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https://www.readbyqxmd.com/read/29682116/treatment-outcomes-of-anticoagulant-therapy-and-temporary-inferior-vena-cava-filter-implantation-for-pregnancy-complicated-by-venous-thrombosis
#1
Nobuhiro Hara, Takamichi Miyamoto, Junji Yamaguchi, Takamasa Iwai, Sadahiro Hijikata, Keita Watanabe, Yuichiro Sagawa, Ryo Masuda, Ryoichi Miyazaki, Naoyuki Miwa, Masahiro Sekigawa, Tetsuo Yamaguchi, Yasutoshi Nagata, Toshihiro Nozato, Orie Kobayashi, Satoshi Umezawa, Toru Obayashi
Objective : Although deep vein thrombosis (DVT) followed by pulmonary thromboembolism (PE) is a critical complication during pregnancy, there have been few reports about its intrapartum management. We evaluated intrapartum management by using a temporary inferior vena cava filter (IVCF) in pregnant women with PE/DVT. Materials and Methods : Eleven women with PE/DVT during pregnancy between January 2004 and December 2016 were included. The patients were hospitalized for intravenous unfractionated heparin infusion after acute PE/DVT onset...
March 25, 2018: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29655806/is-there-a-role-for-intervention-radiology-for-the-treatment-of-lower-limb-deep-vein-thrombosis-in-the-era-of-direct-oral-anticoagulants-a-comprehensive-review
#2
REVIEW
Marco Marietta, Elisa Romagnoli, Benilde Cosmi, Valeria Coluccio, Mario Luppi
Despite recent advances in the treatment of Deep Vein Thrombosis (DVT) provided by Direct Oral Anticoagulants (DOAC), a substantial proportion of lower limb DVT patients will develop some degree of post-thrombotic syndrome (PTS) within 2 years. Systemic thrombolysis, although effective in reducing the risk of PTS and leg ulceration, is associated with a high risk of major bleeding, making it unsuitable for the vast majority of patients. A local approach, aimed at delivering the fibrinolytic drug directly into, or near to, the thrombus surface, is attractive because of the possibility of lowering of the administered drug dose, thus reducing the bleeding risks...
April 11, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29653390/fondaparinux-versus-nadroparin-for-thromboprophylaxis-following-minimally-invasive-esophagectomy-a-randomized-controlled-trial
#3
Jieqiong Song, Lizhen Xuan, Wei Wu, Yaxing Shen, Lijie Tan, Ming Zhong
BACKGROUND: The methodology of thromboprophylaxis post minimally invasive esophagectomy (MIE) is unclear. Thus, we compared the efficacy and safety of fondaparinux and nadroparin on the prophylaxis of venous thromboembolism (VTE) after MIE. MATERIALS AND METHODS: We conducted a randomized, double-blind, treatment-controlled study. Consecutive patients undergoing MIE randomly received a single dose of either nadroparin 2850 AxaIU (Group H) or fondaparinux 2.5 mg (Group F) daily...
April 4, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29650271/effect-of-anticoagulants-on-admission-rates-and-length-of-hospital-stay-for-acute-venous-thromboembolism-a-systematic-review-of-randomized-control-trials
#4
REVIEW
Yongzhe Hong, Sola Mansour, Ghazi Alotaibi, Cynthia Wu, Michael Sean McMurtry
BACKGROUND: There is a paucity of data available on hospitalization and length of stay (LOS) for different anticoagulant therapies. We sought to compare and summarize admission rates and LOS, and describe the frequency of reporting these two outcomes in randomized control trials (RCTs) comparing different anticoagulant therapies for venous thromboembolism (VTE). METHODS: A literature search was conducted from inception to August 15, 2016 on RCTs of anticoagulant therapy for patients with VTE...
May 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29649058/asymptomatic-deep-vein-thrombosis-during-free-flap-concerns-in-free-flap-surgery
#5
Jae-A Jung, Bo Young Park, So-Ra Kang, Min Ji Kim
BACKGROUND: Venous insufficiency is the most frequent cause of failure in free flap reconstruction of the lower extremity. When deep vein thrombosis (DVT) is detected during preoperative assessment of the lower extremity, decisions regarding treatment plans become difficult, and no relevant guidelines regarding surgery and preoperative treatment of patients with DVT who need a free flap transfer are currently available. METHODS: In order to find a relevant guideline in decision-making regarding surgery and preoperative treatment of patients with DVT who require free flap reconstruction, a systematic literature review was conducted searching MEDLINE, PubMed Central, Cochrane, and Embase databases for articles published between 1996 and 2015...
