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https://www.readbyqxmd.com/read/28749605/housing-tenure-as-a-focus-for-reducing-inequalities-in-the-home-safety-environment-evidence-from-growing-up-in-new-zealand
#1
Sarah Berry, Polly Atatoa Carr, Bridget Kool, Jatender Mohal, Susan Morton, Cameron Grant
OBJECTIVES: To determine whether specific demographic characteristics are associated with the presence or absence of household safety strategies. METHODS: This study was conducted within Growing Up in New Zealand, a contemporary longitudinal study of New Zealand (NZ) children. Multivariable analyses were used to examine the maternal (self-prioritised ethnicity, education, age, self-reported health) and household (area-level deprivation, tenure, crowding, residential mobility, dwelling type) determinants of household safety strategies being present in the homes of young children...
July 27, 2017: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/28749591/free-smoking-cessation-mobile-apps-available-in-australia-a-quality-review-and-content-analysis
#2
Louise Thornton, Catherine Quinn, Louise Birrell, Ashleigh Guillaumier, Brad Shaw, Erin Forbes, Mark Deady, Frances Kay-Lambkin
OBJECTIVES: This review aimed to identify free, high-quality, smoking cessation mobile applications (apps) that adhere to Australian smoking cessation treatment guidelines. METHODS: A systematic search of smoking cessation apps was conducted using Google. The technical quality of relevant apps was rated using the Mobile Application Rating Scale. The content of apps identified as high quality was assessed for adherence to smoking cessation treatment guidelines. RESULTS: 112 relevant apps were identified...
July 27, 2017: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/28749545/optimization-of-throughput-in-semipreparative-chiral-liquid-chromatography-using-stacked-injection
#3
Mohammadreza Taheri, Mohsen Fotovati, Seyed-Kiumars Hosseini, Alireza Ghassempour
An interesting mode of chromatography for preparation of pure enantiomers from pure samples is the method of stacked injection as a pseudocontinuous procedure. Maximum throughput and minimal production costs can be achieved by the use of total chiral column length in this mode of chromatography. To maximize sample loading, often touching bands of the two enantiomers is automatically achieved. Conventional equations show direct correlation between touching-band loadability and the selectivity factor of two enantiomers...
July 27, 2017: Chirality
https://www.readbyqxmd.com/read/28749489/optimization-of-ultra-performance-liquid-chromatography-uplc-with-fluorescence-detector-fld-method-for-the-quantitative-determination-of-selected-neurotransmitters-in-rat-brain
#4
Joanna Stragierowicz, Adam Daragó, Sławomir Brzeźnicki, Anna Kilanowicz
BACKGROUND: Glutamate (Glu) and γ-aminobutyric acid (GABA) are the main neurotransmitters in the central nervous system for excitatory and inhibitory processes, respectively. Monitoring these neurotransmitters is an essential tool in establishing pathological functions, among others in terms of occupational exposure to toxic substances. MATERIAL AND METHODS: We present modification of the HPLC (high-performance liquid chromatography) to the UPLC (ultra-performance liquid chromatography) method for the simultaneous determination of glutamate and γ-aminobutyric acid in a single injection...
July 26, 2017: Medycyna Pracy
https://www.readbyqxmd.com/read/28749340/super-resolution-imaging-of-synaptic-and-extra-synaptic-ampa-receptors-with-different-sized-fluorescent-probes
#5
Sang Hak Lee, Chaoyi Jin, En Cai, Pinghua Ge, Yuji Ishitsuka, Kai Wen Teng, Andre A de Thomaz, Duncan L Nall, Murat Baday, Okunola Jeyifous, Daniel Demonte, Christopher M Dundas, Sheldon Park, Jary Y Delgado, William N Green, Paul R Selvin
Previous studies tracking AMPA receptor (AMPAR) diffusion at synapses observed a large mobile extrasynaptic AMPAR pool. Using super-resolution microscopy, we examined how fluorophore size and photostability affected AMPAR trafficking outside of, and within, post-synaptic densities (PSDs) from rats. Organic fluorescent dyes (≈4 nm), quantum dots, either small (≈10 nm diameter; sQDs) or big (>20 nm; bQDs), were coupled to AMPARs via different-sized linkers. We find that >90% of AMPARs labeled with fluorescent dyes or sQDs were diffusing in confined nanodomains in PSDs, which were stable for 15 minutes or longer...
