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Bingqiao Huang, Wanggang Zhang, Linting Wei, Sheping Chen, Ting Wang, Rongguo Fu
Silent information regulator family protein 1 (Sirt1) has gained attention for protective effects against cardiovasc diseases. Vascular smooth muscle endothelin type B (ETB ) receptors are related to the pathogenesis of cardiovascular diseases. Elevated oxidized low-density lipoprotein (ox-LDL) is associated with atherosclerosis. This study will investgate whether resveratrol (a Sirt1 activator, Res) is involved in oxidized low density lipoprotein (ox-LDL)-mediated- regulation of ETB receptors in rat superior mesenteric arteries (SMA)...
September 18, 2018: European Journal of Pharmacology
Pragya Sharma, Yu Dong, Virend K Somers, Timothy E Peterson, Yuebo Zhang, Shihan Wang, Guangxi Li, Prachi Singh
Vascular dysfunction and insulin resistance (IR) are associated with obstructive sleep apnea (OSA), which is characterized by frequent episodes of nocturnal intermittent hypoxia (IH). While it is recognized that the balance between vasoconstrictive (endothelin-1) and vasodilatory molecules (nitric oxide, NO) determine vascular profile, molecular mechanisms contributing to vascular dysfunction and IR in OSA are not completely understood. Caveolin-1 is a membrane protein which regulates endothelial nitric oxide synthase (eNOS) activity which is responsible for NO generation and cellular insulin-signaling...
September 20, 2018: Scientific Reports
Stanford E Mwasongwe, Bessie Young, Aurelian Bidulescu, Mario Sims, Adolfo Correa, Solomon K Musani
BACKGROUND: Few investigations have evaluated the incremental usefulness of multiple biomarkers representing varying physiological pathways for predicting risk of renal outcomes in African Americans. DESIGN, SETTING, PARTICIPANTS, AND MEASUREMENTS: We related a multi-marker panel to incident chronic kidney disease (CKD) and rapid kidney function decline (RKFD) in 2813 Jackson Heart Study participants without prevalent CKD at exam 1 (2000-2004) and with complete assays at exam 1 for 9 biomarkers: adiponectin, aldosterone, B-natriuretic peptide [BNP], cortisol, high sensitivity C-reactive protein (hsCRP), endothelin, homocysteine, plasma renin activity and mass...
September 20, 2018: BMC Nephrology
Kseniia Porshneva, Diana Papiernik, Mateusz Psurski, Marcin Nowak, Rafał Matkowski, Marcin Ekiert, Magdalena Milczarek, Joanna Banach, Joanna Jarosz, Joanna Wietrzyk
Vascular endothelial dysfunction and platelet activation play a key role in tumor metastasis, and therefore both of these processes are considered important therapeutic targets in cancer. The aim of our studies was to analyze anti-metastatic activity of combination therapy using nitric oxide donor DETA/NO and antiplatelet drug clopidogrel. Nitric oxide acts as a vasoprotective mediator, while clopidogrel inhibits ADP-mediated platelet aggregation. 4T1-luc2-tdTomato cell line transplanted intravenously (i.v...
September 20, 2018: Molecular Pharmaceutics
Yi-Chen Yu, Ying Jiang, Meng-Meng Yang, Sai-Nan He, Xia Xi, Ye-Tao Xu, Wen-Sheng Hu, Qiong Luo
BACKGROUND: Increasing epidemiological studies have confirmed the association between maternal preeclampsia and elevated blood pressure in their offspring. Though case-control or cohort studies have demonstrated long-term outcomes for the offspring of preeclampsia, it is still a question that how these changes were caused by genetic reasons or by preeclampsia itself. OBJECTIVE: In our study, we explored the potential epigenetic regulation of delta-like homolog 1-maternally expressed gene 3 (DLK1-MEG3) region in human umbilical vein endothelial cells (HUVECs), and its connection with endothelium-derived factors...
September 17, 2018: Journal of Hypertension
Martin Houde, Adel Schwertani, Hanène Touil, Louisane Desbiens, Otman Sarrhini, Roger Lecomte, Martin Lepage, Hugo Gagnon, Shinji Takai, Gunnar Pejler, Danielle Jacques, Fernand Gobeil, Robert Day, Pedro D'Orléans-Juste
Chymase, a mast cell serine protease involved in the generation of multiple cardiovascular factors, such as angiotensin II and endothelin-1 (ET-1), is elevated and participates in tissue degeneration after permanent myocardial infarction (PMI). Anesthetized 4-month old male wild-type (WT) C57BL/6J mice and mouse mast cell protease-4 knockout (mMCP-4 KO) congeners were subjected to ligation of the left anterior descending (LAD) coronary artery. A group of mice was then subjected to Kaplan-Meier 28-day survival analysis...
