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https://www.readbyqxmd.com/read/28723254/possible-error-in-the-danish-version-of-the-who-quality-of-life-whoqol-bref-questionnaire
#1
Ane Søndergaard Thomsen, Per Bech
BACKGROUND: The WHOQOL-BREF is widely used to measure quality of life. AIMS: The goal of the present study was to use the questionnaire in a doctoral study. METHODS: We studied all the instructions provided by the WHO. RESULTS: In the Danish version of the WHOQOL-BREF there is a discrepancy between the negatively phrased question 9 and both the syntax file and the verbal instructions for coding the data provided by the WHO...
July 19, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/28718772/performance-evaluation-of-macaco-a-multilayer-compton-camera
#2
Enrique Muñoz, John Barrio, Ane Etxebeste, Pablo Garcia Ortega, Carlos Lacasta, Josep Francisco Oliver, Carles Solaz, Gabriela Llosa
Compton imaging devices have been proposed and studied for a wide range of applications. We have developed a Compton camera prototype which can be operated with two or three detector layers based on monolithic lanthanum bromide (LaBr3) crystals coupled to silicon photomultipliers (SiPMs), to be used for proton range verification in hadron therapy. In this work, we present the results obtained with our prototype in laboratory tests with radioactive sources and in simulation studies...
July 18, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28715600/ultrastructural-study-of-the-neural-microcircuits-in-the-sensory-epithelium-of-the-paratympanic-organ-of-the-chicken
#3
F Giannessi, L Ryskalin, R Ruffoli
The paratympanic organ (PTO) is a sensory organ located in the medial wall of the tympanic cavity of birds. The organ looks like a small tapering vesicle, and is equipped with a sensory epithelium formed by supporting cells (SCs) and Type II hair cells (Type II-HCs). The function of the PTO has not yet been precisely defined. The prevailing current hypothesis is that the PTO assesses the air pressure exerted on the external surface of the tympanic membrane. The PTO could may thus function as a barometer and, in flying birds, also as an altimeter...
July 1, 2017: Archives Italiennes de Biologie
https://www.readbyqxmd.com/read/28706837/intraosseous-infiltration-of-platelet-rich-plasma-for-severe-hip-osteoarthritis
#4
Nicolás Fiz, Juan Carlos Pérez, Jorge Guadilla, Ane Garate, Pello Sánchez, Sabino Padilla, Diego Delgado, Mikel Sánchez
This work describes a technique of platelet-rich plasma (PRP) infiltration for the treatment of severe hip osteoarthritis (OA). Although the results achieved with intra-articular infiltrations of PRP are promising, they may be insufficient in the long-term for severe hip OA. The technique consists of a combined intra-articular and intraosseous infiltration of PRP to reach all joint tissues, especially the subchondral bone, and hence facilitate a greater distribution of PRP. Diagnosis is based on clinical and radiographic findings, and patients with grade III OA according to the Tönnis scale, as well as patients who have not responded to conventional treatment, are considered candidates for this technique...
June 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28688525/heterogeneous-fdg-guided-dose-escalation-for-locally-advanced-nsclc-the-narlal2-trial-design-and-early-dosimetric-results-of-a-randomized-multi-centre-phase-iii-study
#5
Ditte Sloth Møller, Tine Bjørn Nielsen, Carsten Brink, Lone Hoffmann, Christina Maria Lutz, Mikkel Drøgemüller Lund, Olfred Hansen, Tine Schytte, Azza Ahmed Khalil, Marianne Marquard Knap, Christa Haugaard Nyhus, Wiviann Ottosson, Patrik Sibolt, Svetlana Borissova, Mirjana Josipovic, Gitte Persson, Ane Lindegaard Appelt
BACKGROUND AND PURPOSE: Local recurrence is frequent in locally advanced NSCLC and is primarily located in FDG-avid parts of tumour and lymph nodes. Aiming at improving local control without increasing toxicity, we designed a multi-centre phase-III trial delivering inhomogeneous dose-escalation driven by FDG-avid volumes, while respecting normal tissue constraints and requiring no increase in mean lung dose. Dose-escalation driven by FDG-avid volumes, delivering mean doses of 95Gy (tumour) and 74Gy (lymph nodes), was pursued and compared to standard 66Gy/33F plans...
