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https://www.readbyqxmd.com/read/28091798/intake-of-up-to-3-eggs-day-increases-hdl-cholesterol-and-plasma-choline-while-plasma-trimethylamine-n-oxide-is-unchanged-in-a-healthy-population
#1
Diana M DiMarco, Amanda Missimer, Ana Gabriela Murillo, Bruno S Lemos, Olga V Malysheva, Marie A Caudill, Christopher N Blesso, Maria Luz Fernandez
Eggs are a source of cholesterol and choline and may impact plasma lipids and trimethylamine-N-oxide (TMAO) concentrations, which are biomarkers for cardiovascular disease (CVD) risk. Therefore, the effects of increasing egg intake (0, 1, 2, and 3 eggs/day) on these and other CVD risk biomarkers were evaluated in a young, healthy population. Thirty-eight subjects [19 men/19 women, 24.1 ± 2.2 years, body mass index (BMI) 24.3 ± 2.5 kg/m(2)] participated in this 14-week crossover intervention. Participants underwent a 2-week washout with no egg consumption, followed by intake of 1, 2, and 3 eggs/day for 4 weeks each...
January 13, 2017: Lipids
https://www.readbyqxmd.com/read/28089094/postprandial-clearance-of-oxidized-low-density-lipoprotein-in-patients-with-stroke-due-to-atherosclerosis
#2
Sami Al Kasab, Christy Cassarly, Ngoc-Anh Le, Renee Martin, Julia Brinley, Marc I Chimowitz, Tanya N Turan
BACKGROUND: Oxidized low-density lipoprotein (OxLDL) is a contributor to atherosclerosis development. OxLDL formation increases in the postprandial state due to oxidative stress in subjects with coronary artery disease (CAD) and diabetes, but has not been studied in patients with atherosclerotic stroke. We aimed to determine differences in postprandial OxLDL in patients with atherosclerotic stroke compared to stroke from other causes. METHODS: Patients with ischemic stroke but no history of CAD (n = 42) were enrolled and categorized by stroke subtype as extracranial atherosclerosis (EC), n = 12; intracranial atherosclerosis (IC), n = 16; or other cause, n = 14...
January 6, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28088494/the-n-butyl-alcohol-extract-from-hibiscus-rosa-sinensis-l-flowers-enhances-healing-potential-on-rat-excisional-wounds
#3
Hui-Min Shen, Chun Chen, Ji-Yang Jiang, Yi-Lin Zheng, Wen-Feng Cai, Bin Wang, Zhen Ling, Liu Tang, Yuan-Hang Wang, Gang-Gang Shi
ETHNO-PHARMACOLOGICAL RELEVANCE: Hibiscus rosa-sinensis L. (HRS), a folk medicine named Zhujin in China, possess anti-tumor, antioxidant, antibacterial, low density lipoprotein oxidation prevention and macrophage death prevention effects. The leaves and red flowers of HRS have been traditionally used to treat with furuncle and ulceration. AIM OF THE STUDY: To investigate the efficacy and possible mechanism of the N-butyl alcohol extract of HRS (NHRS) red flowers in wound healing by analyzing the collagen fiber deposition, angiogenic activity and macrophages action of the NHRS...
January 11, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28081247/changes-of-oxidative-stress-glutathione-and-its-dependent-antioxidant-enzyme-activities-in-patients-with-hepatocellular-carcinoma-before-and-after-tumor-resection
#4
Shao-Bin Cheng, Hsiao-Tien Liu, Sin-Yuan Chen, Ping-Ting Lin, Chia-Yu Lai, Yi-Chia Huang
The changes in and relationship between oxidative stress and the glutathione (GSH) antioxidant system in the plasma and tissues of patients with hepatocellular carcinoma (HCC) before and after tumor resection have not been clearly determined. We investigated the changes in oxidative stress, GSH status and its dependent antioxidant enzyme activities in HCC patients before and after tumor resection, and to determine the association of oxidative stress with GSH and its dependent antioxidant enzyme activities in plasma and tissues...
