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https://www.readbyqxmd.com/read/28551474/rgo-au-nps-n-doped-cnts-supported-on-nickel-foam-as-an-anode-for-enzymatic-biofuel-cells
#1
He Zhang, Lingling Zhang, Yujie Han, You Yu, Miao Xu, Xueping Zhang, Liang Huang, Shaojun Dong
In this study, three-dimensional reduced graphene oxide/Au NPs/nitrogen-doped carbon nanotubes (RGO/Au NPs/N-doped CNTs) assembly supported on nickel foam was utilized as an anode for enzymatic biofuel cells (EBFCs). 3D RGO/Au NPs was obtained by electrodepositing reduced graphene oxide on nickel foam (Ni foam), while Au NPs were co-deposited during the process. Afterwards, nitrogen doped CNTs (N-CNTs) were allowed to grow seamlessly on the surfaces of 3D RGO/Au NPs via a simple chemical vapor deposition (CVD) process...
May 17, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28551157/synthesis-and-characterization-of-a-bimodal-nanoparticle-based-on-the-host-guest-self-assembly-for-targeted-cellular-imaging
#2
Huihui Wang, Dongsheng Sun, Han Liao, Yanfang Wang, Shan Zhao, Ying Zhang, Guojun Lv, Xiaojun Ma, Yang Liu, Guangwei Sun
Multimodal imaging provides distinct advantages over traditional single modal imaging. The combined modalities of magnetic resonance imaging (MRI) and near-infrared imaging (NIR), in particular, provide a powerful tool for tumor diagnosis. In this study, a bimodal MRI and NIR self-assembled supramolecular nanoparticle was developed via the self-assembly of host-guest interactions between hyaluronic acid-β-cyclodextrin (HA-CD) and amantadine (Ad)-modified imaging agents (Gd-DOTA and NIR cyanine dye Cy7). The supramolecular HA-CD-GC nanoparticles (NPs) were characterized by transmission electron microscopy (TEM), Zeta potential, and dynamic light-scattering (DLS) experiments...
August 15, 2017: Talanta
https://www.readbyqxmd.com/read/28551143/screening-of-tio2-and-au-nanoparticles-in-cosmetics-and-determination-of-elemental-impurities-by-multiple-techniques-dls-sp-icp-ms-icp-ms-and-icp-oes
#3
Inmaculada de la Calle, Mathieu Menta, Marlène Klein, Fabienne Séby
Cosmetics are part of the daily life of most of the people. Thus, a complete characterization of the products we applied in our skin is necessary. In this work, an analytical investigation of a wide variety of cosmetics from the point of view of total element content and metallic nanoparticles (NPs) has been performed. Firstly, we analyzed the total element content by ICP-MS and ICP-OES after acid digestion as an assessment of the presence of metal impurities. Prohibited elements in cosmetics, according to the European Commission regulation No 1223/2009, were not detected, and only elements mentioned in the label were found (e...
August 15, 2017: Talanta
https://www.readbyqxmd.com/read/28551058/-anesthesia-recovery-comparison-between-remifentanil-propofol-and-remifentanil-desflurane-guided-by-bispectral-index-%C3%A2-monitoring
#4
Raphael Grossi Rocha, Eduardo Giarola Almeida, Lara Moreira Mendes Carneiro, Natália Farias de Almeida, Walkíria Wingester Vilas Boas, Renato Santiago Gomez
BACKGROUND AND OBJECTIVES: There is a strong demand for fast and predictable anesthesia recovery with few side effects. Choice of the hypnotic agent could impact on that. This study investigated the differences between recoveries after remifentanil-propofol and remifentanil-desflurane anesthesias guided by bispectral index (BIS(®)). METHODS: Forty patients were randomly assigned into 2 groups according to the anesthesia technique applied: remifentanil-propofol (REM-PRO) and remifentanil-desflurane (REM-DES)...
May 25, 2017: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/28550938/reassessment-of-antibiotic-therapy-in-hospitals
#5
M Lucas, J-M Germain, E Rémy, M Lottin, M Etienne, P Czernichow, V Merle
INTRODUCTION: French national guidelines state that antibiotic therapies should be reassessed between 48 and 72hours after treatment initiation and that reassessment of antibiotic therapy (RA) must be recorded in patients' files. OBJECTIVE: To determine whether RA is performed and recorded in patients' files in hospitals in a region of France. METHODS: Setting: hospitals participating in the National nosocomial infection point- prevalence survey (NPS) in Upper-Normandy, France...
