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https://www.readbyqxmd.com/read/28643173/immunotherapy-and-targeted-therapy-for-small-cell-lung-cancer-there-is-hope
#1
REVIEW
Jonathan M Lehman, Mary E Gwin, Pierre P Massion
Small cell lung cancer (SCLC) is a devastating and aggressive neuroendocrine carcinoma of the lung. It accounts for ~15% of lung cancer mortality and has had no improvement in standard treatment options for nearly 30 years. However, there is now hope for change with new therapies and modalities of therapy. Immunotherapies and checkpoint inhibitors are entering clinical practice, selected targeted therapies show promise, and "smart bomb"-based drug/radioconjugates have led to good response in early clinical trials...
July 2017: Current Oncology Reports
https://www.readbyqxmd.com/read/28633813/multi-stimuli-responsive-smart-chitosan-based-microcapsules-for-targeted-drug-delivery-and-triggered-drug-release
#2
Xuejun Cui, Xinyu Guan, Shuangling Zhong, Jie Chen, Houjuan Zhu, Zhanfeng Li, Fengzhi Xu, Peng Chen, Hongyan Wang
In the present study, we designed a novel, multi-stimuli responsive, biocompatible and non-immunogenic smart carrier for targeted delivery and triggered release of hydrophobic drugs. The designed multi-stimuli responsive smart chitosan-based microcapsules (MSRS-CS-MCs) have been fabricated successfully from folic acid (FA) functionalized thiolated chitosan via a facile sonochemical method. Targeting moiety FA and red fluorescent dye (Rhodamine B isothiocyanate, RITC) were immobilized onto the shells of microcapsules...
September 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28633591/approaches-in-topical-ocular-drug-delivery-and-developments-in-the-use-of-contact-lenses-as-drug-delivery-devices
#3
Prina Mehta, Rita Haj-Ahmad, Ali Al-Kinani, Muhammad Sohail Arshad, Ming-Wei Chang, Raid G Alany, Zeeshan Ahmad
Drug-delivery approaches have diversified over the last two decades with the emergence of nanotechnologies, smart polymeric systems and multimodal functionalities. The intended target for specific treatment of disease is the key defining developing parameter. One such area which has undergone significant advancements relates to ocular delivery. This has been expedited by the development of material advancement, mechanistic concepts and through the deployment of advanced process technologies. This review will focus on the developments within lens-based drug delivery while touching on conventional and current methods of topical ocular drug delivery...
July 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28632268/ball-in-ball-zro2-nanostructure-for-simultaneous-ct-imaging-and-highly-efficient-synergic-microwave-ablation-and-tri-stimuli-responsive-chemotherapy-of-tumors
#4
Dan Long, Meng Niu, Longfei Tan, Changhui Fu, Xiangling Ren, Ke Xu, Hongshan Zhong, Jingzhuo Wang, Laifeng Li, Xianwei Meng
Combined thermo-chemotherapy displays outstanding synergically therapeutic efficiency when compared with standalone thermotherapy and chemotherapy. Herein, we developed a smart tri-stimuli-responsive drug delivery system involving X@BB-ZrO2 NPs (X represents loaded IL, DOX, keratin and tetradecanol) based on novel ball-in-ball-structured ZrO2 nanoparticles (BB-ZrO2 NPs). The microwave energy conversion efficiency of BB-ZrO2 NPs was 41.2% higher than that of traditional single-layer NPs due to the cooperative action of self-reflection and spatial confinement effect of the special two-layer hollow nanostructure...
