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https://www.readbyqxmd.com/read/29351551/periodontal-health-status-and-lung-function-in-two-norwegian-cohorts
#1
Antonio Manuel Pérez Barrionuevo, Francisco Gómez Real, Jannicke Igland, Ane Johannessen, Ernst Omenaas, Karl A Franklin, Laura Pérez Barrionuevo, Anne Nordrehaug Åstrøm, Cecilie Svanes, Randi Jacobsen Bertelsen
RATIONALE AND OBJECTIVES: The oral cavity is united with the airways, and thus poor oral health may affect respiratory health. However, data on the interaction of periodontal and respiratory health is limited. We aimed to evaluate whether periodontal health status, assessed by the Community Periodontal Index (CPI), was related to lung function among young and middle-aged adults in two Norwegian cohorts. METHODS: Periodontal health status and lung function were measured among 656 participants in the Norwegian part of the European Community Respiratory Health Survey (ECHRS III) and the RHINESSA offspring study...
2018: PloS One
https://www.readbyqxmd.com/read/29348572/areca-nut-extracts-mobilize-calcium-and-release-pro-inflammatory-cytokines-from-various-immune-cells
#2
Malika Faouzi, Ram P Neupane, Jian Yang, Philip Williams, Reinhold Penner
Betel nut consumption has significant implications for the public health globally, as the wide-spread habit of Areca chewing throughout Asia and the Pacific is associated with a high prevalence of oral carcinoma and other diseases. Despite a clear causal association of betel nut chewing and oral mucosal diseases, the biological mechanisms that link Areca nut-contained molecules, inflammation and cancer remain underexplored. In this study we show that the whole Areca nut extract (ANE) is capable of mobilizing Ca2+ in various immune cell lines...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29342215/correction-seventy-years-of-asthma-in-italy-age-period-and-cohort-effects-on-incidence-and-remission-of-self-reported-asthma-from-1940-to-2010
#3
Giancarlo Pesce, Francesca Locatelli, Isa Cerveri, Massimiliano Bugiani, Pietro Pirina, Ane Johannessen, Simone Accordini, Maria Elisabetta Zanolin, Giuseppe Verlato, Roberto de Marco
[This corrects the article DOI: 10.1371/journal.pone.0138570.].
2018: PloS One
https://www.readbyqxmd.com/read/29340809/randomized-controlled-study-of-intraincisional-infiltration-versus-intraperitoneal-instillation-of-standardized-dose-of-ropivacaine-0-2-in-post-laparoscopic-cholecystectomy-pain-do-we-really-need-high-doses-of-local-anesthetics-time-to-rethink
#4
Singh Mathuria Kaushal-Deep, Afzal Anees, Shehtaj Khan, Mohammad Amanullah Khan, Mehershree Lodhi
BACKGROUND: Earlier studies done to compare the efficacy of use of local anesthetics at intraperitoneal location versus intraincisional use had utilized equal amount of drugs at the two locations, usually 10-20 ml. Using this large amount of drug in the small space of intraincisional location as compared to similar amount of drug in large intraperitoneal space created an inadvertent bias in favor of patients receiving the drug intraincisionally so these patients naturally experienced less pain...
January 16, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29339232/diapause-in-drosophila-melanogaster-photoperiodicity-cold-tolerance-and-metabolites
#5
Ane Martin Anduaga, Dora Nagy, Rodolfo Costa, Charalambos P Kyriacou
Unlike many insects where photoperiod per se induces diapause, reproductive arrest in Drosophila melanogaster adult females is observed at colder temperatures and can be enhanced by shorter photoperiods. Traditional experimental protocols raise flies at 25°C from the larval stage and then the adults are placed at 12°C for between 12 and 28 days. After 12 days diapause levels are usually higher than at 28 days, suggesting that the flies are in a cold induced quiescence, rather than a true diapause. By raising flies at more realistic lower temperatures, we observe quite dramatic and counter-intuitive effects on diapause, whose levels nevertheless correlate with various indices of cryoprotectant metabolites as well as resistance to chill shock...
January 12, 2018: Journal of Insect Physiology
https://www.readbyqxmd.com/read/29338767/effect-of-exercise-versus-cognitive-behavioural-therapy-or-no-intervention-on-anxiety-depression-fitness-and-quality-of-life-in-adults-with-previous-methamphetamine-dependency-a-systematic-review
#6
REVIEW
Linzette Morris, Jessica Stander, Wardah Ebrahim, Stephanie Eksteen, Orissa Anna Meaden, Ané Ras, Annemarie Wessels
BACKGROUND: Methamphetamine (MA) is a highly addictive psychostimulant used by approximately 52 million people worldwide. Chronic MA abuse leads to detrimental physiological and neurological changes, as well as increases in anxiety and depression, and decreases in overall fitness and quality of life. Exercise has been reported to possibly reverse physiological and neurological damage caused by previous MA use, and to reduce anxiety and depression in this population. The aim of this systematic review was to identify, clinically appraise and synthesise the available evidence for the effectiveness of exercise, compared to cognitive behavioural therapy (CBT), standard care or no intervention, on decreasing anxiety and depression and improving fitness and quality of life in previous MA users...
