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Neel Shah

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https://www.readbyqxmd.com/read/29661024/surface-engineered-lipid-nanoparticle-mediated-site-specific-drug-delivery-system-for-the-treatment-of-inflammatory-bowel-disease
#1
Gurpreet Kaur Sinhmar, Neel N Shah, Shruti U Rawal, Nimitt V Chokshi, Hiren N Khatri, Bhoomika M Patel, Mayur M Patel
The major challenge for the treatment of inflammatory bowel disease (IBD) is the incompetence to deliver the drug molecule selectively at the site of inflammation. Taking this into consideration, we proposed development of mannosylated nanostructured lipid carrier system (Mn-NLCs) for active targeting and site-specific delivery of budesonide to the inflamed tissues. The developed Mn-NLCs were characterized for particle size and size distribution, zeta potential, %entrapment efficiency, FTIR and TEM analysis...
April 16, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29571276/estimating-the-clinical-effectiveness-and-value-based-price-range-of-erenumab-for-the-prevention-of-migraine-in-patients-with-prior-treatment-failures-a-us-societal-perspective
#2
Richard B Lipton, Alan Brennan, Stephen Palmer, Anthony J Hatswell, Joshua K Porter, Sandhya Sapra, Guillermo Villa, Neel Shah, Stewart Tepper, David Dodick
BACKGROUND: Frequent migraine with four or more headache days per month is a common, disabling neurovascular disease. From a US societal perspective, this analysis models the clinical efficacy and estimates the value-based price (VBP) for erenumab, a fully human monoclonal antibody that inhibits the calcitonin gene-related peptide receptor. METHODS: A Markov health state transition model was developed to estimate the incremental costs, quality-adjusted life-years (QALYs), and value-based price range for erenumab in migraine prevention...
April 3, 2018: Journal of Medical Economics
https://www.readbyqxmd.com/read/29561353/thirty-day-readmissions-after-upper-and-lower-gastrointestinal-hemorrhage-a-national-perspective-in-the-united-states
#3
Smit D Patel, Rupak Desai, Upenkumar Patel, Sandeep Singh, Zinal Patel, Neel Patel, Allan Zhang, Amruta H Panwala, Vinshi N Khan, Gagandeep Singh, Nihar Shah
BACKGROUND: Upper gastrointestinal hemorrhage (UGIH) and lower gastrointestinal hemorrhage (LGIH) are 2 of the most common reasons for hospital admissions across the United States. The 30-day readmission after index admission poses a major burden on the health care infrastructure, and thus, it is important to assess the causes of 30-day readmission for patients with UGIH and LGIH. METHODS: The study cohort was derived from the 2013 National Readmission Database...
March 20, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29547119/fine-tuning-of-substrate-preferences-of-the-src-family-kinase-lck-revealed-through-a-high-throughput-specificity-screen
#4
Neel H Shah, Mark Löbel, Arthur Weiss, John Kuriyan
The specificity of tyrosine kinases is predominantly attributed to localization effects dictated by non-catalytic domains. We developed a method to profile the specificities of tyrosine kinases by combining bacterial surface-display of peptide libraries with next-generation sequencing. Using this, we showed that the tyrosine kinase ZAP-70, which is critical for T cell signaling, discriminates substrates through an electrostatic selection mechanism encoded within its catalytic domain (Shah et al. 2016). Here, we expand this high-throughput platform to analyze the intrinsic specificity of any tyrosine kinase domain against thousands of peptides derived from human tyrosine phosphorylation sites...
March 16, 2018: ELife
https://www.readbyqxmd.com/read/29522087/eroding-access-and-quality-of-childbirth-care-in-rural-us-counties
#5
Neel T Shah
No abstract text is available yet for this article.
March 8, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29476560/common-challenges-managing-bed-and-staff-availability-on-labor-and-delivery-units-in-the-united-states-a-qualitative-analysis
#6
Avery Plough, Natalie Henrich, Grace Galvin, Neel T Shah
BACKGROUND: Managers of labor and delivery units need to ensure that their limited supply of beds and nursing staff are adequately available, despite uncertainty with respect to patient needs. The ability to address this challenge has been associated with patient outcomes; however, best practices have not been defined. METHODS: We conducted a secondary analysis of 96 interviews with nurse and physician managers from 48 labor and delivery units across the United States...
February 24, 2018: Birth
https://www.readbyqxmd.com/read/29446063/direct-and-indirect-healthcare-resource-utilization-and-costs-among-migraine-patients-in-the-united-states
#7
Machaon Bonafede, Sandhya Sapra, Neel Shah, Stewart Tepper, Katherine Cappell, Pooja Desai
OBJECTIVE: The goal of this analysis was to provide a contemporary estimate of the burden of migraine, incorporating both direct and indirect costs, by comparing the costs of migraine patients to a matched group of patients without migraine in a large, nationally representative sample of commercially insured patients in the United States. BACKGROUND: Previous studies have shown that the economic burden of migraine in the United States is substantial for payers, patients, and employers...