2018: Frontiers in Pharmacology
Guanhua Li, Wen Jiang, Yu Zhang, Xiaohua Zhang, Jimei Chen, Jian Zhuang, Chengbin Zhou
Purpose: To investigate the influence and possible pathophysiological mechanism of pulsatile cardiopulmonary bypass (CPB) in various frequencies in pediatric patients undergoing congenital cardiac surgery. Patients and methods: Clinical data and hemodynamic parameters were collected in 80 patients who underwent congenital cardiac surgeries and were perfused in different settings: pulsatile perfusion (PP) in frequencies of 30 beats/min, PP 60 beats/min, PP 100 beats/min and non-pulsatile perfusion (NP)...
2018: Therapeutics and Clinical Risk Management
Natasha Najwa Nor Arfuzir, Renu Agarwal, Igor Iezhitsa, Puneet Agarwal, Sabrilhakim Sidek, Nafeeza Mohd Ismail
Endothelin-1 (ET-1), a potent vasoconstrictor, is involved in retinal vascular dysregulation and oxidative stress in glaucomatous eyes. Taurine (TAU), a naturally occurring free amino acid, is known for its neuroprotective and antioxidant properties. Hence, we evaluated its neuroprotective properties against ET-1 induced retinal and optic nerve damage. ET-1 was administered intravitreally to Sprague-Dawley rats and TAU was injected as pre-, co- or post-treatment. Animals were euthanized seven days post TAU injection...
November 2018: Neural Regeneration Research
Fabrizio Grosjean, Mara De Amici, Catherine Klersy, Gianluca Marchi, Antonio Sciortino, Federica Spaltini, Maurizio Pin, Valentina Grazioli, Anna Celentano, Benedetta Vanini, Giorgia Testa, Vincenzo Sepe, Teresa Rampino, Andrea Maria D'Armini
OBJECTIVES: The only curative treatment for chronic thromboembolic pulmonary hypertension (CTEPH) is pulmonary endarterectomy (PEA). PEA requires cardiopulmonary bypass (CPB) which is associated with a high acute kidney injury (AKI) risk. Circulating endothelin-1 (ET-1) levels are elevated in CTEPH, and ET-1 plays a pivotal role in AKI. Because AKI is burdened by high morbidity and mortality, we aimed to evaluate the association between preoperative ET-1 and the risk to develop AKI in CTEPH individuals who undergo PEA...
September 18, 2018: Journal of Nephrology
Shan Feng, Li Zou, Hongjin Wang, Ran He, Ke Liu, Huifeng Zhu
Lipopolysaccaride (LPS) directly or indirectly injures brain microvascular endothelial cells (BMECs) and damages the intercellular tight junction that gives rise to altered blood-brain barrier (BBB) permeability. Catalpol plays a protective role in LPS-induced injury, but whether catalpol protects against LPS-caused damage of BBB permeability and the underlying mechanism remain to be delineated. Prophylactic protection with catalpol (5 mg/kg, i.v.) consecutively for three days reversed the LPS-induced damage of BBB by decreased Evans Blue (EB) leakage and restored tight junctions in C57 mice...
September 17, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Jessica E Spiewak, Emily J Bain, Jin Liu, Kellie Kou, Samantha L Sturiale, Larissa B Patterson, Parham Diba, Judith S Eisen, Ingo Braasch, Julia Ganz, David M Parichy
Fishes of the genus Danio exhibit diverse pigment patterns that serve as useful models for understanding the genes and cell behaviors underlying the evolution of adult form. Among these species, zebrafish D. rerio exhibit several dark stripes of melanophores with sparse iridophores that alternate with light interstripes of dense iridophores and xanthophores. By contrast, the closely related species D. nigrofasciatus has an attenuated pattern with fewer melanophores, stripes and interstripes. Here we demonstrate species differences in iridophore development that presage the fully formed patterns...
September 18, 2018: PLoS Genetics
Barbara Hausott, Lars Klimaschewski
Clinical trials applying growth factors to alleviate symptoms of patients with neurological disorders have largely been unsuccessful in the past. As an alternative approach, growth factor receptors or components of their signal transduction machinery may be targeted directly. In recent years, the search for intracellular signaling integrator downstream of receptor tyrosine kinases provided valuable novel substrates. Among them are the Sprouty proteins which mainly act as inhibitors of growth factor-dependent neuronal and glial signaling pathways...
September 17, 2018: Molecular Neurobiology
Jacob Y Cao, Kathryn M Wales, Rachael Cordina, Edmund M T Lau, David S Celermajer
BACKGROUND: Pulmonary hypertension complicating left heart disease (PH-LHD) is the most common cause of PH. Off-label use of pulmonary arterial hypertension (PAH) medications for PH-LHD is prevalent, despite a lack of clinical data supporting their use. METHODS: A systematic review and meta-analysis was performed. Comprehensive search of all available literature to date identified ten randomised, placebo controlled trials comprising 439 treated (Phosphodiesterase 5 inhibitors: n = 206; guanylate cyclase stimulators: n = 132; endothelin receptor antagonists: n = 101) and 338 placebo patients...
