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https://www.readbyqxmd.com/read/29747596/hand-assisted-living-donor-nephrectomy-a-retrospective-comparison-of-two-techniques
#1
Jeannette D Widmer, Andrea Schlegel, Philipp Kron, Marc Schiesser, Jens G Brockmann, Markus K Muller
BACKGROUND: Living-donor nephrectomy (LDN) is challenging, as surgery is performed on healthy individuals. Minimally invasive techniques for LDN have become standard in most centers. Nevertheless, numerous techniques have been described with no consensus on which is the superior approach. Both hand-assisted retroperitoneoscopic (HARS) and hand-assisted laparoscopic (HALS) LDNs are performed at Zurich University Hospital. The aim of this study was to compare these two surgical techniques in terms of donor outcome and graft function...
May 10, 2018: BMC Urology
https://www.readbyqxmd.com/read/29736214/masquelet-s-induced-membrane-promotes-the-osteogenic-differentiation-of-bone-marrow-mesenchymal-stem-cells-by-activating-the-smad-and-mapk-pathways
#2
Qian Tang, Minji Tong, Gang Zheng, Liyan Shen, Ping Shang, Haixiao Liu
The Masquelet's induced membrane (IM) technique is widely used to treat large segmental bone defects due to its physical priority and biological function. However, the underlying molecular mechanism of the IM on bone formation remains unknown. In the present study, rat bone marrow-derived mesenchymal stem cells (BMSCs) were used as an in vitro model and bone morphogenetic protein 2 (BMP-2) was used as a positive control to evaluate the effects of the IM on the osteogenic differentiation of BMSCs. Although the IM group did not exhibit a significant increase in the expression of Runt-related transcription factor 2 (Runx2), Collagen I (Col I), osteocalcin (OCN) and alkaline phosphatase (ALP) relative to the BMP-2 administration, the IM was considerably effective compared with the untreated group...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/29700358/premyogenic-progenitors-derived-from-human-pluripotent-stem-cells-expand-in-floating-culture-and-differentiate-into-transplantable-myogenic-progenitors
#3
Fusako Sakai-Takemura, Asako Narita, Satoru Masuda, Toshifumi Wakamatsu, Nobuharu Watanabe, Takashi Nishiyama, Ken'ichiro Nogami, Matthias Blanc, Shin'ichi Takeda, Yuko Miyagoe-Suzuki
Human induced pluripotent stem cells (hiPSCs) are a potential source for cell therapy of Duchenne muscular dystrophy. To reliably obtain skeletal muscle progenitors from hiPSCs, we treated hiPS cells with a Wnt activator, CHIR-99021 and a BMP receptor inhibitor, LDN-193189, and then induced skeletal muscle cells using a previously reported sphere-based culture. This protocol greatly improved sphere formation efficiency and stably induced the differentiation of myogenic cells from hiPS cells generated from both healthy donors and a patient with congenital myasthenic syndrome...
April 26, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29692507/a-retrospective-analysis-of-complications-of-laparoscopic-left-donor-nephrectomy-using-the-kocak-s-modification-of-clavien-dindo-system
#4
Aneesh Srivastava, Ankur Bansal, Sanjoy K Sureka, Priyank Yadav, Devarshi Srivastava, Rahul Jena, Uday P Singh, Saurabh Vashishtha, M S Ansari, Rakesh Kapoor
Introduction: Kocak described a modification of Clavien-Dindo classification system (CDCS) for reporting procedure-related complications in laparoscopic donor nephrectomy (LDN). We used the Kocak modification in grading and reporting the severity of complications in patients who underwent LDN and in evaluating various parameters that predict them. Methods: In all, 1430 patients who underwent left LDN from 2000 to 2016 were included in this study. All data was retrospectively collected and analyzed for complications occurring in the postoperative period...
April 2018: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/29689493/are-lexical-tones-musical-native-language-s-influence-on-neural-response-to-pitch-in-different-domains
#5
Ao Chen, Varghese Peter, Frank Wijnen, Hugo Schnack, Denis Burnham
Language experience shapes musical and speech pitch processing. We investigated whether speaking a lexical tone language natively modulates neural processing of pitch in language and music as well as their correlation. We tested tone language (Mandarin Chinese), and non-tone language (Dutch) listeners in a passive oddball paradigm measuring mismatch negativity (MMN) for (i) Chinese lexical tones and (ii) three-note musical melodies with similar pitch contours. For lexical tones, Chinese listeners showed a later MMN peak than the non-tone language listeners, whereas for MMN amplitude there were no significant differences between groups...
