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Neel Shah

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https://www.readbyqxmd.com/read/27862256/cost-analysis-of-following-up-incomplete-low-risk-fetal-anatomy-ultrasounds
#1
Karen O'Brien, Scott A Shainker, Anna M Modest, Melissa H Spiel, Nina Resetkova, Neel Shah, Michele R Hacker
OBJECTIVES: To examine the clinical utility and cost of follow-up ultrasounds performed as a result of suboptimal views at the time of initial second-trimester ultrasound in a cohort of low-risk pregnant women. METHODS: We conducted a retrospective cohort study of women at low risk for fetal structural anomalies who had second-trimester ultrasounds at 16 to less than 24 weeks of gestation from 2011 to 2013. We determined the probability of women having follow-up ultrasounds as a result of suboptimal views at the time of the initial second-trimester ultrasound, and calculated the probability of detecting an anomaly on follow-up ultrasound...
November 15, 2016: Birth
https://www.readbyqxmd.com/read/27757919/comparing-biologic-cost-per-treated-patient-across-indications-among-adult-us-managed-care-patients-a-retrospective-cohort-study
#2
Tao Gu, Neel Shah, Gaurav Deshpande, Derek H Tang, Debra F Eisenberg
BACKGROUND: The relative cost of biologics in the treatment of autoimmune disorders, including rheumatoid arthritis, psoriatic arthritis, psoriasis, and ankylosing spondylitis, is a key consideration for managed care payers. OBJECTIVES: Our objective was to estimate biologic costs and treatment patterns in US managed care patients with rheumatoid arthritis, psoriatic arthritis, psoriasis, and/or ankylosing spondylitis. METHODS: This retrospective study used administrative claims data from the HealthCore Integrated Research Database (HIRD(SM)) for adults with rheumatoid arthritis, psoriatic arthritis, psoriasis, and/or ankylosing spondylitis who received abatacept, adalimumab, certolizumab, etanercept, golimumab, infliximab, rituximab, tocilizumab, or ustekinumab between 1 July 2009 and 31 January 2013...
December 2016: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/27700984/an-electrostatic-selection-mechanism-controls-sequential-kinase-signaling-downstream-of-the-t-cell-receptor
#3
Neel H Shah, Qi Wang, Qingrong Yan, Deepti Karandur, Theresa A Kadlecek, Ian R Fallahee, William P Russ, Rama Ranganathan, Arthur Weiss, John Kuriyan
The sequence of events that initiates T cell signaling is dictated by the specificities and order of activation of the tyrosine kinases that signal downstream of the T cell receptor. Using a platform that combines exhaustive point-mutagenesis of peptide substrates, bacterial surface-display, cell sorting, and deep sequencing, we have defined the specificities of the first two kinases in this pathway, Lck and ZAP-70, for the T cell receptor ζ chain and the scaffold proteins LAT and SLP-76. We find that ZAP-70 selects its substrates by utilizing an electrostatic mechanism that excludes substrates with positively-charged residues and favors LAT and SLP-76 phosphosites that are surrounded by negatively-charged residues...
October 4, 2016: ELife
https://www.readbyqxmd.com/read/27698450/1-25-oh-2d3-treatment-alters-the-granulomatous-response-in-m-tuberculosis-infected-mice
#4
Kamlesh Bhatt, Wasiulla Rafi, Neel Shah, Sylvia Christakos, Padmini Salgame
Induction of cathelicidin-mediated antimicrobial pathway against intracellular M. tuberculosis by 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), the active form of vitamin D, has been documented in vitro. However, in in vivo studies related to inflammatory disorders, 1,25(OH)2D3 has been demonstrated to induce an anti-inflammatory response. We therefore examined whether in the murine model of tuberculosis, the anti-inflammatory effects of 1,25(OH)2D3 would affect the outcome of M. tuberculosis infection. We show here that administration of 1,25(OH)2D3 to M...
