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Endothelin

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https://www.readbyqxmd.com/read/29924890/targeting-mmp-13-in-bronchial-epithelial-repair
#1
Christopher Howell, James R Smith, Janis K Shute
BACKGROUND: Viral infection of the bronchial epithelium disrupts the barrier properties of the epithelium in healthy individuals and those with lung disease. Repair of the bronchial epithelium is dependent of the formation of a provisional fibrin matrix and migration of epithelial cells to cover denuded areas, followed by proliferation and differentiation. OBJECTIVE: The objective was to test the hypothesis that poly I:C, a model of viral infection, limits epithelial repair through the stimulated release of matrix metalloproteinase-13 (MMP-13)...
June 20, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29913121/association-of-baseline-big-endothelin-1-level-with-long-term-prognosis-among-cardiac-resynchronization-therapy-recipients
#2
Shengwen Yang, Zhimin Liu, Shangyu Liu, Ligang Ding, Keping Chen, Wei Hua, Shu Zhang
BACKGROUND: Serum concentration of big endothelin-1 (ET-1) has prognostic significance in heart failure. However, its prognostic value in cardiac resynchronization therapy (CRT) recipients has not been well-characterized. METHODS: A cohort of 367 consecutive patients who received CRT between January 2010 and December 2015 were enrolled, and categorized into three groups according to baseline big ET-1 tertiles: big ET-1 ≤ 0.34 pmol/L (N = 119), big ET-1 between 0...
June 15, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29906506/high-resolution-crystal-structure-of-substrate-free-human-neprilysin
#3
Stephen Moss, Vasanta Subramanian, K Ravi Acharya
Neprilysin is a transmembrane M13 zinc metalloprotease responsible for the degradation of several biologically active peptides including insulin, enkephalin, substance P, bradykinin, endothelin-1, neurotensin and amyloid-β. The protein has received attention for its role in modulating blood pressure responses with its inhibition producing an antihypertensive response. To date, several inhibitor bound crystal structures of the human neprilysin extracellular domain have been determined, but, a structure free of bound inhibitor or substrate has yet to be reported...
June 12, 2018: Journal of Structural Biology
https://www.readbyqxmd.com/read/29904040/a-pilot-trial-to-examine-the-changes-in-carotid-arterial-inflammation-in-renal-transplant-recipients-as-assessed-by-18f-fluorodeoxyglucose-18f-fdg-positron-emission-tomography-computed-tomography-pet-ct
#4
Hye Eun Yoon, Yaeni Kim, Sang Dong Kim, Jin Kyoung Oh, Yong-An Chung, Seok Joon Shin, Chul Woo Yang, Suk Min Seo
BACKGROUND Inflammatory activity of the artery can be assessed by measuring 18F-fluorodeoxyglucose (18F-FDG) uptake with positron emission tomography computed tomography (PET/CT). Improvement in vascular function after renal transplantation has been reported, but no studies have used 18F-FDG PET/CT to examine the changes in vascular inflammation. This study investigated the changes in the inflammatory activity in the carotid artery after renal transplantation in patients with chronic kidney disease (CKD). MATERIAL AND METHODS 18F-FDG PET/CT was performed before and at 4 months after transplantation...
June 15, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29903197/-effect-and-mechanism-of-three-kinds-of-drinking-water-on-blood-pressure-of-hypertensive-mice
#5
Qian Sun, Ronghe Chen, Fan Xin, Guohong Ruan
OBJECTIVE: To explore the effect of three kinds of drinking water and its possible mechanism on blood pressure of hypertensive mice. METHODS: The water quality parameters were measured for three kinds of drinking water, and the parameters includedtotal dissolved solids( TDS), oxygen consumed( OC), p H, oxidation reduction potential( ORP), electric conductivity( EC), dissolved hydrogen, calcium and magnesium. Establishment of mouse model of high blood pressure by using N'-nitro-L-arginine methyl ester hydrochloride( L-NAME) for 30 days...
