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https://www.readbyqxmd.com/read/29903795/hepatitis-c-virus-infection-and-hospital-related-outcomes-a-systematic-review-protocol
#1
Lianping Ti, Michelle Ng, Lindila Awendila, Patrizia Maria Carrieri
INTRODUCTION: People living with hepatitis C virus (HCV) infection are disproportionately over-represented in the healthcare system due to various individual and contextual circumstances, including comorbidities and socioeconomic marginalisation. With growing trends in morbidity and mortality related to HCV infection, HCV is becoming a significant health and financial burden on the healthcare system, particularly in acute hospital settings. It is noteworthy that with the advent of direct-acting antiviral therapy the increasing number of patients who are cured of HCV could potentially result in different patterns of hospital-related outcomes over time...
June 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29877911/the-matrix-moving-from-principles-to-pragmatics-in-medical-school-curriculum-renewal
#2
Sandra Jarvis-Selinger, Maria Hubinette
Many medical programs embarking on curriculum renewal begin with overarching goals and principles, but struggle with how to translate these into an implementable curriculum and assessment practices. This article describes the Matrix, a tool developed as a means of transforming high-level pedagogic principles into a concrete curriculum while addressing the complexities of curriculum content, context, people, and places. Using a known framework as an analytic lens, the authors explore the Matrix's intended and unintended impacts on the University of British Columbia Medical Doctor Undergraduate Program (MDUP)...
June 5, 2018: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29788975/activism-and-scientific-research-20-years-of-community-action-by-the-vancouver-area-network-of-drug-users
#3
Ehsan Jozaghi, Alissa M Greer, Hugh Lampkin, Jane A Buxton
BACKGROUND: Over the past several decades, there have been numerous peer-reviewed articles written about people who use drugs (PWUDs) from the Downtown Eastside neighborhood of Vancouver, Canada. While individual researchers have engaged and acknowledged this population as participants and community partners in their work, there has been comparatively little attention given to the role of PWUDs and drug user organizations in directing, influencing, and shaping research agendas. METHODS: In this community-driven research, we examine 20 years of peer-reviewed studies, university theses, books, and reports that have been directed, influenced, and shaped by members of the activist organization the Vancouver Area Network of Drug Users (VANDU)...
May 22, 2018: Substance Abuse Treatment, Prevention, and Policy
https://www.readbyqxmd.com/read/29730752/unilateral-wrist-extension-training-after-stroke-improves-strength-and-neural-plasticity-in-both-arms
#4
Yao Sun, Noah M H Ledwell, Lara A Boyd, E Paul Zehr
Stroke induces bilateral neurological impairment and muscle weakness yielding neurologically more (MA; paretic) and less affected (LA; non-paretic) sides. "Cross-education" refers to training one side of the body to increase strength in the same muscles on the untrained side. Past work showed dorsiflexion training of the LA side produced bilateral strength increases after stroke. The current study explored the presence and extent of cross-education after arm strength training in chronic stroke. Twenty-four chronic stroke participants completed 5 weeks of maximal wrist extension training using their LA arm...
May 5, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29728690/publisher-correction-oncolytic-viruses-as-engineering-platforms-for-combination-immunotherapy
#5
Kwame Twumasi-Boateng, Jessica L Pettigrew, Y Y Eunice Kwok, John C Bell, Brad H Nelson
In the online html version of this article, the affiliations for Jessica L. Pettigrew and John C. Bell were not correct. Jessica L. Pettigrew is at the Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada and John C. Bell is at the Center for Innovative Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada. This is correct in the print and PDF versions of the article and has been corrected in the html version.
