keyword
https://read.qxmd.com/read/38537148/conformation-selection-by-atp-competitive-inhibitors-and-allosteric-communication-in-erk2
#1
JOURNAL ARTICLE
Jake W Anderson, David Vaisar, David N Jones, Laurel M Pegram, Guy P Vigers, Huifen Chen, John G Moffat, Natalie G Ahn
Activation of the extracellular signal-regulated kinase-2 (ERK2) by phosphorylation has been shown to involve changes in protein dynamics, as determined by hydrogen-deuterium exchange mass spectrometry (HDX-MS) and NMR relaxation dispersion measurements. These can be described by a global exchange between two conformational states of the active kinase, named 'L' and 'R,' where R is associated with a catalytically productive ATP-binding mode. An ATP-competitive ERK1/2 inhibitor, Vertex-11e, has properties of conformation selection for the R-state, revealing movements of the activation loop that are allosterically coupled to the kinase active site...
March 27, 2024: ELife
https://read.qxmd.com/read/38537082/khmer-translation-and-cultural-adaptation-of-the-locomotor-capabilities-index-5
#2
JOURNAL ARTICLE
Nerrolyn Ramstrand, Alan Maddock, Thearith Heang, Nil Ean, Sisary Kheng
BACKGROUND: Mobility is a major goal of prosthetic and orthotic rehabilitation, and use of outcome measures to evaluate mobility is necessary for good clinical practice. To support the use of outcome measures worldwide, work is needed to translate relevant instruments and adapt them for use in multiple cultures. OBJECTIVES: The objective of this research was to use a standardized method to translate the Locomotor Capabilities Index-5 (LCI-5) into Khmer, the national language in Cambodia, and to evaluate its cultural integrity by assessing it with a group of prosthesis and orthosis users...
March 22, 2024: Prosthetics and Orthotics International
https://read.qxmd.com/read/38537069/controversies-in-terlipressin-and-transplantation-in-the-united-states-how-do-we-meld-the-two
#3
JOURNAL ARTICLE
Eric M Przybyszewski, Robert M Wilechansky, Paige McLean Diaz, Andrew S Allegretti, Lisa B VanWagner, Giuseppe Cullaro, Josh Levitsky, Pere Ginès, Salvatore Piano, Sumeet K Asrani, Kavish R Patidar
Hepatorenal syndrome-acute kidney injury (HRS-AKI) is a severe complication of cirrhosis that carries a poor prognosis. The recent Food and Drug Administration approval of terlipressin has substantial implications for managing HRS-AKI and liver allocation in the United States (US). Terlipressin has been available in Europe for over a decade, and several countries have adapted policy changes such as Model for End-Stage Liver Disease (MELD) score "lock" for HRS-AKI. In this article, we outline the European experience with terlipressin use and explore the question of whether terlipressin treatment for HRS-AKI should qualify for MELD score "lock" in the US in those who respond to therapy...
March 28, 2024: Liver Transplantation
https://read.qxmd.com/read/38536993/factors-associated-with-voice-related-quality-of-life-among-patients-with-temporomandibular-disorders
#4
JOURNAL ARTICLE
Rüdiger Emshoff, Magdalena Astl, Aris Ioannis Giotakis, Linus Christian Hupp, Andreas Kolk
BACKGROUND: Research would be important for obtaining a better understanding of voice complaints among patients with temporomandibular disorders (TMD). OBJECTIVE: The identification of predictors of voice disorders associated with TMD pain was made according to Diagnostic Criteria for TMD (DC/TMD) Axis I. METHODOLOGY: Functional limitations were measured using the Jaw Functional Limitation Scales for mastication (JFLS-M), jaw mobility (JFLS-JM), and verbal and emotional expression (JFLS-VEE)...
