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https://www.readbyqxmd.com/read/28222395/technetium-99m-radiolabeled-paclitaxel-as-an-imaging-probe-for-breast-cancer-in-vivo
#1
Liziane O F Monteiro, Renata S Fernandes, Luciano C Castro, Valbert N Cardoso, Mônica C Oliveira, Danyelle M Townsend, Alice Ferretti, Domenico Rubello, Elaine A Leite, André L B de Barros
The high incidence and mortality of breast cancer supports efforts to develop innovative imaging probes to effectively diagnose, evaluate the extent of the tumor, and predict the efficacy of tumor treatments while concurrently and selectively delivering anticancer agents to the cancer tissue. In the present study we described the preparation of technetium-99m ((99m)Tc)-labeled paclitaxel (PTX) and evaluated its feasibility as a radiotracer for breast tumors (4T1) in BALB/c mice. Thin Layer Chromatography (TLC) was used to determine the radiochemical purity and in vitro stability of (99m)Tc-PTX...
February 17, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28222215/epstein-barr-virus-specific-adoptive-immunotherapy-for-recurrent-metastatic-nasopharyngeal-carcinoma
#2
Julian Huang, Mark Fogg, Lori J Wirth, Heather Daley, Jerome Ritz, Marshall R Posner, Fred C Wang, Jochen H Lorch
BACKGROUND: Early-stage and intermediate stage nasopharyngeal cancer (NPC) generally carry a good prognosis, but for patients with recurrent, metastatic disease, options are limited. In the current study, the authors present a phase 1/2 study to evaluate the efficacy of Epstein-Barr virus (EBV)-stimulated cytotoxic T-lymphocyte (EBV-CTL) immunotherapy in this patient population. METHODS: Screening for patients with active, recurrent, metastatic EBV-associated NPC began in February 2007, and the study was closed to accrual in January 2012...
February 21, 2017: Cancer
https://www.readbyqxmd.com/read/28222086/equivalence-study-of-two-temperature-measurement-methods-in-febrile-adult-patients-with-cancer
#3
Tina M Mason, Abdelbaki Boubekri, Jennifer Lalau, Amy Patterson, Susan R Hartranft, Steven K Sutton
PURPOSE/OBJECTIVES: To assess equivalence of temperatures taken via temporal artery and oral methods in febrile inpatients with cancer.
. DESIGN: Repeated measures equivalence design.
. SETTING: 24-bed hematology-oncology unit and 36-bed blood and marrow transplantation unit at H. Lee Moffitt Cancer Center and Research Institute, a National Cancer Institute-designated comprehensive cancer center in Tampa, Florida.
. SAMPLE: Convenience sample of 58 febrile inpatients using 60 temperature measurements...
March 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/28221730/erratum-to-correct-lafay-cousin-et-al-clinical-pathological-and-molecular-characterization-of-infant-medulloblastomas-treated-with-sequential-high-dose-chemotherapy-pediatric-blood-cancer-2016-sep-63-9-1527-34
#4
https://www.readbyqxmd.com/read/28221716/ionic-self-assembled-platform-of-perylenediimide-sodium-dodecylsulfate-for-detection-of-spermine-in-clinical-samples
#5
Prabhpreet Singh, Lalit Singh Mittal, Gaurav Bhargava, Subodh Kumar
The detection and quantification of spermine in clinical practice is important for early diagnosis of many diseases. The chromatographic and immunoassay-based methods are commonly used. However, fluorescence-based assay could provide real time detection. Herein, we report synthesis and aggregation properties of dicationic perylene probe (DAB-PDI) and used DAB-PDI in developing fluorescent 'turn-on' ensemble for detection of spermine. The fluorescence of DAB-PDI (10 µM, Φ = 0.55) is efficiently quenched by negatively charged sodium dodecylsulfate (SDS) through formation of ionic self-assembled aggregates (charge ratio N/P = 9)...
