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Semax

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https://www.readbyqxmd.com/read/27591879/changes-in-sympathetic-innervation-of-rat-caudal-artery-in-experimental-myocardial-infarction-effect-of-semax-peptide
#1
A M Gorbacheva, A B Berdalin, A N Stulova, A D Nikogosova, M D Lin, S V Buravkov, S A Gavrilova, V B Koshelev
Activation of the sympathetic nervous system aggravates the course of myocardial infarction. Semax peptide moderated the degree of this activation and prevented the increase in the density of sympathetic endings in rat caudal artery in 28 days after ischemia or ischemia/reperfusion. The peptide reduced the density of α-adrenoreceptors in the caudal artery of rats with myocardial infarction. Semax produced no effect on β-adrenoreceptors in both experimental models. The experiments on isolated segments of the caudal artery revealed reduced vascular responsiveness to electrical stimulation and norepinephrine infusion in rats treated with Semax after ischemia/reperfusion injury...
August 2016: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27586814/influence-of-the-n-terminus-acetylation-of-semax-a-synthetic-analog-of-acth-4-10-on-copper-ii-and-zinc-ii-coordination-and-biological-properties
#2
Antonio Magrì, Giovanni Tabbì, Alessandro Giuffrida, Giuseppe Pappalardo, Cristina Satriano, Irina Naletova, Vincenzo G Nicoletti, Francesco Attanasio
Semax is a heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) that encompasses the sequence 4-7 of N-terminal domain of the adrenocorticotropic hormone and a C-terminal Pro-Gly-Pro tripeptide. N-terminal amino group acetylation (Ac-Semax) modulates the chemical and biological properties of parental peptide, modifying the ability of Semax to form complex species with Cu(II) ion. At physiological pH, the main complex species formed by Ac-Semax, [CuLH-2](2-), consists in a distorted CuN3O chromophore with a weak apical interaction of the methionine sulphur...
August 27, 2016: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/27411820/semax-prevents-learning-and-memory-inhibition-by-heavy-metals
#3
A N Inozemtsev, S B Bokieva, O V Karpukhina, K Z Gumargalieva, A A Kamensky, N F Myasoedov
Separate and joint effect of Semax, ascorbic acid, lead diacetate, and ammonium molybdate on avoidance conditioning in rats was studied. It was established that the heavy metal salts inhibited the avoidance response, and the peptide counteracted this inhibition as strongly as ascorbic acid or to a comparable degree. These findings confirm the antioxidant properties of Semax.
May 2016: Doklady Biological Sciences: Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections
https://www.readbyqxmd.com/read/26591577/-the-effect-of-acth-4-7-pgp-peptide-on-lipid-peroxidation-in-liver-and-activity-of-serum-transaminases-in-rats-under-acute-and-chronic-immobilization-stress-conditions
#4
I Bobyntsev, A A Kryukov, M Shepeleva, A V Ivanov
The effect of ACTH-(4-7)-PGP (semax) intraperitoneal injection at doses of 5, 50, 150 and 450 μg/kg b.w. on the free-radical oxidation and the activity of serum transaminases in Wistar male rats subjected to acute and chronic immobilization stress has been studied. It was found that the peptide administration in the entire dose range studied produced antioxidant effect in hepatocytes and significantly increased the activity of serum ALT and AST at a dose of 450 μg/kg under chronic stress conditions. On the contrary, prooxidant effects were observed at a drug dose of 150 mg/kg under acute stress conditions, and the direction of changes in the ALT and AST values activity depended on the semax dose...
2015: Eksperimental'naia i Klinicheskaia Farmakologiia
https://www.readbyqxmd.com/read/26552305/-effect-of-peptide-semax-on-synaptic-activity-and-short-term-plasticity-of-glutamatergic-synapses-of-co-cultured-dorsal-root-ganglion-and-dorsal-horn-neurons
#5
M S Shypshyna, N S Veselovsky, N F Myasoedov, S I Shram, S A Fedulova
The influence of long-term culturing (12 days in vitro) of dorsal root ganglion (DRG) and dorsal horn (DH) neurons with peptide Semax on the level of synaptic activity at co-cultures, as well as short-term plasticity in sensory synapses were studied. It has been shown that neuronal culturing with peptide at concentrations of 10 and 100 µM led to increasing the frequency of spontaneous glutamatergic postsynaptic currents in DH neurons to 71.7 ± 1.8% and 93.9 ± 3.1% (n = 6; P < 0.001); Semax has a not significant effect on the amplitude and frequency of miniature glutamatergic currents, but causes an increase of the amplitudes of spontaneous postsynaptic currents, as well as elevates the quantum content...