November 2017: Wei Sheng Yan Jiu, Journal of Hygiene Research
https://www.readbyqxmd.com/read/29901088/fasudil-preserves-lung-endothelial-function-and-reduces-pulmonary-vascular-remodeling-in-a-rat-model-of-end%C3%A2-stage-pulmonary-hypertension-with-left-heart-disease
#6
Rulin Zhuang, Jinfu Wu, Fang Lin, Lu Han, Xiaoting Liang, Qingshu Meng, Yuyu Jiang, Zhulin Wang, Aixue Yue, Yuying Gu, Huimin Fan, Xiaohui Zhou, Zhongmin Liu
Pulmonary hypertension (PH) due to left heart disease (LHD) is a common condition associated with significant morbidity. It contributes to the elevation of pulmonary vascular resistance and mean pulmonary pressure, eventually leading to heart failure and even mortality. The present study aimed to explore the potential efficacy of late and long‑term treatment with a Rho‑kinase (ROCK) signaling inhibitor, namely fasudil, in a rat model of end‑stage PH‑LHD. The PH‑LHD model was established by supracoronary aortic banding, and the effect of fasudil treatment on the progression of PH‑LHD was monitored...
June 13, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29896248/a-study-of-the-correlation-of-insulin-resistance-and-leptin-with-inflammatory-factors-and-vascular-endothelial-injury-in-t2dm-patients-with-chd
#7
Jie Zhang, Jing Jin, Jilun Liu, Yajun He, Peng Zhang, Wucheng Ye, Wei Zhu, Mingliang Li
The purpose of this study was to explore the correlation of insulin resistance (IR) and leptin with inflammatory factors and vascular endothelial injury in patients with type 2 diabetes mellitus (T2DM) complicated with coronary heart disease (CHD) was explored. One hundred and fifty normal patients (normal group), 150 patients with pure T2DM (T2DM group) and 150 patients with T2DM complicated with coronary heart disease (T2DM + CHD group) were selected from Xi'an No. 5 Hospital. All the participants met our inclusion criteria...
July 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29896159/blockade-of-endothelin-1-receptor-type-b-ameliorates-glucose-intolerance-and-insulin-resistance-in-a-mouse-model-of-obstructive-sleep-apnea
#8
Jan Polak, Naresh M Punjabi, Larissa A Shimoda
Obstructive sleep apnea (OSA) is associated with insulin resistance (IR) and glucose intolerance. Elevated endothelin-1 (ET-1) levels have been observed in OSA patients and in mice exposed to intermittent hypoxia (IH). We examined whether pharmacological blockade of type A and type B ET-1 receptors (ETA and ETB ) would ameliorate glucose intolerance and IR in mice exposed to IH. Subcutaneously implanted pumps delivered BQ-123 (ETA antagonist; 200 nmol/kg/day), BQ-788 (ETB antagonist; 200 nmol/kg/day) or vehicle (saline or propyleneglycol [PG]) for 14 days in C57BL6/J mice (10/group)...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29893909/interleukin-6-and-tumor-growth-factor-%C3%AE-are-risk-factors-for-idiopathic-epistaxis
#9
Soheila Rahmanzadeh-Shahi, Ali Golshiri-Isfahani, Mahmood Sheikh Fathollahi, Mohammadtaghi Rezayati, Reza Bahramabadi, Mohammadreza Afrooz, Gholamreza Asadikaram, Derek Kennedy, Mohammad Kazemi Arababadi
Objective: To evaluate the serum levels of interleukin (IL)-6, IL-8, tumor necrosis factor (TNF)-α, tumor growth factor (TGF)-β, endothelin, and immunoglobulin (Ig)E in patients with idiopathic epistaxis, compared with healthy control individuals. Methods: Serum levels of IL-6, IL-8, TNF-α, TGF-β, endothelin, and IgE were evaluated in 110 patients with idiopathic epistaxis and 100 healthy controls using the enzyme-linked immunosorbent assay (ELISA) technique...
June 9, 2018: Laboratory Medicine
https://www.readbyqxmd.com/read/29893190/metformin-preconditioning-of-human-induced-pluripotent-stem-cell-derived-neural-stem-cells-promotes-their-engraftment-and-improves-post-stroke-regeneration-and-recovery
#10
Fares Ould-Brahim, Sailendra Nath Sarma, Charvi Syal, Kevin Jiaqi Lu, Matthew Seegobin, Anthony Carter, Matthew S Jeffers, Carole Doré, William Stanford, Dale Corbett, Jing Wang
While transplantation of hiPSC-derived neural stem cells (hiPSC-NSCs) shows therapeutic potential in animal stroke models, major concerns for translating hiPSC therapy to the clinic are efficacy and safety. Therefore, there is a demand to develop an optimal strategy to enhance the engraftment and regenerative capacity of transplanted hiPSC-NSCs in order to produce fully differentiated neural cells to replace lost brain tissues. Metformin, an FDA approved drug, is an optimal neuroregenerative agent that not only promotes NSC proliferation but also drives NSC towards differentiation...
