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https://www.readbyqxmd.com/read/28066603/characteristics-of-cardiothoracic-surgeons-practicing-at-the-top-ranked-us-institutions
#1
Carlo Maria Rosati, Leonidas G Koniaris, Daniela Molena, David Blitzer, Katherine W Su, Mohammad Tahboub, Panos N Vardas, Leonard N Girardi, Mario Gaudino
BACKGROUND: We aimed to determine which factors distinguish cardiothoracic (CT) surgeons practicing at the top-ranked US institutions from their peers. METHODS: Using online resources, we collected demographics, training information and academic metrics of 694 cardiac (n=489; 70%) and thoracic (n=205; 30%) surgeons practicing at 57 preeminent US institutions, including those with the highest US News & World Report ranking ("top CT centers"). RESULTS: Two hundred and ninety-nine (43...
November 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28048165/su-f-j-60-impact-of-dir-method-on-treatment-dose-wrapping
#2
A Qin, J Liang, J Zhu, X Ding, E Castillo, T Guerrero, D Yan
PURPOSE: To investigate clinical relevant discrepancy between doses wrapped by pure image and biomechanical model based deformable registration (DIR). METHODS: 12 patients, each with a CT pair, were included (5 H&N, 5 Prostate and 2 Lung). A research DIR tool (ADMRIE) was utilized for image based DIR (IMG-DIR). To assure organ matching, contour constrain was applied for prostate patients. Tetrahedron meshes were generated for organs (parotid, bladder, rectum and lung)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28033485/acculturation-needs-of-pediatric-international-medical-graduates-a-qualitative-study
#3
Amanda D Osta, Michelle M Barnes, Regina Pessagno, Alan Schwartz, Laura E Hirshfield
: Phenomenon: International medical graduates (IMGs) play a key role in host countries' health systems but face unique challenges, which makes effective, tailored support for IMGs essential. Prior literature describing the acculturation needs of IMGs focused primarily on communication content and style. We conducted a qualitative study to explore acculturation that might be specific to IMG residents who care for children. APPROACH: In a study conducted from November 2011 to April 2012, we performed four 90-minute semistructured focus groups with 26 pediatric IMG residents from 12 countries...
December 29, 2016: Teaching and Learning in Medicine
https://www.readbyqxmd.com/read/28031610/the-need-for-a-comprehensive-medication-safety-module-in-medical-education
#4
Sujith John Chandy
OBJECTIVE: A rising number of medicines and minimal emphasis on rational prescribing in the medical curriculum may compromise medication safety. There is no focused module in the curriculum dealing with factors affecting safety such as quality, medicines management, rational use, and approach to adverse effects. Creating awareness of these issues would hopefully plant a seed of safe prescribing and encourage pharmacovigilance. A study was therefore done to determine the need for such a module...
October 2016: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/27997264/decrease-in-ionized-and-total-magnesium-blood-concentrations-in-endurance-athletes-following-an-exercise-bout-restores-within-hours-potential-consequences-for-monitoring-and-supplementation
#5
Rieneke Terink, Michael G J Balvers, Maria T Hopman, Renger F Witkamp, Marco Mensink, Jacqueline M T Klein Gunnewiek
Magnesium is essential for optimal sport performance, generating an interest to monitor its status in athletes. However, before measuring magnesium status in blood could become routine, more insight into its diurnal fluctuations and effects of exercise itself is necessary. Therefore, we measured the effect of an acute bout of exercise on ionized (iMg) and total plasma magnesium (tMg) in blood obtained from 18 healthy well-trained endurance athletes (age, 31.1 ± 8.1 yr.; VO2max, 50.9 ± 7.5 ml/kg/min) at multiple time points, and compared this with a resting situation...
December 20, 2016: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/27903896/img-abc-new-features-for-bacterial-secondary-metabolism-analysis-and-targeted-biosynthetic-gene-cluster-discovery-in-thousands-of-microbial-genomes
#6
Michalis Hadjithomas, I-Min A Chen, Ken Chu, Jinghua Huang, Anna Ratner, Krishna Palaniappan, Evan Andersen, Victor Markowitz, Nikos C Kyrpides, Natalia N Ivanova
Secondary metabolites produced by microbes have diverse biological functions, which makes them a great potential source of biotechnologically relevant compounds with antimicrobial, anti-cancer and other activities. The proteins needed to synthesize these natural products are often encoded by clusters of co-located genes called biosynthetic gene clusters (BCs). In order to advance the exploration of microbial secondary metabolism, we developed the largest publically available database of experimentally verified and predicted BCs, the Integrated Microbial Genomes Atlas of Biosynthetic gene Clusters (IMG-ABC) (https://img...
