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Irritable Bowel Syndrom

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https://www.readbyqxmd.com/read/28811802/clinical-features-and-risk-factors-for-irritable-bowel-syndrome-in-migraine-patients
#1
Chunlin Li, Shengyuan Yu, Huiying Li, Jin Zhou, Jieqiong Liu, Wenjing Tang, Lei Zhang
OBJECTIVE: Clinical and basic research increasingly suggests a correlation between migraine and irritable bowel syndrome (IBS). In this study, we aimed to explore the clinical features and risk factors for IBS in migraine patients. METHODS: This was a retrospective, cross-sectional study. A total of 1,112 consecutive patients from the internal medicine and emergency departments of three hospitals from June 2014 through 2016. A comprehensive interviewer-administered questionnaire was designed based on the International Classification of Headache Disorders, 3rd edition (beta version)...
May 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28809383/increasing-symptoms-in-irritable-bowel-symptoms-with-ingestion-of-galacto-oligosaccharides-are-mitigated-by-%C3%AE-galactosidase-treatment
#2
C J Tuck, K M Taylor, P R Gibson, J S Barrett, J G Muir
OBJECTIVES: Galacto-oligosaccharides (GOS) are dietary FODMAPs (fermentable carbohydrates) associated with triggering gastrointestinal symptoms in patients with irritable bowel syndrome (IBS). This randomized, double-blind, placebo-controlled, cross-over trial aimed to assess whether oral α-galactosidase co-ingestion with foods high in GOS and low in other FODMAPs would reduce symptoms. METHODS: Patients meeting the Rome III criteria for IBS who were hydrogen-producers on breath testing were recruited...
August 15, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28808081/%C3%A2-eluxadoline-for-ibs-d
#3
(no author information available yet)
Irritable bowel syndrome (IBS) is a chronic relapsing gastrointestinal problem characterised by intestinal pain and associated alterations of defecation and/or bowel habit (constipation: IBS-C or diarrhoea: IBS-D).(1,2) Opioid receptors in the gut have a role in gastrointestinal motility, secretion and sensation.(3) Τ Eluxadoline (Truberzi-Allergan) is a locally acting, mixed opioid receptor agonist/antagonist licensed for the treatment of IBS-D in adults.(4) Here, we consider the evidence for eluxadoline and how it fts with current management strategies for IBS-D...
August 2017: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/28806407/low-fermentable-oligosaccharides-disaccharides-monosaccharides-and-polyols-fodmap-diet-improves-symptoms-in-adults-suffering-from-irritable-bowel-syndrome-ibs-compared-to-standard-ibs-diet-a-meta-analysis-of-clinical-studies
#4
Péter Varjú, Nelli Farkas, Péter Hegyi, András Garami, Imre Szabó, Anita Illés, Margit Solymár, Áron Vincze, Márta Balaskó, Gabriella Pár, Judit Bajor, Ákos Szűcs, Orsolya Huszár, Dániel Pécsi, József Czimmer
BACKGROUND: Irritable bowel syndrome (IBS) and functional digestive tract disorders, e.g. functional bloating, carbohydrate maldigestion and intolerances, are very common disorders frequently causing significant symptoms that challenge health care systems. A low Fermentable Oligosaccharides, Disaccharides, Monosaccharides and Polyols (FODMAP) diet is one of the possible therapeutic approaches for decreasing abdominal symptoms and improving quality of life. OBJECTIVES: We aimed to meta-analyze data on the therapeutic effect of a low-FODMAP diet on symptoms of IBS and quality of life and compare its effectiveness to a regular, standard IBS diet with high FODMAP content, using a common scoring system, the IBS Symptom Severity Score (IBS-SSS)...
2017: PloS One
https://www.readbyqxmd.com/read/28806140/adherent-invasive-e-coli-enhances-colonic-hypersensitivity-and-p2x-receptors-expression-during-post-infectious-period
#5
Amandine Lashermes, Ludivine Boudieu, Julie Barbier, Benoit Sion, Agathe Gelot, Nicolas Barnich, Denis Ardid, Frédéric Antonio Carvalho
Irritable Bowel Syndrome (IBS) and Inflammatory Bowel Disease (IBD) are related gastrointestinal disorders characterized by abdominal pain associated with colonic hypersensitivity (CHS). Studies in humans have reported an abnormal colonization of Adherent-Invasive E. coli (AIEC) in the ileum of Crohn's disease (CD) patients associated with overexpression of the bacterial colonizing receptor CEACAM6. The aim of the present study was to investigate whether AIEC reference strain LF82 could induce intestinal impairment during infectious and/or post-infectious periods and subsequently the development of CHS...
