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"Adult Growth Hormone Deficiency"

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https://www.readbyqxmd.com/read/27733224/management-of-adult-growth-hormone-deficiency-at-peking-union-medical-college-hospital-a-survey-among-physicians-%C3%A2
#1
Hong-Bo Yang, Meng-Qi Zhang, Hui Pan, Hui-Juan Zhu
<strong>Objective</strong> To evaluate physicians' attitude and knowledge about the management of adult growth hormone deficiency (AGHD) at Peking Union Medical College Hospital and impact factors associated with better decision-making.<strong>Methods</strong> A 21-question anonymous survey was distributed and collected at Peking Union Medical College Hospital, a major teaching hospital in Chinese Academy of Medical Sciences. Data of physicians' educational background, clinical training, patient workload per year and continuing medical education in AGHD were collected...
September 20, 2016: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
https://www.readbyqxmd.com/read/27520559/the-visceral-adiposity-index-is-associated-with-insulin-sensitivity-and-igf-i-levels-in-adults-with-growth-hormone-deficiency
#2
Alessandro Ciresi, Stefano Radellini, Valentina Guarnotta, Carla Giordano
The visceral adiposity index, based on anthropometric and metabolic parameters, has been shown to be related to adipose tissue function and insulin sensitivity. We aimed to evaluate the performance of the visceral adiposity index in adult patients with growth hormone deficiency. We enrolled 52 patients(mean age 51 ± 13 years) with newly diagnosed growth hormone deficiency and 50 matched healthy subjects as controls at baseline. At baseline and after 12 and 24 months of treatment we evaluated anthropometric measures, lipid profile, glucose and insulin during an oral glucose tolerance test, hemoglobin A1c, homeostasis model assessment estimate of insulin resistance, quantitative insulin sensitivity check index, insulin sensitivity index Matsuda, insulin-like growth factor-I and visceral adiposity index...
August 13, 2016: Endocrine
https://www.readbyqxmd.com/read/27472279/circulating-levels-of-irisin-in-hypopituitary-and-normal-subjects
#3
Lara Pena-Bello, Sonia Pértega-Diaz, Susana Sangiao-Alvarellos, Elena Outeiriño-Blanco, Raquel Eiras-Leal, Bárbara Varela-Rodriguez, Paula Juiz-Valiña, Miguel Pérez-Fontán, María Cordido, Fernando Cordido
CONTEXT: The recently identified myokine irisin conveys some of the benefits of exercise. Hypopituitarism with adult growth hormone deficiency (HP) is a situation characterized by decreased GH secretion and an altered body composition. OBJECTIVE: Our aim was to study the skeletal muscle hormone irisin in HP, and compare the results with a similar group of normal subjects. PARTICIPANTS AND METHODS: Seventeen HP patients and fifty-one normal subjects of similar age and sex were studied...
2016: PloS One
https://www.readbyqxmd.com/read/27409821/american-association-of-clinical-endocrinologists-american-college-of-endocrinology-disease-state-clinical-review-update-on-growth-hormone-stimulation-testing-and-proposed-revised-cut-point-for-the-glucagon-stimulation-test-in-the-diagnosis-of-adult-growth
#4
Kevin C J Yuen, Nicholas A Tritos, Susan L Samson, Andrew R Hoffman, Laurence Katznelson
INTRODUCTION: The clinical features of adult GH deficiency (GHD) are nonspecific, and GH stimulation testing is often required to confirm the diagnosis. However, diagnosing adult GHD can be challenging due to the episodic and pulsatile GH secretion, concurrently modified by age, gender, and body mass index (BMI). METHODS: PubMed searches were conducted to identify published data since 2009 on GH stimulation tests used to diagnose adult GHD. Relevant articles in English language were identified and considered for inclusion in the present document...
July 13, 2016: Endocrine Practice
https://www.readbyqxmd.com/read/27293538/seven-years-of-follow-up-of-trabecular-bone-score-bone-mineral-density-body-composition-and-quality-of-life-in-adults-with-growth-hormone-deficiency-treated-with-rhgh-replacement-in-a-single-center
#5
Gonzalo Allo Miguel, Alicia Serraclara Plá, Myriam Lorena Partida Muñoz, Guillermo Martínez Díaz-Guerra, Federico Hawkins
BACKGROUND: Adult growth hormone deficiency (AGHD) is characterized by impaired physical activity, diminished quality of life (QoL), weight and fat mass gain, decreased muscle mass and decreased bone mineral density (BMD). The aim of this study was to evaluate the effects of long-term treatment (7 years) with recombinant human growth hormone (rhGH) on metabolic parameters, body composition (BC), BMD, bone microarchitecture and QoL. PATIENTS AND METHODS: In this prospective study, BMD and BC were assessed by dual-energy X-ray absorptiometry (DXA)...