May 24, 2017: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/28550773/susceptibility-resistance-and-resilience-of-anammox-biomass-to-nanoscale-copper-stress
#6
Zheng-Zhe Zhang, Hai-Yan Hu, Jia-Jia Xu, Zhi-Jian Shi, Yang-Yang Shen, Man-Ling Shi, Ren-Cun Jin
The increasing use of engineered nanoparticles (NPs) poses an emerging challenge to biological wastewater treatment. The long-term impact of CuNPs on anaerobic ammonium oxidation (anammox) process was firstly investigated in this study. The nitrogen removal capacity of anammox reactor was nearly deprived within 30days under the stress of 5.0mgL(-1) CuNPs and the relative abundance of anammox bacteria (Ca. Kuenenia) was decreased from 29.59% to 17.53%. Meanwhile, copper resistance genes associated with the Cus, Cop and Pco systems were enriched to eliminate excess intracellular copper...
May 15, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28550746/zn-doped-cdo-nanoparticles-structural-morphological-optical-photocatalytic-and-anti-bacterial-properties
#7
Vinod Kumar Gupta, Ali Fakhri, Shiva Tahami, Shilpi Agarwal
Pure and zinc-doped CdO NPs (Zn-CdO NPs) were synthesized through a facile co-precipitation method. The structural, morphology, chemical composition, optical and antibacterial activity of the NPs were studied with respect to pure and Zn-doped CdO concentration (0-7.5mol.%). Scanning electron microscope (SEM) images reveal that pure and Zn-doped CdO NPs were in the nano-scale regime with different crystalline morphology. The energy dispersive X-ray spectroscopy (EDS) spectrum predicts the presence of Cadmium (Cd), Zinc (Zn) and Oxygen (O) in the prepared samples...
May 21, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28550154/an-amperometric-h2o2biosensor-based-on-hemoglobin-nanoparticles-immobilized-onto-a-gold-electrode
#8
Vinay Narwal, Neelam Yadav, Manisha Thakur, Chandra Shekhar Pundir
The nanoparticles (NPs) of hemoglobin (Hb) were prepared by desolvation method and characterized by transmission electron microscopy (TEM), ultraviolet (UV) spectroscopy and Fourier-transform infrared spectroscopy (FTIR). An amperometric H2O2 biosensor was constructed by immobilizing HbNPs covalently onto a polycrystalline Au electrode (AuE). HbNPs/AuE was characterized by scanning electron microscopy (SEM), cyclic voltammetry (CV) and electrochemical impedance spectra (EIS) before and after immobilization of HbNPs...
May 26, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28549973/targeted-delivery-of-rosmarinic-acid-across-the-blood-brain-barrier-for-neuronal-rescue-using-polyacrylamide-chitosan-poly-lactide-co-glycolide-nanoparticles-with-surface-cross-reacting-material-197-and-apolipoprotein-e
#9
Yung-Chih Kuo, Rajendiran Rajesh
Rosmarinic acid-loaded polyacrylamide-chitosan-poly(lactide-co-glycolide) nanoparticles (RA-PAAM-CH-PLGA NPs) were grafted with cross-reacting material 197 (CRM197) and apolipoprotein E (ApoE) for targeting of the blood-brain barrier (BBB) and rescuing degenerated neurons. The polymeric nanocarriers were prepared by microemulsion, solvent diffusion, grafting, and surface modification, and CRM197-ApoE-RA-PAAM-CH-PLGA NPs were used to treat human brain-microvascular endothelial cells, RWA264.7 cells, and Aβ-insulted SK-N-MC cells...
May 23, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28548278/neuropeptide-s-precursor-knockout-mice-display-memory-and-arousal-deficits
#10
Xiaobin Liu, Wei Si, Celia Garau, Kay Jüngling, Hans-Christian Pape, Stefan Schulz, Rainer K Reinscheid
Activation of Neuropeptide S (NPS) signaling has been found to produce arousal, wakefulness, anxiolytic-like behaviors and enhanced memory formation. In order to further study physiological functions of the NPS system, we generated NPS precursor knockout mice by homologous recombination in embryonic stem cells. NPS(-/-) mice were viable, fertile, and anatomically normal, when compared to their wildtype and heterozygous littermates. The total number of NPS neurons - although no longer synthesizing the peptide - was not affected by the knockout, as analyzed in NPS(-/-) /NPS(EGFP) double-transgenic mice...
