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Novel psychoactive substance

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https://www.readbyqxmd.com/read/28718892/methoxetamine-affects-brain-processing-involved-in-emotional-response-in-rats
#1
M T Zanda, P Fadda, S Antinori, M di Chio, W Fratta, C Chiamulera, L Fattore
BACKGROUND AND PURPOSE: Methoxetamine (MXE) is a novel psychoactive substance that is emerging on the Internet and induces dissociative effects and acute toxicity. Yet, its pharmacological effects are still poorly investigated. EXPERIMENTAL APPROACH: We examined a range of behavioural effects induced by acute intraperitoneal administration of MXE (0.5-5 mg/kg) in rats, and whether it causes rapid neuroadaptive molecular changes. KEY RESULTS: MXE (0...
July 18, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28713291/an-expanding-world-of-novel-psychoactive-substances-opioids
#2
REVIEW
Jolanta B Zawilska
The abuse of novel psychoactive substances (NPS) has been increasing dramatically worldwide since late 2000s. By the end of 2015, more than 560 NPS had been reported to the European Monitoring Centre for Drugs and Drug Addiction. Although the most popular compounds are synthetic cannabinoids and psychostimulatory derivatives of cathinone (so-called β-keto-amphetamines), novel synthetic opioids have recently emerged on the recreational drug market. They include fentanyl (a potent narcotic analgesic) and its analogs (e...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28692400/developing-syndromic-surveillance-to-monitor-and-respond-to-adverse-health-events-related-to-psychoactive-substance-use-methods-and-applications
#3
Michelle L Nolan, Hillary V Kunins, Ramona Lall, Denise Paone
INTRODUCTION: Recent increases in drug overdose deaths, both in New York City and nationally, highlight the need for timely data on psychoactive drug-related morbidity. We developed drug syndrome definitions for syndromic surveillance to monitor drug-related emergency department (ED) visits in real time. MATERIALS AND METHODS: We used 2012 archived syndromic surveillance data from New York City hospitals to develop definitions for psychoactive drug-related syndromes...
July 2017: Public Health Reports
https://www.readbyqxmd.com/read/28667187/impact-of-novel-psychoactive-substances-on-clinical-and-forensic-toxicology-and-global-public-health
#4
Marilyn A Huestis, Simon D Brandt, Suman Rana, Volker Auwärter, Michael H Baumann
No abstract text is available yet for this article.
June 30, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28662837/a-snapshot-of-novel-psychoactive-substances-legal-highs-use-in-london
#5
Claire Norman, Geraldine A Lee
No abstract text is available yet for this article.
June 26, 2017: International Emergency Nursing
https://www.readbyqxmd.com/read/28657189/utility-of-web-search-query-data-in-testing-theoretical-assumptions-about-mephedrone
#6
Máté Kapitány-Fövény, Zsolt Demetrovics
OBJECTIVE: With growing access to the Internet, people who use drugs and traffickers started to obtain information about novel psychoactive substances (NPS) via online platforms. This paper aims to analyze whether a decreasing Web interest in formerly banned substances-cocaine, heroin, and MDMA-and the legislative status of mephedrone predict Web interest about this NPS. METHODS: Google Trends was used to measure changes of Web interest on cocaine, heroin, MDMA, and mephedrone...
May 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28657188/from-concept-ion-to-life-after-death-the-grave-the-natural-history-and-life-cycle-s-of-novel-psychoactive-substances-nps
#7
John Martin Corkery, Laura Orsolini, Duccio Papanti, Fabrizio Schifano
A range of information needs should be met in order to better understand and predict the longevity/existence of novel psychoactive substances (NPS). This conceptual paper argues that one way of assessing how long a molecule may be around is to document how the life cycles or natural histories of 'traditional' drugs and NPS evolve. The earliest indication of the possible appearance of a new substance might be evidenced on the DeepWeb. However, this means they are less visible, in line with the clandestine nature of drug use and supply...
May 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28657187/an-insight-into-the-deep-web-why-it-matters-for-addiction-psychiatry
#8
Laura Orsolini, Duccio Papanti, John Corkery, Fabrizio Schifano
OBJECTIVE: Nowadays, the web is rapidly spreading, playing a significant role in the marketing or sale or distribution of "quasi" legal drugs, hence facilitating continuous changes in drug scenarios. The easily renewable and anarchic online drug-market is gradually transforming indeed the drug market itself, from a "street" to a "virtual" one, with customers being able to shop with a relative anonymity in a 24-hr marketplace. The hidden "deep web" is facilitating this phenomenon. The paper aims at providing an overview to mental health's and addiction's professionals on current knowledge about prodrug activities on the deep web...
