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https://www.readbyqxmd.com/read/29754837/effects-of-exercise-on-gait-and-motor-imagery-in-people-with-parkinson-disease-and-freezing-of-gait
#1
Peter S Myers, Marie E McNeely, Kristen A Pickett, Ryan P Duncan, Gammon M Earhart
INTRODUCTION: Exercise improves gait in Parkinson disease (PD), but whether exercise differentially affects people with PD with (freezers) and without freezing of gait (non-freezers) remains unclear. This study examines exercise's effects on gait performance, neural correlates related to these effects, and potential neural activation differences between freezers and non-freezers during motor imagery (MI) of gait. METHODS: Thirty-seven participants from a larger exercise intervention completed behavioral assessments and functional magnetic resonance imaging (fMRI) scans before and after a 12-week exercise intervention...
May 8, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29740698/meeting-report-31st-international-mammalian-genome-conference-mammalian-genetics-and-genomics-from-molecular-mechanisms-to-translational-applications
#2
REVIEW
Gabriela Sánchez-Andrade, Jacob Moskowitz, Selene Howe, Teresa M Gunn
High on the Heidelberg hills, inside the Advanced Training Centre of the European Molecular Biology Laboratory (EMBL) campus with its unique double-helix staircase, scientists gathered for the EMBL conference "Mammalian Genetics and Genomics: From Molecular Mechanisms to Translational Applications," organized in cooperation with the International Mammalian Genome Society (IMGS) and the Mouse Molecular Genetics (MMG) group. The conference attracted 205 participants from 30 countries, representing 6 of the 7 continents-all except Antarctica...
May 8, 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/29686763/international-medical-graduates-in-the-us-physician-workforce-and-graduate-medical-education-current-and-historical-trends
#3
Awad A Ahmed, Wei-Ting Hwang, Charles R Thomas, Curtiland Deville
Background : Data show that international medical graduates (IMGs), both US and foreign born, are more likely to enter primary care specialties and practice in underserved areas. Comprehensive assessments of representation trends for IMGs in the US physician workforce are limited. Objective : We reported current and historical representation trends for IMGs in the graduate medical education (GME) training pool and US practicing physician workforce. Methods : We compared representation for the total GME and active practicing physician pools with the 20 largest residency specialties...
April 2018: Journal of Graduate Medical Education
https://www.readbyqxmd.com/read/29655937/the-left-inferior-frontal-gyrus-a-neural-crossroads-between-abstract-and-concrete-knowledge
#4
Pasquale Anthony Della Rosa, Eleonora Catricalà, Matteo Canini, Gabriella Vigliocco, Stefano F Cappa
Evidence from both neuropsychology and neuroimaging suggests that different types of information are necessary for representing and processing concrete and abstract word meanings. Both abstract and concrete concepts, however, conjointly rely on perceptual, verbal and contextual knowledge, with abstract concepts characterized by low values of imageability (IMG) (low sensory-motor grounding) and low context availability (CA) (more difficult to contextualize). Imaging studies supporting differences between abstract and concrete concepts show a greater recruitment of the left inferior frontal gyrus (LIFG) for abstract concepts, which has been attributed either to the representation of abstract-specific semantic knowledge or to the request for more executive control than in the case of concrete concepts...
April 12, 2018: NeuroImage
https://www.readbyqxmd.com/read/29610275/inflammation-induced-iron-transport-and-metabolism-by-brain-microglia
#5
Ryan C McCarthy, Jose Carlo Sosa, Andrew M Gardeck, Andrew S Baez, Chih-Hao Lee, Marianne Wessling-Resnick
Microglia are immune cells of the central nervous system and are implicated in brain inflammation. However, how brain microglia modulate transport and metabolism of the essential metal iron in response to pro- and anti-inflammatory environmental cues is unclear. Here, we characterized uptake of transferrin (Tf)-bound iron (TBI) and non-Tf-bound iron (NTBI) by immortalized microglial (IMG) cells. We found that these cells preferentially take up NTBI in response to the proinflammatory stimulus lipopolysaccharide (LPS) or amyloid-beta (Aβ)...