May 26, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28548180/efficient-all-p-type-heterojunction-photocathodes-for-photoelectrochemical-water-splitting
#11
Xue Lu, Zhifeng Liu
In this paper, Co3O4 nanostructures with different morphologies (nanoparticles (NPs), nanosheets (NSs) and nanocubes (NCs)) are directly grown on an ITO substrate using a hydrothermal method. Sb2S3 is loaded onto Co3O4 to construct a Co3O4/Sb2S3 heterojunction, which is used as an all p-type photocathode for photoelectrochemical (PEC) water splitting for the first time. The specific morphologies of Co3O4 have been discussed in detail. The improved PEC properties of the Co3O4/Sb2S3 heterojunction are characterized...
May 26, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28547860/inhibition-of-melanoma-metastasis-by-dual-peptide-plga-nps
#12
Denise Costa Arruda, Thaís Dolzany de Oliveira, Patrícia Harume Fukuda Cursino, Vera Susana Carneiro Maia, Rodrigo Berzaghi, Luiz R Travassos, Dayane Batista Tada
Despite the positive results observed in vitro and in vivo, clinical trials with bioactive peptides are generally hampered by their fast degradation in the biological system. Two bioactive peptides, P20 (CSSRTMHHC) and the combined peptide C (CVNHPAFACGYGHTMYYHHYQHHL) have been identified as anticancer therapeutics. Combined peptide C consists of peptide C (CVNHPAFAC), a tumor-homing peptide, conjugated to the antiangiogenic peptide HTMYYHHYQHHL with a GYG. In this work, PLGA NPs with peptide C were applied as a dual-peptide carrier for application in cancer therapy...
May 25, 2017: Biopolymers
https://www.readbyqxmd.com/read/28546953/perspective-highlights-on-biodegradable-polymeric-nanosystems-for-targeted-therapy-of-solid-tumors
#13
REVIEW
Marziyeh Fathi, Jaleh Barar
Introduction: Polymeric nanoparticles (NPs) formulated using biodegradable polymers offer great potential for development of de novo drug delivery systems (DDSs) capable of delivering a wide range of bioactive agents. They can be engineered as advanced multifunctional nanosystems (NSs) for simultaneous imaging and therapy known as theranostics or diapeutics. Methods: A brief prospective is provided on biomedical importance and applications of biodegradable polymeric NSs through reviewing the recently published literature...
2017: BioImpacts: BI
https://www.readbyqxmd.com/read/28546070/efficient-loading-of-ethionamide-in-cyclodextrin-based-carriers-offers-enhanced-solubility-and-inhibition-of-drug-crystallization
#14
Jitendra Wankar, Giuseppina Salzano, Elisabetta Pancani, Gabor Benkovics, Milo Malanga, Francesco Manoli, Ruxandra Gref, Eva Fenyvesi, Ilse Manet
Ethionamide (ETH) is a second line antitubercular drug suffering from poor solubility in water and strong tendency to crystallize. These drawbacks were addressed by loading ETH in β-cyclodextrin (βCyD)-based carriers. The drug was incorporated in a molecular state avoiding crystallization even for long-term storage and obtaining a tenfold increased solubility up to 25mM. The binding of ETH to polymeric βCyD nanoparticles (pβCyD NPs) was investigated in neutral aqueous medium by means of solubility phase diagrams, circular dichroism (CD) and UV-vis absorption and compared with the corresponding βCyD monomer...
May 22, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28545321/virus-detection-by-pcr-following-vaccination-of-naive-calves-with-intranasal-or-injectable-multivalent-modified-live-viral-vaccines
#15
Paul H Walz, Benjamin W Newcomer, Kay P Riddell, Daniel W Scruggs, Victor S Cortese
We evaluated duration of PCR-positive results following administration of modified-live viral (MLV) vaccines to beef calves. Twenty beef calves were randomly assigned to either group 1 and vaccinated intranasally with a MLV vaccine containing bovine alphaherpesvirus 1 (BoHV-1), bovine respiratory syncytial virus (BRSV), and bovine parainfluenza virus 3 (BPIV-3), or to group 2 and vaccinated subcutaneously with a MLV vaccine containing bovine viral diarrhea virus 1 and 2 (BVDV-1, -2), BoHV-1, BRSV, and BPIV-3...
May 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28544816/analytical-characterization-of-three-cathinone-derivatives-4-mpd-4%C3%A2-f-php-and-bk-epdp-purchased-as-bulk-powder-from-online-vendors
#16
Orapan Apirakkan, Anca Frinculescu, Trevor Shine, Mark C Parkin, Agostino Cilibrizzi, Nunzianda Frascione, Vincenzo Abbate
Novel emerging drugs of abuse, also referred as new psychoactive substances (NPS), constitute an ever-changing mixture of chemical compounds designed to circumvent legislative controls by means of chemical modifications of previously banned recreational drugs. One of such class, synthetic cathinones, namely β-keto derivatives of amphetamines, has been largely abused over the past decade. A number of new synthetic cathinones are detected each year, either in bulk powders/crystals or in biological matrices. It is therefore important to continuously monitor the supply of new synthetic derivatives and promptly report them...
