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https://www.readbyqxmd.com/read/28934545/antimicrobial-3d-porous-scaffolds-prepared-by-additive-manufacturing-and-breath-figures
#1
Nelson Vargas Alfredo, Ane Dorronsoro, Aitziber L Cortajarena, Juan Rodriguez-Hernandez
We describe herein a novel strategy for the fabrication of efficient 3D printed antibacterial scaffolds. For this purpose, both the surface topography as well as the chemical composition of 3D scaffolds fabricated by additive manufacturing were modified. The scaffolds were fabricated by fused deposition modeling (FDM) using high impact polystyrene (HIPS) filaments. The surface of the objects was then topographically modified providing materials with porous surfaces by means of the Breath Figures approach. The strategy involves the immersion of the scaffold in a polymer solution during a precise period of time...
September 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28931661/unemployment-in-chronic-airflow-obstruction-around-the-world-results-from-the-bold-study
#2
Rune Grønseth, Marta Erdal, Wan C Tan, Daniel O Obaseki, Andre F S Amaral, Thorarinn Gislason, Sanjay K Juvekar, Parvaiz A Koul, Michael Studnicka, Sundeep Salvi, Peter Burney, A Sonia Buist, William M Vollmer, Ane Johannessen
We aimed to examine associations between chronic airflow obstruction (CAO) and unemployment across the world.Cross-sectional data from 26 sites in the Burden of Obstructive Lung Disease (BOLD) study were used to analyse effects of CAO on unemployment. Odds ratios for unemployment in subjects aged 40-65 years were estimated using a multilevel mixed-effects generalised linear model with study site as random effect. Site-by-site heterogeneity was assessed using individual participant data meta-analyses.Out of 18 710 participants, 11...
September 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28930268/antioxidant-activity-of-essential-oil-extracted-by-sc-co%C3%A2-from-seeds-of-trachyspermum-ammi
#3
Aarti Singh, Anees Ahmad
Bcakground: Extracts obtained from natural sources such as plants are of immense importance for humans. Methods: Therefore this study was conducted to obtain essential oil from the seeds of T. ammi by conventional and non-conventional methods. Hydrodistillation (HD), Solvent Extraction (SE), Ultrasonication (US), and Supercritical Carbon-dioxide (SC-CO₂) extraction techniques were used to extract essential oil from the powdered seeds of T. ammi. A quality control method for each extracted oil was developed using HPTLC, FTIR, and GC-MS...
July 11, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28928137/recovery-of-cyp3a-phenotype-following-kidney-transplantation
#4
Kristine Hole, Elisabet Storset, Ane Olastuen, Tore Haslemo, Grete Birkeland Kro, Karsten Midtvedt, Anders Asberg, Espen Molden
End-stage renal disease (ESRD) impairs drug metabolism via cytochrome P450 (CYP) 3A. However, it is unclear whether CYP3A activity recovers following kidney transplantation. Therefore, the aim of this study was to evaluate the change in CYP3A activity measured as 4β-hydroxycholesterol (4βOHC) concentration after kidney transplantation. In total, data from 58 renal transplant recipients with 550 prospective 4βOHC measurements were included in the study. One sample per patient was collected before transplantation, and 2-12 samples per patient were collected 1-82 days after transplantation...
September 19, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28925580/nutrition-hygiene-and-stimulation-education-to-improve-growth-cognitive-language-and-motor-development-among-infants-in-uganda-a-cluster-randomized-trial
#5
Grace K M Muhoozi, Prudence Atukunda, Lien M Diep, Robert Mwadime, Archileo N Kaaya, Anne B Skaare, Tiril Willumsen, Ane C Westerberg, Per O Iversen
Stunting is associated with impaired cognitive and motor function. The effect of an education intervention including nutrition, stimulation, sanitation, and hygiene on child growth and cognitive/language/motor development, delivered to impoverished mothers in Uganda, was assessed. In a community-based, open cluster-randomized trial, 511 mother/children dyads aged 6-8 months were enrolled to an intervention (n = 263) or control (n = 248) group. The primary outcome was change in length-for-age z-score at age 20-24 months...