June 2016: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27123781/lipid-accumulation-product-a-simple-and-accurate-index-for-predicting-metabolic-syndrome-in-patients-with-adult-growth-hormone-deficiency
#6
L Chan, H Xue, Z Xiaoya, X Jiajia, R Wei, L Linman, L Qing, L Lan
PURPOSE: It has been demonstrated that metabolic risk factors were increased in adult growth hormone deficiency (AGHD) patients. Lipid accumulation product (LAP) is a novel biomarker of central lipid accumulation related to risk of metabolic syndrome (MS), diabetes and cardiovascular disease. The aim of this study was to investigate the ability of LAP to identify MS in AGHD Patients. MATERIALS AND METHODS: In this cross-sectional study, 75 AGHD patients and 75 controls matched with age and gender were enrolled...
April 2016: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/27118206/comparison-of-low-normal-and-high-normal-igf-1-target-levels-during-growth-hormone-replacement-therapy-a-randomized-clinical-trial-in-adult-growth-hormone-deficiency
#7
Christa C van Bunderen, Paul Lips, Mark H Kramer, Madeleine L Drent
BACKGROUND: Current guidelines state that the goals of growth hormone (GH) therapy in adults should be an appropriate clinical response, avoidance of side effects, and an IGF-1 value within the age-adjusted reference range. There are no published studies on the target level for IGF-1 that offer specific guidance in this regard. OBJECTIVES: To compare low-normal and high-normal target levels of IGF-1 on efficacy and safety of GH treatment. METHODS: A randomized, open-label, clinical trial including thirty-two adults from one university hospital receiving GH therapy for at least one year with a stable IGF-1 concentration between -1 and 1 SD score (SDS)...
June 2016: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/26944562/effects-of-discontinuation-of-growth-hormone-replacement-in-adult-gh-deficient-patients-a-cohort-study-and-a-systematic-review-of-the-literature
#8
Natasha M Appelman-Dijkstra, Marnick Rijndorp, Nienke R Biermasz, Olaf M Dekkers, Alberto M Pereira
BACKGROUND: Recombinant human growth hormone (rhGH) replacement is advocated in adult growth hormone-deficient (GHD) patients to increase bone mass and improve lipid profile, body composition, and quality of life. The long-term effects of discontinuation of rhGh replacement are unknown. METHODS: This cohort study and systematic review aim to evaluate the long-term metabolic effects of discontinuation of rhGh replacement in adult GHD patients, with a subgroup analyses according to age (< or > 60 years)...
June 2016: European Journal of Endocrinology
https://www.readbyqxmd.com/read/26727076/reversible-albumin-binding-gh-possesses-a-potential-once-weekly-treatment-profile-in-adult-growth-hormone-deficiency
#9
RANDOMIZED CONTROLLED TRIAL
Michael Højby Rasmussen, Jurgita Janukonyté, Marianne Klose, Djordje Marina, Mette Tanvig, Lene F Nielsen, Charlotte Höybye, Marianne Andersen, Ulla Feldt-Rasmussen, Jens Sandahl Christiansen
CONTEXT: NNC0195-0092 is a reversible, albumin-binding GH derivative, developed for once-weekly administration. OBJECTIVES: The objective of the study was to evaluate safety, local tolerability, pharmacodynamics, and pharmacokinetics of multiple, once-weekly doses of NNC0195-0092, compared with daily GH. DESIGN AND SETTING: This was a phase 1, randomized, open-label, active-controlled, multiple-dose, dose-escalation trial. PATIENTS: Thirty-four GH-treated adult subjects (male, n = 25) with GH deficiency participated in the study...
March 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/26574788/trends-in-growth-hormone-stimulation-testing-and-growth-hormone-dosing-in-adult-growth-hormone-deficiency-patients-results-from-the-answer-program
#10
Murray B Gordon, Richard A Levy, Robert Gut, John Germak
OBJECTIVE: Adult growth hormone deficiency (AGHD) results in physiologic impairments that may reduce quality of life and negatively impact body composition. AGHD can be treated with recombinant human growth hormone (GH). This study analyzes AGHD patients enrolled in the American Norditropin(®) STUDIES: Web-Enabled-Research (ANSWER) Program/NovoNet, a U.S. observational noninterventional study of patients treated with Norditropin(®) (somatropin [recombinant DNA origin] injection) at the discretion of their physicians...
