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https://www.readbyqxmd.com/read/27925228/a-mock-circulatory-system-incorporating-a-compliant-3d-printed-anatomical-model-to-investigate-pulmonary-hemodynamics
#1
Paul G M Knoops, Giovanni Biglino, Alun D Hughes, Kim H Parker, Linzhang Xu, Silvia Schievano, Ryo Torii
A realistic mock circulatory system (MCS) could be a valuable in vitro testbed to study human circulatory hemodynamics. The objective of this study was to design a MCS replicating the pulmonary arterial circulation, incorporating an anatomically representative arterial model suitable for testing clinically relevant scenarios. A second objective of the study was to ensure the system's compatibility with magnetic resonance imaging (MRI) for additional measurements. A latex pulmonary arterial model with two generations of bifurcations was manufactured starting from a 3D-printed mold reconstructed from patient data...
December 7, 2016: Artificial Organs
https://www.readbyqxmd.com/read/27915978/cell-compatibility-of-an-eposimal-vector-mediated-by-the-characteristic-motifs-of-matrix-attachment-regions
#2
Tian-Yun Wang, Li Wang, Yu-Xin Yang, Chun-Peng Zhao, Yan-Long Jia, Qin Li, Jun-He Zhang, Yi-You Peng, Miao Wang, Hong-Yan Xu, Xiao-Yin Wang
The characteristic sequence of β-interferon matrix attachment regions (MARs) can mediate transgene expression via episomal vectors in Chinese hamster ovary (CHO) cells. However, the host cells were from hamster ovaries, which are not suitable target cells for gene therapy. In this study, we aimed to evaluate the suitability of 12 different human cell lines as target cells for gene therapy. We transfected the cells with episomal vectors and obtained colonies stably expressing the vector products after G418 screening...
December 2, 2016: Current Gene Therapy
https://www.readbyqxmd.com/read/27913440/optical-coherence-tomographic-angiography-of-choroidal-neovascularization-ill-defined-with-fluorescein-angiography
#3
Mehrdad Malihi, Yali Jia, Simon S Gao, Christina Flaxel, Andreas K Lauer, Thomas Hwang, David J Wilson, David Huang, Steven T Bailey
PURPOSE: To evaluate the morphological structure of ill-defined choroidal neovascularisation (CNV) with traditional fluorescein angiography (FA) compared with optical coherence tomographic angiography (OCTA). METHODS: A retrospective case series study of 11 eyes with ill-defined CNV on FA was performed. Eyes were scanned with commercially available spectral-domain optical coherence tomography (OCT) (70 000 A-scans/s). The split-spectrum amplitude-decorrelation angiography (SSADA) algorithm was used to distinguish blood flow from static tissue...
December 2, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27910958/switchable-3d-optofluidic-y-branch-waveguides-tuned-by-dean-flows
#4
L Li, X Q Zhu, L Liang, Y F Zuo, Y S Xu, Y Yang, Y J Yuan, Q Q Huang
Optical branch waveguides are one of the most important optical elements and have been widely exploited for optical communication systems. However, prevailing devices are typically solid and have limit in tunability. Liquid optical devices have attracted more interest for the advantage of tunability of liquid media, but their signals suffer serious leakage if the refractive index (RI) of liquid is smaller than that of solid channels. This paper demonstrates the tunable three-dimensional (3D) optofluidic Y-branch waveguides in plannar microchannels by simply introducing Dean flow...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27910412/dual-wavelength-imaging-of-a-scrape-off-layer-in-an-advanced-beam-driven-field-reversed-configuration
#5
D Osin, T Schindler
A dual wavelength imaging system has been developed and installed on C-2U to capture 2D images of a He jet in the Scrape-Off Layer (SOL) of an advanced beam-driven Field-Reversed Configuration (FRC) plasma. The system was designed to optically split two identical images and pass them through 1 nm FWHM filters. Dual wavelength images are focused adjacent on a large format CCD chip and recorded simultaneously with a time resolution down to 10 μs using a gated micro-channel plate. The relatively compact optical system images a 10 cm plasma region with a spatial resolution of 0...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27893722/valley-photonic-crystals-for-control-of-spin-and%C3%A2-topology
#6
Jian-Wen Dong, Xiao-Dong Chen, Hanyu Zhu, Yuan Wang, Xiang Zhang
Photonic crystals offer unprecedented opportunity for light manipulation and applications in optical communication and sensing. Exploration of topology in photonic crystals and metamaterials with non-zero gauge field has inspired a number of intriguing optical phenomena such as one-way transport and Weyl points. Recently, a new degree of freedom, valley, has been demonstrated in two-dimensional materials. Here, we propose a concept of valley photonic crystals with electromagnetic duality symmetry but broken inversion symmetry...
