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https://www.readbyqxmd.com/read/28732315/total-and-ionized-magnesium-testing-in-the-surgical-intensive-care-unit-opportunities-for-improved-laboratory-and-pharmacy-utilization
#1
Daniel Dante Yeh, Nalin Chokengarmwong, Yuchiao Chang, Liyang Yu, Colleen Arsenault, Joseph Rudolf, Elizabeth Lee-Lewandrowski, Kent Lewandrowski
PURPOSE: Ionized fraction (iMg) is the physiologically active form of magnesium (Mg); total Mg may not accurately reflect iMg status. Erroneously "low" Mg levels may result in unnecessary repetitive testing. MATERIALS AND METHODS: From 11/2015 to 01/2016, patients ordered for Mg from a pilot ICU also had iMg tested. Weighted kappa statistic was used to assess agreement between Mg categories (low, normal, high). Predictors of unnecessary repeated Mg testing and repletion using data were explored through logistic regression models using GEE techniques to account for repeated measurements in both bivariate and multivariable analyses...
July 11, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28729125/comparative-effects-of-vitamin-d-and-methylprednisolone-against-ischemia-reperfusion-injury-of-rabbit-spinal-cords
#2
Bora Gürer, Abdullah Karakoç, Pınar Kuru Bektaşoğlu, Hayri Kertmen, Mehmet Ali Kanat, Ata Türker Arıkök, Berrin İmge Ergüder, Mustafa Fevzi Sargon, Özden Çağlar Öztürk, Erhan Çelikoğlu
INTRODUCTION: Recent studies have demonstrated the neuroprotective and immunomodulatory effects of 1,25-dihydroxyvitamin D3 (calcitriol), but no previous study has examined these effects on spinal cord ischemia/reperfusion (I/R) injury. Therefore, the present study aimed to evaluate whether calcitriol protects the spinal cord from I/R injury. METHODS: Rabbits were randomized into four groups of eight animals: group 1 (laparotomy control), group 2 (ischemia control), group 3 (30mg/kg intraperitoneal methylprednisolone at surgery), and group 4 (0...
July 18, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28722477/advances-toward-lsd1-inhibitors-for-cancer-therapy
#3
Xiaoli Fu, Peng Zhang, Bin Yu
LSD1 has become an important biologically validated epigenetic target for cancer therapy since its identification in 2004. LSD1 mediates many cellular signaling pathways and is involved in the initiation and development of cancers. Aberrant overexpression of LSD1 has been observed in different types of cancers, and inactivation by small molecules suppresses cancer cell differentiation, proliferation, invasion and migration. To date, a large number of LSD1 inhibitors have been reported, RG6016, GSK-2879552, INCB059872, IMG-7289 and CC-90011 are currently undergoing clinical assessment for the treatment of acute myeloid leukemia, small-cell lung cancer, etc...
July 2017: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/28721119/educational-challenges-faced-by-international-medical-graduates-in-the-uk
#4
Ahmed Hashim
INTRODUCTION: International medical graduates (IMGs) in the UK constitute approximately one-quarter of the total number of doctors registered in the General Medical Council (GMC). The transition of IMGs into the health care system in the UK is accompanied by significant sociocultural and educational challenges. This study aims to explore the views of IMGs in medical training on the educational challenges they face. METHODS: This study was conducted in the Kent, Surrey and Sussex region in 2015...
2017: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/28715467/dealing-with-foreign-cultural-paradigms-a-systematic-review-on-intercultural-challenges-of-international-medical-graduates
#5
Kerstin Michalski, Nabeel Farhan, Edith Motschall, Werner Vach, Martin Boeker
OBJECTIVES: An increasing number of International Medical Graduates (IMG), who are defined to be physicians working in a country other than their country of origin and training, immigrate to Western countries. In order to ensure safe and high-quality patient care, they have to take medical and language tests. This systematic review aims to (1) collect all empiric research on intercultural communication of IMGs in medical settings, (2) identify and categorize all text passages mentioning intercultural issues in the included studies, and (3) describe the most commonly reported intercultural areas of communication of IMGs...