April 2016: Endocrine Practice
https://www.readbyqxmd.com/read/26300280/impact-of-adult-growth-hormone-deficiency-on-metabolic-profile-and-cardiovascular-risk-review
#11
Lara Giovannini, Giacomo Tirabassi, Giovanna Muscogiuri, Carolina Di Somma, Annamaria Colao, Giancarlo Balercia
Adult growth hormone deficiency (GHD) is a well defined clinical condition, which is characterized by abnormal body composition, impaired physical activity and decreased quality of life. In addition, in recent years, growing interest has been shown towards cardiovascular risks in adult patients affected by GHD. In this regard, GHD is widely known to be associated with increased mortality, likely due to the increase of risk factors, such as central obesity, impaired lipid and glucose profiles and other less-known risk factors, such as inflammatory cytokines, endothelial dysfunction and oxidative stress...
2015: Endocrine Journal
https://www.readbyqxmd.com/read/26236803/adult-growth-hormone-deficiency-current-concepts
#12
Izumi Fukuda, Naomi Hizuka, Toko Muraoka, Atsuhiro Ichihara
The clinical syndrome of adult growth hormone deficiency (AGHD) was widely recognized in the 1980s. In this review, we first describe the clinical features and diagnosis of AGHD and then state the effects of growth hormone (GH) therapy for these patients. The main characteristics of AGHD are abnormal body composition, dyslipidemia, insulin resistance, and an impaired quality of life (QoL) due to decreased psychological well-being. For diagnosing AGHD, the international consensus guidelines have suggested that an insulin tolerance test (ITT) is the gold standard, but in Japan, the growth hormone releasing peptide-2 (GHRP-2) test is available and is recommended as a convenient and safe GH stimulating test...
2014: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/26064207/correlation-of-increased-plasma-osteoprotegerin-and-cardiovascular-risk-factors-in-patients-with-adult-growth-hormone-deficiency
#13
Jiajia Xia, Linman Li, Wei Ren, Xiaoya Zheng, Chan Liu, Jinchao Li, Tingying Chen, Xiaofeng Li, Lingli Wang, Yumei Hu
Adult growth hormone deficiency (AGHD) is correlated to many adverse effects on metabolism and increases cardiovascular risk. 40 patients with AGHD and 40 healthy subjects were included. Anthropometric parameters such as body mass index, waist circumference, and waist-hip ratio were measured. Meanwhile, plasma levels of total cholesterol, triglyceride, high sensitivity C-relative protein, interleukin-6 and OPG were determined. Homeostasis model assessments for insulin resistance (HOMA-IR) and β-cell function (HOMA-β) were calculated using homeostasis model...
2015: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/25732649/hypopituitarism-growth-hormone-and-corticotropin-deficiency
#14
REVIEW
Cristina Capatina, John A H Wass
This article presents an overview of adult growth hormone deficiency (AGHD) and corticotropin deficiency (central adrenal failure, CAI). Both conditions can result from various ailments affecting the hypothalamus or pituitary gland (most frequently a tumor in the area or its treatment). Clinical manifestations are subtle in AGHD but potentially life-threatening in CAI. The diagnosis needs dynamic testing in most cases. Treatment of AGHD is recommended in patients with documented severe deficiency, and treatment of CAI is mandatory in all cases...
March 2015: Endocrinology and Metabolism Clinics of North America
https://www.readbyqxmd.com/read/25406443/impact-of-adult-growth-hormone-deficiency-on-daily-functioning-and-well-being
#15
Meryl Brod, Betsy Pohlman, Lise Højbjerre, Johan Erpur Adalsteinsson, Michael Højby Rasmussen
BACKGROUND: Adult Growth Hormone Deficiency (AGHD) is a debilitating condition resulting from tumors, pituitary surgery, radiation of the head, head injury, or hypothalamic-pituitary disease. This qualitative study was conducted to better understand the multi-faceted impacts and treatment effects of GHD on adult patients' daily lives.Seven focus groups and four telephone interviews were conducted in three countries. Eligible AGHD patients were age 22 or older who had started and stopped growth hormone treatment at least once as an adult...