November 28, 2016: Nature Materials
https://www.readbyqxmd.com/read/27889871/genetic-relationships-and-spatial-genetic-structure-among-populations-of-rhodnius-prolixus-hemiptera-reduviidae-in-colombia-and-venezuela-based-on-mitochondrial-cytochrome-b-sequences
#7
K P Luna-Marín, V M Angulo-Silva, J Hernández-Torres, M Ruiz-García
One hundred twenty Rhodnius prolixus (Stal) (Hemiptera: Reduviidae) specimens from 6 Colombian Departments and 1 Venezuelan State had 594-bp of the mitochondrial cytochrome-b gene sequenced to improve the understanding of evolutionary processes that shape the main vector of Chagas disease. The levels of genetic diversity for this species were low-medium with reference to other bugs. The genetic heterogeneity among the populations was very limited which means there has been extensive gene flow and/or very recent split processes...
November 26, 2016: Neotropical Entomology
https://www.readbyqxmd.com/read/27878419/split-renal-function-of-both-kidneys-after-robot-assisted-partial-nephrectomy-for-renal-tumor-larger-than-4%C3%A2-cm
#8
Sheng-Han Tsai, Yi-Chen Lai, Nai-Yuan Wu, Hsiao-Jen Chung
PURPOSE: Relative few studies reported the changes in split renal function using renal scintigraphy for robot-assisted partial nephrectomy (RaPN) for renal tumor >4 cm. This study aimed at demonstrating that RaPN is safe for renal tumor >4 cm without damaging the renal function of ipsilateral and contralateral kidney. METHODS: Patients who underwent RaPN for single renal tumor from December 2009 to December 2013 were identified from a prospectively collected database...
November 22, 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/27876561/tip-design-of-hemodialysis-catheters-influences-thrombotic-events-and-replacement-rate
#9
C Petridis, M Nitschke, W Lehne, E Smith, J P Goltz, H Lehnert, M Meier
OBJECTIVE/BACKGROUND: Central venous tunnelled hemodialysis catheters (CVTC) are used for initial vascular access in patients with renal failure. Tip design of the CVTC may play an important role in catheter function and complication rates, influencing adequate hemodialysis treatment of these patients. METHODS: This prospective, observational cohort study compared the function and complication rates of two CVTCs in patients with end stage renal disease (ESRD) within a follow-up period of 24 months...
November 19, 2016: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/27867728/label-free-measurement-of-retinal-blood-cell-flux-velocity-hematocrit-and-capillary-width-in-the-living-mouse-eye
#10
A Guevara-Torres, A Joseph, J B Schallek
Measuring blood cell dynamics within the capillaries of the living eye provides crucial information regarding the health of the microvascular network. To date, the study of single blood cell movement in this network has been obscured by optical aberrations, hindered by weak optical contrast, and often required injection of exogenous fluorescent dyes to perform measurements. Here we present a new strategy to non-invasively image single blood cells in the living mouse eye without contrast agents. Eye aberrations were corrected with an adaptive optics camera coupled with a fast, 15 kHz scanned beam orthogonal to a capillary of interest...
