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https://www.readbyqxmd.com/read/27912947/exploratory-outcome-assessment-of-qigong-tai-chi-easy-on-breast-cancer-survivors
#1
Linda K Larkey, Denise J Roe, Lisa Smith, Denise Millstine
OBJECTIVE: Breast cancer survivors (BCSs) experience symptoms affecting overall quality of life (QOL), often for a prolonged period post-treatment. Meditative Movement (MM), including Qigong and Tai Chi Easy (QG/TCE), has demonstrated benefit for improving QOL issues such as fatigue and sleep, but there is limited evidence of its impact on cognitive function, overall physical activity, and body weight for BCSs. DESIGN: This double-blind, randomized controlled pilot study with 87 female BCSs explored effects of QG/TCE on mental and physical QOL (Medical Outcomes Survey, Short Form), cognitive function (Functional Assessment of Cancer Therapy-Cognitive Function and two cognitive performance tests from the WAIS III), overall levels of physical activity (PA)(Brief Physical Activity Questionnaire) and body mass index (BMI)...
December 2016: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/27912863/circadian-rhythm-and-sleep-during-prolonged-antarctic-residence-at-chinese-zhongshan-station
#2
Nan Chen, Quan Wu, Yanlei Xiong, Guang Chen, Dandan Song, Chengli Xu
OBJECTIVE: Residence at Zhongshan Station (69°22'24″S, 76°22'40″E) for over 1 year exposes winter-over members to marked changes of light-dark cycle, ranging from the constant daylight of polar days to the constant darkness of polar nights, in addition to geographic and social isolation. This extreme photoperiodic environment may increase the risk of sleep disturbances and circadian desynchrony. The aim of this study was to investigate the circadian rhythm and sleep phase of Chinese winter-over expeditioners at Zhongshan Station...
December 2016: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/27909991/the-role-of-orexins-hypocretins-in-alcohol-use-and-abuse
#3
Leigh C Walker, Andrew J Lawrence
Addiction is a chronic relapsing disorder characterized by compulsive drug seeking and drug taking despite negative consequences. Alcohol abuse and addiction have major social and economic consequences and cause significant morbidity and mortality worldwide. Currently available therapeutics are inadequate, outlining the need for alternative treatments. Detailed knowledge of the neurocircuitry and brain chemistry responsible for aberrant behavior patterns should enable the development of novel pharmacotherapies to treat addiction...
December 2, 2016: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/27904735/urinary-metabolomics-of-young-italian-autistic-children-supports-abnormal-tryptophan-and-purine-metabolism
#4
Federica Gevi, Lello Zolla, Stefano Gabriele, Antonio M Persico
BACKGROUND: Autism spectrum disorder (ASD) is still diagnosed through behavioral observation, due to a lack of laboratory biomarkers, which could greatly aid clinicians in providing earlier and more reliable diagnoses. Metabolomics on human biofluids provides a sensitive tool to identify metabolite profiles potentially usable as biomarkers for ASD. Initial metabolomic studies, analyzing urines and plasma of ASD and control individuals, suggested that autistic patients may share some metabolic abnormalities, despite several inconsistencies stemming from differences in technology, ethnicity, age range, and definition of "control" status...
2016: Molecular Autism
https://www.readbyqxmd.com/read/27904509/a-new-diagnostic-tool-for-masked-hypertension-impaired-sleep-quality
#5
Fatma Erdem, Ugur Cakır, Osman Yıldırım, Aytekin Alcelik, Ibrahim Donmez, Taha Can Tuman, Sabri Onur Caglar, Alim Erdem, Mehmet Yazıcı
INTRODUCTION: The aim of this study was to evaluate the relationship between masked hypertension and impaired sleep quality. Additionally, we evaluated the diagnostic role and prevalence of poor sleep quality among patients with newly diagnosed masked hypertension. MATERIAL AND METHODS: A total of 112 individuals, 72 patients with newly diagnosed masked hypertension and 40 normotensive healthy volunteers, were included in this study. All patients underwent evaluation comprising 12-lead electrocardiography, transthoracic echocardiography, 24-hour Holter ECG, and basic laboratory tests...