April 21, 2018: Brain and Language
https://www.readbyqxmd.com/read/29677546/bacitracin-promotes-osteogenic-differentiation-of-human-bone-marrow-mesenchymal-stem-cells-by-stimulating-the-bone-morphogenetic-protein-2-smad-axis
#6
Hui Li, Bin'en Nie, Zhe Du, Shutao Zhang, Teng Long, Bing Yue
Bacitracin, a widely used metallopeptide antibiotic, has been reported to be locally used in treating wounds without systemic adverse reactions. Our preliminary study showed that bacitracin might enhance the osteogenic differentiation of human bone marrow mesenchymal stem cells (HBMSCs). The present study investigated whether bacitracin affects the osteogenic differentiation of HBMSCs and the molecular mechanisms involved. The proliferation of HBMSCs in the presence of bacitracin was examined using a cell counting kit-8 (CCK-8) assay...
April 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29668215/limited-distribution-networks-stifle-competition-in-the-generic-and-biosimilar-drug-industries
#7
Laura Karas, Kenneth M Shermock, Celia Proctor, Mariana Socal, Gerard F Anderson
A limited distribution network (LDN) restricts the distribution channel for a pharmaceutical drug to 1 or a very small number of distributors. This strategy may allow for more effective allocation of drugs in shortage and is purported to help ensure the safe distribution of high-risk drugs to small patient populations. However, in recent years, some drug companies, including Turing Pharmaceuticals, have used LDNs to prevent generic and biosimilar companies from accessing samples of drug products necessary to perform testing required by the FDA for generic and biosimilar drug applications...
April 1, 2018: American Journal of Managed Care
https://www.readbyqxmd.com/read/29615437/refinement-of-in-vitro-methods-for-identification-of-aldehyde-oxidase-substrates-reveals-novel-metabolites-of-kinase-inhibitors
#8
Ryan A Dick
An assay procedure was developed to identify AO substrates that leverages the capabilities of high resolution mass spectrometry to simultaneously monitor parent loss and formation of hydroxylated metabolite over time in incubations with liver cytosol. By incorporating metabolite monitoring, false positives resulting from metabolism by other cytosolic enzymes or processes were decreased. A diverse set of 34 kinase inhibitors containing AO-substrate motifs was screened and 35% of the compounds were identified as human AO substrates...
April 3, 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/29607497/low-dose-naltrexone-for-induction-of-remission-in-crohn-s-disease
#9
REVIEW
Claire E Parker, Tran M Nguyen, Dan Segal, John K MacDonald, Nilesh Chande
BACKGROUND: Crohn's disease is a transmural, relapsing inflammatory condition afflicting the digestive tract. Opioid signalling, long known to affect secretion and motility in the gut, has been implicated in the inflammatory cascade of Crohn's disease. Low dose naltrexone, an opioid antagonist, has garnered interest as a potential therapy. OBJECTIVES: The primary objective was to evaluate the efficacy and safety of low dose naltrexone for induction of remission in Crohn's disease...
April 1, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29523156/low-dose-naltrexone-for-induction-of-remission-in-inflammatory-bowel-disease-patients
#10
Mitchell R K L Lie, Janine van der Giessen, Gwenny M Fuhler, Alison de Lima, Maikel P Peppelenbosch, Cokkie van der Ent, C Janneke van der Woude
BACKGROUND: Around 30% of patients with inflammatory bowel disease (IBD) are refractory to current IBD drugs or relapse over time. Novel treatments are called for, and low dose Naltrexone (LDN) may provide a safe, easily accessible alternative treatment option for these patients. We investigated the potential of LDN to induce clinical response in therapy refractory IBD patients, and investigated its direct effects on epithelial barrier function. METHODS: Patients not in remission and not responding to conventional therapy were offered to initiate LDN as a concomitant treatment...