May 4, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/29726344/effectiveness-of-theta-burst-versus-high-frequency-repetitive-transcranial-magnetic-stimulation-in-patients-with-depression-three-d-a-randomised-non-inferiority-trial
#6
Daniel M Blumberger, Fidel Vila-Rodriguez, Kevin E Thorpe, Kfir Feffer, Yoshihiro Noda, Peter Giacobbe, Yuliya Knyahnytska, Sidney H Kennedy, Raymond W Lam, Zafiris J Daskalakis, Jonathan Downar
BACKGROUND: Treatment-resistant major depressive disorder is common; repetitive transcranial magnetic stimulation (rTMS) by use of high-frequency (10 Hz) left-side dorsolateral prefrontal cortex stimulation is an evidence-based treatment for this disorder. Intermittent theta burst stimulation (iTBS) is a newer form of rTMS that can be delivered in 3 min, versus 37·5 min for a standard 10 Hz treatment session. We aimed to establish the clinical effectiveness, safety, and tolerability of iTBS compared with standard 10 Hz rTMS in adults with treatment-resistant depression...
April 28, 2018: Lancet
https://www.readbyqxmd.com/read/29713317/building-a-geochemical-view-of-microbial-salt-tolerance-halophilic-adaptation-of-marinococcus-in-a-natural-magnesium-sulfate-brine
#7
Mark G Fox-Powell, Charles S Cockell
Current knowledge of life in hypersaline habitats is mostly limited to sodium and chloride-dominated environments. This narrow compositional window does not reflect the diversity of brine environments that exist naturally on Earth and other planetary bodies. Understanding the limits of the microbial biosphere and predicting extraterrestrial habitability demands a systematic effort to characterize ionic specificities of organisms from a representative range of saline habitats. Here, we investigated a strain of Marinococcus isolated from the magnesium and sulfate-dominated Basque Lakes (British Columbia, Canada)...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29674936/the-man%C3%A3%C2%BA-gradient-as-a-study-system-for-bird-pollination
#8
Mannfred Ma Boehm, Micah N Scholer, Jeremiah Jc Kennedy, Julian M Heavyside, Aniceto Daza, David Guevara-Apaza, Jill E Jankowski
Background: This study establishes an altiudinal gradient, spanning from the highland Andes (2400 m) to lowland Amazon, as a productive region for the study of bird pollination in Southeastern Peru. The 'Manú Gradient' has a rich history of ornithological research, the published data and resources from which lay the groundwork for analyses of plant-bird interactions. In this preliminary expedition we documented 44 plants exhibting aspects of the bird pollination syndrome, and made field observations of hummingbird visits at three sites spanning the Manú Gradient: 2800 m (Wayqecha), 1400 m (San Pedro), and 400 m (Pantiacolla)...
2018: Biodiversity Data Journal
https://www.readbyqxmd.com/read/29576514/toward-zero-waste-events-reducing-contamination-in-waste-streams-with-volunteer-assistance
#9
Ivana Zelenika, Tara Moreau, Jiaying Zhao
Public festivals and events generate a tremendous amount of waste, especially when they involve food and drink. To reduce contamination across waste streams, we evaluated three types of interventions at a public event. In a randomized control trial, we examined the impact of volunteer staff assistance, bin tops, and sample 3D items with bin tops, on the amount of contamination and the weight of the organics, recyclable containers, paper, and garbage bins at a public event. The event was the annual Apple Festival held at the University of British Columbia, which was attended by around 10,000 visitors...
June 2018: Waste Management
https://www.readbyqxmd.com/read/29570556/province-wide-biliary-atresia-home-screening-program-in-british-columbia-evaluation-of-first-2-years
#10
Jessica P Woolfson, Richard A Schreiber, Alison E Butler, Julie MacFarlane, Janusz Kaczorowski, Lisa Masucci, Stirling Bryan, Jean Paul Collet
BACKGROUND AND OBJECTIVES: Biliary atresia (BA), a rare newborn liver disease, is the leading cause of liver-related death in children. Early disease recognition and timely surgical Kasai hepatoportoenterostomy (KP) offers long-term survival without liver transplant. Universal BA screening in Taiwan using infant stool color cards (ISCCs) has proven effectiveness. We report our experience with infant stool color card (ISCC) BA screening in a province-wide program in British Columbia (BC)...
