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https://www.readbyqxmd.com/read/29773688/understanding-patients-perceptions-of-asthma-control-a-qualitative-study
#1
Natalie Bidad, Neil Barnes, Chris Griffiths, Rob Horne
Asthma control is suboptimal for many sufferers despite the existence of effective treatments. Patients' self-management is influenced by their perceptions of asthma and its treatment. This study explored sufferers' perceptions of asthma control and their influence on self-management behaviours.Participants (n=42) recruited from primary and secondary care asthma clinics in London each underwent a qualitative interview exploring perceptions and experiences of asthma control. Purposive sampling ensured variation in disease severity, degree of asthma control, age and socioeconomic status...
May 17, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29772578/long-term-omalizumab-treatment-a-multicenter-real-life-5-year-trial
#2
Arzu Yorgancıoğlu, Ferda Öner Erkekol, Dilşad Mungan, Münevver Erdinç, Bilun Gemicioğlu, Zeynep Ferhan Özşeker, Papatya Bayrak Değirmenci, Sibel Naycı, Aykut Çilli, Füsun Erdenen, Cengiz Kırmaz, Dane Ediger, Arzu Didem Yalçın, Suna Büyüköztürk, Sami Öztürk, Mustafa Güleç, Sacide Rana Işık, Ali Fuat Kalyoncu, Özlem Göksel, Ömür Aydın, Yavuz Havlucu, İdilhan Baloğlu Ar, Ahmet Erdoğdu
BACKGROUND: Omalizumab has demonstrated therapeutic benefits both in controlled clinical trials and real-life studies. However, research concerning the long-term effects and tolerability of omalizumab is needed. The main objective of this study was to evaluate the effectiveness and tolerability of treatment with omalizumab for up to 5 years. METHODS: A multicenter, retrospective, chart-based study was carried out to compare documented exacerbations, hospitalizations, systemic steroid requirement, FEV1, and asthma control test (ACT) results during 1 year prior to omalizumab treatment versus at 1, 3, and 5 years of treatment...
May 17, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29768147/as-needed-budesonide-formoterol-versus-maintenance-budesonide-in-mild-asthma
#3
Eric D Bateman, Helen K Reddel, Paul M O'Byrne, Peter J Barnes, Nanshan Zhong, Christina Keen, Carin Jorup, Rosa Lamarca, Agnieszka Siwek-Posluszna, J Mark FitzGerald
BACKGROUND: Patients with mild asthma often rely on inhaled short-acting β2 -agonists for symptom relief and have poor adherence to maintenance therapy. Another approach might be for patients to receive a fast-acting reliever plus an inhaled glucocorticoid component on an as-needed basis to address symptoms and exacerbation risk. METHODS: We conducted a 52-week, double-blind, multicenter trial involving patients 12 years of age or older who had mild asthma and were eligible for treatment with regular inhaled glucocorticoids...
May 17, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29765200/efficacy-and-safety-of-the-crth2-antagonist-azd1981-as-add-on-therapy-to-inhaled-corticosteroids-and-long-acting-%C3%AE-2-agonists-in-patients-with-atopic-asthma
#4
Eric D Bateman, Christopher O'Brien, Paul Rugman, Sally Luke, Stefan Ivanov, Mohib Uddin
Objectives: To evaluate the efficacy and safety of AZD1981, a potent, specific antagonist of the CRTh2 receptor, as add-on therapy to inhaled corticosteroids (ICS) and long-acting β2 -agonists (LABA), in patients with persistent asthma with an allergic component. Patients and methods: In this placebo-controlled, parallel-group Phase IIb study, patients with persistent atopic asthma on ICS and LABA were randomized to receive 12 weeks of treatment with placebo or AZD1981 (80 mg daily, 200 mg daily, and 10 mg, 40 mg, 100 mg, or 400 mg twice daily [BID])...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29755809/a-12-week-randomized-parallel-group-phase-iii-study-comparing-the-efficacy-of-once-daily-budesonide-formoterol-turbuhaler-160-4-5-%C3%AE-g-d-with-twice-daily-budesonide-400-%C3%AE-g-d-during-the-step-down-period-in-well-controlled-asthma
#5
Narongwit Nakwan, Thitima Perkleang, Thanida Tamsawai, Pattarawadee Taptawee, Sirikade Usaha
OBJECTIVES: Budesonide/formoterol fumarate (BUD/FF) is recommended in the stepwise management of uncontrolled asthma, but data on a once-daily dose of this medication in a step-down period are lacking. We aimed to compare BUD/FF and BUD in terms of the changes in asthma control scores and lung functions. MATERIAL AND METHODS: This 12-week, randomized, parallel-group, single-center, open-label study was conducted in well-controlled asthmatic patients receiving twice-daily BUD/FF (160/4...