January 4, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/27903252/shifting-tides-in-the-emigration-patterns-of-canadian-physicians-to-the-united-states-a-cross-sectional-secondary-data-analysis
#7
Thomas R Freeman, Stephen Petterson, Sean Finnegan, Andrew Bazemore
BACKGROUND: The relative ease of movement of physicians across the Canada/US border has led to what is sometimes referred to as a 'brain drain' and previous analysis estimated that the equivalent of two graduating classes from Canadian medical schools were leaving to practice in the US each year. Both countries fill gaps in physician supply with international medical graduates (IMGs) so the movement of Canadian trained physicians to the US has international ramifications. Medical school enrolments have been increased on both sides of the border, yet there continues to be concerns about adequacy of physician human resources...
December 1, 2016: BMC Health Services Research
https://www.readbyqxmd.com/read/27888178/perceived-causes-of-differential-attainment-in-uk-postgraduate-medical-training-a-national-qualitative-study
#8
Katherine Woolf, Antonia Rich, Rowena Viney, Sarah Needleman, Ann Griffin
OBJECTIVES: Explore trainee doctors' experiences of postgraduate training and perceptions of fairness in relation to ethnicity and country of primary medical qualification. DESIGN: Qualitative semistructured focus group and interview study. SETTING: Postgraduate training in England (London, Yorkshire and Humber, Kent Surrey and Sussex) and Wales. PARTICIPANTS: 137 participants (96 trainees, 41 trainers) were purposively sampled from a framework comprising: doctors from all stages of training in general practice, medicine, obstetrics and gynaecology, psychiatry, radiology, surgery or foundation, in 4 geographical areas, from white and black and minority ethnic (BME) backgrounds, who qualified in the UK and abroad...
November 25, 2016: BMJ Open
https://www.readbyqxmd.com/read/27876102/structural-functional-brain-changes-in-depressed-patients-during-and-after-electroconvulsive-therapy
#9
Antoine Yrondi, Patrice Péran, Anne Sauvaget, Laurent Schmitt, Christophe Arbus
OBJECTIVES: Electroconvulsive therapy (ECT) is a non-pharmacological treatment that is effective in treating severe and treatment-resistant depression. Although the efficacy of ECT has been demonstrated to treat major depressive disorder (MDD), the brain mechanisms underlying this process remain unclear. Structural-functional changes occur with the use of ECT as a treatment for depression based on magnetic resonance imaging (MRI). For this reason, we have tried to identify the changes that were identified by MRI to try to clarify some operating mechanisms of ECT...
November 23, 2016: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27852927/evolution-of-trnaphe-img2-methyltransferases-involved-in-the-biosynthesis-of-wyosine-derivatives-in-archaea
#10
Jaunius Urbonavičius, Rasa Rutkienė, Anželika Lopato, Daiva Tauraitė, Jonita Stankevičiūtė, Agota Aučynaitė, Laura Kaliniene, Herman van Tilbeurgh, Rolandas Meškys
Tricyclic wyosine derivatives are found at position 37 of eukaryotic and archaeal tRNA(Phe) In Archaea, the intermediate imG-14 is targeted by three different enzymes that catalyze the formation of yW-86, imG, and imG2. We have suggested previously that a peculiar methyltransferase (aTrm5a/Taw22) likely catalyzes two distinct reactions: N(1)-methylation of guanosine to yield m(1)G; and C(7)-methylation of imG-14 to yield imG2. Here we show that the recombinant aTrm5a/Taw22-like enzymes from both Pyrococcus abyssi and Nanoarchaeum equitans indeed possess such dual specificity...