April 2, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29589297/clinical-impact-of-p27-kip1-and-casr-expression-on-primary-hyperparathyroidism
#6
Gozde Sengul Aycicek, Berna Imge Aydogan, Mustafa Sahin, Cevriye Cansız Ersoz, Serpil Dizbay Sak, Nilgun Baskal
We aimed to investigate the expressions of p27 kinase inhibitory protein 1 (p27Kip1 ) and calcium sensing receptor (CaSR) in adenomas and normal parathyroid tissue and to evaluate the relationship of these molecules with clinical and biochemical parameters in primary hyperparathyroidism (PHPT). Fifty-one patients with histopathologically confirmed parathyroid adenomas and 20 patients with normal parathyroid glands (which were removed incidentally during thyroid resection) were included. Immunohistochemical stainings of CaSR and p27Kip1 were performed in surgical specimens...
March 27, 2018: Endocrine Pathology
https://www.readbyqxmd.com/read/29528562/two-enzymes-of-the-acetone-degradation-pathway-of-desulfococcus-biacutus-coenzyme-b-12-dependent-2-hydroxyisobutyryl-coa-mutase-and-3-hydroxybutyryl-coa-dehydrogenase
#7
Jasmin Frey, Fabian Schneider, Thomas Huhn, Dieter Spiteller, Bernhard Schink, David Schleheck
Degradation of acetone by the sulfate-reducing bacterium Desulfococcus biacutus involves an acetone-activation reaction different from that used by aerobic or nitrate-reducing bacteria, because the small energy budget of sulfate-reducing bacteria does not allow for major expenditures into ATP-consuming carboxylation reactions. In the present study, an inducible coenzyme B12 -dependent conversion of 2-hydroxyisobutyryl-CoA to 3-hydroxybutyryl-CoA was demonstrated in cell-free extracts of acetone-grown D. biacutus cells, together with a NAD+ -dependent oxidation of 3-hydroxybutyryl-CoA to acetoacetyl-CoA...
March 12, 2018: Environmental Microbiology Reports
https://www.readbyqxmd.com/read/29525774/organisational-perspectives-on-addressing-differential-attainment-in-postgraduate-medical-education-a-qualitative-study-in-the-uk
#8
Katherine Woolf, Rowena Viney, Antonia Rich, Hirosha Jayaweera, Ann Griffin
OBJECTIVES: To explore how representatives from organisations with responsibility for doctors in training perceive risks to the educational progression of UK medical graduates from black and minority ethnic groups (BME UKGs), and graduates of non-UK medical schools (international medical graduates (IMGs)). To identify the barriers to and facilitators of change. DESIGN: Qualitative semistructured individual and group interview study. SETTING: Postgraduate medical education in the UK...
March 9, 2018: BMJ Open
https://www.readbyqxmd.com/read/29492118/etanercept-prevents-histopathological-damage-after-spinal-cord-injury-in-rats
#9
Askin Esen Hasturk, Cagdas Baran, Erdal Resit Yilmaz, Murat Arikan, Guray Togral, Nazli Hayirli, Berrin Imge Erguder, Oya Evirgen
Background: The aim of our study is to assess the neuroprotective effects of the tumor necrosis factor alpha (TNF-α) inhibitor etanercept (ETA) on histopathological and biochemical changes following spinal cord injury (SCI). Patients and Methods: Fifty-four male Wistar albino rats were randomly assigned into three main groups: The sham, trauma, and ETA group ( n = 18 per group). Each of these groups was further divided into three subgroups ( n = 6 per subgroup) based on the different tissue sampling times postinjury: 1 h, 6 h, and 24 h...
January 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29442915/vapour-phase-dehydration-of-glycerol-to-acrolein-over-wells-dawson-type-h-6-p%C3%A2-w-18-o-62-supported-on-mesoporous-silica-catalysts-prepared-by-supercritical-impregnation
#10
Jianfei Ding, Tianlin Ma, Cuixia Yan, Rong Shao, Wei Xu, Zhi Yun
The H6P2W18O62/MCM-41-SUP was first synthesized using supercritical impregnation as highly efficient catalyst during glycerol conversion reaction. For comparison, the H6P2W18O62/MCM-41 prepared by conventional wet impregnation was also studied. The catalysts were studied using XRD, BET, FTIR, SEM, TEM, pyridine-FTIR, NH3-TPD, TG, ICP and elemental analysis. The characterization results showed that the preparation condition of supercritical carbon dioxide contributed to improve the dispersion of H6P2W18O62 on MCM-41, strengthen the interaction between H6P2W18O62 and MCM-41, increase the thermostability of H6P2W18O62 and enhance the amount of medium and Brønsted acid sites on the catalyst...