2024: Journal of Applied Oral Science: Revista FOB
https://read.qxmd.com/read/38536852/barriers-and-facilitators-to-parents-engagement-with-and-perceived-impact-of-a-childhood-obesity-app-a-mixed-methods-study
#5
JOURNAL ARTICLE
Madison Milne-Ives, Em Rahman, Hannah Bradwell, Rebecca Baines, Timothy Boey, Alison Potter, Wendy Lawrence, Michelle Helena van Velthoven, Edward Meinert
Childhood obesity is a growing global health concern. Although mobile health apps have the potential to deliver behavioural interventions, their impact is commonly limited by a lack of sufficient engagement. The purpose of this study was to explore barriers and facilitators to engagement with a family-focused app and its perceived impact on motivation, self-efficacy, and behaviour. Parents with at least one child under 18 and healthcare professionals working with children were recruited; all participants were allocated to use the NoObesity app over a 6-month period...
March 2024: PLOS Digit Health
https://read.qxmd.com/read/38536848/exploring-the-drivers-of-agricultural-wages-growth-in-china-a-comprehensive-framework-utilizing-input-output-and-structural-decomposition-methods
#6
JOURNAL ARTICLE
Peijiang Zheng, Yang Li, Yingying Qi
This study explores the factors driving agricultural wages growth in China from 1981 to 2020. We propose a comprehensive framework that combines input-output analysis and structural decomposition analysis to investigate the drivers of agricultural wages growth from four perspectives: supply, demand, industrial linkages, and agricultural support policies. The findings indicate that changes in consumer demand, investment demand, and labor mobility play significant roles in driving the growth of agricultural wages in China...
2024: PloS One
https://read.qxmd.com/read/38536807/turkish-cultural-adaptation-validity-and-reliability-of-the-stroke-activity-scale-in-individuals-with-hemiparesis
#7
JOURNAL ARTICLE
Ayşe Göktaş, Volkan Türkmen, Fulya Damla Çolak, Gamze Ekici
AIM: The aim of this study was to make the Turkish cultural adaptation of the the Stroke Activity Scale (SAS). METHOD: This study was designed as a methodological research. The psychometric properties of the SAS scale were evaluated by validity and reliability analyses. RESULTS: The average age of 84 stroke patients (mean ± SD) was 59.52 ± 14.03 years. Kaiser-Meyer-Olkin (0.816) and Bartlett's Test of Sphericity (χ2 = 288...
March 27, 2024: Topics in Stroke Rehabilitation
https://read.qxmd.com/read/38536795/why-do-people-sell-their-kidneys-a-thematic-synthesis-of-qualitative-evidence
#8
JOURNAL ARTICLE
Bijaya Shrestha, Luechai Sringernyuang, Manash Shrestha, Binita Shrestha, Anuska Adhikari, Dev Ram Sunuwar, Shiva Raj Mishra, Bipin Adhikari
Globally, demands for the kidneys have surpassed supply both living and deceased donors. High demands relative to the availability have made the kidney one of the most saleable human organs. The main objective was to explore the drivers of kidney selling. Literature related to kidney selling and its drivers was explored in three databases including MEDLINE (PubMed), Scopus (Elsevier), and JSTOR covering the period from 1987 to 2022. A total of 15 articles were selected, which underwent thematic analysis. Investigators independently assessed the articles for relevance and study quality to synthesize the data...
2024: PLOS Glob Public Health
https://read.qxmd.com/read/38536454/walking-and-talking-the-plank-dual-task-performance-costs-in-a-virtual-balance-threatening-environment
#9
JOURNAL ARTICLE
Tiphanie E Raffegeau, Sarah A Brinkerhoff, Mindie Clark, Ashlee D McBride, A Mark Williams, Peter C Fino, Bradley Fawver
We evaluated the effects of engaging in extemporaneous speech in healthy young adults while they walked in a virtual environment meant to elicit low or high levels of mobility-related anxiety. We expected that mobility-related anxiety imposed by a simulated balance threat (i.e., virtual elevation) would impair walking behavior and lead to greater dual-task costs. Altogether, 15 adults (age = 25.6 ± 4.7 yrs, 7 women) walked at their self-selected speed within a VR environment that simulated a low (ground) and high elevation (15 m) setting while speaking extemporaneously (dual-task) or not speaking (single-task)...
