A K Berner, O Brouwers, R Pringle, I Klaassen, L Colhoun, C McVicar, S Brockbank, J W Curry, T Miyata, M Brownlee, R O Schlingemann, C Schalkwijk, A W Stitt
AIMS/HYPOTHESIS: Methylglyoxal (MG) is an important precursor for AGEs. Normally, MG is detoxified by the glyoxalase (GLO) enzyme system (including component enzymes GLO1 and GLO2). Enhanced glycolytic metabolism in many cells during diabetes may overpower detoxification capacity and lead to AGE-related pathology. Using a transgenic rat model that overexpresses GLO1, we investigated if this enzyme can inhibit retinal AGE formation and prevent key lesions of diabetic retinopathy. METHODS: Transgenic rats were developed by overexpression of full length GLO1...
March 2012: Diabetologia