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AQP4 kir4.1 diabetic retinopathy

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https://www.readbyqxmd.com/read/24382652/aav-mediated-gene-delivery-in-dp71-null-mouse-model-with-compromised-barriers
#1
Ophélie Vacca, Marie Darche, David V Schaffer, John G Flannery, José-Alain Sahel, Alvaro Rendon, Deniz Dalkara
Formation and maintenance of the blood-retinal barrier (BRB) is required for proper vision and breaching of this barrier contributes to the pathology in a wide variety of retinal conditions such as retinal detachment and diabetic retinopathy. Dystrophin Dp71 being a key membrane cytoskeletal protein, expressed mainly in Müller cells, its absence has been related to BRB permeability through delocalization and down-regulation of the AQP4 and Kir4.1 channels. Dp71-null mouse is thus an excellent model to approach the study of retinal pathologies showing blood-retinal barrier permeability...
March 2014: Glia
https://www.readbyqxmd.com/read/21672350/expression-of-aquaporin-4-and-kir4-1-in-diabetic-rat-retina-treatment-with-minocycline
#2
Y Zhang, G Xu, Q Ling, C Da
This study examined aquaporin 4 (AQP4) and Kir4.1 (a potassium channel subunit) in normal and diabetic adult Sprague-Dawley rats, and determined the effect of minocycline treatment. Retinal expression of the AQP4 and Kir4.1 genes was examined using double immuno fluorescence, Western blot analysis, and real-time reverse transcription-polymerase chain reaction. Retinal levels of vascular endothelial growth factor (VEGF), ionized calcium-binding adaptor molecule (Iba)-1 and interleukin (IL)-1β were also ascertained...
2011: Journal of International Medical Research
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