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https://www.readbyqxmd.com/read/29129176/composite-reliability-of-workplace-based-assessment-of-international-medical-graduates
#1
Balakrishnan Kichu R Nair, Joyce Mw Moonen-van Loon, Mulavana Parvathy, Brian C Jolly, Cees Pm van der Vleuten
OBJECTIVE: The fitness to practise of international medical graduates (IMGs) is usually evaluated with standardised assessment tests. The performance rather than the competency of practising doctors should, however, be assessed, for which reason workplace-based assessment (WBA) has gained increasing attention. Our aim was to assess the composite reliability of WBA instruments for assessing IMGs. DESIGN AND SETTING: Between June 2010 and April 2015, 142 IMGs were assessed by 99 calibrated assessors; each was assessed in the workplace over 6 months...
November 20, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/29128927/toll-like-receptors-participate-in-naegleria-fowleri-recognition
#2
Moisés Martínez-Castillo, Leopoldo Santos-Argumedo, José Manuel Galván-Moroyoqui, Jesús Serrano-Luna, Mineko Shibayama
Naegleria fowleri is a protozoan that invades the central nervous system and causes primary amoebic meningoencephalitis. It has been reported that N. fowleri induces an important inflammatory response during the infection. In the present study, we evaluated the roles of Toll-like receptors in the recognition of N. fowleri trophozoites by human mucoepithelial cells, analyzing the expression and production of innate immune response mediators. After amoebic interactions with NCI-H292 cells, the expression and production levels of IL-8, TNF-α, IL-1β, and human beta defensin-2 were evaluated by RT-PCR, ELISA, immunofluorescence, and dot blot assays, respectively...
November 11, 2017: Parasitology Research
https://www.readbyqxmd.com/read/29127889/nitric-oxide-and-arginase-levels-in-peri-implant-tissues-after-delayed-loading
#3
Ceren Gokmenoglu, Nurdan Ozmeric, Caglar Sungur, Raziye Sahin Bildik, Imge Erguder, Serenay Elgun
OBJECTIVE: Nitric oxide (NO) is synthesized from the conversion of L-arginine to L-citrulline by NO synthase (NOS). Arginase can compete with NOS for the common substrate L-arginine, and thus inhibit NO production. NO levels and arginase ezyme might affect the bone remodeling cycle around implants. The aim of this studywas to investigate NO and arginase levels in gingival crevicular fluid (GCF), peri-implant sulcular fluid (PISF), and saliva. MATERIALS AND METHODS: Twenty patients with one or more implants (Straumann(®); Institute Straumann AG, Basel, Switzerland) restored with fixed crown prostheses were included in the study...
October 23, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29056347/addressing-professionalism-social-and-communication-competencies-in-surgical-residency-via-integrated-humanities-workshops-a-pilot-curriculum
#4
Jennifer Colvin, Judith French, Allan Siperstein, Tony R Capizzani, Vikram D Krishnamurthy
OBJECTIVE: We aimed to conduct professionalism and social competencies (PSC) training by integrating humanities into structured workshops, and to assess reception of this curriculum by first-year surgical residents. DESIGN: An IRB-approved, pilot curriculum consisting of 4 interactive workshops for surgical interns was developed. The workshops were scheduled quarterly, often in small group format, and supplemental readings were assigned. Humanities media utilized to illustrate PSC included survival scenarios, reflective writing, television portrayals, and social media...
October 19, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/29045984/results-of-the-2017-national-resident-matching-program%C3%A2-and-the-american-osteopathic-association-intern-resident-registration-program
#5
Stanley M Kozakowski, Alexandra Travis, Julie P Marcinek, Ashley Bentley, Gerald T Fetter
The purpose of medicine as a profession is to meet the health needs of people and communities. Despite empirical evidence worldwide that an appropriate foundation of primary care in a health care system leads to improved health outcomes, improved experience of health care, a reduction in health disparities, and lower overall cost of care, publicly available data from National Resident Matching Program® (NRMP) and the American Osteopathic Association (AOA) Intern/Resident Registration Program show that PGY-1 family medicine and primary care positions offered in the NRMP Match continue to grow, but are losing ground in comparison to the growth of non-primary care specialties...
