keyword
MENU ▼
Read by QxMD icon Read
search

Bacillus anthracis

keyword
https://www.readbyqxmd.com/read/29045884/effect-of-phosphate-ion-on-the-structure-of-lumazine-synthase-an-antigen-presentation-system-from-bacillus-anthracis
#1
Yangjie Wei, Newton Wahome, Prashant Kumar, Neal Whitaker, Wendy L Picking, C Russell Middaugh
Lumazine synthase (LS) is an oligomeric enzyme involved in the biosynthesis of riboflavin in microorganisms, fungi and plants. LS has become of significant interest to biomedical science because of its critical biological role and attractive structural properties for antigen presentation in vaccines. LS derived from Bacillus anthracis (BaLS) consists of 60 identical subunits forming an icosahedron. Its crystal structure has been solved, but its dynamic conformational properties have not yet been studied. We investigated the conformation of BaLS in response to different stress conditions (e...
October 15, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29042503/erratum-for-hagan-et-al-petrobactin-is-exported-from-bacillus-anthracis-by-the-rnd-type-exporter-apex
#2
A K Hagan, A Tripathi, D Berger, D H Sherman, P C Hanna
No abstract text is available yet for this article.
October 17, 2017: MBio
https://www.readbyqxmd.com/read/29041790/a-retrospective-study-of-anthrax-on-the-ghaap-plateau-northern-cape-province-of-south-africa-with-special-reference-to-the-2007-2008-outbreaks
#3
Ayesha Hassim, Edgar H Dekker, Charles Byaruhanga, Tommy Reardon, Henriette Van Heerden
Anthrax is a zoonotic disease caused by the gram-positive, endospore-forming and soil-borne bacterium Bacillus anthracis. When in spore form, the organism can survive in dormancy in the environment for decades. It is a controlled disease of livestock and wild ungulates in South Africa. In South Africa, the two enzootic regions are the Kruger National Park and the Ghaap Plateau in the Northern Cape province. Farms on the Plateau span thousands of hectares comprising of wildlife - livestock mixed use farming...
September 28, 2017: Onderstepoort Journal of Veterinary Research
https://www.readbyqxmd.com/read/29034628/-screening-of-full-human-anthrax-lethal-factor-neutralizing-antibody-in-transgenic-mice
#4
Xiaolin Wang, Xiangyang Chi, Ju Liu, Weicen Liu, Shuling Liu, Shunfang Qiu, Zhonghua Wen, Pengfei Fan, Kun Liu, Xiaohong Song, Ling Fu, Jun Zhang, Changming Yu
Anthrax is a highly lethal infectious disease caused by the spore-forming bacterium Bacillus anthracis. The major virulence factor of B. anthracis consists of protective antigen (PA), lethal factor (LF) and edema factor (EF). PA binds with LF to form lethal toxin (LT), and PA binds with EF to form edema toxin (ET). Antibiotics is hard to work in advanced anthrax infections, because injuries and deaths of the infected are mainly caused by lethal toxin (LT). Thus, the therapeutic neutralizing antibody is the most effective treatment of anthrax...
November 25, 2016: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
https://www.readbyqxmd.com/read/29029417/anti-tumor-activity-of-anthrax-toxin-variants-that-form-a-functional-translocation-pore-by-intermolecular-complementation
#5
Shihui Liu, Qian Ma, Rasem Fattah, Thomas H Bugge, Stephen H Leppla
Anthrax lethal toxin is a typical A-B type protein toxin secreted by Bacillus anthracis. Lethal factor (LF) is the catalytic A-subunit, a metalloprotease having MEKs as targets. LF relies on the cell-binding B-subunit, protective antigen (PA), to gain entry into the cytosol of target cells. PA binds to cell surface toxin receptors and is activated by furin protease to form an LF-binding-competent oligomer-PA pre-pore, which converts to a functional protein-conductive pore in the acidic endocytic vesicles, allowing translocation of LF into the cytosol...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29021156/safety-and-accuracy-of-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry-maldi-tof-ms-to-identify-highly-pathogenic-organisms
#6
James T Rudrik, Marty K Soehnlen, Michael J Perry, Maureen Sullivan, Wanda Reiter-Kintz, Philip A Lee, Denise Pettit, Anthony Tran, Erin Swaney
Matrix-assisted laser desorption ionization -- time of flight mass spectrometry (MALDI-TOF MS) sample preparation methods including the direct, on-plate formic acid, and ethanol/formic acid tube extraction were evaluated for their ability to render highly pathogenic organisms non-viable and safe for handling in a Biosafety Level-2 laboratory. Of these, the tube extraction procedure was the most successful, with none of the tested strains surviving this sample preparation method. Tube extracts from several agents of bioterrorism and their near neighbors were analyzed in an eight laboratory study to examine the utility of the Bruker Biotyper and Vitek MS MALDI-TOF MS systems and their IVD, research use only, and Security-Relevant databases, as applicable, to accurately identify these agents...