February 21, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28220843/dusp1-promoter-methylation-in-peripheral-blood-leukocyte-is-associated-with-triple-negative-breast-cancer-risk
#6
Jing Li, Yanbo Chen, Hongyuan Yu, Jingshen Tian, Fengshun Yuan, Jialong Fan, Yupeng Liu, Lin Zhu, Fan Wang, Yashuang Zhao, Da Pang
DNA methylation is one of the most common epigenetic alterations, providing important information regarding cancer risk and prognosis. A case-control study (423 breast cancer cases, 509 controls) and a case-only study (326 cases) were conducted to evaluate the association of DUSP1 promoter methylation with breast cancer risk and clinicopathological characteristics. No significant association between DUSP1 methylation in peripheral blood leukocyte (PBL) DNA and breast cancer risk was observed. DUSP1 methylation was significantly associated with ER/PR-negative status; in particular, triple-negative breast cancer patients showed the highest frequency of DUSP1 methylation in both tumour DNA and PBL DNA...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28220143/venous-thromboembolism-in-children-with-cancer-and-blood-disorders
#7
REVIEW
Richard H Ko, Courtney D Thornburg
Venous thromboembolism (VTE) in children is multifactorial and most often related to a combination of inherited and acquired thrombophilias. Children with cancer and blood disorders are often at risk for VTE due to disease-related factors such as inflammation and abnormal blood flow and treatment-related factors such as central venous catheters and surgery. We will review risk factors for VTE in children with leukemia, lymphoma, and solid tumors. We will also review risk factors for VTE in children with blood disorders with specific focus on sickle cell anemia and hemophilia...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28220124/in-vivo-efficacy-of-umbilical-cord-blood-stem-cell-derived-nk-cells-in-the-treatment-of-metastatic-colorectal-cancer
#8
John P Veluchamy, Silvia Lopez-Lastra, Jan Spanholtz, Fenna Bohme, Nina Kok, Daniëlle A M Heideman, Henk M W Verheul, James P Di Santo, Tanja D de Gruijl, Hans J van der Vliet
Therapeutic monoclonal antibodies against the epidermal growth factor receptor (EGFR) act by inhibiting EGFR downstream signaling and by eliciting a natural killer (NK) cell-mediated antitumor response. The IgG1 mAb cetuximab has been used for treatment of RAS(wt) metastatic colorectal cancer (mCRC) patients, showing limited efficacy. In the present study, we address the potential of adoptive NK cell therapy to overcome these limitations investigating two allogeneic NK cell products, i.e., allogeneic activated peripheral blood NK cells (A-PBNK) and umbilical cord blood stem cell-derived NK cells (UCB-NK)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28219748/improved-antitumor-activity-and-reduced-toxicity-of-doxorubicin-encapsulated-in-poly-%C3%AE%C2%B5-caprolactone-nanoparticles-in-lung-and-breast-cancer-treatment-an-in-vitro-and-in-vivo-study
#9
Laura Cabeza, Raul Ortiz, Jose Prados, Ángel V Delgado, Maria J Martín-Villena, Beatriz Clares, Gloria Perazzoli, Jose M Entrena, Consolación Melguizo, Jose L Arias
Poly(ε-caprolactone) (PCL) nanoparticles (NPs) offer many possibilities for drug transport because of their good physicochemical properties and biocompatibility. Doxorubicin-loaded PCL NPs have been synthesized to try to reduce the toxicity of doxorubicin (DOX) for healthy tissues and enhance its antitumor effect in two tumor models, breast and lung cancer, which have a high incidence in the global population. PCL NPs were synthesized using a modified nanoprecipitation solvent evaporation method. The in vitro toxicity of PCL NPs was evaluated in breast and lung cancer cell lines from both humans and mice, as was the inhibition of cell proliferation and cell uptake of DOX-loaded PCL NPs compared to free DOX...
February 17, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28219368/lower-blood-pressure-and-risk-of-cisplatin-nephrotoxicity-a-retrospective-cohort-study
#10
Kazumi Komaki, Tetsuro Kusaba, Mai Tanaka, Hiroshi Kado, Yayoi Shiotsu, Masahiro Matsui, Atsushi Shiozaki, Hiroshi Nakano, Takeshi Ishikawa, Hitoshi Fujiwara, Hideyuki Konishi, Yoshito Itoh, Satoaki Matoba, Keiichi Tamagaki
BACKGROUND: The pathophysiological mechanisms of cisplatin nephrotoxicity include the reduction of renal blood flow, as well as tubular epithelial cell toxicity. The objective of this study was to investigate the influence of lower blood pressure and decreased food intake on the incidence of cisplatin nephrotoxicity. METHODS: We conducted a retrospective cohort study at a university hospital between 2011 and 2012. We identified hospitalized adult patients with head and neck cancer, esophageal cancer, or gastric cancer, who received intravenous cisplatin administration...