June 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28628997/preparations-of-hyperbranched-polymer-nano-micelles-and-the-ph-redox-controlled-drug-release-behaviors
#5
Liping Zhang, Yamin Zhou, Gang Shi, Xinxin Sang, Caihua Ni
Hyperbranched polymer nano micelles (NMs) were prepared through a nucleophilic ring opening polymerization between cystamine and polyethylene glycol diglycidyl ether, followed by a reaction of amino groups and dimethyl maleic anhydride. The NMs showed spheric morphologies with hydrodynamic diameters of 106-120nm. Doxorubicin was loaded in the NMs with loading rate as high as 15.38wt%; The NMs possessed negative zeta potentials in aqueous solutions of pH7.4 due to the carboxyl ions on the particle surfaces, but the zeta potentials were converted to positive ones due to the hydrolysis of amide bonds at pH5...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28625062/bioinspired-hand-operating-smart-wetting-systems-using-smooth-liquid-coatings
#6
Mizuki Tenjimbayashi, Takeshi Matsubayashi, Takeo Moriya, Seimei Shiratori
Manually controllable 'hand-operating' smart systems have been developed in many fields, including smart wetting materials, electronic devices, molecular machines, and drug delivery systems. Because complex morphological or chemical control are generally required, versatile strategies for constructing the system are technologically important. Inspired by the natural phenomenon of raindrops rarely bouncing and usually spreading on a puddle, we introduce a droplet-impact-triggering smart-wetting system using "non-smart" smooth liquid coating materials...
June 19, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28620888/design-of-isoniazid-smart-nanogel-by-gamma-radiation-induced-template-polymerization-for-biomedical-application
#7
Samia M Omar, Nabila A Maziad, Nourhan M El-Tantawy
PURPOSE: Preparation of Isoniazid (INH) loaded nanogel particles using gamma radiation as safe, simple, cheap and reproducible technique for promoting mycobacterial killing in a lower-dose system aiming in developing of drug resistance. METHODS: Polymeric pH-sensitive nanogels were prepared by gamma radiation-induced polymerization of Acrylic acid (AAc) or Itaconic acid (IA), in aqueous solution of polyvinylpyrrolidone (PVP), as template polymer. The prepared nanogels were utilized for encapsulation of INH...
June 15, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28616966/magnetic-resonance-imaging-guided-multi-drug-chemotherapy-and-photothermal-synergistic-therapy-with-ph-and-nir-stimulation-release
#8
Jichun Yang, Yang Chen, Yu-Hao Li, Xue-Bo Yin
The combination of multi-drug chemotherapy and photothermal therapy (PTT) enhances cancer therapeutic efficacy. Herein, we develop a simple and smart pH/NIR dual-stimulus-responsive degradable mesoporous CoFe2O4@PDA@ZIF-8 sandwich nanocomposite. Mesoporous CoFe2O4 core acts as T2-weighted magnetic resonance (MR) imaging probe, PTT agent, and loading platform of hydrophilic doxorubicin (DOX). A polydopamine (PDA) layer is used to avoid the premature leakage of DOX before arriving at tumor site, enhance PTT efficiency, and facilitate the integration of ZIF-8 (a kind of metal-organic frameworks)...
June 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28611459/smart-ph-sensitive-nanoassemblies-with-cleavable-pegylation-for-tumor-targeted-drug-delivery
#9
Guanren Zhao, Ling Long, Lina Zhang, Mingli Peng, Ting Cui, Xiaoxun Wen, Xing Zhou, Lijun Sun, Ling Che
A new acidly sensitive PEGylated polyethylenimine linked by Schiff base (PEG-s-PEI) was designed to render pH-sensitive PEGylation nanoassemblies through multiple interactions with indomethacin and docetaxel (DTX). DTX nanoassemblies driven by PEG-s-PEI thus formulated exhibited an excellent pH-sensitivity PEGylation cleavage performance at extracellular pH of tumor microenvironment, compared to normal tissues, thereby long circulated in blood but were highly phagocytosed by tumor cells. Consequently, this smart pH-sensitive PEGylation cleavage provided an efficient strategy to target tumor microenvironment, in turn afforded superior therapeutic outcome in anti-tumor activity...
June 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28608630/precisely-tailored-dna-nanostructures-and-their-theranostic-applications
#10
REVIEW
Bing Zhu, Lihua Wang, Jiang Li, Chunhai Fan
A critical challenge in nanotechnology is the limited precision and controllability of the structural parameters, which brings about concerns in uniformity, reproducibility and performance. Self-assembled DNA nanostructures, as a newly emerged type of nano-biomaterials, possess low-nanometer precision, excellent programmability and addressability. They can precisely arrange various molecules and materials to form spatially ordered complex, resulting in unambiguous physical or chemical properties. Because of these, DNA nanostructures have shown great promise in numerous biomedical theranostic applications...
