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Smart drugs

M Usman Munir, Ayesha Ihsan, Yasra Sarwar, Sadia Zafar Bajwa, Khizra Bano, Bushra Tehseen, Neelam Zeb, Irshad Hussain, M Tayyab Ansari, Madiha Saeed, Juan Li, M Zubair Iqbal, Aiguo Wu, Waheed S Khan
We report the development of effective drug loaded nanocarriers to combat multidrug resistant infection especially in case of osteomyelitis. The hollow mesoporous hydroxyapatite nanoparticles (hmHANPs) and solid/non-hollow hydroxyapatite nanoparticles (sHANPs) were synthesized by core-shell and co-precipitation techniques respectively. High encapsulation of the drug (ciprofloxacin) was observed in hmHANPs as compared to sHANPs, which may be due to the hollow porous structure of hmHANPs. These nanoparticles were characterized by scanning electron microscope (FESEM), N2 adsorption/desorption, Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and Thermogravimetric analysis (TGA)...
April 17, 2018: International Journal of Pharmaceutics
Li Liu, Hadi Bakhshi, Shaohua Jiang, Holger Schmalz, Seema Agarwal
In this paper, preparation method and actuation properties of an innovative composite membrane composed of thermo- and pH-responsive poly(N-isopropylacrylamide-co-acrylic acid) fibers (average diameter ≈ 905 nm) embedded within a passive thermoplastic polyurethane (TPU) matrix at different angles with degree of alignment as high as 98% are presented. The composite membrane has a gradient of TPU along the thickness. It has the capability of temperature- and pH-dependent direction-, and size-controlled actuation in few minutes...
April 20, 2018: Macromolecular Rapid Communications
Hui Wang, Qianwang Chen, Shuiqin Zhou
Nanosized crosslinked polymer networks, named as nanogels, are playing an increasingly important role in a diverse range of applications by virtue of their porous structures, large surface area, good biocompatibility and responsiveness to internal and/or external chemico-physical stimuli. Recently, a variety of carbon nanomaterials, such as carbon quantum dots, graphene/graphene oxide nanosheets, fullerenes, carbon nanotubes, and nanodiamonds, have been embedded into responsive polymer nanogels, in order to integrate the unique electro-optical properties of carbon nanomaterials with the merits of nanogels into a single hybrid nanogel system for improvement of their applications in nanomedicine...
April 18, 2018: Chemical Society Reviews
Shuang Fu, Yue Zhang, Qiaoxian Huang, Shuwen Guan, Ruibing Wang, Mingsong Zang, Ruizhen Tian, Shanpeng Qiao, Xin Zhang, Shengda Liu, Xiaotong Fan, Xiumei Li, Quan Luo, Chunxi Hou, Jiayun Xu, Zeyuan Dong, Junqiu Liu
Herein, a new reductive-responsive pillar[5]arene-based single-molecule layer polymer nanocapsules are constructed for drug delivery. The functionalized system shows good biocompatibility, efficient internalization into targeted cells and obvious triggered release of entrapped drugs in a reducing environment such as cytoplasm. Besides, this smart vehicle loaded with anticancer drug shows excellent inhibition for tumor cell proliferation and exhibits low side effect on normal cells. This work not only demonstrates the development of a new reductive-responsive single molecular layer polymer nanocapsule for anticancer drug targeting delivery, but also extends the design of smart materials for biomedical applications...
April 17, 2018: ACS Applied Materials & Interfaces
A Jain, S K Jain
Cancer remains a deadly disease for effective treatment. Although anomalous tumor microenvironment is now widely exploited for targeted chemotherapy, safe and efficacious drug delivery to tumor cells is not still warranted. Liposomes are promising biodegradable and biocompatible nanocarriers having potential amenability for surface and internal modifications, and extraordinary capability to carry both hydrophilic as well as hydrophobhic drugs. Meticulous fabrication of liposomes with tumor selective ligand(s) and PEGylation reduces immunogenicity and increase target-specificity...
April 15, 2018: Current Molecular Medicine
Brahma N Singh, Braj R Singh, Vijai K Gupta, Ravindra N Kharwar, Lorenzo Pecoraro
Microbial hydrophobin (MH)-based surface coating is emerging as a novel protein engineering approach for drug nanoparticles to enhance the solubility and stability of therapeutic agents. These hydrophobins are amphiphilic proteins that can form self-assembled monolayers on hydrophobic materials and can coat nanoparticles for efficient drug delivery.
