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https://www.readbyqxmd.com/read/28821147/uv-crosslinkable-and-thermo-responsive-chitosan-hybrid-hydrogel-for-nir-triggered-localized-on-demand-drug-delivery
#1
Lei Wang, Baoqiang Li, Feng Xu, Zheheng Xu, Daqing Wei, Yujie Feng, Yaming Wang, Dechang Jia, Yu Zhou
Innovative drug delivery technologies based on smart hydrogels for localized on-demand drug delivery had aroused great interest. To acquire smart UV-crosslinkable chitosan hydrogel for NIR-triggered localized on-demanded drug release, a novel UV-crosslinkable and thermo-responsive chitosan was first designed and synthesized by grafting with poly N-isopropylacrylamide, acetylation of methacryloyl groups and embedding with photothermal carbon. The UV-crosslinkable unit (methacryloyl groups) endowed chitosan with gelation via UV irradiation...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28820072/structural-design-and-physicochemical-foundations-of-hydrogels-for-biomedical-and-pharmaceutical-applications
#2
Qingyong Li, Wen Li, Jie Xu, Zhengxiang Ning, Jiaoyan Ren, Wenzhen Liao
Biomedical research, known as medical research, is conducive to support and promote the development of knowledge in the field of medicine. Hydrogels have been extensively used in many biomedical fields due to theirs highly absorbent and flexible properties. The smart hydrogels, especially, can respond to a broad range of external stimuli such as temperature, pH value, light, electric and magnetic fields. With excellent biocompatibility, tunable rheology, mechanical properties, porosity, and hydrated molecular structure, hydrogels are considered as promising candidate for simulating local tissue microenvironment...
August 17, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28818724/enzyme-sensitive-smart-inulin-dehydropeptide-conjugate-self-assembles-into-nanostructures-useful-for-targeted-delivery-of-ornidazole
#3
Kriti Shivhare, Charu Garg, Ayushi Priyam, Alka Gupta, Ashwani Kumar Sharma, Pradeep Kumar
Molecular self-assembly of biodegradable amphiphilic polymers allows rational design of biocompatible nanomaterials for drug delivery. Use of substituted polysaccharides for such applications offers the ease of design and synthesis, and provides higher biofunctionality and biocompatibility to nanomaterials. The present work focuses on the synthesis, characterization and potential biomedical applications of self-assembled polysaccharide-based materials. We demonstrated that the synthesized amphiphilic inulin self-assembled in aqueous medium into nanostructures with average size in the range of 146-486nm and encapsulated hydrophobic therapeutic molecule, ornidazole...
August 14, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28813028/detection-methodologies-for-pathogen-and-toxins-a-review
#4
REVIEW
Md Eshrat E Alahi, Subhas Chandra Mukhopadhyay
Pathogen and toxin-contaminated foods and beverages are a major source of illnesses, even death, and have a significant economic impact worldwide. Human health is always under a potential threat, including from biological warfare, due to these dangerous pathogens. The agricultural and food production chain consists of many steps such as harvesting, handling, processing, packaging, storage, distribution, preparation, and consumption. Each step is susceptible to threats of environmental contamination or failure to safeguard the processes...
August 16, 2017: Sensors
https://www.readbyqxmd.com/read/28812999/synthesis-and-evaluation-of-a-sodium-alginate-4-aminosalicylic-acid-based-microporous-hydrogel-for-potential-viscosupplementation-for-joint-injuries-and-arthritis-induced-conditions
#5
Dharmesh R Chejara, Mostafa Mabrouk, Pradeep Kumar, Yahya E Choonara, Pierre P D Kondiah, Ravindra V Badhe, Lisa C du Toit, Divya Bijukumar, Viness Pillay
A microporous hydrogel was developed using sodium alginate (alg) and 4-aminosalicylic acid (4-ASA). The synthesized hydrogel was characterized using various analytical techniques such as Fourier transform infrared spectroscopy (FTIR), Carbon-13 nuclear magnetic resonance ((13)C-NMR), X-ray powder diffraction (XRD), scanning electron microscopy (SEM), and differential scanning calorimetry (DSC). Additonal carboxyl and hydroxyl functional groups of 4-ASA provided significant lubrication and stress-triggered sol-gel transition to the conjugated hydrogel...
