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https://www.readbyqxmd.com/read/28524604/prevalence-of-high-fractional-exhaled-nitric-oxide-among-us-youth-with-asthma
#1
Duong T Nguyen, Brian K Kit, Debra Brody, Lara J Akinbami
BACKGROUND: High fractional exhaled nitric oxide (FeNO) is an indicator of poor asthma control and has been proposed as a non-invasive assessment tool to guide asthma management. OBJECTIVE: We aimed to describe the prevalence of and factors associated with high FeNO among US youth with asthma. METHODS: Data from 716 children and adolescents with asthma ages 6-19 years who participated in the 2007-2012 National Health and Nutrition Examination Survey were analyzed...
June 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28520323/-asthma-and-obesity
#2
REVIEW
R Trokart, S Demarche, F Schleich, N Paquot, R Louis
Asthma and obesity are both common diseases in western world. According to the data from our asthma clinic 20 % of our patients are obese and this rate increases up to 25 % in severe asthmatics included in the Belgian Severe Asthma national Registry. Alteration of thoracic mechanics contributes to greater symptom burden and poor asthma control in obese asthmatics. In particular the response to inhaled corticoids is attenuated. Weight loss results in a dramatic improvement in asthma control and should be a major goal in the asthma management of these patients...
May 2017: Revue Médicale de Liège
https://www.readbyqxmd.com/read/28515402/differences-in-fraction-of-exhaled-nitric-oxide-values-measured-by-two-hand-helded-analyzers-nobreath-%C3%A2-and-niox-vero-%C3%A2
#3
Takahiro Tsuburai, Yousuke Kamide, Yuto Nakamura, Yasuhiro Tomita, Yuto Hamada, Kentaro Watai, Hiroaki Hayashi, Kiyoshi Sekiya, Chihiro Mitsui, Yuma Fukutomi, Akio Mori, Masami Taniguchi
BACKGROUND: The fraction of exhaled nitric oxide (FENO) is a useful marker of asthma control. The FENO measurement with two hand-helded analyzers (NObreath(®) and NIOX Vero(®)) may be more affordable, no studies have examined the differences in FENO values measured with those methods in adult. METHODS: The study population comprised 44 subjects at our outpatient clinic. FeNO values (FENOb and FENOv) were measured by two methods (NObreath(®) and NIOX Vero(®))...
2017: Arerugī, [Allergy]
https://www.readbyqxmd.com/read/28514613/kit-inhibition-by-imatinib-in-patients-with-severe-refractory-asthma
#4
Katherine N Cahill, Howard R Katz, Jing Cui, Juying Lai, Shamsah Kazani, Allison Crosby-Thompson, Denise Garofalo, Mario Castro, Nizar Jarjour, Emily DiMango, Serpil Erzurum, Jennifer L Trevor, Kartik Shenoy, Vernon M Chinchilli, Michael E Wechsler, Tanya M Laidlaw, Joshua A Boyce, Elliot Israel
BACKGROUND: Mast cells are present in the airways of patients who have severe asthma despite glucocorticoid treatment; these cells are associated with disease characteristics including poor quality of life and inadequate asthma control. Stem cell factor and its receptor, KIT, are central to mast-cell homeostasis. We conducted a proof-of-principle trial to evaluate the effect of imatinib, a KIT inhibitor, on airway hyperresponsiveness, a physiological marker of severe asthma, as well as on airway mast-cell numbers and activation in patients with severe asthma...
May 18, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28513250/combined-measurements-of-fractional-exhaled-nitric-oxide-and-nasal-nitric-oxide-levels-for-assessing-upper-airway-diseases-in-asthmatic-patients
#5
Takamitsu Asano, Masaya Takemura, Yoshihiro Kanemitsu, Makoto Yokota, Kensuke Fukumitsu, Norihisa Takeda, Hiroya Ichikawa, Hisatoshi Hijikata, Takehiro Uemura, Osamu Takakuwa, Hirotsugu Ohkubo, Ken Maeno, Yutaka Ito, Tetsuya Oguri, Atsushi Nakamura, Yumi Maki, Yoshihisa Nakamura, Motohiko Suzuki, Akio Niimi
BACKGROUND: Despite the close linkage between rhinitis, chronic rhinosinusitis (CRS) and asthma, relevant biomarkers of both upper and lower airway inflammation are rare. METHODS: Patients with asthma (without upper airway disease [UAD; n = 24], with rhinitis [n = 25], CRS [n = 24], and nasal polyps [n = 2]), isolated rhinitis (n = 13), isolated CRS (n = 13), and 10 healthy controls were prospectively recruited. Fractional exhaled nitric oxide (NO) levels at 50 mL/s (FeNO50), nasal NO levels, Lund-Macay-scores of sinus computed-tomography and an asthma control questionnaire (ACQ) were evaluated...
