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https://www.readbyqxmd.com/read/28650001/brodalumab-the-first-anti-il-17-receptor-agent-for-psoriasis
#1
L Puig
Psoriasis is a chronic immune-mediated inflammatory skin disease in which the alteration of the interleukin-23 (IL-23)/IL-17 cytokine axis appears to be crucial from a pathogenetic perspective. This has been confirmed by the efficacy of monoclonal antibodies blocking IL-17A, such as secukinumab and ixekizumab. Brodalumab is a human anti-IL-17 receptor A (IL-17RA) monoclonal antibody that inhibits the biological activity of IL-17A, IL-17F and other IL-17 isoforms, and has been approved (210 mg s.c. at weeks 0, 1, 2 and every 2 weeks thereafter) for the treatment of psoriasis vulgaris, psoriatic arthritis, pustular psoriasis and psoriatic erythroderma in Japan (Lumicef)...
May 2017: Drugs of Today
https://www.readbyqxmd.com/read/28649751/long-term-management-of-chronic-spontaneous-urticaria-with-omalizumab
#2
M Pinto Gouveia, A Gameiro, A Pinho, M Gonçalo
BACKGROUND: Clinical trials have shown the efficacy of omalizumabs efficacy in refractory chronic spontaneous urticaria (CSU) and chronic inducible urticaria (CIndU), but real-life management strategies are lacking. AIM: To assess the long-term efficacy and safety of omalizumab, and to identify predictive factors and optimum dosage regimens. METHODS: This was a prospective study of 13 patients (11 women, 2 men) with severe CSU [weekly urticaria activity score (UAS7) > 28] resistant to anti-H1 antihistamines...
June 25, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28648908/intraventricular-cavernomas-of-the-third-ventricle-report-of-two-cases-and-a-systematic-review-of-the-literature
#3
Vivek B Beechar, Visish M Srinivasan, Oleg E Reznik, Anish Sen, Tiemo J Klisch, Alexander E Ropper, Jacob J Mandel, Kent A Heck, Timothy J Seipel, Akash J Patel
BACKGROUND: Intraventricular cavernous malformations (IVCMs) are relatively rare benign vascular malformations. Patients may be asymptomatic or present with symptoms including headache, seizure, hemorrhage, and neurological deficits. We report two cases of patients with cavernomas in the third ventricle and at the foramen of Monro (FoM) and a systematic review of the literature to examine the clinical features and the efficacy of the current standard of care for these lesions. METHODS: A systematic review was performed according to PRISMA guidelines...
June 22, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28645951/effects-of-socioeconomic-factors-on-cardiovascular-related-symptoms-among-residents-in-fukushima-after-the-great-east-japan-earthquake-a-cross-sectional-study-using-data-from-the-fukushima-health-management-survey
#4
Wen Zhang, Tetsuya Ohira, Seiji Yasumura, Masaharu Maeda, Akira Otsuru, Mayumi Harigane, Naoko Horikoshi, Yuriko Suzuki, Hirooki Yabe, Masato Nagai, Hironori Nakano, Mayumi Hirosaki, Mayu Uemura, Hideto Takahashi, Kenji Kamiya, Shunichi Yamashita, Masafumi Abe
OBJECTIVE: To investigate the association between socioeconomic factors and the exacerbation of cardiovascular symptoms among evacuees after the Great East Japan Earthquake. METHODS: A sample of 73 433 individuals was included in the Fukushima Health Management Survey. Self-report questionnaires were used to determine the influence of socioeconomic factors including living arrangements, loss of employment and decreased income on the exacerbation of headache, dizziness, palpitations and shortness of breath...
June 23, 2017: BMJ Open
https://www.readbyqxmd.com/read/28644963/self-report-and-subjective-history-in-the-diagnosis-of-painful-neck-conditions-a-systematic-review-of-diagnostic-accuracy-studies
#5
REVIEW
Adam Mizer, Alexa Bachmann, Jessie Gibson, Megan Burrowbridge Donaldson
Rising healthcare costs and inherent risks with over-utilizing diagnostic imaging require a quality subjective examination to improve effectiveness and time management of physical examinations. This systematic review investigates the diagnostic accuracy of subjective history and self-report items to determine if there is significant alteration in the probability of identifying specific painful neck conditions. Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. INCLUSION CRITERIA: 1) Written in the English language 2) Cervical pain with/without referred upper extremity or head pain 3) Subjective history or self-report items 4) Study designs that reported diagnostic statistics or allowed calculation of sensitivities, specificities, diagnostic odds ratios, and likelihood ratios 5) used a reference standard that has a sensitivity or specificity ≥75% or a diagnostic tool that is strongly supported in the literature where this data is not available...