March 30, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29642860/atrophic-inferior-vena-cava-is-a-marker-of-chronicity-of-intra-filter-and-inferior-vena-cava-thrombosis-based-on-ct-findings
#6
Liang Chen, Wanyin Shi, Jianping Gu, Xu He, Wensheng Lou
BACKGROUND: A permanently indwelling filter in the inferior vena cava (IVC) may induce caval thrombosis, which could develop and evolve from an acute to a chronic phase. The differential diagnosis of acute and chronic thromboses determines the treatment strategy. The role of computed tomography (CT) in diagnosing acute and chronic intra-filter and IVC thromboses has not been well established. This retrospective study summarizes the CT signs that indicate acute and chronic phases of intra-filter and IVC thromboses...
April 11, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29618152/altered-plasma-clot-properties-and-trauma-related-venous-thromboembolism-despite-thromboprophylaxis
#7
Sarah Goldman, Paulina Frączek, Krzysztof Szklanny, Elżbieta Papuga-Szela, Andrzej Stanisz, Anetta Undas
BACKGROUND:  Prothrombotic clot phenotype may characterize patients developing deep vein thrombosis (DVT) despite pharmacological thromboprophylaxis. We studied the role of fibrin clot properties and its potential determinants in individuals who experienced DVT after lower limb injury. METHODS:  In a case-control study, we assessed 50 patients who developed DVT despite prophylactic use of low-molecular-weight heparins (the failed thromboprophylaxis group) after a lower limb injury, and three age- and sex-matched control groups, 50 patients each: (1) patients with trauma-related DVT without prior thromboprophylaxis; (2) individuals with unprovoked DVT; (3) patients without history of DVT (the no-DVT controls)...
April 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29613956/optimal-timing-of-initiation-of-thromboprophylaxis-in-spine-trauma-managed-operatively-a-nationwide-propensity-matched-analysis-of-trauma-quality-improvement-program
#8
Muhammad Zeeshan, Muhammad Khan, Terence O'Keeffe, Nina Pollack, Mohammad Hamidi, Narong Kulvatunyou, Joseph V Sakran, Lynn Gries, Bellal Joseph
INTRODUCTION: Patients with spinal trauma are at high-risk for venous-thromboembolism(VTE). Guidelines recommend prophylactic anticoagulation but they are unclear on timing of initiation of thromboprophylaxis. The aim of our study was to assess the impact of early vs late initiation of venous thromboprophylaxis in patients with spinal trauma who underwent operative intervention. METHODS: We performed a 2-year (2013-14) review of patients with isolated spine trauma (S-AIS≥3 and no other injury in another body region with AIS>2) who underwent operative intervention and received thromboprophylaxis post-operatively...
April 2, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29580646/assessment-of-30-day-mortality-and-complication-rates-associated-with-extended-deep-vein-thrombosis-prophylaxis-following-hip-fracture-surgery
#9
Wesley M Durand, Avi D Goodman, Joey P Johnson, Alan H Daniels
BACKGROUND: DVT is a common complication following lower extremity surgery, occurring in up to 60% of patients undergoing hip fracture surgery without postoperative anticoagulation. The risk of fatal PE continues well-beyond two weeks postoperatively, thus extended DVT prophylaxis beyond 14 days may be warranted. This investigation sought to examine the association between prescription of extended DVT prophylaxis and 30-day postoperative complications following hip fracture surgery...
March 19, 2018: Injury
https://www.readbyqxmd.com/read/29570366/therapeutic-approach-for-patients-with-venous-thromboembolism-attended-in-emergency-departments-during-routine-clinical-practice-the-edith-study
#10
Pedro Ruiz-Artacho, Pascual Piñera, Albert Antolin, José Ramón Casal, Marta Sanchez, Coral Suero, Marta Merlo, Jorge Carriel, Mar Genis, Sonia Jimenez
AIM: To analyze treatment at discharge/follow-up of patients diagnosed with venous thromboembolism (VTE) in the emergency department (ED). MATERIALS & METHODS: Ambispective study (50 Spanish centers) of consecutive patients (October-December 2014) with VTE diagnosed in ED. RESULTS: VTE was diagnosed in 775 patients (295 pulmonary embolism [PE] without deep vein thrombosis [DVT], 389 DVT without PE and 91 PE + DVT); 95.5% received anticoagulants (90...