July 27, 2017: ELife
https://www.readbyqxmd.com/read/28749322/integration-of-slack-a-cloud-based-team-collaboration-application-into-research-coordination
#6
Miriam Gofine, Sunday Clark
Practitioners of epidemiology require efficient real-time communication and shared access to numerous documents in order to effectively manage a study. Much of this communication involves study logistics and does not require use of Protected Health Information. Slack is a team collaboration app; it archives all direct messages and group conversations, hosts documents internally, and integrates with the Google Docs application. Slack has both desktop and mobile applications, allowing users to communicate in real-time without the need to find email addresses or phone numbers or create contact lists...
June 30, 2017: Journal of Innovation in Health Informatics
https://www.readbyqxmd.com/read/28749320/reliability-of-heart-rate-mobile-apps-in-young-healthy-adults-exploratory-study-and-research-directions
#7
Maria Parpinel, Laura Scherling, Stefano Lazzer, Vincenzo Della Mea
BACKGROUND: Recently, a number of smartphone apps appeared that allow for heart rate measurements basing on the photoplethysmography principle. In fact, almost every smartphone now has a camera with flash that could be used for that. Some studies appeared on the reliability of some of those apps, with heterogeneous results. OBJECTIVES: The present study aims at adding up evidence in particular during physical activity, by comparing 3 apps on two different platforms (IOs and Android), on a broad range of heart rates...
June 30, 2017: Journal of Innovation in Health Informatics
https://www.readbyqxmd.com/read/28749011/simultaneous-quantification-of-volitinib-and-gefitinib-in-rat-plasma-by-hplc-ms-ms-for-application-to-a-pharmacokinetic-study-in-rats
#8
Chi-Kyoung Noh, Jong-Hwa Lee, Min-Soo Kim, Han-Joo Maeng, Suk-Jae Chung
A rapid, simple and accurate procedure was developed and validated for the simultaneous quantification of two anticancer agents, volitinib and gefitinib in rat plasma by high-performance liquid chromatography with tandem mass spectrometry. The samples were separated by gradient elution from a CN column within five minutes, using 0.1% formic acid in acetonitrile and 10 mM ammonium formate solution (pH 3.0) as mobile phase. When plasma samples were deproteinated by adding methanol, the analytes in the extract were detected in the positive ionization mode with the tracer ion mass of 346...
July 27, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28748781/a-versatile-liquid-chromatographic-method-for-the-simultaneous-determination-of-metformin-sitagliptin-simvastatin-and-ezetimibe-in-different-dosage-forms
#9
Asmaa A El-Zaher, Ehab F Elkady, Hanan M Elwy, Mahmoud Abo El Makarim Saleh
A new LC method is introduced with the concept of its versatile application to widely used drugs from different pharmacological classes. Metformin hydrochloride (MTF), sitagliptin phosphate (SIT), simvastatin (SIM) and ezetimibe (EZB) were simultaneously determined with a simple reversed-phase LC method in which a SIT–SIM binary mixture, present in a dosage form brand, was considered central for its development. Chromatographic separation was achieved with a mobile phase of acetonitrile and 0.02 M potassium dihydrogen phosphate (pH 5...
July 27, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28748529/dual-role-of-monocyte-derived-dendritic-cells-in-trypanosoma-cruzi-infection
#10
Carolina V Poncini, Stella M González-Cappa
Pathogens can cause inflammation when inoculated into the skin. The vector-transmitted protozoan parasite Trypanosoma cruzi induces poor cellular-infiltration and disseminates, causing high mortality in the experimental model. Here, we characterized the inflammatory foci at the parasite inoculation site and secondary lymphoid organs using a murine system. While no macrophages and few neutrophils and monocytes (Mo) were recruited into the skin, T. cruzi infection elicited the mobilization of Ly6C(+) Mo to draining lymph nodes and spleen...
