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Taiyo Shijo, Yoichi Sakurada, Seigo Yoneyama, Atsushi Sugiyama, Wataru Kikushima, Naohiko Tanabe, Hiroyuki Iijima
PURPOSE: The purpose of our study was to investigate the clinical and genetic characteristics of pseudodrusen subtypes and their incidence in advanced age-related macular degeneration (AMD). METHODS: We studied 84 eyes from 84 patients with pseudodrusen associated with advanced AMD, including typical AMD, polypoidal choroidal vasculopathy (PCV), retinal angiomatous proliferation (RAP), and geographic atrophy (GA). Multiple imaging modalities, including color fundus photography, spectral-domain optical coherence tomography (SD-OCT), near-infrared reflectance, and fundus autofluorescence, were employed to diagnose pseudodrusen and its subtypes...
March 1, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
Malini Bakthavatsalam, Danny Siu-Chun Ng, Frank Hiu-Ping Lai, Fang Yao Tang, Mårten Erik Brelén, Chi Wai Tsang, Timothy Yuk-Yau Lai, Carol Yim-Lui Cheung
PURPOSE: To evaluate quantitatively the choroidal vascularity in polypoidal choroidal vasculopathy (PCV) and neovascular age-related macular degeneration (AMD) patients compared to healthy controls. METHODS: All eyes underwent swept source optical coherence tomography (OCT), and choroidal images were binarized into blood vessels lumen and stroma. The choroidal vascular index (CVI) was defined as the ratio of luminal area (LA) over total choroidal area of the subfoveal region with a width of 1500 μm...
February 1, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
Chui Ming Gemmy Cheung, Yasuo Yanagi, Aditi Mohla, Shu Yen Lee, Ranjana Mathur, Choi Mun Chan, Ian Yeo, Tien Yin Wong
PURPOSE: To determine the correlation and agreement between swept-source optical coherence tomography angiography (SS-OCT-A) with fluorescein angiography (FA), indocyanine green angiography (ICGA) and spectral domain OCT (SD-OCT) in characterizing polypoidal choroidal vasculopathy (PCV) and in differentiating eyes with typical age-related macular degeneration (t-AMD). METHODS: This study included 32 and 54 eyes with t-AMD and PCV, respectively, who underwent SS-OCT-A, SD-OCT, fluorescein angiography, and indocyanine green angiography...
November 8, 2016: Retina
Jae Hui Kim, Young Suk Chang, Jong Woo Kim, Tae Gon Lee, Chul Gu Kim, Dong Won Lee
PURPOSE: To investigate the characteristics of radiating hemorrhage secondary to exudative age-related macular degeneration (AMD) and its clinical significance. METHODS: This retrospective, observational case series included 288 eyes of 288 patients who initially presented with submacular hemorrhage secondary to exudative AMD. First, we estimated the incidence of radiating hemorrhage; we then compared the incidence of polypoidal choroidal vasculopathy (PCV) compared with that of the other subtypes of AMD...
November 2016: Japanese Journal of Ophthalmology
Young Suk Chang, Jae Hui Kim, Jong Woo Kim, Tae Gon Lee, Chul Gu Kim
PURPOSE: To evaluate the efficacy of an optical coherence tomography (OCT)-based diagnosis of polypoidal choroidal vasculopathy (PCV) in Korean patients. METHODS: This retrospective, observational case series included 263 eyes of 263 patients (147 eyes with PCV and 116 eyes with typical exudative, age-related macular degeneration [AMD]) who had been diagnosed with treatment naïve exudative AMD. Eyes with three or more of the following OCT findings were diagnosed with PCV: multiple retinal pigment epithelial detachment (RPED), a sharp RPED peak, an RPED notch, a hyporeflective lumen representing polyps, and hyperreflective intraretinal hard exudates...
June 2016: Korean Journal of Ophthalmology: KJO
Nagahisa Yoshimura
Age-related macular degeneration (AMD) in the Japanese often shows different clinical features from those described in Caucasians. For example, we often observe choroidal neovascularization (CNV) in elderly patients without drusen in the fundus. The high incidence of polypoidal choroidal vasculopathy (PCV) in AMD among Japanese is well-known. The reason why such differences occur in clinical manifestations of AMD has been one of my main interests. In this review article, I will discuss the characteristics of AMD in the Japanese population, as found in our recent study...
March 2016: Nippon Ganka Gakkai Zasshi
Hideki Koizumi, Mariko Kano, Akiko Yamamoto, Masaaki Saito, Ichiro Maruko, Tetsuju Sekiryu, Annabelle A Okada, Tomohiro Iida
PURPOSE: To investigate changes in subfoveal choroidal thickness after intravitreal aflibercept injections (IAIs) for neovascular age-related macular degeneration (AMD) at 12 months. DESIGN: Retrospective, consecutive, interventional case series. PARTICIPANTS: One hundred forty-four patients with treatment-naïve neovascular AMD examined at 3 university hospitals. METHODS: After a loading phase of 3 monthly 2.0-mg IAIs, the patients were injected bimonthly with additional rescue injections performed for worsening...