June 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29550783/study-protocol-for-vitality-a-proof-of-concept-randomised-controlled-trial-of-exercise-training-or-complex-mental-and-social-activities-to-promote-cognition-in-adults-with-chronic-stroke
#11
John R Best, Janice J Eng, Jennifer C Davis, Robin Hsiung, Peter A Hall, Laura E Middleton, Peter Graf, Charles H Goldsmith, Teresa Liu-Ambrose
INTRODUCTION: Cerebrovascular disease-such as stroke-is the second most common cause of dementia (ie, vascular dementia). Specifically, a stroke increases one's risk for dementia by a factor of two. Thus, stroke survivors represent a target population in need of intervention strategies to promote cognitive function and prevent dementia. The current standard of care in stroke rehabilitation does not adequately address the significant cognitive consequences of stroke, especially for those who are in the chronic phase (ie, >12 months since an index stroke)...
March 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29540458/universal-genotyping-for-tuberculosis-prevention-programs-a-5-year-comparison-with-on-request-genotyping
#12
Jennifer L Guthrie, Clare Kong, David Roth, Danielle Jorgensen, Mabel Rodrigues, Patrick Tang, Maichael Thejoe, Kevin Elwood, Victoria J Cook, James Johnston, Jennifer L Gardy
Prospective universal genotyping of tuberculosis (TB) isolates is used by many laboratories to detect clusters of cases and inform contact investigations. Prior to universal genotyping, most TB prevention programs genotyped isolates on request only, relying on requests from public health professionals whose knowledge of a patient's clinical, demographic, and epidemiological characteristics suggested potential transmission. To justify the switch from on-request to universal genotyping-particularly in the public health domain, with its limited resources and competing priorities-it is important to demonstrate the additional benefit provided by a universal genotyping program...
May 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29513211/sterilization-of-ceramic-sharpening-stones
#13
Colin B Wiebe, Bonnie J Hoath, Gethin Owen, Jiarui Bi, Georgios Giannelis, Hannu S Larjava
Traditionally, periodontal hand instruments are honed or sharpened during patient care as they dull easily during contact with enamel, calculus and cementum. This approach is taught in dental and hygiene schools around the world and remains the standard of care. Recently, some professional organizations have questioned whether this practice should be abandoned because of safety issues. Questions have been raised whether sharpening stones can be properly sterilized and whether the sharpening of contaminated instruments poses a health hazard for the provider...
September 2017: Journal—Canadian Dental Association, Journal de L'Association Dentaire Canadienne
https://www.readbyqxmd.com/read/29506739/chronic-kidney-damage-in-the-adult-fontan-population
#14
D Lee, A Levin, M Kiess, G Sexsmith, S Chakrabarti, A Barlow, D Human, J Grewal
OBJECTIVES: 1) To determine the accuracy of estimated GFR (eGFR) as compared to directly measured GFR (mGFR) in the adult Fontan population; 2) to determine the true prevalence of chronic kidney damage (CKD) as determined by uACR AND eGFR. METHODS: Prospective study of 81 patients Fontan patients (≥18years) followed at St. Paul's Hospital, University of British Columbia. CKD-EPI and MDRD equations used to calculate eGFR, mGFR determined by 99m Tc-DTPA renal dynamic imaging and urine albumin to creatinine ratios were calculated...
April 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29504442/educational-leadership-during-a-decade-of-medical-curricular-innovation-and-renewal
#15
Karen E Pinder, Jennifer A Shabbits
BACKGROUND: The past decade has witnessed successful expansion, distribution and curricular renewal at the University of British Columbia (UBC) medical school. The expansion and distribution of the medical program doubled enrollment and established the first North American medical school training students across multiple geographical locations. The more recent competency-based curriculum renewal demonstrates sustained innovation within UBC medicine. AIMS: This paper describes that a significant contributor to these successes has been a team of teaching faculty whose exclusive roles have been providing curricular support...