June 12, 2018: Stem Cells and Development
https://www.readbyqxmd.com/read/29892146/upregulation-of-endothelin-1-endothelin-a-receptor-expression-correlates-with-heparanase-expression-in-ovarian-carcinoma
#11
Nungki Anggorowati, Ahmad Ghozali, Irianiwati Widodo, Dwi Cahyani Ratna Sari, Muhammad Mansyur Romi, Nur Arfian
Background: Heparanase and endothelin-1/endothelin A receptor (ET-1/ETA R) expressions increase in cancer. This condition enhances tumor progression and correlates with poor survival. Limited data are documented regarding the role of heparanase and ET-1/ETA R in epithelial ovarian cancer (EOC). We sought to characterize the correlation between heparanase and ET-1/ETA R in EOC. Methods: Thirty patients with benign and malignant ovarian neoplasms were recruited in this study...
May 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29891771/role-of-magnesium-deficiency-in-promoting-atherosclerosis-endothelial-dysfunction-and-arterial-stiffening-as-risk-factors-for-hypertension
#12
REVIEW
Krasimir Kostov, Lyudmila Halacheva
Arterial hypertension is a disease with a complex pathogenesis. Despite considerable knowledge about this socially significant disease, the role of magnesium deficiency (MgD) as a risk factor is not fully understood. Magnesium is a natural calcium antagonist. It potentiates the production of local vasodilator mediators (prostacyclin and nitric oxide) and alters vascular responses to a variety of vasoactive substances (endothelin-1, angiotensin II, and catecholamines). MgD stimulates the production of aldosterone and potentiates vascular inflammatory response, while expression/activity of various antioxidant enzymes (glutathione peroxidase, superoxide dismutase, and catalase) and the levels of important antioxidants (vitamin C, vitamin E, and selenium) are decreased...
June 11, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29888323/circulating-neurotoxic-5-ht2a-receptor-agonist-autoantibodies-in-adult-type-2-diabetes-with-parkinson-s-disease
#13
Mark B Zimering
Aims: To test whether circulating neurotoxic autoantibodies increase in adult type 2 diabetes mellitus with Parkinson's disease (PD) or dementia. To identify the G-protein coupled receptor on neuroblastoma cells mediating neural inhibitory effects in diabetic Parkinson's disease plasma autoantibodies. To determine the mechanism of accelerated neuroblastoma cell death and acute neurite retraction induced by diabetic Parkinson's disease and dementia autoantibodies. Methods: Protein-A eluates from plasma of twelve older adult male diabetic patients having Parkinson's disease (n=10) or dementia (n=2), and eight age-matched control diabetic patients were tested for ability to cause accelerated N2A neuroblastoma cell death and acute neurite retraction...
2018: Journal of Endocrinology and Diabetes
https://www.readbyqxmd.com/read/29886166/attenuation-of-the-degenerative-effects-of-endothelin-1-on-cartilaginous-endplate-cells-by-the-endothelin-receptor-antagonist-bq-123-via-the-wnt-%C3%AE-catenin-signaling-pathway
#14
Wei Yuan, Zhen-Xi Li, Cheng-Long Zhao, Tian-Hui Hou, Si-Wang Hu, Wei-Bo Liu, Feng-Lai Yuan, Jian-Ru Xiao
BACKGROUND: Context: Endothelin-1 (ET-1) is an inflammatory mediator associated with cartilage endplate (CEP) degeneration in the intervertebral disc. SOX9 is down-regulated during CEP degeneration, along with its targets, collagen II and aggrecan. Wnt/β-catenin signaling is associated with CEP degeneration and a downstream target of SOX9; however, the precise mechanism of CEP degeneration and the role of ET-1 are largely unknown. PURPOSE: The purpose of the study was to evaluate the influence of the endothelin A receptor antagonist, BQ-123, on ET-1-induced effects on cartilaginous endplate cells (CECs) associated with CEP degeneration via the Wnt/β-catenin signaling pathway...
June 7, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29885909/pam-antagonists-a-better-way-to-block-pathological-receptor-signaling
#15
REVIEW
Terry Kenakin, Ryan T Strachan
Seven transmembrane receptor (7TMR) responses are modulated by orthosteric and allosteric ligands to great therapeutic advantage. Here we introduce a unique class of negative allosteric modulator (NAM) - the positive allosteric modulator (PAM)-antagonist - that increases the affinity of the receptor for the agonist but concomitantly decreases agonist efficacy when cobound. Notably, the reciprocation of allosteric energy causes the orthosteric agonist to increase the affinity of the receptor for the PAM-antagonist; thus, this modulator seeks out and destroys agonist-bound receptor complexes...