September 19, 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/28925186/does-the-editorial-committee-still-have-a-role-to-play
#6
Ola Dale, Erik Magnus Berntsen, Mette Brekke, Anne Høye, Ole-Erik Iversen, Ane Brandtzæg Næss, Torben Wisborg
No abstract text is available yet for this article.
September 19, 2017: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
https://www.readbyqxmd.com/read/28918752/correlation-of-csf-flow-using-phase-contrast-mri-with-ventriculomegaly-and-csf-opening-pressure-in-mucopolysaccharidoses
#7
Amauri Dalla Corte, Carolina F M de Souza, Maurício Anés, Fabio K Maeda, Armelle Lokossou, Leonardo M Vedolin, Maria Gabriela Longo, Monica M Ferreira, Solanger G P Perrone, Olivier Balédent, Roberto Giugliani
BACKGROUND: Very little is known about the incidence and prevalence of hydrocephalus in patients with mucopolysaccharidoses (MPS). The biggest challenge is to distinguish communicating hydrocephalus from ventricular dilatation secondary to brain atrophy, because both conditions share common clinical and neuroradiological features. The main purpose of this study is to assess the relationship between ventriculomegaly, brain and cerebrospinal fluid (CSF) volumes, aqueductal and cervical CSF flows, and CSF opening pressure in MPS patients, and to provide potential biomarkers for abnormal CSF circulation...
September 18, 2017: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/28916181/replicability-of-time-varying-connectivity-patterns-in-large-resting-state-fmri-samples
#8
Anees Abrol, Eswar Damaraju, Robyn L Miller, Julia M Stephen, Eric D Claus, Andrew R Mayer, Vince D Calhoun
The past few years have seen an emergence of approaches that leverage temporal changes in whole-brain patterns of functional connectivity (the chronnectome). In this chronnectome study, we investigate the replicability of the human brain's inter-regional coupling dynamics during rest by evaluating two different dynamic functional network connectivity (dFNC) analysis frameworks using 7 500 functional magnetic resonance imaging (fMRI) datasets. To quantify the extent to which the emergent functional connectivity (FC) patterns are reproducible, we characterize the temporal dynamics by deriving several summary measures across multiple large, independent age-matched samples...
September 12, 2017: NeuroImage
https://www.readbyqxmd.com/read/28915942/development-of-a-validated-lc-ms-ms-method-for-the-quantification-of-19-endogenous-asthma-copd-potential-urinary-biomarkers
#9
Mona M Khamis, Darryl J Adamko, Anas El-Aneed
Obstructive airways inflammatory diseases sometimes show overlapping symptoms that hinder their early and correct diagnosis. Current clinical tests are tedious and are of inadequate specificity in special population such as the elderly and children. Therefore, we are developing tandem mass spectrometric (MS/MS) methods for targeted analysis of urine biomarkers. Recently, proton-nuclear magnetic resonance ((1)H-NMR) analysis proposed 50 urinary metabolites as potential diagnostic biomarkers among asthma and chronic obstructive pulmonary disease (COPD) patients...
October 9, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28901586/long-term-effects-of-cardiac-resynchronization-therapy-on-electrical-remodeling-in-heart-failure-a-prospective-study
#10
Bharatraj Banavalikar, Anees Thajudeen, Narayanan Namboodiri, Krishna Kumar Mohanan Nair, Abhilash Srivilasam Pushpangadhan, Ajit Kumar Valaparambil
INTRODUCTION: Effects of cardiac resynchronization therapy (CRT) on arrhythmogenicity and sudden death have not been fully ascertained. CRT has been shown to increase transmural dispersion of repolarization (TDR) immediately on implantation, that may favorably remodel on long-term follow-up. However, such a hypothesis has not been prospectively evaluated. METHODS AND RESULTS: We included 35 consecutive patients who underwent CRT implantation between September 2013 & August 2014 (mean age 56...
September 13, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28899497/molecular-targets-and-anticancer-potential-of-sanguinarine-a-benzophenanthridine-alkaloid
#11
REVIEW
Sehamuddin Galadari, Anees Rahman, Siraj Pallichankandy, Faisal Thayyullathil
BACKGROUND: Cancer is an enormous global health burden, and should be effectively addressed with better therapeutic strategies. Currently, over 60% of the clinically approved anticancer agents are either directly isolated from natural sources or are modified from natural lead molecules. Sanguinarine (SNG), a quaternary benzophenanthridine alkaloid has gained increasing attention in recent years as a potential anticancer agent. PURPOSE: There is a large untapped source of phytochemical-based anticancer agents remaining to be explored...