April 2018: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/29566997/-quality-of-care-and-safety-indicators-in-anticoagulated-patients-with-non-valvular-auricular-fibrillation-and-deep-venous-thromboembolic-disease
#11
E Ignacio, J J Mira, F J Campos, E López de Sá, A Lorenzo, F Caballero
OBJECTIVES: To identify and prioritise indicators to assess the quality of care and safety of patients with non-valvular auricular fibrillation (NVAF) and deep vein thrombosis (DVT) treated with anticoagulants. MATERIALS AND METHODS: Using the consensus conference technique, a group of professionals and clinical experts, the determining factors of the NVAF and DVT care process were identified, in order to define the quality and safety criteria. A proposal was made for indicators of quality and safety that were prioritised, taking into account a series of pre-established attributes...
March 19, 2018: Revista de Calidad Asistencial: Organo de la Sociedad Española de Calidad Asistencial
https://www.readbyqxmd.com/read/29549559/no-effectiveness-of-anticoagulants-for-thromboprophylaxis-after-non-major-knee-arthroscopy-a-systemic-review-and-meta-analysis-of-randomized-controlled-trials
#12
REVIEW
Gang Zheng, Qian Tang, Ping Shang, Xiao-Yun Pan, Hai-Xiao Liu
Arthroscopic knee surgery is the most commonly performed orthopedic procedure worldwide and whether thromboprophylaxis should be undertaken after knee arthroscopy is still controversial. To evaluate the efficacy of thromboprophylaxis for deep venous thrombosis (DVT) and venous thromboembolism (VTE) after knee arthroscopic surgery. A meta-analysis was conducted using data from eight randomized trials (4148 patients) to compare thromboprophylaxis with placebo or no prophylactic treatment in patients undergoing knee arthroscopy...
March 16, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29536478/peculiar-laboratory-phenotype-genotype-relationship-due-to-compound-inherited-protein-c-defects-in-a-child-with-severe-venous-thromboembolism
#13
Cristiana Bulato, Elena Campello, Sabrina Gavasso, Sara Maggiolo, Daniela Tormene, Paolo Simioni
A 7-years-old child who developed unprovoked deep vein thrombosis (DVT) and pulmonary embolism (PE) was tested for inherited thrombophilia. Protein C (PC) antigen level (87 %) and PC coagulometric and amidolytic activities (12 % and 11 %, respectively) were consistent with a homozygous PC type IIA phenotype.The patient was carrier of two heterozygous missense mutations causing p.Arg32Cys substitution associated with a type I PC defect ("null allele", from the paternal side) and p.Gly433Ser substitution responsible for a type IIA PC defect (from the maternal side)...
February 2018: Hämostaseologie
https://www.readbyqxmd.com/read/29520700/multidisciplinary-approach-to-the-management-of-patients-with-pulmonary-embolism-and-deep-vein-thrombosis-a-consensus-on-diagnosis-traditional-therapy-and-therapy-with-rivaroxaban
#14
Davide Imberti, Cecilia Becattini, Enrico Bernardi, Giuseppe Camporese, Claudio Cuccia, Francesco Dentali, Damiano Paretti
Despite the availability of updated guidelines for the diagnosis and treatment of venous thromboembolism (VTE), the management of this disorder in clinical practice is often not standardized, given the different degree of compliance with official recommendations by the various involved specialists. The aim of this consensus paper, as a result of a board of experts in thromboembolism, is to define strategies to improve the quality of patients' care and the efficiency of healthcare resources utilization, by means of: (a) analysis of the guidelines for diagnosis and treatment of VTE; (b) analysis of diagnostic and therapeutic algorithms currently used in clinical practice by different specialists; (c) agreement on a common algorithm for diagnosis and treatment of VTE in different clinical settings; (d) definition of the possible role of the new oral anticoagulant agents (NOAC), such as rivaroxaban, based on their potential benefits for both acute and chronic therapy...
March 8, 2018: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/29518515/malignancy-does-not-affect-outcomes-of-pharmacomechanical-thrombolysis-in-acute-symptomatic-iliofemoral-deep-vein-thrombosis
#15
William J Yoon, Pegge Halandras, Bernadette Aulivola, Paul Crisostomo
INTRODUCTION & OBJECTIVES: Cancer patients demonstrate increased risk for venous thromboembolism (VTE), VTE recurrence, and anticoagulation-associated bleeding. Pharmacomechanical thrombolysis and thrombectomy (PMT) improves venous patency, venous valve function, and quality of life in patients with acute iliofemoral deep venous thrombosis (DVT). It remains unknown whether pharmacomechanical thrombolysis can be used safely in patients with active cancer. We hypothesized that perioperative and short-term outcomes of pharmacomechanical iliofemoral DVT thrombolysis would not differ between patients with cancer and those without cancer...
