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Nsi-189

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https://www.readbyqxmd.com/read/27528461/a-phase-1b-randomized-double-blind-placebo-controlled-multiple-dose-escalation-study-of-nsi-189-phosphate-a-neurogenic-compound-in-depressed-patients
#1
M Fava, K Johe, L Ereshefsky, L G Gertsik, B A English, J A Bilello, L M Thurmond, J Johnstone, B C Dickerson, N Makris, B B Hoeppner, M Flynn, D Mischoulon, G Kinrys, M P Freeman
No abstract text is available yet for this article.
October 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/26643541/a-phase-1b-randomized-double-blind-placebo-controlled-multiple-dose-escalation-study-of-nsi-189-phosphate-a-neurogenic-compound-in-depressed-patients
#2
M Fava, K Johe, L Ereshefsky, L G Gertsik, B A English, J A Bilello, L M Thurmond, J Johnstone, B C Dickerson, N Makris, B B Hoeppner, M Flynn, D Mischoulon, G Kinrys, M P Freeman
We wanted to examine tolerability and efficacy of NSI-189, a benzylpiperizine-aminiopyridine neurogenic compound for treating major depressive disorder (MDD). This was a Phase 1B, double blind, randomized, placebo controlled, multiple-dose study with three cohorts. The first cohort received 40 mg q.d. (n=6) or placebo (n=2), the second cohort 40 mg b.i.d. (n=6) or placebo (n=2), and the third cohort 40 mg t.i.d. (n=6) or placebo (n=2). Twenty-four patients with MDD were recruited, with the diagnosis and severity confirmed through remote interviews...
October 2016: Molecular Psychiatry
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