October 2017: Family Medicine
https://www.readbyqxmd.com/read/29033909/benzene-and-naphthalene-degrading-bacterial-communities-in-an-oil-sands-tailings-pond
#6
Fauziah F Rochman, Andriy Sheremet, Ivica Tamas, Alireza Saidi-Mehrabad, Joong-Jae Kim, Xiaoli Dong, Christoph W Sensen, Lisa M Gieg, Peter F Dunfield
Oil sands process-affected water (OSPW), produced by surface-mining of oil sands in Canada, is alkaline and contains high concentrations of salts, metals, naphthenic acids, and polycyclic aromatic compounds (PAHs). Residual hydrocarbon biodegradation occurs naturally, but little is known about the hydrocarbon-degrading microbial communities present in OSPW. In this study, aerobic oxidation of benzene and naphthalene in the surface layer of an oil sands tailings pond were measured. The potential oxidation rates were 4...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29025820/well-being-of-family-medicine-graduates
#7
Olga Szafran, Wayne Woloschuk, Jacqueline M I Torti, Douglas Myhre
OBJECTIVE: To determine family medicine graduates' professional and personal well-being, general health status, stress levels, coping strategies, and the degree to which they felt supported or isolated in professional life; and to compare findings by sex, practice location, and location of medical school (Canadian medical graduates [CMGs] vs international medical graduates [IMGs]). DESIGN: Retrospective, cross-sectional survey. SETTING: University of Alberta in Edmonton and the University of Calgary in Alberta...
October 2017: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/29025807/examination-outcomes-and-work-locations-of-international-medical-graduate-family-medicine-residents-in-canada
#8
Maria Mathews, Rima Kandar, Steve Slade, Yanqing Yi, Sue Beardall, Ivy Bourgeault
OBJECTIVE: To describe the postgraduate medical education (PGME) examination outcomes and work locations of international medical graduates (IMGs); and to identify differences between Canadians studying abroad (CSAs) and non-CSAs. DESIGN: Cohort study using data from the National IMG Database and Scott's Medical Database. SETTING: Canada. PARTICIPANTS: All IMGs who had first entered a family medicine residency program between 2005 and 2009, with the exclusion of US graduates, visa trainees, and fellowship trainees...
October 2017: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/28983854/a-pilot-study-examining-factors-influencing-readiness-to-progress-to-indirect-supervision-among-first-year-residents-in-a-general-psychiatry-training-program
#9
Bryan Touchet, Ashley Walker, Sarah Flanders, Heather McIntosh
OBJECTIVE: In the first year of training, psychiatry residents progress from direct supervision to indirect supervision but factors predicting time to transition between these levels of supervision are unknown. This study aimed to examine times for transition to indirect levels of supervision and to identify resident factors associated with slower progression. METHODS: The authors compiled data from training files from years 2011-2015, including licensing exam scores, age, gender, medical school, month of first inpatient psychiatry rotation, and transition times between levels of supervision...
October 5, 2017: Academic Psychiatry
https://www.readbyqxmd.com/read/28979916/addressing-the-physicians-shortage-in-developing-countries-by-accelerating-and-reforming-the-medical-education-is-it-possible
#10
Mustafa Al-Shamsi
INTRODUCTION: Doctors' shortage has remained a concern worldwide. The developed countries started aids to recruit international medical graduates (IMG) to cope with the defects that the health care system suffers from; however, this solution may not work in developing countries that have a limited resource and poor budget to spend on the health care system. This study aims to present an alternative way to approach the physicians' shortage by accelerating undergraduate medical education and reform some post-graduate courses in order to cope with this problem...
