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https://www.readbyqxmd.com/read/29352674/the-effect-of-vertical-split-flow-patient-management-on-emergency-department-throughput-and-efficiency
#1
John S Garrett, Colyn Berry, Hao Wong, Huanying Qin, Jeffery A Kline
BACKGROUND: To address emergency department overcrowding operational research seeks to identify efficient processes to optimize flow of patients through the emergency department. Vertical flow refers to the concept of utilizing and assigning patients virtual beds rather than to an actual physical space within the emergency department to care of low acuity patients. The aim of this study is to evaluate the impact of vertical flow upon emergency department efficiency and patient satisfaction...
January 11, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29349475/continuous-splitting-of-aqueous-droplets-at-the-interface-of-co-flowing-immiscible-oil-streams-in-a-microchannel
#2
K S Jayaprakash, A K Sen
We report the continuous splitting of aqueous droplets at the interface between two co-flowing immiscible oil streams in a microchannel. The aqueous droplets initially present in a primary continuous stream (CP1) migrate into a secondary continuous stream (CP2) when the ratio of the non-inertial lift force to the interfacial tension force exceeds a critical value (K. S. Jayaprakash, U. Banerjee and A. K. Sen, Langmuir, 2016, 32, 2136-2143). Here, experiments were performed to understand the droplet splitting phenomenon and demonstrate the splitting of droplets encapsulating microbeads and cells...
January 19, 2018: Soft Matter
https://www.readbyqxmd.com/read/29347691/dynamics-of-functional-failures-and-recovery-in-complex-road-networks
#3
Xianyuan Zhan, Satish V Ukkusuri, P Suresh C Rao
We propose a new framework for modeling the evolution of functional failures and recoveries in complex networks, with traffic congestion on road networks as the case study. Differently from conventional approaches, we transform the evolution of functional states into an equivalent dynamic structural process: dual-vertex splitting and coalescing embedded within the original network structure. The proposed model successfully explains traffic congestion and recovery patterns at the city scale based on high-resolution data from two megacities...
November 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347383/wavelet-based-regularization-of-the-galerkin-truncated-three-dimensional-incompressible-euler-flows
#4
Marie Farge, Naoya Okamoto, Kai Schneider, Katsunori Yoshimatsu
We present numerical simulations of the three-dimensional Galerkin truncated incompressible Euler equations that we integrate in time while regularizing the solution by applying a wavelet-based denoising. For this, at each time step, the vorticity field is decomposed into wavelet coefficients, which are split into strong and weak coefficients, before reconstructing them in physical space to obtain the corresponding coherent and incoherent vorticities. Both components are multiscale and orthogonal to each other...
December 2017: Physical Review. E
https://www.readbyqxmd.com/read/29346906/smoothed-particle-hydrodynamics-method-for-evaporating-multiphase-flows
#5
Xiufeng Yang, Song-Charng Kong
The smoothed particle hydrodynamics (SPH) method has been increasingly used for simulating fluid flows; however, its ability to simulate evaporating flow requires significant improvements. This paper proposes an SPH method for evaporating multiphase flows. The present SPH method can simulate the heat and mass transfers across the liquid-gas interfaces. The conservation equations of mass, momentum, and energy were reformulated based on SPH, then were used to govern the fluid flow and heat transfer in both the liquid and gas phases...
September 2017: Physical Review. E
https://www.readbyqxmd.com/read/29331222/on-tubing-fluorescence-measurements-of-the-band-broadening-of-contemporary-injectors-in-ultra-high-performance-liquid-chromatography
#6
Ken Broeckhoven, Kim Vanderlinden, Davy Guillarme, Gert Desmet
We report on a detailed study of the injection contribution to band broadening in contemporary UHPLC-instruments, using either flow-through needle or fixed loop injection (full loop). Using on-tubing fluorescence measurements at the outlet of the injector valve, very localized and undisturbed measurements were obtained. Varying both the flow rate and the injected volume allowed to split the injection variance (σV2,inj) in a volumetric component (related to the amount injected) and a hydrodynamic component (related to the flow rate)...