April 11, 2018: Trends in Biotechnology
Ayomi Sheamilka Perera, Siqi Zhang, Shervanthi Homer-Vanniasinkam, Marc-Olivier Coppens, Mohan Edirisinghe
An efficient method is reported, for fabrication of composite microfibers that can be magnetically actuated and are biocompatible, targeting controlled drug release. Aqueous solutions of polyvinyl alcohol (PVA), incorporated with citric acid coated Fe3O4 magnetic nanoparticles (MNPs), are subject to infusion gyration, to generate 100-300 nm diameter composite fibers, with controllable MNP loading. The fibers are stable in polar solvents, such as ethanol, and do not show any leaching of MNPs for over 4 weeks...
April 12, 2018: ACS Applied Materials & Interfaces
Lucille Babel, Laure Guénée, Céline Besnard, Svetlana V Eliseeva, Stéphane Petoud, Claude Piguet
Metal-containing (bio)organic polymers are materials of continuously increasing importance for applications in energy storage and conversion, drug delivery, shape-memory items, supported catalysts, organic conductors and smart photonic devices. The embodiment of luminescent components provides a revolution in lighting and signaling with the ever-increasing development of polymeric light-emitting devices. Despite the unique properties expected from the introduction of optically and magnetically active lanthanides into organic polymers, the deficient control of the metal loading currently limits their design to empirical and poorly reproducible materials...
January 14, 2018: Chemical Science
Yangwei Deng, Jun Ling, Min-Hui Li
This paper reviews liposomes with crystalline phase and polymersomes exhibiting crystalline and thermotropic liquid crystalline phases in the membrane. Intriguing morphologies of vesicles are described, including spherical, ellipsoidal and faceted vesicles, produced by a large variety of amphiphilic molecules and polymers with nematic phase, smectic phase or crystalline phase. It is highlighted how the phase transitions and the phase grain boundaries could be used ingeniously to destabilize the vesicular structure and to achieve cargo-release under the action of external stimulation...
April 4, 2018: Nanoscale
Muhammad Sohail, Mudassir, Muhammad Usman Minhas, Shahzeb Khan, Zahid Hussain, Marcel de Matas, Syed Ahmed Shah, Samiullah Khan, Mubeen Kousar, Kaleem Ullah
Ulcerative colitis (UC) is an inflammatory disease of the colon that severely affects the quality of life of patients and usually responds well to anti-inflammatory agents for symptomatic relief; however, many patients need colectomy, a surgical procedure to remove whole or part of the colon. Though various types of pharmacological agents have been employed for the management of UC, the lack of effectiveness is usually predisposed to various reasons including lack of target-specific delivery of drugs and insufficient drug accumulation at the target site...
April 2, 2018: Drug Delivery and Translational Research
Bowen Ren, Xueyun Chen, Ye Ma, Shoukang Du, Saibo Qian, Yongjie Xu, Zhilin Yan, Jianliang Li, Yang Jia, Huaping Tan, Zhonghua Ling, Yong Chen, Xiaohong Hu
For practical adipose regeneration, the challenge is to dynamically deliver the key adipogenic insulin-like growth factors in hydrogels to induce adipogenesis. In order to achieve dynamic release, smart hydrogels to sense the change in the blood glucose concentration is required when glucose concentration increases. In this study, a heparin-based hydrogel has been developed for use in dynamic delivery of heparin nanospheres containing insulin-like growth factor. The gel scaffold was facilely prepared in physiological conditions by the formation of boronate-maltose ester cross-links between boronate and maltose groups of heparin derivatives...
April 3, 2018: Journal of Biomaterials Science. Polymer Edition
Kosuke Okeyoshi, Maiko K Okajima, Tatsuo Kaneko
 The geometric structures of soft materials can be controlled on the macro-scale using interfacial or mechanical instability, e.g., fingering patterns of viscous liquid and buckling patterns of gels during swelling/deswelling. These patterns can be used as smart materials for capturing/releasing and mass-transportation applications. Here we introduce the emergence of a uniaxially oriented membrane by drying an aqueous liquid-crystalline solution, composed of megamolecular supra-polysaccharides "sacran", from a limited space...
2018: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
Sarah E Zemore, Camillia Lui, Amy Mericle, Jordana Hemberg, Lee Ann Kaskutas
BACKGROUND: Despite the effectiveness of 12-step groups, most people reporting a prior alcohol use disorder (AUD) do not sustain involvement in such groups at beneficial levels. This highlights the need for research on other mutual help groups that address alcohol problems and may attract those who avoid 12-step groups. The current study addresses this need, offering outcome data from the first longitudinal, comparative study of 12-step groups and their alternatives: The Peer ALlternatives for Addiction (PAL) Study...
