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https://www.readbyqxmd.com/read/27722362/molecular-mechanisms-of-the-anti-obesity-effect-of-bioactive-compounds-in-tea-and-coffee
#1
Min-Hsiung Pan, Yen-Chen Tung, Guliang Yang, Shiming Li, Chi-Tang Ho
Obesity is a serious health problem in adults and children worldwide. However, the basic strategies for the management of obesity (diet, exercise, drugs and surgery) have limitations and side effects. Therefore, many researchers have sought to identify bioactive components in food. Tea and coffee are the most frequently consumed beverages in the whole world. Their health benefits have been studied for decades, especially those of green tea. The anti-obesity effect of tea and coffee has been studied for at least ten years...
October 10, 2016: Food & Function
https://www.readbyqxmd.com/read/27609670/effects-of-ilex-paraguariensis-yerba-mate-on-the-hypothalamic-signalling-of-insulin-and-leptin-and-liver-dysfunction-in-adult-rats-overfed-during-lactation
#2
E P S Conceição, A R Kaezer, N Peixoto-Silva, I Felzenszwalb, E de Oliveira, E G Moura, P C Lisboa
Ilex paraguariensis (yerba mate) has a beneficial effect in the management of obesity. Here, we studied the effects of yerba mate on hypothalamic changes in leptin and insulin signalling, oxidative stress and liver morphology and metabolism in postnatal early overfeeding (EO) Wistar rats. To induce EO, the litter size was reduced to three pups per dam, and litters with 10 pups per dam were used as a control (10 litters each). On postnatal day (PN) 150, EO offspring were subdivided into EO and EO+mate groups (10 animals each), which were treated with water or mate tea [1 g/kg body weight (BW)/day, by gavage], respectively, for 30 days...
September 9, 2016: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/27271251/oxidized-tea-polyphenols-prevent-lipid-accumulation-in-liver-and-visceral-white-adipose-tissue-in-rats
#3
Sumin Wang, Yewei Huang, Huanhuan Xu, Qiangqiang Zhu, Hao Lu, Mengmeng Zhang, Shumei Hao, Chongye Fang, Dongying Zhang, Xiaoyun Wu, Xuanjun Wang, Jun Sheng
BACKGROUND: Tea polyphenols are the prominent component in tea. After the fermentation process, tea polyphenols are oxidized by polyphenol oxidase to form oxidized tea polyphenols (OTPs). OTPs contain a significant amount of hydrophobic phenyl groups that can bind with non-aqueous materials. Here, we determined whether OTPs can bind with lipids and reduce fat uptake and assessed the effect of OTPs on decreasing obesity and alleviating hyperlipidaemia and other metabolic syndromes. METHODS: Rats were divided into three groups: control, high-fat diet (HFD) and OTP groups...
June 7, 2016: European Journal of Nutrition
https://www.readbyqxmd.com/read/27237789/theaflavin-synthesized-in-a-selective-domino-type-one-pot-enzymatic-biotransformation-method-with-camellia-sinensis-cell-culture-inhibits-weight-gain-and-fat-accumulation-to-high-fat-diet-induced-obese-mice
#4
Masumi Takemoto, Hiroaki Takemoto, Ryoyasu Saijo
The polyphenolic compound theaflavin, which is the main red pigment present in black tea, is reported to elicit various physiological effects. Because of the extremely low concentration of theaflavin present in black tea, its extraction from black tea leaves in quantities sufficient for use in medical studies has been difficult. We have developed a simple, inexpensive, selective, domino-type, one-pot enzymatic biotransformation method for the synthesis of theaflavin that is suitable for use in medical studies...
August 1, 2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27161951/black-tea-polyphenols-and-polysaccharides-improve-body-composition-increase-fecal-fatty-acid-and-regulate-fat-metabolism-in-high-fat-diet-induced-obese-rats
#5
Tao Wu, Yu Guo, Rui Liu, Kuan Wang, Min Zhang
With the current changes in diet and living habits, obesity has become a global health problem. Thus, the weight-reducing function of tea has attracted considerable attention. This study investigated the anti-obesity effect and the mechanism of black tea (BT) polyphenols and polysaccharides in male Sprague-Dawley rats. The BT polyphenols and polysaccharides reduced the body weight, Lee's index, visceral fat weight, and fat cell size but improved the biochemical profile and increased the fecal fatty acid content, thereby preventing high-fat diet-induced obesity...