April 2018: Turkish Thoracic Journal
https://www.readbyqxmd.com/read/29755346/a-multicenter-randomized-double-blind-placebo-controlled-study-of-the-effects-of-loki-zupa-in-patients-with-chronic-asthma
#6
Yubao Lv, Ying Wei, Muhammadjan Abduwaki, Tohti Jurat, Fengsen Li, Huaizhen Wang, Yuhua Wu, Zheng Li, Bo Liu, Hongjun Yin, Yuxue Cao, Mammat Nurahmat, Zihui Tang, Jingcheng Dong
The purpose of this study was to evaluate the efficacy and safety of Uyghur medical formula Loki zupa in patients with chronic asthma. Adult patients with chronic asthma randomly received placebo or Loki zupa as add-on to inhaled corticosteroids (ICS) maintenance treatment. Loki zupa or mimics was administered orally 10 ml per time, three times a day for 8 weeks. The primary endpoints were asthma control test (ACT) score and peak expiratory flow (PEF). The secondary endpoints were acute exacerbation rate, lung function, night waking days, and symptom-free days in the near 2 weeks, Asthma Quality of Life Questionnaire (AQLQ) score and some inflammatory cytokines in peripheral blood...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29755048/school-based-interprofessional-asthma-self-management-education-program-for-middle-school-students-a-feasibility-trial
#7
Ellen B Buckner, Donna J Copeland, Kristina S Miller, Timothy Op Holt
BACKGROUND: Asthma is the most common chronic disease among school-aged children under 18 years of age and is a major cause of morbidity, loss of school days, and increased hospitalizations. Asthma disproportionately affects low-income, minority youth in Alabama. The benefits of improving asthma control and self-management have significance for improving health, preventing disease, and reducing health disparities by addressing social, behavioral, environmental, economic, and medical determinants of health...
2018: Progress in Community Health Partnerships: Research, Education, and Action
https://www.readbyqxmd.com/read/29752346/rates-of-asthma-exacerbations-and-mortality-and-associated-factors-in-uganda-a-2-year-prospective-cohort-study
#8
Bruce J Kirenga, Corina de Jong, Levicatus Mugenyi, Winceslaus Katagira, Abdallah Muhofa, Moses R Kamya, H Marike Boezen, Thys van der Molen
Data on asthma treatment outcomes in Africa are limited. 449 patients with asthma (age 5-93 years) in Uganda were followed up for 2 years to determine rates of exacerbations and mortality and associated factors. During follow-up the median number of exacerbations per patient was 1 (IQR 0-5) and 17 patients died (3.7%, 27.3 deaths per 1000 person years). Considering only the first year of follow-up, 59.6% of the patients experienced at least one exacerbation, 32.4% experienced three or more exacerbations. A multivariable model showed that the likelihood of experiencing at least one exacerbation in the first year of follow-up was lower with better baseline asthma control (higher asthma control test (ACT) score), with OR 0...
May 11, 2018: Thorax
https://www.readbyqxmd.com/read/29746201/development-of-a-graphical-tool-to-measure-medication-adherence-in-asthma-patients-a-mixed-methods-pilot-study
#9
Alia Yousif, Catherine Lemière, André Cartier, Amélie Forget, Lucie Blais, For The Resp Investigators
OBJECTIVES: 1) To develop Med-Resp, a graphical tool based on prescription refills to measure adherence and use of asthma medications; 2) To test the feasibility of implementing Med-Resp in a hospital outpatient asthma clinic; 3) To explore the effectiveness of Med-Resp to improve medication adherence to asthma controller medications. METHODS: A sequential exploratory design was used: 1) Prototype design in collaboration with respiratory physicians and patients via focus groups; 2) Med-Resp creation based on algorithms developed and applied to prescription refills data recorded in the drug claims database reMed; 3) Feasibility assessment of the implementation of Med-Resp in the outpatient asthma clinic; and 4) Exploration of the effectiveness of Med-Resp through a pre-post design...