January 16, 2018: Addiction Science & Clinical Practice
https://www.readbyqxmd.com/read/29334622/pyridazinone-hybrids-design-synthesis-and-evaluation-as-potential-anticonvulsant-agents
#7
Sangh Partap, Md Jawaid Akhtar, Mohammed Shahar Yar, Mohd Zaheen Hassan, Anees Ahmad Siddiqui
A series of new hybrid benzothiazole containing pyridazinones derivatives were designed and synthesized fulfilling all the pharmacophoric requirements essential for the anticonvulsant activity. In-silico and in vitro studies revealed that some of these hybrid derivatives demonstrated admirable GABA AT inhibitory activity. An attempt has also been made to validate the results of in vitro GABA AT inhibition of the most potent compound SPS-5F (IC50 9.10 μM) through in vivo anticonvulsant screening. Compound SPS-5F administration significantly increases the whole brain GABA level, might be through the inhibition of GABA AT enzyme...
January 3, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29330690/extracorporeal-membrane-oxygenation-for-severe-middle-east-respiratory-syndrome-coronavirus
#8
Mohammed S Alshahrani, Anees Sindi, Fayez Alshamsi, Awad Al-Omari, Mohamed El Tahan, Bayan Alahmadi, Ahmed Zein, Naif Khatani, Fahad Al-Hameed, Sultan Alamri, Mohammed Abdelzaher, Amenah Alghamdi, Faisal Alfousan, Adel Tash, Wail Tashkandi, Rajaa Alraddadi, Kim Lewis, Mohammed Badawee, Yaseen M Arabi, Eddy Fan, Waleed Alhazzani
BACKGROUND: Middle East respiratory syndrome (MERS) is caused by a coronavirus (MERS-CoV) and is characterized by hypoxemic respiratory failure. The objective of this study is to compare the outcomes of MERS-CoV patients before and after the availability of extracorporeal membrane oxygenation (ECMO) as a rescue therapy in severely hypoxemic patients who failed conventional strategies. METHODS: We collected data retrospectively on MERS-CoV patients with refractory respiratory failure from April 2014 to December 2015 in 5 intensive care units (ICUs) in Saudi Arabia...
January 10, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29325796/lcz696-sacubitril-valsartan-an-angiotensin-receptor-neprilysin-inhibitor-attenuates-cardiac-hypertrophy-fibrosis-and-vasculopathy-in-a-rat-model-of-chronic-kidney-disease
#9
Yasunori Suematsu, Wanghui Jing, Ane Nunes, Moti L Kashyap, Mahyar Khazaeli, Nosratola D Vaziri, Hamid Moradi
BACKGROUND: Chronic kidney disease (CKD) is associated with cardiac hypertrophy, fibrosis and increased risk of cardiovascular mortality. LCZ696 (Sacubitril/valsartan) is a promising agent which has shown significant potential in treatment of heart failure. We hypothesized that LCZ696 is more effective than valsartan alone in treatment of cardiovascular abnormalities associated with experimental CKD. METHODS AND RESULTS: Male Sprague Dawley rats underwent 5/6 nephrectomy and were subsequently randomized to no treatment (CKD), 30 mg/kg valsartan (VAL), or 60 mg/kg LCZ696 (LCZ)...
January 8, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29322096/dystrophin-gene-expression-and-intracellular-calcium-changes-in-the-giant-freshwater-prawn-macrobrachium-rosenbergii-in-response-to-white-spot-symptom-disease-infection
#10
Anees Fathima Noor, Tze Chiew Christie Soo, Farhana Mohd Ghani, Zee Hong Goh, Li Teng Khoo, Subha Bhassu
Background: Dystrophin, an essential protein functional in the maintenance of muscle structural integrity is known to be responsible for muscle deterioration during white spot syndrome virus (WSSV) infection among prawn species. Previous studies have shown the upregulation of dystrophin protein in Macrobrachium rosenbergii (the giant freshwater prawn) upon white spot syndrome virus (WSSV) infection. The literature has also suggested the important role of calcium ion alterations in causing such muscle diseases...