2017: PloS One
https://www.readbyqxmd.com/read/28689696/implementing-a-systematic-approach-to-improve-governance-and-deployment-of-imaging-codes-in-radiology
#6
Carolina V Guimaraes, Laura A Smith, Jo A Garza, Maria E Blado, Crystal S Lokey, Lane F Donnelly
Unlike medical procedure (Current Procedural Terminology [CPT]) and diagnostic (International Classification of Diseases [ICD]) codes, imaging (IMG) codes are defined at the local, institutional level. IMG codes are used within an organization to define IMG procedures and how they are routed between information systems. Our purpose is to describe the implementation of a reorganization (referred to as the IMG code cleanup) and governance structure deployed at a large children's hospital and the initial effects of that implementation...
June 6, 2017: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/28686293/is-primary-hyperparathyroidism-a-cause-of-endothelial-dysfunction
#7
Sevgi Colak, Berna Imge Aydogan, Asena Gokcay Canpolat, Cansin Tulunay Kaya, Mustafa Sahin, Demet Corapcioglu, Ali Riza Uysal, Rifat Emral
OBJECTIVE: Symptomatic primary hyperparathyroidism (PHPT) is thought to be related to increased cardiovascular morbidity and mortality. In our study, we aimed to investigate endothelial dysfunction and markers of subclinical atherosclerosis in patients with PHPT. Also we aimed to demonstrate the effect of vitamin D supplementation on these parameters. MATERIALS AND METHODS: Twenty-nine patients followed by medical treatment (A), 25 preoperative (B) and 23 postoperative patients with PHPT (C), and 26 normocalcaemic subjects (D) were included...
July 7, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28659172/what-will-make-a-difference-assessing-the-impact-of-policy-and-non-policy-scenarios-on-estimations-of-the-future-gp-workforce
#8
Caroline O M Laurence, Jonathan Karnon
BACKGROUND: Health workforce planning is based on estimates of future needs for and supply of health care services. Given the pipeline time lag for the training of health professionals, inappropriate workforce planning or policies can lead to extended periods of over- or under-supply of health care providers. Often these policy interventions focus on one determinant of supply and do not incorporate other determinants such as changes in population health which impact the need for services...
June 28, 2017: Human Resources for Health
https://www.readbyqxmd.com/read/28640310/spectroscopic-evidence-for-cofactor-substrate-interaction-in-the-radical-sam-enzyme-tyw1
#9
Velavan Kathirvelu, Phanélie Perche-Letuvée, Jean-Marc Latour, Mohamed Atta, Farhad Forouhar, Serge Gambarelli, Ricardo Garcia-Serres
TYW1 is a metalloenzyme involved in the modifications of guanosine 37 of Phe-tRNA of Eukaryota and Archaea. It catalyzes the second step of Wybutosine biosynthesis, which consists of the formation of the tricyclic compound imG-14 from m(1)G using pyruvate and SAM (S-adenosyl-methionine) as co-substrates. Two [4Fe-4S] clusters are needed in the catalytic process. One effects the reductive binding of SAM, which initiates the radical reaction that inserts a C-C moiety into m(1)G. The other [4Fe-4S] cluster binds the pyruvate molecule that provides the C-C motif...
June 22, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28633176/determinants-of-the-5-year-retention-and-rural-location-of-family-physicians-results-from-the-iowa-family-medicine-training-network
#10
Gregory C Nelson, Thomas S Gruca
BACKGROUND AND OBJECTIVES: States are seeking ways to retain primary care physicians trained within their borders. We analyzed the 5-year retention and rural Iowa location decisions for 1,645 graduates of the Iowa Family Medicine Training Network (IFMTN)-eight residency programs (in seven different cities) that are affiliated with the Carver College of Medicine (University of Iowa). METHODS: Data from 1977-2014 includes 98.5% of active graduates. Location in Iowa 5 years after graduation was the dependent variable in a binary logistic regression...