May 10, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29743961/asthma-control-and-asthma-medication-use-among-swedish-elite-endurance-athletes
#10
Hampus Persson, Anne Lindberg, Nikolai Stenfors
Background: Asthma is common in elite athletes. In this study, we examined the use of asthma medication and asthma control in endurance athletes in Sweden and compared the findings with those in a reference group of patients with asthma. Methods: The Asthma Control Test (ACT) and a questionnaire on asthma, respiratory symptoms, and medication use were posted to endurance athletes ( n =711) and the reference group of patients with asthma ( n =1026). Four hundred and sixty-nine athletes (66%) responded, of whom 141 (20%) reported physician-diagnosed asthma...
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/29737044/a-clinical-follow-up-of-omalizumab-in-routine-treatment-of-allergic-asthma-monitored-by-cd-sens
#11
S Gunnar O Johansson, Gunnar Lilja, Jenny Hallberg, Anna Nopp
INTRODUCTION: Omalizumab has been available for treatment of allergic asthma for more than a decade and thus, its efficacy in routine treatment was of interest to evaluate. Basophil allergen threshold sensitivity (CD-sens) has been shown to correlate with the bronchial allergen threshold sensitivity and can be used to objectively measure omalizumab treatment efficacy. We aimed to evaluate the effect of omalizumab treatment of allergic asthma by CD-sens, as an objective marker of the IgE-mediated inflammation, and related to SPT, spirometry, FeNO, Asthma Control Questionnaire (ACQ), and Global Evaluation of Treatment Effectiveness (GETE)...
May 7, 2018: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/29736958/benefits-of-pulmonary-rehabilitation-in-pediatric-asthma
#12
Stephen Kirkby, Allison Rossetti, Don Hayes, Elizabeth Allen, Shahid Sheikh, Benjamin Kopp, Alpa Patel
INTRODUCTION: There are limited studies evaluating the role of pulmonary rehabilitation (PR) in pediatric asthma. METHODS: A retrospective chart review was performed of all pediatric patients with a diagnosis of asthma enrolled in PR. Demographics, medications, and clinical records were reviewed. In addition, PFTs, 6-min walk test (6MWT), and patient/parent symptom and quality of life surveys before and after PR were evaluated. RESULTS: A total of 38 patients were enrolled in PR; 18 (47%) female and 20 (53%) male...
May 7, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29735865/the-prevalence-of-allergic-diseases-among-children-with-asthma-what-is-the-impact-on-asthma-control-in-south-east-nigeria
#13
A C Ayuk, J N Eze, B O Edelu, T Oguonu
Background: Allergic diseases are known to occur in children with asthma and its coexistence with asthma may impact on asthma control in affected children living in a low-income country. The study is to determine the allergic profile of children with asthma and the association with asthma control and attendant social risk factors. Materials and Methods: This was a cross-sectional study of consecutively enrolled children with physician diagnosed asthma, attending clinics in a tertiary center in Nigeria...
May 2018: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29735474/the-detroit-young-adult-asthma-project-proposal-for-a-multicomponent-technology-intervention-for-african-american-emerging-adults-with-asthma
#14
Karen MacDonell, Sylvie Naar, Wanda Gibson-Scipio, Jean-Marie Bruzzese, Bo Wang, Aaron Brody
BACKGROUND: Racial and ethnic minority youth have poorer asthma status than white youth, even after controlling for socioeconomic variables. Proper use of asthma controller medications is critical in reducing asthma mortality and morbidity. The clinical consequences of poor asthma management include increased illness complications, excessive functional morbidity, and fatal asthma attacks. There are significant limitations in research on interventions to improve asthma management in racial minority populations, particularly minority adolescents and young adults, although illness management tends to deteriorate after adolescence during emerging adulthood, the unique developmental period beyond adolescence but before adulthood...
May 7, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29730452/happy-asthma-improved-asthma-control-with-a-gratitude-journal
#15
Kevin A Cook, Katharine M Woessner, Andrew A White
No abstract text is available yet for this article.