2015: Fiziolohichnyĭ Zhurnal
https://www.readbyqxmd.com/read/26012109/-the-effect-of-peptide-acth4-7-pgp-on-functional-hepatocyte-state-in-rats-in-acute-and-chronic-foot-shock-stress
#6
I I Bobyntsev, O M Shepeleva, A A Kryukov, A V Ivanov, A E Belykh
The effect of ACTH4-7-PGP (Semax) intraperitoneal injection at the doses of 5, 50, 150 and 450 μg/kg b. w. on lipid peroxidation and functional hepatocytes state in Wistar male rats subjected to acute and chronic electrical foot-shock stress was investigated. It was observed that peptide at the doses of 50 and 450 μg/kg normalized malondialdehyde (MDA) level elevation in the liver homogenate caused by acute foot-shock stress. On the contrary, at the doses of 5 and 150 μg/kg Semax significantly increased MDA content without essential changes of antioxidant defense activity (catalase, superoxide dismutase, common antioxidative activity)...
February 2015: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
https://www.readbyqxmd.com/read/25850296/-effect-of-tripeptide-pro-gly-pro-on-rat-brain-transcriptome-in-focal-ischemia
#7
E V Medvedeva, V G Dmitrieva, O V Povarova, S A Limborskaia, V I Skvortsova, N F Miasoedov, L V Dergunova
Biologically active regulatory peptide, tripeptide Pro-Gly-Pro (PGP) was used as C-terminal fragment for peptide drugs Semax and Selank. In recent years the independent effects of PGP were observed. The question was raised, whether PGP contributes to the effects ofpeptide drugs containing PGP as a fragment. The genome-wide analysis was performed to investigate the influence of PGP on the transcriptome of ischemic rat brain cortex tissues. The gene expression alterations caused by the action of the tripeptide PGP were compared with the gene expression of the control group "ischemia" at 3 and 24 h after permanent occlusion of left middle cerebral artery...
March 2014: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/25826866/-study-of-neuroprotective-antihypoxic-and-antiamnesic-effects-of-new-mixture-of-tripeptides
#8
V V Iasnetsov, E A Chertorizhskiĭ, P A Belyĭ, Zh D Bespalova, M V Ovchinnikov, A O Vereshchagina, Iu V Ivanov, Vik V Iasnetsov, S K Kirsanova, V G Motin
A new mixture of tripeptides (NMT: H-Lys-Asp-Glu-OH, H-Asp-Glu-Pro-OH, H-Asp-Glu-Arg-OH) in doses of 150 and 300 mg/kg per day produces clearly pronounced neuroprotective effect in rats with brain ischemia and decreases neurologic deficiency 1.1 times more effectively than reference drug semax. NMT (10, 50 and 150 mg/kg) had marked antihypoxic effect on mice in hermetic and altitude chamber. NMT in doses of 10 and 50 mg/kg was more effective than semax in hermetic chamber (1.3 and 1.5 times, respectively) and in a dose of 150 mg/kg in altitude chamber (1...
2015: Eksperimental'naia i Klinicheskaia Farmakologiia
https://www.readbyqxmd.com/read/25772990/the-action-of-the-peptide-drug-semax-on-the-currents-of-ampa-receptors-of-rat-cerebellar-purkinje-cells
#9
V V Grigoriev, L A Andreeva, V L Zamoyski, V P Shevchenko, S O Bachurin, N F Myasoedov
No abstract text is available yet for this article.
2015: Doklady. Biochemistry and Biophysics
https://www.readbyqxmd.com/read/25735182/-effects-of-neonatal-fluvoxamine-administration-to-white-rats-and-their-correction-by-semax-treatment
#10
M A Volodina, S A Merchieva, E A Sebentsova, N Iu Glazova, D M Manchenko, L A Andreeva, N G Levickaia, A A Kamenskiĭ, N F Miasoedov
The aim of this work was to study the delayed effects of chronic neonatal administration of the selective serotonin reuptake inhibitor fluvoxamine (FA) to white rat pups and to estimate the possibility to correct these effects by treatment with semax. Fluvoxamine was injected intraperitoneally at a dose of 10 mg/kg from postnatal days 1 to 14, and semax was injected intranasally at a dose of 0.05 mg/kg from postnatal days 15 to 28. It was shown that neonatal FA administration produced a significant delay in animal somatic growth...
