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https://www.readbyqxmd.com/read/29166710/-effects-of-hydrogen-on-the-lung-damage-of-mice-at-early-stage-of-severe-burn
#1
C Qin, Y X Bian, T T Feng, J H Zhang, Y H Yu
Objective: To investigate the effects of hydrogen on the lung damage of mice at early stage of severe burn. Methods: One hundred and sixty ICR mice were divided into sham injury, hydrogen, pure burn, and burn+ hydrogen groups according to the random number table, with 40 mice in each group. Mice in pure burn group and burn+ hydrogen group were inflicted with 40% total body surface area full-thickness scald (hereafter referred to as burn) on the back, while mice in sham injury group and hydrogen group were sham injured...
November 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29166686/-bone-cement-adhesion-on-ceramic-surfaces-deactivation-of-surfaces-and-as-a-consequence-inefficient-retention-of-knee-prostheses-because-of-adsorption-of-atmospheric-water
#2
Bernd Marx, Philip Kerschbaum, Stephanie Lindlahr, Rudolf Marx, Uwe Reisgen, Dieter Christian Wirtz
Aim CoCrMo alloys are contraindicated for sufferers from allergy. For these patients, uncemented and cemented prostheses made of non-allergenic titanium alloy are indicated. Knee prostheses machined from that alloy, however, may have poor tribological behaviour, especially in contact to UHMWPE inlays. Therefore, high-strength oxide ceramics may be especially suitable for knee replacement in allergy patients with mobile bearing prostheses. For adhesion to bone cement, the ceramic surface only exhibits mechanical retention spots that are less adequate than those with a textured metal surface...
November 22, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29166625/ambient-surface-mass-spectrometry-ion-mobility-spectrometry-of-intact-proteins
#3
REVIEW
Rian L Griffiths, Klaudia I Kocurek, Helen J Cooper
Ambient surface mass spectrometry encompasses a broad range of sampling and ionization techniques. To date, only a small subset of these, based on liquid microjunction extraction, have proven suitable for intact protein analysis from thin tissue sections. Liquid extraction surface analysis shows particular promise for this application. Recently, a range of ion mobility spectrometry approaches have been coupled with ambient mass spectrometry. Improvements in signal-to-noise ratios, decreased chemical noise and separation of molecular classes have been described for the analysis of various biological substrates...
November 18, 2017: Current Opinion in Chemical Biology
https://www.readbyqxmd.com/read/29166611/ccr5-directs-the-mobilization-of-cd11b-gr1-ly6c-low-polymorphonuclear-myeloid-cells-from-the-bone-marrow-to-the-blood-to-support-tumor-development
#4
Elias Hawila, Hila Razon, Gizi Wildbaum, Carolin Blattner, Yair Sapir, Yuval Shaked, Viktor Umansky, Nathan Karin
Cells of hematopoietic origin can be subdivided into cells of the lymphoid lineage and those of the myeloid lineage, among which are myeloid-derived suppressor cells (MDSCs). The MDSCs can be further divided into CD11b(+)Ly6G(-)Ly6C(hi) monocytic (Mo) MDSCs and CD11b(+)Ly6G(+)Ly6C(low) polymorphonuclear (PMN) MDSCs. Both subtypes support tumor growth and suppress anti-tumor immunity. Their accumulation at the tumor site includes mobilization from the bone marrow to the blood followed by colonization at the tumor site...
November 21, 2017: Cell Reports
https://www.readbyqxmd.com/read/29166604/capture-of-dense-core-vesicles-at-synapses-by-jnk-dependent-phosphorylation-of-synaptotagmin-4
#5
Vinita Bharat, Michael Siebrecht, Katja Burk, Saheeb Ahmed, Carsten Reissner, Mahdokht Kohansal-Nodehi, Vicky Steubler, Markus Zweckstetter, Jonathan T Ting, Camin Dean
Delivery of neurotrophins and neuropeptides via long-range trafficking of dense core vesicles (DCVs) from the cell soma to nerve terminals is essential for synapse modulation and circuit function. But the mechanism by which transiting DCVs are captured at specific sites is unknown. Here, we discovered that Synaptotagmin-4 (Syt4) regulates the capture and spatial distribution of DCVs in hippocampal neurons. We found that DCVs are highly mobile and undergo long-range translocation but switch directions only at the distal ends of axons, revealing a circular trafficking pattern...