October 4, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27686459/esicm-lives-2016-part-three-milan-italy-1-5-october-2016
#5
T Velasquez, G Mackey, J Lusk, U G Kyle, T Fontenot, P Marshall, L S Shekerdemian, J A Coss-Bu, A Nishigaki, T Yatabe, T Tamura, K Yamashita, M Yokoyama, J C Ruiz-Rodriguez, B Encina, R Belmonte, I Troncoso, P Tormos, M Riveiro, J Baena, A Sanchez, J Bañeras, J Cordón, N Duran, A Ruiz, J Caballero, X Nuvials, J Riera, J Serra, A M F Rutten, S N M van Ieperen, E P H M Der Kinderen, T Van Logten, L Kovacikova, P Skrak, M Zahorec, U G Kyle, A Akcan-Arikan, J C Silva, G Mackey, J Lusk, M Goldsworthy, L S Shekerdemian, J A Coss-Bu, D Wood, D Harrison, R Parslow, P Davis, J Pappachan, S Goodwin, P Ramnarayan, S Chernyshuk, H Yemets, V Zhovnir, S M Pulitano', S De Rosa, A Mancino, G Villa, F Tosi, P Franchi, G Conti, B Patel, H Khine, A Shah, D Sung, L Singer, S Haghbin, S Inaloo, Z Serati, M Idei, T Nomura, N Yamamoto, Y Sakai, T Yoshida, Y Matsuda, Y Yamaguchi, S Takaki, O Yamaguchi, T Goto, N Longani, S Medar, I R Abdel-Aal, A S El Adawy, H M E H Mohammed, A N Mohamed, S M Parry, L D Knight, L Denehy, N De Morton, C E Baldwin, D Sani, G Kayambu, V Z M da Silva, P Phongpagdi, Z A Puthucheary, C L Granger, J E Rydingsward, C M Horkan, K B Christopher, D McWilliams, C Jones, E Reeves, G Atkins, C Snelson, L M Aitken, J Rattray, J Kenardy, A M Hull, A Ullman, R Le Brocque, M Mitchell, C Davis, B Macfarlane, J C Azevedo, L L Rocha, F F M De Freitas, A M Cavalheiro, N M Lucinio, M S Lobato, G Ebeling, A Kraegpoeth, E Laerkner, I De Brito-Ashurst, C White, S Gregory, L G Forni, E Flowers, A Curtis, C A Wood, K Siu, K Venkatesan, J B H Muhammad, L Ng, E Seet, N Baptista, A Escoval, E Tomas, R Agrawal, R Mathew, A Varma, E Dima, E Charitidou, E Perivolioti, M Pratikaki, C Vrettou, A Giannopoulos, S Zakynthinos, C Routsi, E Atchade, S Houzé, S Jean-Baptiste, G Thabut, C Genève, S Tanaka, B Lortat-Jacob, P Augustin, M Desmard, P Montravers, F J González de Molina, S Barbadillo, R Alejandro, F Álvarez-Lerma, J Vallés, R M Catalán, E Palencia, A Jareño, R M Granada, M L Ignacio, N Cui, D Liu, H Wang, L Su, H Qiu, R Li, K Jaffal, A Rouzé, J Poissy, B Sendid, S Nseir, E Paramythiotou, M Rizos, F Frantzeskaki, A Antoniadou, S Vourli, L Zerva, A Armaganidis, J Riera, J Gottlieb, M Greer, O Wiesner, M Martínez, M Acuña, J Rello, T Welte, E Atchade, T Mignot, S Houzé, S Jean-Baptiste, G Thabut, B Lortat-Jacob, S Tanaka, P Augustin, M Desmard, P Montravers, S Soussi, E Dudoignon, A Ferry, M Chaussard, M Benyamina, A Alanio, S Touratier, M Chaouat, M Lafaurie, M Mimoun, A Mebazaa, M Legrand, M A Sheils, C Patel, L Mohankumar, N Akhtar, S K Pacheco Noriega, N Navarrete Aldana, J L Ávila León, J Durand Baquero, F Fernández Bernal, E Ahmadnia, J S Hadley, M Millar, D Hall, H Hewitt, H Yasuda, M Sanui, T Komuro, S Kawano, K Andoh, H Yamamoto, E Noda, J Hatakeyama, N Saitou, H Okamoto, A Kobayashi, T Takei, S Matsukubo, H B Rotzel, A Serrano Lázaro, D Aguillón Prada, M Rodriguez Gimillo, O Diaz Barinas, M L Blasco Cortes, J Ferreres Franco, J M Segura Roca, A Carratalá, B Gonçalves, R Turon, A Mendes, F Miranda, P J Mata, D Cavalcanti, N Melo, P Lacerda, P Kurtz, C Righy, L E de la Cruz Rosario, S P Gómez Lesmes, J C García Romero, A N García Herrera, E D Díaz Pertuz, M J Gómez Sánchez, E Regidor Sanz, J Barado Hualde, A Ansotegui Hernández, J M Guergué Irazabal, V Spatenkova, O