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Smart drugs

Kelly Smart, Sylvia M L Cox, Atsuko Nagano-Saito, Pedro Rosa-Neto, Marco Leyton, Chawki Benkelfat
BACKGROUND: [11 C]ABP688 is a positron emission tomography (PET) radioligand that binds selectively to metabotropic glutamate type 5 receptors (mGluR5). The use of this tracer has identified receptor binding changes in clinical populations, and has been informative in drug occupancy studies. However, previous studies have found significant increases in [11 C]ABP688 binding in the later scan of same-day comparisons, and estimates of test-retest reliability under consistent scanning conditions are not available...
June 23, 2018: Synapse
Farnaz Behroozi, Mohammad-Jafar Abdkhodaie, Hamid Sadeghi Abandansari, Leila Satarian, Mohammad Molazem, Khuloud T Al-Jamal, Hossein Baharvand
The oxidation-reduction (redox)-responsive micelle system is based on a diselenide-containing triblock copolymer, poly(ε-caprolactone)-bis(diselenide-methoxy poly(ethylene glycol)/poly(ethylene glycol)-folate) [PCL-(SeSe-mPEG/PEG-FA)2 ]. This has helped in the development of tumor-targeted delivery for hydrophobic anticancer drugs. The diselenide bond, as a redox-sensitive linkage, was designed in such a manner that it is located at the hydrophilic-hydrophobic hinge to allow complete collapse of the micelle and thus efficient drug release in redox environments...
June 18, 2018: Acta Biomaterialia
Hanna Maria Gabriella Barriga, Margaret Nancy Holme, Molly M Stevens
Cubosomes are highly stable nanoparticles formed from the lipid cubic phase and stabilized by a polymer based outer corona. Lipid cubic phases consist of a single lipid bilayer which forms a continuous periodic membrane lattice structure with pores formed by two interwoven water channels. Cubosome composition can be tuned to engineer pore sizes or include bioactive lipids, the polymer outer corona can be used for targeting and they are highly stable under physiological conditions. The structure provides a significantly higher membrane surface area for loading of membrane proteins and small drug molecules than liposomes...
June 21, 2018: Angewandte Chemie
Andrea Idili, Francesco Ricci
Triplex DNA is becoming a very useful domain to design pH-triggered DNA nanoswitches and nanodevices. The high versatility and programmability of triplex DNA interactions allows the integration of pH-controllable modules into DNA-based reactions and self-assembly processes. Here, we describe the procedure to characterize DNA-based triplex nanoswitches and more in general pH-triggered structure-switching mechanisms. Procedures to characterize pH-triggered DNA nanodevices will be useful for many applications in the field of biosensing, drug delivery systems and smart nanomaterials...
2018: Methods in Molecular Biology
Harald Breivik, Mads U Werner
No abstract text is available yet for this article.
December 29, 2017: Scandinavian Journal of Pain
Lubertus Bijlsma, Rubén Gil-Solsona, Félix Hernández, Juan Vicente Sancho
Synthetic cannabinoids (SCs) are consumed as legal alternative to cannabis and often allow passing drug-screening tests. Their rapid transience on the drug scene, combined with their mostly unknown metabolic profiles, creates a scenario with constantly moving analytical targets, making their monitoring and identification challenging. The development of fast screening strategies for SCs, not directly focused on their chemical structure, as an alternative to the commonly applied target acquisition methods, would be highly appreciated in forensic and public health laboratories...
June 16, 2018: Analytical and Bioanalytical Chemistry
Akram Firouzi-Amandi, Mehdi Dadashpour, Mohammad Nouri, Nosratollah Zarghami, Hamed Serati-Nouri, Davoud Jafari-Gharabaghlou, Bita Hazhir Karzar, Hassan Mellatyar, Leili Aghebati-Maleki, Zohreh Babaloo, Younes Pilehvar-Soltanahmadi
The purpose of this study was to investigate the efficiency of a natural flavonoid, Chrysin (Chr), encapsulated in PLGA-PEG nanoparticles (NPs) for the modulation of macrophage polarity from the pro-inflammatory M1 to anti-inflammatory M2 phenotype. The synthetized NPs were characterized using FTIR, DLS and FE-SEM. MTT assay was used to assess the toxicity of different concentration of Chr-encapsulated NPs on LPS/IFN-γ stimulated peritoneal exudate macrophages. To investigate the repolarization efficiency of Chr-encapsulated NPs, real-time PCR was applied to measure M1 (iNOS and SOCS3) and M2 (Arg1 and Fizz) markers expression...