May 17, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28507765/asthma-epidemiology-of-disease-control-in-latin-america-short-review
#6
REVIEW
Dirceu Solé, Carolina Sanchez Aranda, Gustavo Falbo Wandalsen
Asthma is reported as one of the most common chronic diseases in childhood, impairing the quality of life of patients and their families and incurring high costs to the healthcare system and society. Despite the development of new drugs and the availability of international treatment guidelines, asthma is still poorly controlled, especially in Latin America. Original and review articles on asthma control or epidemiology with high levels of evidence have been selected for analysis among those published in PubMed referenced journals during the last 20 years, using the following keywords: "asthma control" combined with "Latin America", " epidemiology", "prevalence", "burden", "mortality", "treatment and unmet needs", "children", "adolescents", and "infants"...
2017: Asthma research and practice
https://www.readbyqxmd.com/read/28503097/asthma-management-among-allergists-in-italy-results-from-a-survey
#7
M S Magnoni, M Caminati, G W Canonica, F Arpinelli, A Rizzi, G Senna
BACKGROUND: In Europe more than 50% of asthmatic treated patients have not well-controlled asthma. Asthma affects about 2.5 million of patients in Italy. AIMS AND OBJECTIVES: The present survey aims at investigating how Italian allergists approach asthmatic patients, in order to highlight pitfalls and unmet needs concerning real-life asthma management. METHODS: An anonymous 16 item web questionnaire was available (April-October 2015) to all allergists who visited the web site of SIAAIC (Società Italiana di Allergologia, Asma Immunologia Clinica)...
2017: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/28502418/a-multicenter-cross-sectional-observational-study-of-budesonide-formoterol-maintenance-and-reliever-therapy-in-real-world-settings
#8
Jiangtao Lin, Jing Li, Wencheng Yu, Yuejian Liu, Chuntao Liu, Ping Chen, Huijie He, Bei He, Shuang Liu, Xiangdong Zhou
BACKGROUND: To assess the level of asthma control achieved with budesonide/formoterol in Chinese patients with asthma, based on the Global Initiative for Asthma (GINA) definition and Asthma Control Test (ACT) score. METHODS: This multicenter, cross-sectional study (NCT01785901) evaluated asthma control levels in Chinese patients receiving physician-prescribed budesonide/formoterol treatment. Adults with a diagnosis of asthma ≥6 months and receiving budesonide/formoterol treatment ≥3 months before screening were consecutively enrolled...
June 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28497926/plasma-lte4-pgf2%C3%AE-ratio-and-blood-eosinophil-count-are-increased-in-elderly-asthmatics-with-previous-asthma-exacerbation
#9
Ga Young Ban, Young Min Ye, Sang Ha Kim, Gyu Young Hur, Joo Hee Kim, Jae Jung Shim, Kumsun Cho, Joo Youn Cho, Hae Sim Park
The tools for asthma control assessment recommended by the current guideline are cognitive function- and effort-dependent, which is substantially impaired in the elderly. The aim of this study is to investigate objective assessment tools of asthma control status and previous asthma exacerbation (AE) in elderly subjects. Asthmatics aged >60 years who were treated with step 2 or 3 by the Global Initiative for Asthma (GINA) guideline were enrolled. During the 12-week study period, the subjects used either 400 μg of budesonide plus 10 mg of montelukast or 800 μg of inhaled budesonide...
July 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28494181/characterization-of-asthma-chronic-obstructive-pulmonary-disease-overlap-syndrome-a-qualitative-analysis
#10
Claudie Rodrigue, Marie-France Beauchesne, Valérie Mallette, Catherine Lemière, Pierre Larivée, Lucie Blais
Approximately 15-20% of patients with chronic obstructive pulmonary disease (COPD) also display characteristics of asthma. In May 2014, the asthma-COPD overlap syndrome (ACOS) was briefly addressed in the Global Initiative for Asthma (GINA) and Global Initiative for Chronic Obstructive Lung Disease (GOLD) strategy documents. We evaluated how pulmonologists diagnose and treat ACOS and how they assess its control. Pulmonologists from two university healthcare centers, having ≥ 1 year experience, treating patients with asthma, COPD, or ACOS, were invited to participate in focus groups...