October 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27866675/hemodynamics-of-patient-specific-aorta-pulmonary-shunt-configurations
#11
Senol Piskin, H Firat Altin, Okan Yildiz, Ihsan Bakir, Kerem Pekkan
Optimal hemodynamics in aorta-pulmonary shunt reconstruction is essential for improved post-operative recovery of the newborn congenital heart disease patient. However, prior to in vivo execution, the prediction of post-operative hemodynamics is extremely challenging due to the interplay of multiple confounding physiological factors. It is hypothesized that the post-operative performance of the surgical shunt can be predicted through computational blood flow simulations that consider patient size, shunt configuration, cardiac output and the complex three-dimensional disease anatomy...
November 11, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/27864444/simultaneous-burst-imaging-of-dual-species-using-planar-laser-induced-fluorescence-at-50%C3%A2-khz-in-turbulent-premixed-flames
#12
Zheming Li, Joakim Rosell, Marcus Aldén, Mattias Richter
Spatially and temporally resolved measurements are of great importance in turbulent premixed flame studies, especially when investigating rapid processes such as when flame local extinction, re-ignition, or flashback occur in a reacting flow. Here, an experimental approach for simultaneously probing two different species at high frame rates (50 kHz) is presented by employing a multi-YAG laser system. The laser radiation at 355 nm generated by a multi-YAG laser system was split into two beam paths: one beam for exciting formaldehyde and the other for pumping an optical parametric oscillator (OPO)...
November 18, 2016: Applied Spectroscopy
https://www.readbyqxmd.com/read/27853339/experimental-demonstration-of-the-thermochemical-reduction-of-ceria-in-a-solar-aerosol-reactor
#13
Michael Welte, Rafik Barhoumi, Adrian Zbinden, Jonathan R Scheffe, Aldo Steinfeld
We report on the experimental demonstration of an aerosol solar reactor for the thermal reduction of ceria, as part of a thermochemical redox cycle for splitting H2O and CO2. The concept utilizes a cavity-receiver enclosing an array of alumina tubes, each containing a downward gravity-driven aerosol flow of ceria particles countercurrent to an inert sweep gas flow for intrinsic separation of reduced ceria and oxygen. A 2 kWth lab-scale prototype with a single tube was tested under radiative fluxes approaching 4000 suns, yielding reaction extents of up to 53% of the thermodynamic equilibrium at 1919 K within residence times below 1 s...
October 12, 2016: Industrial & Engineering Chemistry Research
https://www.readbyqxmd.com/read/27846268/application-of-rad-sequencing-for-evaluating-the-genetic-diversity-of-domesticated-panax-notoginseng-araliaceae
#14
Yuezhi Pan, Xueqin Wang, Guiling Sun, Fusheng Li, Xun Gong
Panax notoginseng, a traditional Chinese medicinal plant, has been cultivated and domesticated for approximately 400 years, mainly in Yunnan and Guangxi, two provinces in southwest China. This species was named according to cultivated rather than wild individuals, and no wild populations had been found until now. The genetic resources available on farms are important for both breeding practices and resource conservation. In the present study, the recently developed technology RADseq, which is based on next-generation sequencing, was used to analyze the genetic variation and differentiation of P...
2016: PloS One
https://www.readbyqxmd.com/read/27821106/aberrant-activation-of-notch-signaling-in-extrahepatic-cholangiocarcinoma-clinicopathological-features-and-therapeutic-potential-for-cancer-stem-cell-like-properties
#15
Shuichi Aoki, Masamichi Mizuma, Yayoi Takahashi, Yoichi Haji, Ryo Okada, Tomoya Abe, Hideaki Karasawa, Keiichi Tamai, Takaho Okada, Takanori Morikawa, Hiroki Hayashi, Kei Nakagawa, Fuyuhiko Motoi, Takeshi Naitoh, Yu Katayose, Michiaki Unno
BACKGROUND: Little is known about the roles of Notch signaling in cholangiocarcinoma (CC). The expression of hairy and enhancer of split 1 (Hes-1) has not been investigated yet in resected specimens of CC. Notch signaling has been reported to be related to cancer stem cell (CSC) like properties in some malignancies. Our aim is to investigate the participation of Notch signaling in resected specimens of extrahepatic CC (EHCC) and to evaluate the efficacy of CC cells with CSC-like properties by Notch signaling blockade...