2014: BMC Research Notes
https://www.readbyqxmd.com/read/25116471/long-term-effects-of-growth-hormone-replacement-therapy-on-liver-function-in-adult-patients-with-growth-hormone-deficiency
#16
Ryusaku Matsumoto, Hidenori Fukuoka, Genzo Iguchi, Hitoshi Nishizawa, Hironori Bando, Kentaro Suda, Michiko Takahashi, Yutaka Takahashi
OBJECTIVE: Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are frequently observed in patients with adult growth hormone deficiency (AGHD) and short-term GH replacement therapy (GHRT) has reportedly been efficacious in NAFLD and NASH. The aim of this study was to investigate whether long-term GHRT is an effective treatment for the hepatic comorbidities in AGHD. DESIGN: This is a retrospective observational study. We recruited 54 consecutive hypopituitary patients with AGHD...
October 2014: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/25070016/adult-growth-hormone-deficiency-current-concepts
#17
REVIEW
Izumi Fukuda, Naomi Hizuka, Toko Muraoka, Atsuhiro Ichihara
The clinical syndrome of adult growth hormone deficiency (AGHD) was widely recognized in the 1980s. In this review, we first describe the clinical features and diagnosis of AGHD and then state the effects of growth hormone (GH) therapy for these patients. The main characteristics of AGHD are abnormal body composition, dyslipidemia, insulin resistance, and an impaired quality of life (QoL) due to decreased psychological well-being. For diagnosing AGHD, the international consensus guidelines have suggested that an insulin tolerance test (ITT) is the gold standard, but in Japan, the growth hormone releasing peptide-2 (GHRP-2) test is available and is recommended as a convenient and safe GH stimulating test...
2014: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/25060235/contextualized-analysis-of-a-needs-assessment-using-the-theoretical-domains-framework-a-case-example-in-endocrinology
#18
Patrice Lazure, Robert C Bartel, Beverly M K Biller, Mark E Molitch, Stephen M Rosenthal, Judith L Ross, Brock D Bernsten, Sean M Hayes
BACKGROUND: The Theoretical Domains Framework (TDF) is a set of 14 domains of behavior change that provide a framework for the critical issues and factors influencing optimal knowledge translation. Considering that a previous study has identified optimal knowledge translation techniques for each TDF domain, it was hypothesized that the TDF could be used to contextualize and interpret findings from a behavioral and educational needs assessment. To illustrate this hypothesis, findings and recommendations drawn from a 2012 national behavioral and educational needs assessment conducted with healthcare providers who treat and manage Growth and Growth Hormone Disorders, will be discussed using the TDF...
2014: BMC Health Services Research
https://www.readbyqxmd.com/read/25037883/impact-of-moderate-interval-exercise-versus-supine-rest-on-the-pharmacokinetics-and-pharmacodynamic-profiles-of-subcutaneously-administered-growth-hormone-in-adult-growth-hormone-deficient-patients
#19
RANDOMIZED CONTROLLED TRIAL
J Janukonytė, T Parkner, T Lauritzen, J S Christiansen, J Frystyk, H S Pedersen, T Laursen
BACKGROUND: Diurnal variation in serum growth hormone (s-GH) levels after exogenous GH delivery has previously been reported in patients with no endogenous GH secretion. Changes in postural position or physical activity, leading to changes in blood flow and/or lymphatic drainage may be underlying explanations. PRIMARY OBJECTIVES: The primary aim of this study is to study a possible impact of exercise and supine rest on pharmacokinetics (PK) and day-to-day variation of subcutaneously (s...
October 2014: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/24995855/growth-hormone-ameliorates-adipose-dysfunction-during-oxidative-stress-and-inflammation-and-improves-glucose-tolerance-in-obese-mice
#20
M Fukushima, Y Okamoto, H Katsumata, M Ishikawa, S Ishii, M Okamoto, S Minami
Patients with adult growth hormone deficiency exhibit visceral fat accumulation, which gives rise to a cluster of metabolic disorders such as impaired glucose tolerance and dyslipidemia. Plasma growth hormone levels are lower in obese patients with metabolic syndrome than in healthy subjects. Here we examined the hypothesis that exogenous growth hormone administration regulates function of adipose tissue to improve glucose tolerance in diet-induced obese mice. Twelve-week-old obese male C57BL/6 J mice received bovine growth hormone daily for 6 weeks...
August 2014: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
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