October 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28898717/targeting-dendritic-cells-through-gold-nanoparticles-a-review-on-the-cellular-uptake-and-subsequent-immunological-properties
#12
REVIEW
Suhana Ahmad, Anes Ateqah Zamry, Hern-Tze Tina Tan, Kah Keng Wong, JitKang Lim, Rohimah Mohamud
Gold nanoparticles (NPs) have been proposed as a highly potential tool in immunotherapies due to its advantageous properties including customizable size and shapes, surface functionality and biocompatibility. Dendritic cells (DCs), the sentinels of immune response, have been of interest to be manipulated by using gold NPs for targeted delivery of immunotherapeutic agent. Researches done especially in human DCs showed a variation of gold NPs effects on cellular uptake and internalization, DC maturation and subsequent T cells priming as well as cytotoxicity...
September 9, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28888871/interplay-of-mitochondria-apoptosis-regulatory-factors-and-micrornas-in-valvular-heart-disease
#13
Muhammad Ishtiaq Jan, Riaz Anwar Khan, Tahir Ali, Muhammad Bilal, Long Bo, Abdul Sajid, Abdul Malik, Naseeb Urehman, Nayyar Waseem, Javed Nawab, Murad Ali, Abdul Majeed, Hamid Ahmad, Sohail Aslam, Sadia Hamera, Aneesa Sultan, Mariam Anees, Qamar Javed, Iram Murtaza
Valvular heart disease (VHD) is an active process involving a wide range of pathological changes. The major complications of VHD are stenosis and regurgitation, which are macroscopic phenomena, induced in part through cellular changes. Altered expression of mitochondria associated genes causes membrane potential depolarization, leading to the increased levels of apoptosis observed in cardiac dysfunction. Objective of this study is to find molecular medicine candidates that can control expression of the key mitochondria apoptosis regulatory genes...
September 6, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28888838/space-for-human-connection-in-antenatal-education-uncovering-women-s-hopes-using-participatory-action-research
#14
Vivienne Brady, Joan Lalor
OBJECTIVE: the aim of this research was to initiate active consultation with women and antenatal educators in the development and delivery of antenatal education that was mutually relevant. DESIGN: a Participatory Action Research approach influenced by feminist concerns was used to guide the research. Data were analysed by the researcher and participants using a Voice Centred Relational Method of Analysis. SETTING: an Antenatal Education service in a consultant-led tertiary referral unit in Ireland...
August 30, 2017: Midwifery
https://www.readbyqxmd.com/read/28885450/automated-evaluation-of-choroidal-thickness-and-minimum-rim-width-thickness-in-nonarteritic-anterior-ischemic-optic-neuropathy
#15
Ane Pérez-Sarriegui, Francisco J Muñoz-Negrete, Susana Noval, Victoria De Juan, Gema Rebolleda
BACKGROUND: The aim of this study was to evaluate and compare peripapillary choroidal thickness (pCT) and macular choroidal thickness (CT), Bruch membrane opening-minimum rim width (BMO-MRW), retinal nerve fiber layer (RNFL) thickness, and optic disc area among nonarteritic anterior ischemic optic neuropathy (NAION) eyes, the contralateral unaffected eyes, and healthy control eyes. METHODS: Twenty-six patients diagnosed with NAION (29 affected and 21 unaffected eyes) and 29 healthy matched control individuals (29 eyes) were analyzed by swept-source optical coherence tomography...