November 7, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27813141/renal-deterioration-after-spinal-cord-injury-is-associated-with-length-of-detrusor-contractions-during-cystometry-a-study-with-a-median-of-41-years-follow-up
#16
Marlene Elmelund, Niels Klarskov, Per Bagi, Peter S Oturai, Fin Biering-Sørensen
AIMS: To investigate which urodynamic parameters are associated with renal deterioration over a median of 41 years follow-up after traumatic spinal cord injury. METHODS: Medical records of patients with a traumatic spinal cord injury sustained 1944-1975 were reviewed from time of injury until 2012. Patients who attended regular renography and/or renal clearance examinations and had minimum one cystometry and pressure-flow study were included. Renal deterioration was diagnosed as split renal function ≤30% in one kidney or relative glomerular filtration rate ≤51% of expected according to age and gender...
November 4, 2016: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/27812908/liver-transplantation-in-infants-with-biliary-atresia-comparison-of-primary-versus-temporary-abdominal-closure
#17
Nagoud Schukfeh, Anna-Charlotte Holland, Dieter P Hoyer, Anja Gallinat, Andreas Paul, Maren Schulze
INTRODUCTION: Biliary atresia (BA) is the most frequent disease leading to liver transplantation (LT) in infants. Since the patients often require transplantation before reaching a body weight of 10 kg, it is necessary to perform living-related or split liver transplantation by using a left lateral segment. However, this graft often exceeds a graft body weight ratio (GBWR) of 4. Because of the size mismatch and poor portal venous blood flow in most recipients, temporary abdominal closure is often favoured...
November 3, 2016: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/27811770/a-new-member-of-the-greater-double-collared-sunbird-complex-passeriformes-nectariniidae-from-the-eastern-arc-mountains-of-africa
#18
Rauri C K Bowie, Jon Fjeldså, Jacob Kiure, Jan Bolding Kristensen
We document the discovery of the first population of greater double-collared sunbird (Cinnyris afer complex) from the Eastern Arc Mountains of Tanzania. We assessed phylogenetic relationships and taxonomic rank based on mtDNA sequence data, nine microsatellite loci and morphology. This new taxon, locally distributed in the Rubeho and Udzungwa Highlands, has close affinities (< 1% uncorrected sequence divergence) with C. whytei (split here from C. ludovicensis) of the Nyika Plateau in Malawi, but differs in having longer tarsi and in subtle plumage details...
October 12, 2016: Zootaxa
https://www.readbyqxmd.com/read/27807275/predicting-false-lumen-thrombosis-in-patient-specific-models-of-aortic-dissection
#19
Claudia Menichini, Zhuo Cheng, Richard G J Gibbs, Xiao Yun Xu
Aortic dissection causes splitting of the aortic wall layers, allowing blood to enter a 'false lumen' (FL). For type B dissection, a significant predictor of patient outcomes is patency or thrombosis of the FL. Yet, no methods are currently available to assess the chances of FL thrombosis. In this study, we present a new computational model that is capable of predicting thrombus formation, growth and its effects on blood flow under physiological conditions. Predictions of thrombus formation and growth are based on fluid shear rate, residence time and platelet distribution, which are evaluated through convection-diffusion-reaction transport equations...
November 2016: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/27802687/measuring-10-20-t-magnetic-fields-in-single-wire-explosions-using-zeeman-splitting
#20
J T Banasek, J T Engelbrecht, S A Pikuz, T A Shelkovenko, D A Hammer
We have shown that the Zeeman splitting of the sodium (Na) D-lines at 5890 Å and 5896 Å can be used to measure the magnetic field produced by the current flowing in an exploding wire prior to wire explosion. After wire explosion, the lines in question are either not visible in the strong continuum from the exploding wire plasma, or too broad to measure the magnetic field by methods discussed in this paper. We have determined magnetic fields in the range 10-20 T, which lies between the small field and Paschen-Back regimes for the Na D-lines, over a period of about 70 ns on a 10 kA peak current machine...
October 2016: Review of Scientific Instruments
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