May 2018: Journal of Substance Abuse Treatment
Hua Jin, Mo Sun, Leilei Shi, Xinyuan Zhu, Wei Huang, Deyue Yan
As one of the promising prodrug strategies, amphiphilic polymeric prodrugs can be constructed by conjugating some small molecular hydrophobic anticancer drugs onto a hydrophilic biodegradable and biocompatible polymer, which further self-assembles into nanoparticles with controllable drug loading. Here, a biocompatible and biodegradable polyphosphoester and a broad-spectrum anticancer drug camptothecin (CPT) were selected as model compounds. We first designed and synthesized a novel cyclic phosphoester monomer (CPTSP) containing a disulfide bond linker and CPT as a side group...
March 29, 2018: Biomaterials Science
Kai Jiang, Ting Chi, Tao Li, Guirong Zheng, Lulu Fan, Yajun Liu, Xiufen Chen, Sijia Chen, Lee Jia, Jing-Wei Shao
Correction for 'A smart pH-responsive nano-carrier as a drug delivery system for the targeted delivery of ursolic acid: suppresses cancer growth and metastasis by modulating P53/MMP-9/PTEN/CD44 mediated multiple signaling pathways' by Kai Jiang et al., Nanoscale, 2017, 9, 9428-9439.
March 29, 2018: Nanoscale
Wei Jiang Goh, Shui Zou, Bertrand Czarny, Giorgia Pastorin
A hybrid drug delivery platform involving the fusion of cell membranes from U937 monocytes and synthetic lipids to create nano-cell vesicle technology systems (nCVTs) is designed. nCVTs are engineered for a targeted approach towards tumour sites by preserving key surface proteins from U937 monocytes, while being amendable to functionalization and loading due to their liposomal components.
March 29, 2018: Nanoscale
Dedeepya Uppalapati, Manisha Sharma, Zaid Aqrawe, Frazer Coutinho, Ilva D Rupenthal, Ben J Boyd, Jadranka Travas-Sejdic, Darren Svirskis
Conducting polymers such as polypyrrole (PPy) can be used as electrically responsive drug delivery systems typically prepared by electrochemical polymerisation, however, the amount of drug that can be delivered is typically low. To increase drug delivery capacity and prepare larger amounts of polymer, PPy nanoparticles were produced by chemical polymerisation over drug-loaded micelles. Two forms of dexamethasone were included to increase total drug loading and to explore the mechanisms of loading and release...
March 23, 2018: International Journal of Pharmaceutics
Ying Du, Wei Yan, Hua Lian, Chenyang Xiang, Lijie Duan, Chunsheng Xiao
In this work, a new kind of polyion complex (PIC) micelles with pH and reduction dual responsiveness was developed for effective intracellular drug delivery. The PIC micelles can be readily prepared by mixing a polycationic block polymer, methoxy poly(ethylene glycol)-b-poly(l-lysine) (mPEG-PLL), with a small molecule polyacid, 2, 2'-dithiodisuccinic acid (DTS) in aqueous media. The resultant PIC micelles are of uniform spherical shapes with hydrodynamic radii ranging from 65 to 75 nm based on different feeding ratios of mPEG-PLL and DTS...
March 15, 2018: Journal of Colloid and Interface Science
Sandeep Urandur, Venkatesh Teja Banala, Ravi Prakash Shukla, Naresh Mittapelly, Gitu Pandey, Navodayam Kalleti, Kalyan Mitra, Srikanta Kumar Rath, Ritu Trivedi, Pratibha Ramarao, Prabhat Ranjan Mishra
The prospective design of nanocarriers for personalized oncotherapy should be an ensemble of targeting, imaging, and noninvasive therapeutic capabilities. Here in, we report the development of the inverse hexagonal nano liquid crystalline (NLC) particles able to host Formononetin (FMN), a phytoestrogen with known anticancer activity and Tetraphenylethene (TPE), an iconic optical beacon with aggregation-induced-emission (AIE) signature simultaneously. Ordered 3D mesoporous internal structure and high lipid volume fraction of NLC nanoparticles (NLC NPs) frame the outer compartment for the better settlement of payloads...
March 26, 2018: ACS Applied Materials & Interfaces
Li Zhang, Ho Pan Bei, Yun Piao, Yufeng Wang, Mo Yang, Xin Zhao
Mesoporous silica nanoparticles (MSNs) have been demonstrated to be one of the most promising drug delivery systems (DDSs) to transport a variety of drug/biomolecules. Functionalization of MSN surfaces with responsive polymer brushes endows them with intelligent and controllable drug delivery properties, i.e., the encapsulated drugs/biomolecules will only be released upon certain stimuli including pH, temperature variation, light irradiation, enzyme, ultrasound, or redox potential, thus maximizing their therapeutic efficiency and minimizing side effects...
March 24, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
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