February 15, 2018: Headache
https://www.readbyqxmd.com/read/29420404/association-between-labor-and-delivery-unit-census-and-delays-in-patient-management-findings-from-a-computer-simulation-module
#8
Rose L Molina, Matthew Gombolay, Jennifer Jonas, Anna M Modest, Julie Shah, Toni H Golen, Neel T Shah
OBJECTIVE: To demonstrate the association between increases in labor and delivery unit census and delays in patient care decisions using a computer simulation module. METHODS: This was an observational cohort study of labor and delivery unit nurse managers. We developed a computer module that simulates the physical layout and clinical activity of the labor and delivery unit at our tertiary care academic medical center, in which players act as clinical managers in dynamically allocating nursing staff and beds as patients arrive, progress in labor, and undergo procedures...
March 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29376433/process-optimization-and-characterization-of-budesonide-loaded-nanostructured-lipid-carriers-for-the-treatment-of-inflammatory-bowel-disease
#9
Gurpreet Kaur Sinhmar, Neel N Shah, Nimitt V Chokshi, Hiren N Khatri, Mayur M Patel
The major challenge involved in the treatment of inflammatory bowel disease is targeted delivery of the drug at the site of inflammation. As nanoparticles possess the ability to accumulate at the site of inflammation, present investigation aims at development of Budesonide-loaded nanostructured lipid carrier systems (BDS-NLCs) for the treatment of inflammatory bowel disease. BDS-NLCs were prepared by employing a high pressure homogenization technique. Various preliminary trials were performed for optimization of the NLCs in which different processes, as well as formulation parameters, were studied...
February 6, 2018: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29343837/neurocognitive-dysfunction-in-hematopoietic-cell-transplant-recipients-expert-review-from-the-late-effects-and-quality-of-life-working-committee-of-the-cibmtr-and-complications-and-quality-of-life-working-party-of-the-ebmt
#10
REVIEW
David Buchbinder, Debra Lynch Kelly, Rafael F Duarte, Jeffery J Auletta, Neel Bhatt, Michael Byrne, Zachariah DeFilipp, Melissa Gabriel, Anuj Mahindra, Maxim Norkin, Helene Schoemans, Ami J Shah, Ibrahim Ahmed, Yoshiko Atsuta, Grzegorz W Basak, Sara Beattie, Sita Bhella, Christopher Bredeson, Nancy Bunin, Jignesh Dalal, Andrew Daly, James Gajewski, Robert Peter Gale, John Galvin, Mehdi Hamadani, Robert J Hayashi, Kehinde Adekola, Jason Law, Catherine J Lee, Jane Liesveld, Adriana K Malone, Arnon Nagler, Seema Naik, Taiga Nishihori, Susan K Parsons, Angela Scherwath, Hannah-Lise Schofield, Robert Soiffer, Jeff Szer, Ida Twist, Anne B Warwick, Baldeep M Wirk, Jean Yi, Minoo Battiwalla, Mary D E Flowers, Bipin Savani, Bronwen E Shaw
Hematopoietic cell transplantation (HCT) is a potentially curative treatment for children and adults with malignant and non-malignant diseases. Despite increasing survival rates, long-term morbidity following HCT is substantial. Neurocognitive dysfunction is a serious cause of morbidity, yet little is known about neurocognitive dysfunction following HCT. To address this gap, collaborative efforts of the Center for International Blood and Marrow Transplant Research and the European Society for Blood and Marrow Transplantation undertook an expert review of neurocognitive dysfunction following HCT...
January 17, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29340561/generic-substitution-rates-of-oral-contraceptives-and-associated-out-of-pocket-cost-savings-between-january-2010-and-december-2014
#11
Mark Chee, James X Zhang, Samantha Ngooi, Christopher Moriates, Neel Shah, Vineet M Arora
No abstract text is available yet for this article.
April 1, 2018: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29338994/both-patients-and-maternity-care-providers-can-benefit-from-payment-reform-four-steps-to-prepare
#12
Malini A Nijagal, Neel T Shah, Jeff Levin-Scherz
Many Medicaid programs and private health plans are implementing new models of maternity care reimbursement, and clinicians face mounting pressure to demonstrate high-quality care at a lower cost. Clinicians will be better prepared to meet these challenges with a fuller understanding of new payment models and the opportunities they present. We describe the structure of maternity care episode payments and recommend 4 ways that clinicians can prepare for success as value-based payment models are implemented: identify opportunities to improve outcomes and experience, measure quality, reduce waste, and work in teams across settings...
April 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29315449/trends-and-epidemiology-of-tennis-related-sprains-strains-in-the-united-states-2010-to-2016
#13
Jonathan D Chevinsky, Jared M Newman, Neil V Shah, Neel Pancholi, John Holliman, Nipun Sodhi, Ahmed Eldib, Qais Naziri, Bashir A Zikria, John P Reilly, Scott E Barbash, William P Urban
BACKGROUND: While tennis is one of the most popular sports in the world, it predisposes those who play it to a number of injuries. Several studies have shown sprains/strains to be the most common tennis-related injury. However, data is limited regarding trends in tennis-related sprains/strains. Therefore, this study evaluated: 1) trends in tennis-related sprains/strains; 2) trends in tennis-related sprains/strains by age; and 3) trends in the most common tennis-related sprained/strained body parts...