May 18, 2016: Food & Function
https://www.readbyqxmd.com/read/26582155/anthocyanin-rich-phytochemicals-from-aronia-fruits-inhibit-visceral-fat-accumulation-and-hyperglycemia-in-high-fat-diet-induced-dietary-obese-rats
#6
Azusa Takahashi, Hisae Shimizu, Yukako Okazaki, Hirohide Sakaguchi, Toshio Taira, Takashi Suzuki, Hideyuki Chiji
Aronia fruits (chokeberry: Aronia melanocarpa E.) containing phenolic phytochemicals, such as cyanidin 3-glycosides and chlorogenic acid, have attracted considerable attention because of their potential human health benefits in humans including antioxidant activities and ability to improved vision. In the present study, the effects of anthocyanin-rich phytochemicals from aronia fruits (aronia phytochemicals) on visceral fat accumulation and fasting hyperglycemia were examined in rats fed a high-fat diet (Experiment 1)...
2015: Journal of Oleo Science
https://www.readbyqxmd.com/read/26569165/green-tea-beverages-enriched-with-catechins-with-a-galloyl-moiety-reduce-body-fat-in-moderately-obese-adults-a-randomized-double-blind-placebo-controlled-trial
#7
RANDOMIZED CONTROLLED TRIAL
Makoto Kobayashi, Takanori Kawano, Yuuichi Ukawa, Yuko M Sagesaka, Ikuo Fukuhara
Objective To determine whether ingesting a green tea beverage enriched with catechins with a galloyl moiety during a meal reduces body fat in moderately obese adults. Design Randomized double-blind placebo-controlled study. Subjects A total of 126 obese subjects (25 ≤ body mass index < 30 kg m(-2)) were randomly assigned to a group receiving green tea beverages without catechins (placebo), or a group receiving green tea beverages with a low or high content of catechins with a galloyl moiety. Each subject ingested 500 mL bottled green tea beverages containing 25, 180, or 279...
January 2016: Food & Function
https://www.readbyqxmd.com/read/26203820/cyclocarya-paliurus-prevents-high-fat-diet-induced-hyperlipidemia-and-obesity-in-sprague-dawley-rats
#8
Xiaoming Yao, Zi Lin, Cuihua Jiang, Meng Gao, Qingqing Wang, Nan Yao, Yonglan Ma, Yue Li, Shengzuo Fang, Xulan Shang, Yicheng Ni, Jian Zhang, Zhiqi Yin
Cyclocarya paliurus (CP; qing qian liu), which is used as an herbal tea in China, has been confirmed to have therapeutic effects on hyperlipidemia and obesity, and therefore it is widely consumed to prevent metabolic diseases such as hyperlipidemia and diabetes. In this study, we investigated the preventive effects of CP on obesity and hyperlipidemia, as well as the underlying mechanisms involved in intestinal secretion of apolipoprotein (apo) B48. Sprague-Dawley rats were fed a high-fat diet (HFD) and with or without various concentrations of an ethanol extract of CP (CPE; 2, 4, or 8 g·(kg body mass)(-1)) administered by gavage for 8 weeks...
August 2015: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/25844091/decaffeinated-green-tea-and-voluntary-exercise-induce-gene-changes-related-to-beige-adipocyte-formation-in-high-fat-fed-obese-mice
#9
Sudathip Sae-Tan, Connie J Rogers, Joshua D Lambert
We have previously reported that decaffeinated green tea extract (GTE) in combination with voluntary exercise (Ex) reduces metabolic syndrome in high fat-fed C57BL/6J mice. Here, we examined for the first time the effect of treatment with 77 mg/g GTE, Ex, or both (GTE + Ex) on genes related to the conversion of white adipose tissue (WAT) to brown fat-like adipose tissue (BLAT) in this model. GTE+Ex induced genes related to lipolysis (hormone sensitive lipase [3.0-fold] and patatin-like phospholipase domain-containing protein 2 [2-fold]), mitochondrial β-oxidation (NADH dehydrogenase 5 [2...
April 1, 2015: Journal of Functional Foods
https://www.readbyqxmd.com/read/25791371/how-effective-are-antioxidant-supplements-in-obesity-and-diabetes
#10
REVIEW
Daniyal Abdali, Sue E Samson, Ashok Kumar Grover
Obesity is a central health issue due to its epidemic prevalence and its association with type 2 diabetes and other comorbidities. Obesity is not just being overweight. It is a metabolic disorder due to the accumulation of excess dietary calories into visceral fat and the release of high concentrations of free fatty acids into various organs. It represents a state of chronic oxidative stress and low-grade inflammation whose intermediary molecules may include leptin, adiponectin and cytokines. It may progress to hyperglycemia, leading to type 2 diabetes...