October 2017: Journal of Advances in Medical Education & Professionalism
https://www.readbyqxmd.com/read/28973033/integrative-genetic-analysis-suggests-that-skin-color-modifies-the-genetic-architecture-of-melanoma
#11
Imge Hulur, Andrew D Skol, Eric R Gamazon, Nancy J Cox, Kenan Onel
Melanoma is the deadliest form of skin cancer and presents a significant health care burden in many countries. In addition to ultraviolet radiation in sunlight, the main causal factor for melanoma, genetic factors also play an important role in melanoma susceptibility. Although genome-wide association studies have identified many single nucleotide polymorphisms associated with melanoma, little is known about the proportion of disease risk attributable to these loci and their distribution throughout the genome...
2017: PloS One
https://www.readbyqxmd.com/read/28956675/ingenol-mebutate-for-the-treatment-of-actinic-keratosis-effectiveness-and-safety-in-246-patients-treated-in-real-life-clinical-practice
#12
Rosa Ortega Del Olmo, Rafael Salido-Vallejo
INTRODUCTION: The aim of the study was to evaluate the results on effectiveness and safety of topical treatment for Actinic Keratosis (AK) with Ingenol Mebutate Gel (IMG) in real-life conditions and to perform an analysis of the factors that may influence the treatment outcomes. MATERIALS AND METHODS: Retrospective study of patients with non-hyperkeratotic AK lesions prescribed with IMG in Spain according to clinical practice. Dermatologists reported the characteristics of patients and AK at baseline, and the findings observed up to 60 days after treatment...
September 28, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28948352/nitrogen-form-and-mycorrhizal-inoculation-amount-and-timing-affect-flavonol-biosynthesis-in-onion-allium-cepa-l
#13
Mohanna Mollavali, Henrike Perner, Sascha Rohn, Peer Riehle, Franziska S Hanschen, Dietmar Schwarz
Mycorrhizal symbiosis is known to be the most prevalent form of fungal symbiosis with plants. Although some studies focus on the importance of mycorrhizal symbiosis for enhanced flavonoids in the host plants, a comprehensive understanding of the relationship still is lacking. Therefore, we studied the effects of mycorrhizal inoculation of onions (Allium cepa L.) regarding flavonol concentration and the genes involved in flavonol biosynthesis when different forms of nitrogen were supplied. We hypothesized that mycorrhizal inoculation can act as a biotic stress and might lead to an increase in flavonols and expression of related genes...
September 26, 2017: Mycorrhiza
https://www.readbyqxmd.com/read/28928366/fibromyalgia-and-microglial-tnf-%C3%AE-translational-research-using-human-blood-induced-microglia-like-cells
#14
Masahiro Ohgidani, Takahiro A Kato, Masako Hosoi, Makoto Tsuda, Kohei Hayakawa, Chie Hayaki, Rie Iwaki, Noriaki Sagata, Ryota Hashimoto, Kazuhide Inoue, Nobuyuki Sudo, Shigenobu Kanba
Fibromyalgia is a refractory disease characterized by chronic intractable pain and psychological suffering, the cause of which has not yet been elucidated due to its complex pathology. Activation of immune cells in the brain called microglia has attracted attention as a potential underlying pathological mechanism in chronic pain. Until recently, however, technological and ethical considerations have limited the ability to conduct research using human microglia. To overcome this limitation, we have recently developed a technique to create human-induced microglia-like (iMG) cells from human peripheral blood monocytes...
September 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28916321/analysis-of-resistance-genes-in-pan-resistant-myroides-odoratimimus-clinical-strain-pr63039-using-whole-genome-sequencing
#15
De-Song Ming, Qing-Qing Chen, Xiao-Tin Chen
To clarify the antibiotic resistance mechanisms of Myroides odoratimimus, pan-resistant M. odoratimimus strain PR63039 was isolated and its genome sequenced and analyzed. Antimicrobial susceptibility testing was conducted using the Kirby-Bauer disk diffusion method, and the Phoenix-100 Automated Microbiology System with a NMIC/ID-4 panel including aminoglycosides, β-lactams, polypeptides, quinolones, sulfonamides, chloramphenicols, and tetracyclines. Single-molecule real-time whole genome sequencing was conducted using the PacBio RSII system, and genome annotation was performed using RAST and IMG ER...