August 14, 2017: Gut Microbes
https://www.readbyqxmd.com/read/28804974/rome-iii-vs-rome-iv-criteria-for-irritable-bowel-syndrome-a-comparison-of-clinical-characteristics-in-a-large-cohort-study
#6
L Vork, Z Z R M Weerts, Z Mujagic, J W Kruimel, M A M Hesselink, J W M Muris, D Keszthelyi, D M A E Jonkers, A A M Masclee
BACKGROUND: The Rome criteria for irritable bowel syndrome (IBS) have been revised and are expected to apply only to the subset of Rome III IBS subjects with abdominal pain as predominant symptom, occurring at least once a week. The aim of this study was to determine the percentage of Rome III IBS subjects that fulfills Rome IV criteria and to evaluate differences between Rome IV-positive and Rome IV-negative subjects. METHODS: Four hundred and four Rome III IBS subjects completed a 14-day end-of-day symptom diary, the Gastrointestinal Symptom Rating Scale (GSRS), Hospital Anxiety and Depression Scale, and RAND 36-item Short-Form Health Survey (SF-36)...
August 14, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28804508/a-psychology-of-the-human-brain-gut-microbiome-axis
#7
Andrew P Allen, Timothy G Dinan, Gerard Clarke, John F Cryan
In recent years, we have seen increasing research within neuroscience and biopsychology on the interactions between the brain, the gastrointestinal tract, the bacteria within the gastrointestinal tract, and the bidirectional relationship between these systems: the brain-gut-microbiome axis. Although research has demonstrated that the gut microbiota can impact upon cognition and a variety of stress-related behaviours, including those relevant to anxiety and depression, we still do not know how this occurs. A deeper understanding of how psychological development as well as social and cultural factors impact upon the brain-gut-microbiome axis will contextualise the role of the axis in humans and inform psychological interventions that improve health within the brain-gut-microbiome axis...
April 2017: Social and Personality Psychology Compass
https://www.readbyqxmd.com/read/28803902/association-between-irritable-bowel-syndrome-and-overactive-bladder-a-research-survey
#8
Kyu Shik Kim, Hyung-Jee Kim, Seong Ho Lee, Sung Tae Cho, Hong Sang Moon
OBJECTIVE: To investigated the relationship between irritable bowel syndrome (IBS) and overactive bladder (OAB) in men and women using questionnaires. MATERIAL AND METHODS: This research survey was based on multi-center data (men and women older than 20 years). The Korean version of the Rome III criteria was used for the diagnosis of IBS, overactive bladder symptom score (OABSS) was used for screening OAB, Self-Rating Depression Scale (SDS) was used for depressive symptoms, and International Prostate Symptom Score & Quality of Life (IPSS & QoL) were used to determine the degrees of lower urinary tract symptoms...
August 10, 2017: Urology
https://www.readbyqxmd.com/read/28802472/complementary-and-integrative-gastroenterology
#9
REVIEW
Joshua Korzenik, Anna K Koch, Jost Langhorst
Complementary and integrative medicine is developing within gastroenterology, expanding options particularly for inflammatory bowel disease, irritable bowel syndrome, and reflux esophagitis. This article encompasses new developments in complementary integrative medicine with an emphasis on herbal therapies. Studies of potential therapies have been advancing with increasing sophistication. The best studied with the most promising results in ulcerative colitis is the use of curcumin both for the induction and maintenance of remission...
September 2017: Medical Clinics of North America
https://www.readbyqxmd.com/read/28799291/inaccuracy-of-patient-reported-descriptions-of-and-satisfaction-with-bowel-actions-in-irritable-bowel-syndrome
#10
E P Halmos, J R Biesiekierski, E D Newnham, R E Burgell, J G Muir, P R Gibson
BACKGROUND: Perception of diarrhea and constipation differs greatly. This study aimed to correlate subjective and objective assessment of fecal characteristics in irritable bowel syndrome (IBS) patients. METHODS: Data from two interventional dietary trials with varying FODMAP (Fermentable Oligosaccharides, Disaccharides, Monosaccharides And Polyols) or gluten content were interrogated. Subjects rated their dissatisfaction with stool consistency daily using a visual analog scale during the interventions...
