keyword
MENU ▼
Read by QxMD icon Read
search

Img

keyword
https://www.readbyqxmd.com/read/28928366/fibromyalgia-and-microglial-tnf-%C3%AE-translational-research-using-human-blood-induced-microglia-like-cells
#1
Masahiro Ohgidani, Takahiro A Kato, Masako Hosoi, Makoto Tsuda, Kohei Hayakawa, Chie Hayaki, Rie Iwaki, Noriaki Sagata, Ryota Hashimoto, Kazuhide Inoue, Nobuyuki Sudo, Shigenobu Kanba
Fibromyalgia is a refractory disease characterized by chronic intractable pain and psychological suffering, the cause of which has not yet been elucidated due to its complex pathology. Activation of immune cells in the brain called microglia has attracted attention as a potential underlying pathological mechanism in chronic pain. Until recently, however, technological and ethical considerations have limited the ability to conduct research using human microglia. To overcome this limitation, we have recently developed a technique to create human-induced microglia-like (iMG) cells from human peripheral blood monocytes...
September 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28916321/analysis-of-resistance-genes-in-pan-resistant-myroides-odoratimimus-clinical-strain-pr63039-using-whole-genome-sequencing
#2
Desong Ming, Qing-Qing Chen, Xiao-Tin Chen
To clarify the antibiotic resistance mechanisms of Myroides odoratimimus, pan-resistant M. odoratimimus strain PR63039 was isolated and its genome sequenced and analyzed. Antimicrobial susceptibility testing was conducted using the Kirby-Bauer disk diffusion method, and the Phoenix-100 Automated Microbiology System with a NMIC/ID-4 panel including aminoglycosides, β-lactams, polypeptides, quinolones, sulfonamides, chloramphenicols, and tetracyclines. Single-molecule real-time whole genome sequencing was conducted using the PacBio RSII system, and genome annotation was performed using RAST and IMG ER...
September 12, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28911863/the-crystal-structure-of-the-pyrococcus-abyssi-mono-functional-methyltransferase-patrm5b
#3
Jialiang Wu, Qian Jia, Saibin Wu, Hui Zeng, Yujie Sun, Caiyan Wang, Ruiguang Ge, Wei Xie
The wyosine hypermodification found exclusively at G37 of tRNA(Phe) in eukaryotes and archaea is a very complicated process involving multiple steps and enzymes, and the derivatives are essential for the maintenance of the reading frame during translation. In the archaea Pyrococcus abyssi, two key enzymes from the Trm5 family, named PaTrm5a and PaTrm5b respectively, start the process by forming N1-methylated guanosine (m(1)G37). In addition, PaTrm5a catalyzes the further methylation of C7 on 4-demethylwyosine (imG-14) to produce isowyosine (imG2) at the same position...
September 11, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28905708/williamwhitmania-taraxaci-gen-nov-sp-nov-a-proteolytic-anaerobe-with-a-novel-type-of-cytology-from-lake-untersee-in-antarctica-description-of-williamwhitmaniaceae-fam-nov-and-emendation-of-the-order-bacteroidales-krieg-2012
#4
Elena V Pikuta, Zhe Lyu, Richard B Hoover, Yuchen Liu, Nisha B Patel, Hans J Busse, Paul A Lawson
The proteolytic bacterium strain A7P-90mT was isolated from Lake Untersee, Antarctica. The anoxic water was collected from a perennially sealed (~100 millennia) glacial ice lake. Gram-stain-negative cells were 0.18-0.3×8.0-25.0 µm in size, straight, slender rods with unusual gliding motility by external, not previously reported, organelles named here as antiae. At the end of stationary phase of growth, spheroplasts were terminally formed and the cells resembled dandelions. After death, cells were helical...
September 14, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28900063/-translational-research-on-neuropsychiatric-disorders-focusing-on-microglia-hypothesis
#5
Takahiro A Kato, Masahiro Ohgidani, Shigenobu Kanba
Microglia-immune cells in the brain-have recently been highlighted to understand the pathophysiology of psychiatric disorders such as schizophrenia, depression, and autism. In this review paper, we introduce the microglia hypothesis for psychiatric disorders. In addition, we introduce our novel translational research approach to psychiatric disorders using microglia-like (iMG) cells directly induced from human blood, these iMG cells can be produced from peripheral monocytes within two weeks using two cytokines: granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-34 (IL-34)...