June 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Zhaoxu Tu, Haishi Qiao, Yuting Yan, Guy Guday, Wei Chen, Mohsen Adeli, Rainer Haag
Multidrug resistance (MDR), which leads tumors resistance to traditional anticancer drugs, can cause the failure of chemotherapy treatments. In this work, we present a new way to overcome this problem using smart multifunctional graphene-based drug delivery systems which can target subcellular organelles and show synergistic hyperthermia and chemotherapy. Mitochondria-targeting ligands are conjugated onto the doxorubicin-loaded, polyglycerol-covered nanographene sheets to actively accumulate them inside the mitochondria after charge-mediated cellular internalization...
June 15, 2018: Angewandte Chemie
Jia Liu, Xingxin Liu, Ye Yuan, Qilin Li, Bingcheng Chang, Luming Xu, Bo Cai, Chao Qi, Cao Li, Xulin Jiang, Guobin Wang, Zheng Wang, Lin Wang
Since heterogeneity affects many functional aspects of a tumor, a way to overcome it is to arm nanosized drug delivery systems (nanoDDS) with diverse functions required to shatter heterogeneity. However, it remains technically challenging to fabricate a nanocarrier possessing all required functions. Here we propose a modular strategy for generating a supramolecular, multifunctional, stimuli-responsive nanoDDS through docking a parental core nanoDDS with various daughter function-prebuilt modules. Doxorubicin loaded mesoporous silica nanoparticles (MSNs) as the parental nano-core are wrapped by poly(β-cyclodextrin) (PCD) as a gatekeeper through host-guest interactions between cyclodextrin and pyridine groups of pyridine-disulfide bonds that confers pH/redox dual responsiveness, thus constructing stimuli-responsive nanoDDS (DOX@PRMSNs)...
June 12, 2018: ACS Applied Materials & Interfaces
Mahdi Rahimi, Vahid Shafiei-Irannejad, Kazem D Safa, Roya Salehi
A possible approach for clinical cancer treatment is combination chemotherapy. To address this issue, many anticancer agents have been used simultaneously to achieve synergistic effects with the different mechanism of actions, however, their toxic side effects are still a big challenge. In this study, a smart, biocompatible, magnetic nanocarrier composed of multi-branched ionic liquid-chitosan grafted mPEG was designed and used for targeted multidrug delivery of DOX and MTX as model anticancer agents to MCF7 breast cancer cells...
September 15, 2018: Carbohydrate Polymers
Okoh Adeyi Okoh, Philipp Klahn
Trimethyl lock (TML) systems are based on ortho-hydroxy dihydro cinnamic acid derivatives displaying an increased lactonization reactivity due to unfavorable steric interactions of three pendant methyl groups leading to the formation of hydro coumarins. Protection of the phenolic hydroxy function or masking of the reactivity as benzoquinone derivatives prevents lactonization and provides a trigger for controlled release of molecules attached to the carboxylic acid function via amides, esters or thioesters. Their easy synthesis and possible chemical adaption to several different triggers make TMLs a highly versatile module for the development of drug delivery systems, prodrug approaches, cell imaging tools, molecular tools for supramolecular chemistry as well as smart stimuli-responsive materials...
June 11, 2018: Chembiochem: a European Journal of Chemical Biology
Richard L Verrier
No abstract text is available yet for this article.
September 1, 2018: International Journal of Cardiology
Hamed Nosrati, Reza Abbasi, Jalil Charmi, Akram Rakhshbahar, Faezeh Aliakbarzadeh, Hossein Danafar, Soodabeh Davaran
This work described a folic acid conjugated delivery of chrysin-loaded bovine serum albumin nanoparticles, which could overcome the nonspecific targeting disadvantage. Chrysin (5, 7-dihydroxyflavone) is a natural flavonoid which have some significant biological effects on the processes of chemical defense. Chrysin loaded bovine serum albumin nanoparticles (Chrysin-BSA NPs) were synthesized by a simple desolvation procedure. Afterward, folic acid (FA) was conjugated to the surface of Chrysin-BSA NPs by carbodiimide chemistry (Chrysin-BSA-FA NPs)...