June 8, 2017: Musculoskeletal Science & Practice
https://www.readbyqxmd.com/read/28643722/endogenous-endophthalmitis-caused-by-cryptococcus-neoformans-var-gattii-mimicking-choroidal-tumor-from-positron-emission-tomography-computed-tomography-to-histopathology
#6
Chun-Ju Lin, Wen-Lu Chen, Jane-Ming Lin, Peng-Tai Tien, Yi-Yu Tsai
A 60-year-old immunocompetent female with pneumonia history about 10 years ago suffered from blurred vision overall survival for 3 weeks. Common cold with headache and unintentional body weight loss was also noted recently. Choroidal detachment simulating choroidal tumor was observed in the temporal quadrant. The 18F-fluoro-2-deoxyglucose (FDG) positron-emission tomography/computed tomography (CT) scan showed focal, mild to moderate FDG uptake in the left lateral orbit, and an enhanced lesion was seen on the recent CT scan...
June 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28642088/effect-of-pre-emptive-pregabalin-on-pain-management-in-patients-undergoing-laparoscopic-cholecystectomy-a-systematic-review-and-meta-analysis
#7
REVIEW
Yi Zhang, Yu Wang, Xi Zhang
BACKGROUND: Pre-emptive pregabalin might be beneficial to the patients undergoing laparoscopic cholecystectomy. However, the results remained controversial. We conducted a systematic review and meta-analysis to explore the effect of pregabalin on pain management of patients undergoing laparoscopic cholecystectomy. METHODS: PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases were systematically searched. Randomized controlled trials (RCTs) assessing the effect of pregabalin versus placebo on laparoscopic cholecystectomy were included...
June 19, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28642065/severe-and-resistant-hypertension-in-an-older-woman-with-claudication
#8
Puneet Gupta, Robert Hagberg, Electra Kaloudis, Anika Lucas, Parth Shah, William B White
Coarctation of the aorta is an uncommon cause of treatment-resistant hypertension in adults. It is typically detected and treated in infancy or childhood with surgical or endovascular procedures. Most cases of recurrence of coarctation after repair occur in childhood or early adulthood; recurrence in older persons (>70 years) has rarely been reported. A 73-year-old woman was referred to us for the management of treatment-resistant hypertension accompanied by symptoms of claudication and headaches, which had resulted in multiple emergency room visits...
June 1, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/28632833/-tetanus-after-cat-scratch-and-bites-in-a-previously-immunized-patient
#9
Alberto Fica, Daniela Gaínza, Pablo Ortigosa
Tetanus is declining due to vaccination, professional labor management and appropriate wound care. Tetanus cases have been reported despite immunization. We report the case of a previously healthy 21 years old female patient that presented a mild generalized tetanus requiring admission after mild and recurrent cat scratch and bites. She had received six vaccine shots during childhood, and a booster dose five years earlier after a rabbit bite. Symptoms appeared seven weeks after the last contact, and included headache, muscle spasms and mild opisthotonus...
April 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28627447/pain-with-traumatic-brain-injury-and-psychological-disorders
#10
REVIEW
Samar Khoury, Rodrigo Benavides
Traumatic brain injury (TBI) is the cause for long-term disability in more than 3 million patients in the US alone, with chronic pain being the most frequently reported complain. To date, predisposing mechanisms for chronic pain in TBI patients are largely unknown. Psychological disorders, including post-traumatic stress disorder, depression and anxiety following TBI are commonly reported comorbidities to post-traumatic pain. Long term consequences can be debilitating and affect quality of life even when the injury is mild...