March 2016: Ophthalmology
Fiona Pin Miao Lim, Chee Wai Wong, Boon Kwang Loh, Choi Mun Chan, Ian Yeo, Shu Yen Lee, Ranjana Mathur, Doric Wong, Tien Yin Wong, Chui Ming Gemmy Cheung
PURPOSE: To describe the prevalence and clinical characteristics of focal choroidal excavation (FCE) in patients with exudative maculopathy due to age-related macular degeneration with choroidal neovascularisation (AMD-CNV), polypoidal choroidal vasculopathy (PCV) and central serous chorioretinopathy (CSC). METHODS: Three hundred and forty-three patients (343 presenting eyes and 255 fellow unaffected eyes) from consecutive patients presenting with untreated AMD-CNV, PCV or CSC are prospectively recruited...
July 2016: British Journal of Ophthalmology
Jae Hui Kim, Young Suk Chang, Jong Woo Kim, Tae Gon Lee, Young Ju Lew
PURPOSE: To evaluate the prevalence of a visible suprachoroidal layer (SCL) on optical coherence tomography (OCT) in exudative age-related macular degeneration (AMD). MATERIALS AND METHODS: This retrospective study included 252 eyes of 252 patients with treatment-naive typical exudative AMD (n = 80), polypoidal choroidal vasculopathy (PCV) (n = 138) and retinal angiomatous proliferation (RAP) (n = 34). The presence of SCL was identified based on enhanced-depth imaging OCT images, and the prevalence was compared among the three disease groups...
May 2016: Current Eye Research
Se Joon Woo, Jeeyun Ahn, Margaux A Morrison, So Yeon Ahn, Jaebong Lee, Ki Woong Kim, Margaret M DeAngelis, Kyu Hyung Park
PURPOSE: To investigate the association of genetic and environmental factors, and their interactions in Korean patients with exudative age-related macular degeneration (AMD). METHODS: A total of 314 robustly characterized exudative AMD patients, including 111 PCV (polypoidal choroidal vasculopathy) and 154 typical choroidal neovascularization (CNV), and 395 control subjects without any evidence of AMD were enrolled. Full ophthalmologic examinations including fluorescein angiography (FA), indocyanine green angiography (ICG) and optical coherence tomography (OCT) were done, according to which patients were divided into either PCV or typical CNV...
2015: PloS One
Tiffany Lau, Ian Y Wong, Lawrence Iu, Jay Chhablani, Tao Yong, Koizumi Hideki, Jacky Lee, Raymond Wong
Optical coherence tomography (OCT) is a noninvasive imaging modality providing high-resolution images of the central retina that has completely transformed the field of ophthalmology. While traditional OCT has produced longitudinal cross-sectional images, advancements in data processing have led to the development of en-face OCT, which produces transverse images of retinal and choroidal layers at any specified depth. This offers additional benefit on top of longitudinal cross-sections because it provides an extensive overview of pathological structures in a single image...
May 2015: Indian Journal of Ophthalmology
Gabriel Coscas, Marco Lupidi, Florence Coscas, Fayçal Benjelloun, Jennifer Zerbib, Ali Dirani, Oudy Semoun, Eric H Souied
PURPOSE: To suggest a clinical distinction between idiopathic polypoidal choroidal vasculopathy (PCV) and secondary polyps associated with neovascular age-related macular degeneration (NV-AMD). METHODS: The study was a retrospective case series of 52 eyes of 52 consecutive patients (31 females and 21 males) diagnosed with PCV. Initial diagnosis was based on scanning laser ophthalmoscope-indocyanine green angiography (SLO-ICGA) in association with fluorescein angiography (FA) and optical coherence tomography (OCT)...
May 2015: Investigative Ophthalmology & Visual Science
Hyesun Kim, Sung Chul Lee, Sang Myung Kim, Ji Hwan Lee, Hyoung Jun Koh, Sung Soo Kim, Suk Ho Byeon, Min Kim, Christopher Seungkyu Lee
PURPOSE: To investigate the causes of acute spontaneous submacular hemorrhage with indocyanine green angiography (ICGA). METHODS: Retrospective observation case series. A total of 51 eyes from 51 patients with newly developed spontaneous submacular hemorrhage were enrolled. Best-corrected visual acuity (BCVA), fundus photography, fluorescein angiography, spectral domain optical coherence tomography (OCT), and ICGA at baseline were analyzed. The extent of hemorrhage using fundus photography, height of hemorrhage, and central foveal thickness measured by OCT was analyzed to compare the diagnostic and nondiagnostic groups...