October 11, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28991912/the-cody-dependent-clhab2-operon-is-involved-in-cell-shape-chaining-and-autolysis-in-bacillus-cereus-atcc-14579
#7
Eugénie Huillet, Ludovic Bridoux, Pagakrong Wanapaisan, Agnès Rejasse, Qi Peng, Watanalai Panbangred, Didier Lereclus
The Gram-positive pathogen Bacillus cereus is able to grow in chains of rod-shaped cells, but the regulation of chaining remains largely unknown. Here, we observe that glucose-grown cells of B. cereus ATCC 14579 form longer chains than those grown in the absence of glucose during the late exponential and transition growth phases, and identify that the clhAB2 operon is required for this chain lengthening phenotype. The clhAB2 operon is specific to the B. cereus group (i.e., B. thuringiensis, B. anthracis and B...
2017: PloS One
https://www.readbyqxmd.com/read/28982993/high-quality-genome-sequence-of-bacillus-anthracis-strain-14ra5914-isolated-during-an-outbreak-in-germany-in-2014
#8
Mandy C Elschner, Anne Busch, Annette Schliephake, Wolfgang Gaede, Eric Zuchantke, Herbert Tomaso
Bacillus anthracis is a zoonotic agent causing anthrax, a notifiable disease in animals. The last anthrax outbreak among cattle in Germany occurred in April 2014 in Saxony-Anhalt. Here we report a high-quality genome sequence of the Bacillus anthracis strain 14RA5914 Dobichau isolated from the spleen of a dead cow.
October 5, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28981257/bacillus-anthracis-prolyl-4-hydroxylase-interacts-with-and-modifies-elongation-factor-tu
#9
Nicholas J Schnicker, Mortezaali Razzaghi, Sanjukta Guha Thakurta, Srinivas Chakravarthy, Mishtu Dey
Prolyl hydroxylation is a very common post-translational modification and plays many roles in eukaryotes such as collagen stabilization, hypoxia sensing, and controlling protein transcription and translation. There is a growing body of evidence that suggests that prokaryotes contain prolyl 4-hydroxylases (P4Hs) homologous to the hypoxia-inducible factor (HIF) prolyl hydroxylase domain (PHD) enzymes that act on elongation factor Tu (EFTu) and are likely involved in the regulation of bacterial translation. Recent biochemical and structural studies with a PHD from Pseudomonas putida (PPHD) determined that it forms a complex with EFTu and hydroxylates a prolyl residue of EFTu...
October 19, 2017: Biochemistry
https://www.readbyqxmd.com/read/28979006/anthrax-where-margins-are-merging-between-emerging-threats-and-bioterrorism
#10
Dibyendu Banerjee, Baishali Chakraborty, Banya Chakraborty
National Institute of Allergy and Infectious Diseases has classified all the emerging infectious diseases agents under three categories. Among Category A priority pathogens comes Bacillus anthracis -the causative agent of Anthrax. It is a gram positive spore bearing bacteria, and the disease is typically associated with grazing animals, and affects the people as a zoonosis. The disease can be classically transmitted by three routes namely: cutaneous, gastrointestinal and pulmonary, with a fourth route recently identified as "injection anthrax", seen in intravenous drug abusers...