August 10, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28798827/childhood-bladder-and-bowel-dysfunction-predicts-irritable-bowel-syndrome-phenotype-in-adult-interstitial-cystitis-bladder-pain-syndrome-patients
#11
R Christopher Doiron, Barry A Kogan, Victoria Tolls, Karen Irvine-Bird, J Curtis Nickel
INTRODUCTION: Many clinicians have suggested that a history of bladder and bowel dysfunction (BBD) in childhood predisposes to the development of interstitial cystitis/bladder pain syndrome (IC/BPS) or irritable bowel syndrome (IBS) in adulthood. We hypothesized that BBD symptoms in childhood would predict the IBS-associated phenotype in adult IC/BPS patients. METHODS: Consecutive female patients (n=190) with a diagnosis of IC/BPS were administered a modified form of a clinical BBD questionnaire (BBDQ) to capture childhood BBD-like symptoms, as well as Interstitial Cystitis Symptoms Index (ICSI), Interstitial Cystitis Problem Index (ICPI), Pelvic Pain and Urgency/Frequency (PUF) questionnaires and UPOINT categorization...
August 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28798012/internet-delivered-cognitive-behavioral-therapy-for-children-with-pain-related-functional-gastrointestinal-disorders-feasibility-study
#12
Maria Lalouni, Brjánn Ljótsson, Marianne Bonnert, Erik Hedman-Lagerlöf, Jens Högström, Eva Serlachius, Ola Olén
BACKGROUND: Pain-related functional gastrointestinal disorders (P-FGIDs; eg, irritable bowel syndrome) are highly prevalent in children and associated with low quality of life, anxiety, and school absence. Treatment options are scarce, and there is a need for effective and accessible treatments. Internet-delivered cognitive behavior therapy (Internet-CBT) based on exposure exercises is effective for adult and adolescent irritable bowel syndrome, but it has not been evaluated for younger children...
August 10, 2017: JMIR Mental Health
https://www.readbyqxmd.com/read/28790875/diarrhea-predominant-irritable-bowel-syndrome-creation-of-an-electronic-version-of-a-patient-reported-outcome-instrument-by-conversion-from-a-pen-and-paper-version-and-evaluation-of-their-equivalence
#13
Leticia Delgado-Herrera, Benjamin Banderas, Oluwafunke Ojo, Ritesh Kothari, Bernhardt Zeiher
BACKGROUND: Subjects with diarrhea-predominant irritable bowel syndrome (IBS-D) experience abdominal cramping, bloating, pressure, and pain. Due to an absence of clinical biomarkers for IBS-D severity, evaluation of clinical therapy benefits depends on valid and reliable symptom assessments. A patient-reported outcome (PRO) instrument has been developed, comprising of two questionnaires - the IBS-D Daily Symptom Diary and IBS-D Symptom Event Log - suitable for clinical trials and real-world settings...
2017: Patient related Outcome Measures
https://www.readbyqxmd.com/read/28790872/cognitive-behavioral-therapy-for-patients-with-irritable-bowel-syndrome-current-insights
#14
REVIEW
Sarah W Kinsinger
Irritable bowel syndrome (IBS) is a chronic gastrointestinal (GI) condition associated with significant health care utilization and quality-of-life impairment. Latest research indicates that the brain-gut axis plays a key role in the disorder, and the presence of psychological factors and central processing deficits contribute to symptom severity and disability. Psychological therapies as a whole have demonstrated good efficacy in reducing the severity of IBS symptoms. Cognitive-behavioral therapy (CBT) has been tested most rigorously in multiple randomized controlled trials and consistently demonstrates significant and durable effects on IBS symptoms and quality of life...
2017: Psychology Research and Behavior Management
https://www.readbyqxmd.com/read/28783162/classification-of-common-human-diseases-derived-from-shared-genetic-and-environmental-determinants
#15
Kanix Wang, Hallie Gaitsch, Hoifung Poon, Nancy J Cox, Andrey Rzhetsky
In this study, we used insurance claims for over one-third of the entire US population to create a subset of 128,989 families (481,657 unique individuals). We then used these data to (i) estimate the heritability and familial environmental patterns of 149 diseases and (ii) infer the genetic and environmental correlations for disease pairs from a set of 29 complex diseases. The majority (52 of 65) of our study's heritability estimates matched earlier reports, and 84 of our estimates appear to have been obtained for the first time...