December 2016: RNA
https://www.readbyqxmd.com/read/27821527/left-right-analysis-of-mammary-gland-development-in-retinoid-x-receptor-%C3%AE-mice
#11
Jacqulyne P Robichaux, John W Fuseler, Shrusti S Patel, Steven W Kubalak, Adam Hartstone-Rose, Ann F Ramsdell
Left-right (L-R) differences in mammographic parenchymal patterns are an early predictor of breast cancer risk; however, the basis for this asymmetry is unknown. Here, we use retinoid X receptor alpha heterozygous null (RXRα(+/-)) mice to propose a developmental origin: perturbation of coordinated anterior-posterior (A-P) and L-R axial body patterning. We hypothesized that by analogy to somitogenesis-in which retinoic acid (RA) attenuation causes anterior somite pairs to develop L-R asynchronously-that RA pathway perturbation would likewise result in asymmetric mammary development...
December 19, 2016: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/27799466/img-vr-a-database-of-cultured-and-uncultured-dna-viruses-and-retroviruses
#12
David Paez-Espino, I-Min A Chen, Krishna Palaniappan, Anna Ratner, Ken Chu, Ernest Szeto, Manoj Pillay, Jinghua Huang, Victor M Markowitz, Torben Nielsen, Marcel Huntemann, T B K Reddy, Georgios A Pavlopoulos, Matthew B Sullivan, Barbara J Campbell, Feng Chen, Katherine McMahon, Steve J Hallam, Vincent Denef, Ricardo Cavicchioli, Sean M Caffrey, Wolfgang R Streit, John Webster, Kim M Handley, Ghasem H Salekdeh, Nicolas Tsesmetzis, Joao C Setubal, Phillip B Pope, Wen-Tso Liu, Adam R Rivers, Natalia N Ivanova, Nikos C Kyrpides
Viruses represent the most abundant life forms on the planet. Recent experimental and computational improvements have led to a dramatic increase in the number of viral genome sequences identified primarily from metagenomic samples. As a result of the expanding catalog of metagenomic viral sequences, there exists a need for a comprehensive computational platform integrating all these sequences with associated metadata and analytical tools. Here we present IMG/VR (https://img.jgi.doe.gov/vr/), the largest publicly available database of 3908 isolate reference DNA viruses with 264 413 computationally identified viral contigs from >6000 ecologically diverse metagenomic samples...
January 4, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/27796642/genomic-analysis-of-the-multi-drug-resistant-clinical-isolate-myroides-odoratimimus-pr63039
#13
Shaohua Hu, Tao Jiang, Yajun Zhou, Desong Ming, Hongzhi Gao, Mingxi Wang
Myroides odoratimimus (M. odoratimimus) has been gradually implicated as an important nosocomial pathogen that poses a serious health threat to immunocompromised patients owing to its multi-drug resistance. However, the resistance mechanism is currently unclear. To clarify the antibiotic resistance and infectivity mechanisms of M. odoratimimus, whole genome sequencing was performed on the multi-drug-resistant M. odoratimimus strain PR63039. The genome sequence was completed with single molecule real-time (SMRT) technologies...
October 28, 2016: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/27794040/genomes-online-database-gold-v-6-data-updates-and-feature-enhancements
#14
Supratim Mukherjee, Dimitri Stamatis, Jon Bertsch, Galina Ovchinnikova, Olena Verezemska, Michelle Isbandi, Alex D Thomas, Rida Ali, Kaushal Sharma, Nikos C Kyrpides, T B K Reddy
The Genomes Online Database (GOLD) (https://gold.jgi.doe.gov) is a manually curated data management system that catalogs sequencing projects with associated metadata from around the world. In the current version of GOLD (v.6), all projects are organized based on a four level classification system in the form of a Study, Organism (for isolates) or Biosample (for environmental samples), Sequencing Project and Analysis Project. Currently, GOLD provides information for 26 117 Studies, 239 100 Organisms, 15 887 Biosamples, 97 212 Sequencing Projects and 78 579 Analysis Projects...
January 4, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/27777690/how-residents-say-they-learn-a-national-multi-specialty-survey-of-first-and-second-year-residents
#15
DeWitt C Baldwin, Steven R Daugherty
Relatively little is known about how, from whom, and under what conditions residents say they most effectively learn. We examined the relationships between residents' self-reported ratings of 11 different sources of learning and a number of empirical variables, using a national, random sample of postgraduate year (PGY) 1 and PGY-2 residents in the 1998-1999 training year. Residents were surveyed by mail. Completed surveys were received from 64.2% of 5616 residents contacted. The most often reported sources of learning were other residents and attending physicians...