December 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27904104/the-effects-of-unilateral-nephrectomy-on-blood-pressure-and-its-circadian-rhythm
#6
Naro Ohashi, Shinsuke Isobe, Sayaka Ishigaki, Takahisa Suzuki, Daisuke Motoyama, Takayuki Sugiyama, Masao Nagata, Akihiko Kato, Seiichiro Ozono, Hideo Yasuda
Objective Hypertension and diurnal blood pressure (BP) variation are widely accepted as risk factors for renal damage. However, the effects of unilateral nephrectomy on BP and its circadian rhythm have not yet been clarified in patients with a compromised renal function, including dialysis patients. Methods We investigated 22 unilateral nephrectomized patients (16 men and 6 women, age: 64.5±14.3 years). The function of the circulating renin-angiotensin system (RAS) (plasma renin activity and plasma angiotensin II) and 24-h ambulatory BP monitoring (ABPM) were evaluated before and after nephrectomy...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27900583/does-elite-sport-degrade-sleep-quality-a-systematic-review
#7
REVIEW
Luke Gupta, Kevin Morgan, Sarah Gilchrist
BACKGROUND: Information on sleep quality and insomnia symptomatology among elite athletes remains poorly systematised in the sports science and medicine literature. The extent to which performance in elite sport represents a risk for chronic insomnia is unknown. OBJECTIVES: The purpose of this systematic review was to profile the objective and experienced characteristics of sleep among elite athletes, and to consider relationships between elite sport and insomnia symptomatology...
November 29, 2016: Sports Medicine
https://www.readbyqxmd.com/read/27899727/using-smartphones-to-collect-behavioral-data-in-psychological-science-opportunities-practical-considerations-and-challenges
#8
Gabriella M Harari, Nicholas D Lane, Rui Wang, Benjamin S Crosier, Andrew T Campbell, Samuel D Gosling
Smartphones now offer the promise of collecting behavioral data unobtrusively, in situ, as it unfolds in the course of daily life. Data can be collected from the onboard sensors and other phone logs embedded in today's off-the-shelf smartphone devices. These data permit fine-grained, continuous collection of people's social interactions (e.g., speaking rates in conversation, size of social groups, calls, and text messages), daily activities (e.g., physical activity and sleep), and mobility patterns (e.g., frequency and duration of time spent at various locations)...
November 2016: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
https://www.readbyqxmd.com/read/27899291/dynamic-changes-in-sleep-pattern-during-post-partum-in-normal-pregnancy-in-rat-model
#9
Neelima Sivadas, Arathi Radhakrishnan, B S Aswathy, Velayudhan Mohan Kumar, Kamalesh K Gulia
To develop an animal model for studies on peri-partum sleep disorders, sleep patterns in female Wistar rats during pregnancy, post-partum and after weaning, were assessed and associated adaptive changes in their anxiety were examined. Adult nulliparous female rats, maintained in standard laboratory conditions with ad libitum food and water, were surgically implanted with electroencephalogram and electromyogram electrodes under anaesthesia for objective assessment of sleep-wakefulness (S-W). After post-surgical recovery, three control recordings of S-W were taken for 24h before the animals were kept for mating...
November 26, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27898092/transposon-mediated-generation-of-cellular-and-mouse-models-of-splicing-mutations-to-assess-the-efficacy-of-snrna-based-therapeutics
#10
Elena Barbon, Mattia Ferrarese, Laetitia van Wittenberghe, Peggy Sanatine, Giuseppe Ronzitti, Fanny Collaud, Pasqualina Colella, Mirko Pinotti, Federico Mingozzi
Disease-causing splicing mutations can be rescued by variants of the U1 small nuclear RNA (U1snRNAs). However, the evaluation of the efficacy and safety of modified U1snRNAs as therapeutic tools is limited by the availability of cellular and animal models specific for a given mutation. Hence, we exploited the hyperactive Sleeping Beauty transposon system (SB100X) to integrate human factor IX (hFIX) minigenes into genomic DNA in vitro and in vivo. We generated stable HEK293 cell lines and C57BL/6 mice harboring splicing-competent hFIX minigenes either wild type (SChFIX-wt) or mutated (SChFIXex5-2C)...