June 2017: Family Medicine
https://www.readbyqxmd.com/read/28630258/realization-of-entry-to-practice-milestones-by-canadians-who-studied-medicine-abroad-and-other-international-medical-graduates-a-retrospective-cohort-study
#11
Maria Mathews, Rima Kandar, Steve Slade, Yanqing Yi, Sue Beardall, Ivy Bourgeault
BACKGROUND: International medical graduates must realize a series of milestones to obtain full licensure. We examined the realization of milestones by Canadian and non-Canadian graduates of Western or Caribbean medical schools, and Canadian and non-Canadian graduates from other medical schools. METHODS: Using the National IMG Database (data available for 2005-2011), we created 2 cohorts: 1) international medical graduates who had passed the Medical Council of Canada Qualifying Examination Part I between 2005 and 2010 and 2) those who had first entered a family medicine postgraduate program between 2005 and 2009, or had first entered a specialty postgraduate program in 2005 or 2006...
June 19, 2017: CMAJ Open
https://www.readbyqxmd.com/read/28617236/retention-patterns-of-canadians-who-studied-medicine-abroad-and-other-international-medical-graduates
#12
Maria Mathews, Rima Kandar, Steve Slade, Yanqing Yi, Sue Beardall, Ivy Bourgeault
OBJECTIVES: Are Canadians who study abroad (CSAs) more likely to stay in Canada than other international medical graduates (IMGs)? We looked at retention patterns of CSAs and immigrant IMGs who completed post-graduate medical education (PGME) training in Canada to describe the proportion and predictors of those working in Canada and in rural communities in Canada in 2015. METHODS: We linked the National IMG Database to Scott's Medical Database to track the work locations of CSAs and immigrant IMGs in 2015...
May 2017: Healthcare Policy, Politiques de Santé
https://www.readbyqxmd.com/read/28617235/what-do-we-know-and-not-know-about-the-professional-integration-of-international-medical-graduates-imgs-in-canada
#13
Elena Neiterman, Ivy Lynn Bourgeault, Christine L Covell
BACKGROUND: The literature on international medical graduates (IMGs) in Canada is growing, but there is a lack of systematic analysis of the literature. OBJECTIVES: To examine (1) the major themes in academic and grey literature pertaining to professional integration of IMGs in Canada; and (2) the gaps in our knowledge on integration of IMGs. METHODS: This paper is based on the scoping review of academic and grey literature published during 2001-2013 about IMGs in Canada...
May 2017: Healthcare Policy, Politiques de Santé
https://www.readbyqxmd.com/read/28608351/course-of-aggressive-somatotroph-corticotroph-and-mammotroph-tumors-under-temozolomide-report-of-three-cases-and-review-of-the-literature
#14
Berna İmge Aydoğan, Uğur Ünlütürk, Rıfat Emral, Sevim Güllü
Treatment of aggressive pituitary tumors may be challenging. Temozolomide (TMZ) is a promising agent when conventional treatment methods fail. We present three patients with aggressive pituitary tumors with atypical morphology, who were resistant to conventional treatments and treated with TMZ. First case had a somatotroph adenoma, second a corticotroph adenoma, and the third a macroprolactinoma. We also reviewed the literature reporting TMZ efficacy in somatotroph, corticotroph and mammotroph tumors of pituitary...
May 7, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28606105/credentialing-and-retention-of-visa-trainees-in-post-graduate-medical-education-programs-in-canada
#15
Maria Mathews, Rima Kandar, Steve Slade, Yanqing Yi, Sue Beardall, Ivy Bourgeault, Lynda Buske
BACKGROUND: Visa trainees are international medical graduates (IMG) who come to Canada to train in a post-graduate medical education (PGME) program under a student or employment visa and are expected to return to their country of origin after training. We examined the credentialing and retention of visa trainees who entered PGME programs between 2005 and 2011. METHODS: Using the Canadian Post-MD Education Registry's National IMG Database linked to Scott's Medical Database, we examined four outcomes: (1) passing the Medical Council of Canada Qualifying Examination Part 2 (MCCQE2), (2) obtaining a specialty designation (CCFP, FRCPC/SC), and (3) working in Canada after training and (4) in 2015...