December 2017: Heliyon
https://www.readbyqxmd.com/read/29317251/organoselenium-group-is-critical-for-antioxidant-activity-of-7-chloro-4-phenylselenyl-quinoline
#11
Ane G Vogt, Guilherme T Voss, Renata L de Oliveira, Jaini J Paltian, Luis F B Duarte, Diego Alves, Cristiano R Jesse, Silvane S Roman, Juliano A Roehrs, Ethel A Wilhelm, Cristiane Luchese
The quinolone compounds have been reported for many biological properties, especially as potent antioxidants. This study investigated the antioxidant effect of 7-chloro-4-phenylselenyl-quinoline (PSQ), a quinolone derivative with organoselenium group, against oxidative stress induced by sodium nitroprusside (SNP) in brains of mice. A second objective was to verify the importance of phenylselenyl group presents at position 4 of the quinoline structure to antioxidant effect of compound. So, it was compared the antioxidant effect of PSQ with a quinoline without organoseleniun group (7-chloroquinoline [QN])...
January 6, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29312713/outcomes-of-perioperative-extracorporeal-membrane-oxygenation-use-in-patients-undergoing-lung-transplantation
#12
Joo Han Song, Ji Eun Park, Jin Gu Lee, Chang Young Lee, Kyung Sik Nam, Jee Won Suh, Anes Kim, Seung Hyun Lee, Hyun Chel Joo, Young Nam Youn, Song Yee Kim, Moo Suk Park, Hyo Chae Paik
Background: The aim of this single-center study is to review the transplant outcomes of patients receiving lung transplantation (LTx) using intraoperative extracorporeal membrane oxygenation (ECMO) according to the perioperative use of ECMO. Methods: We retrospectively reviewed the transplant outcomes of 107 consecutive patients who underwent LTx using intraoperative ECMO between March 2013 and August 2016 at Severance Hospital of Yonsei University (Seoul, Korea)...
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29305801/electrochemical-mineralization-and-detoxification-of-naphthenic-acids-on-boron-doped-diamond-anodes
#13
Nazely Diban, Ane Urtiaga
Electrochemical oxidation (ELOX) with boron-doped diamond (BDD) anodes was successfully applied to degrade a model aqueous solution of a mixture of commercial naphthenic acids (NAs). The model mixture was prepared resembling the NA and salt composition of oil sands process-affected water (OSPW) as described in the literature. The initial concentration of NAs between 70 and 120 mg/L did not influence the electrooxidation kinetics. However, increasing the applied current density from 20 to 100 A/m2 and the initial chloride concentration from 15 to 70 and 150 mg/L accelerated the rate of NA degradation...
January 5, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29301665/parental-rheumatoid-arthritis-and-autism-spectrum-disorders-in-offspring-a-danish-nationwide-cohort%C3%A2-study
#14
Ane Lilleøre Rom, Chun Sen Wu, Jørn Olsen, Damini Jawaheer, Merete Lund Hetland, Lina Steinrud Mørch
OBJECTIVE: Maternal rheumatoid arthritis (RA) has been associated with an increased risk of autism spectrum disorder (ASD) in the offspring. We assessed the potential influence of both maternal and paternal RA on the risk of ASD in offspring to disentangle the influence of genetic inheritance from other conditions potentially leading to fetal programming. METHOD: The nationwide cohort study included all children born alive from 1977 to 2008 in Denmark (N = 1,917,723)...
January 2018: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/29296883/innate-transcriptional-effects-by-adjuvants-on-the-magnitude-quality-and-durability-of-hiv-envelope-responses-in-nhps
#15
Joseph R Francica, Daniel E Zak, Caitlyn Linde, Emilio Siena, Carrie Johnson, Michal Juraska, Nicole L Yates, Bronwyn Gunn, Ennio De Gregorio, Barbara J Flynn, Nicholas M Valiante, Padma Malyala, Susan W Barnett, Pampi Sarkar, Manmohan Singh, Siddhartha Jain, Margaret Ackerman, Munir Alam, Guido Ferrari, Georgia D Tomaras, Derek T O'Hagan, Alan Aderem, Galit Alter, Robert A Seder
Adjuvants have a critical role for improving vaccine efficacy against many pathogens, including HIV. Here, using transcriptional RNA profiling and systems serology, we assessed how distinct innate pathways altered HIV-specific antibody responses in nonhuman primates (NHPs) using 8 clinically based adjuvants. NHPs were immunized with a glycoprotein 140 HIV envelope protein (Env) and insoluble aluminum salts (alum), MF59, or adjuvant nanoemulsion (ANE) coformulated with or without Toll-like receptor 4 (TLR4) and 7 agonists...
