Lea Wagmann, Lilian H J Richter, Tobias Kehl, Franziska Wack, Madeleine Pettersson Bergstrand, Simon D Brandt, Alexander Stratford, Hans H Maurer, Markus R Meyer
The market of new psychoactive substances (NPS) is characterized by a high turnover and thus provides several challenges for analytical toxicology. The analysis of urine samples often requires detailed knowledge about metabolism given that parent compounds either may be present only in small amounts or may not even be excreted. Hence, knowledge of the metabolism of NPS is a prerequisite for the development of reliable analytical methods. The main aim of this work was to elucidate for the first time the pooled human liver S9 fraction metabolism of the nine d-lysergic acid diethylamide (LSD) derivatives 1-acetyl-LSD (ALD-52), 1-propionyl-LSD (1P-LSD), 1-butyryl-LSD (1B-LSD), N6 -ethyl-nor-LSD (ETH-LAD), 1-propionyl-N6 -ethyl-nor-LSD (1P-ETH-LAD), N6 -allyl-nor-LSD (AL-LAD), N-ethyl-N-cyclopropyl lysergamide (ECPLA), (2'S,4'S)-lysergic acid 2,4-dimethylazetidide (LSZ), and lysergic acid morpholide (LSM-775) by means of liquid chromatography coupled to high-resolution tandem mass spectrometry...
July 2019: Analytical and Bioanalytical Chemistry