May 11, 2017: COPD
https://www.readbyqxmd.com/read/28489959/mood-disorders-in-adult-asthma-phenotypes
#11
Marina Labor, Slavica Labor, Iva Jurić, Vladimir Fijačko, Sanja Popović Grle, Davor Plavec
OBJECTIVE: Studies show high comorbidity of mood disorders in asthma. As asthma is a highly heterogeneous disease with different phenotypes it can be expected that there is a difference in this association with different asthma phenotypes. The aim of our cross-sectional study was to assess the association of specific asthma phenotypes with anxiety and/or depression and their impact on asthma control. METHODS: A cross-sectional study in 201 consecutive adult outpatients with asthma (≥18 years of age) was conducted...
May 10, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28483577/formoterol-and-fluticasone-propionate-combination-improves-histone-deacetylation-and-anti-inflammatory-activities-in-bronchial-epithelial-cells-exposed-to-cigarette-smoke
#12
M Ferraro, M Gjomarkaj, L Siena, S Di Vincenzo, E Pace
BACKGROUND: The addition of long-acting beta2-agonists (LABAs) to corticosteroids improves asthma control. Cigarette smoke exposure, increasing oxidative stress, may negatively affect corticosteroid responses. The anti-inflammatory effects of formoterol (FO) and fluticasone propionate (FP) in human bronchial epithelial cells exposed to cigarette smoke extracts (CSE) are unknown. AIMS: This study explored whether FP, alone and in combination with FO, in human bronchial epithelial cells line (16-HBE) and primary bronchial epithelial cells (NHBE), counteracted some CSE-mediated effects and in particular some of the molecular mechanisms of corticosteroid resistance...
May 5, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28479192/predictors-of-emergency-department-use-in-children-with-persistent-asthma-in-metropolitan-atlanta-georgia
#13
Jeffery M Franklin, Jocelyn R Grunwell, Alice C Bruce, Robin C Smith, Anne M Fitzpatrick
BACKGROUND: Racial disparities are evident among children with asthma in the United States, with non-Hispanic black children at particularly high risk for poor asthma outcomes, including frequent emergency department (ED) use for asthma exacerbations. OBJECTIVE: To compare asthma features in non-Hispanic black vs white children in Atlanta, Georgia, and determine what clinical features predict future ED use for asthma. METHODS: Self-reported black and white children 6 to 17 years of age with persistent asthma treated with controller medications completed medical history questionnaires, lung function testing, aeroallergen sensitization testing, and venipuncture...
May 4, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28474411/a-trial-of-oral-corticosteroids-for-persistent-systemic-and-airway-inflammation-in-severe-asthma
#14
Keiji Oishi, Tsunahiko Hirano, Ryo Suetake, Syuichiro Ohata, Yoshikazu Yamaji, Kosuke Ito, Nobutaka Edakuni, Kazuto Matsunaga
INTRODUCTION: The fraction of exhaled nitric oxide (FeNO) and blood eosinophils, markers of local and systemic eosinophilic inflammation, respectively, are increased in asthmatic patients. Little is known concerning the relationship between the FeNO levels and blood eosinophils in asthmatics. METHODS: Twenty severe asthmatics with persistent FeNO elevation (≥40 ppb) and blood eosinophilia (≥3%) despite maintenance therapy including high-daily-dose inhaled corticosteroids were analyzed...
May 4, 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28474352/airway-basophils-are-increased-and-activated-in-eosinophilic-asthma
#15
Yoshihiro Suzuki, Keiko Wakahara, Tomoko Nishio, Satoru Ito, Yoshinori Hasegawa
BACKGROUND: The impact of basophils on asthma pathogenesis remains largely unexplored, particularly in humans. Here, we evaluated the frequencies and activation status of basophils in the sputum of adult asthmatic patients and related our findings to other parameters of eosinophilic airway inflammation. METHODS: We enrolled 44 adult asthmatic patients who were being treated with inhaled corticosteroids (ICS). Analysis of the induced sputum, exhaled nitric oxide fraction (FeNO) measurement, and Asthma Control Test (ACT) were carried out together with standard blood and pulmonary function tests...
