Patricia Köferl, Margrit Hollborn, Jiri Rehak, Ianors Iandiev, Sladjana Dukic-Stefanovic, Peter Wiedemann, Leon Kohen, Andreas Bringmann, Matus Rehak
BACKGROUND: To investigate the effect of induced arteriolar constriction (AC) on alterations in gene expression of factors implicated in the development of edema in branch retinal vein occlusion (BRVO). METHODS: In Brown-Norway rats, BRVO was induced by laser photocoagulation of the veins in one half of the retina. AC of the afferent arterioles was performed 30 min later. We then determined the expression of Vegfa, Vegfb, Pedf, Kir4.1, Aqp4, Aqp1, Il1ß, and Il6 with real-time polymerase chain reaction (RT-PCR) in the neuroretina and retinal pigment epithelium (RPE) after 1, 3, and 7 days...
February 2014: Graefe's Archive for Clinical and Experimental Ophthalmology