March 5, 2018: Medical Teacher
https://www.readbyqxmd.com/read/29455071/the-use-of-satellite-data-to-measure-ultraviolet-b-penetrance-and-its-potential-association-with-age-of-multiple-sclerosis-onset
#16
Ofer Amram, Nadine Schuurman, Ellen Randall, Feng Zhu, Jameelah Saeedi, Peter Rieckmann, Irene Yee, Helen Tremlett
BACKGROUND: Studies have indicated an association between low Ultraviolet B (UVB) exposure and an increased risk of developing multiple sclerosis (MS). Few studies, however, have explored whether UVB exposure is associated with the age at MS symptom onset. OBJECTIVE: We investigated the potential association between cumulative early life ambient UVB exposure and age at MS onset, using satellite data to measure ambient UVB exposure. METHODS: Adult onset MS patients were selected from the University of British Columbia's MS genetic database (1980-2005)...
April 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29411629/clinical-texting-among-medical-trainees-of-the-university-of-british-columbia
#17
Danny Guo, Nam Phan, Kendall Ho, John Pawlovich, Neil Kitson
We believe cellphone text messages are commonly used in medical practice whether in rural or urban settings and that clinical photos are often attached to them. Our interest is the use of this technology to provide dermatology service to rural and remote British Columbia. Concern has been expressed about the security of confidential information and adequacy of privacy protection in such an application. We have found little published information about the extent of texting in rural and remote settings (and none in our jurisdiction) or the number and nature of privacy breaches that have actually occurred as a result...
February 1, 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29410142/a-randomized-multicenter-study-assessing-the-educational-impact-of-a-computerized-interactive-hysterectomy-trainer-on-gynecology-residents
#18
Allan S Lichtman, William Parker, Barbara Goff, Neeraj Mehra, Eliane M Shore, Guylaine Lefebvre, Alexander Chiang, John Lenihan, Henk W R Schreuder
STUDY OBJECTIVE: To assess the improvement of cognitive surgical knowledge of laparoscopic hysterectomy in postgraduate year (PGY) 1 and 2 gynecology residents who used an interactive computer-based Laparoscopic Hysterectomy Trainer (Red Llama, Inc., Seattle, WA). DESIGN: A multicenter, randomized, controlled study (Canadian Task Force classification I). SETTING: Five departments of obstetrics and gynecology: Keck School of Medicine of the University of Southern California, Los Angeles, CA; University of California, Los Angeles, Los Angeles, CA; University of Washington, Seattle, WA; University of British Columbia, Vancouver, British Columbia, Canada; and University of Toronto, Toronto, Ontario, Canada...
February 2, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29394462/sex-ethnic-and-age-specific-centile-curves-for-pqct-and-hr-pqct-derived-measures-of-bone-structure-and-strength-in-adolescents-and-young-adults
#19
Leigh Gabel, Heather M Macdonald, Lindsay A Nettlefold, Heather A McKay
There are presently no adolescent centile curves for bone parameters at the tibial midshaft using peripheral quantitative computed tomography (pQCT) or at the distal radius and tibia using high-resolution pQCT (HR-pQCT). Thus, we aimed to develop sex-, ethnic-, site-, and age-specific centile curves for pQCT and HR-pQCT-derived bone outcomes for youth and young adults aged 10 to 21 years. We acquired pQCT scans (XCT3000 or XCT2000) at the tibial midshaft (50% site) and HR-pQCT scans (XtremeCT) at the distal radius (7% site) and tibia (8% site) in a convenience sample of participants in the mixed-longitudinal University of British Columbia Healthy Bones III Study...
February 2, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29373595/hospitalizations-due-to-unintentional-transport-injuries-among-aboriginal-population-of-british-columbia-canada-incidence-changes-over-time-and-ecological-analysis-of-risk-markers
#20
Mariana Brussoni, M Anne George, Andrew Jin, Ofer Amram, Rod McCormick, Christopher E Lalonde
BACKGROUND: Worldwide, Indigenous people have disproportionately higher rates of transport injuries. We examined disparities in injury-related hospitalizations resulting from transport incidents for three population groups in British Columbia (BC): total population, Aboriginal off-reserve, and Aboriginal on-reserve populations. We also examined sociodemographic, geographic and ethnic risk markers for disparities. METHODS: We identified Aboriginal people through BC's universal health care insurance plan insurance premium group and birth and death record notations...
2018: PloS One
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