April 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29427431/new-insights-into-the-function-and-global-distribution-of-polyethylene-terephthalate-pet-degrading-bacteria-and-enzymes-in-marine-and-terrestrial-metagenomes
#11
Dominik Danso, Christel Schmeisser, Jennifer Chow, Wolfgang Zimmermann, Ren Wei, Christian Leggewie, Xiangzhen Li, Terry Hazen, Wolfgang R Streit
Polyethylene terephthalate (PET) is one of the most important synthetic polymers used today. Unfortunately, the polymers accumulate in nature and to date no highly active enzymes are known that can degrade it at high velocity. Enzymes involved in PET degradation are mainly α- and β-hydrolases, like cutinases and related enzymes (EC 3.1.1). Currently, only a small number of such enzymes are well characterized. In this work, a search algorithm was developed that identified 504 possible PET hydrolase candidate genes from various databases...
April 15, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29399986/2015-rheumatology-workforce-study-the-role-of-graduate-medical-education-in-adult-rheumatology
#12
Marcy B Bolster, Anne R Bass, Jonathan S Hausmann, Chad Deal, Marcia Ditmyer, Kamilah L Greene, Seetha U Monrad, Daniel F Battafarano
OBJECTIVE: Graduate medical education (GME), through fellowship training, plays a critical role in providing new rheumatologists into our workforce and is an essential component when addressing the gap of excess demand for adult rheumatology care. METHODS: Primary and secondary data sources were used to develop an integrated workforce model. Factors specific to new graduates entering the workforce included available and filled fellowship positions, gender shifts, planned work schedules (part-time, full- time), practice settings (academic, non-academic private practice), and number of international medical graduates (IMGs) projecting U...
February 5, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29345718/evaluation-of-the-morphological-characteristic-and-sex-differences-of-sternum-by-multi-detector-computed-tomography
#13
Sibel Ateşoğlu, Mustafa Deniz, Ayşe İmge Uslu
BACKGROUND: Sternum is one of the skeleton parts which have frequently congenital anomalies and variations are commonly used by researchers in determining sex. We evaluated the morphological characteristics and sex-related changes of the sternum in adult individuals using multidetector CT in our study. MATERIALS AND METHODS: 200 adults (103 female and 97 male) aged between 18-87 years were evaluated. Utilizing the morphological characteristics of the sternum based on the multi-slice images; length, width and the thickness of Manubrium, length, width and the thickness of Corpus Sterni, total length of Sternum, Sternal angle, Sternal index, length of the xiphoid process, the thickness of xiphoid process, the number of indents of xiphoid process were measured and a total of 20 parameters were evaluated by adding age, height and weight to these variables...
January 18, 2018: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/29239189/-immunotherapy-in-the-treatment-of-lung-cancer
#14
O Fiala, O Šorejs, M Pešek, J Fínek
BACKGROUND: Lung cancer occupies the leading position of cancer incidence and mortality worldwide, including in the Czech Republic. Despite significant advances in systemic oncology treatments, lung cancer still has the worst prognosis, which is driving the need for innovative therapies and methods to treat this disease. Immunotherapy is a developing area of systemic oncology treatment, which has recently begun to be significantly applied to patients with lung carcinoma. The most useful type of immunotherapy currently employs checkpoint inhibitors, including CTLA-4 inhibitors (ipilimumab and tremelimumab) and PD-1/PD-L1 inhibitors (nivolumab, pembrolizumab, durvalumab, and avelumab)...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29221624/international-medical-graduates-in-nephrology-roles-rules-and-future-risks
#15
Jeffrey S Berns, Muriel Ghosn, Rodolfo R Altamirano
International medical graduates (IMGs) have become an increasingly essential part of many residency and fellowship programs in the United States. IMGs, who may be of either US or non-US citizenship, contribute significantly to the physician workforce across this country, particularly in underserved areas, as well as in their home countries on their return after training. Approximately 65% of nephrology fellows are IMGs, with most of these being non-US citizens. Non-US IMG applications for nephrology fellowship have been declining, exacerbating an ongoing shortage of nephrology trainees...