March 9, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29521532/cortical-responses-to-chinese-phonemes-in-preschoolers-predict-their-literacy-skills-at-school-age
#11
Tian Hong, Lan Shuai, Stephen J Frost, Nicole Landi, Kenneth R Pugh, Hua Shu
We investigated whether preschoolers with poor phonological awareness (PA) skills had impaired cortical basis for detecting speech feature, and whether speech perception influences future literacy outcomes in preschoolers. We recorded ERP responses to speech in 52 Chinese preschoolers. The results showed that the poor PA group processed speech changes differentially compared to control group in mismatch negativity (MMN) and late discriminative negativity (LDN). Furthermore, speech perception in kindergarten could predict literacy outcomes after literacy acquisition...
2018: Developmental Neuropsychology
https://www.readbyqxmd.com/read/29521016/dullard-deficiency-causes-hemorrhage-in-the-adult-ovarian-follicles
#12
Tadayoshi Hayata, Masahiko Chiga, Yoichi Ezura, Makoto Asashima, Hidetaka Katabuchi, Ryuichi Nishinakamura, Masaki Noda
In mammals, the ovarian follicles are regulated at least in part by bone morphogenetic protein (BMP) family members. Dullard (also known as Ctdnep1) gene encodes a phosphatase that suppresses BMP signaling by inactivating or degrading BMP receptors. Here we report that the Col1a1-Cre-induced Dullard mutant mice displayed hemorrhagic ovarian cysts, with red blood cells accumulated in the follicles, resulting in infertility. Cells expressing Cre driven by Col1a1 2.3-kb promoter and their descendants were found in granulosa cells in the ovary and in Sertoli cells in the testis...
May 2018: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://www.readbyqxmd.com/read/29462615/ubiquitin-c-terminal-hydrolase-l1-regulates-autophagy-by-inhibiting-autophagosome-formation-through-its-deubiquitinating-enzyme-activity
#13
Cong Yan, Huanhuan Huo, Cuiwei Yang, Tao Zhang, Yuanyuan Chu, Yanfen Liu
Ubiquitination modification has been shown to play a key role in autophagy. Increasing studies reported the involvement of de-ubiquitinating enzymes (DUBs) in autophagy pathway. To systematically search how DUBs manipulate autophagy, we utilized a double fluorescence tagged LC3 stable HeLa cell line, and did a genome wide screen of 55 human DUBs which is about 60% coverage of the DUB family. We found a bunch of DUBs have impact on autophagy by either changing the LC3 puncta formation or the autophagy flux. One of them, Ubiquitin C-Terminal Hydrolase L1 (UCHL1) correlated to Parkinson's disease, strongly affects autophagy by inhibiting autophagosome formation...
March 4, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29461442/3d-endoscopic-donor-nephrectomy-versus-robot-assisted-donor-nephrectomy-a-detailed-comparison-of-2-prospective-cohorts
#14
Evalyn E A P Mulder, Shiromani Janki, Türkan Terkivatan, Karel W J Klop, Jan N M IJzermans, T C Khe Tran
BACKGROUND: There are 2 endoscopic surgical techniques that implement 3D vision to overcome visual misperception: 3D endoscopy and the da Vinci surgical system. 3D endoscopy has several advantages, such as the presence of tactile feedback and easy implementation, at lower costs. We aimed to assess whether 3D endoscopy could be an alternative to the robot during living donor nephrectomy (LDN). METHODS: Between April 2015 and April 2016 we prospectively collected data on 40 patients undergoing 3D endoscopic LDNs in 1 center, performed by a da Vinci certified surgeon...
February 14, 2018: Transplantation
https://www.readbyqxmd.com/read/29457601/influences-of-combined-traffic-noise-on-the-ability-of-learning-and-memory-in-mice
#15
Guo-Qing Di, Zhao-Qi Qin
Objective: The present study aimed to evaluate the influences of combined traffic noise (CTN) on the ability of learning and memory in mice. Materials and Methods: The Institute of Cancer Research (ICR) mice were exposed to CTN from highways and high-speed railways for 42 days, whose day-night equivalent continuous A-weighted sound pressure level (Ldn ) was 70 dB(A). On the basis of behavioral reactions in Morris water maze (MWM) and the concentrations of amino acid neurotransmitters in the hippocampus, the impacts of CTN on learning and memory in mice were examined...