2015: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/25785691/body-fat-accumulation-in-zebrafish-is-induced-by-a-diet-rich-in-fat-and-reduced-by-supplementation-with-green-tea-extract
#11
Shinichi Meguro, Takahiro Hasumura, Tadashi Hase
Fat-rich diets not only induce obesity in humans but also make animals obese. Therefore, animals that accumulate body fat in response to a high-fat diet (especially rodents) are commonly used in obesity research. The effect of dietary fat on body fat accumulation is not fully understood in zebrafish, an excellent model of vertebrate lipid metabolism. Here, we explored the effects of dietary fat and green tea extract, which has anti-obesity properties, on body fat accumulation in zebrafish. Adult zebrafish were allocated to four diet groups and over 6 weeks were fed a high-fat diet containing basal diet plus two types of fat or a low-fat diet containing basal diet plus carbohydrate or protein...
2015: PloS One
https://www.readbyqxmd.com/read/25774551/activation-of-transient-receptor-potential-vanilloid-3-channel-suppresses-adipogenesis
#12
Sin Ying Cheung, Yu Huang, Hiu Yee Kwan, Hau Yin Chung, Xiaoqiang Yao
The present study shows that activation of the transient receptor potential vanilloid 3 channel (TRPV3) suppresses adipocyte differentiation. We also found that a major functional catechin compound in green tea and cocoa, (-)-epicatechin, exerts antiadipogenic effects in the adipocytes through direct activation of TRPV3. TRPV3 was detected in the 3T3-L1 adipocytes using immunohistochemistry and semiquantitative PCR. TRPV3 activation by activators (-)-epicatechin and diphenylborinic anhydride was determined using live cell fluorescent Ca(2+) imaging and patch-clamp electrophysiology...
June 2015: Endocrinology
https://www.readbyqxmd.com/read/25098399/oolong-black-and-pu-erh-tea-suppresses-adiposity-in-mice-via-activation-of-amp-activated-protein-kinase
#13
Yoko Yamashita, Liuqing Wang, Lihua Wang, Yuki Tanaka, Tianshun Zhang, Hitoshi Ashida
It is well known that tea has a variety of beneficial impacts on human health, including anti-obesity effects. It is well documented that green tea and its constituent catechins suppress obesity, but the effects of other types of tea on obesity and the potential mechanisms involved are not yet fully understood. In this study, we investigated the suppression of adiposity by oolong, black and pu-erh tea and characterized the underlying molecular mechanism in vivo. We found that the consumption of oolong, black or pu-erh tea for a period of one week significantly decreased visceral fat without affecting body weight in male ICR mice...
October 2014: Food & Function
https://www.readbyqxmd.com/read/25031332/green-tea-black-tea-and-oolong-tea-polyphenols-reduce-visceral-fat-and-inflammation-in-mice-fed-high-fat-high-sucrose-obesogenic-diets
#14
David Heber, Yanjun Zhang, Jieping Yang, Janice E Ma, Susanne M Henning, Zhaoping Li
Green tea (GT) and caffeine in combination were shown to increase energy expenditure and fat oxidation, but less is known about the effects of black tea (BT) and oolong tea (OT). This study investigated whether decaffeinated polyphenol extracts from GT, BT, and OT decrease body fat and inflammation in male C57BL/6J mice fed high-fat/high-sucrose [HF/HS (32% energy from fat, 25% energy from sucrose)] diets. Mice were fed either an HF/HS diet with 0.25% of polyphenol from GT, OT, or BT or a low-fat/high-sucrose [LF/HS (10...
September 2014: Journal of Nutrition
https://www.readbyqxmd.com/read/24842709/pomegranate-and-green-tea-extracts-protect-against-er-stress-induced-by-a-high-fat-diet-in-skeletal-muscle-of-mice
#15
Julie Rodriguez, Hélène Gilson, Cécile Jamart, Damien Naslain, Nicolas Pierre, Louise Deldicque, Marc Francaux
PURPOSE: We tested the hypothesis that polyphenol-rich extracts can reduce endoplasmic reticulum (ER) stress induced by a high-fat diet (HFD) in skeletal muscle of mice. METHODS: Mice were randomly assigned to four groups receiving during 20 weeks either a standard chow control (CTRL), or a HFD supplemented, or not, with pomegranate (HFD + P) or green tea (HFD + GT) extracts. After the nutritional intervention, mice were killed and gastrocnemius muscles were taken...