July 27, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28748392/mobile-monitoring-of-traumatic-brain-injury-in-older-adults-challenges-and-opportunities
#11
EDITORIAL
Andrei Irimia, Susan Wei, Nanshu Lu, Constance M Moore, David N Kennedy
No abstract text is available yet for this article.
July 26, 2017: Neuroinformatics
https://www.readbyqxmd.com/read/28748261/long-term-functional-outcomes-after-resection-of-tongue-cancer-determining-the-optimal-reconstruction-method
#12
Yong Bae Ji, Yong Hee Cho, Chang Myeon Song, Youn Hwan Kim, Jeong Tae Kim, Hee Chang Ahn, Kyung Tae
The appropriate tongue reconstruction method is critical for better functional outcomes. The aim of this study was to determine the optimal reconstructive method for restoring postoperative function based on the extent of resection. We retrospectively reviewed 43 patients with lateral oral tongue cancer who underwent glossectomy between January 2010 and October 2014. Tongue mobility, articulation, verbal diadochokinesis, speech intelligibility and swallowing outcomes were assessed 2-3 years postoperative and were analyzed according to resected tongue volume and the method of reconstruction...
July 26, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28747987/experimental-determination-of-three-dimensional-cervical-joint-mobility-in-the-avian-neck
#13
Robert E Kambic, Andrew A Biewener, Stephanie E Pierce
BACKGROUND: Birds have highly mobile necks, but neither the details of how they realize complex poses nor the evolution of this complex musculoskeletal system is well-understood. Most previous work on avian neck function has focused on dorsoventral flexion, with few studies quantifying lateroflexion or axial rotation. Such data are critical for understanding joint function, as musculoskeletal movements incorporate motion around multiple degrees of freedom simultaneously. Here we use biplanar X-rays on wild turkeys to quantify three-dimensional cervical joint range of motion in an avian neck to determine patterns of mobility along the cranial-caudal axis...
2017: Frontiers in Zoology
https://www.readbyqxmd.com/read/28747908/unraveling-rubisco-form-i-and-form-ii-regulation-in-an-uncultured-organism-from-a-deep-sea-hydrothermal-vent-via-metagenomic-and-mutagenesis-studies
#14
Stefanie Böhnke, Mirjam Perner
Ribulose-1,5-bisphosphate carboxylase/oxygenase (RubisCO) catalyzes the first major step of carbon fixation in the Calvin-Benson-Bassham (CBB) cycle. This autotrophic CO2 fixation cycle accounts for almost all the assimilated carbon on Earth. Due to the primary role that RubisCO plays in autotrophic carbon fixation, it is important to understand how its gene expression is regulated and the enzyme is activated. Since the majority of all microorganisms are currently not culturable, we used a metagenomic approach to identify genes and enzymes associated with RubisCO expression...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28747763/efficacy-and-safety-of-very-early-mobilization-in-patients-with-acute-stroke-a-systematic-review-and-meta-analysis
#15
Tao Xu, Xinyuan Yu, Shu Ou, Xi Liu, Jinxian Yuan, Yangmei Chen
Whether very early mobilization (VEM) improves outcomes in stroke patients and reduces immobilization-related complications (IRCs) is currently unknown. The objective of this systematic review and meta-analysis was to evaluate the efficacy and safety of VEM in acute stroke patients following admission. Medline, Embase, and Cochrane Central Register of Controlled Trials databases were searched for randomized controlled trials (RCTs) that examined the efficacy or safety of VEM in patients with acute stroke. VEM was defined as out of bed activity commencing within 24 or 48 hours after the onset of stroke...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28747638/puma-gene-delivery-to-synoviocytes-reduces-inflammation-and-degeneration-of-arthritic-joints
#16
Saw-See Hong, Hubert Marotte, Guillaume Courbon, Gary S Firestein, Pierre Boulanger, Pierre Miossec
In rheumatoid arthritis (RA), the proliferation of fibroblast-like synoviocytes (FLS) is the cause of chronic inflammation in joints and of joint damage. Delivery of the pro-apoptotic gene PUMA to FLS via human adenovirus type 5 (HAdV5) vectors has been tested as a therapeutic approach, but efficiency is hampered by low transduction, as FLS do not express HAdV5 receptors on the cell surface. Here we show that efficient transduction of PUMA in FLS can be achieved by conjugating HAdV5 to a baculovirus, which binds to the cell surface via the envelope glycoprotein Gp64...