July 2014: Izvestiia Akademii Nauk. Seriia Biologicheskaia
https://www.readbyqxmd.com/read/25508392/-opposite-semax-influence-on-conditioning-and-functional-disturbances-of-avoidance-responses-in-rats
#11
(no author information available yet)
Semax effects on formation of active avoidance reaction in rats in different experimental models have been studied. It was shown that intraperitoneal Semax administration at a dose of 0.05 mg/kg accelerated acquisition of one-way active avoidance response when rats were trained to avoid electric foot-shock by jumping on the shelf. When rats were trained in shuttle-box the peptide increased the electroshock threshold value required to provocation of rat moving in experimental box and delayed acquisition of two-way active avoidance response...
November 2013: Zhurnal Vyssheĭ Nervnoĭ Deiatelnosti Imeni I P Pavlova
https://www.readbyqxmd.com/read/25464761/-opposite-semax-influence-on-conditioning-and-functional-disturbances-of-avoidance-responses-in-rats
#12
A N Inozemtsev, A E Agapitova, S B Bokieva, N Iu Glazova, N G Levitskaia, A A Kamenskiĭ, N F Miasoedov
Semax effects on formation of active avoidance reaction in rats in different experimental models have been studied. It was shown that intraperitoneal Semax administration at a dose of 0.05 mg/kg accelerated acquisition of one-way active avoidance response when rats were trained to avoid electric foot-shock by jumping on the shelf. When rats were trained in shuttle-box the peptide increased the electroshock threshold value required to provocation of rat moving in experimental box and delayed acquisition of two-way active avoidance response...
November 2013: Zhurnal Vyssheĭ Nervnoĭ Deiatelnosti Imeni I P Pavlova
https://www.readbyqxmd.com/read/25310602/semax-an-acth4-10-peptide-analog-with-high-affinity-for-copper-ii-ion-and-protective-ability-against-metal-induced-cell-toxicity
#13
Giovanni Tabbì, Antonio Magrì, Alessandro Giuffrida, Valeria Lanza, Giuseppe Pappalardo, Irina Naletova, Vincenzo Giuseppe Nicoletti, Francesco Attanasio, Enrico Rizzarelli
Heptapeptide Semax, encompassing the sequence 4-7 of N-terminal domain of the adrenocorticotropic hormone (ACTH) and a C-terminal Pro-Gly-Pro tripeptide, belongs to a short regulatory peptides family. This compound has been found to affect learning processes and to exert marked neuroprotective activities on cognitive brain functions. Dys-homeostasis of metal ions is involved in several neurodegenerative disorders and growing evidences have showed that brain is a specialized organ able to concentrate metal ions...
January 2015: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/25102733/-antiaggregation-activity-of-arachidonic-acid-conjugates-with-neurotropic-peptides-proglyprol-and-semax
#14
V V Bezuglov, N M Gretskaia, T M Vasil'eva, G N Petrukhina, L A Andreeva, N F Miasoedov, V A Makarov
The influence two original derivatives of a therapeutically important peptide, bearing arachidonic acid residue with semax and proglyprol, upon platelet aggregation have been studied in vitro. It is established that both derivatives, in contrast to the parent peptide, possess moderate anti-aggregant properties and produce a dose-dependent decrease in the interplatelet interaction induced by ADP, epinephrine, and arachidonic acid within the concentration range of 0.018 - 1.8 mM. This activity was more pronounced for arachidonoylsemax in comparison with arachidonoylproglyprol...
2014: Eksperimental'naia i Klinicheskaia Farmakologiia
https://www.readbyqxmd.com/read/24877185/sigmoidal-maximal-effect-modeling-of-low-density-lipoprotein-cholesterol-concentration-and-annual-incidence-of-coronary-heart-disease-events-in-secondary-prevention-trials
#15
REVIEW
Scott L Charland, Eric J Stanek
STUDY OBJECTIVES: To evaluate the relationship between low-density lipoprotein cholesterol (LDL-C) concentration and the annual incidence of combined coronary heart disease (CHD) events—death or nonfatal myocardial infarction (NFMI)—by using sigmoidal maximal effect (sEmax) modeling of published data in various populations at risk for CHD events, and to use the best performing sEmax model generated to calculate the number needed to treat (NNT) to prevent a single CHD death or NFMI event across a range of LDL-C concentrations...