February 20, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28219253/in-vitro-and-in-vivo-evaluation-of-macromolecular-prodrug-gc-fua-based-nanoparticle-for-hepatocellular-carcinoma-chemotherapy
#11
Can Huang, Na-Mei Li, Pei Gao, Sa Yang, Qian Ning, Wen Huang, Zhi-Ping Li, Peng-Ju Ye, Li Xiang, Dong-Xiu He, Xiang-Wen Tan, Cui-Yun Yu
A novel type of macromolecular prodrug delivery system is reported in this research. The N-galactosylated-chitosan-5-fluorouracil acetic acid conjugate (GC-FUA) based nanoparticle delivery system was evaluated in vitro and in vivo. Biocompatibility of GC-FUA-NPs was screened by BSA adsorption test and hemolysis activity examination in vitro. Cytotoxicity and cellular uptake study in HepG2 and A549 cells demonstrated that compared to free 5-Fu, the GC-FUA-NPs play great function in killing cancer cells for the cell endocytosis mediated by asialoglycoprotein receptor (ASGPR), which overexpresses on the cell surface...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28219214/-analysis-of-risk-factors-for-postsurgical-gastroparesis-syndrome-pgs-after-operation-for-gastric-cancer
#12
D L Liu, X W Zhang, F Q Lyu
Objective: To investigate the risk factors for postsurgical gastroparesis syndrome (PGS) after surgery for stomach cancer. Methods: A total of 684 patients with gastric cancer who underwent surgery for stomach cancer from Jan. 1, 2010 to Dec. 31, 2014 in Tai'an Tumor Prevention and Treatment Hospital, including 475 males and 209 females, with an average age of 59.9 years were identified and included in this study. There were 206 cases of gastric cardia and gastric fundus cancers and 478 cases of gastric antrum cancer...
February 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28219213/-clinical-application-value-of-prognostic-nutritional-index-for-predicting-survival-in-patients-with-advanced-non-small-cell-lung-cancer
#13
W J Xu, Y M Kang, L Zhou, F F Chen, Y H Song, C Q Zhang
Objective: To explore the clinical application value of prognostic nutritional index(PNI) for predicting overall survival(OS) in patients with advanced non-small cell lung cancer (NSCLC). Methods: 123 patients with histologically confirmed non-small cell lung cancer were enrolled in this study, and their clinical and laboratory data were reviewed. The PNI was calculated as 10×serum albumin value+ 5×total lymphocyte countin peripheral blood.Univariate and multivariate analyses were used to identify the potential prognostic factors for advanced NSCLC...
February 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28218826/synthesis-and-antiproliferative-effect-of-ethyl-4-4-substitutedpiperidin-1-yl-benzylpyrrolo-1-2-a-quinoxaline-carboxylate-derivatives-on-human-leukemic-cells
#14
Jean Guillon, Vanessa Desplat, Marian Vincenzi, Romain Lucas, Stéphane Moreau, Solène Savrimoutou, Noel Pinaud, David Bigat, Elodie Enriquez, Mathieu Marchivie, Sylvain Routier, Pascal Sonnet, Filomena Rossi, Luisa Ronga
Acute leukemia is a hematological malignancy with high incidence and recurrence rates, and is characterized by an accumulation of blasts in bone marrow due to proliferation of immature lymphoid or myeloid cells associated with a blockade of differentiation. The heterogeneity of leukemia led to look for new specific molecules for leukemia subtypes or even for therapy-resistant cases. Among heterocyclic derivatives that attracted attention due to their large spread biological activities, we have focused our interest towards the pyrrolo[1,2-a]quinoxaline heterocyclic framework that has been previously identified as an interesting scaffold for antiproliferative activities against various human cancer cell lines...
February 20, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28218734/-lesions-detected-in-six-spanish-colorectal-cancer-screening-population-based-programmes-cribea-project-spain
#15
Isabel Portillo Villares, Eunate Arana-Arri, Isabel Idigoras Rubio, Josep Alfons Espinás Piñol, Francisco Pérez Riquelme, Mariola de la Vega Prieto, Alvaro González Aledo, Elena Oceja Setien, Mercedes Vanaclocha Espi, Josefa Ibáñez Cabanell, Dolores Salas Trejo
OBJECTIVE: In this study, the results of six Colorectal Cancer Screening Population Programmes are shown (Catalonia, Valence, Murcia, Cantabria, the Basque Country and the Canary Islands collected between 2005 and 2012. These programmes use the faeces occult blood test (FOBt) biennial. Objective: To determine and compare the results of lesions detected by the programmes, participation, sex, age and test used. METHODS: Retrospective cohort study based on people invited, aged between 50-74 years, in at least a complete round...
