keyword
MENU ▼
Read by QxMD icon Read
search

Smart drugs

keyword
https://www.readbyqxmd.com/read/29220150/functionalized-eu-iii-based-nanoscale-metal-organic-framework-to-achieve-near-ir-triggered-and-targeted-two-photon-absorption-photodynamic-therapy
#1
Jianguo Jia, Yang Zhang, Min Zheng, Changfu Shan, Huicheng Yan, Wenyu Wu, Xuan Gao, Bo Cheng, Weisheng Liu, Yu Tang
The postsynthetic-modified nanoscale metal-organic framework (NMOF) probes selected as potential drug delivery platforms and photodynamic therapy agents to fulfill the effective and safe treatment of neoplastic diseases have attracted increasing attention recently. Herein, a Eu(III)-based NMOF probe elaborately postsynthetically modified with a β-diketonate two-photon-absorbing (TPA) ligand is rationally designed and further functionalized by assembling the photosensitizer molecule (methylene blue, MB) in the pores and a cyclic peptide targeting motif on the surface of the NMOF, which could achieve highly efficient near-infrared (NIR)-triggered and -targeted photodynamic therapy (PDT)...
December 8, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29218857/the-combined-effect-of-thermal-and-chemotherapy-on-hela-cells-using-magnetically-actuated-smart-textured-fibrous-system
#2
Pranav Tiwari, Sakshi Agarwal, Sachchidanand Srivastava, Shilpee Jain
Thermal therapy combined with chemotherapy is one of the advanced and efficient methods to eradicate cancer. In this work, we fabricated magnetically actuated smart textured (MAST) fibrous systems and studied their candidacy for cancer treatment. The polycaprolactone-Fe3 O4 based MAST fibers were fabricated using electrospinning technique. These MAST fibrous systems contained carbogenic quantum dots as a tracking agent and doxorubicin hydrochloride anticancer drug. Additionally, as fabricated MAST fibrous systems were able to deliver anticancer drug and heat energy simultaneously to kill HeLa cells in a 10 min period in vitro...
January 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29216759/pharmaceutical-potential-of-quantum-dots
#3
Swati Jha, Prateek Mathur, Suman Ramteke, Narendra Kumar Jain
Quantum dots (QDs) or fluorescent nanocrystals are designed nanoparticles that are promising for several biological and bio-medical applications as well as drug delivery and simultaneous cellular imaging. QD's have exhibited promising potential primarily in receptor based targeting as a result of their distinctive physicochemical properties. Functionalized QDs (f-QDs) have been developed as effective, safe, nano-sized smart systems to deliver a wide range of bio-actives. Surface modified fluorescent carbon QDs with surface modification have attracted attention as targeting ligand to accomplish cellular targeting with enhanced specificity...
December 7, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29197586/ph-sensitive-polymeric-nanoparticles-with-antioxidant-and-anti-inflammatory-properties-against-cisplatin-induced-hearing-loss
#4
Sergio Martín-Saldaña, Raquel Palao-Suay, María Rosa Aguilar, Luis García-Fernández, Humberto Arévalo, Almudena Trinidad, Rafael Ramírez-Camacho, Julio San Román
Polymeric nanoparticles (NP) based on smart synthetic amphiphilic copolymers are used to transport and controlled release dexamethasone in the inner ear to protect against the ototoxic effect of cisplatin. The NP were based on a mixture of two pseudo-block polymer drugs obtained by free radical polymerization: poly(VI-co-HEI) and poly(VP-co-MVE) or poly(VP-co-MTOS), being VI 1-vinylimidazole, VP N-vinylpyrrolidone, and IBU, MVE and MTOS the methacrylic derivatives of ibuprofen, α-tocopherol and α-tocopheryl succinate, respectively...