June 13, 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/28602505/proposal-of-5-methoxy-n-methyl-n-isopropyltryptamine-consumption-biomarkers-through-identification-of-in-vivo-metabolites-from-mice
#11
D Fabregat-Safont, M Barneo-Muñoz, F Martinez-Garcia, J V Sancho, F Hernández, M Ibáñez
New psychoactive substances (NPS) are a new breed of synthetically produced substances designed to mimic the effects of traditional illegal drugs. Synthetic cannabinoids and synthetic cathinones are the two most common groups, which try to mimic the effects of the natural compounds (9)Δ-tetrahydrocannabinol and cathinone, respectively. Similarly, synthetic tryptamines are designer compounds which are based on the compounds psilocin, N,N-dimethyltryptamine and 5-methoxy-N,N-dimethyltryptamine found in some mushrooms...
June 5, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28597995/k-responsive-block-copolymer-micelles-for-targeted-intracellular-drug-delivery
#12
Shan Yan, Lin-Yan Wan, Xiao-Jie Ju, Jiang-Feng Wu, Lei Zhang, Ming Li, Zhuang Liu, Wei Wang, Rui Xie, Liang-Yin Chu
In this work, a novel type of block copolymer micelles with K(+) -responsive characteristics for targeted intracellular drug delivery is developed. The proposed smart micelles are prepared by self-assembly of poly(ethylene glycol)-b-poly(N-isopropylacry-lamide-co-benzo-18-crown-6-acrylamide) (PEG-b-P(NIPAM-co-B18C6Am)) block copolymers. Prednisolone acetate (PA) is successfully loaded into the micelles as the model drug, with loading content of 4.7 wt%. The PA-loaded micelles display a significantly boosted drug release in simulated intracellular fluid with a high K(+) concentration of 150 × 10(-3) m, as compared with that in simulated extracellular fluid...
June 9, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28596597/smart-microparticles-with-a-ph-responsive-macropore-for-targeted-oral-drug-delivery
#13
Ankit Kumar, Carlo Montemagno, Hyo-Jick Choi
The development of a smart microencapsulation system programmed to actively respond to environmental pH change has long been recognized a key technology in pharmaceutical and food sciences. To this end, we developed hollow microparticles (MPs) with self-controlled macropores that respond to environmental pH change, using an Oil-in-Water emulsion technique, for oral drug delivery. We observed that freeze-drying of MPs induced closure of macropores. The closing/opening behavior of macropores was confirmed by exposing MPs encapsulating different ingredients (sulforhodamine b, fluorescent nanoparticles, and lactase) to simulated gastrointestinal (GI) fluids...
June 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28587239/magnetic-lateral-flow-strip-for-the-detection-of-cocaine-in-urine-by-naked-eyes-and-smart-phone-camera
#14
Jing Wu, Mingling Dong, Cheng Zhang, Yu Wang, Mengxia Xie, Yiping Chen
Magnetic lateral flow strip (MLFS) based on magnetic bead (MB) and smart phone camera has been developed for quantitative detection of cocaine (CC) in urine samples. CC and CC-bovine serum albumin (CC-BSA) could competitively react with MB-antibody (MB-Ab) of CC on the surface of test line of MLFS. The color of MB-Ab conjugate on the test line relates to the concentration of target in the competition immunoassay format, which can be used as a visual signal. Furthermore, the color density of the MB-Ab conjugate can be transferred into digital signal (gray value) by a smart phone, which can be used as a quantitative signal...
June 5, 2017: Sensors
https://www.readbyqxmd.com/read/28585970/mesoporous-silica-nanoparticles-in-injectable-hydrogels-factors-influencing-cellular-uptake-and-viability
#15
Bernhard Baumann, Rainer Wittig, Mika Lindén
The incorporation of nanoparticles as drug vectors into 3D scaffolds has attracted a lot of recent interest. In particular, tissue engineering applications would benefit from a spatially and temporally regulated release of biological cues, which act on precursor/stem cells in a three-dimensional growth environment. Injectable cell- and nanoparticle-containing scaffolds are especially interesting in this respect, but require matrix self-assembly and coordinated interactions between cells, matrices, and nanoparticles, which are largely uncharacterized yet...