Bradac, P Suchomel, T Urli, E Heusch Lazzeri, R Aspide, M Zanello, L Perez-Borrero, J M Garcia-Alvarez, M D Arias-Verdu, E Aguilar-Alonso, R Rivera-Fernandez, J Mora-Ordoñez, C De La Fuente-Martos, E Castillo-Lorente, F Guerrero-Lopez, S P Gómez Lesmes, L E De la Cruz Rosario, E D Díaz Pertuz, A Ansotegui Hernández, J C García Romero, M J Gómez Sánchez, A N García Herrera, J Roldán Ramírez, E Regidor Sanz, J Barado Hualde, J P Tirapu León, L Navarro-Guillamón, S Cordovilla-Guardia, A Iglesias-Santiago, F Guerrero-López, E Fernández-Mondéjar, A Vidal, M Perez, A Juez, N Arias, L Colino, J L Perez, H Pérez, P Calpe, M A Alcala, D Robaglia, C Perez, S K Lan, M M Cunha, T Moreira, F Santos, E Lafuente, M J Fernandes, J G Silva, L E de la Cruz Rosario, S P Gómez Lesmes, A N García Herrera, J C García Romero, E D Díaz Pertuz, M J Gómez Sánchez, E Regidor Sanz, J G Armando Echeverría, A Ansotegui Hernández, J Barado Hualde, V Podlepich, E Sokolova, E Alexandrova, K Lapteva, P Kurtz, C Shuinotsuka, L Rabello, G Vianna, A Reis, C Cairus, J Salluh, F Bozza, J C Barrios Torres, N J Fernández Araujo, P García-Olivares, E Keough, M Dalorzo, L K Tang, I De Sousa, M Díaz, L J Marcos-Zambrano, J E Guerrero, S E Zamora Gomez, G D Hernandez Lopez, A I Vazquez Cuellar, O R Perez Nieto, J A Castanon Gonzalez, D Bhasin, S Rai, H Singh, O Gupta, M K Bhattal, S Sampley, K Sekhri, R Nandha, F A Aliaga, F Olivares, F Appiani, P Farias, F Alberto, A Hernández, S Pons, R Sonneville, L Bouadma, M Neuville, E Mariotte, A Radjou, J Lebut, S Chemam, G Voiriot, M P Dilly, B Mourvillier, R Dorent, P Nataf, M Wolff, J F Timsit, O Ediboglu, S Ataman, H Ozkarakas, C Kirakli, A Vakalos, V Avramidis, O Obukhova, I A Kurmukov, S Kashiya, E Golovnya, V N Baikova, T Ageeva, T Haritydi, E V Kulaga, J J Rios-Toro, L Perez-Borrero, E Aguilar-Alonso, M D Arias-Verdu, J M Garcia-Alvarez, C Lopez-Caler, C De La Fuente-Martos, S Rodriguez-Fernandez, M Gomez Sanchez-Orézzoli, F Martin-Gallardo, J Nikhilesh, V Joshi, E Villarreal, J Ruiz, M Gordon, A Quinza, J Gimenez, M Piñol, A Castellanos, P Ramirez, Y D Jeon, W Y Jeong, M H Kim, I Y Jeong, M Y Ahn, J Y Ahn, S H Han, J Y Choi, Y G Song, J M Kim, N S Ku, H Shah, F Kellner, F Rezai, N Mistry, P Yodice, V Ovnanian, K Fless, E Handler, R Martínez Alejos, J D Martí Romeu, D González Antón, A Quinart, A Torres Martí, M Llaurado-Serra, A Lobo-Civico, A Ventura-Rosado, A Piñol-Tena, M Pi-Guerrero, C Paños-Espinosa, M Peralvo-Bernat, J Marine-Vidal, R Gonzalez-Engroba, N Montesinos-Cerro, M Treso-Geira, A Valeiras-Valero, L Martinez-Reyes, A Sandiumenge, M F Jimenez-Herrera, S Helyar, P Riozzi, A Noon, G Hallows, H Cotton, J Keep, P A Hopkins, A Taggu, S Renuka, S Sampath, P J T Rood, T Frenzel, R Verhage, M Bonn, P Pickkers, J G van der Hoeven, M van den Boogaard, F Corradi, L Melnyk, F Moggia, R Pienovi, G Adriano, C Brusasco, L Mariotti, M Lattuada, M J Bloomer, M Coombs, K Ranse, R Endacott, B Maertens, K Blot, S Blot, M P van Nieuw Amerongen, E S van der Heiden, J W R Twisk, A R J Girbes, J J Spijkstra, P Riozzi, S Helyar, H Cotton, G Hallows, A Noon, C Bell, K Peters, A Feehan, J Keep, P A Hopkins, K Churchill, K Hawkins, R Brook, N Paver, R Endacott, N Maistry, A van Wijk, N Rouw, T van Galen, S Evelein-Brugman, A Taggu, B Krishna, S Sampath, A Putzu, M Fang, M Boscolo Berto, A Belletti, T Cassina, L Cabrini, M Mistry, Y Alhamdi, I Welters, S T Abrams, C H Toh, H S Han, E M