December 15, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29324559/nurse-experiences-of-medication-administration-to-people-with-swallowing-difficulties-living-in-aged-care-facilities-a-systematic-review-of-qualitative-evidence
#7
Aida Sefidani Forough, Simon Y M Wong, Esther T L Lau, Jose Manuel Serrano Santos, Greg J Kyle, Kathryn J Steadman, Julie A Y Cichero, Lisa M Nissen
OBJECTIVE: To identify nurses' experiences of administering oral medications to residents of aged care facilities (ACFs) with swallowing difficulties. INTRODUCTION: Administering medicines to older people with swallowing difficulties is a challenging task. Nurses frequently modify oral medications e.g. by crushing/splitting tablets or opening capsules, to facilitate the administration process. These practices are associated with an increased risk of medication administration errors...
January 2018: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29323294/terminal-pleistocene-alaskan-genome-reveals-first-founding-population-of-native-americans
#8
J Víctor Moreno-Mayar, Ben A Potter, Lasse Vinner, Matthias Steinrücken, Simon Rasmussen, Jonathan Terhorst, John A Kamm, Anders Albrechtsen, Anna-Sapfo Malaspinas, Martin Sikora, Joshua D Reuther, Joel D Irish, Ripan S Malhi, Ludovic Orlando, Yun S Song, Rasmus Nielsen, David J Meltzer, Eske Willerslev
Despite broad agreement that the Americas were initially populated via Beringia, the land bridge that connected far northeast Asia with northwestern North America during the Pleistocene epoch, when and how the peopling of the Americas occurred remains unresolved. Analyses of human remains from Late Pleistocene Alaska are important to resolving the timing and dispersal of these populations. The remains of two infants were recovered at Upward Sun River (USR), and have been dated to around 11.5 thousand years ago (ka)...
January 11, 2018: Nature
https://www.readbyqxmd.com/read/29289140/large-scale-brownian-dynamics-of-confined-suspensions-of-rigid-particles
#9
Brennan Sprinkle, Florencio Balboa Usabiaga, Neelesh A Patankar, Aleksandar Donev
We introduce methods for large-scale Brownian Dynamics (BD) simulation of many rigid particles of arbitrary shape suspended in a fluctuating fluid. Our method adds Brownian motion to the rigid multiblob method [F. Balboa Usabiaga et al., Commun. Appl. Math. Comput. Sci. 11(2), 217-296 (2016)] at a cost comparable to the cost of deterministic simulations. We demonstrate that we can efficiently generate deterministic and random displacements for many particles using preconditioned Krylov iterative methods, if kernel methods to efficiently compute the action of the Rotne-Prager-Yamakawa (RPY) mobility matrix and its "square" root are available for the given boundary conditions...
December 28, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29286410/an-engineered-split-tet2-enzyme-for-chemical-inducible-dna-hydroxymethylation-and-epigenetic-remodeling
#10
Minjung Lee, Yubin Zhou, Yun Huang
DNA methylation is a stable and heritable epigenetic modification in the mammalian genome and is involved in regulating gene expression to control cellular functions. The reversal of DNA methylation, or DNA demethylation, is mediated by the ten-eleven translocation (TET) protein family of dioxygenases. Although it has been widely reported that aberrant DNA methylation and demethylation are associated with developmental defects and cancer, how these epigenetic changes directly contribute to the subsequent alteration in gene expression or disease progression remains unclear, largely owing to the lack of reliable tools to accurately add or remove DNA modifications in the genome at defined temporal and spatial resolution...
December 18, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29276885/flow-cytometric-bead-sandwich-assay-based-on-split-aptamer
#11
Luyao Shen, Tao Bing, Xiangjun Liu, Junyan Wang, Linlin Wang, Nan Zhang, Dihua Shangguan
A few aptamers still bind their targets after being split into two moieties. Split aptamers have shown great potential in the development of aptameric sensors. However, only a few split aptamers have been generated because of lack of knowledge on the binding structure of their parent aptamers. Here, we report the design of a new split aptamer and a flow cytometric bead sandwich assay using a split aptamer instead of double antibodies. Through DMS footprinting and mutation assay, we figured out the target-binding moiety and the structure-stabilizing moiety of the L-selectin aptamer, Sgc-3b...
