Tiziana Annese, Patrizia Corsi, Simona Ruggieri, Roberto Tamma, Christian Marinaccio, Sabrina Picocci, Mariella Errede, Giorgina Specchia, Annamaria De Luca, Maria Antonia Frassanito, Vanessa Desantis, Angelo Vacca, Domenico Ribatti, Beatrice Nico
The blood-brain barrier (BBB) is altered in mdx mouse, an animal model to study Duchenne muscular dystrophy (DMD). Our previous work demonstrated that perivascular glial endfeet control the selective exchanges between blood and neuropil as well as the BBB development and integrity; the alterations of dystrophin and dystrophin-associated protein complex (DAPs) in the glial cells of mdx mouse, parallel damages of the BBB and increase in vascular permeability. The aim of this study was to improve our knowledge about brain cellular components in the mdx mouse through the isolation, for the first time, of the adult neural stem cells (ANSCs)...
May 1, 2016: Experimental Cell Research