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https://www.readbyqxmd.com/read/28939587/expression-and-genetic-variation-in-neuroendocrine-signaling-pathways-in-lethal-and-nonlethal-prostate-cancer-among-men-diagnosed-with-localized-disease
#1
Donghao Lu, Jessica Carlsson, Kathryn L Penney, Sabina Davidsson, Swen-Olof Andersson, Lorelei A Mucci, Unnur Valdimarsdóttir, Ove Andrén, Fang Fang, Katja Fall
BACKGROUND: Recent data suggest that neuroendocrine signaling pathways may play a role in the progression of prostate cancer, particularly for early-stage disease. We aimed to explore whether expression of selected genes in the adrenergic, serotoninergic, glucocorticoid, and dopaminergic pathways differs in prostate tumor tissue from men with lethal disease compared to men with nonlethal disease. METHODS: Based on the Swedish Watchful Waiting Cohort, we included 511 men diagnosed with incidental prostate cancer through TURP during 1977-1998 with follow-up up to 30 years...
September 22, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28935026/marginal-structural-model-to-evaluate-the-joint-effect-of-socioeconomic-exposures-on-the-risk-of-developing-end-stage-renal-disease-in-patients-with-type-1-diabetes-a-longitudinal-study-based-on-data-from-the-swedish-childhood-diabetes-study-group
#2
Laura Pazzagli, Anna Möllsten, Ingeborg Waernbaum
PURPOSE: Diabetic nephropathy is a severe complication of type 1 diabetes (T1D) that may lead to renal failure and end-stage renal disease (ESRD) demanding dialysis and transplantation. The etiology of diabetic nephropathy is multifactorial and both genes and environmental and life style-related factors are involved. In this study, we investigate the effect of the socioeconomic exposures, unemployment and receiving income support, on the development of ESRD in T1D patients, using a marginal structural model (MSM) in comparison with standard logistic regression models...
August 2017: Annals of Epidemiology
https://www.readbyqxmd.com/read/28934851/topliss-batchwise-schemes-reviewed-in-the-era-of-open-data-reveal-significant-differences-between-enzymes-and-membrane-receptors
#3
Lars Richter
In 1977, John G. Topliss introduced the Topliss Batchwise Scheme, a straightforward non-mathematical procedure to assist medicinal chemists in optimizing the substitution pattern of a phenyl ring. Despite its long period of application, a thorough validation of this method has been missing so far. Here, we address this issue by gathering 129 congeneric series from the ChEMBL database, suitable to retrospectively assess the approach. Frequency analysis of Topliss' schemes showed that the π, Es, σ and -σ scheme occurred in 17, 20, 6 and 4 congeneric series, respectively...
September 21, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28934778/the-effect-of-early-use-of-supplemental-therapy-on-preventing-postherpetic-neuralgia-a-systematic-review-and-meta-analysis
#4
Xiu-Fang Xing, Zhen-Feng Zhou, Feng-Jiang Zhang, Min Yan
BACKGROUND: Postherpetic neuralgia (PHN) is the most common and refractory complication of herpes zoster (HZ). Aggressive treatment of acute pain in HZ has the potential to prevent the development of PHN, but the preventive efficacy of supplemental therapy commonly used in clinical practice is controversial. OBJECTIVES: Our aim is to examine the efficacy of supplemental therapy in preventing PHN. STUDY DESIGN: A meta-analysis. SETTING: All of the selected studies are randomized controlled trials (RCTs)...
September 2017: Pain Physician
https://www.readbyqxmd.com/read/28932620/distinct-roles-of-catalytic-cysteine-and-histidine-in-the-protease-and-ligase-mechanisms-of-human-legumain-as-revealed-by-dft-based-qm-mm-simulations
#5
Brigitta Elsässer, Florian B Zauner, Johann Messner, Wai Tuck Soh, Elfriede Dall, Hans Brandstetter
The cysteine protease enzyme legumain hydrolyzes peptide bonds with high specificity after asparagine and under more acidic conditions after aspartic acid [Baker E. N.J. Mol. Biol.1980, 141, 441-484; Baker E. N.; J. Mol. Biol.1977, 111, 207-210; Drenth J.; Biochemistry1976, 15, 3731-3738; Menard R.; J. Cell. Biochem.1994, 137; Polgar L.Eur. J. Biochem.1978, 88, 513-521; Storer A. C.; Methods Enzymol.1994, 244, 486-500. Remarkably, legumain additionally exhibits ligase activity that prevails at pH > 5.5. The atomic reaction mechanisms including their pH dependence are only partly understood...