March 27, 2024: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://read.qxmd.com/read/38536423/-optinofa-intelligent-assistance-service-for-structured-assessment-in-the-emergency-department
#10
JOURNAL ARTICLE
Elisabeth Nyoungui, Marina V Karg, Marc Wieckenberg, Katrin Esslinger, Michael Schmucker, Andreas Reiswich, Kai L Antweiler, Tim Friede, Martin Haag, Harald Dormann, Sabine Blaschke
BACKGROUND: Case numbers in central emergency departments (EDs) have risen during the past decade in Germany, leading to recurrent overcrowding, increased risks in emergency care, and elevated costs. Particularly the fraction of outpatient emergency treatments has increased disproportionately. Within the framework of the Optimization of emergency care by structured triage with intelligent assistant service (OPTINOFA, Förderkennzeichen [FKZ] 01NVF17035) project, an intelligent assistance service was developed...
March 27, 2024: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://read.qxmd.com/read/38536236/outpatient-video-visits-during-the-covid-19-pandemic-cross-sectional-survey-study-of-patients-experiences-and-characteristics
#11
JOURNAL ARTICLE
Stefanie C van den Bosch, Demi van Dalen, Marjan Meinders, Harry van Goor, Stefaan Bergé, Martijn Stommel, Sandra van Dulmen
BACKGROUND: During the first lockdown of the COVID-19 pandemic, an exponential increase in video consultations replacing in-person outpatient visits was observed in hospitals. Insight into patients' experiences with this type of consultation is helpful for a broad, sustainable, and patient-centered implementation of video consultation. OBJECTIVE: This study aims to examine patients' experiences with video consultation during the COVID-19 pandemic and identify discriminative patient and consultation characteristics to determine when video consultation is most feasible...
March 27, 2024: Journal of Medical Internet Research
https://read.qxmd.com/read/38536232/adapting-mhealth-interventions-prepmate-and-dot-diary-to-support-prep-retention-in-care-and-adherence-among-english-and-spanish-speaking-men-who-have-sex-with-men-and-transgender-women-in-the-united-states-formative-work-and-pilot-randomized-trial
#12
JOURNAL ARTICLE
Albert Y Liu, Cat-Dancing Alleyne, Susanne Doblecki-Lewis, Kimberly A Koester, Rafael Gonzalez, Janie Vinson, Hyman Scott, Susan Buchbinder, Thiago S Torres
BACKGROUND: A growing number of mobile health (mHealth) technologies are being developed to support HIV preexposure prophylaxis (PrEP) adherence and persistence; however, most tools have focused on men who have sex with men (MSM), and few are available in Spanish. To maximize the potential impact of these tools in reducing gender and racial/ethnic disparities and promoting health equity, mHealth tools tailored to Spanish-speaking people and transgender women are critically needed. OBJECTIVE: The aim of this study is to adapt and tailor 2 mHealth technologies, PrEPmate and DOT Diary, to support daily PrEP adherence and persistence among Spanish-speaking MSM and English- and Spanish-speaking transgender women and to evaluate the feasibility and acceptability of these tools...
March 27, 2024: JMIR Formative Research
https://read.qxmd.com/read/38536231/assessment-of-the-barriers-and-enablers-of-the-use-of-mhealth-systems-in-sub-saharan-africa-according-to-the-perceptions-of-patients-physicians-and-health-care-executives-in-ethiopia-qualitative-study
#13
JOURNAL ARTICLE
Genet Tadese Aboye, Gizeaddis Lamesgin Simegn, Jean-Marie Aerts
BACKGROUND: Digital technologies are increasingly being used to deliver health care services and promote public health. Mobile wireless technologies or mobile health (mHealth) technologies are particularly relevant owing to their ease of use, broad reach, and wide acceptance. Unlike developed countries, Sub-Saharan Africa experiences more challenges and obstacles when it comes to deploying, using, and expanding mHealth systems. In addition to barriers, there are enabling factors that could be exploited for the design, implementation, and scaling up of mHealth systems...