September 12, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28911863/the-crystal-structure-of-the-pyrococcus-abyssi-mono-functional-methyltransferase-patrm5b
#16
Jialiang Wu, Qian Jia, Saibin Wu, Hui Zeng, Yujie Sun, Caiyan Wang, Ruiguang Ge, Wei Xie
The wyosine hypermodification found exclusively at G37 of tRNA(Phe) in eukaryotes and archaea is a very complicated process involving multiple steps and enzymes, and the derivatives are essential for the maintenance of the reading frame during translation. In the archaea Pyrococcus abyssi, two key enzymes from the Trm5 family, named PaTrm5a and PaTrm5b respectively, start the process by forming N1-methylated guanosine (m(1)G37). In addition, PaTrm5a catalyzes the further methylation of C7 on 4-demethylwyosine (imG-14) to produce isowyosine (imG2) at the same position...
November 4, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28905708/williamwhitmania-taraxaci-gen-nov-sp-nov-a-proteolytic-anaerobe-with-a-novel-type-of-cytology-from-lake-untersee-in-antarctica-description-of-williamwhitmaniaceae-fam-nov-and-emendation-of-the-order-bacteroidales-krieg-2012
#17
Elena V Pikuta, Zhe Lyu, Richard B Hoover, Yuchen Liu, Nisha B Patel, Hans J Busse, Paul A Lawson
The proteolytic bacterium strain A7P-90m(T) was isolated from Lake Untersee, Antarctica. The anoxic water was collected from a perennially sealed (~100 millennia) glacial ice lake. Gram-stain-negative cells were 0.18-0.3×8.0-25.0 µm in size, straight, slender rods with unusual gliding motility by external, not previously reported, organelles named here as antiae. At the end of stationary phase of growth, spheroplasts were terminally formed and the cells resembled dandelions. After death, cells were helical...
October 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28900063/-translational-research-on-neuropsychiatric-disorders-focusing-on-microglia-hypothesis
#18
Takahiro A Kato, Masahiro Ohgidani, Shigenobu Kanba
Microglia-immune cells in the brain-have recently been highlighted to understand the pathophysiology of psychiatric disorders such as schizophrenia, depression, and autism. In this review paper, we introduce the microglia hypothesis for psychiatric disorders. In addition, we introduce our novel translational research approach to psychiatric disorders using microglia-like (iMG) cells directly induced from human blood, these iMG cells can be produced from peripheral monocytes within two weeks using two cytokines: granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-34 (IL-34)...
September 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/28869159/a-comparison-of-objective-assessment-data-for-the-united-states-and-international-medical-graduates-in-a-general-surgery-residency
#19
Francisco Cardenas Lara, Nimesh D Naik, T K Pandian, Becca L Gas, Suzanne Strubel, Rachel Cadeliña, Stephanie F Heller, David R Farley
OBJECTIVE: To compare objective assessment scores between international medical graduates (IMGs) and United States Medical Graduates. Scores of residents who completed a preliminary year, who later matched into a categorical position, were compared to those who matched directly into a categorical position at the Mayo Clinic, Rochester. DESIGN: Postgraduate year (PGY) 1 to 5 residents participate in a biannual multistation, OSCE-style assessment event as part of our surgical training program...
August 28, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28841816/medical-migration-a-qualitative-exploration-of-the-atypical-path-of-japanese-international-medical-graduates
#20
Brian S Heist, Haruka Matsubara Torok
BACKGROUND: International Medical Graduates (IMGs) are commonly understood to move from low to high resource countries with motivations including improved financial situations and cultures of emigration. A presumable exception to the above themes would be the Japanese IMG population. The aim of this study was to develop an understanding of the Japanese IMG experience. METHODS: Using a grounded theory approach, we interviewed 19 Japanese IMGs working in the US and 16 Japanese IMGs working in Japan who had completed US clinical training...
August 25, 2017: Medical Teacher
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