May 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28657186/novel-psychoactive-substances-nps-use-in-severe-mental-illness-smi-patients-potential-changes-in-the-phenomenology-of-psychiatric-diseases
#9
Giuseppe Bersani, Elisabeth Prevete
OBJECTIVE: Literature is quite poor about the clinical effects of novel psychoactive substances (NPS) and the long-term consequences of NPS use in psychiatric patients. Consequently, it is of the greatest interest to examine which effects NPS can exert in patients with previous severe mental illness (SMI), such as psychotic patients. The aim of this work was a comprehensive review about NPS use in patients with SMI. METHODS: We searched Medline or PubMed for relevant English-language citations and reviews describing relationships between NPS use and mental disorders, as well as for the main groups of substances and associated psychiatric manifestations...
May 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28657180/4-4-dimethylaminorex-4-4-dmar-serotoni-misuse-a-web-based-study
#10
Barbara Loi, Mire Zloh, Maria Antonietta De Luca, Nicholas Pintori, John Corkery, Fabrizio Schifano
BACKGROUND: 4,4'-DMAR (4,4'-dimethylaminorex; "Serotoni") is a potent stimulant drug that has recently been associated with a number of fatalities in Europe. Over the last few years, online communities have emerged as important resources for disseminating levels of technical knowledge on novel psychoactive substances. OBJECTIVE: Analysing the information provided by the fora communities on 4,4'-DMAR use, additionally critical reviewing the available evidence-based literature on this topic...
May 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28657179/novel-psychoactive-substances-shedding-new-lights-on-the-ever-changing-drug-scenario-and-the-associated-health-risks
#11
EDITORIAL
O Corazza, A C Parrott, Z Demetrovics
No abstract text is available yet for this article.
May 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28657178/1-cyclohexyl-x-methoxybenzene-derivatives-novel-psychoactive-substances-seized-on-the-internet-market-synthesis-and-in-vivo-pharmacological-studies-in-mice
#12
Anna Fantinati, Andrea Ossato, Sara Bianco, Isabella Canazza, Fabio De Giorgio, Claudio Trapella, Matteo Marti
INTRODUCTION: Among novel psychoactive substances notified to EMCDDA and Europol were 1-cyclohexyl-x-methoxybenzene stereoisomers (ortho, meta, and para). These substances share some structural characteristics with phencyclidine and tramadol. Nowadays, no information on the pharmacological and toxicological effects evoked by 1-cyclohexyl-x-methoxybenzene are reported. The aim of this study was to investigate the effect evoked by each one stereoisomer on visual stimulation, body temperature, acute thermal pain, and motor activity in mice...
May 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28635020/fentanyl-novel-derivative-related-deaths
#13
Arianna Giorgetti, Carmela Centola, Raffaele Giorgetti
OBJECTIVE: Fentanyl (FEN) is a potent, synthetic narcotic used as an anaesthetic and a pain reliever, but also illegally manufactured. For diversion purpose, it is being steadily modified to produce new analogous compounds and derivatives (FENS), categorised as novel psychoactive substances. While potential FEN abuse is already known, even in the absence of a clear lethal dosage, there is still a shortage of data on its derivatives. METHODS: A literature review of FENS-related deaths was performed, to better understand potential damage and future perspectives of FEN congeners...
May 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28634759/current-applications-of-high-resolution-mass-spectrometry-for-the-analysis-of-new-psychoactive-substances-a-critical-review
#14
REVIEW
Daniel Pasin, Adam Cawley, Sergei Bidny, Shanlin Fu
The proliferation of new psychoactive substances (NPS) in recent years has resulted in the development of numerous analytical methods for the detection and identification of known and unknown NPS derivatives. High-resolution mass spectrometry (HRMS) has been identified as the method of choice for broad screening of NPS in a wide range of analytical contexts because of its ability to measure accurate masses using data-independent acquisition (DIA) techniques. Additionally, it has shown promise for non-targeted screening strategies that have been developed in order to detect and identify novel analogues without the need for certified reference materials (CRMs) or comprehensive mass spectral libraries...
June 20, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28631526/lifetime-experience-with-classic-psychedelics-predicts-pro-environmental-behavior-through-an-increase-in-nature-relatedness
#15
Matthias Forstmann, Christina Sagioglou
In a large-scale ( N = 1487) general population online study, we investigated the relationship between past experience with classic psychedelic substances (e.g. LSD, psilocybin, mescaline), nature relatedness, and ecological behavior (e.g. saving water, recycling). Using structural equation modeling we found that experience with classic psychedelics uniquely predicted self-reported engagement in pro-environmental behaviors, and that this relationship was statistically explained by people's degree of self-identification with nature...