Gil, D S Lee, C M Park, S Winder-Rhodes, R Lotay, J Doyle, M W Ke, W C Huang, C H Chiang, W T Hung, C C Cheng, K C Lin, S C Lin, K R Chiou, S R Wann, C W Shu, P L Kang, G Y Mar, C P Liu, S Dubó, A Aquevedo, M Jibaja, D Berrutti, C Labra, R Lagos, M F García, V Ramirez, M Tobar, F Picoita, C Peláez, D Carpio, L Alegría, C Hidalgo, K Godoy, J Bakker, G Hernández, Y Sadamoto, K Katabami, T Wada, Y Ono, K Maekawa, M Hayakawa, A Sawamura, S Gando, H Marin-Mateos, J L Perez-Vela, R Garcia-Gigorro, M A Corres Peiretti, M J Lopez-Gude, S Chacon-Alves, E Renes-Carreño, J C Montejo-González, K L Parlevliet, H R W Touw, M Beerepoot, C Boer, P W G Elbers, P R Tuinman, S A Abdelmonem, T A Helmy, I El Sayed, S Ghazal, S H Akhlagh, M Masjedi, K Hozhabri, E Kamali, I Zýková, B Paldusová, P Sedlák, D Morman, A M Youn, Y Ohta, M Sakuma, D Bates, T Morimoto, P L Su, W Y Chang, W C Lin, C W Chen, F Facchin, F Zarantonello, G Panciera, A De Cassai, A Venrdramin, A Ballin, T Tonetti, P Persona, C Ori, L Del Sorbo, S Rossi, G Vergani, M Cressoni, D Chiumello, C Chiurazzi, M Brioni, I Algieri, T Tonetti, M Guanziroli, A Colombo, I Tomic, A Colombo, F Crimella, E Carlesso, V Gasparovic, L Gattinoni, A Serpa Neto, M Schmidt, T Pham, A Combes, M Gama de Abreu, P Pelosi, M J Schultz, B H Katira, D Engelberts, R E Giesinger, C Ackerley, T Yoshida, D Zabini, G Otulakowski, M Post, W M Kuebler, P J McNamara, B P Kavanagh, R Pirracchio, M Resche Rigon, M Carone, S Chevret, D Annane, S Eladawy, M El-Hamamsy, N Bazan, M Elgendy, G De Pascale, M S Vallecoccia, S L Cutuli, V Di Gravio, M A Pennisi, G Conti, M Antonelli, D T Andreis, W Khaliq, M Singer, J Hartmann, S Harm, S Alcantara Carmona, P Matia Almudevar, A Naharro Abellán, J Veganzones Ramos, L Pérez Pérez, B Lobo Valbuena, N Martínez Sanz, I Fernández Simón, M Arrigo, E Feliot, N Deye, A Cariou, B Guidet, S Jaber, M Leone, M Resche-Rigon, A Vieillard Baron, M Legrand, E Gayat, A Mebazaa, M Balik, I Kolnikova, M Maly, P Waldauf, G Tavazzi, J Kristof, A Herpain, F Su, E Post, F Taccone, J L Vincent, J Creteur, C Lee, F Hatib, Z Jian, S Buddi, M Cannesson, S Fileković, M Turel, R Knafelj, V Gorjup, R Stanić, P Gradišek, O Cerović, T Mirković, M Noč, J Tirkkonen, H Hellevuo, K T Olkkola, S Hoppu, K C Lin, W T Hung, C C Chiang, W C Huang, W C Juan, S C Lin, C C Cheng, P H Lin, K Y Fong, D S Hou, P L Kang, S R Wann, Y S Chen, G Y Mar, C P Liu, M Paul, W Bougouin, G Geri, F Dumas, B Champigneulle, S Legriel, J Charpentier, J P Mira, C Sandroni, A Cariou, J Zimmerman, E Sullivan, M Noursadeghi, B Fox, D Sampson, L McHugh, T Yager, S Cermelli, T Seldon, S Bhide, R A Brandon, R B Brandon, J Zwaag, R Beunders, P Pickkers, M Kox, F Gul, M K Arslantas, D Genc, N Zibandah, L Topcu, T Akkoc, I Cinel, E Greco, M P Lauretta, D T Andreis, M Singer, I Palacios Garcia, M Cordero, A Diaz Martin, T Aldabó Pallás, J Garnacho Montero, J Revuelto Rey, L Roman Malo, A A Tanaka Montoya, A D C Amador Martinez, L Y Delgado Ayala, E Monares Zepeda, J Franco Granillo, J Aguirre Sanchez, G Camarena Alejo, A Rugerio Cabrera, A Pedraza Montenegro, T Pham, G Beduneau, F Schortgen, L Piquilloud, E Zogheib, M Jonas, F Grelon, I Runge, N Terzi, S Grangé, G Barberet, P G Guitard, J P Frat, A Constan, J M Chrétien, J Mancebo, A Mercat, J C M Richard, L Brochard, E Soilemezi, E Koco, S Savvidou, C Nouris, D Matamis, R Di Mussi, S Spadaro, C A Volta, M Mariani, A Colaprico, C Antonio, F Bruno, S