June 6, 2018: International Journal of Biological Macromolecules
Ping Wang, Larry J Kricka
BACKGROUND: Point-of-care technology (POCT)2 provides actionable information at the site of care to allow rapid clinical decision-making. With healthcare emphasis shifting toward precision medicine, population health, and chronic disease management, the potential impact of POCT continues to grow, and several prominent POCT trends have emerged or strengthened in the last decade. CONTENT: This review summarizes current and emerging trends in POCT, including technologies approved or cleared by the Food and Drug Administration or in development...
June 8, 2018: Clinical Chemistry
Parth K Shah, Jamie Irizarry, Sean O'Neill
Although smart infusion pumps are intended to prevent medication errors by alerting users about doses that exceed set thresholds, a large number of clinically insignificant alarms and alerts create the potential for alert and alarm fatigue. We searched the PubMed, Scopus, and Cumulative Index to Nursing and Allied Health Literature (CINAHL) databases for peer-reviewed literature (January 1, 2004-August 31, 2017) on managing smart pump alerts, alarms, and related fatigue. Twenty-nine articles that met the inclusion criteria were reviewed and organized into themes...
June 8, 2018: Pharmacotherapy
Xiao-Long Zhang, Ming Wu, Jiong Li, Shanyou Lan, Yongyi Zeng, Xiaolong Liu, Jingfeng Liu
The tumor hypoxia environment as well as the photodynamic therapy (PDT) induced hypoxia could severely limit the therapeutic efficacy of traditional PDT. Fortunately, the smart integration of hypoxia-responsive drug delivery system with PDT might be a promising strategy to enhance the PDT efficiency that hindered by hypoxia environment. Herein, a novel azobenzene (AZO) containing conjugated polymers (CPs) based nanocarrier (CPs-CPT-Ce6 NPs) was constructed for combination of PDT with chemotherapy, as well as to enhance the hypoxia-responsive drug release by light...
June 8, 2018: ACS Applied Materials & Interfaces
Gabriel Davis Jones, Alison Hitchcock, Frank Vajda, John Craig, Terence J O'Brien, Arjune Sen
Antiepileptic drugs (AEDs) are known to associate with an increased risk of major congenital malformations (MCMs) in children born to women who become pregnant while taking them. As the indications for AEDs continue to diversify, novel AEDs emerge, and polytherapy becomes more prevalent, the volume and complexity of the information relating to teratogenic risk can become unmanageable for the clinician. This in turn makes accurate education of pregnant women treated with AEDs regarding the risk of MCMs challenging...
June 2018: Epilepsia Open
Todd A Walroth, Shannon Smallwood, Karen Arthur, Betsy Vance, Alana Washington, Therese Staublin, Tammy Haslar, Jennifer G Reddan, James Fuller
PURPOSE: Development and implementation of an interprofessional consensus-driven process for review and optimization of smart-pump drug libraries and dosing limits are described. SUMMARY: The Indianapolis Coalition for Patient Safety (ICPS), which represents 6 Indianapolis-area health systems, identified an opportunity to reduce clinically insignificant alerts that smart infusion pumps present to end users. Through a consensus-driven process, ICPS aimed to identify best practices to implement at individual hospitals in order to establish specific action items for smart-pump drug library optimization...
June 15, 2018: American Journal of Health-system Pharmacy: AJHP
Sara Sario, Amélia M Silva, Isabel Gaivão
Titanium dioxide nanoparticles (TiO2 NP) are used in the food, drug, and cosmetics industries and evaluation of their human and environmental toxicity is required. We have tested the toxicity of TiO2 NP (anatase) with respect to developmental effects and DNA damage in Drosophila melanogaster strain Ok, using the eye-spot Somatic Mutation and Recombination Test (SMART) and the comet assay (neuroblasts). For the survival assay, TiO2 NP were supplied to adult flies for 72 h and no adverse effects were seen. TiO2 NP were supplied chronically for the prolificacy, SMART, and comet assays...
July 2018: Mutation Research
Sahika Inal, Jonathan Rivnay, Andreea-Otilia Suiu, George G Malliaras, Iain McCulloch
The emerging field of organic bioelectronics bridges the electronic world of organic-semiconductor-based devices with the soft, predominantly ionic world of biology. This crosstalk can occur in both directions. For example, a biochemical reaction may change the doping state of an organic material, generating an electronic readout. Conversely, an electronic signal from a device may stimulate a biological event. Cutting-edge research in this field results in the development of a broad variety of meaningful applications, from biosensors and drug delivery systems to health monitoring devices and brain-machine interfaces...
June 6, 2018: Accounts of Chemical Research
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