August 16, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28802202/a-thermosensitive-drug-delivery-system-prepared-by-blend-electrospinning
#6
Heyu Li, Kailin Liu, Qingqing Sang, Gareth R Williams, Junzi Wu, Haijun Wang, Jianrong Wu, Li-Min Zhu
In this study, the thermosensitive polymer poly(di(ethylene glycol) methyl ether methacrylate) (PDEGMA) was synthesized and electrospun into fibers by blending with ethyl cellulose (EC). Fibers were additionally prepared loaded with ketoprofen (KET) as a model drug. Smooth cylindrical fibers could generally be observed by electron microscopy, although there were some beads and fused fibers visible in the KET-loaded materials. KET was found to be amorphously distributed in the fibers on the basis of X-ray diffraction data...
July 25, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28801266/lipogels-responsive-to-near-infrared-light-for-the-triggered-release-of-therapeutic-agents
#7
Francisco Martín-Saavedra, Eduardo Ruiz-Hernández, Clara Escudero-Duch, Martin Prieto, Manuel Arruebo, Negar Sadeghi, Roel Deckers, Gert Storm, Wim E Hennink, Jesús Santamaría, Nuria Vilaboa
Here we report a composite system based on fibrin hydrogels that incorporate in their structure near-infrared (NIR) responsive nanomaterials and thermosensitive liposomes (TSL). Polymerized fibrin networks entrap simultaneously gold-based nanoparticles (NPs) capable of transducing NIR photon energy into heat, and lysolipid-incorporated TSL (LTSL) loaded with doxorubicin hydrochloride (DOX). NIR irradiation of the resulting hydrogels (referred to as "lipogels") with 808 nm laser light increased the temperature of the illuminated areas, leading to the release of the liposomal cargo...
August 8, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28796191/smart-carriers-and-nanohealers-a-nanomedical-insight-on-natural-polymers
#8
REVIEW
Sreejith Raveendran, Ankit K Rochani, Toru Maekawa, D Sakthi Kumar
Biodegradable polymers are popularly being used in an increasing number of fields in the past few decades. The popularity and favorability of these materials are due to their remarkable properties, enabling a wide range of applications and market requirements to be met. Polymer biodegradable systems are a promising arena of research for targeted and site-specific controlled drug delivery, for developing artificial limbs, 3D porous scaffolds for cellular regeneration or tissue engineering and biosensing applications...
August 10, 2017: Materials
https://www.readbyqxmd.com/read/28783443/a-new-style-for-synthesis-of-thermo-responsive-fe3o4-poly-methylmethacrylate-b-n-isopropylacrylamide-b-acrylic-acid-magnetic-composite-nanosphere-and-theranostic-applications
#9
Aliyeh Ghamkhari, Bakhshali Massoumi, Roya Salehi
In this work,a novelthermo-responsive Fe3O4/poly(methylmethacrylate-b-N-isopropylacrylamide-b-acrylic acid) magnetic composite nanospherewas synthesized for anticancer drug delivery applications. For this propose, the poly(methylmethacrylate-b-N-isopropylacrylamide-b-acrylicacid) [poly(MMA-b-NIPAAm-b-AAc)] was synthesizedviareversible addition-fragmentation transfer (RAFT)method.The physic-chemical characterization of the Fe3O4/poly(MMA-b-NIPAAm-b-AAc) magnetic composite nanosphere was investigated by FTIR, HNMRspectroscopies and GPC,FESEM, XRD, VSM andDLS...
August 7, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28780487/application-of-normal-fluorescence-and-stability-indicating-derivative-synchronous-fluorescence-spectroscopy-for-the-determination-of-gliquidone-in-presence-of-its-fluorescent-alkaline-degradation-product
#10
Mohamed R El-Ghobashy, Ali M Yehia, Aya H Helmy, Nadia F Youssef
Simple, smart and sensitive normal fluorescence and stability-indicating derivative synchronous spectrofluorimetric methods have been developed and validated for the determination of gliquidone in the drug substance and drug product. Normal spectrofluorimetric method of gliquidone was established in methanol at λ excitation 225nm and λ emission 400nm in concentration range 0.2-3μg/ml with LOD equal 0.028. The fluorescence quantum yield of gliquidone was calculated using quinine sulfate as a reference and found to be 0...