May 2014: Pharmacotherapy
https://www.readbyqxmd.com/read/24738258/-neuroprotective-effects-of-peptides-bioregulators-in-people-of-various-age
#16
REVIEW
R S Umnov, N S Lin'kova, V Kh Khavinson
The review presents comparative characteristics of 2 peptide neuroprotective groups: polypeptide complexes (cortexin, cerebrolizin) and short peptides (semax, kortagen, pinealon). The data of clinical applying of peptides in elderly and old age people and cellular and molecular mechanisms of their neuroprotective activity is described.
2013: Advances in Gerontology, Uspekhi Gerontologii
https://www.readbyqxmd.com/read/24661604/the-peptide-semax-affects-the-expression-of-genes-related-to-the-immune-and-vascular-systems-in-rat-brain-focal-ischemia-genome-wide-transcriptional-analysis
#17
Ekaterina V Medvedeva, Veronika G Dmitrieva, Oksana V Povarova, Svetlana A Limborska, Veronika I Skvortsova, Nikolay F Myasoedov, Lyudmila V Dergunova
BACKGROUND: The nootropic neuroprotective peptide Semax (Met-Glu-His-Phe-Pro-Gly-Pro) has proved efficient in the therapy of brain stroke; however, the molecular mechanisms underlying its action remain obscure. Our genome-wide study was designed to investigate the response of the transcriptome of ischemized rat brain cortex tissues to the action of Semax in vivo. RESULTS: The gene-expression alteration caused by the action of the peptide Semax was compared with the gene expression of the "ischemia" group animals at 3 and 24 h after permanent middle cerebral artery occlusion (pMCAO)...
March 24, 2014: BMC Genomics
https://www.readbyqxmd.com/read/24437205/-the-results-of-the-application-of-the-pre-formed-physical-factors-and-neuroprotective-therapy-for-the-rehabilitative-treatment-of-the-patients-with-diabetic-retinopathy
#18
COMPARATIVE STUDY
G A Nazarova, T V Konchugova, O V Iurova, E A Turova, M A Rassulova, N V Sichinava, N E Morozova
To evaluate the effectiveness of the neuroprotective agent used to treat the patients presenting with non-proliferative diabetic retinopathy. The study included 114 patients (228 eyes) at the age varying from 42 to 70 who presented with diabetes mellitus and non-proliferative diabetic retinopathy. Three groups were formed depending on the mode of treatment. The patients in main group underwent endonasal electrophoresis of 0.1% semax preparation. Patients of the comparison group were treated with intranasal instillations of semax and those of the control group received only standard hypoglycemic therapy and treatment with Doxy-Hem...
September 2013: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/24397030/-proteolysis-of-simple-glyprolines-by-leucine-aminopeptidase-and-enzymes-from-nasal-slime-brain-membranes-and-rat-blood
#19
K V Shevchenko, T V V'iunova, I Iu Nagaev, L A Andreeva, N F Miasoedov
Proteolysis of Pro-Gly-Pro-Leu, Pro-Gly-Pro-Gly and Pro-Gly-Pro were studied comparatively to Met-Glu-His-Phe-Pro-Gly-Pro (semax). It is shown that all three peptides are considerably more stable to proteolysis by N-leucine-aminopeptidase (EC 3.4.11.1, Sigma, type VI, 9.2 units/mg), and by enzymes of nasal slime, brain microsomal fractions, and rat blood. Metabolites of the proteolysis showed that semax derives His-Phe-Pro-Gly-Pro only, Pro-Gly-Pro-Leu forms Gly-Pro-Leu, Pro-Gly-Pro and Gly-Pro, Pro-Gly-Pro-Gly gives Pro-Gly-Pro and Gly-Pro, and Pro-Gly-Pro forms Gly-Pro...
May 2013: Bioorganicheskaia Khimiia
https://www.readbyqxmd.com/read/24385169/heptapeptide-semax-attenuates-the-effects-of-chronic-unpredictable-stress-in-rats
#20
K A Yatsenko, N Yu Glazova, L S Inozemtseva, L A Andreeva, A A Kamensky, I A Grivennikov, N G Levitskaya, O V Dolotov, N F Myasoedov
No abstract text is available yet for this article.
November 2013: Doklady Biological Sciences: Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections
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