July 27, 2017: Nature Communications
https://www.readbyqxmd.com/read/28747517/a-soft-robotic-exosuit-improves-walking-in-patients-after-stroke
#17
Louis N Awad, Jaehyun Bae, Kathleen O'Donnell, Stefano M M De Rossi, Kathryn Hendron, Lizeth H Sloot, Pawel Kudzia, Stephen Allen, Kenneth G Holt, Terry D Ellis, Conor J Walsh
Stroke-induced hemiparetic gait is characteristically slow and metabolically expensive. Passive assistive devices such as ankle-foot orthoses are often prescribed to increase function and independence after stroke; however, walking remains highly impaired despite-and perhaps because of-their use. We sought to determine whether a soft wearable robot (exosuit) designed to supplement the paretic limb's residual ability to generate both forward propulsion and ground clearance could facilitate more normal walking after stroke...
July 26, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28747436/the-alzheimer-s-disease-protective-cd33-splice-variant-mediates-adaptive-loss-of-function-via-diversion-to-an-intracellular-pool
#18
Shoib S Siddiqui, Stevan A Springer, Andrea Verhagen, Venkatasubramaniam Sundaramurthy, Frederico Alisson-Silva, Weiping Jiang, Pradipta Ghosh, Ajit Varki
The immunomodulatory receptor Siglec-3/CD33 influences risk for late-onset Alzheimers disease (LOAD), an apparently human-specific post-reproductive disease. CD33 generates two splice variants: a full-length CD33M transcript produced primarily by the LOAD-risk allele and a shorter CD33m isoform lacking the sialic acid-binding domain, produced primarily from the LOAD-protective allele. A SNP that modulates CD33 splicing to favor CD33m is associated with enhanced microglial activity. Individuals expressing more protective isoform accumulate less brain Beta-amyloid and have a lower LOAD risk...
July 26, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28747411/stroke-of-the-inferiomedial-temporal-lobe-causing-word-agnosia
#19
Hardi Hassan, Huq Ehsanula, Mahendra Pattanshetti
A 69-year-old man presented with sudden loss of ability to recognise written words and remember the meaning of words and names. He could not name the town he lived in nor name his children. It was difficult for him to remember the meaning of concrete and abstract nouns. His speech fluency and understanding of casual talks were normal. He remembered that he had a conversation with his family that morning, but not the exact content. He was referred to the transient ischaemic attack clinic by his general practitioner as he scored low on the abbreviated mental test score...
July 26, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28747297/photoaging-mobile-apps-as-a-novel-opportunity-for-melanoma-prevention-pilot-study
#20
Titus Josef Brinker, Dirk Schadendorf, Joachim Klode, Ioana Cosgarea, Alexander Rösch, Philipp Jansen, Ingo Stoffels, Benjamin Izar
BACKGROUND: Around 90% of melanomas are caused by ultraviolet (UV) exposure and are therefore eminently preventable. Unhealthy tanning behavior is mostly initiated in early adolescence, often with the belief that it increases attractiveness; the problems related to skin atrophy and malignant melanoma are too far in the future to fathom. Photoaging desktop programs, in which an image is altered to predict future appearance, have been successful in positively influencing behavior in adiposity or tobacco prevention settings...
July 26, 2017: JMIR MHealth and UHealth
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