November 29, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29195229/photo-triggered-destabilization-of-nanoscopic-vehicles-by-dihydroindolizine-for-enhanced-anticancer-drug-delivery-in-cervical-carcinoma
#5
Priya Singh, Susobhan Choudhury, Senthilguru Kulanthaivel, Damayanti Bagchi, Indranil Banerjee, Saleh A Ahmed, Samir Kumar Pal
The efficacy and toxicity of drugs depend not only on their potency but also on their ability to reach the target sites in preference to non-target sites. In this regards destabilization of delivery vehicles induced by light can be an effective strategy for enhancing drug delivery with spatial and temporal control. Herein we demonstrate that the photoinduced isomerization from closed (hydrophobic) to open isomeric form (hydrophilic) of a novel DHI encapsulated in liposome leads to potential light-controlled drug delivery vehicles...
November 15, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29191005/construction-of-high-drug-loading-and-enzymatic-degradable-multilayer-films-for-self-defense-drug-release-and-long-term-biofilm-inhibition
#6
Bailiang Wang, Huihua Liu, Lin Sun, Yingying Jin, Xiaoxu Ding, Lingli Li, Jian Ji, Hao Chen
Bacterial infections and biofilm formation on the surface of implants is an important issue which greatly affect biomedical applications and even cause device failure. Construction of high drug loading systems on the surface and control the drug release on-demand is an efficient way to lower the development of resistant bacteria and biofilm formation. In the present study, (montmorillonite/hyaluronic acid-gentamicin)10 ((MMT/HA-GS)10) organic/inorganic hybrid multilayer films were alternately self-assembled on substrates...
November 30, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/29184843/the-performance-implications-of-pharmacy-information-system-at-the-university-teaching-hospitals-of-shiraz-iran-cluster-approach
#7
Saeede Bayati, Peivand Bastani, Zahra Mahmoodzade Sagheb, Sara Jamalabadi, Mahnaz Samadbeik
Pharmacy information system (PIS) is becoming vital in assisting pharmacists to do their responsibilities. The aim of this study was to identify the current PIS implications in teaching hospitals affiliated with Shiraz University of Medical Science. This cross-sectional study was conducted in teaching hospitals affiliated with Shiraz University of Medical Science over the year 2016. Data were collected by observing the PIS as well as interviewing its users based on the researcher-made checklist. The checklist was prepared based on reviewing the Persian and English literature and its content validity was approved by the experts...
October 2017: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/29183858/qr-encoded-smart-oral-dosage-forms-by-inkjet-printing
#8
Magnus Edinger, Daniel Bar-Shalom, Niklas Sandler, Jukka Rantanen, Natalja Genina
The use of inkjet printing (IJP) technology enables the flexible manufacturing of personalized medicine with the doses tailored for each patient. In this study we demonstrate, for the first time, the applicability of IJP in the production of edible dosage forms in the pattern of a quick response (QR) code. This printed pattern contains the drug itself and encoded information relevant to the patient and/or healthcare professionals. IJP of active pharmaceutical ingredient (API)-containing ink in the pattern of QR code was performed onto a newly developed porous and flexible, but mechanically stable substrate with a good absorption capacity...
November 25, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29182337/ph-driven-reversible-self-assembly-of-micron-scale-dna-scaffolds
#9
Leopold N Green, Alessia Amodio, Hari K K Subramanian, Francesco Ricci, Elisa Franco
Inspired by cytoskeletal scaffolds that sense and respond dynamically to environmental changes and chemical inputs with a unique capacity for reconfiguration, we propose a strategy that allows the dynamic and reversible control of the growth and breakage of micron-scale synthetic DNA structures upon pH changes. We do so by rationally designing a pH-responsive system composed of synthetic DNA strands that act as pH sensors, regulators, and structural elements. Sensor strands can dynamically respond to pH changes and route regulatory strands to direct the self-assembly of structural elements into tubular structures...
November 28, 2017: Nano Letters
https://www.readbyqxmd.com/read/29180632/microfluidic-assisted-formation-of-highly-monodisperse-and-mesoporous-silica-soft-microcapsules
#10
Nizar Bchellaoui, Zain Hayat, Mohamed Mami, Rachida Dorbez-Sridi, Abdel Illah El Abed
The fabrication of mesoporous silica microcapsules with a highly controlled particle size ranging in the micrometer size presents a major challenge in many academic and industrial research areas, such as for the developement of smart drug delivery systems with a well controlled loading and release of (bio)active molecules. Many studies based on the solvent evaporation or solvent diffusion methods have been developed during the last two decades in order to control the particle size, which is often found to range at a sub-micrometer scale...