January 2018: Noise & Health
https://www.readbyqxmd.com/read/29392867/impact-of-center-volume-and-the-adoption-of-laparoscopic-donor-nephrectomy-on-outcomes-in-pediatric-kidney-transplantation
#16
Jennifer M Burg, David L Scott, Kayvan Roayaie, Erin Maynard, John M Barry, C Kristian Enestvedt
Reports for pediatric kidney transplant recipients suggested better outcomes for ODN compared to LDN. Contemporary outcomes stratified by donor type and center volume have not been evaluated in a national dataset. UNOS data (2000-2014) were analyzed for pediatric living donor kidney transplant recipients. The primary outcome was GF; secondary outcomes were DGF, rejection, and patient survival. Live donor nephrectomies for pediatric recipients decreased 30% and transitioned from ODN to LDN. GF rates did not differ for ODN vs LDN (P = ...
May 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29390875/defined-culture-conditions-accelerate-small-molecule-assisted-neural-induction-for-the-production-of-neural-progenitors-from-human-induced-pluripotent-stem-cells
#17
Patrick Walsh, Vincent Truong, Caitlin Hill, Nicolas D Stoflet, Jessica Baden, Walter C Low, Susan A Keirstead, James R Dutton, Ann M Parr
The use of defined conditions for derivation, maintenance, and differentiation of human-induced pluripotent stem cells (hiPSCs) provides a superior experimental platform to discover culture responses to differentiation cues and elucidate the basic requirements for cell differentiation and fate restriction. Adoption of defined systems for reprogramming, undifferentiated growth, and differentiation of hiPSCs was found to significantly influence early stage differentiation signaling requirements and temporal kinetics for the production of primitive neuroectoderm...
December 2017: Cell Transplantation
https://www.readbyqxmd.com/read/29385430/the-effect-of-low-dose-naltrexone-on-medication-in-inflammatory-bowel-disease-a-quasi-experimental-before-and-after-prescription-database-study
#18
Guttorm Raknes, Pia Simonsen, Lars Småbrekke
Background and Aims: Low dose naltrexone (LDN) is a controversial off-label treatment used by many Crohn's disease (CD) and ulcerative colitis (UC) patients. A small number of preliminary studies indicate that LDN might be beneficial in CD, but evidence is too scarce to demonstrate efficacy. We wanted to examine whether initiation of LDN therapy by patients with inflammatory bowel disease (IBD) was followed by changes in dispensing of relevant medication. Methods: We performed a quasi-experimental before and after study following a sudden increase of LDN use in the Norwegian population in 2013...
January 27, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29382442/hilar-control-during-laparoscopic-donor-nephrectomy-practice-patterns-in-canada
#19
Thomas B Mcgregor, Premal Patel, Gabriel Chan, Alp Sener
INTRODUCTION: In recent years, the method of vascular control during laparoscopic donor nephrectomy (LDN) has come under scrutiny due to catastrophic consequences of a device failure. This study sought to examine the surgical preferences of Canadian donor surgeons with regards to vascular control and their perception on the safety of these modalities. We also surveyed the experience with device malfunction and their subsequent management during LDN. METHODS: An online survey was sent out to donor surgeons registered with the Canadian Society of Transplantation...
October 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29330531/low-density-neutrophils-ldn-in-postoperative-abdominal-cavity-assist-the-peritoneal-recurrence-through-the-production-of-neutrophil-extracellular-traps-nets
#20
Rihito Kanamaru, Hideyuki Ohzawa, Hideyo Miyato, Shiro Matsumoto, Hidenori Haruta, Kentaro Kurashina, Shin Saito, Yoshinori Hosoya, Hironori Yamaguchi, Hiroharu Yamashita, Yasuyuki Seto, Alan Kawarai Lefor, Naohiro Sata, Joji Kitayama
Many types of immune cells appear in peritoneal cavity after abdominal surgery. In patients who underwent laparotomy due to gastric cancer, peritoneal lavages were obtained before and after surgical procedure. Cells were recovered from intermediate layer after Ficoll-Hypaque centrifugation and analyzed for phenotypes and functions, especially focused on low density neutrophils (LDN). The number of CD66b (+) LDN with mature phenotype was markedly elevated in postoperative as compared with preoperative lavages...
January 12, 2018: Scientific Reports
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