July 5, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28685658/narrow-qrs-tachycardia-with-rr-alternans-and-qrs-alternans-what-is-the-mechanism
#6
Krishna Kumar Mohanan Nair, Narayanan Namboodiri, Sreevilasam Pushpangadhan Abhilash, Anees Thajudeen, Ajitkumar Valaparambil
No abstract text is available yet for this article.
July 7, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28680855/p21-activated-kinase-4-signaling-promotes-japanese-encephalitis-virus-mediated-inflammation-in-astrocytes
#7
Wen He, Zikai Zhao, Awais Anees, Yunchuan Li, Usama Ashraf, Zheng Chen, Yunfeng Song, Huanchun Chen, Shengbo Cao, Jing Ye
Japanese encephalitis virus (JEV) targets central nervous system, resulting in neuroinflammation with typical features of neuronal death along with hyper activation of glial cells. Exploring the mechanisms responsible for the JEV-caused inflammatory response remains a pivotal area of research. In the present study, we have explored the function of p21-activated kinase 4 (PAK4) in JEV-mediated inflammatory response in human astrocytes. The results showed that JEV infection enhances the phosphorylation of PAK4 in U251 cells and mouse brain...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28674552/exogenous-silicon-attenuates-cadmium-induced-oxidative-stress-in-brassica-napus-l-by-modulating-asa-gsh-pathway-and-glyoxalase-system
#8
Mirza Hasanuzzaman, Kamrun Nahar, Taufika Islam Anee, Masayuki Fujita
Cadmium (Cd) brings a devastating health hazard to human being as a serious consequence of agricultural and environmental contamination. We demonstrated the protective effect of silicon (Si) on cadmium (Cd)-stressed rapeseed (Brassica napus L. cv. BINA Sharisha 3) plants through regulation of antioxidant defense and glyoxalase systems. Twelve-day-old seedlings were exposed to Cd stress (0.5 and 1.0 mM CdCl2) separately and in combination with Si (SiO2, 1.0 mM) for 2 days. Cadmium toxicity was evident by an obvious oxidative stress through sharp increases in H2O2 content and lipid peroxidation (malondialdehyde, MDA content), and visible sign of superoxide and H2O2...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28674015/limits-of-brazil-s-forest-code-as-a-means-to-end-illegal-deforestation
#9
Andrea A Azevedo, Raoni Rajão, Marcelo A Costa, Marcelo C C Stabile, Marcia N Macedo, Tiago N P Dos Reis, Ane Alencar, Britaldo S Soares-Filho, Rayane Pacheco
The 2012 Brazilian Forest Code governs the fate of forests and savannas on Brazil's 394 Mha of privately owned lands. The government claims that a new national land registry (SICAR), introduced under the revised law, could end illegal deforestation by greatly reducing the cost of monitoring, enforcement, and compliance. This study evaluates that potential, using data from state-level land registries (CAR) in Pará and Mato Grosso that were precursors of SICAR. Using geospatial analyses and stakeholder interviews, we quantify the impact of CAR on deforestation and forest restoration, investigating how landowners adjust their behaviors over time...
July 3, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28673549/biochemical-and-genetic-characterization-of-an-unusual-mild-pex3-related-zellweger-spectrum-disorder
#10
Kathrine Bjørgo, Roar Fjær, Hanne Håberg Mørk, Sacha Ferdinandusse, Kim D Falkenberg, Hans R Waterham, Ane-Marte Øye, Alma Sikiric, Silja Svanstrøm Amundsen, Mari Ann Kulseth, Kaja Selmer
Patients with PEX3 mutations usually present with a severe form of Zellweger spectrum disorder with death in the first year of life. Whole exome sequencing in adult siblings with intellectual disability revealed a homozygous variant in PEX3 that abolishes the normal splice site. A cryptic acceptor splice site is activated and an in-frame transcript with a deletion is produced. This transcript translates into a protein with residual activity explaining the relatively mild peroxisomal abnormalities and clinical phenotype...