June 13, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28626987/prolactinomas-diagnosed-in-the-postmenopausal-period-clinical-phenotype-and-outcomes
#11
Sandhya Santharam, Metaxia Tampourlou, Wiebke Arlt, John Ayuk, Neil Gittoes, Andrew Toogood, Rachel Webster, Niki Karavitaki
OBJECTIVE: Most prolactinomas in females are diagnosed during the reproductive age and the majority are microadenomas. Prolactinomas detected in the postmenopausal period are less common with limited published data on their presentation and prognosis. Our objective was to assess the presenting clinical, biochemical and imaging findings, as well as the outcomes of women diagnosed with a prolactinoma in the postmenopausal period. DESIGN AND METHODS: We undertook a retrospective cohort study of women diagnosed with prolactinoma after menopause and followed-up in a large UK pituitary center...
June 19, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28625338/acute-diplopia-in-the-pediatric-emergency-department-a-cohort-multicenter-italian-study
#12
Umberto Raucci, Pasquale Parisi, Nicola Vanacore, Francesco La Penna, Valentina Ferro, Lucia Calistri, Claudia Bondone, Fabio Midulla, Agnese Suppiej, Raffaele Falsaperla, Duccio Maria Cordelli, Antonella Palmieri, Alberto Verrotti, Sabrina Becciani, Sonia Aguzzi, Mario Mastrangelo, Federica Pelizza, Filippo Greco, Giulia Carbonari, Ramona Tallone, Gabriella Bottone, Italo Trenta, Stefano Masi, Maria Pia Villa, Antonino Reale
BACKGROUND: Acute diplopia (AD) is an uncommon and distressing symptom of numerous ocular and neurological conditions, with potentially serious sequelaes. No data are present in pediatrics on the presentation and management of AD. AIM: This study investigated characteristics, etiology and health care utilization of the pediatric population with AD accessed to pediatric Emergency Departments (ED), trying to identify "red flags" associated with potentially life-threatening (LT) conditions...
June 3, 2017: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/28620440/feeling-cold-and-other-underestimated-symptoms-in-breast-cancer-anecdotes-or-individual-profiles-for-advanced-patient-stratification
#13
REVIEW
Olga Golubnitschaja
Breast cancer (BC) epidemic is recognised as being characteristic for the early twenty-first century. BC is a multifactorial disease, and a spectrum of modifiable (preventable) factors significantly increasing risks has been described. This article highlights a series of underestimated symptoms for consequent BC risk assessment and patient stratification. Phenomena of the deficient thermoregulation, altered sensitivity to different stimuli (pain, thirst, smell, light, stress provocation), dehydration, altered circadian and sleep patterns, tendency towards headache, migraine attacks and dizziness, as well as local and systemic hypoxic effects are discussed for BC patients providing functional links and proposing new approaches in the overall BC management...
March 2017: EPMA Journal
https://www.readbyqxmd.com/read/28616776/evidence-towards-rna-binding-motif-rnp1-rrm-protein-3-rbm3-as-a-potential-biomarker-of-lithium-response-in-bipolar-disorder-patients
#14
Eleni Merkouri Papadima, Paola Niola, Carla Melis, Claudia Pisanu, Donatella Congiu, Cristiana Cruceanu, Juan Pablo Lopez, Gustavo Turecki, Raffaella Ardau, Giovanni Severino, Caterina Chillotti, Maria Del Zompo, Alessio Squassina
Lithium has been used for more than six decades for the management of bipolar disorder (BD). In a previous transcriptomic study, we showed that patients affected by either BD or cluster headache, both disorders characterized by circadian disturbances and response to lithium in a subgroup of patients, have higher expression of the RNA binding motif (RNP1, RRM) protein 3 (RBM3) gene compared to controls. To investigate whether RBM3 could represent a biomarker of lithium response, we screened raw microarray expression data from lymphoblastoid cell lines (LCLs) derived from 20 BD patients, responders or non-responders to lithium...
June 14, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28616557/dipyridamole-induced-adverse-effects-in-myocardial-perfusion-scans-dynamic-evaluation
#15
Sin-Di Lee, Wei-Chun Huang, Nan-Jing Peng, Chin Hu
AIM AND BACKGROUND: Dipyridamole-induced stress myocardial perfusion scans (MPS) has been widely used for management of coronary artery disease. The adverse effects of dipyridamole and other stress agents have been evaluated. The aim of this research is to confirm the dynamic data on dipyridamole side effects during MPS. METHODS: We collected data of 183 patients who underwent dipyridamole-induced stress MPS by retrospectively reviewing their clinical records, which included the severity of dipyridamole side effects in 3 min, 10 min, and 20 min after infusion...