September 1, 2017: ACS Catalysis
https://www.readbyqxmd.com/read/28930520/molecular-evolution-of-hemagglutinin-gene-of-influenza-a-virus
#6
Antara De
In the history of human civilization, influenza is the second most catastrophic killer disease for mankind with plague ranking first in the medieval times. The 1918-1919 'Spanish flu' killed 20-50 million people worldwide. According to a report from WHO, there have been four pandemics, several epidemics and recurrent seasonal outbreaks of influenza in different parts of the world. The virus is a potential bioterrorism threat with biological 'Chernobyl-like disaster' that occurred in Soviet Russia in 1977. Here, the author reviews the biology of the surface exposed hemagglutinin of the influenza virus, a gene under constant positive selection pressure to evade host immunity and vaccination...
January 1, 2018: Frontiers in Bioscience (Scholar Edition)
https://www.readbyqxmd.com/read/28928776/analytical-methods-for-the-measurement-of-polymerization-kinetics-and-stresses-of-dental-resin-based-composites-a-review
#7
REVIEW
Mehrsima Ghavami-Lahiji, Tabassom Hooshmand
Resin-based composites are commonly used restorative materials in dentistry. Such tooth-colored restorations can adhere to the dental tissues. One drawback is that the polymerization shrinkage and induced stresses during the curing procedure is an inherent property of resin composite materials that might impair their performance. This review focuses on the significant developments of laboratory tools in the measurement of polymerization shrinkage and stresses of dental resin-based materials during polymerization...
July 2017: Dental Research Journal
https://www.readbyqxmd.com/read/28925920/low-radon-exposure-and-mortality-among-jouac-uranium-miners-an-update-of-the-french-cohort-1946-2007
#8
Estelle Rage, Sylvaine Caër-Lorho, Dominique Laurier
After the extension of the French cohort of uranium miners with the inclusion of workers employed in the Jouac mines, this article seeks to describe the new Jouac cohort and to estimate mortality risks, as well as to quantify their relation to radon exposure in this extended cohort. The Jouac cohort includes 458 miners hired by the Société des Mines de Jouac between 1957 and 2001. As there is no measurement of radon exposure before 1978 were unavailable, only the post-1977 Jouac cohort (n=314) has been included in the French cohort, creating an extended cohort of 5400 French uranium miners followed up from 1946 to 2007...
September 19, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/28918307/an-application-of-bandura-s-four-sources-of-self-efficacy-to-the-self-management-of-type-2-diabetes-in-people-with-intellectual-disability-an-inductive-and-deductive-thematic-analysis
#9
Andrew Maine, Adele Dickson, Maria Truesdale, Michael Brown
BACKGROUND: Little is known about the successful experiences and positive perceptions of people with intellectual disabilities (ID) self-managing Type 2 Diabetes (T2D). This study sought to address this gap using Bandura's (1977) 'Four Sources of Self-Efficacy' as a framework of enquiry. METHOD: Semi-structured interviews were conducted with 10 adults with ID. Interviews were recorded, transcribed verbatim and analysed using inductive and deductive thematic analysis RESULTS: Nine sub-themes were identified following analysis of the data: 1) Mastery through knowledge; 2) Mastery through tools and strategies; 3) Mastery through autonomy; 4) Influence of social setting; 5) Positive social comparisons; 6) Positive and negative self-statements; 7) Feedback from caregivers; 8) Adjustment experiences; 9) Symptom awareness...
September 14, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28912635/profile-of-justice-involved-marijuana-and-other-substance-users-demographics-health-and-health-care-family-and-justice-system-experiences
#10
REVIEW
Nikki Freeman, Justin Landwehr, Tasseli McKay, James Derzon, Anupa Bir
Substance users are more likely to have co-occurring health problems, and this pattern is intensified among those involved with the criminal justice system. Interview data for 1977 incarcerated men in 5 states from the Multi-site Family Study on Incarceration, Parenting, and Partnering that was conducted between December 2008 and August 2011 were analyzed to compare pre-incarceration substance use patterns and health outcomes between men who primarily used marijuana, primarily used alcohol, primarily used other drugs, and did not use any illicit substances during that time...