March 27, 2024: Journal of Medical Internet Research
https://read.qxmd.com/read/38536225/effectiveness-of-the-minder-mobile-mental-health-and-substance-use-intervention-for-university-students-randomized-controlled-trial
#14
JOURNAL ARTICLE
Melissa Vereschagin, Angel Y Wang, Chris G Richardson, Hui Xie, Richard J Munthali, Kristen L Hudec, Calista Leung, Katharine D Wojcik, Lonna Munro, Priyanka Halli, Ronald C Kessler, Daniel V Vigo
BACKGROUND: University attendance represents a transition period for students that often coincides with the emergence of mental health and substance use challenges. Digital interventions have been identified as a promising means of supporting students due to their scalability, adaptability, and acceptability. Minder is a mental health and substance use mobile app that was codeveloped with university students. OBJECTIVE: This study aims to examine the effectiveness of the Minder mobile app in improving mental health and substance use outcomes in a general population of university students...
March 27, 2024: Journal of Medical Internet Research
https://read.qxmd.com/read/38536216/virulence-genes-resistome-and-mobilome-of-streptococcus-suis-strains-isolated-in-france
#15
JOURNAL ARTICLE
Manon Dechêne-Tempier, Claire de Boisséson, Pierrick Lucas, Stéphanie Bougeard, Virginie Libante, Corinne Marois-Créhan, Sophie Payot
Streptococcus suis is a leading cause of infection in pigs, causing extensive economic losses. In addition, it can also infect wild fauna, and can be responsible for severe infections in humans. Increasing antimicrobial resistance (AMR) has been described in S. suis worldwide and most of the AMR genes are carried by mobile genetic elements (MGEs). This contributes to their dissemination by horizontal gene transfer. A collection of 102 strains isolated from humans, pigs and wild boars in France was subjected to whole genome sequencing in order to: (i) study their genetic diversity, (ii) evaluate their content in virulence-associated genes, (iii) decipher the mechanisms responsible for their AMR and their association with MGEs, and (iv) study their ability to acquire extracellular DNA by natural transformation...
March 2024: Microbial Genomics
https://read.qxmd.com/read/38536117/concordance-in-spouses-intention-to-move-after-retirement-among-korean-middle-aged-couples
#16
JOURNAL ARTICLE
Eunju Lee, Kyungmin Kim
This study examined the concordance in spouses' intention to move after retirement among midlife couples and its association with couples' marital characteristics (i.e., marital satisfaction and dyadic coping). Using a sample of 1,285 middle-aged couples in Korea (aged 49-64), we conducted logistic/multinomial regression controlling for individual and household characteristics. The majority of couples (83%) were concordant in their moving desires-by either agreeing to move (29%) or to stay (54%), whereas 17% of couples were not in agreement-either only husband (9%) or wife (8%) desires to move...
March 27, 2024: Journal of Applied Gerontology: the Official Journal of the Southern Gerontological Society
https://read.qxmd.com/read/38536049/circ_0104652-promotes-the-proliferation-and-migration-of-ox-ldl-stimulated-vascular-smooth-muscle-cells-via-stabilizing-adamts7-and-hmgb1
#17
JOURNAL ARTICLE
Bo Bian, Heye Chen, Tianming Teng, Jinyong Huang, Xuefang Yu
BACKGROUND: Atherosclerosis (AS) stands as the primary contributor to cardiovascular disease (CVD), a pervasive global health concern. Extensive research has underscored the pivotal role of circular RNAs (circRNAs) in CVD development. However, the specific functions of numerous circRNAs in AS remain poorly understood. METHODS: Quantitative real-time PCR (RT-qPCR) analysis revealed a significant up-regulation of circ_0104652 in oxidized low-density lipoprotein (ox-LDL)-induced vascular smooth muscle cells (VSMCs)...