Grasso, A Rodriguez, I Martín-Loeches, E Díaz, J R Masclans, F Gordo, J Solé-Violán, M Bodí, F X Avilés-Jurado, S Trefler, M Magret, L F Reyes, J Marín-Corral, J C Yebenes, A Esteban, A Anzueto, S Aliberti, M I Restrepo, J Skytte Larsson, B Redfors, S E Ricksten, R Haines, J Powell-Tuck, H Leonard, M Ostermann, R E Berthelsen, T S Itenov, A Perner, J U Jensen, M Ibsen, A E K Jensen, M H Bestle, T Bucknall, J Dixon, F Boa, I MacPhee, B J Philips, J Doyle, F Saadat, T Samuels, S Huddart, B McCormick, R DeBrunnar, J Preece, M Swart, C Peden, S Richardson, L Forni, P Kalfon, K Baumstarck, P Estagnasie, M A Geantot, A Berric, G Simon, B Floccard, T Signouret, M Boucekine, M Fromentin, M Nyunga, A Sossou, M Venot, R Robert, A Follin, A Renault, M Garrouste, O Collange, Q Levrat, I Villard, D Thévenin, J Pottecher, R G Patrigeon, N Revel, C Vigne, O Mimoz, P Auquier, S Pawar, T Jacques, K Deshpande, R Pusapati, B Wood, R A Pulham, J Wray, K Brown, C Pierce, S Nadel, P Ramnarayan, J R Azevedo, W S Montenegro, D P Rodrigues, S C Sousa, V F Araujo, A L Leitao, P H Prazeres, A V Mendonca, M P Paula, A Das Neves, C I Loudet, M Busico, D Vazquez, D Villalba, A Lischinsky, M Veronesi, M Emmerich, E Descotte, A Juliarena, M Carboni Bisso, M Grando, A Tapia, M Camargo, D Villani Ulla, L Corzo, H Placido Dos Santos, A Ramos, J A Doglia, E Estenssoro, M Carbonara, S Magnoni, C L Mac Donald, J S Shimony, V Conte, F Triulzi, F Stretti, M Macrì, A Z Snyder, N Stocchetti, D L Brody, V Podlepich, V Shimanskiy, I Savin, K Lapteva, A Chumaev, M C Tjepkema-Cloostermans, J Hofmeijer, A Beishuizen, H Hom, M J Blans, M J A M van Putten, L Longhi, B Frigeni, M Curinga, D Mingone, S Beretta, A Patruno, L Gandini, A Vargiolu, F Ferri, R Ceriani, M R Rottoli, L Lorini, G Citerio, S Pifferi, M Battistini, V Cordolcini, A Agarossi, R Di Rosso, F Ortolano, N Stocchetti, C Mora Lourido, J L Santana Cabrera, J D Martín Santana, L Melián Alzola, C García Del Rosario, H Rodríguez Pérez, R Lorenzo Torrent, S Eslami, A Dalhuisen, T Fiks, M J Schultz, A Abu Hanna, P E Spronk, M Wood, D Maslove, J Muscedere, S H Scott, T Saha, A Hamilton, D Petsikas, D Payne, J G Boyd, Z A Puthucheary, A S McNelly, J Rawal, B Connolly, M J McPhail, P Sidhu, A Rowlerson, J Moxham, S D Harridge, N Hart, H E Montgomery, T Jovaisa, B Thomas, D Gupta, D S Wijayatilake, H P Shum, H S King, K C Chan, K B Tang, W W Yan, C Castro Arias, J Latorre, A Suárez De La Rica, E Maseda Garrido, A Montero Feijoo, C Hernández Gancedo, A López Tofiño, F Gilsanz Rodríguez, L K Gemmell, R Campbell, P Doherty, A MacKay, N Singh, S Vitaller, H Nagib, J Prieto, A Del Arco, B Zayas, C Gomez, S Tirumala, S A Pasha, B K Kumari, P Martinez-Lopez, A Puerto-Morlán, P Nuevo-Ortega, L Martinez Pujol, R Algarte Dolset, B Sánchez González, S Quintana Riera, J Trenado Álvarez, S Quintana, L Martínez, R Algarte, B Sánchez, J Trenado, E Tomas, N Brock, E Viegas, E Filipe, D Cottle, T Traynor, M V Trasmonte Martínez, M Pérez Márquez, L Colino Gómez, N Arias Martínez, J M Milicua Muñoz, B Quesada Bellver, M Muñoz Varea, M Á Alcalá Llorente, C Pérez Calvo, S D Hillier, M C Faulds, H Hendra, N Lawrence, K Maekawa, M Hayakawa, Y Ono, A Kodate, Y Sadamoto, N Tominaga, A Mizugaki, H Murakami, T Yoshida, K Katabami, T Wada, A Sawamura, S Gando, S Silva, L Kerhuel, B Malagurski, G Citerio, R Chabanne, S Laureys, L Puybasset, L Nobile, E R Pognuz, A O Rossetti, F Verginella, N Gaspard, J