July 29, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28777535/electrospun-nanofibers-new-concepts-materials-and-applications
#11
Jiajia Xue, Jingwei Xie, Wenying Liu, Younan Xia
Electrospinning is a simple and versatile technique that relies on the electrostatic repulsion between surface charges to continuously draw nanofibers from a viscoelastic fluid. It has been applied to successfully produce nanofibers, with diameters down to tens of nanometers, from a rich variety of materials, including polymers, ceramics, small molecules, and their combinations. In addition to solid nanofibers with a smooth surface, electrospinning has also been adapted to generate nanofibers with a number of secondary structures, including those characterized by a porous, hollow, or core-sheath structure...
August 4, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28776612/overcoming-t-gondii-infection-and-intracellular-protein-nanocapsules-as-biomaterials-for-ultrasonically-controlled-drug-release
#12
REVIEW
M S Aw, L Paniwnyk
One of the pivotal matters of concern in intracellular drug delivery is the preparation of biomaterials containing drugs that are compatible with the host target. Nanocapsules for oral delivery are found to be suitable candidates for targeting Toxoplasma gondii (T. gondii), a maneuvering and smart protozoic parasite found across Europe and America that causes a subtle but deadly infection. To overcome this disease, there is much potential of integrating protein-based cells into bioinspired nanocompartments such as via biodegradable cross-linked disulfide polyelectrolyte nanoparticles...
August 4, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28766478/novel-approach-for-the-simultaneous-determination-of-carbinoxamine-maleate-pholcodine-and-ephedrine-hydrochloride-without-interference-from-coloring-matter-in-an-antitussive-preparation-using-smart-spectrophotometric-methods
#13
Azza A Moustafa, Maha A Hegazy, Dalia Mohamed, Omnia Ali
The presence of coloring matters in syrups usually interferes with the spectrophotometric determination of active pharmaceutical ingredients. A novel approach was introduced to eliminate the interference of sunset yellow (coloring matter) in Cyrinol syrup. Smart, simple, accurate, and selective spectrophotometric methods were developed and validated for the simultaneous determination of a ternary mixture of carbinoxamine maleate, pholcodine, and ephedrine hydrochloride in syrup. Four of the applied methods used ratio spectra: successive derivative subtraction coupled with constant multiplication, successive derivative of ratio spectra, ratio subtraction coupled with ratio difference, and ratio spectra continuous wavelet transforms zero-crossing...
August 1, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28763342/apparent-resistant-hypertension-and-the-risk-of-vascular-events-and-mortality-in-patients-with-manifest-vascular-disease
#14
Nicolette G C van der Sande, Esther de Beus, Michiel L Bots, Michiel Voskuil, Peter J Blankestijn, Frank Visseren, Wilko Spiering
OBJECTIVE: Patients with apparent resistant hypertension (aRH) are at increased risk for developing cardiovascular disease. It is unknown if this condition is related to increased cardiovascular risk in patients with clinically manifest vascular disease. METHODS: In 6191 hypertensive patients with clinically manifest vascular disease, we evaluated the risk of subsequent vascular events and mortality between patients with controlled hypertension, uncontrolled hypertension, controlled aRH, and uncontrolled aRH...
July 29, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28763074/nanodevices-that-acts-as-nanocarriers-for-controlled-and-directed-drug-delivery-to-select-cells-organs-or-tissues-in-cardiovascular-diseases
#15
Juan Manuel Vélez-Reséndiz, Juan Jesús Vélez-Arvízu
Cardiovascular disease, which today represents the main cause of death worldwide, is a likely candidate for the application of nanotechnology in the near future. Nanocarriers are currently being developed to deliver medicine (smart drugs) to selected targets in cells and tissues of blood vessels and the heart, as well as to aid in diagnosis and screening for early detection and individualized treatment. Other applications of nanotechnology hold promise for the long run, such as using nanodevices for drug delivery or correcting the misfolding of proteins...
May 2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/28758600/current-strategies-to-improve-the-target-of-cell-penetrating-peptides-used-for-antitumor-therapeutics
#16
Fang Zhang, Dandan Yang, Shanshan Jiang, Lei Wu, Li Qin, Huiyang He, Peng Zhang
Cell penetrating peptides (CPPs) equipped with a high penetrating ability are used as a promising tool to gain access to the cell interior, cross the cell membrane and deliver bioactive small or macromolecular cargos into the cytoplasm or nucleus. The superiority of wide range of applications, high transport efficiency and low biological toxicity make them particularly desirable in laboratory or clinical studies. Previous studies have shown that their non-selectivity and reaction with proteins in plasma hamper their application for tumor therapy, which might adversely affect the treatment effect and even induce some side effects...