June 12, 2017: Human Resources for Health
https://www.readbyqxmd.com/read/28593028/genomics-insights-into-production-of-2-methylisoborneol-and-a-putative-cyanobactin-by-planktothricoides-sp-sr001
#16
Shu Harn Te, Boon Fei Tan, Chek Yin Boo, Janelle Renee Thompson, Karina Yew-Hoong Gin
Planktothricoides is a free-living filamentous cyanobacterium belonging to the order Oscillatoriales and the family Phormidiaceae, capable of forming bloom in fresh and brackish waters. A unicyanobacterial non-axenic culture dominated by Planktothricoides sp. SR001 was obtained from a freshwater reservoir in Singapore. The draft genome presented here is the first tropical freshwater Planktothricoides sp. ever sequenced. The genome of 7.0Mbp contains 5,776 genes predicted using the JGI IMG pipeline. The whole genome sequence allows identification of genes encoding for nitrogen-fixation, accessory photosynthetic pigments and biosynthesis of an off-flavor compound, 2-methylisoborneol, which has been experimentally verified here based on metabolite detection...
2017: Standards in Genomic Sciences
https://www.readbyqxmd.com/read/28554615/utilization-of-quercetin-and-quercetin-glycosides-from-onion-allium-cepa-l-solid-waste-as-an-antioxidant-urease-and-xanthine-oxidase-inhibitors
#17
Shivraj Hariram Nile, Arti Shivraj Nile, Young Soo Keum, Kavita Sharma
This study aimed to determine the flavonol glycosides from onion solid waste (OSW) using HPLC analysis, with antioxidant and enzyme inhibitory activities. We found considerable amount of quercetin-4'-O-monoglucoside (QMG: 254.85), quercetin-3,4'-O-diglucoside (QDG: 162.34), quercetin (Q: 60.44), and isorhamnetin-3-glucoside (IMG: 23.92) (mg/100g) dry weight (DW) of OSW. For OSW, the methanol and ethanol showed the strongest antioxidant activities, followed by ethyl acetate, chloroform, and n-hexane extracts...
November 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28528992/pediatric-ophthalmology-and-strabismus-fellowship-match-outcomes-2000-2015
#18
Gad Dotan, Daniel J Karr, Alex V Levin
PURPOSE: To analyze trends in US pediatric ophthalmology and strabismus (PO&S) Match over the last 16 years. METHODS: We reviewed the PO&S Match outcomes from 2000 to 2015, evaluating the number of participating programs, positions offered, and match rate, comparing it with other subspecialties, and analyzing results of US graduates versus international medical graduates (IMGs). A survey of PO&S program directors explored exposure to PO&S, policies on acceptance of IMGs, fellowship gross salary, job opportunities, and fellow placement after training...
May 18, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28506289/a-preliminary-investigation-to-explore-the-cognitive-resources-of-physicians-experiencing-difficulty-in-training
#19
Fiona Patterson, Fran Cousans, Iain Coyne, Jo Jones, Sheona Macleod, Lara Zibarras
BACKGROUND: Treating patients is complex, and research shows that there are differences in cognitive resources between physicians who experience difficulties, and those who do not. It is possible that differences in some cognitive resources could explain the difficulties faced by some physicians. In this study, we explore differences in cognitive resources between different groups of physicians (that is, between native (UK) physicians and International Medical Graduates (IMG); those who continue with training versus those who were subsequently removed from the training programme); and also between physicians experiencing difficulties compared with the general population...
May 15, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28487430/rna-dependent-cysteine-biosynthesis-in-bacteria-and-archaea
#20
Takahito Mukai, Ana Crnković, Takuya Umehara, Natalia N Ivanova, Nikos C Kyrpides, Dieter Söll
The diversity of the genetic code systems used by microbes on earth is yet to be elucidated. It is known that certain methanogenic archaea employ an alternative system for cysteine (Cys) biosynthesis and encoding; tRNA(Cys) is first acylated with phosphoserine (Sep) by O-phosphoseryl-tRNA synthetase (SepRS) and then converted to Cys-tRNA(Cys) by Sep-tRNA:Cys-tRNA synthase (SepCysS). In this study, we searched all genomic and metagenomic protein sequence data in the Integrated Microbial Genomes (IMG) system and at the NCBI to reveal new clades of SepRS and SepCysS proteins belonging to diverse archaea in the four major groups (DPANN, Euryarchaeota, TACK, and Asgard) and two groups of bacteria ("Candidatus Parcubacteria" and Chloroflexi)...
May 9, 2017: MBio
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