Creteur, N Ben-Hamouda, M Oddo, F S Taccone, Y Ono, M Hayakawa, H Iijima, K Maekawa, A Kodate, Y Sadamoto, A Mizugaki, H Murakami, K Katabami, T Wada, A Sawamura, S Gando, A Kodate, K Katabami, T Wada, Y Ono, K Maekawa, M Hayakawa, A Sawamura, S Gando, L W Andersen, T Raymond, R Berg, V Nadkarni, A Grossestreuer, T Kurth, M Donnino, A Krüger, P Ostadal, M Janotka, D Vondrakova, N Kongpolprom, J Cholkraisuwat, P T Pekkarinen, G Ristagno, S Masson, R Latini, S Bendel, T Ala-Kokko, T Varpula, J Vaahersalo, S Hoppu, M Tiainen, M M Mion, M Plebani, V Pettilä, M B Skrifvars, Y Son, K S Kim, G J Suh, W Y Kwon, J I Ko, M J Park, F Zama Cavicchi, E Iesu, L Nobile, J L Vincent, J Creteur, F S Taccone, H Tanaka, N Otani, S Ode, S Ishimatsu, L Martínez, R Algarte, B Sánchez, I Romero, F Martínez, S Quintana, J Trenado, D Vondrakova, P Ostadal, A Kruger, M Janotka, F Malek, P Neuzil, Y C Yeh, Y S Chen, C H Wang, C H Huang, A Chao, C T Lee, C H Lai, W S Chan, Y J Cheng, W Z Sun, S Kaese, C Horstmann, P Lebiedz, M Mourad, P Gaudard, J Eliet, N Zeroual, P Colson, P Ostadal, M Mlcek, M Hrachovina, A Kruger, D Vondrakova, M Janotka, M Mates, P Hala, O Kittnar, P Neuzil, A Jacky, A Rudiger, D R Spahn, D A Bettex, A Kara, S Akin, D Dos Reis Miranda, A Struijs, K Caliskan, R J van Thiel, E A Dubois, W de Wilde, F Zijlstra, D Gommers, C Ince, L Marca, A Xini, W Mongkolpun, C P R Cordeiro, R T Leite, O Lheureux, A Bader, L Rincon, C Santacruz, J C Preiser, A Chao, A S Chao, Y S Chen, W Kim, C Ahn, Y Cho, T H Lim, J Oh, K S Choi, B H Jang, J K Ha, A Mecklenburg, J Stamm, G Soeffker, M Kubik, K Sydow, H Reichenspurner, S Kluge, S Braune, B Bergantino, F Ruberto, E Magnanimi, E Privato, V Zullino, K Bruno, F Pugliese, G Sales, V Girotto, F Vittone, L Brazzi, C Fritz, A Kimmoun, F Vanhuyse, B Trifan, S Orlowski, E Albuisson, N Tran, B Levy, V Chhor, J Joachim, A Follin, B Champigneulle, J Chatelon, G Fave, J Mantz, R Pirracchio, D Díaz Diaz, M Villanova, M Aguirregabyria, G Andrade, L López, E Palencia, G John, R Cowan, R Hart, K Lake, K Litchfield, J W Song, Y J Lee, Y J Cho, S Choi, P Vermeir, D Vandijck, S Blot, A Mariman, R Verhaeghe, M Deveugele, D Vogelaers, L Chok, E B Bachli, D Bettex, S R Cottini, E Keller, M Maggiorini, R Schuepbach, T Fiks, C Stiphout, M Grevelink, I Vaneker, A Ruijter, M Buise, P E Spronk, S 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September 2016: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/27642026/drivers-of-maternity-care-in-high-income-countries-can-health-systems-support-woman-centred-care
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REVIEW
Dorothy Shaw, Jeanne-Marie Guise, Neel Shah, Kristina Gemzell-Danielsson, K S Joseph, Barbara Levy, Fontayne Wong, Susannah Woodd, Elliott K Main
In high-income countries, medical interventions to address the known risks associated with pregnancy and birth have been largely successful and have resulted in very low levels of maternal and neonatal mortality. In this Series paper, we present the main care delivery models, with case studies of the USA and Sweden, and examine the main drivers of these models. Although nearly all births are attended by a skilled birth attendant and are in an institution, practice, cadre, facility size, and place of birth vary widely; for example, births occur in homes, birth centres, midwifery-led birthing units in hospitals, and in high intervention hospital birthing facilities...