2017: Substance Abuse: Research and Treatment
https://www.readbyqxmd.com/read/28905095/growing-canopy-on-a-college-campus-understanding-urban-forest-change-through-archival-records-and-aerial-photography
#11
Lara A Roman, Jason P Fristensky, Theodore S Eisenman, Eric J Greenfield, Robert E Lundgren, Chloe E Cerwinka, David A Hewitt, Caitlin C Welsh
Many municipalities are setting ambitious tree canopy cover goals to increase the extent of their urban forests. A historical perspective on urban forest development can help cities strategize how to establish and achieve appropriate tree cover targets. To understand how long-term urban forest change occurs, we examined the history of trees on an urban college campus: the University of Pennsylvania in Philadelphia, PA. Using a mixed methods approach, including qualitative assessments of archival records (1870-2017), complemented by quantitative analysis of tree cover from aerial imagery (1970-2012), our analysis revealed drastic canopy cover increase in the late 20th and early 21st centuries along with the principle mechanisms of that change...
September 13, 2017: Environmental Management
https://www.readbyqxmd.com/read/28904846/analyzing-the-historical-development-and-transition-of-the-korean-health-care-system
#12
Sang-Yi Lee, Chul-Woung Kim, Nam-Kyu Seo, Seung Eun Lee
OBJECTIVES: Many economically advanced countries have attempted to minimize public expenditures and pursue privatization based on the principles of neo-liberalism. However, Korea has moved contrary to this global trend. This study examines why and how the Korean health care system was formed, developed, and transformed into an integrated, single-insurer, National Health Insurance (NHI) system. METHODS: We describe the transition in the Korean health care system using an analytical framework that incorporates such critical variables as government economic development strategies and the relationships among social forces, state autonomy, and state power...
August 2017: Osong Public Health and Research Perspectives
https://www.readbyqxmd.com/read/28904594/psychological-well-being-in-italian-families-an-exploratory-approach-to-the-study-of-mental-health-across-the-adult-life-span-in-the-blue-zone
#13
Paul Kenneth Hitchcott, Maria Chiara Fastame, Jessica Ferrai, Maria Pietronilla Penna
Self-reported measures of psychological well-being and depressive symptoms were examined across differently aged family members, while controlling for the impact of marital status and personal satisfaction about family and non-family relations. Twenty-one grandchildren (i.e., ages 21-36 years) were recruited with their parents (i.e., 48-66 years old) and grandparents (i.e., 75-101 years of age) in the 'blue zone' of Ogliastra, an Italian area known for the longevity of its inhabitants. Each participant was individually presented a battery of questionnaires assessing their lifestyle and several perceived mental health indices, including the Warwick-Edinburgh Mental Well-Being Scale (WEMWBS, Tennant et al...
August 2017: Europe's journal of psychology
https://www.readbyqxmd.com/read/28895017/total-pancreatectomy-with-islet-autotransplantation-for-acute-recurrent-and-chronic-pancreatitis
#14
REVIEW
Varvara A Kirchner, Ty B Dunn, Gregory J Beilman, Srinath Chinnakotla, Timothy L Pruett, Joshua J Wilhelm, Sarah J Schwarzenberg, Martin L Freeman, Melena D Bellin
PURPOSE OF REVIEW: The first total pancreatectomy and islet autotransplantation (TP-IAT) was performed for chronic pancreatitis in 1977 with the goal to ameliorate the pain and simultaneously preserve islet function. We reviewed the recent medical literature regarding indications, patient suitability, current outcomes, and challenges in TP-IAT. RECENT FINDINGS: Current indications for TP-IAT include intractable pain secondary to chronic pancreatitis (CP) or acute recurrent pancreatitis (ARP) with failed medical and endoscopic/surgical management...
September 11, 2017: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/28885104/not-threat-but-threatening-potential-causes-and-consequences-of-gay-innumeracy
#15
Donald P Haider-Markel, Mark R Joslyn
Existing literature on numeracy suggests that people are likely to perceive out-groups as larger if the group is perceived as threating. However, some studies also suggest that numeracy is a function of wishful thinking or even a lack of political knowledge. We engage the literature on numeracy of the gay and lesbian population by employing data from 1977 and 2013 surveys of American adults. We examine the factors that are associated with estimating the gay population. Next we explore how innumeracy may shape attitudes about homosexuality and gay rights...