May 23, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28544761/composites-of-bacterial-cellulose-and-small-molecule-decorated-gold-nanoparticles-for-treating-gram-negative-bacteria-infected-wounds
#17
Ying Li, Yue Tian, Wenshu Zheng, Yan Feng, Rong Huang, Jingxin Shao, Rongbing Tang, Peng Wang, Yuexiao Jia, Jiangjiang Zhang, Wenfu Zheng, Guang Yang, Xingyu Jiang
Bacterial infections, especially multidrug-resistant bacterial infections, are an increasingly serious problem in the field of wound healing. Herein, bacterial cellulose (BC) decorated by 4,6-diamino-2-pyrimidinethiol (DAPT)-modified gold nanoparticles (Au-DAPT NPs) is presented as a dressing (BC-Au-DAPT nanocomposites) for treating bacterially infected wounds. BC-Au-DAPT nanocomposites have better efficacy (measured in terms of reduced minimum inhibition concentration) than most of the antibiotics (cefazolin/sulfamethoxazole) against Gram-negative bacteria, while maintaining excellent physicochemical properties including water uptake capability, mechanical strain, and biocompatibility...
May 23, 2017: Small
https://www.readbyqxmd.com/read/28544602/drug-residues-in-syringes-and-other-injecting-paraphernalia-in-hungary
#18
Anna Péterfi, József Csorba, Tamás Figeczki, József Kiss, Katalin Medgyesi-Frank, János Posta, V Anna Gyarmathy
The appearance and spread of new psychoactive substances (NPS) is a phenomenon detected throughout Europe since 2008. Synthetic cathinones, a group of NPS, have been self-reported as the drug injected by the vast majority of people who inject drugs (PWID) in Hungary. This study aims at updating our knowledge on what exactly the compounds injected by PWID. This multi-site study analysed residues from used injecting drug paraphernalia collected from PWID via low threshold services and from public places in Budapest, Debrecen, Miskolc, Szeged, Békéscsaba and Pécs between March 2015 and February 2016...
May 23, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28544584/examining-differences-in-characteristics-between-patients-receiving-primary-care-from-nurse-practitioners-or-physicians-using-medicare-current-beneficiary-survey-data-and-medicare-claims-data
#19
Figaro L Loresto, Daniel Jupiter, Yong-Fang Kuo
BACKGROUND: Few studies have examined differences in functional, cognitive, and psychological factors between patients utilizing only nurse practitioners (NPs) and those utilizing only primary care medical doctors (PCMDs) for primary care. PURPOSE: Patients utilizing NP-only or PCMD-only models for primary care will be characterized and compared in terms of functional, cognitive, and psychological factors. METHODOLOGY: Cohorts were obtained from the Medicare Current Beneficiary Survey linked to Medicare claims data...
May 25, 2017: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/28544560/fatal-intoxication-by-5f-adb-and-diphenidine-detection-quantification-and-investigation-of-their-main-metabolic-pathways-in-human-by-lc-ms-ms-and-lc-q-tofms
#20
Maiko Kusano, Kei Zaitsua, Kentaro Taki, Kazuaki Hisatsune, Jun'ichi Nakajima, Takako Moriyasu, Tomomi Asano, Yumi Hayashi, Hitoshi Tsuchihashi, Akira Ishii
Despite the implementation of the new blanket scheduling system in 2013, new psychoactive substance (NPS) abuse remains a serious social concern in Japan. We present a fatal intoxication case involving 5F-ADB (methyl 2-[1-(5-fluoropentyl)-1H-indazole-3-carboxamido]-3,3-dimethylbutanoate) and diphenidine. Postmortem blood screening by liquid chromatography/quadrupole time-of-flight mass spectrometry (LC/Q-TOFMS) in the information dependent acquisition (IDA) mode only detected diphenidine. Further urinary screening using an in-house database containing new NPS and metabolites detected not only diphenidine but also possible 5F-ADB metabolites; subsequent targeted screening by LC/tandem mass spectrometry (LC/MS/MS) allowed for the detection of very low level of unchanged 5F-ADB in postmortem heart blood...
May 21, 2017: Drug Testing and Analysis
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