November 5, 2016: Lancet
https://www.readbyqxmd.com/read/27591181/gotmeds-development-and-evaluation-of-an-interactive-module-for-trainees-on-reducing-patient-s-drug-costs
#7
Rupali Kumar, Jeanne M Farnan, Neel T Shah, Andrew Levy, Mark Saathoff, Vineet M Arora
No abstract text is available yet for this article.
December 2016: American Journal of Medicine
https://www.readbyqxmd.com/read/27367550/patient-and-physician-attitudes-toward-low-value-diagnostic-tests
#8
A Sofia Warner, Neel Shah, Abraham Morse, Eliyahu Y Lehmann, Rie Maurer, Zoe Moyer, Lisa Soleymani Lehmann
No abstract text is available yet for this article.
August 1, 2016: JAMA Internal Medicine
https://www.readbyqxmd.com/read/27282513/peptide-inhibitor-of-complement-c1-modulates-acute-intravascular-hemolysis-of-mismatched-red-blood-cells-in-rats
#9
Parvathi S Kumar, Haree K Pallera, Pamela S Hair, Magdielis Gregory Rivera, Tushar A Shah, Alice L Werner, Frank A Lattanzio, Kenji M Cunnion, Neel K Krishna
BACKGROUND: Acute hemolytic transfusion reactions have a broad clinical presentation from mild and transitory signs and symptoms to shock, disseminated intravascular coagulation, renal failure, and death. We have recently developed a rat model of acute intravascular hemolysis showing that the classical complement pathway mediates antibody-dependent hemolysis. The objective of this study was to evaluate the role of the classical pathway inhibitor peptide inhibitor of complement C1 (PIC1) in this animal model...
August 2016: Transfusion
https://www.readbyqxmd.com/read/27037091/relationship-between-pain-relief-reduction-in-pain-associated-sleep-interference-and-overall-impression-of-improvement-in-patients-with-postherpetic-neuralgia-treated-with-extended-release-gabapentin
#10
RANDOMIZED CONTROLLED TRIAL
Neel Mehta, Iwona Bucior, Shay Bujanover, Rajiv Shah, Amitabh Gulati
BACKGROUND: Postherpetic neuralgia (PHN) interferes with patients' quality of life, and disturbed sleep is a prevalent complaint. Pain-associated sleep interference in turn enhances pain and/or reduces pain tolerance. Therefore, reducing sleep interference by pain, in addition to pain control, may improve patient care. To address this notion, we characterized relationships among changes in pain intensity, sleep interference, and overall impression of improvement in PHN patients treated with gastroretentive gabapentin (G-GR)...
April 1, 2016: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/27017558/eosinophil-quantitated-urine-kinetic-a-novel-assay-for-assessment-of-eosinophilic-esophagitis
#11
Kenji M Cunnion, Lauren K Willis, Heather B Minto, Tanya C Burch, Alice L Werner, Tushar A Shah, Neel K Krishna, Julius O Nyalwidhe, Kelly M Maples
BACKGROUND: Eosinophilic esophagitis (EoE) is a chronic disease that requires long-term medical management and monitoring. The eosinophil count determined during esophageal biopsy remains the gold standard for diagnosis and monitoring of EoE. Although markers of eosinophil degranulation correlate with symptoms, eosinophil counts do not correlate. Development of a noninvasive, cost-effective biomarker of eosinophil activation for the evaluation of EoE is an unmet medical need. OBJECTIVE: To conduct a proof-of-concept study to evaluate the potential for measuring urinary 3-bromotyrosine (3-BT) levels in creatinine normalized urine for quantifying eosinophil degranulation in EoE disease...
May 2016: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/27001102/interview-with-neel-shah-md-mpp
#12
Khin-Kyemon Aung
No abstract text is available yet for this article.
March 2016: Healthcare
https://www.readbyqxmd.com/read/26876345/nurses-count-tracking-performance-to-improve-cesarean-delivery-rates
#13
Joyce K Edmonds, Michele R Hacker, Toni H Golen, Neel T Shah
No abstract text is available yet for this article.
March 2016: Birth
https://www.readbyqxmd.com/read/26854538/design-of-a-split-intein-with-exceptional-protein-splicing-activity
#14
Adam J Stevens, Zachary Z Brown, Neel H Shah, Giridhar Sekar, David Cowburn, Tom W Muir
Protein trans-splicing (PTS) by split inteins has found widespread use in chemical biology and biotechnology. Herein, we describe the use of a consensus design approach to engineer a split intein with enhanced stability and activity that make it more robust than any known PTS system. Using batch mutagenesis, we first conduct a detailed analysis of the difference in splicing rates between the Npu (fast) and Ssp (slow) split inteins of the DnaE family and find that most impactful residues lie on the second shell of the protein, directly adjacent to the active site...