April 2015: European Journal of Nutrition
https://www.readbyqxmd.com/read/24375945/voluntary-exercise-and-green-tea-enhance-the-expression-of-genes-related-to-energy-utilization-and-attenuate-metabolic-syndrome-in-high-fat-fed-mice
#16
Sudathip Sae-Tan, Connie J Rogers, Joshua D Lambert
Obesity and metabolic syndrome are growing public health problems. We investigated the effects of decaffeinated green tea extract (GTE) and voluntary running exercise (Ex) alone or in combination against obesity and metabolic syndrome in high fat (HF) fed C57BL/6J mice. After 16 wk, GTE + Ex treatment reduced final body mass (27.1% decrease) and total visceral fat mass (36.6% decrease) compared to HF-fed mice. GTE + Ex reduced fasting blood glucose (17% decrease), plasma insulin (65% decrease), and insulin resistance (65% decrease) compared to HF-fed mice...
May 2014: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/24251710/role-of-diet-and-nutritional-management-in-non-alcoholic-fatty-liver-disease
#17
Jian-Gao Fan, Hai-Xia Cao
Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum ranging from simple steatosis to non-alcoholic steatohepatitis, which causes an increased risk of cirrhosis, type 2 diabetes, and cardiovascular complications. With the worldwide growing incidence of obesity, sedentary lifestyle, and unhealthy dietary pattern, NAFLD has currently been recognized as a major health burden. Dietary patterns and nutrients are the important contributors to the development, progression, and treatment of NAFLD and associated metabolic comorbidities...
December 2013: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/23864528/green-tea-catechins-prevent-obesity-through-modulation-of-peroxisome-proliferator-activated-receptors
#18
Jingqi Yan, Yan Zhao, Baolu Zhao
Epidemiological evidence and experimental studies suggest that drinking green tea is associated with a lower risk of obesity and related diseases. However, the mechanisms of these effects are not clear. In the present study, we investigated the anti-obesity mechanisms of green tea catechins (GTCs) through modulation of peroxisome proliferator activated-receptor (PPAR) pathways in high-fat diet-induced obesity in rats. GTC supplementation significantly attenuated the increased body and liver weights and the elevated serum and liver triglyceride levels...
September 2013: Science China. Life Sciences
https://www.readbyqxmd.com/read/23497878/the-influence-of-goishi-tea-on-adipocytokines-in-obese-mice
#19
Junko Yokota, Kohei Jobu, Saburo Yoshioka, Takehiro Kashiwagi, Tomoko Shimamura, Hironori Moriyama, Shuzo Murata, Masao Ohishi, Hiroyuki Ukeda, Mitsuhiko Miyamura
This study investigated the influence of Goishi-tea on visceral fat weight in induced obese mice. Mice were divided into two main groups, normal and obesity. In obesity group, mice were fed with high-fat diet. Goishi-tea including its fractions (ethyl-acetate layer and water layer) was administrated in normal and obesity three sub-groups. Results showed no influence of Goishi-tea in normal group. However, visceral fat weight, size of adipose cell and cholesterol level were significantly decreased in obesity group fed Goishi-tea compared to control group...
June 15, 2013: Food Chemistry
https://www.readbyqxmd.com/read/23419401/improvement-effect-of-resistant-maltodextrin-in-humans-with-metabolic-syndrome-by-continuous-administration
#20
RANDOMIZED CONTROLLED TRIAL
Chieko Hashizume, Yuka Kishimoto, Sumiko Kanahori, Takushi Yamamoto, Kazuhiro Okuma, Kunio Yamamoto
Resistant maltodextrin (RMD) is a soluble dietary fiber ingredient whose physiological functions are well recognized in Foods for Specified Health Use (FOSHU) for maintaining healthy intestinal regularity, blood glucose levels, and serum lipids. However, its efficacy on combined health risks--metabolic syndrome--was not studied yet. In this study the efficacy of RMD on humans with metabolic syndrome was investigated. A randomized double-blind placebo-controlled parallel-group trial was conducted. Thirty subjects with metabolic syndrome were randomly allocated into 2 groups and took either tea containing 9 g of RMD (treatment group) or placebo tea at three mealtimes daily for 12 wk...
2012: Journal of Nutritional Science and Vitaminology
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