December 5, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29190402/resident-and-residency-characteristics-associated-with-self-reported-preparedness-for-population-health-management
#16
Erica K Schuster, Lars E Peterson
BACKGROUND AND OBJECTIVES: Population health management (PHM) is an important function of primary care with potential to improve outcomes and decrease costs, but is also among the most difficult strategies to implement in both practices and residency training. Our objective was to determine resident and residency program characteristics associated with graduates' reported preparation to perform PHM. METHODS: We used data from the American Board of Family Medicine (ABFM) Certification Examination registration questionnaire in 2014 and 2015 and ABFM administrative data...
November 2017: Family Medicine
https://www.readbyqxmd.com/read/29187780/the-skull-of-epidolops-ameghinoi-from-the-early-eocene-itabora%C3%A3-fauna-southeastern-brazil-and-the-affinities-of-the-extinct-marsupialiform-order-polydolopimorphia
#17
Robin M D Beck
The skull of the polydolopimorphian marsupialiform Epidolops ameghinoi is described in detail for the first time, based on a single well-preserved cranium and associated left and right dentaries plus additional craniodental fragments, all from the early Eocene (53-50 million year old) Itaboraí fauna in southeastern Brazil. Notable craniodental features of E. ameghinoi include absence of a masseteric process, very small maxillopalatine fenestrae, a prominent pterygoid fossa enclosed laterally by a prominent ectopterygoid crest, an absent or tiny transverse canal foramen, a simple, planar glenoid fossa, and a postglenoid foramen that is immediately posterior to the postglenoid process...
2017: Journal of Mammalian Evolution
https://www.readbyqxmd.com/read/29180562/the-single-graduate-medical-education-gme-accreditation-system-will-change-the-future-of-the-family-medicine-workforce
#18
Michael R Peabody, Thomas R O'Neill, Aimee R Eden, James C Puffer
BACKGROUND: Due to the Accreditation Council for Graduate Medical Education (ACGME)/American Osteopathic Association (AOA) single-accreditation model, the specialty of family medicine may see as many as 150 programs and 500 trainees in AOA-accredited programs seek ACGME accreditation. This analysis serves to better understand the composition of physicians completing family medicine residency training and their subsequent certification by the American Board of Family Medicine. METHODS: We identified residents who completed an ACGME-accredited or dual-accredited family medicine residency program between 2006 and 2016 and cross-tabulated the data by graduation year and by educational background (US Medical Graduate-MD [USMG-MD], USMG-DO, or International Medical Graduate-MD [IMG-MD]) to examine the cohort composition trend over time...
November 2017: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/29163118/semi-automated-anatomical-labeling-and-inter-subject-warping-of-high-density-intracranial-recording-electrodes-in-electrocorticography
#19
Liberty S Hamilton, David L Chang, Morgan B Lee, Edward F Chang
In this article, we introduce img_pipe, our open source python package for preprocessing of imaging data for use in intracranial electrocorticography (ECoG) and intracranial stereo-EEG analyses. The process of electrode localization, labeling, and warping for use in ECoG currently varies widely across laboratories, and it is usually performed with custom, lab-specific code. This python package aims to provide a standardized interface for these procedures, as well as code to plot and display results on 3D cortical surface meshes...
2017: Frontiers in Neuroinformatics
https://www.readbyqxmd.com/read/29129176/composite-reliability-of-workplace-based-assessment-of-international-medical-graduates
#20
Balakrishnan Kichu R Nair, Joyce Mw Moonen-van Loon, Mulavana Parvathy, Brian C Jolly, Cees Pm van der Vleuten
OBJECTIVE: The fitness to practise of international medical graduates (IMGs) is usually evaluated with standardised assessment tests. The performance rather than the competency of practising doctors should, however, be assessed, for which reason workplace-based assessment (WBA) has gained increasing attention. Our aim was to assess the composite reliability of WBA instruments for assessing IMGs. DESIGN AND SETTING: Between June 2010 and April 2015, 142 IMGs were assessed by 99 calibrated assessors; each was assessed in the workplace over 6 months...
November 20, 2017: Medical Journal of Australia
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