June 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28631432/profile-effects-and-toxicity-of-novel-psychoactive-substances-a-systematic-review-of-quantitative-studies
#16
Sulaf Assi, Nargilya Gulyamova, Kinda Ibrahim, Paul Kneller, David Osselton
OBJECTIVE: To investigate the profile, effects, and toxicity of novel psychoactive substances (NPS). METHODS: A systematic literature review was conducted between May 2015 and February 2016 and included 19 databases. Search terms included "novel psychoactive substance(s)," "effect(s)," and "toxicity" and their synonyms. Studies included were those from any country, in any language, and between January 2007 and April 2015. Studies published before 2007 and those regarding the synthesis of NPS were excluded...
June 19, 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28631373/the-risk-of-violence-associated-with-novel-psychoactive-substance-misuse-in-patients-presenting-to-acute-mental-health-services
#17
Abu Shafi, Paul Gallagher, Neil Stewart, Giovanni Martinotti, Ornella Corazza
Novel psychoactive substance (NPS) availability is increasing at a phenomenal rate and so is their associated misuse. Currently, the harms associated with NPS misuse are unclear. This report presents the initial findings of a continuing study looking into the impact of NPS misuse on admissions to an acute mental health facility in London. Violence preadmission and violence during admission have been found to be significant in NPS misusers compared to non-NPS substance misusers. Our findings have important consequences for acute mental health, emergency, and public health services...
June 19, 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28618002/novel-psychoactive-substance-use-among-treatment-seeking-opiate-users-the-role-of-life-events-and-psychiatric-symptoms
#18
Máté Kapitány-Fövény, Judit Farkas, Patrícia Andrea Pataki, Anna Kiss, Janka Horváth, Róbert Urbán, Zsolt Demetrovics
OBJECTIVE: Over the past 5 years, a shift to the use of novel psychoactive substances (NPS) has been observed among opioid users. The aim of this study was to assess the potential reasons for NPS use among treatment-seeking patients receiving opiate substitution therapy. METHOD: A structured questionnaire was filled out by a sample of 198 opiate dependent patients of Hungary's National Institute of Psychiatry and Addiction. This questionnaire assessed demographics, treatment characteristics, lifetime substance use, potential reasons for NPS use, negative life events (Life Events Scale), and psychiatric symptoms (Brief Symptom Inventory)...
May 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28600805/assessing-the-impact-of-a-temporary-class-drug-order-on-ethylphenidate-related-infections-among-people-who-inject-drugs-in-lothian-scotland-an-interrupted-time-series-analysis
#19
Alan Yeung, Amanda Weir, Hannah Austin, Kirsty Morrison, Donald Inverarity, Jim Sherval, Naomi Henderson, Shruti Joshi, Roisin Ure, Andrew McAuley
BACKGROUND AND AIMS: In April 2015, the UK government enacted a temporary class drug order (TCDO) on ethylphenidate in response to reported harms associated with its use, in particular an outbreak of infections among people who inject drugs (PWID) in Lothian, Scotland. This study assesses the effect that the TCDO had on reducing the most common infections identified during the outbreak; Streptococcus pyogenes (S. pyogenes) and Staphylococcus aureus (S. aureus). DESIGN: The outbreak was split into a pre-intervention period (35 weeks) and a post-intervention period (26 weeks) based around the date of the TCDO...
June 10, 2017: Addiction
https://www.readbyqxmd.com/read/28578694/worldwide-legislative-challenges-related-to-psychoactive-drugs
#20
REVIEW
Carolina Negrei, Bianca Galateanu, Miriana Stan, Cristian Balalau, Mircea Lucian Bogdan Dumitru, Eren Ozcagli, Concettina Fenga, Leda Kovatsi, Domniki Fragou, Aristidis Tsatsakis
The discovery of a "new" psychoactive substance is a relatively exceptional event, while the regulatory response usually involved the assessment of risks to public health and inclusion of the novel substance in the national list of controlled substances. However, in recent years we have witnessed the rapid emergence of new chemical substances, which elude international control and pose a challenge to existing processes and a threat to the credibility of control systems. We currently review and present characteristics of these legal and illegal new substances and issues regarding their global monitoring and regulatory measures already taken, or in the process of being taken, for their control...
June 2, 2017: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
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