vulnerable and underserved population characterized by overlapping problems of mental illness and substance use. Given the fact that mood disorders are frequently associated with substance use disorders, we wanted to further highlight the role of excitement in substance abuse. Patterns of substance abuse among homeless suffering from unipolar and bipolar depression were compared. The "self-medication hypothesis" which would predict no-differences in substance preference by unipolar (UP) and bipolar (BP) depressed homeless was tested...
May 1, 2015: Journal of Affective Disorders
Konstantinos N Fountoulakis, Maria Gazouli, John Kelsoe, Hagop Akiskal
The treatment of bipolar depression is one of the most challenging issues in contemporary psychiatry. Currently only quetiapine, the olanzapine-fluoxetine combination and recently lurasidone are officially FDA-approved against this condition. The neurobiology of bipolar depression and the possible targets of bipolar antidepressant therapy remain elusive. The current study investigated whether the pharmacodynamic properties of lurasidone fit to a previously developed model which was the first to be derived on the basis of the strict combination of clinical and preclinical data with no input from theory or opinion...
March 2015: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
Konstantinos N Fountoulakis, Melina Siamouli, Stefania Moysidou, Eleonora Pantoula, Katerina Moutou, Panagiotis Panagiotidis, Marina Kemeridou, Eirini Mavridou, Efimia Loli, Elena Batsiari, Antonio Preti, Leonardo Tondo, Xenia Gonda, Nisreen Mobayed, Kareen Akiskal, Hagop Akiskal, Paul Costa, Robert McCrae
BACKGROUND: The revised NEO Personality Inventory (NEO-PI-3) includes 240 items corresponding to the Big Five personality traits (Extraversion, Agreeableness, Conscientiousness, Neuroticism, and Openness to Experience) and subordinate dimensions (facets). It is suitable for use with adolescents and adults (12 years or older). The aim of the current study was to validate the Greek translation of the NEO-PI-3 in the general Greek population. MATERIAL AND METHODS: The study sample included 734 subjects from the general Greek population of whom 59...
2014: Annals of General Psychiatry
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