December 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29275614/-wound-repair-and-functional-reconstruction-of-high-voltage-electrical-burns-in-wrists
#12
Y M Shen, C X Ma, F J Qin, C Zhang, C Wang, X H Hu
Objective: To explore the methods and effects of wound repair and functional reconstruction of high-voltage electrical burns in wrists. Methods: From January 2009 to June 2016, 71 patients with high-voltage electrical burns in wrists were hospitalized, with 118 wrist wounds including 21 of type Ⅰ, 69 of type Ⅱ, 9 of type Ⅲ, and 19 of type Ⅳ. According to the wrist injuries, different surgical operations were performed. Forearm amputation was conducted in 20 wrists with necrosis in the distal end. On the basis of fasciotomy for decompression, early debridement was performed on the other 98 wrist wounds...
December 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29274204/coupling-nanoliter-high-performance-liquid-chromatography-to-inductively-coupled-plasma-mass-spectrometry-for-arsenic-speciation
#13
Heyong Cheng, Lihuan Shen, Jinhua Liu, Zigang Xu, Yuanchao Wang
Nanoliter high-performance liquid chromatography shows a low consumption of solvents and samples, offering one of the best choices for arsenic speciation in precious samples in combining with inductively coupled plasma mass spectrometry. A systematic investigation on coupling nanoliter high-performance liquid chromatography to inductively coupled plasma mass spectrometry from the instrumentation design, injected sample volume to mobile phases was performed in this study. Nanoflow mobile phase was delivered by flow splitting using conventional high-pressure pump with reuse of mobile phase waste...
December 23, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29238548/energy-and-speleogenesis-key-determinants-of-terrestrial-species-richness-in-caves
#14
Alberto Jiménez-Valverde, Alberto Sendra, Policarp Garay, Ana Sofia P S Reboleira
The aim of this study was to unravel the relative role played by speleogenesis (i.e., the process in which a cave is formed), landscape-scale variables, and geophysical factors in the determination of species richness in caves. Biological inventories from 21 caves located in the southeastern Iberian Peninsula along with partial least square (PLS) regression analysis were used to assess the relative importance of the different explanatory variables. The caves were grouped according to the similarity in their species composition; the effect that spatial distance could have on similarity was also studied using correlation between matrices...
December 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29234166/the-iicr-inverse-instantaneous-coalescence-rate-as-a-summary-of-genomic-diversity-insights-into-demographic-inference-and-model-choice
#15
Lounès Chikhi, Willy Rodríguez, Simona Grusea, Patrícia Santos, Simon Boitard, Olivier Mazet
Several inferential methods using genomic data have been proposed to quantify and date population size changes in the history of species. At the same time an increasing number of studies have shown that population structure can generate spurious signals of population size change. Recently, Mazet et al. (2016) introduced, for a sample size of two, a time-dependent parameter, which they called the IICR (inverse instantaneous coalescence rate). The IICR is equivalent to a population size in panmictic models, but not necessarily in structured models...
January 2018: Heredity
https://www.readbyqxmd.com/read/29220376/c5a-and-c5ar-are-elevated-in-joints-of-rheumatoid-and-psoriatic-arthritis-patients-and-c5ar-blockade-attenuates-leukocyte-migration-to-synovial-fluid
#16
Lars Hornum, Anker Jon Hansen, Ditte Tornehave, Marianne Scheel Fjording, Paula Colmenero, Inger Falbe Wätjen, Niels Henrik Søe Nielsen, Henning Bliddal, Else Marie Bartels
Complement activation correlates to rheumatoid arthritis disease activity, and increased amounts of the complement split product C5a is observed in synovial fluids from rheumatoid arthritis patients. Blockade of C5a or its receptor (C5aR) is efficacious in several arthritis models. The aim of this study was to investigate the role of C5a and C5aR in human rheumatoid arthritis and psoriatic arthritis-both with respect to expression and function. Synovial fluid, blood and synovial samples were obtained from rheumatoid arthritis, psoriatic arthritis and osteoarthritis patients as a less inflammatory arthritis type, and blood from healthy subjects...