July 27, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28756320/surface-tailoring-of-polyacrylate-grafted-graphene-oxide-for-controlled-interactions-at-the-biointerface
#17
Giuseppe Consiglio, Patrizia Di Pietro, Luisa D'Urso, Giuseppe Forte, Giuseppe Grasso, Carmelo Sgarlata, Damien Cossement, Rony Snyders, Cristina Satriano
The actual surface termination and lateral size of a nanomaterial is crucial in its interaction with biomolecules at the aqueous interface. Graphene oxide (GO) nanosheets have been demonstrated as promising nanoplatform for both diagnostic and therapeutic applications. To this respect, 'smart' GO nanocarriers have been obtained by the surface functionalisation with polymers sensitive, e.g., to pH, as the polyacrylate (PAA) case. In this work, hybrid GO/PAA samples prepared respectively at low (GOPAAthin) or high (GOPAAthick) monomer grafting ratio, were scrutinised both theoretically, by molecular dynamic calculations, and experimentally by a multitechnique approach, including spectroscopic (UV-visible, fluorescence, Raman, Attenuated-total reflectance-Fourier transformed infrared and X-ray photoelectron spectroscopies), spectrometric (time-of-flight secondary ion and electrospray ionisation mass spectrometries) and microscopic (atomic force and confocal microscopies) methods...
July 21, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28750341/the-enzyme-sensitive-release-of-prodigiosin-grafted-%C3%AE-cyclodextrin-and-chitosan-magnetic-nanoparticles-as-an-anticancer-drug-delivery-system-synthesis-characterization-and-cytotoxicity-studies
#18
Banafsheh Rastegari, Hamid Reza Karbalaei-Heidari, Sedigheh Zeinali, Heather Sheardown
In present investigation, two glucose based smart tumor-targeted drug delivery systems coupled with enzyme-sensitive release strategy are introduced. Magnetic nanoparticles (Fe3O4) were grafted with carboxymethyl chitosan (CS) and β-cyclodextrin (β-CD) as carriers. Prodigiosin (PG) was used as the model anti-tumor drug, targeting aggressive tumor cells. The morphology, properties and composition and grafting process were characterized by transmission electron microscope (TEM), Fourier transform infrared spectroscopy (FT-IR), vibration sample magnetometer (VSM), X-ray diffraction (XRD) analysis...
July 18, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28740380/inhibition-of-cell-proliferation-through-an-atp-responsive-co-delivery-system-of-doxorubicin-and-bcl-2-sirna
#19
Jianxu Zhang, Yudi Wang, Jiawen Chen, Xiao Liang, Haobo Han, Yan Yang, Quanshun Li, Yanbo Wang
Herein, DNA duplex was constructed through the hybridization of adenosine triphosphate (ATP)-responsive aptamer and its cDNA in which GC-rich motif could be used to load doxorubicin (DOX), and then, cationic polymer PEI25K was used as a carrier to simultaneously condense DOX-Duplex and Bcl-2 siRNA to prepare the ternary nanocomplex polyethylenimine (PEI)/DOX-Duplex/siRNA. The ATP concentration gradient between the cytosol and extracellular environment could achieve the stable loading of DOX in duplex and the rapid drug release in an ATP-responsive manner...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28738290/cell-targeting-peptides-as-smart-ligands-for-targeting-of-therapeutic-or-diagnostic-agents-a-systematic-review
#20
REVIEW
Ali Mousavizadeh, Ali Jabbari, Mohammad Akrami, Hassan Bardania
Cell targeting peptides (CTP) are small peptides which have high affinity and specificity to a cell or tissue targets. They are typically identified by using phage display and chemical synthetic peptide library methods. CTPs have attracted considerable attention as a new class of ligands to delivery specifically therapeutic and diagnostic agents, because of the fact they have several advantages including easy synthesis, smaller physical sizes, lower immunogenicity and cytotoxicity and their simple and better conjugation to nano-carriers and therapeutic or diagnostic agents compared to conventional antibodies...
July 13, 2017: Colloids and Surfaces. B, Biointerfaces
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