November 29, 2016: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/27893500/the-effect-of-reported-sleep-perceived-fatigue-and-sleepiness-on-cognitive-performance-in-a-sample-of-emergency-nurses
#11
Lisa A Wolf, Cydne Perhats, Altair Delao, Zoran Martinovich
OBJECTIVE: The aim of this study is to explore the relationship between reported sleep, perceived fatigue and sleepiness, and cognitive performance. BACKGROUND: Although evidence suggests that fatigue and sleepiness affect the provision of care in inpatient units, there is a lack of research on the sleep patterns of emergency nurses and the effects of disturbed sleep and fatigue on their cognitive abilities and susceptibility to medical errors. METHODS: A quantitative correlational design was used in this study; in each of 7 different statistical models, zero-order relationships between predictors and the dependent variable were examined with appropriate inferential tests...
November 23, 2016: Journal of Nursing Administration
https://www.readbyqxmd.com/read/27891657/sleep-differences-in-one-year-old-children-were-related-to-obesity-risks-based-on-their-parents-weight-according-to-baseline-longitudinal-study-data
#12
Mirjam Ekstedt, Mojgan Haji Seyed Ebrahim Darkeh, Lijuan Xiu, Michaela Forssén, Elin Johansson, Anna Ek, Viktoria Svensson, Kerstin Ekbom, Claude Marcus
AIM: Parental obesity is the predominant risk factor for child obesity. We compared sleep in one-year-old children with different obesity risks, based on parental weight, and explored associations with weight, parental sleep and family factors. METHODS: Baseline data from 167 families participating in a longitudinal obesity prevention programme was used. Sleep patterns were compared between groups with high and low obesity risks, based on parental weight, and associations between child sleep and weight status, family obesity risk and parental sleep were explored...
November 7, 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27891080/enhanced-burst-suppression-and-disruption-of-local-field-potential-synchrony-in-a-mouse-model-of-focal-cortical-dysplasia-exhibiting-spike-wave-seizures
#13
Anthony J Williams, Chen Zhou, Qian-Quan Sun
Focal cortical dysplasias (FCDs) are a common cause of brain seizures and are often associated with intractable epilepsy. Here we evaluated aberrant brain neurophysiology in an in vivo mouse model of FCD induced by neonatal freeze lesions (FLs) to the right cortical hemisphere (near S1). Linear multi-electrode arrays were used to record extracellular potentials from cortical and subcortical brain regions near the FL in anesthetized mice (5-13 months old) followed by 24 h cortical electroencephalogram (EEG) recordings...
2016: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/27889818/somatosensory-reflex-seizures-in-a-child-with-epilepsy-related-to-novel-scn1a-mutation
#14
Pinar Arican, Nihal Olgac Dundar, Dilek Cavusoglu, Taha Resid Ozdemır, Pinar Gencpinar
INTRODUCTION: Mutations in SCN1A have been reported in patients with different types of epilepsy, including generalized epilepsy with febrile seizures plus, severe myoclonic epilepsy in infancy, malignant migrating partial seizures in infancy, and other infantile epileptic encephalopathies. CASE REPORT: We report a case of a 10-month-old girl presented with reflex epileptic seizures provoked by somatosensory stimuli with a novel de novo mutation of SCN1A gene. She was observed to have seizures with eye deviation, unresponsiveness provoked by somatosensory stimuli of the face...
November 26, 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27888835/the-association-between-benzodiazepine-use-and-sleep-quality-in-residential-aged-care-facilities-a-cross-sectional-study
#15
Lynna Chen, J Simon Bell, Renuka Visvanathan, Sarah N Hilmer, Tina Emery, Leonie Robson, Jessica M Hughes, Edwin C K Tan
BACKGROUND: Benzodiazepines are commonly prescribed in residential aged care facilities (RACFs) for their sedative and anxiolytic effects. The objective of this study was to investigate the association between benzodiazepine use and sleep quality in residents of RACFs. METHODS: A cross-sectional study involving 383 participants was conducted in six Australian RACFs. Night-time sleep quality, day-time drowsiness and day-time napping behavior were assessed using a validated questionnaire...