November 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29176623/microneedle-array-patches-loaded-with-dual-mineralized-protein-peptide-particles-for-type-2-diabetes-therapy
#11
Wei Chen, Rui Tian, Can Xu, Bryant C Yung, Guohao Wang, Yijing Liu, Qianqian Ni, Fuwu Zhang, Zijian Zhou, Jingjing Wang, Gang Niu, Ying Ma, Liwu Fu, Xiaoyuan Chen
The delivery of therapeutic peptides for diabetes therapy is compromised by short half-lives of drugs with the consequent need for multiple daily injections that reduce patient compliance and increase treatment cost. In this study, we demonstrate a smart exendin-4 (Ex4) delivery device based on microneedle (MN)-array patches integrated with dual mineralized particles separately containing Ex4 and glucose oxidase (GOx). The dual mineralized particle-based system can specifically release Ex4 while immobilizing GOx as a result of the differential response to the microenvironment induced by biological stimuli...
November 24, 2017: Nature Communications
https://www.readbyqxmd.com/read/29172119/assembling-particle-clusters-with-incoherent-3d-magnetic-fields
#12
Rasam Soheilian, Hamed Abdi, Craig E Maloney, Randall M Erb
Directed assembly of particle suspensions in massively parallel formats, such as with magnetic fields, has application in rheological control, smart drug delivery, and active colloidal devices from optical materials to microfluidics. At the heart of these applications lies a control optimization problem for driving the assembly and dissolution of highly monodisperse particle clusters. For magnetic field control, most attention to-date has been centered around in-phase coherent magnetic fields. Instead, we investigate a family of incoherent 3D magnetic fields that are capable of creating controlled and tunable particle assemblies such as dimers, trimers, and quadramers...
November 13, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29171371/-safe-medication-administration-in-hospitals
#13
W van der Veen, K Taxis, P M L A van den Bemt
- Every day medication is administered to thousands of hospital inpatients, and medication administration errors can occur.- Interventions to reduce medication administration errors have been developed and tested; these include training, double-checking procedures, and technological solutions (such as smart infusion pumps and barcode-controlled drug administration).- Most of the studies that investigated these interventions were small, meaning it is unclear which intervention is the most effective. More research is needed to identify the best solutions...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29168850/a-tellurylsulfide-bond-containing-redox-responsive-superparamagnetic-nanogel-with-acid-responsiveness-for-efficient-anticancer-therapy
#14
Xiaoyang Xia, Xia Xiang, Fenghong Huang, Zhen Zhang, Ling Han
A tellurylsulfide bond-containing biopolymer nanogel was first fabricated to achieve smart drug release. The reductive nanogel exhibited highly sensitive reduction-responsiveness, fast internalization, and efficient anticancer therapy. This approach displays a new potential of tellurylsulfide bond-containing nanocarriers for drug delivery.
November 23, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29154878/nanogel-based-natural-polymers-as-smart-carriers-for-the-controlled-delivery-of-timolol-maleate-through-the-cornea-for-glaucoma
#15
Roya Ilka, Mojdeh Mohseni, Mehran Kianirad, Masood Naseripour, Khadijeh Ashtari, Bita Mehravi
Despite frequent scientific efforts, efficient ocular drug delivery is a major challenge for pharmaceutical scientists. Poor bioavailability of ophthalmic solutions can be overcome by using smart ophthalmic drug-delivery systems. In this research, loading and delivery of Timolol Maleate (TM) through the cornea by synthesized nanoparticles based on biopolymers (chitosan-alginate) were studied. The physico-chemical properties of these nanoparticles were characterized using scanning electron microscopy (SEM), transmission electron microscopy (TEM) and dynamic light scattering (DLS)...