June 17, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/28670940/rare-%C3%AE-globin-gene-mutations-in-pakistan
#11
Ahsan Hussain, Suhaib Ahmed, Nadir Ali, Hamid S Mailk, Mariam Anees, Altaf H Chuahdry, Parvez Ahmed
The aim of this study was to analyze the rare β-thalassemia (β-thal) mutations in the Pakistani population. A total of 8716 unrelated Pakistani individuals having children with transfusion-dependent thalassemia were investigated by amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) for the previously reported common and rare β-thal mutations. Genomic sequencing of the β-globin gene and its immediate 5' and 3' flanking regions was done where no known mutation was found. Out of the 8716 individuals studied, 88 (1...
March 2017: Hemoglobin
https://www.readbyqxmd.com/read/28667829/rapid-and-simple-flow-injection-analysis-tandem-mass-spectrometric-fia-ms-ms-method-for-the-quantification-of-melphalan-in-lipid-based-drug-delivery-system
#12
Waleed Mohammed-Saeid, Deborah Michel, Ildiko Badea, Anas El-Aneed
The use of the anticancer drug melphalan is limited due to its poor water solubility. To address such limitation, it is incorporated within a novel delivery system using β-cyclodextrin-gemini surfactants (18:1βCDg). Herein, two fast and simple FIA-MS/MS methods are developed for the quantification of melphalan (Mel) within the drug delivery system so that the solubilization efficiency of the system can be assessed. FIA-MS/MS methods are developed using a triple quadrupole-linear ion trap mass spectrometer, equipped with electrospray ionization (ESI) in the positive ion mode...
July 1, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28659907/the-effect-of-phenazine-1-carboxylic-acid-on-mycelial-growth-of-botrytis-cinerea-produced-by-pseudomonas-aeruginosa-lv-strain
#13
Ane S Simionato, Miguel O P Navarro, Maria L A de Jesus, André R Barazetti, Caroline S da Silva, Glenda C Simões, Maria I Balbi-Peña, João C P de Mello, Luciano A Panagio, Ricardo S C de Almeida, Galdino Andrade, Admilton G de Oliveira
One of the most important postharvest plant pathogens that affect strawberries, grapes and tomatoes is Botrytis cinerea, known as gray mold. The fungus remains in latent form until spore germination conditions are good, making infection control difficult, causing great losses in the whole production chain. This study aimed to purify and identify phenazine-1-carboxylic acid (PCA) produced by the Pseudomonas aeruginosa LV strain and to determine its antifungal activity against B. cinerea. The compounds produced were extracted with dichloromethane and passed through a chromatographic process...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28655350/serum-biochemical-parameters-and-cytokine-profiles-associated-with-natural-african-trypanosome-infections-in-cattle
#14
Soale Majeed Bakari, Jennifer Afua Ofori, Kwadwo Asamoah Kusi, George Kwame Aning, Gordon Akanzuwine Awandare, Mark Carrington, Theresa Manful Gwira
BACKGROUND: Animal African trypanosomiasis (AAT) greatly affects livestock production in sub-Saharan Africa. In Ghana prevalence of AAT is estimated to range between 5 and 50%. Studies have reported serum biochemical aberrations and variability in cytokine profiles in animals during infection. However, information regarding the biochemical parameters and cytokine profiles associated with natural infections are limited. This study was therefore aimed at investigating changes in the levels of serum biochemical parameters and inflammatory cytokines during a natural infection...
June 27, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28655157/neuroinflammation-and-tau-interact-with-amyloid-in-predicting-sleep-problems-in-aging-independently-of-atrophy
#15
Anders Martin Fjell, Ane-Victoria Idland, Roser Sala-Llonch, Leiv Otto Watne, Tom Borza, Anne Brækhus, Tarjei Lona, Henrik Zetterberg, Kaj Blennow, Torgeir Bruun Wyller, Kristine Beate Walhovd
Sleep problems relate to brain changes in aging and disease, but the mechanisms are unknown. Studies suggest a relationship between β-amyloid (Aβ) accumulation and sleep, which is likely augmented by interactions with multiple variables. Here, we tested how different cerebrospinal fluid (CSF) biomarkers for brain pathophysiology, brain atrophy, memory function, and depressive symptoms predicted self-reported sleep patterns in 91 cognitively healthy older adults over a 3-year period. The results showed that CSF levels of total- and phosphorylated (P) tau, and YKL-40-a marker of neuroinflammation/astroglial activation-predicted poor sleep in Aβ positive older adults...