September 8, 2017: Journal of Homosexuality
https://www.readbyqxmd.com/read/28882490/patient-rated-long-term-results-after-complete-denervation-of-the-wrist
#16
T Fuchsberger, C E Boesch, F Tonagel, T Fischborn, H E Schaller, P Gonser
The aim of this study was to examine the long-term results after the denervation of the wrist. Between 1977 and 2001, we treated 375 patients in our clinic. The mean age was 43.5 years; 81% were male and 19% female. The long-term results were assessed by a questionnaire assessing pain on a visual analog scale and patient satisfaction and by the DASH questionnaire. After a mean follow-up of 12.23 years, we found an overall pain reduction of 52.1%. In 67.7% of the patients, we found a relief of pain: of these, 44% are free of pain until today and 56% were temporarily asymptomatic...
August 16, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28880285/maryam-mirzakhani-1977-2017
#17
Kasra Rafi
No abstract text is available yet for this article.
September 6, 2017: Nature
https://www.readbyqxmd.com/read/28878778/multivariate-analysis-as-a-support-for-diagnostic-flowcharts-in-allergic-bronchopulmonary-aspergillosis-a-proof-of-concept-study
#18
Joana Vitte, Stéphane Ranque, Ania Carsin, Carine Gomez, Thomas Romain, Carole Cassagne, Marion Gouitaa, Mélisande Baravalle-Einaudi, Nathalie Stremler-Le Bel, Martine Reynaud-Gaubert, Jean-Christophe Dubus, Jean-Louis Mège, Jean Gaudart
Molecular-based allergy diagnosis yields multiple biomarker datasets. The classical diagnostic score for allergic bronchopulmonary aspergillosis (ABPA), a severe disease usually occurring in asthmatic patients and people with cystic fibrosis, comprises succinct immunological criteria formulated in 1977: total IgE, anti-Aspergillus fumigatus (Af) IgE, anti-Af "precipitins," and anti-Af IgG. Progress achieved over the last four decades led to multiple IgE and IgG(4) Af biomarkers available with quantitative, standardized, molecular-level reports...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28877949/feasibility-randomised-multicentre-double-blind-double-dummy-controlled-trial-of-anakinra-an-interleukin-1-receptor-antagonist-versus-intramuscular-methylprednisolone-for-acute-gout-attacks-in-patients-with-chronic-kidney-disease-asgard-protocol-study
#19
Gowrie Balasubramaniam, Trisha Parker, David Turner, Mike Parker, Jonathan Scales, Patrick Harnett, Michael Harrison, Khalid Ahmed, Sweta Bhagat, Thiraupathy Marianayagam, Costantino Pitzalis, Christian Mallen, Edward Roddy, Mike Almond, Bhaskar Dasgupta
INTRODUCTION: Acute gout occurs in people with chronic kidney disease, who are commonly older people with comorbidities such as hypertension, heart disease and diabetes. Potentially harmful treatments are administered to these vulnerable patients due to a lack of clear evidence. Newly available treatment that targets a key inflammatory pathway in acute gout attacks provides an opportunity to undertake the first-ever trial specifically looking treating people with kidney disease. This paper describes the protocol for a feasibility randomised controlled trial (RCT) comparing anakinra, a novel interleukin-1 antagonist versus steroids in people with chronic kidney disease (ASGARD)...
September 5, 2017: BMJ Open
https://www.readbyqxmd.com/read/28876591/the-african-surgical-outcomes-study-a-7-day-prospective-observational-cohort-study
#20
T E Madiba, B Biccard
BACKGROUND: Postoperative mortality represents a major global health burden. There is little internationally comparable data from Africa of outcomes following surgery. METHOD: Seven day, national, multicentre, prospective, observational cohort study of patients ≥18 years of age undergoing in-patient surgery in Africa. The primary outcome was in-hospital postoperative surgical complications. Secondary outcomes included; i) in-hospital mortality, ii) and the relationship between postoperative complications and postoperative mortality, and the risk factors independently associated with in-hospital mortality and postoperative complications...
September 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
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