September 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28970226/the-potentiating-effect-of-mandelate-and-lactate-on-chemically-induced-germination-in-members-of-bacillus-cereus-sensu-lato
#11
Alistair H Bishop
Endospores of the genus Bacillus can be triggered to germinate by a limited number of chemicals. Mandelate had a powerful, additive effect on the level and rate of germination produced in non-heat shocked spores of Bacillus anthracis Sterne, Bacillus cereus and Bacillus thuringiensis when combined with L-alanine and inosine. Mandelate had no germinant effect on its own but was active with these germinants in a dose-dependent manner at concentrations above 0.5 mM. The maximum rate and extent of germination was produced in B...
September 29, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28968672/gastric-ph-and-toxin-factors-modulate-infectivity-and-disease-progression-following-gastrointestinal-exposure-to-bacillus-anthracis
#12
Tao Xie, David Rotstein, Chen Sun, Hui Fang, David M Frucht
Gastrointestinal (GI) anthrax is the most prevalent form of naturally acquired B. anthracis infection, associated with exposure to vegetative bacteria in infected meat (carnivores) or to fermented rumen contents (herbivores). We assessed whether key host and pathogen factors modulate infectivity and progression of infection using a mouse model of GI infection. Gastric acid neutralization increases infectivity, but 30-40% of mice succumb to infection without neutralization. Mice either fed or fasted prior to exposure show similar infectivity rates...
September 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28950879/temporal-dynamics-in-microbial-soil-communities-at-anthrax-carcass-sites
#13
Karoline Valseth, Camilla L Nesbø, W Ryan Easterday, Wendy C Turner, Jaran S Olsen, Nils Chr Stenseth, Thomas H A Haverkamp
BACKGROUND: Anthrax is a globally distributed disease affecting primarily herbivorous mammals. It is caused by the soil-dwelling and spore-forming bacterium Bacillus anthracis. The dormant B. anthracis spores become vegetative after ingestion by grazing mammals. After killing the host, B. anthracis cells return to the soil where they sporulate, completing the lifecycle of the bacterium. Here we present the first study describing temporal microbial soil community changes in Etosha National Park, Namibia, after decomposition of two plains zebra (Equus quagga) anthrax carcasses...
September 26, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28945820/anthrax-edema-toxin-disrupts-distinct-steps-in-rab11-dependent-junctional-transport
#14
Annabel Guichard, Prashant Jain, Mahtab Moayeri, Ruth Schwartz, Stephen Chin, Lin Zhu, Beatriz Cruz-Moreno, Janet Z Liu, Bernice Aguilar, Andrew Hollands, Stephen H Leppla, Victor Nizet, Ethan Bier
Various bacterial toxins circumvent host defenses through overproduction of cAMP. In a previous study, we showed that edema factor (EF), an adenylate cyclase from Bacillus anthracis, disrupts endocytic recycling mediated by the small GTPase Rab11. As a result, cargo proteins such as cadherins fail to reach inter-cellular junctions. In the present study, we provide further mechanistic dissection of Rab11 inhibition by EF using a combination of Drosophila and mammalian systems. EF blocks Rab11 trafficking after the GTP-loading step, preventing a constitutively active form of Rab11 from delivering cargo vesicles to the plasma membrane...
September 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28935372/structural-insights-into-the-dimer-tetramer-transition-of-fabi-from-bacillus-anthracis
#15
Hyun Tae Kim, Sulhee Kim, Byeong Kwan Na, Jiwoung Chung, Eunha Hwang, Kwang Yeon Hwang
Enoyl-ACP reductase (ENR, also known as FabI) has received considerable interest as an anti-bacterial target due to its essentiality in fatty acid synthesis. All the FabI structures reported to date, regardless of the organism, are composed of homo-tetramers, except for two structures: Bacillus cereus and Staphylococcus aureus FabI (bcFabI and saFabI, respectively), which have been reported as dimers. However, the reason for the existence of the dimeric form in these organisms and the biological meaning of dimeric and tetrameric forms of FabI are ambiguous...