September 6, 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/28883816/modulation-of-zinc-homeostasis-in-acanthamoeba-castellanii-as-a-possible-antifungal-strategy-against-cryptococcus-gattii
#16
Nicole S Ribeiro, Francine M Dos Santos, Ane W A Garcia, Patrícia A G Ferrareze, Laura F Fabres, Augusto Schrank, Livia Kmetzsch, Marilise B Rott, Marilene H Vainstein, Charley C Staats
Cryptococcus gattii is a basidiomycetous yeast that can be found in the environment and is one of the agents of cryptococcosis, a life-threatening disease. During its life cycle, cryptococcal cells take hold inside environmental predators such as amoebae. Despite their evolutionary distance, macrophages and amoebae share conserved similar steps of phagocytosis and microbial killing. To evaluate whether amoebae also share other antifungal strategies developed by macrophages, we investigated nutritional immunity against cryptococcal cells...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28870350/first-report-on-molecular-characterization-of-leishmania-species-from-cutaneous-leishmaniasis-patients-in-southern-khyber-pakhtunkhwa-province-of-pakistan
#17
Mubbashir Hussain, Shahzad Munir, Sultan Ayaz, Bahar Ullah Khattak, Taj Ali Khan, Niaz Muhammad, Muhammad Anees, Hazir Rahman, Muhammad Qasim, Muhammad Ameen Jamal, Irfan Ahmed, Kashif Rahim, Humaira Mazhar, Noha Watanay, Mohamed Kasbari
OBJECTIVE: To report presence of Leishmania major in Khyber Pakhtunkhwa of Pakistan, where cutaneous leishmaniasis (CL) is endemic and was thought to be caused by Leishmania tropica only. METHODS: Biopsy samples from 432 CL suspected patients were collected from 3 southern districts of Khyber Pakhtunkhwa during years 2011-2016. Microscopy on Giemsa stained slides were done followed by amplification of the ribosomal internal transcribed spacer 1 gene. RESULTS: Leishmania amastigotes were detected by microscopy in 308 of 432 samples (71...
July 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28865875/photochemical-internalization-pci-of-bleomycin-is-equally-effective-in-two-dissimilar-leiomyosarcoma-xenografts-in-athymic-mice
#18
Simen Sellevold, Qian Peng, Ane Sofie Viset Fremstedal, Kristian Berg
BACKGROUND: Photochemical internalization (PCI) is a novel technique for delivery of active macromolecules into cancerous cells, via light activation of a specific photosensitizer and a low dose systemic drug. Numerous pre-clinical studies and one clinical trial have confirmed the treatment potential in carcinomas. Soft tissue sarcomas are rare and generally resistant to radio- and chemotherapy. Due to treatment resistance and surgical morbidity in sarcoma care, we seek to increase knowledge on PCI effects in sarcomas by studying two different, but closely related leiomyosarcomas...
August 30, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28865625/proximate-composition-phenolic-content-and-in-vitro-antioxidant-activity-of-aqueous-extracts-of-the-seaweeds-ascophyllum-nodosum-bifurcaria-bifurcata-and-fucus-vesiculosus-effect-of-addition-of-the-extracts-on-the-oxidative-stability-of-canola-oil-under-accelerated
#19
Rubén Agregán, Paulo E Munekata, Ruben Domínguez, Javier Carballo, Daniel Franco, José M Lorenzo
Extracts from three macroalgae species (Ascophyllum nodosum (ANE), Bifurcaria bifurcata (BBE) and Fucus vesiculosus (FVE)) were tested for proximate composition (total solid, protein and total carbohydrate contents), total phenols content (TPC), and for their antioxidant activities in vitro in comparison to that of BHT compound by using four different assays (ABTS radical cation decolouration, DPPH free radical scavenging activity, ferric reducing antioxidant power (FRAP) and oxygen radical absorbance capacity (ORAC))...
September 2017: Food Research International
https://www.readbyqxmd.com/read/28865624/phenolic-compounds-from-three-brown-seaweed-species-using-lc-dad-esi-ms-ms
#20
Rubén Agregán, Paulo E S Munekata, Daniel Franco, Ruben Dominguez, Javier Carballo, José M Lorenzo
The phenolic compounds of extracts from Ascophyllum nodosum (ANE), Bifurcaria bifurcata (BBE) and Fucus vesiculosus (FVE) from Galicia (NW Spain) were analyzed by liquid chromatography-diode array detection coupled to negative electrospray ionization-tandem mass spectrometry (LC-DAD-ESI-MS/MS) with the interest to evaluate their potential application as functional ingredients. Phlorotannins were tentatively identified as the main phenolic compounds in the three extracts, followed by phenolic acids, and flavonoids...
September 2017: Food Research International
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