2017: PloS One
https://www.readbyqxmd.com/read/29220055/on-demand-acoustic-droplet-splitting-and-steering-in-a-disposable-microfluidic-chip
#17
Jinsoo Park, Jin Ho Jung, Kwangseok Park, Ghulam Destgeer, Husnain Ahmed, Raheel Ahmad, Hyung Jin Sung
On-chip droplet splitting is one of the fundamental droplet-based microfluidic unit operations to control droplet volume after production and increase operational capability, flexibility, and throughput. Various droplet splitting methods have been proposed, and among them the acoustic droplet splitting method is promising because of its label-free operation without any physical or thermal damage to droplets. Previous acoustic droplet splitting methods faced several limitations: first, they employed a cross-type acoustofluidic device that precluded multichannel droplet splitting; second, they required irreversible bonding between a piezoelectric substrate and a microfluidic chip, such that the fluidic chip was not replaceable...
December 8, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/29219204/textile-inspired-lithium-oxygen-battery-cathode-with-decoupled-oxygen-and-electrolyte-pathways
#18
Shaomao Xu, Yonggang Yao, Yuanyuan Guo, Xiaoqiao Zeng, Steven D Lacey, Huiyu Song, Chaoji Chen, Yiju Li, Jiaqi Dai, Yanbin Wang, Yanan Chen, Boyang Liu, Kun Fu, Khalil Amine, Jun Lu, Liangbing Hu
The lithium-air (Li-O2 ) battery has been deemed one of the most promising next-generation energy-storage devices due to its ultrahigh energy density. However, in conventional porous carbon-air cathodes, the oxygen gas and electrolyte often compete for transport pathways, which limit battery performance. Here, a novel textile-based air cathode is developed with a triple-phase structure to improve overall battery performance. The hierarchical structure of the conductive textile network leads to decoupled pathways for oxygen gas and electrolyte: oxygen flows through the woven mesh while the electrolyte diffuses along the textile fibers...
December 8, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29215207/integration-of-plasmonic-effects-and-schottky-junctions-into-metal-organic-framework-composites-steering-charge-flow-for-enhanced-visible-light-photocatalysis
#19
Juan-Ding Xiao, Lili Han, Jun Luo, Shu-Hong Yu, Hai-Long Jiang
A wide range of light absorption and rapid electron-hole separation are desired for efficient photocatalysis. Herein, on the basis of a semiconductor-like metal-organic framework (MOF), a Pt@MOF/Au catalyst with two types of metal-MOF interfaces integrates the surface plasmon resonance excitation of Au nanorods with a Pt-MOF Schottky junction, which not only extends the light absorption of the MOF from the UV to the visible region but also greatly accelerates charge transfer. The spatial separation of Pt and Au particles by the MOF further steers the formation of charge flow and expedites the charge migration...
December 7, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29209348/phylogeography-study-of-the-siberian-apricot-prunus-sibirica-l-in-northern-china-assessed-by-chloroplast-microsatellite-and-dna-makers
#20
Zhe Wang, Yanfei Zeng, Zhendong Zhang, Songbai Sheng, Ju Tian, Rongling Wu, Xiaoming Pang
There is evidence that a band of dry climate separated plants in East Asia into distinct northern and southern groups. However, few studies have focused on the arid belt in this region, especially with regard to plants. We analyzed genetic variation in 22 populations of Siberian apricot (Prunus sibirica L.), a temperate deciduous species distributed in this arid belt, using two chloroplast DNA (cpDNA) sequences, seven chloroplast microsatellite loci (cpSSRs), and 31 nuclear microsatellite loci (nSSRs), to study its phylogeography...
2017: Frontiers in Plant Science
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