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Brigid K Killelea, Anees B Chagpar, Nina R Horowitz, Donald R Lannin
BACKGROUND: Although identification of human epidermal growth factor receptor 2 (Her2) positive breast cancer represents one of the greatest advances over the past 3 decades, it has not been studied extensively on a national level. METHODS: The National Cancer Database is a joint project of the American Cancer Society and the American College of Surgeons and contains data on about 70% of the cancer cases in the United States. Data on Her2 have been collected since 2010 and was used for this study...
July 21, 2016: American Journal of Surgery
Zuriñe Antón, Ane Landajuela, Javier H Hervás, L Ruth Montes, Sonia Hernández-Tiedra, Guillermo Velasco, Felix M Goñi, Alicia Alonso
The phospholipid cardiolipin (CL) has been proposed to play a role in selective mitochondrial autophagy, or mitophagy. CL externalization to the outer mitochondrial membrane would act as a signal for the human Atg8 ortholog subfamily, MAP1LC3 (LC3). The latter would mediate both mitochondrial recognition and autophagosome formation, ultimately leading to removal of damaged mitochondria. We have applied quantitative biophysical techniques to the study of CL interaction with various Atg8 human orthologs, namely LC3B, GABARAPL2 and GABARAP...
October 20, 2016: Autophagy
Lívia C Lionço, Angelo A de Mattos, Alex F Horbe, Ane M Costabeber, Ângelo Z de Mattos, Dorvaldo P Tarasconi
OBJECTIVE: The main aim of this study was to evaluate the real-life survival rates of patients with intermediate-stage hepatocellular carcinoma treated with transarterial chemoembolization. METHODS: A retrospective cohort study involving 95 patients was conducted and the studied variables were analysed according to survival. Treatment response was determined using the Modified Response Evaluation Criteria in Solid Tumors assessment. The Kaplan-Meier method and Cox regression were used to analyse survival...
October 18, 2016: European Journal of Gastroenterology & Hepatology
Joseph P Kitzmiller, Eduard B Mikulik, Anees M Dauki, Chandrama Murkherjee, Jasmine A Luzum
Statins are a cornerstone of the pharmacologic treatment and prevention of atherosclerotic cardiovascular disease. Atherosclerotic disease is a predominant cause of mortality and morbidity worldwide. Statins are among the most commonly prescribed classes of medications, and their prescribing indications and target patient populations have been significantly expanded in the official guidelines recently published by the American and European expert panels. Adverse effects of statin pharmacotherapy, however, result in significant cost and morbidity and can lead to nonadherence and discontinuation of therapy...
2016: Pharmacogenomics and Personalized Medicine
Anshu K Jain, Mary L Fennell, Anees B Chagpar, Hannah K Connolly, Ingrid M Nembhard
Effective communication is a requirement in the teamwork necessary for improved coordination to deliver patient-centered, value-based cancer care. Communication is particularly important when care providers are geographically distributed or work across organizations. We review organizational and teams research on communication to highlight psychological safety as a key determinant of high-quality communication within teams. We first present the concept of psychological safety, findings about its communication effects for teamwork, and factors that affect it...
October 18, 2016: Journal of Oncology Practice
Malene Rask Andersen, Muhammad Farooq, Karen Koefoed, Klaus W Kjaer, Ane Simony, Sren Tvorup Christensen, Lars Allan Larsen
STUDY DESIGN: Mutation analysis of a candidate disease gene in a cohort of patients with moderate to severe Adolescent idiopathic scoliosis (AIS). OBJECTIVE: To investigate if damaging mutations in the planar cell polarity gene VANGL1 could be identified in AIS patients. SUMMARY OF BACKGROUND DATA: AIS is a spinal deformity which occurs in 1-3% of the population. The cause of AIS is often unknown, but genetic factors are important in the etiology...
October 17, 2016: Spine
Anees A Ansari, Abdul K Parchur, Brijesh Kumar, S B Rai
The design of nanostructured materials with highly stable water-dispersion and luminescence efficiency is an important concern in nanotechnology and nanomedicine. In this paper, we described the synthesis and distinct surface modification on the morphological structure and optical (optical absorption, band gap energy, excitation, emission, decay time, etc.) properties of highly crystalline water-dispersible CaF2:Ce/Tb nanocrystals (core-nanocrystals). The epitaxial growth of inert CaF2 and silica shell, respectively, on their surface forming as CaF2:Ce/Tb@CaF2 (core/shell) and CaF2:Ce/Tb@CaF2@SiO2 (core/shell/SiO2) nanoarchitecture...