November 28, 2017: Blood Advances
https://www.readbyqxmd.com/read/29295996/development-of-a-genetically-encodable-fret-system-using-fluorescent-rna-aptamers
#16
Mette D E Jepsen, Steffen M Sparvath, Thorbjørn B Nielsen, Ane H Langvad, Guido Grossi, Kurt V Gothelf, Ebbe S Andersen
Fluorescent RNA aptamers are useful as markers for tracking RNA molecules inside cells and for creating biosensor devices. Förster resonance energy transfer (FRET) based on fluorescent proteins has been used to detect conformational changes, however, such FRET devices have not yet been produced using fluorescent RNA aptamers. Here we develop an RNA aptamer-based FRET (apta-FRET) system using single-stranded RNA origami scaffolds. To obtain FRET, the fluorescent aptamers Spinach and Mango are placed in close proximity on the RNA scaffolds and a new fluorophore is synthesized to increase spectral overlap...
January 2, 2018: Nature Communications
https://www.readbyqxmd.com/read/29295492/on-the-impact-of-anomalous-noise-events-on-road-traffic-noise-mapping-in-urban-and-suburban-environments
#17
Ferran Orga, Francesc Alías, Rosa Ma Alsina-Pagès
Noise pollution is a critical factor affecting public health, the relationship between road traffic noise (RTN) and several diseases in urban areas being especially disturbing. The Environmental Noise Directive 2002/49/EC and the CNOSSOS-EU framework are the main instruments of the European Union to identify and combat noise pollution, requiring Member States to compose and publish noise maps and noise management action plans every five years. Nowadays, the noise maps are starting to be tailored by means of Wireless Acoustic Sensor Networks (WASN)...
December 23, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29294970/evaluation-of-parenting-interventions-to-prevent-violence-against-children-in-colombia-a-randomized-controlled-trial
#18
Ane-Marthe Solheim Skar, Lorraine Sherr, Ana Macedo, Stephen von Tetzchner, Knut Inge Fostervold
The effects of the International Child Development Programme (ICDP) and the specific addition of a violence prevention module were observed in a preidentified population in Colombia where children are experiencing high levels of violence. Participants were 176 parents of 3- to 4-year-olds attending child centers who were randomly allocated to one of three conditions: organized Community Activities at child centers and ICDP (CA + ICDP), CA, ICDP, and a preventive Violence Curriculum (CA + ICDP + VC), or a comparison group with only CA...
November 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29291498/highly-biocompatible-monodispersed-and-mesoporous-la-oh-3-eu-msio2-core-shell-nanospheres-synthesis-and-luminescent-properties
#19
Anees A Ansari, Ali Aldalbahi, Joselito P Labis, Ahmed Mohamed El-Toni, Maqusood Ahamed, M Aslam Manthrammel
Monodispersed La(OH)3:Eu nanospheres(core-NSs) were synthesized by urea-based homogeneous co-precipitation process, where mesoporous silica layer was coated over the surface of luminescent La(OH)3:Eu core-NSs. The XRD data exhibit the high crystalline, single hexagonal-shaped La(OH)3:Eu core and silica modified La(OH)3:Eu@mSiO2 (core-shell) NSs. Monodispersibility, spherical shaped, high surface area and mesoporosity were identified by TEM analysis and were further confirmed by BET analysis. The as-synthesized samples are highly soluble in aqueous media at ambient conditions...
December 16, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29288190/can-we-save-the-rectum-by-watchful-waiting-or-transanal-microsurgery-following-chemo-radiotherapy-versus-total-mesorectal-excision-for-early-rectal-cancer-star-trec-study-protocol-for-a-multicentre-randomised-feasibility-study
#20
Anouk J M Rombouts, Issam Al-Najami, Natalie L Abbott, Ane Appelt, Gunnar Baatrup, Simon Bach, Aneel Bhangu, Karen-Lise Garm Spindler, Richard Gray, Kelly Handley, Manjinder Kaur, Ellen Kerkhof, Camilla Jensenius Kronborg, Laura Magill, Corrie A M Marijnen, Iris D Nagtegaal, Lars Nyvang, Femke P Peters, Per Pfeiffer, Cornelis Punt, Philip Quirke, David Sebag-Montefiore, Mark Teo, Nick West, Johannes H W de Wilt
INTRODUCTION: Total mesorectal excision (TME) is the highly effective standard treatment for rectal cancer but is associated with significant morbidity and may be overtreatment for low-risk cancers. This study is designed to determine the feasibility of international recruitment in a study comparing organ-saving approaches versus standard TME surgery. METHODS AND ANALYSIS: STAR-TREC trial is a multicentre international randomised, three-arm parallel, phase II feasibility study in patients with biopsy-proven adenocarcinoma of the rectum...
December 28, 2017: BMJ Open
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