Joshua Godoy Coto, Erica V Pereyra, Fiorella A Cavalli, Carlos A Valverde, Claudia I Caldiz, Sabina M Maté, Alejandra M Yeves, Irene L Ennis
The myocardium is a highly oxidative tissue in which mitochondria are essential to supply the energy required to maintain pump function. When pathological hypertrophy develops, energy consumption augments and jeopardizes mitochondrial capacity. We explored the cardiac consequences of chronic swimming training, focusing on the mitochondrial network, in spontaneously hypertensive rats (SHR). Male adult SHR were randomized to sedentary or trained (T: 8-week swimming protocol). Blood pressure and echocardiograms were recorded, and hearts were removed at the end of the training period to perform molecular, imaging, or isolated mitochondria studies...
April 16, 2024: Pflügers Archiv: European Journal of Physiology