February 20, 2017: Revista Española de Salud Pública
https://www.readbyqxmd.com/read/28218664/determination-of-vegfr-2-kdr-604a-g-polymorphism-in-pancreatic-disorders
#16
Vlad Pădureanu, Mihail Virgil Boldeanu, Ioana Streaţă, Mihai Gabriel Cucu, Isabela Siloşi, Lidia Boldeanu, Maria Bogdan, Anca Ştefania Enescu, Maria Forţofoiu, Aurelia Enescu, Elena Mădălina Dumitrescu, Dragoş Alexandru, Valeriu Marian Şurlin, Mircea Cătălin Forţofoiu, Ileana Octavia Petrescu, Florin Petrescu, Mihai Ioana, Marius Eugen Ciurea, Adrian Săftoiu
Pancreatic disorders have a high prevalence worldwide. Despite the fact that screening methods became more effective and the knowledge we have nowadays about pancreatic diseases has enhanced, their incidence remains high. Our purpose was to determine whether single nucleotide polymorphism (SNP) of VEGFR-2/KDR (vascular endothelial growth factor receptor 2/kinase insert domain receptor) influences susceptibility to develop pancreatic pathology. Genomic DNA was extracted from blood samples collected from patients diagnosed with acute pancreatitis (n = 110), chronic pancreatitis (n = 25), pancreatic cancer (n = 82) and healthy controls (n = 232)...
February 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28218487/radiolabelled-polymeric-materials-for-imaging-and-treatment-of-cancer-quo-vadis
#17
REVIEW
Kritee Pant, Ondřej Sedláček, Robin A Nadar, Martin Hrubý, Holger Stephan
Owing to their tunable blood circulation time and suitable plasma stability, polymer-based nanomaterials hold a great potential for designing and utilising multifunctional nanocarriers for efficient imaging and effective treatment of cancer. When tagged with appropriate radionuclides, they may allow for specific detection (diagnosis) as well as the destruction of tumours (therapy) or even customization of materials, aiming to both diagnosis and therapy (theranostic approach). This review provides an overview of recent developments of radiolabelled polymeric nanomaterials (natural and synthetic polymers) for molecular imaging of cancer, specifically, applying nuclear techniques such as positron emission tomography (PET) and single-photon emission computed tomography (SPECT)...
February 20, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28218384/clinical-significance-of-circulating-tumor-cells-in-patients-with-small-cell-lung-cancer
#18
Yu-Li Wang, Chun-Hua Liu, Jing Li, Xiao-Ping Ma, Ping Gong
BACKGROUND: This study investigated the correlation of the presence of circulating tumor cells (CTCs) with clinical characteristics, and the predictive value of CTCs for progression-free survival (PFS) in patients with small-cell lung cancer (SCLC). METHODS: Samples were obtained from 42 patients with SCLC before and after the first cycle of chemotherapy. CTCs were quantitated by negative immunomagnetic enrichment and immunocytochemistry using anti-CD45 and anti-pancytokeratin antibodies...
February 15, 2017: Tumori
https://www.readbyqxmd.com/read/28218293/plasma-exosome-profiling-of-cancer-patients-by-a-next-generation-systems-biology-approach
#19
Valeriy Domenyuk, Zhenyu Zhong, Adam Stark, Nianqing Xiao, Heather A O'Neill, Xixi Wei, Jie Wang, Teresa T Tinder, Sonal Tonapi, Janet Duncan, Tassilo Hornung, Andrew Hunter, Mark R Miglarese, Joachim Schorr, David D Halbert, John Quackenbush, George Poste, Donald A Berry, Günter Mayer, Michael Famulok, David Spetzler
Technologies capable of characterizing the full breadth of cellular systems need to be able to measure millions of proteins, isoforms, and complexes simultaneously. We describe an approach that fulfils this criterion: Adaptive Dynamic Artificial Poly-ligand Targeting (ADAPT). ADAPT employs an enriched library of single-stranded oligodeoxynucleotides (ssODNs) to profile complex biological samples, thus achieving an unprecedented coverage of system-wide, native biomolecules. We used ADAPT as a highly specific profiling tool that distinguishes women with or without breast cancer based on circulating exosomes in their blood...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28218157/depression-in-cancer-patients-undergoing-chemotherapy-in-a-tertiary-care-hospital-of-north-bengal-india
#20
Sutanay Bhattacharyya, Sharmistha Bhattacherjee, Tanuka Mandal, Dilip Kumar Das
BACKGROUND: Detection of cancer and subsequent chemotherapy can lead to clinical depression in many cancer patients. OBJECTIVES: The study was conducted to find out the extent of depression in cancer patients undergoing chemotherapy and determine the factors associated with depression. METHODS: A cross-sectional descriptive study was conducted at the Chemotherapy Day Care Centre of North Bengal Medical College and Hospital from May to June 2013...
January 2017: Indian Journal of Public Health
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