December 2016: Journal of Materials Science. Materials in Medicine
Mukund A Prabhu, B V Srinivas Prasad, Anees Thajudeen, Narayanan Namboodiri
INTRODUCTION: Bundle branch reentry as a mechanism of ventricular tachycardia (VT) in endomyocardial fibrosis (EMF) is not described. CASE REPORT: A 52-year-old woman with left ventricular (LV) EMF had VT needing cardioversion. She had mitral regurgitation and left bundle branch block, but no LV dilation or heart failure. During electrophysiological study, clinical VT could be easily induced, and it was confirmed to be bundle branch reentrant VT (BBRVT). She was treated with ablation of the right bundle branch...
September 2016: Indian Heart Journal
Harald Marx, Catherine E Minogue, Dhileepkumar Jayaraman, Alicia L Richards, Nicholas W Kwiecien, Alireza F Sihapirani, Shanmugam Rajasekar, Junko Maeda, Kevin Garcia, Angel R Del Valle-Echevarria, Jeremy D Volkening, Michael S Westphall, Sushmita Roy, Michael R Sussman, Jean-Michel Ané, Joshua J Coon
Legumes are essential components of agricultural systems because they enrich the soil in nitrogen and require little environmentally deleterious fertilizers. A complex symbiotic association between legumes and nitrogen-fixing soil bacteria called rhizobia culminates in the development of root nodules, where rhizobia fix atmospheric nitrogen and transfer it to their plant host. Here we describe a quantitative proteomic atlas of the model legume Medicago truncatula and its rhizobial symbiont Sinorhizobium meliloti, which includes more than 23,000 proteins, 20,000 phosphorylation sites, and 700 lysine acetylation sites...
October 17, 2016: Nature Biotechnology
Andrew G Palmer, Arijit Mukherjee, Danielle M Stacy, Stephen Lazar, Jean-Michel Ané, Helen E Blackwell
Density-dependent phenotypic switching in bacteria, the phenomenon of quorum sensing (QS), is instrumental in many pathogenic and mutualistic behaviors. In many Gram-negative bacteria, QS is regulated by N-acylated-l-homoserine lactones (AHLs). Synthetic analogues of these AHLs hold significant promise for regulating QS at the host-symbiont interface. Regulation depends on refined temporal and spatial models of quorums under native conditions. Critical to this is an understanding of how the presence of these signals may affect a prospective host...
October 14, 2016: Chembiochem: a European Journal of Chemical Biology
Nicolás Herranz, Natàlia Dave, Alba Millanes-Romero, Laura Pascual, Lluis Morey, Víctor M Díaz, Víctor Lórenz-Fonfría, Ricardo Gutierrez-Gallego, Celia Jerónimo, Ane Iturbide, Luciano Di Croce, Antonio García de Herreros, Sandra Peiró
Methylation of histone H3 lysine 4 is linked to active transcription and can be removed by LSD1 or the JmjC domain-containing proteins by amino-oxidation or hydroxylation, respectively. Here we describe that its deamination can be catalyzed by lysyl oxidase-like 2 protein (LOXL2), presenting an unconventional chemical mechanism for H3K4 modification. Infrared spectroscopy and mass spectrometry analyses demonstrated that recombinant LOXL2 specifically deaminates trimethylated H3K4. Moreover, by regulating H3K4me3 deamination, LOXL2 activity is linked with the transcriptional control of the CDH1 gene...
October 13, 2016: FEBS Journal
Jonathan Aning
No abstract text is available yet for this article.
October 13, 2016: British Journal of Nursing: BJN
Susana Garcia-Gutierrez, José Maria Quintana, Ane Antón-Ladislao, Maria Soledad Gallardo, Esther Pulido, Irene Rilo, Elena Zubillaga, Miren Morillas, José Juan Onaindia, Nekane Murga, Ricardo Palenzuela, José González Ruiz
Our aims were to create and validate a clinical decision rule to assess severity in acute heart failure. We conducted a prospective cohort study of patients with symptoms of acute heart failure who attended the emergency departments (EDs) of three hospitals between April 2011 and April 2013. The following data were collected on arrival to or during the stay in the ED: baseline severity of symptoms; presence of decompensated comorbidities; number of hospital admissions/visits to EDs for acute heart failure during the previous 24 months; triggers of the exacerbation; clinical signs and symptoms; results of ancillary tests requested in the ED; treatments prescribed; and response to the initial treatment in the ED...
October 11, 2016: Internal and Emergency Medicine
Erin Gemperline, Caitlin Keller, Dhileepkumar Jayaraman, Junko Maeda, Michael R Sussman, Jean-Michel Ané, Lingjun Li
Plant science is an important, rapidly developing area of study. Within plant science, one area of study that has grown tremendously with recent technological advances, such as mass spectrometry, is the field of plant-omics; however, plant peptidomics is relatively underdeveloped in comparison with proteomics and metabolomics. Endogenous plant peptides can act as signaling molecules and have been shown to affect cell division, development, nodulation, reproduction, symbiotic associations, and defense reactions...