February 24, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/26642048/complement-effectors-of-inflammation-in-cystic-fibrosis-lung-fluid-correlate-with-clinical-measures-of-disease
#15
COMPARATIVE STUDY
Laura A Sass, Pamela S Hair, Amy M Perkins, Tushar A Shah, Neel K Krishna, Kenji M Cunnion
In cystic fibrosis (CF), lung damage is mediated by a cycle of obstruction, infection, and inflammation. Here we explored complement inflammatory effectors in CF lung fluid. In this study soluble fractions (sols) from sputum samples of 15 CF patients were assayed for complement effectors and analyzed with clinical measurements. The pro-inflammatory peptide C5a was increased 4.8-fold (P = 0.04) in CF sols compared with controls. Incubation of CF sols with P. aeruginosa or S. aureus increased C5a concentration 2...
2015: PloS One
https://www.readbyqxmd.com/read/26624825/relationship-between-cesarean-delivery-rate-and-maternal-and-neonatal-mortality
#16
George Molina, Thomas G Weiser, Stuart R Lipsitz, Micaela M Esquivel, Tarsicio Uribe-Leitz, Tej Azad, Neel Shah, Katherine Semrau, William R Berry, Atul A Gawande, Alex B Haynes
IMPORTANCE: Based on older analyses, the World Health Organization (WHO) recommends that cesarean delivery rates should not exceed 10 to 15 per 100 live births to optimize maternal and neonatal outcomes. OBJECTIVES: To estimate the contemporary relationship between national levels of cesarean delivery and maternal and neonatal mortality. DESIGN, SETTING, AND PARTICIPANTS: Cross-sectional, ecological study estimating annual cesarean delivery rates from data collected during 2005 to 2012 for all 194 WHO member states...
December 1, 2015: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/26615964/balancing-spatially-regulated-%C3%AE-actin-translation-and-dynamin-mediated-endocytosis-is-required-to-assemble-functional-epithelial-monolayers
#17
Lissette A Cruz, Pavan Vedula, Natasha Gutierrez, Neel Shah, Steven Rodriguez, Brian Ayee, Justin Davis, Alexis J Rodriguez
Regulating adherens junction complex assembly/disassembly is critical to maintaining epithelial homeostasis in healthy epithelial tissues. Consequently, adherens junction structure and function is often perturbed in clinically advanced tumors of epithelial origin. Some of the most studied factors driving adherens junction complex perturbation in epithelial cancers are transcriptional and epigenetic down-regulation of E-cadherin expression. However, numerous reports demonstrate that post-translational regulatory mechanisms such as endocytosis also regulate early phases of epithelial-mesenchymal transition and metastatic progression...
December 2015: Cytoskeleton
https://www.readbyqxmd.com/read/26595246/the-challenge-of-understanding-health-care-costs-and-charges
#18
Vineet Arora, Christopher Moriates, Neel Shah
No abstract text is available yet for this article.
November 2015: AMA Journal of Ethics
https://www.readbyqxmd.com/read/26567111/tumor-associated-endo180-requires-stromal-derived-lox-to-promote-metastatic-prostate-cancer-cell-migration-on-human-ecm-surfaces
#19
Matthew P Caley, Helen King, Neel Shah, Kai Wang, Mercedes Rodriguez-Teja, Julian H Gronau, Jonathan Waxman, Justin Sturge
The diverse composition and structure of extracellular matrix (ECM) interfaces encountered by tumor cells at secondary tissue sites can influence metastatic progression. Extensive in vitro and in vivo data has confirmed that metastasizing tumor cells can adopt different migratory modes in response to their microenvironment. Here we present a model that uses human stromal cell-derived matrices to demonstrate that plasticity in tumor cell movement is controlled by the tumor-associated collagen receptor Endo180 (CD280, CLEC13E, KIAA0709, MRC2, TEM9, uPARAP) and the crosslinking of collagen fibers by stromal-derived lysyl oxidase (LOX)...
February 2016: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/26504371/mixed-brownian-alignment-and-n%C3%A3-el-rotations-in-superparamagnetic-iron-oxide-nanoparticle-suspensions-driven-by-an-ac-field
#20
Saqlain A Shah, Daniel B Reeves, R Matthew Ferguson, John B Weaver, Kannan M Krishnan
Superparamagnetic iron oxide nanoparticles with highly nonlinear magnetic behavior are attractive for biomedical applications like magnetic particle imaging and magnetic fluid hyperthermia. Such particles display interesting magnetic properties in alternating magnetic fields and here we document experiments that show differences between the magnetization dynamics of certain particles in frozen and melted states. This effect goes beyond the small temperature difference (ΔT ~ 20 °C) and we show the dynamics to be a mixture of Brownian alignment of the particles and Néel rotation of their moments occurring in liquid particle suspensions...
2015: Physical Review. B, Condensed Matter and Materials Physics
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