September 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/28869159/a-comparison-of-objective-assessment-data-for-the-united-states-and-international-medical-graduates-in-a-general-surgery-residency
#6
Francisco Cardenas Lara, Nimesh D Naik, T K Pandian, Becca L Gas, Suzanne Strubel, Rachel Cadeliña, Stephanie F Heller, David R Farley
OBJECTIVE: To compare objective assessment scores between international medical graduates (IMGs) and United States Medical Graduates. Scores of residents who completed a preliminary year, who later matched into a categorical position, were compared to those who matched directly into a categorical position at the Mayo Clinic, Rochester. DESIGN: Postgraduate year (PGY) 1 to 5 residents participate in a biannual multistation, OSCE-style assessment event as part of our surgical training program...
August 28, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28841816/medical-migration-a-qualitative-exploration-of-the-atypical-path-of-japanese-international-medical-graduates
#7
Brian S Heist, Haruka Matsubara Torok
BACKGROUND: International Medical Graduates (IMGs) are commonly understood to move from low to high resource countries with motivations including improved financial situations and cultures of emigration. A presumable exception to the above themes would be the Japanese IMG population. The aim of this study was to develop an understanding of the Japanese IMG experience. METHODS: Using a grounded theory approach, we interviewed 19 Japanese IMGs working in the US and 16 Japanese IMGs working in Japan who had completed US clinical training...
August 25, 2017: Medical Teacher
https://www.readbyqxmd.com/read/28838203/lessons-learned-from-managing-the-planning-and-implementation-of-inactivated-polio-vaccine-introduction-in-support-of-the-polio-endgame
#8
Simona Zipursky, Manish Patel, Margaret Farrell, Alejandro Ramirez Gonzalez, Tasleem Kachra, Yann Folly, Feyrouz Kurji, Chantal Laroche Veira, Emily Wootton, Lee M Hampton
The Immunization Systems Management Group (IMG) was established as a time-limited entity, responsible for the management and coordination of Objective 2 of the Polio Eradication and Endgame Strategic Plan. This objective called for the introduction of at least 1 dose of inactivated polio vaccine (IPV) into the routine immunization programs of all countries using oral polio vaccine (OPV) only. Despite global vaccine shortages, which limited countries' abilities to access IPV in a timely manner, 105 of 126 countries using OPV only introduced IPV within a 2...
July 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28838174/polio-endgame-lessons-learned-from-the-immunization-systems-management-group
#9
Simona Zipursky, Jos Vandelaer, Alan Brooks, Vance Dietz, Tasleem Kachra, Margaret Farrell, Ann Ottosen, John L Sever, Michel J Zaffran
The Immunization Systems Management Group (IMG) was established to coordinate and oversee objective 2 of the Polio Eradication and Endgame Strategic Plan 2013-2018, namely, (1) introduction of ≥1 dose of inactivated poliovirus vaccine in all 126 countries using oral poliovirus vaccine (OPV) only as of 2012, (2) full withdrawal of OPV, starting with the withdrawal of its type 2 component, and (3) using polio assets to strengthen immunization systems in 10 priority countries. The IMG's inclusive, transparent, and partnership-focused approach proved an effective means of leveraging the comparative and complementary strengths of each IMG member agency...
July 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28838169/exceptional-financial-support-for-introduction-of-inactivated-polio-vaccine-in-middle-income-countries
#10
Anne-Line Blankenhorn, Tania Cernuschi, Michel J Zaffran
In May 2012, the World Health Assembly declared the completion of poliovirus eradication a programmatic emergency for global public health and called for a comprehensive polio endgame strategy. The Polio Eradication and Endgame Strategic Plan 2013-2018 was developed in response to this call and demands that all countries using Oral Polio Vaccine (OPV) only introduce at least 1 dose of Inactivated Polio Vaccine (IPV) into routine immunization schedules by the end of 2015. In November 2013, the Board of Gavi (the Vaccine Alliance) approved the provision of support for IPV introduction in the 72 Gavi-eligible countries...