October 11, 2016: Journal of Proteome Research
Paloma Triana, Mariela Dore, Martha Muñoz Romo, Javier Jimenez Gomez, Alba Sánchez Galán, Francisco Hernandez, Ane M Andres Moreno, Jose Luis Encinas, Leopoldo Martinez, Manuel Lopez Santamaria
Aim Hepatocellular carcinoma (HCC), although being infrequent, is the second-most common primary hepatic malignancy in children, after hepatoblastoma (HB). The prognosis is very poor. We present our series of children with HCC referred to our transplant unit to be assessed as candidates for liver transplantation (LT). Methods A retrospective review of HCCs referred to our transplant unit in the past 20 years (1994-2015) was performed. Age at diagnosis, disease-free survival, location of recurrence, initial treatment, secondary treatment, and mortality were noted...
October 10, 2016: European Journal of Pediatric Surgery
Ane Andrade Santa Cecília Silva, Tássia do Vale Cardoso Lopes, Kely Raspante Teixeira, Jordane Amaral Mendes, Matheus Eduardo de Souza Borba, Maria Carliana Mota, Jim Waterhouse, Cibele Aparecida Crispim
Subjective responses to meals are altered by shortened sleep time and anxiety state, but this effect has been poorly studied in shift workers - who act as a typical model concerning sleep restriction and present high levels of anxiety. The objective of this study was to compare subjective perceptions of meals and the levels of anxiety in the same subjects after working night shifts and after taking a nocturnal sleep, and to investigate associations between the responses to meals and the levels of anxiety under these two conditions...
October 6, 2016: Appetite
Anees A Syed, Shibani Lahiri, Divya Mohan, Guru R Valicherla, Anand P Gupta, Mohammed Riyazuddin, Sudhir Kumar, Rakesh Maurya, Kashif Hanif, Jiaur R Gayen
ETHNOPHARMACOLOGICAL RELEVANCE: Ulmus wallichiana Planchon (Himalayan Elm), a traditional medicinal plant, used in fracture healingin folk tradition of Uttarakhand, Himalaya, India. It is also used as diuretic. U. rhynchophylla, native to China, known as Gou Teng in Chinese medicine, is used for hypertension (WHO). U. macrocarpa has antihypertensive and vasorelaxant activity. However, no detailed studies related to hypertension have been reported previously, so we have explored the antihypertensive activity of U...
October 5, 2016: Journal of Ethnopharmacology
Ingrid Toftaker, Javier Sanchez, Maria Stokstad, Ane Nødtvedt
Bovine respiratory syncytial virus (BRSV) and bovine coronavirus (BCoV) are considered widespread among cattle in Norway and worldwide. This cross-sectional study was conducted based on antibody-ELISA of bulk tank milk (BTM) from 1347 herds in two neighboring counties in western Norway. The study aims were to determine the seroprevalence at herd level, to evaluate risk factors for BRSV and BCoV seropositivity, and to assess how these factors were associated with the spatial distribution of positive herds. The overall prevalence of BRSV and BCoV positive herds in the region was 46...
October 1, 2016: Preventive Veterinary Medicine
Riham Gharib, Lizette Auezova, Catherine Charcosset, Hélène Greige-Gerges
A combined approach based on cyclodextrin/drug inclusion complex formation and loading into liposomes was applied to improve the effectiveness of liposome loading with essential oils. Hydroxypropyl-β-cyclodextrin/ANE (HP-β-CD/ANE) inclusion complexes were prepared and encapsulated into liposomes (ACL). ANE-double-loaded liposomes (ACL2) were obtained with the HP-β-CD/ANE complex in the aqueous phase and ANE in the organic phase. Liposomes were prepared from saturated (Phospholipon 90H) or unsaturated (Lipoid S100) phospholipids and characterized for size, polydispersity index, zeta potential, morphology, loading rate (LR) and photo- and storage stabilities...
March 1, 2017: Food Chemistry
Yun-Chi Wang, Yen-Peng Liang, Jhen-Yu Cai, Yun-Jui He, Yin-Hsuan Lee, Yi-Tsu Chan
Two hexanuclear metalloprisms possessing three dibenzo[24]crown-8 units were generated in quantitative yields by complexation of the predesigned tetratopic 2,2':6',2''-terpyridine ligand (T) with Cd(II) and Zn(II) ions, respectively. The prismatic hosts were subsequently self-assembled with the trifunctional guest molecule (TriG) containing dibenzylammonium ions to afford the corresponding metallo-supramolecular pseudo-suit[3]anes. It was serendipitously found that the host-guest inclusion rates could be modulated by the subtle dynamic difference in metal-ligand frameworks, finally leading to a selective encapsulation event in the presence of both metallo-suits...
October 18, 2016: Chemical Communications: Chem Comm
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