June 26, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28650326/to-evaluate-the-efficacy-and-safety-of-cofnovex-plus-ema-syrup
#16
Zubair Ali, Muhammad Daniyal, Muhammad Khalid Adhia, Anees Alam, Babar Sarfaraz, Abdul Sattar, Khan Usmanghani
The cough and cold are very widespread conditions and a common purpose for advice in general practice. Utmost often the sign and symptoms of cough are produced by acute viral airway infection and the course is frequently benign. But it can be converted into bacterial super-infection and can cause acute bronchitis. Herbal medicines are used to treat symptoms of the cough and cold, and among these medicines Ivy leaf is used to treat mucous discharge and irritation in throat due to the cough and cold. In addition to synthetic substances such as acetylcysteine, carbocisteins, ambroxol and bromhexine, herbal medicines contain saponins, which are used in these indications...
March 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28645970/the-relation-between-birthweight-childhood-body-mass-index-and-overweight-and-obesity-in-late-adolescence-a-longitudinal-cohort-study-from-norway-the-troms%C3%A3-study-fit-futures
#17
Elin Evensen, Nina Emaus, Ane Kokkvoll, Tom Wilsgaard, Anne-Sofie Furberg, Guri Skeie
OBJECTIVES: Childhood overweight/obesity is associated with later overweight/obesity. However, the association between birth weight and later overweight/obesity has not been established. The aim of this study was to investigate the relation between both birth weight and childhood body mass index (BMI), and adolescent overweight/obesity in a Norwegian population. METHODS: The Tromsø Study - Fit Futures is a population-based cohort study conducted in 2010-2011 and 2012-2013 in Tromsø, Norway...
June 22, 2017: BMJ Open
https://www.readbyqxmd.com/read/28643466/anemonin-attenuates-osteoarthritis-progression-through-inhibiting-the-activation-of-il-1%C3%AE-nf-%C3%AE%C2%BAb-pathway
#18
Zuqiang Wang, Junlan Huang, Siru Zhou, Fengtao Luo, Wei Xu, Quan Wang, Qiaoyan Tan, Liang Chen, Jun Wang, Hangang Chen, Lin Chen, Yangli Xie, Xiaolan Du
The osteoarthritis (OA) progression is now considered to be related to inflammation. Anemonin (ANE) is a small natural molecule extracted from various kinds of Chinese traditional herbs and has been shown to inhibiting inflammation response. In this study, we examined whether ANE could attenuate the progression of OA via suppression of IL-1β/NF-κB pathway activation. Destabilization of the medial meniscus (DMM) was performed in 10-week-old male C57BL/6J mice. ANE was then intra-articularly injected into joint capsule for 8 and 12 weeks...
June 23, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28642793/repair-of-thoracoabdominal-aortic-aneurysm-with-thrombosed-infrarenal-component-a-modified-hybrid-technique-without-aortic-cross-clamping
#19
Hussam Abou-Al-Shaar, Khaled J Zaza, Muhammad Anees Sharif, Samer Koussayer
The authors report the successful repair of a Crawford type III thoracoabdominal aortic aneurysm (TAAA) with a thrombosed infrarenal component using a modified hybrid technique without aortic clamping in a high-risk patient. A 64-year-old male with a history of hypertension, diabetes, and severe chronic obstructive pulmonary disease presented with acute on chronic backache and bilateral short distance claudication. A computerized tomography scan demonstrated a large, nonleaking Crawford type III TAAA with thrombosed infrarenal component of the aneurysm...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/28637706/endothelial-mineralocorticoid-receptor-contributes-to-systolic-dysfunction-induced-by-pressure-overload-without-modulating-cardiac-hypertrophy-or-inflammation
#20
Ane M Salvador, M Elizabeth Moss, Mark Aronovitz, Kathleen B Mueller, Robert M Blanton, Iris Z Jaffe, Pilar Alcaide
Heart Failure (HF) is associated with increased circulating levels of aldosterone and systemic inflammation. Mineralocorticoid receptor (MR) antagonists block aldosterone action and decrease mortality in patients with congestive HF However, the molecular mechanisms underlying the therapeutic benefits of MR antagonists remain unclear. MR is expressed in all cell types in the heart, including the endothelial cells (EC), in which aldosterone induces the expression of intercellular adhesion molecule 1 (ICAM-1)...
June 2017: Physiological Reports
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