2017: PloS One
https://www.readbyqxmd.com/read/28078862/a-placebo-controlled-trial-of-a-proprietary-lipid-lowering-nutraceutical-supplement-in-the-management-of-dyslipidemia
#5
M Houston, R Rountree, J Lamb, S Phipps, S Meng, B Zhang
There is an ever growing emergence in the popularity of patient-driven care. As this health and wellness model grows, inquiries into diet, lifestyle, and supplemental approaches will continue to become a focal point for the healthcare consumer. Because of this, the aim of this study is to determine the tolerability, and overall effectiveness of a proprietary multi-ingredient lipid-lowering supplement in subjects with dyslipidemia. Forty participants were recruited for a single-center, double-blind randomized, placebocontrolled trial...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28078419/nanostructured-nio-based-reagentless-biosensor-for-total-cholesterol-and-low-density-lipoprotein-detection
#6
Gurpreet Kaur, Monika Tomar, Vinay Gupta
Nanostructured nickel oxide (NiO) thin film has been explored as a matrix to develop a reagentless biosensor for free and total cholesterol as well as low density lipoprotein (LDL) detection. The redox property of the matrix has been exploited to enhance the electron transfer between the enzyme and the electrode as well as to eliminate the toxic mediator in solution. X-ray diffraction, scanning electron microscopy, atomic force microscopy, and Fourier transform infrared spectroscopy were carried out to characterize the NiO thin film...
January 11, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28078249/effects-of-urtica-dioica-supplementation-on-blood-lipids-hepatic-enzymes-and-nitric-oxide-levels-in-type-2-diabetic-patients-a-double-blind-randomized-clinical-trial
#7
Alidad Amiri Behzadi, Hamid Kalalian-Moghaddam, Amir Hossein Ahmadi
OBJECTIVE: Oxidative stress plays an important role in the development of diabetic complications including metabolic abnormality-induced diabetic micro-vascular and macro-vascular complications. Urtica dioica L. (U. dioica) has been traditionally used in Iranian medicine as an herbal remedy for hypoglycemic or due to its anti-inflammatory properties. The aim of the present study was to evaluate the effects of hydro-alcoholic extract of U. dioica on blood lipids, hepatic enzymes and nitric oxide levels in patients with type 2 diabetes mellitus...
November 2016: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28077734/intake-of-up-to-3-eggs-per-day-is-associated-with-changes-in-hdl-function-and-increased-plasma-antioxidants-in-healthy-young-adults
#8
Diana M DiMarco, Gregory H Norris, Courtney L Millar, Christopher N Blesso, Maria Luz Fernandez
BACKGROUND: HDL function may be more important than HDL concentration in determining risk for cardiovascular disease. In addition, HDL is a carrier of carotenoids and antioxidant enzymes, which protect HDL and LDL particles against oxidation. OBJECTIVE: The goal of this study was to determine the impact of consuming 0-3 eggs/d on LDL and HDL particle size, HDL function, and plasma antioxidants in a young, healthy population. METHODS: Thirty-eight healthy men and women [age 18-30 y, body mass index (in kg/m(2)) 18...
January 11, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28072480/free-fatty-acids-induce-autophagy-and-lox-1-upregulation-in-cultured-aortic-vascular-smooth-muscle-cells
#9
Cheng-I Cheng, Yueh-Hong Lee, Po-Han Chen, Yu-Chun Lin, Ming-Huei Chou, Ying-Hsien Kao
Elevation of free fatty acids (FFAs) is known to affect microvascular function and contribute to obesity-associated insulin resistance, hypertension, and microangiopathy. Proliferative and synthetic vascular smooth muscle cells (VSMCs) increase intimal thickness and destabilize atheromatous plaques. This study aimed to investigate whether saturated palmitic acid (PA) and monounsaturated oleic acid (OA) modulate autophagy activity, cell proliferation, and vascular tissue remodeling in an aortic VSMC cell line...
November 5, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28070531/are-serum-levels-of-f2-isoprostane-and-oxidized-ldl-related-to-vitamin-d-status-in-type-2-diabetic-patients-a-case-control-study
#10
Javanbakht Mohammad Hassan, Mohammady Hamed, Fooladsaz Koorosh, Razzaghi Maryam, Zarei Mahnaz, Djalali Mahmoud
BACKGROUND: Considerable evidence suggests that oxidative stress affects diabetes mellitus (DM) and contributes to its complications. Vitamin D has been shown to possess antioxidant properties. The aim of this study was to determine the association between serum levels of calcifediol (25-OH-D), an indicator of vitamin D status, and lipid profiles with oxidative stress in patients with type 2 diabetes mellitus (T2DM). METHODS: In this case-control study, 57 T2DM patients with low vitamin D status (< 30 ng/mL) and 48 T2DM patients with normal vitamin D status (> 30 ng/mL) were enrolled...