May 3, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29730244/family-caregiver-marginalization-is-associated-with-decreased-primary-and-subspecialty-asthma-care-in-head-start-children
#16
S Christy Sadreameli, Kristin A Riekert, Elizabeth C Matsui, Cynthia S Rand, Michelle N Eakin
BACKGROUND: Urban minority children are at risk for poor asthma outcomes and may not receive appropriate primary or subspecialty care. OBJECTIVE: We hypothesized that preschool children with asthma whose caregivers reported more barriers to care would be less likely to have seen their primary care provider (PCP) or an asthma subspecialist and more likely to have had a recent emergency department (ED) visit for asthma. METHODS: The Barriers to Care Questionnaire (BCQ) measures expectations, knowledge, marginalization, pragmatics, and skills...
May 3, 2018: Academic Pediatrics
https://www.readbyqxmd.com/read/29730013/the-impact-of-patient-autonomy-on-older-adults-with-asthma
#17
Keerthi R Karamched, Wei Hao, Peter X Song, Laurie Carpenter, Joel Steinberg, Alan P Baptist
BACKGROUND: Understanding patient preferences and desire for involvement in making medical decisions is important when managing chronic conditions. Previous studies have utilized the Autonomy Preference Index (API) in younger asthmatic patients to evaluate these preferences. OBJECTIVE: To identify factors associated with autonomy, and to determine if autonomy is related to asthma outcomes among older adults. METHODS: 189 older adults (>55 yr) with persistent asthma were included...
May 3, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29725983/liberty-asthma-quest-phase-3-randomized-double-blind-placebo-controlled-parallel-group-study-to-evaluate-dupilumab-efficacy-safety-in-patients-with-uncontrolled-moderate-to-severe-asthma
#18
William W Busse, Jorge F Maspero, Klaus F Rabe, Alberto Papi, Sally E Wenzel, Linda B Ford, Ian D Pavord, Bingzhi Zhang, Heribert Staudinger, Gianluca Pirozzi, Nikhil Amin, Bolanle Akinlade, Laurent Eckert, Jingdong Chao, Neil M H Graham, Ariel Teper
INTRODUCTION: Dupilumab, a fully human anti-IL-4Rα monoclonal antibody, inhibits signaling of both interleukin (IL)-4 and IL-13, which are key drivers of type 2-mediated inflammation. Dupilumab is approved in the EU, USA, and other countries for the treatment of adults with inadequately controlled moderate-to-severe atopic dermatitis. Following positive phase 2 results in asthma, the phase 3 Liberty Asthma QUEST trial was initiated to provide further evidence for dupilumab efficacy and safety in patients with uncontrolled, moderate-to-severe asthma...
May 3, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29724396/the-projected-economic-and-health-burden-of-sub-optimal-asthma-control-in-canada
#19
Zafar Zafari, Mohsen Sadatsafavi, Wenjia Chen, J Mark FitzGerald
BACKGROUND: Achieving optimal control is the primary objective of asthma management. However, despite the existence of effective treatments, many patients experience periods of sub-optimal asthma control. The objective of this study was to quantify and project the future economic and health burden of sub-optimal asthma control in Canada. METHODS: A probabilistic time-in-state model of asthma was created with inputs from published studies on the prevalence of asthma, levels of asthma control, and the impact of asthma control on costs and quality of life...
May 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29724395/asthma-control-in-adults-in-the-middle-east-and-north-africa-results-from-the-esmaa-study
#20
Hesham Tarraf, Hamdan Al-Jahdali, Abdul Hameed Al Qaseer, Anamarija Gjurovic, Houria Haouichat, Basheer Khassawneh, Bassam Mahboub, Roozbeh Naghshin, François Montestruc, Naser Behbehani
BACKGROUND: Low levels of asthma control are reported in many countries worldwide. Improved knowledge of asthma control in the Middle East and Africa and predictive factors is needed to address this major public healthcare burden. OBJECTIVE: To assess the level of asthma control in patients attending a routine consultation for asthma in the Middle East and North Africa, and the relationship between level of control and patient and disease characteristics, adherence, and quality of life (QoL)...
May 2018: Respiratory Medicine
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