November 21, 2017: Cell Reports
https://www.readbyqxmd.com/read/29166600/dopamine-receptor-damb-signals-via-gq-to-mediate-forgetting-in-drosophila
#6
Sophie Himmelreich, Ikuo Masuho, Jacob A Berry, Courtney MacMullen, Nickolas K Skamangas, Kirill A Martemyanov, Ronald L Davis
Prior studies have shown that aversive olfactory memory is acquired by dopamine acting on a specific receptor, dDA1, expressed by mushroom body neurons. Active forgetting is mediated by dopamine acting on another receptor, Damb, expressed by the same neurons. Surprisingly, prior studies have shown that both receptors stimulate cyclic AMP (cAMP) accumulation, presenting an enigma of how mushroom body neurons distinguish between acquisition and forgetting signals. Here, we surveyed the spectrum of G protein coupling of dDA1 and Damb, and we confirmed that both receptors can couple to Gs to stimulate cAMP synthesis...
November 21, 2017: Cell Reports
https://www.readbyqxmd.com/read/29166589/granulocyte-monocyte-progenitors-and-monocyte-dendritic-cell-progenitors-independently-produce-functionally-distinct-monocytes
#7
Alberto Yáñez, Simon G Coetzee, Andre Olsson, David E Muench, Benjamin P Berman, Dennis J Hazelett, Nathan Salomonis, H Leighton Grimes, Helen S Goodridge
Granulocyte-monocyte progenitors (GMPs) and monocyte-dendritic cell progenitors (MDPs) produce monocytes during homeostasis and in response to increased demand during infection. Both progenitor populations are thought to derive from common myeloid progenitors (CMPs), and a hierarchical relationship (CMP-GMP-MDP-monocyte) is presumed to underlie monocyte differentiation. Here, however, we demonstrate that mouse MDPs arose from CMPs independently of GMPs, and that GMPs and MDPs produced monocytes via similar but distinct monocyte-committed progenitors...
November 21, 2017: Immunity
https://www.readbyqxmd.com/read/29166540/statistical-optimization-of-an-rp-hplc-method-for-the-determination-of-selected-flavonoids-in-berry-juices-and-evaluation-of-their-antioxidant-activities
#8
Andrija Ciric, Milena Jelikic-Stankov, Milica Cvijovic, Predrag Djurdjevic
An isocratic RP-HPLC method for the separation and identification of selected flavonoids (quercetin, rutin, luteolin-7-O-glucoside, kaempferol, and kaempferol-3-O-glucoside) in commercial berries juices (blackcurrant, blueberry, red raspberry and cherry) was developed with the aid of central composite design and response surface methodology. The optimal separation conditions were a mobile phase of 85:15 (% v/v) water/acetonitrile, pH of 2.8 (adjusted with formic acid), flow rate 0.5 mL/min and column temperature of 35 °C...
November 22, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29166363/progress-toward-poliomyelitis-eradication-pakistan-january-2016-september-2017
#9
Youness Elhamidi, Abdirahman Mahamud, Muhammad Safdar, Wasan Al Tamimi, Jaume Jorba, Chukwuma Mbaeyi, Christopher H Hsu, Zubair Wadood, Salmaan Sharif, Derek Ehrhardt
In 1988, the World Health Assembly launched the Global Polio Eradication Initiative. Among the three wild poliovirus serotypes, only wild poliovirus (WPV) type 1 (WPV1) has been detected since 2012. Since 2014, Pakistan, Afghanistan, and Nigeria remain the only countries with continuing endemic WPV1 transmission. This report describes activities conducted and progress made toward the eradication of poliovirus in Pakistan during January 2016-July 2017 and provides an update to previous reports (1,2). In 2016, Pakistan reported 20 WPV1 cases, a 63% decrease compared with 54 cases in 2015 (3)...