November 14, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29147499/nano-microvehicles-for-efficient-delivery-and-bio-sensing-at-the-cellular-level
#16
S Campuzano, B Esteban-Fernández de Ávila, P Yáñez-Sedeño, J M Pingarrón, J Wang
A perspective review of recent strategies involving the use of nano/microvehicles to address the key challenges associated with delivery and (bio)sensing at the cellular level is presented. The main types and characteristics of the different nano/microvehicles used for these cellular applications are discussed, including fabrication pathways, propulsion (catalytic, magnetic, acoustic or biological) and navigation strategies, and relevant parameters affecting their propulsion performance and sensing and delivery capabilities...
October 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29144411/nucleic-acid-aptamers-emerging-applications-in-medical-imaging-nanotechnology-neurosciences-and-drug-delivery
#17
REVIEW
Pascal Röthlisberger, Cécile Gasse, Marcel Hollenstein
Recent progresses in organic chemistry and molecular biology have allowed the emergence of numerous new applications of nucleic acids that markedly deviate from their natural functions. Particularly, DNA and RNA molecules-coined aptamers-can be brought to bind to specific targets with high affinity and selectivity. While aptamers are mainly applied as biosensors, diagnostic agents, tools in proteomics and biotechnology, and as targeted therapeutics, these chemical antibodies slowly begin to be used in other fields...
November 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29136373/photocontrol-of-antibacterial-activity-shifting-from-uv-to-red-light-activation
#18
Michael Wegener, Mickel J Hansen, Arnold J M Driessen, Wiktor Szymanski, Ben L Feringa
The field of photopharmacology aims to introduce smart drugs that, through the incorporation of molecular photoswitches, allow for the remote spatial and temporal control of bioactivity by light. This concept could be particularly beneficial in the treatment of bacterial infections, by reducing the systemic and environmental side-effects of antibiotics. A major concern in the realization of such light-responsive drugs is the wavelength of the light that is applied. Studies on the photocontrol of biologically active agents mostly rely on UV light, which is cytotoxic and poorly suited for tissue penetration...
November 14, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29132238/nanomicelle-drug-with-acid-triggered-doxorubicin-release-and-enhanced-cellular-uptake-ability-based-on-mpeg-graft-poly-n-2-aminoethyl-l-aspartamide-hexahydrophthalic-acid-copolymers
#19
Li Cao, Yi Xiao, Wei Lu, Shiyuan Liu, Lin Gan, Jiahui Yu, Jin Huang
In order to achieve the passive tumor targeting and acid-triggered drugs release in lysosomes, optimized delivery system for doxorubicin based on pH-sensitive complex nanomicelles with suitable particle size was developed in this research. Particularly, poly(L-succinimide) was thoroughly ring-opened by ethylenediamine to give the poly(N-(2-aminoethyl)-L-aspartamide). Then, graft copolymer mPEG-graft-poly(N-(2-aminoethyl)-L-aspartamide)-hexahydrophthalic acid (mPEG-g-P(ae-Asp)-Hap) was synthesized by grafting mPEG-2000 and hexahydrophthalic anhydride onto poly(N-(2-aminoethyl)-L-aspartamide)...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/29130888/co-delivery-of-cisplatin-and-cjm-126-via-photothermal-conversion-nanoparticles-for-enhanced-synergistic-antitumor-efficacy
#20
Chaoqun You, Hongshuai Wu, Mingxin Wang, Zhiguo Gao, Xiangyang Zhang, Baiwang Sun
Polymeric biomaterials that can be smartly disassembled through the cleavage of the covalent bonds in a controllable method upon an environmental stimuli such as pH change, redox, special enzymes, temperature, ultrasound as well as light irradiation but otherwise are stable under physiological condition has attracted great attention in past decades. In our study, a novel NIR-responsive targeted binary-drug loaded nanoparticles encapsulating ICG dye was prepared as a new co-delivery and combined therapy vehicle...
November 13, 2017: Nanotechnology
keyword
keyword
84362
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"