March 5, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29518508/ilio-iliac-arteriovenous-fistulae-an-unusual-diagnosis-with-an-even-more-unusual-clinical-presentation
#16
A Coelho, P Brandão, M Lobo, I Lojo, A Canedo
INTRODUCTION: Major pelvic Ilio-Iliac arteriovenous fistula (AVF) is an exceedingly rare diagnosis with only a few described cases in the literature, most of them related to congenital defects or trauma. In this case report, we aim to present a case of an ilio-iliac AVF with an atypical clinical presentation. CASE REPORT: The patient is a 77-year-old women, with a relevant medical history of a temporally remote hysterectomy. She developed an exuberant unilateral right leg oedema and was diagnosed with a femoro-iliac deep vein thrombosis (DVT) and started on anticoagulation and daily use of elastic compression stockings...
March 5, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29515698/management-of-pulmonary-thromboembolism-based-on-severity-and-vulnerability-to-thrombolysis
#17
Wakako Fukuda, Satoshi Taniguchi, Ikuo Fukuda, Mari Chiyoya, Chikashi Aoki, Norihiro Kondo, Kaoru Hattori, Kazuyuki Daitoku, Ryosuke Kowatari, Masahito Minakawa, Yasuyuki Suzuki
Background : The incidence of pulmonary thromboembolism has been considered rare in Japan. However, its occurrence has been increasing because of westernized lifestyle and diet, increased diagnostic technique, and recognition of this disease. Method : Between January 2003 and September 2014, 179 patients were treated for pulmonary thromboembolism. We classified these patients into 3 groups; Massive (n=35), Sub-massive (n=29) and Nonmassive (n=115) and retrospectively reviewed the treatment options and the outcome...
December 25, 2017: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29505014/development-of-a-postoperative-occlusive-thrombus-at-the-site-of-an-implanted-inferior-vena-cava-filter-a-case-report
#18
Ayako Kukida, Yasushi Takasaki, Mio Nakata, Tasuku Nishihara, Sakiko Kitamura, Sonoko Fujii, Yuji Watanabe, Toshihiro Yorozuya
RATIONALE: Although an inferior vena cave (IVC) filter is placed to prevent fatal pulmonary embolism (PE), several complications associated with an IVC filter have been reported. We describe a case with symptomatic PE, of which the origin was an occlusive IVC thrombus that developed from the placement of an IVC filer after a laparoscopy-assisted total gastrectomy (LATG). PATIENT CONCERNS: A 71-year-old man underwent LATG under general anesthesia alone. He had an IVC filter implanted 13 years ago...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29503557/the-clinical-course-of-symptomatic-deep-vein-thrombosis-after-3-months-of-anticoagulant-therapy-using-fondaparinux-edoxaban-or-fondaparinux-vitamin-k-antagonist
#19
Kazuhiro Shimizu, Takuo Iiduka, Shuji Sato, Hajime Kiyokawa, Takahiro Nakagami, Hiroshi Mikamo, Masayo Kawazoe, Mao Takahashi, Mahito Noro
Background: For the management of venous thromboembolism (VTE), providing anticoagulant therapy within the therapeutic range has been a major challenge, as conventional therapy with unfractionated heparin (UFH) and vitamin K antagonist (VKA) requires frequent laboratory monitoring and dose adjustment. Recently, fondaparinux and edoxaban are being used as beneficial alternatives to UFH and VKA. Methods: We evaluated the clinical course of symptomatic deep vein thrombosis (DVT) in patients who received the 3-month anticoagulation therapy with fondaparinux/edoxaban (Group A; n=40) in comparison with the findings from our previous experience of patients who received the fondaparinux/VKA combination (Group B; n=33)...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29498571/the-role-of-preoperative-deep-vein-thrombosis-screening-in-neurooncology
#20
Anmol Pandey, Bhaskar Thakur, Florence Hogg, Christian Brogna, Jamie Logan, Roopen Arya, Richard Gullan, Ranjeev Bhangoo, Keyoumars Ashkan
OBJECTIVE Venous thromboembolism (VTE) is a major cause of morbidity in patients undergoing neurosurgical intervention. The authors postulate that the introduction of a routine preoperative deep vein thrombosis (DVT) screening protocol for patients undergoing neurosurgical intervention for brain tumors would result in a more effective diagnosis of DVT in this high-risk subgroup, and subsequent appropriate management of the condition would reduce pulmonary embolism (PE) rates and improve patient outcomes. METHODS The authors conducted a prospective study of 115 adult patients who were undergoing surgical intervention for a brain tumor...
March 2, 2018: Journal of Neurosurgery
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