November 24, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29166306/the-surgical-management-of-nerve-gaps-present-and-future
#10
Samer Bassilios Habre, Grant Bond, Xi Lin Jing, Epameinondas Kostopoulos, Robert D Wallace, Petros Konofaos
Peripheral nerve injuries can result in significant morbidity, including motor and/or sensory loss, which can affect significantly the life of the patient. Nowadays, the gold standard for the treatment of nerve section is end-to-end neurorrhaphy. Unfortunately, in some cases, there is segmental loss of the nerve trunk. Nerve mobilization allows primary repair of the sectioned nerve by end-to-end neurorrhaphy if the gap is less than 1 cm. When the nerve gap exceeds 1 cm, autologous nerve grafting is the gold standard of treatment...
November 21, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29166183/the-development-of-an-interactive-health-education-model-based-on-the-djuwita-application-for-adolescent-girls
#11
Sri Djuwitaningsih, Setyowati
Alarming incidents of maternal deaths in Indonesia are due to three major causes: bleeding, sepsis, and hypertension, in addition to other non-obstetric causes and unsafe abortions. Adolescent girls contributed to maternal mortality based on early marriage, unwanted pregnancy, and childbirth. Prevention efforts have been taken through government programs and non-governmental organizations, but in practice those were considered ineffective. Thus, a preventative effort in the form of health education should be made, preferably embedded in a popular mobile application that most teenagers would be apt to use...
2017: Compr Child Adolesc Nurs
https://www.readbyqxmd.com/read/29166091/string-like-collective-motion-and-diffusion-in-the-interfacial-region-of-ice
#12
Xinyi Wang, Xuhang Tong, Hao Zhang, Jack F Douglas
We investigate collective molecular motion and the self-diffusion coefficient Ds of water molecules in the mobile interfacial layer of the secondary prismatic plane (112¯0) of hexagonal ice by molecular dynamics simulation based on the TIP4P/2005 water potential and a metrology of collective motion drawn from the field of glass-forming liquids. The width ξ of the mobile interfacial layer varies from a monolayer to a few nm as the temperature is increased towards the melting temperature Tm, in accordance with recent simulations and many experimental studies, although different experimental methods have differed in their precise estimates of the thickness of this layer...
November 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29166040/analytic-derivative-couplings-and-first-principles-exciton-phonon-coupling-constants-for-an-ab-initio-frenkel-davydov-exciton-model-theory-implementation-and-application-to-compute-triplet-exciton-mobility-parameters-for-crystalline-tetracene
#13
Adrian F Morrison, John M Herbert
Recently, we introduced an ab initio version of the Frenkel-Davydov exciton model for computing excited-state properties of molecular crystals and aggregates. Within this model, supersystem excited states are approximated as linear combinations of excitations localized on molecular sites, and the electronic Hamiltonian is constructed and diagonalized in a direct-product basis of non-orthogonal configuration state functions computed for isolated fragments. Here, we derive and implement analytic derivative couplings for this model, including nuclear derivatives of the natural transition orbital and symmetric orthogonalization transformations that are part of the approximation...
June 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29166035/direct-visualization-and-control-of-atomic-mobility-at-100-surfaces-of-ceria-in-the-environmental-transmission-electron-microscope
#14
Matthieu Bugnet, Steven H Overbury, Zili Wu, Thierry Epicier
Ceria is one of the world's most prominent material for applications in heterogeneous catalysis, as catalyst support or catalyst itself. Despite an exhaustive literature on the structure of reactive facets of CeO2 in line with its catalytic mechanisms, the temporal evolution of the atomic surface structure exposed to realistic redox conditions remains elusive. Here, we provide a direct visualization of the atomic mobility of cerium atoms on {100} surfaces of CeO2 nanocubes at room temperature in high vacuum, O2 and CO2 atmospheres in an environmental transmission electron microscope...
November 22, 2017: Nano Letters
https://www.readbyqxmd.com/read/29166005/self-assembly-of-tetrameric-and-hexameric-terpyridine-based-macrocycles-using-cd-ii-zn-ii-and-fe-ii
#15
Lei Wang, Zhe Zhang, Xin Jiang, Jennifer A Irvin, Changlin Liu, Ming Wang, Xiaopeng Li
The self-assembly behavior of a tritopic 2,2':6',2″-terpyridine (tpy) ligand with Cd(II), Zn(II), and Fe(II) has been exploited herein to generate a series of tetrameric and hexameric macrocycles. The main advantage of using such transition metals with an octahedral coordination geometry is their distinct coordination abilities (e.g., binding strength and reversibility). With the same ligand, this study reveals that the supramolecular structural variation between tetrameric and hexameric macrocycle architectures can be precisely controlled using different metal ions with the same coordination geometry...