August 7, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28782197/early-life-adversity-epigenetics-and-visceral-hypersensitivity
#16
REVIEW
S Liu, S I Hagiwara, A Bhargava
Abdominal pain is associated with many gastrointestinal dysfunctions, such as irritable bowel syndrome (IBS), functional dyspepsia, and inflammatory bowel disease (IBD). Visceral hypersensitivity is a key reason for development of abdominal pain that presents in these gastrointestinal disorders/diseases. The pathogenesis of visceral hypersensitivity is complex and still far from being fully understood. In animal studies, visceral hypersensitivity has been linked to several early-life adverse (ELA) events. In humans, IBD, functional dyspepsia, and IBS can have adult onset, though the adverse events that lead to visceral hypersensitivity are largely uncharacterized...
September 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28778093/htr3a-and-htr3e-gene-polymorphisms-and-diarrhea-predominant-irritable-bowel-syndrome-risk-evidence-from-a-meta-analysis
#17
Tangming Guan, Ting Li, Weiming Cai, Dong Huang, Peipei Ouyang, Yan Wang, Huayan Chen, Kefeng Wu, Xiaoli Ma
Several studies have reported an association between serotonin receptor type 3 (5-HT3) subunit genes HTR3A (rs1062613) and HTR3E (rs62625044) and diarrhea predominant irritable bowel syndrome (IBS-D). However, the results remain inconclusive and controversial, particularly for the data derived from different ethnicities and genders. Therefore, we performed a meta-analysis to evaluate this association. All eligible case-control studies that met the search criteria were retrieved from multiple databases, and five case-control studies were included for detailed evaluation...
July 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28777367/-antioxidant-anti-inflammatory-and-sedative-effects-of-melatonin-results-of-clinical-trials
#18
REVIEW
D I Burchakov, Yu B Uspenskaya
A literature review of clinical trials and systematic reviews on the antioxidant and anti-inflammatory effects of melatonin is presented. The results of animal studies and recent publications on the effects of melatonin in humans are summarized. Melatonin protects the cardiovascular system from destructive effects of ischemia/reperfusion, when the drug has been timely administered, has a neuroprotective effect in newborns with asphyxia. It is an effective drug in complex treatment of irritable bowel syndrome and inflammatory bowel diseases (Crohn's disease and ulcerative colitis)...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28774868/role-of-g-protein-coupled-receptors-microrna-interactions-in-gastrointestinal-pathophysiology
#19
Ivy Ka Man Law, David Miguel Padua, Dimitrios Ilopoulos, Charalabos Pothoulakis
G protein-coupled receptors (GPCRs) make up the largest transmembrane receptor superfamily in the human genome and are expressed in nearly all gastrointestinal (GI) cell types. Coupling of GPCRs and their respective ligands activates various phosphotransferase in the cytoplasm, and thus, activation of GPCR signaling in intestine regulates many cellular and physiological processes. Studies in microRNAs (miRNAs) demonstrate that they represent critical epigenetic regulators of different pathophysiologic responses in different organs and cell types in humans and animals...
August 3, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28774781/estrogen-signaling-deregulation-related-with-local-immune-response-modulation-in-irritable-bowel-syndrome
#20
REVIEW
Damian Jacenik, Adam I Cygankiewicz, Jakub Fichna, Anna Mokrowiecka, Ewa Małecka-Panas, Wanda M Krajewska
The etiology and pathogenesis underlying irritable bowel syndrome (IBS), a common gastrointestinal disorder are still unclear. Cumulating data suggest dysregulation of inflammatory and immune response pathways and changes of epithelial barrier function. The role of estrogens albeit varied, in responses of immune system is well documented. The aim of this study was to investigate estrogen receptors engagment in IBS subtypes, i.e. constipation predominant (IBS-C) and diarrhea predominant (IBS-D). Furthermore, we analyzed whether estrogen signaling is accompanied by alteration in expression of pro- and anti-inflammatory cytokines and microRNAs that can regulate among others genes involved in immune responses...
July 31, 2017: Molecular and Cellular Endocrinology
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