June 6, 2018: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/29885334/compartmentalized-cyclic-nucleotides-have-opposing-effects-on-regulation-of-hypertrophic-phospholipase-c%C3%AE%C2%B5-signaling-in-cardiac-myocytes
#16
Craig A Nash, Loren M Brown, Sundeep Malik, Xiaodong Cheng, Alan V Smrcka
In cardiac myocytes activation of an exchange factor activated by cAMP (Epac) leads to activation of phospholipase Cε (PLCε)-dependent hydrolysis of phosphatidylinositol 4-phosphate (PI4P) in the Golgi apparatus a process critical for development of cardiac hypertrophy. Here we show that β-adrenergic receptor (βAR) stimulation does not stimulate this pathway in the presence of the broad spectrum phosphodiesterase (PDE) inhibitor IBMX, but selective PDE3 inhibition revealed βAR-dependent PI4P depletion...
June 6, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29884912/sex-specific-contributions-of-endothelin-to-hypertension
#17
REVIEW
Eman Y Gohar, David M Pollock
PURPOSE OF REVIEW: Men and women differ in the prevalence, pathophysiology and control rate of hypertension in an age-dependent manner. The renal endothelin system plays a central role in sex differences in blood pressure regulation by control of sodium excretion and vascular function. Improving our understanding of the sex differences in the endothelin system, especially in regard to blood pressure regulation and sodium homeostasis, will fill a significant gap in our knowledge and may identify sex-specific therapeutic targets for management of hypertension...
June 8, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29883369/genomics-of-fibromuscular-dysplasia
#18
REVIEW
Silvia Di Monaco, Adrien Georges, Jean-Philippe Lengelé, Miikka Vikkula, Alexandre Persu
Fibromuscular Dysplasia (FMD) is &ldquo;an idiopathic, segmental, non-atherosclerotic and non-inflammatory disease of the musculature of arterial walls, leading to stenosis of small and medium-sized arteries&rdquo; (Persu, et al; 2014). FMD can lead to hypertension, arterial dissections, subarachnoid haemorrhage, stroke or mesenteric ischemia. The pathophysiology of the disease remains elusive. While familial cases are rare (<5%) in contemporary FMD registries, there is evidence in favour of the existence of multiple genetic factors involved in this vascular disease...
May 21, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29882756/short-term-exposure-to-high-sucrose-levels-near-weaning-has-a-similar-long-lasting-effect-on-hypertension-as-a-long-term-exposure-in-rats
#19
Mariana Villegas-Romero, Vicente Castrejón-Téllez, Israel Pérez-Torres, María Esther Rubio-Ruiz, Elizabeth Carreón-Torres, Eulises Díaz-Díaz, Leonardo Del Valle-Mondragón, Verónica Guarner-Lans
Adverse conditions during early developmental stages permanently modify the metabolic function of organisms through epigenetic changes. Exposure to high sugar diets during gestation and/or lactation affects susceptibility to metabolic syndrome or hypertension in adulthood. The effect of a high sugar diet for shorter time lapses remains unclear. Here we studied the effect of short-term sucrose ingestion near weaning (postnatal days 12 and 28) (STS) and its effect after long-term ingestion, for a period of seven months (LTS) in rats...
June 6, 2018: Nutrients
https://www.readbyqxmd.com/read/29881931/recent-findings-in-the-genetics-of-blood-pressure-how-to-apply-in-practice-or-is-a-moonshot-required
#20
REVIEW
Sandosh Padmanabhan, Alisha Aman, Anna F Dominiczak
PURPOSE OF REVIEW: Hypertension is recognised as the biggest contributor to the global burden of disease, but it is controlled in less than a fifth of patients worldwide, despite being relatively easy to detect and the availability of inexpensive safe generic drugs. Blood pressure is regulated by a complex network of physiologic pathways with currently available drugs targeting key receptors or enzymes in the top pathways. Major advances in the dissection of both monogenic and polygenic determinants of blood pressure regulation and variation have not resulted in rapid translation of these discoveries into clinical applications or precision medicine...
June 7, 2018: Current Hypertension Reports
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