May 5, 2017: Allergy
https://www.readbyqxmd.com/read/28472499/a-pharmacy-management-service-for-adults-with-asthma-a-cluster-randomised-controlled-trial
#16
Lai-Yan Wong, Siew-Siang Chua, Abdul-Rahman Husin, Hanisah Arshad
Background.: Although clinical guidelines are available for the management of asthma, this health condition is still poorly managed in many countries. Objectives.: To assess the effects of a Pharmacy Management Service (PharMS) on asthma control of adult patients. Methods.: This study comprised of a cluster randomised controlled trial (RCT) that was conducted from April 2014 to July 2015 at four government health clinics. The control participants received usual pharmacy service, while the intervention participants were recruited into the PharMS...
May 3, 2017: Family Practice
https://www.readbyqxmd.com/read/28471703/rhinasthma-patient-perspective-a-rasch-validation-study
#17
Giorgia Molinengo, Ilaria Baiardini, Fulvio Braido, Barbara Loera
OBJECTIVE: In daily practice, Health-Related Quality of Life (HRQoL) tools are useful for supplementing clinical data with the patient's perspective. To encourage their use by clinicians, the availability of tools that can quickly provide valid results is crucial. A new HRQoL tool has been proposed for patients with asthma and rhinitis: the RhinAsthma Patient Perspective-RAPP. The aim of this study was to evaluate the psychometric robustness of the RAPP using the Item Response Theory (IRT) approach, to evaluate the scalability of items and test whether or not patients use the items response scale correctly...
May 4, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28471517/the-duffy-antigen-receptor-for-chemokines-darc-regulates-asthma-pathophysiology
#18
David G Chapman, Edward B Mougey, Jos L Van der Velden, Karolyn G Lahue, Minara Aliyeva, Nirav Daphtary, Katherine L George, Sidra M Hoffman, Robert W Schneider, Russell P Tracy, George S Worthen, Matthew E Poynter, Stephen P Peters, John J Lima, Yvonne Mw Janssen-Heininger, Charles G Irvin
BACKGROUND: The Duffy Antigen Receptor for Chemokines (DARC) is an atypical receptor that regulates pro-inflammatory cytokines. However, the role of DARC in asthma pathophysiology is unknown. OBJECTIVE: To determine the role of DARC in allergic airways disease in mice, and the association between DARC single nucleotide polymorphisms (SNPs) and clinical outcomes in patients with asthma. METHODS: Mice with targeted disruption of the Darc gene (Darc(∆E2) ) or WT mice were challenged over three weeks with house dust mite (HDM) antigen...
May 4, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28465694/visual-analogue-scale-vas-as-a-monitoring-tool-for-daily-changes-in-asthma-symptoms-in-adolescents-a-prospective-study
#19
Hyekyun Rhee, Michael Belyea, Jennifer Mammen
BACKGROUND: Success in asthma management hinges on patients' competency to detect and respond to ever-changing symptom severity. Thus, it is crucial to have reliable, simple, and sustainable methods of symptom monitoring that can be readily incorporated into daily life. Although visual analogue scale (VAS) has been considered as a simple symptom assessment method, its utility as a daily symptom monitoring tool in adolescents is unknown. This study was to determine the concurrent validity of VAS in capturing diurnal changes in symptoms and to examine the relationships between VAS and asthma control and pulmonary function...
2017: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/28464895/predictive-factors-for-moderate-or-severe-exacerbations-in-asthma-patients-receiving-outpatient-care
#20
Francisco Javier Álvarez Gutiérrez, Marta Ferrer Galván, Juan Francisco Medina Gallardo, Marta Barrera Mancera, Beatriz Romero Romero, Auxiliadora Romero Falcón
BACKGROUND: Asthma exacerbations are important events that affect disease control, but predictive factors for severe or moderate exacerbations are not known. The objective was to study the predictive factors for moderate (ME) and severe (SE) exacerbations in asthma patients receiving outpatient care. METHODS: Patients aged > 12 years with asthma were included in the study and followed-up at 4-monthly intervals over a 12-month period. Clinical (severity, level of control, asthma control test [ACT]), atopic, functional, inflammatory, SE and ME parameters were recorded...
May 2, 2017: BMC Pulmonary Medicine
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