November 4, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28934496/activities-of-gyrase-and-topoisomerase-iv-on-positively-supercoiled-dna
#16
Rachel E Ashley, Andrew Dittmore, Sylvia A McPherson, Charles L Turnbough, Keir C Neuman, Neil Osheroff
Although bacterial gyrase and topoisomerase IV have critical interactions with positively supercoiled DNA, little is known about the actions of these enzymes on overwound substrates. Therefore, the abilities of Bacillus anthracis and Escherichia coli gyrase and topoisomerase IV to relax and cleave positively supercoiled DNA were analyzed. Gyrase removed positive supercoils ∼10-fold more rapidly and more processively than it introduced negative supercoils into relaxed DNA. In time-resolved single-molecule measurements, gyrase relaxed overwound DNA with burst rates of ∼100 supercoils per second (average burst size was 6...
September 19, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28934219/low-antibody-prevalence-against-bacillus-cereus-biovar-anthracis-in-ta%C3%A3-national-park-c%C3%A3-te-d-ivoire-indicates-high-rate-of-lethal-infections-in-wildlife
#17
Fee Zimmermann, Susanne M Köhler, Kathrin Nowak, Susann Dupke, Anne Barduhn, Ariane Düx, Alexander Lang, Hélène M De Nys, Jan F Gogarten, Roland Grunow, Emmanuel Couacy-Hymann, Roman M Wittig, Silke R Klee, Fabian H Leendertz
Bacillus cereus biovar anthracis (Bcbva) is a member of the B. cereus group which carries both B. anthracis virulence plasmids, causes anthrax-like disease in various wildlife species and was described in several sub-Saharan African rainforests. Long-term monitoring of carcasses in Taï National Park, Côte d'Ivoire, revealed continuous wildlife mortality due to Bcbva in a broad range of mammalian species. While non-lethal anthrax infections in wildlife have been described for B. anthracis, nothing is known about the odds of survival following an anthrax infection caused by Bcbva...
September 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28921884/structural-characterization-and-functional-analysis-of-cystathionine-%C3%AE-synthase-an-enzyme-involved-in-the-reverse-transsulfuration-pathway-of-bacillus-anthracis
#18
Suneeta Devi, Syed Arif Abdul Rehman, Khaja Faisal Tarique, Samudrala Gourinath
The reverse transsulfuration pathway has been reported to produce cysteine from homocysteine in eukaryotes ranging from protozoans to mammals while bacteria and plants produce cysteine via a de-novo pathway. Interestingly, the bacterium Bacillus anthracis includes enzymes of the reverse transsulfuration pathway viz. cystathionine β-synthase (BaCBS, previously annotated to be an O-acetylserine sulfhydrylase (OASS)) and cystathionine γ-lyase. Here, we report the structure of BaCBS at a resolution of 2.2 Å...
September 16, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28900020/petrobactin-is-exported-from-bacillus-anthracis-by-the-rnd-type-exporter-apex
#19
A K Hagan, A Tripathi, D Berger, D H Sherman, P C Hanna
Bacillus anthracis-a Gram-positive, spore-forming bacterium-causes anthrax, a highly lethal disease with high bacteremia titers. Such rapid growth requires ample access to nutrients, including iron. However, access to this critical metal is heavily restricted in mammals, which requires B. anthracis to employ petrobactin, an iron-scavenging small molecule known as a siderophore. Petrobactin biosynthesis is mediated by asb gene products, and import of the iron-bound (holo)-siderophore into the bacterium has been well studied...
September 12, 2017: MBio
https://www.readbyqxmd.com/read/28893904/anthrax-lethal-toxin-rapidly-reduces-c-jun-levels-by-inhibiting-c-jun-gene-transcription-and-promoting-c-jun-protein-degradation
#20
Weiming Ouyang, Pengfei Guo, Hui Fang, David M Frucht
Anthrax is a life threatening disease caused by infection with Bacillus anthracis, which expresses lethal factor and the receptor-binding protective antigen. These two proteins combine to form anthrax lethal toxin (LT), whose proximal targets are mitogen activated kinase kinases (MKKs). However, the downstream mediators of LT toxicity remain elusive. We herein report that LT exposure rapidly reduces the levels of cJun, a key regulator of cell proliferation and survival. Blockade of proteasome dependent protein degradation with the 26S proteasome inhibitor MG132 largely restored cJun protein levels, suggesting that LT promotes degradation of cJun protein...
September 11, 2017: Journal of Biological Chemistry
keyword
keyword
84384
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"