March 27, 2024: American Journal of Hypertension
https://read.qxmd.com/read/38535963/electrospinning-chitosan-fe-mn-nanofibrous-composite-for-efficient-and-rapid-removal-of-arsenite-from-water
#18
JOURNAL ARTICLE
Lingli Min, Yahui Ma, Bi Zhang, Dulan He, Jinhua Chen, Xuerong Li, Shuhua Wang, Yulang Chi
Efficient removal of extremely mobile and toxic As(III) from water is a challenging but critical task. Herein, we developed a functionalized sorbent of chitosan nanofiber with iron-manganese (Fe-Mn@CS NF) using a one-step hybrid electrospinning approach to remove trace As(III) from water. Batch adsorption studies were performed to determine the adsorption efficiency under a variety of conditions, including contact time, starting concentration of As(III), ionic strength, and the presence of competing anions...
March 21, 2024: Toxics
https://read.qxmd.com/read/38535932/herbicide-leaching-in-soil-with-different-properties-perspectives-from-commercial-formulations-and-analytical-standards
#19
JOURNAL ARTICLE
Rita de Cássia Araújo de Medeiros, Tatiane Severo Silva, Taliane Maria da Silva Teófilo, Francisca Daniele da Silva, Matheus de Freitas Souza, Ana Beatriz Rocha de Jesus Passos, Bruno Caio Chaves Fernandes, Hamurábi Anizio Lins, Paulo Sergio Fernandes das Chagas, Carolina Malala Martins Souza, Ioná Santos Araújo Holanda, Daniel Valadão Silva
The leaching of herbicides into the soil is essential to control germinating seeds and parts of vegetative weeds. However, herbicide transportation to deeper soil layers can result in groundwater contamination and, consequently, environmental issues. In this research, our objective was to investigate differences in herbicide leaching between commercial formulations and analytical standards using three different soils. Leaching experiments were carried out for diuron, hexazinone, and sulfometuron-methyl herbicides isolated and in binary and ternary mixtures...
March 2, 2024: Toxics
https://read.qxmd.com/read/38535924/plasma-concentrations-of-high-mobility-group-box-1-proteins-and-soluble-receptors-for-advanced-glycation-end-products-are-relevant-biomarkers-of-cognitive-impairment-in-alcohol-use-disorder-a-pilot-study
#20
JOURNAL ARTICLE
Fernando Rodríguez de Fonseca, Francisco Medina-Paz, Mira Sapozhnikov, Isaac Hurtado-Guerrero, Leticia Rubio, Stella Martín-de-Las-Heras, Nerea Requena-Ocaña, María Flores-López, María Del Mar Fernández-Arjona, Patricia Rivera, Antonia Serrano, Pedro Serrano, Sara C Zapico, Juan Suárez
Alcohol use disorder (AUD) is a major component in the etiology of cognitive decline and dementia. Underlying mechanisms by which long-term alcohol abuse causes cognitive dysfunction include excessive oxidative stress and inflammation in the brain, activated by increased reactive oxygen/nitrogen species (ROS/RNS), advanced glycation end-products (AGEs) and high-mobility group box 1 protein (HMGB1). In a pilot study, we examine the potential clinical value of circulating biomarkers of oxidative stress including ROS/RNS, HMGB1, the soluble receptor for AGE (sRAGE), the brain biomarker of aging apolipoprotein D (ApoD), and the antioxidant regulator nuclear factor erythroid 2-related factor 2 (NRF2) as predictive indices for cognitive impairment (CI) in abstinent patients with AUD ( n = 25) compared to patients with established Alzheimer's disease (AD, n = 26) and control subjects ( n = 25)...
February 29, 2024: Toxics
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