September 12, 2018: International Journal of Cardiology
Jennifer Joan Ryan, Douglas Allen Hanes, Jamie Corroon, Jan Taylor, Ryan D Bradley
OBJECTIVE: To prospectively examine the long-term safety of a cardiovascular health dietary supplement by assessing a comprehensive set of safety measures. DESIGN: Single-arm, open-label study. LOCATION: National University of Natural Medicine, Portland, OR. SUBJECTS: Thirty adults with screening blood pressure readings consistent with prehypertension or stage I hypertension. INTERVENTION: One caplet per day of a dietary supplement for 6 months...
September 14, 2018: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
Bruno Vergès
We have a large body of evidence showing that hyperglycemia is a cardiovascular risk factor and that its reduction decreases the risk for cardiovascular events. Indeed, epidemiological studies have clearly shown that hyperglycemia is a strong and independent factor for cardiovascular disease. In addition, we have many pathophysiological studies demonstrating the direct role of hyperglycemia in the development of atherosclerosis. Hyperglycemia, by stimulating protein kinase C, increases the production of pro-inflammatory cytokines, of adhesion molecules and of endothelin-1 and, by stimulating the polyol pathway, promotes the oxidative stress...
September 12, 2018: La Presse Médicale
Anna E Stanhewicz, Megan M Wenner, Nina S Stachenfeld
Diseases of the cardiovascular system are the leading cause of morbidity and mortality in men and women in developed countries, and CVD is becoming more prevalent in developing countries. Atherosclerotic cardiovascular disease (CVD) prevalence in men is greater than in women until menopause, when the prevalence of CVD increases in women until it exceeds that of men. Endothelial function is a barometer of vascular health and a predictor of atherosclerosis that may provide insights into sex differences in CVD, as well as how and why CVD risk drastically changes with menopause...
September 14, 2018: American Journal of Physiology. Heart and Circulatory Physiology
Nasrien E Ibrahim, Rajat Gupta, Asya Lyass, Yiwei Li, Shreya Shrestha, Cian P McCarthy, Hanna K Gaggin, Roland R J van Kimmenade, Joseph M Massaro, Ralph B D'Agostino, James L Januzzi
BACKGROUND: Endothelin-1 (ET-1) is a vasoconstrictor produced by vascular endothelial cells and may play a role in risk for development of coronary artery disease (CAD) and heart failure (HF). In a cohort of 1084 patients referred for coronary angiography, we investigated cross-sectional associations between ET-1 concentrations and prevalent CAD, as well as value of ET-1 for prognostication of future cardiovascular events. METHODS: Associations between ET-1 and presence/ severity of CAD were assessed...
September 13, 2018: Clinical Chemistry
Andrzej Cacko, Agnieszka Kondracka, Monika Gawałko, Renata Główczyńska, Krzysztof J Filipiak, Zbigniew Bartoszewicz, Grzegorz Opolski, Marcin Grabowski
Successful risk stratification is necessary for optimum management of patients after acute coronary syndrome (ACS). The aim of the study was to evaluate the role of novel biochemical markers in the prediction of adverse cardiovascular events in stable patients several years after ACS.The study group was randomly selected from all ACS patients treated with reperfusion therapy between 2002 and 2003 at 1st Department of Cardiology, Medical University of Warsaw, Poland. All patients were readmitted to hospital between 2010 and 2011 for clinical and biochemical cardiovascular risk factors assessment and were prospectively observed for 30-months follow-up...
September 2018: Medicine (Baltimore)
Leidiane Mazzardo-Martins, Daiana Cristina Salm, Elisa C Winkelmann-Duarte, Júlia Koerich Ferreira, Daniela Dero Lüdtke, Kamilla Pamplona Frech, Luiz Augusto Oliveira Belmonte, Verônica Vargas Horewicz, Anna Paula Piovezan, Francisco José Cidral-Filho, Ari Ojeda Ocampo Moré, Daniel Fernandes Martins
The original version of this article contains an error. The Author Francisco José Cidral-Filho incorrectly listed as Francisco José Cidra-Filho. The correct spelling is presented above. The original article has been corrected.
September 13, 2018: Pflügers Archiv: European Journal of Physiology
Erika I Boesen
Renal ischemia-reperfusion (IR) injury and acute kidney injury (AKI) increase the risk of developing hypertension, with T cells suspected as a possible mechanistic link. Endothelin promotes renal T cell infiltration in several diseases, predominantly via the ETA receptor, but its contribution to renal T cell infiltration following renal IR injury is poorly understood. To test whether ETA receptor activation promotes T cell infiltration of the kidney following IR injury, male C57BL/6 mice were treated with the ETA receptor antagonist ABT-627 or vehicle, commencing 2 days prior to unilateral renal IR injury...
September 2018: Physiological Reports
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