October 2016: Journal of Graduate Medical Education
https://www.readbyqxmd.com/read/27744073/does-decorin-protect-neuronal-tissue-via-its-antioxidant-and-antiinflammatory-activity-from-traumatic-brain-injury-an-experimental-study
#16
Rafet Özay, Erhan Türkoğlu, Bora Gürer, Habibullah Dolgun, Oya Evirgen, Berrin İmge Ergüder, Nazlı Hayırlı, Levent Gürses, Zeki Şekerci, Erdal Reşit Yılmaz
BACKGROUND: The development of secondary brain injury via oxidative stress after traumatic brain injury (TBI) is well known. Decorin inactivates Transforming growth factor-β1 (TGF-β1), complement system (CS) and Tumor necrosis factor-α (TNF-α) which are related the oxidative stress and apoptosis. Consequently, the aim of the present study was to evaluate the role of Decorin (DC) on TBI. METHODS: A total of 24 male rats were used and divided into four groups as follows; control, trauma, DC, and methylprednisolone (MP)...
October 12, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27738135/img-m-integrated-genome-and-metagenome-comparative-data-analysis-system
#17
I-Min A Chen, Victor M Markowitz, Ken Chu, Krishna Palaniappan, Ernest Szeto, Manoj Pillay, Anna Ratner, Jinghua Huang, Evan Andersen, Marcel Huntemann, Neha Varghese, Michalis Hadjithomas, Kristin Tennessen, Torben Nielsen, Natalia N Ivanova, Nikos C Kyrpides
The Integrated Microbial Genomes with Microbiome Samples (IMG/M: https://img.jgi.doe.gov/m/) system contains annotated DNA and RNA sequence data of (i) archaeal, bacterial, eukaryotic and viral genomes from cultured organisms, (ii) single cell genomes (SCG) and genomes from metagenomes (GFM) from uncultured archaea, bacteria and viruses and (iii) metagenomes from environmental, host associated and engineered microbiome samples. Sequence data are generated by DOE's Joint Genome Institute (JGI), submitted by individual scientists, or collected from public sequence data archives...
January 4, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/27688874/medical-education-in-israel-2016-five-medical-schools-in-in-a-period-of-transition
#18
Shmuel Reis, Jacob Urkin, Rachel Nave, Rosalie Ber, Amitai Ziv, Orit Karnieli-Miller, Dafna Meitar, Peter Gilbey, Dror Mevorach
ABSTRACT: We reviewed the existing programs for basic medical education (BME) in Israel as well as their output, since they are in a phase of reassessment and transition. The transition has been informed, in part, by evaluation in 2014 by an International Review Committee (IRC). The review is followed by an analysis of its implications as well as the emergent roadmap for the future. The review documents a trend of modernizing, humanizing, and professionalizing Israeli medical education in general, and BME in particular, independently in each of the medical schools...
2016: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/27663453/respiratory-self-gated-3d-ute-for-lung-imaging-in-small-animal-mri
#19
Marta Tibiletti, Andrea Bianchi, Åsmund Kjørstad, Stefan Wundrak, Detlef Stiller, Volker Rasche
PURPOSE: To investigate retrospective respiratory gating of three-dimensional ultrashort echo time (3D UTE) lung acquisition in free-breathing rats using k-space center self gating signal (DC-SG) and 3D image-based SG (3D-Img-SG). METHODS: Seven rats were investigated with a quasi-random 3D UTE protocol. Low-resolution time-resolved sliding-window images were reconstructed with a 3D golden-angle radial sparse parallel (GRASP) reconstruction to extract a 3D-Img-SG signal, whereas DC-SG was extracted from the center of k-space...
September 23, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27628719/supporting-international-medical-graduates-transition-to-their-host-country-realist-synthesis
#20
REVIEW
Amelia Kehoe, John McLachlan, Jane Metcalf, Simon Forrest, Madeline Carter, Jan Illing
CONTEXT: Many health services and systems rely on the contribution of international medical graduates (IMGs) to the workforce. However, concern has grown around their regulation and professional practice. There is a need, in the absence of strong evidence and a robust theoretical base, for a deeper understanding of the efficacy of interventions used to support IMGs' transition to their host countries. This study seeks to explore and synthesise evidence relating to interventions developed for IMGs...
October 2016: Medical Education
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