March 2017: IJC Heart & Vasculature
https://www.readbyqxmd.com/read/28616054/an-investigation-on-non-invasive-fungal-sinusitis-molecular-identification-of-etiologic-agents
#16
Abdolrasoul Mohammadi, Seyed Mostafa Hashemi, Sayed Hamidreza Abtahi, Seyed Mohammad Lajevardi, Sahar Kianipour, Rasoul Mohammadi
BACKGROUND: Fungal sinusitis is increasing worldwide in the past two decades. It is divided into two types including invasive and noninvasive. Noninvasive types contain allergic fungal sinusitis (AFS) and fungus ball. AFS is a hypersensitivity reaction to fungal allergens in the mucosa of the sinonasal tract in atopic individuals. The fungus ball is a different type of noninvasive fungal rhinosinusitis which is delineated as an accumulation of debris and fungal elements inside a paranasal sinus...
2017: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/28615422/prognostic-factors-for-chronic-headache-a-systematic-review
#17
REVIEW
Katrin Probyn, Hannah Bowers, Fiona Caldwell, Dipesh Mistry, Martin Underwood, Manjit Matharu, Tamar Pincus
OBJECTIVE: To identify predictors of prognosis and trial outcomes in prospective studies of people with chronic headache. METHODS: This was a systematic review of published literature in peer-reviewed journals. We included (1) randomized controlled trials (RCTs) of interventions for chronic headache that reported subgroup analyses and (2) prospective cohort studies, published in English, since 1980. Participants included adults with chronic headache (including chronic headache, chronic migraine, and chronic tension-type headache with or without medication overuse headache)...
June 14, 2017: Neurology
https://www.readbyqxmd.com/read/28611643/uncommon-presentation-of-idiopathic-intracranial-hypertension-in-a-patient-with-polycystic-ovary-syndrome-a-case-report
#18
Anas Mohammad Albarrak, Suleiman Kojan
INTRODUCTION: Idiopathic intracranial hypertension is a rare condition characterized by increased intracranial pressure without clinical, laboratory, or radiological evidence of intracranial pathology. Early management could prevent irreversible outcomes. CASE PRESENTATION: A 17-year-old single Arabian female of Arab origin presented with a 2-day complaint of horizontal diplopia and transient visual obscurations. She denied any history of headache or decreased vision...
January 2017: Case Reports in Neurology
https://www.readbyqxmd.com/read/28611097/epidemiology-endovascular-treatment-and-prognosis-of-cerebral-venous-thrombosis-us-center-study-of-152-patients
#19
Kristin Salottolo, Jeffrey Wagner, Donald F Frei, David Loy, Richard J Bellon, Kathryn McCarthy, Judd Jensen, Christopher Fanale, David Bar-Or
BACKGROUND: Cerebral venous thrombosis is a rare cause of stroke that poses diagnostic, therapeutic, and prognostic challenges. Mainstay treatment is systemic anticoagulation, but endovascular treatment is increasingly advocated. Our objectives were to describe the epidemiology, treatment, and prognosis of 152 patients with cerebral venous thrombosis. METHODS AND RESULTS: This was a retrospective study of consecutive cerebral venous thrombosis cases from 2006 to 2013 at a comprehensive stroke center through hospital discharge...
June 13, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28610434/isoflavones-and-gastrointestinal-infection-two-potential-triggers-for-reversible-cerebral-vasoconstriction-syndrome
#20
Björn Machner, Tobias Boppel, Thomas Münte
Background Reversible cerebral vasoconstriction syndrome (RCVS) is an important differential diagnosis of singular or recurrent thunderclap headache. Prognosis is generally good, however complications of the transient segmental vasospasms of cerebral arteries such as stroke, subarachnoidal hemorrhage and brain edema may worsen the clinical outcome. Although the exact pathomechanism is still unclear, various vasoactive substances and conditions (e.g. post partum) have been identified as triggering RCVS. Cases We report on the clinical course and management of two cases of typical RCVS that were associated with two different precipitants previously not described: A gastrointestinal infection and isoflavones, which are phytoestrogens used for menopausal vasomotor symptoms...
January 1, 2017: Cephalalgia: An International Journal of Headache
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