October 2016: Reports of Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/28063379/oxidative-stress-mitochondrial-abnormalities-and-antioxidant-defense-in-ataxia-telangiectasia-bloom-syndrome-and-nijmegen-breakage-syndrome
#11
REVIEW
Mateusz Maciejczyk, Bozena Mikoluc, Barbara Pietrucha, Edyta Heropolitanska-Pliszka, Malgorzata Pac, Radosław Motkowski, Halina Car
Rare pleiotropic genetic disorders, Ataxia-telangiectasia (A-T), Bloom syndrome (BS) and Nijmegen breakage syndrome (NBS) are characterised by immunodeficiency, extreme radiosensitivity, higher cancer susceptibility, premature aging, neurodegeneration and insulin resistance. Some of these functional abnormalities can be explained by aberrant DNA damage response and chromosomal instability. It has been suggested that one possible common denominator of these conditions could be chronic oxidative stress caused by endogenous ROS overproduction and impairment of mitochondrial homeostasis...
December 28, 2016: Redox Biology
https://www.readbyqxmd.com/read/28061433/lovastatin-upregulates-microrna-29b-to-reduce-oxidative-stress-in-rats-with-multiple-cardiovascular-risk-factors
#12
Fu Wang, Hui Ma, Wen-Jing Liang, Jing-Jing Yang, Xue-Qing Wang, Mei-Rong Shan, Yuan Chen, Min Jia, Ya-Ling Yin, Xue-Ying Sun, Jia-Ning Zhang, Qi-Sheng Peng, Yu-Guo Chen, Li-Ying Liu, Peng Li, Tao Guo, Shuang-Xi Wang
AIMS: Proteasome-linked oxidative stress is believed to cause endothelial dysfunction, an early event in cardiovascular diseases (CVD). Statin, as HMG-CoA reductase inhibitor, prevents endothelial dysfunction in CVD. However, the molecular mechanism of statin-mediated normalization of endothelial function is not completely elucidated. METHODS AND RESULTS: Lovastatin time/dose-dependently increased miR-29b expression and decreased proteasome activity in cultured human umbilical vein endothelial cells (HUVECs)...
January 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28057795/pleiotropic-effects-of-statins-on-the-cardiovascular-system
#13
REVIEW
Adam Oesterle, Ulrich Laufs, James K Liao
The statins have been used for 30 years to prevent coronary artery disease and stroke. Their primary mechanism of action is the lowering of serum cholesterol through inhibiting hepatic cholesterol biosynthesis thereby upregulating the hepatic low-density lipoprotein (LDL) receptors and increasing the clearance of LDL-cholesterol. Statins may exert cardiovascular protective effects that are independent of LDL-cholesterol lowering called pleiotropic effects. Because statins inhibit the production of isoprenoid intermediates in the cholesterol biosynthetic pathway, the post-translational prenylation of small GTP-binding proteins such as Rho and Rac, and their downstream effectors such as Rho kinase and nicotinamide adenine dinucleotide phosphate oxidases are also inhibited...
January 6, 2017: Circulation Research
https://www.readbyqxmd.com/read/28057601/oxysterols-and-4-hydroxy-2-nonenal-contribute-to-atherosclerotic-plaque-destabilization
#14
Simona Gargiulo, Gabriella Testa, Paola Gamba, Erica Staurenghi, Giuseppe Poli, Gabriella Leonarduzzi
A growing bulk of evidence suggests that cholesterol oxidation products, known as oxysterols, and 4-hydroxy-2-nonenal (HNE), the major proatherogenic components of oxidized low density lipoproteins (oxLDLs), significantly contribute to atherosclerotic plaque progression and destabilization, with eventual plaque rupture. These oxidized lipids are involved in various key steps of this complex process, mainly thanks to their ability to induce inflammation, oxidative stress, and apoptosis. This review summarizes the current knowledge of the effects induced by these compounds on vascular cells, after their accumulation in the arterial wall and in the atherosclerotic plaque...