November 26, 2016: BMC Geriatrics
https://www.readbyqxmd.com/read/27888574/normal-heart-in-parkinson-s-disease-is-this-a-distinct-clinical-phenotype
#16
J-S Kim, H-E Park, I-S Park, Y-S Oh, D-W Ryu, I-U Song, Y-A Jung, I R Yoo, H-S Choi, P H Lee, K-S Lee
BACKGROUND AND PURPOSE: Reduction of metaiodobenzylguanidine (MIBG) uptake has been observed in almost all patients with Parkinson's disease (PD), associated with hyposmia, orthostatic hypotension and rapid eye movement sleep behavioral disorder (RBD). In contrast, a subgroup of patients with PD with normal MIBG uptake have been reported to have milder disease and preserved cognition compared with those with lower MIBG. The aim of this study was to investigate whether non-motor manifestations of PD differ between patients with normal and abnormal myocardial MIBG uptake...
November 26, 2016: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/27887910/assessment-of-serum-level-of-corticotropin-releasing-factor-in-primary-nocturnal-enuresis
#17
Ayat A Motawie, Amany M Abd Al-Aziz, Hanan M Hamed, Amany A A Fatouh, Mona A M Awad, Amany Abd El-Ghany
INTRODUCTION: Primary nocturnal enuresis is one of the sleep related phenomena characterized by disruption in the relationship between arousal and urination. Corticotropin-releasing factor (CRF) is a neurohormone released from the paraventricular nucleus of the hypothalamus into the median eminence to elicit release of adrenocorticotrophin from the anterior pituitary. It may act to modulate autonomic function and behavior in concert with the endocrine effects. Conflicting animal studies about the role of CRF in micturition, either facilitating or inhibiting, have been raised...
October 24, 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27887654/proportion-of-children-meeting-recommendations-for-24-hour-movement-guidelines-and-associations-with-adiposity-in-a-12-country-study
#18
Blanca Roman-Viñas, Jean-Philippe Chaput, Peter T Katzmarzyk, Mikael Fogelholm, Estelle V Lambert, Carol Maher, Jose Maia, Timothy Olds, Vincent Onywera, Olga L Sarmiento, Martyn Standage, Catrine Tudor-Locke, Mark S Tremblay
BACKGROUND: The Canadian 24-h movement guidelines were developed with the hope of improving health and future health outcomes in children and youth. The purpose of this study was to evaluate adherence to the 3 recommendations most strongly associated with health outcomes in new 24-h movement guidelines and their relationship with adiposity (obesity and body mass index z-score) across countries participating in the International Study of Childhood Obesity, Lifestyle and the Environment (ISCOLE)...
November 25, 2016: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/27884756/repeated-unpredictable-threats-without-harm-impair-spatial-working-memory-in-the-barnes-maze
#19
Diane J Kim, Nathan St Louis, Ralph A Molaro, Glenn T Hudson, Robert C Chorley, Brenda J Anderson
Psychological stressors elicit the anticipation of homeostatic challenge, whereas physical stressors are direct threats to homeostasis. Many rodent models of stress include both types of stressors, yet deficits, like those reported for working memory, are often attributed to psychological stress. To empirically test whether intermittent psychological stressors, such as repeated threats, are solely sufficient to impair spatial working memory, we developed a novel rodent model of stress that is restricted to the anticipation of threat, and free of direct physical challenge...
November 21, 2016: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/27884172/spatial-distribution-and-trypanosome-infection-of-tsetse-flies-in-the-sleeping-sickness-focus-of-zimbabwe-in-hurungwe-district
#20
William Shereni, Neil E Anderson, Learnmore Nyakupinda, Giuliano Cecchi
BACKGROUND: In Zimbabwe, cases of human African trypanosomiasis (HAT) are caused by the unicellular protozoan Trypanosoma brucei, sub-species T. b. rhodesiense. They are reported from the tsetse-infested area in the northern part of the country, broadly corresponding to the valley of the Zambezi River. Tsetse-transmitted trypanosomes, in particular T. congolense and T. vivax, also cause morbidity and mortality in livestock, thus generating poverty and food insecurity. Two species of tsetse fly, Glossina morsistans morsitans and G...
November 25, 2016: Parasites & Vectors
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