November 22, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29165900/development-of-a-pre-column-derivatization-hplc-method-with-diode-array-detection-for-the-determination-of-amino-sugars-in-peat-and-soil-humic-acids
#16
Erik Beňo, Róbert Góra, Milan Hutta
The work is focused on the development of a high-performance liquid chromatography method with diode-array detection for the separation and quantitation of the three most abundant amino sugars; d-glucosamine, d-galactosamine, and d-mannosamine. The high-performance liquid chromatography separation was carried out by reversed-phase chromatography on Chromolith Performance RP-18e monolithic column after acid hydrolysis (5 M HCl) and pre-column derivatization of samples using diethyl ethoxymethylenemalonate. Gradient elution and a mobile phase composed of ammonium formate buffer solution (10 mmol L(-1) , pH 3...
November 22, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29165808/mdwrky9-overexpression-confers-intensive-dwarfing-in-the-m26-rootstock-of-apple-by-directly-inhibiting-brassinosteroid-synthetase-mddwf4-expression
#17
Xiaodong Zheng, Yu Zhao, Dongqian Shan, Kun Shi, Lin Wang, Qingtian Li, Na Wang, Jingzhe Zhou, Junzhu Yao, Yuan Xue, Shuang Fang, Jinfang Chu, Yan Guo, Jin Kong
Dwarfing rootstocks enable high-density planting and are therefore highly desirable in modern apple (Malus domestica) production. M26 is a semi-dwarfing rootstock that is used worldwide, but identifying intensive dwarfing rootstock is a major goal of apple breeding programs. Herein, we show that MdWRKY9 mediates dwarfing by directly inhibiting the transcription of the brassinosteroid (BR) rate-limiting synthetase MdDWF4 and reducing BR production. We found that the transcriptional factor MdWRKY9 is highly expressed in all tested dwarfing rootstocks...
November 22, 2017: New Phytologist
https://www.readbyqxmd.com/read/29165784/interventions-for-managing-skeletal-muscle-spasticity-following-traumatic-brain-injury
#18
REVIEW
Anneliese Synnot, Marisa Chau, Veronica Pitt, Denise O'Connor, Russell L Gruen, Jason Wasiak, Ornella Clavisi, Loyal Pattuwage, Kate Phillips
BACKGROUND: Skeletal muscle spasticity is a major physical complication resulting from traumatic brain injury (TBI), which can lead to muscle contracture, joint stiffness, reduced range of movement, broken skin and pain. Treatments for spasticity include a range of pharmacological and non-pharmacological interventions, often used in combination. Management of spasticity following TBI varies from other clinical populations because of the added complexity of behavioural and cognitive issues associated with TBI...
November 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29165783/after-action-review-of-the-2009-10-h1n1-influenza-outbreak-response-ohio-s-public-health-system-s-performance
#19
William A Mase, Beth Bickford, Casey L Thomas, Shamika D Jones, Michael Bisesi
OBJECTIVE: In early 2009, H1N1 influenza was identified within the human population. Centers for Disease Control and Prevention (CDC) officials responded with focused assessment, policy development, and assurances. The response was mobilized through efforts including procurement of adequate vaccine supply, local area span of control, materials acquisition, and facilities and resource identification. METHODS: Qualitative evaluation of the assurance functions specific to the system's ability to assure safe and healthy conditions are reported...
September 2017: Journal of Emergency Management: JEM
https://www.readbyqxmd.com/read/29165734/effects-of-age-joint-angle-and-test-modality-on-strength-production-and-functional-outcomes
#20
Brennan J Thompson, Morgan Whitson, Eric J Sobolewski, Matt S Stock
This study investigated the impact of age, knee joint angle, and strength testing modality on lower body maximal and rapid strength production and assessed the transferability of these characteristics to mobility-related function. Twenty young (age=21.9 yrs) and eighteen elderly (71.1 yrs) adults performed single-joint and multiple-joint isometric maximal voluntary contractions at three knee angles. Outcome measures included peak torque (PT), rate of torque development (RTD), jump height, power, 10 and 400 m walk, and timed chair stand...
November 17, 2017: International Journal of Sports Medicine
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