January 2, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28056545/histone-deacetylase-high-mobility-group-box-1-pathway-targeted-by-hypaconitine-suppresses-the-apoptosis-of-endothelial-cells
#15
Ye Bai, Shaohui Du, Fei Li, Fengyuan Huang, Rudong Deng, Jianhong Zhou, Dongfeng Chen
Hypaconitine is an active component of Aconitum carmichaelii Debx, a Chinese medicinal herb for the treatment of cardiovascular diseases, but the mechanism underlying its effect remains elusive. In this study, we found that hypaconitine, rather than aconitum alkaloids in A. carmichaelii (e.g. aconitine, mesaconitine and benzoylaconitine), prevented endothelial cells from damage due to oxidized low-density lipoprotein (oxLDL) challenge. Cleaved caspase 3 expression in endothelial cells was up-regulated by oxLDL and markedly attenuated by hypaconitine, suggesting that hypaconitine inhibited the oxLDL-induced cell apoptosis...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28053615/antioxidant-and-hepatoprotective-effects-of-fermented-red-ginseng-against-high-fat-diet-induced-hyperlipidemia-in-rats
#16
Myeong-Hwan Kim, Eun-Jin Lee, Jeong-Mu Cheon, Ki-Jun Nam, Tae-Ho Oh, Kil-Soo Kim
This study was performed to investigate the antioxidant and hepatoprotective effects of fermented red ginseng (Panax ginseng C.A. Meyer; FRG) on high-fat diet-induced hyperlipidemia in rats. Sprague-Dawley rats were divided into four groups of seven: normal control, NC; high-fat diet control, HFC; high-fat diet-0.5% FRG, HF-FRGL; and high-fat diet-1% FRG, HF-FRGH. All rats were fed a high-fat diet for eight weeks, except those in the NC group, while rats in the FRG treatment groups received drinking water containing 0...
December 2016: Laboratory Animal Research
https://www.readbyqxmd.com/read/28052815/how-do-macrophages-sense-modified-low-density-lipoproteins
#17
REVIEW
Dimitry A Chistiakov, Alexandra A Melnichenko, Alexander N Orekhov, Yuri V Bobryshev
In atherosclerosis, serum lipoproteins undergo various chemical modifications that impair their normal function. Modification of low density lipoprotein (LDL) such as oxidation, glycation, carbamylation, glucooxidation, etc. makes LDL particles more proatherogenic. Macrophages are responsible for clearance of modified LDL to prevent cytotoxicity, tissue injury, inflammation, and metabolic disturbances. They develop an advanced sensing arsenal composed of various pattern recognition receptors (PRRs) capable of recognizing and binding foreign or altered-self targets for further inactivation and degradation...
December 28, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/28049882/the-relationship-between-circulating-neutrophil-gelatinase-associated-lipocalin-and-early-alteration-of-metabolic-parameters-is-associated-with-dietary-saturated-fat-intake-in-non-diabetic-korean-women
#18
Ga Yoon Na, So Ra Yoon, Juhyun An, Rimkyo Yeo, Juhyun Song, Mi-Na Jo, Seongho Han, Oh Yoen Kim
Circulating neutrophil gelatinase-associated lipocalin (NGAL) is associated with obesity-related metabolic disorders. This study investigated the relationship between serum NGAL and early alteration of metabolic parameters in non-diabetic Korean women, particularly with respect to saturated fat (SFA) intake. Anthropometric parameters, fasting glycemic status, and levels of lipids, oxidative stress/inflammatory markers, and NGAL were measured in 82 non-diabetic Korean women [Super-healthy group (n=57) with 0 metabolic syndrome risk factor (MetS RF) and MetS-risk group (n=25) with MetS RF≥1]...
December 30, 2016: Endocrine Journal
https://www.readbyqxmd.com/read/28048943/modeling-small-angle-x-ray-scattering-data-for-low-density-lipoproteins-insights-into-the-fatty-core-phase-packing-and-transition
#19
Selma Maric, Tania Kjellerup Lind, Jeppe Lyngsø, Marite Cardenas, Jan Skov Pedersen
Atherosclerosis and its clinical consequences are the leading cause of death in the west. While many studies throughout the last decades have aimed at understanding the disease, the clinical markers in use today still fail to accurately predict the risks. The role of the main clinical indicator of today, the low density lipoprotein (LDL), in depositing fat to the vessel wall is believed to be the onset of the process. However, many subfractions of the LDL, which differ both in structure and composition, are present in the blood and amongst different individuals...
January 3, 2017: ACS Nano
https://www.readbyqxmd.com/read/28044466/brief-communication-plasma-lipid-oxidation-predicts-atherosclerotic-status-better-than-cholesterol-in-diabetic-apolipoprotein-e-deficient-mice
#20
Karen Ekkelund Petersen, Jens Lykkesfeldt, Kirsten Raun, Günaj Rakipovski
Increased levels of oxidative stress have been suggested to play a detrimental role in the development of diabetes-related vascular complications. Here, we investigated whether the concentration of malondialdehyde, a marker of lipid oxidation correlated to the degree of aortic plaque lesions in a proatherogenic diabetic mouse model. Three groups of apolipoprotein E knockout mice were studied for 20 weeks, a control, a streptozotocin-induced diabetic, and a diabetic enalapril-treated group. Enalapril was hypothesized to lower oxidative stress level and thus the plaque burden...
January 2017: Experimental Biology and Medicine
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