2015: Ophthalmologica. Journal International D'ophtalmologie
Joo Youn Shin, Moonjung Choi, Byunghoon Chung, Suk Ho Byeon
PURPOSE: The purpose of the study was to compare the rates and characteristics of retinal pigment epithelial (RPE) tears between typical exudative age-related macular degeneration (tAMD) and polypoidal choroidal vasculopathy (PCV) after injection of intravitreal ranibizumab (IVR). METHODS: In total, 836 eyes from 784 patients with exudative AMD treated with IVR were analyzed. The presence, type, size, and height of pigment epithelial detachment (PED) in OCT before injection were evaluated, and the occurrence rate of RPE tears within three months of injection between tAMD and PCV was compared...
December 2015: Graefe's Archive for Clinical and Experimental Ophthalmology
Rui Hua, Limin Liu, Yuedong Hu, Lei Chen
To investigate the occurrence and progression of outer retinal tubulation (ORT) in Chinese patients after intravitreal ranibizumab injections, using spectral domain optical coherence tomography (SD-OCT) with eye tracking function. 15 age related macular degeneration (AMD) and 6 polypoidal choroidal vasculopathy (PCV) eyes of 21 patients were enrolled and assessed by SD-OCT. One patient received photodynamic therapy (PDT) previously, and all patients received intravitreal injections of ranibizumab. At baseline, only one AMD eye (4...
January 7, 2015: Scientific Reports
Rosa M Coco, M Rosa Sanabria, Melissa Castrejon, M Isabel Lopez-Galvez, Laura Monje-Fernandez, Marta Fernandez-Munoz, Alejandro Anton, Lourdes de Juan-Marcos, Sonia Villaron-Alvarez, Itziar Fernandez
BACKGROUND: The study aims to survey longstanding funduscopic and functional outcomes of age-related macular degeneration (AMD) after ranibizumab treatment and verify the accuracy of a new method to compare the retinal thickness measured with different optical coherence tomography (OCT) tools. METHODS: Case series included 314 eyes with 2-4 years of follow-up. Main Outcome Measures were visual acuity (VA), number of injections, retinal thickness, OCT morphology, and final macular funduscopic status...
2014: BMC Ophthalmology
Yu Kawashima, Akio Oishi, Akitaka Tsujikawa, Kenji Yamashiro, Masahiro Miyake, Naoko Ueda-Arakawa, Munemitsu Yoshikawa, Ayako Takahashi, Nagahisa Yoshimura
PURPOSE: To evaluate visual and anatomic outcomes in response to the conversion of treatment in patients with neovascular age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV) refractory to previous treatment. We also investigated the effect of genetic factors. METHODS: We recruited patients with AMD or PCV refractory to ranibizumab and initiated aflibercept treatment. Changes in the logarithm of minimum angle of resolution (logMAR) and central retinal thickness (CRT) measured using optical coherence tomography (OCT) 6 months after the conversion were compared between the AMD and PCV groups...
September 2015: Graefe's Archive for Clinical and Experimental Ophthalmology
Sang Jun Park, Bo Hyuck Kim, Kyu Hyung Park, Se Joon Woo
PURPOSE: To characterize punctate hyperfluorescence spot as common choroidopathy in central serous chorioretinopathy (CSC) and polypoidal choroidal vasculopathy (PCV). DESIGN: Cross-sectional retrospective study. METHODS: A total of 150 patients with 50 each allocated to CSC, PCV, and typical neovascular age-related macular degeneration (AMD) groups were included. Punctate hyperfluorescence spot was determined using mid-to late-phase indocyanine green angiography and subfoveal choroidal thickness by enhanced depth imaging optical coherence tomography...
December 2014: American Journal of Ophthalmology
Young-Joo Hong, Masahiro Miura, Myeong Jin Ju, Shuichi Makita, Takuya Iwasaki, Yoshiaki Yasuno
PURPOSE: To investigate exudative macular disease, multifunctional optical coherence tomography (MF-OCT) using a 1-μm probe band was developed. The clinical utility of MF-OCT was examined in a descriptive case series. METHODS: Ten eyes of nine subjects with exudative macular disease, including one eye with age-related macular degeneration (AMD), one eye with idiopathic neovascular maculopathy, and eight eyes with polypoidal choroidal vasculopathy (PCV), were investigated...
August 2014: Investigative Ophthalmology & Visual Science
Chui Ming Gemmy Cheung, Xiang Li, Ranjana Mathur, Shu Yen Lee, Choi Mun Chan, Ian Yeo, Boon Kwang Loh, Rachel Williams, Edmund Yick-Mun Wong, Doric Wong, Tien Yin Wong
OBJECTIVE: To study the treatment patterns and visual outcome over one year in Asian patients with choroidal neovascular membrane secondary to age-related macular degeneration (AMD-CNV) and polypoidal choroidal vasculopathy (PCV). DESIGN: Prospective cohort, non-interventional study. METHODS: 132 treatment-naïve patients who received treatment for AMD-CNV and PCV were included. All patients underwent standardized examination procedures including retinal imaging at baseline and follow-up...
2014: PloS One
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