December 22, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/29237129/zap-70-in-signaling-biology-and-disease
#14
Byron B Au-Yeung, Neel H Shah, Lin Shen, Arthur Weiss
T cells possess an array of functional capabilities important for host defense against pathogens and tumors. T cell effector functions require the T cell antigen receptor (TCR). The TCR has no intrinsic enzymatic activity, and thus signal transduction from the receptor relies on additional signaling molecules. One such molecule is the cytoplasmic tyrosine kinase ZAP-70, which associates with the TCR complex and is required for initiating the canonical biochemical signal pathways downstream of the TCR. In this article, we describe recent structure-based insights into the regulation and substrate specificity of ZAP-70, and then we review novel methods for determining the role of ZAP-70 catalytic activity-dependent and -independent signals in developing and mature T cells...
December 13, 2017: Annual Review of Immunology
https://www.readbyqxmd.com/read/29221840/a-multicenter-study-of-irrigation-and-debridement-in-total-knee-arthroplasty-periprosthetic-joint-infection-treatment-failure-is-high
#15
Kenneth L Urish, Andrew G Bullock, Alexander M Kreger, Neel B Shah, Kwonho Jeong, Scott D Rothenberger
BACKGROUND: In total knee arthroplasty (TKA) periprosthetic joint infection (PJI), irrigation and debridement (I&D) with component retention is a treatment option with a wide variation in reported failure rates. The purpose of this study was to determine failure rates, outcomes, and factors that predict failure in I&D for TKA PJI. METHODS: A multicenter observational study of patients with a TKA PJI and subsequently undergoing an I&D with retention of components was conducted...
April 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29211338/look-then-leap-quality-and-improving-maternity-care
#16
N T Shah
No abstract text is available yet for this article.
December 6, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29181359/articular-reconstruction-using-subchondral-cementation-and-threaded-kirschner-wires-in-giant-cell-tumor-a-novel-technique
#17
Padmanabh H Vora, Rameez Musa, Neel M Bhavsar, Darshan Shah
Introduction: Giant Cell Tumor(GCT) is one of an infrequently encountered tumor by orthopaedic surgeons in clinical practice. It is described as 'locally malignant' tumor found in epimetaphyseal region of long bones, peculiarly around knee. We present a case of a solitary, benign Campanacci Grade 2 GCT in right lateral femoral condyle in 38 year old female and our treatment. Case Report: A 38 year old female presented to our outpatient department with chief complaint of constant, moderate pain in right knee increasing in duration since 3 months...
July 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29112747/what-we-know-about-tuberculosis-transmission-an-overview
#18
REVIEW
Gavin Churchyard, Peter Kim, N Sarita Shah, Roxana Rustomjee, Neel Gandhi, Barun Mathema, David Dowdy, Anne Kasmar, Vicky Cardenas
Tuberculosis remains a global health problem with an enormous burden of disease, estimated at 10.4 million new cases in 2015. To stop the tuberculosis epidemic, it is critical that we interrupt tuberculosis transmission. Further, the interventions required to interrupt tuberculosis transmission must be targeted to high-risk groups and settings. A simple cascade for tuberculosis transmission has been proposed in which (1) a source case of tuberculosis (2) generates infectious particles (3) that survive in the air and (4) are inhaled by a susceptible individual (5) who may become infected and (6) then has the potential to develop tuberculosis...
November 3, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29112744/research-roadmap-for-tuberculosis-transmission-science-where-do-we-go-from-here-and-how-will-we-know-when-we-re-there
#19
REVIEW
Sara C Auld, Anne G Kasmar, David W Dowdy, Barun Mathema, Neel R Gandhi, Gavin J Churchyard, Roxana Rustomjee, N Sarita Shah
High rates of tuberculosis transmission are driving the ongoing global tuberculosis epidemic, and there is a pressing need for research focused on understanding and, ultimately, halting transmission. The ongoing tuberculosis-human immunodeficiency virus (HIV) coepidemic and rising rates of drug-resistant tuberculosis in parts of the world add further urgency to this work. Success in this research will require a concerted, multidisciplinary effort on the part of tuberculosis scientists, clinicians, programs, and funders and must span the research spectrum from biomedical sciences to the social sciences, public health, epidemiology, cost-effectiveness analyses, and operations research...
November 3, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29083975/factors-associated-with-direct-health-care-costs-among-patients-with-migraine
#20
Machaon Bonafede, Qian Cai, Katherine Cappell, Gilwan Kim, Sandhya J Sapra, Neel Shah, Katherine Widnell, Paul Winner, Pooja Desai
BACKGROUND: Migraine imposes substantial economic burden on patients and the health care system. Approximately 18% of women and 6% of men suffer from migraine in the United States. This is a heterogeneous group, and little data are available to evaluate factors associated with migraine costs. OBJECTIVE: To evaluate characteristics associated with high costs among commercially insured patients with migraine. METHODS: This retrospective analysis identified patients with migraine in the Truven Health MarketScan Research Databases between January 2008 and June 2013...
November 2017: Journal of Managed Care & Specialty Pharmacy
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