June 6, 2017: Nanoscale
https://www.readbyqxmd.com/read/28583902/ph-responsive-self-healing-injectable-hydrogel-based-on-n-carboxyethyl-chitosan-for-hepatocellular-carcinoma-therapy
#16
Jin Qu, Xin Zhao, Peter X Ma, Baolin Guo
Injectable hydrogels with pH-responsiveness and self-healing ability have great potential for anti-cancer drug delivery. Herein, we developed a series of polysaccharide-based self-healing hydrogels with pH-sensitivity as drug delivery vehicles for hepatocellular carcinoma therapy. The hydrogels were prepared by using N-carboxyethyl chitosan (CEC) synthesized via Michael reaction in aqueous solution and dibenzaldehyde-terminated poly(ethylene glycol) (PEGDA). Doxorubicin (Dox), as a model of water-soluble small molecule anti-cancer drug was encapsulated into the hydrogel in situ...
June 2, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28583900/ph-responsive-unimolecular-micelle-gold-nanoparticles-drug-nanohybrid-system-for-cancer-theranostics
#17
Wenjing Lin, Na Yao, Long Qian, Xiaofang Zhang, Quan Chen, Jufang Wang, Lijuan Zhang
The development of an in situ formed pH-responsive theranostic nanocomposite for anticancer drug delivery and computed tomography (CT) imaging was reported. β-cyclodextrin-{poly(lactide)-poly(2-(dimethylamino) ethyl methacrylate)-poly[oligo(2-ethyl-2-oxazoline)methacrylate]}21 [β-CD-(PLA-PDMAEMA-PEtOxMA)21] unimolecular micelles served as a template for the in situ formation of gold nanoparticles (GNPs) and the subsequent encapsulation of doxorubicin (DOX). The formation of unimolecular micelles, microstructures and the distributions of GNPs and DOX were investigated through the combination of experiments and dissipative particle dynamics (DPD) simulations...
June 3, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28583429/towards-the-virtual-human-patient-quantitative-systems-pharmacology-in-alzheimer-s-disease
#18
Hugo Geerts, Athan Spiros, Patrick Roberts, Robert Carr
Development of successful therapeutic interventions in Central Nervous Systems (CNS) disorders is a daunting challenge with a low success rate. Probable reasons include the lack of translation from preclinical animal models, the individual variability of many pathological processes converging upon the same clinical phenotype, the pharmacodynamical interaction of various comedications and last but not least the complexity of the human brain. This paper argues for a re-engineering of the pharmaceutical CNS Research & Development strategy using ideas focused on advanced computer modeling and simulation from adjacent engineering-based industries...
June 2, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28582603/stimuli-responsive-shape-transforming-nanostructured-particles
#19
Junhyuk Lee, Kang Hee Ku, Mingoo Kim, Jae Man Shin, Junghun Han, Chan Ho Park, Gi-Ra Yi, Se Gyu Jang, Bumjoon J Kim
Development of particles that change shape in response to external stimuli has been a long-thought goal for producing bioinspired, smart materials. Herein, the temperature-driven transformation of the shape and morphology of polymer particles composed of polystyrene-b-poly(4-vinylpyridine) (PS-b-P4VP) block copolymers (BCPs) and temperature-responsive poly(N-isopropylacrylamide) (PNIPAM) surfactants is reported. PNIPAM acts as a temperature-responsive surfactant with two important roles. First, PNIPAM stabilizes oil-in-water droplets as a P4VP-selective surfactant, creating a nearly neutral interface between the PS and P4VP domains together with cetyltrimethylammonium bromide, a PS-selective surfactant, to form anisotropic PS-b-P4VP particles (i...
June 5, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28581834/updates-on-smart-polymeric-carrier-systems-for-protein-delivery
#20
Ibrahim El-Sherbiny, Islam Khalil, Isra Ali, Magdi Yacoub
Smart materials are those materials that are responsive to chemical (organic molecules, chemical agents or specific agents), biochemical (protein, enzymes, growth factors, substrates or ligands), physical (electric field, magnetic field, temperature, pH, ionic strength or radiation) or mechanical (pressure or mechanical stress) signals. These responsive materials interact with the stimuli by changing their properties or conformational structures in a predictable manner. Recently, smart polymers have been utilized in various biomedical applications...
June 21, 2017: Drug Development and Industrial Pharmacy
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