July 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28732315/total-and-ionized-magnesium-testing-in-the-surgical-intensive-care-unit-opportunities-for-improved-laboratory-and-pharmacy-utilization
#11
Daniel Dante Yeh, Nalin Chokengarmwong, Yuchiao Chang, Liyang Yu, Colleen Arsenault, Joseph Rudolf, Elizabeth Lee-Lewandrowski, Kent Lewandrowski
PURPOSE: Ionized fraction (iMg) is the physiologically active form of magnesium (Mg); total Mg may not accurately reflect iMg status. Erroneously "low" Mg levels may result in unnecessary repetitive testing. MATERIALS AND METHODS: From 11/2015 to 01/2016, patients ordered for Mg from a pilot ICU also had iMg tested. Weighted kappa statistic was used to assess agreement between Mg categories (low, normal, high). Predictors of unnecessary repeated Mg testing and repletion using data were explored through logistic regression models using GEE techniques to account for repeated measurements in both bivariate and multivariable analyses...
July 11, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28729125/comparative-effects-of-vitamin-d-and-methylprednisolone-against-ischemia-reperfusion-injury-of-rabbit-spinal-cords
#12
Bora Gürer, Abdullah Karakoç, Pınar Kuru Bektaşoğlu, Hayri Kertmen, Mehmet Ali Kanat, Ata Türker Arıkök, Berrin İmge Ergüder, Mustafa Fevzi Sargon, Özden Çağlar Öztürk, Erhan Çelikoğlu
INTRODUCTION: Recent studies have demonstrated the neuroprotective and immunomodulatory effects of 1,25-dihydroxyvitamin D3 (calcitriol), but no previous study has examined these effects on spinal cord ischemia/reperfusion (I/R) injury. Therefore, the present study aimed to evaluate whether calcitriol protects the spinal cord from I/R injury. METHODS: Rabbits were randomized into four groups of eight animals: group 1 (laparotomy control), group 2 (ischemia control), group 3 (30mg/kg intraperitoneal methylprednisolone at surgery), and group 4 (0...
July 18, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28722477/advances-toward-lsd1-inhibitors-for-cancer-therapy
#13
Xiaoli Fu, Peng Zhang, Bin Yu
LSD1 has become an important biologically validated epigenetic target for cancer therapy since its identification in 2004. LSD1 mediates many cellular signaling pathways and is involved in the initiation and development of cancers. Aberrant overexpression of LSD1 has been observed in different types of cancers, and inactivation by small molecules suppresses cancer cell differentiation, proliferation, invasion and migration. To date, a large number of LSD1 inhibitors have been reported, RG6016, GSK-2879552, INCB059872, IMG-7289 and CC-90011 are currently undergoing clinical assessment for the treatment of acute myeloid leukemia, small-cell lung cancer, etc...
July 2017: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/28721119/educational-challenges-faced-by-international-medical-graduates-in-the-uk
#14
Ahmed Hashim
INTRODUCTION: International medical graduates (IMGs) in the UK constitute approximately one-quarter of the total number of doctors registered in the General Medical Council (GMC). The transition of IMGs into the health care system in the UK is accompanied by significant sociocultural and educational challenges. This study aims to explore the views of IMGs in medical training on the educational challenges they face. METHODS: This study was conducted in the Kent, Surrey and Sussex region in 2015...
2017: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/28715467/dealing-with-foreign-cultural-paradigms-a-systematic-review-on-intercultural-challenges-of-international-medical-graduates
#15
Kerstin Michalski, Nabeel Farhan, Edith Motschall, Werner Vach, Martin Boeker
OBJECTIVES: An increasing number of International Medical Graduates (IMG), who are defined to be physicians working in a country other than their country of origin and training, immigrate to Western countries. In order to ensure safe and high-quality patient care, they have to take medical and language tests. This systematic review aims to (1) collect all empiric research on intercultural communication of IMGs in medical settings, (2) identify and categorize all text passages mentioning intercultural issues in the included studies, and (3) describe the most commonly reported intercultural areas of communication of IMGs...
2017: PloS One
https://www.readbyqxmd.com/read/28689696/implementing-a-systematic-approach-to-improve-governance-and-deployment-of-imaging-codes-in-radiology
#16
Carolina V Guimaraes, Laura A Smith, Jo A Garza, Maria E Blado, Crystal S Lokey, Lane F Donnelly
Unlike medical procedure (Current Procedural Terminology [CPT]) and diagnostic (International Classification of Diseases [ICD]) codes, imaging (IMG) codes are defined at the local, institutional level. IMG codes are used within an organization to define IMG procedures and how they are routed between information systems. Our purpose is to describe the implementation of a reorganization (referred to as the IMG code cleanup) and governance structure deployed at a large children's hospital and the initial effects of that implementation...
June 6, 2017: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/28686293/is-primary-hyperparathyroidism-a-cause-of-endothelial-dysfunction
#17
Sevgi Colak, Berna Imge Aydogan, Asena Gokcay Canpolat, Cansin Tulunay Kaya, Mustafa Sahin, Demet Corapcioglu, Ali Riza Uysal, Rifat Emral
OBJECTIVE: Symptomatic primary hyperparathyroidism (PHPT) is thought to be related to increased cardiovascular morbidity and mortality. In our study, we aimed to investigate endothelial dysfunction and markers of subclinical atherosclerosis in patients with PHPT. Also we aimed to demonstrate the effect of vitamin D supplementation on these parameters. MATERIALS AND METHODS: Twenty-nine patients followed by medical treatment (A), 25 preoperative (B) and 23 postoperative patients with PHPT (C), and 26 normocalcaemic subjects (D) were included...
July 7, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28659172/what-will-make-a-difference-assessing-the-impact-of-policy-and-non-policy-scenarios-on-estimations-of-the-future-gp-workforce
#18
Caroline O M Laurence, Jonathan Karnon
BACKGROUND: Health workforce planning is based on estimates of future needs for and supply of health care services. Given the pipeline time lag for the training of health professionals, inappropriate workforce planning or policies can lead to extended periods of over- or under-supply of health care providers. Often these policy interventions focus on one determinant of supply and do not incorporate other determinants such as changes in population health which impact the need for services...
June 28, 2017: Human Resources for Health
https://www.readbyqxmd.com/read/28640310/spectroscopic-evidence-for-cofactor-substrate-interaction-in-the-radical-sam-enzyme-tyw1
#19
Velavan Kathirvelu, Phanélie Perche-Letuvée, Jean-Marc Latour, Mohamed Atta, Farhad Forouhar, Serge Gambarelli, Ricardo Garcia-Serres
TYW1 is a metalloenzyme involved in the modifications of guanosine 37 of Phe-tRNA of Eukaryota and Archaea. It catalyzes the second step of Wybutosine biosynthesis, which consists of the formation of the tricyclic compound imG-14 from m(1)G using pyruvate and SAM (S-adenosyl-methionine) as co-substrates. Two [4Fe-4S] clusters are needed in the catalytic process. One effects the reductive binding of SAM, which initiates the radical reaction that inserts a C-C moiety into m(1)G. The other [4Fe-4S] cluster binds the pyruvate molecule that provides the C-C motif...
June 22, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28633176/determinants-of-the-5-year-retention-and-rural-location-of-family-physicians-results-from-the-iowa-family-medicine-training-network
#20
Gregory C Nelson, Thomas S Gruca
BACKGROUND AND OBJECTIVES: States are seeking ways to retain primary care physicians trained within their borders. We analyzed the 5-year retention and rural Iowa location decisions for 1,645 graduates of the Iowa Family Medicine Training Network (IFMTN)-eight residency programs (in seven different cities) that are affiliated with the Carver College of Medicine (University of Iowa). METHODS: Data from 1977-2014 includes 98.5% of active graduates. Location in Iowa 5 years after graduation was the dependent variable in a binary logistic regression...
June 2017: Family Medicine
keyword
keyword
84341
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"