keyword
https://read.qxmd.com/read/38536819/stem-cell-derived-vessels-on-chip-for-cardiovascular-disease-modeling
#1
JOURNAL ARTICLE
Maren Marder, Caroline Remmert, Julius A Perschel, Munkhtur Otgonbayar, Christine von Toerne, Stefanie Hauck, Judith Bushe, Annette Feuchtinger, Bilal Sheikh, Michel Moussus, Matthias Meier
The metabolic syndrome is accompanied by vascular complications. Human in vitro disease models are hence required to better understand vascular dysfunctions and guide clinical therapies. Here, we engineered an open microfluidic vessel-on-chip platform that integrates human pluripotent stem cell-derived endothelial cells (SC-ECs). The open microfluidic design enables seamless integration with state-of-the-art analytical technologies, including single-cell RNA sequencing, proteomics by mass spectrometry, and high-resolution imaging...
March 26, 2024: Cell Reports
https://read.qxmd.com/read/38536049/circ_0104652-promotes-the-proliferation-and-migration-of-ox-ldl-stimulated-vascular-smooth-muscle-cells-via-stabilizing-adamts7-and-hmgb1
#2
JOURNAL ARTICLE
Bo Bian, Heye Chen, Tianming Teng, Jinyong Huang, Xuefang Yu
BACKGROUND: Atherosclerosis (AS) stands as the primary contributor to cardiovascular disease (CVD), a pervasive global health concern. Extensive research has underscored the pivotal role of circular RNAs (circRNAs) in CVD development. However, the specific functions of numerous circRNAs in AS remain poorly understood. METHODS: Quantitative real-time PCR (RT-qPCR) analysis revealed a significant up-regulation of circ_0104652 in oxidized low-density lipoprotein (ox-LDL)-induced vascular smooth muscle cells (VSMCs)...
March 27, 2024: American Journal of Hypertension
https://read.qxmd.com/read/38535952/a-proof-of-concept-for-a-hypolipidemic-brown-trout-model
#3
JOURNAL ARTICLE
Tiago Lourenço, Eduardo Rocha, José Fernando Gonçalves, Maria João Rocha, Tânia Vieira Madureira
The impacts of hypolipidemic pharmaceuticals on fish lipid metabolism remain unexplored. However, data points to similar effects and mechanisms of action between fish and humans. Therefore, fish may be a strong model for screening hypolipidemic drug candidates and water pollution by lipid-modulating agents. This study aimed to test a new hypolipidemic model assay with juvenile brown trout using atorvastatin (ATV)-a hypolipidemic chemical. We selected 17α-ethinylestradiol (EE2), known to cause hyperlipidemia in fish, to ensure model functionality...
March 15, 2024: Toxics
https://read.qxmd.com/read/38533288/protective-effect-of-baclofen-on-ovarian-cystogenesis-and-morphine-induced-lipid-profile-change-in-female-rats
#4
JOURNAL ARTICLE
Zahra Jamshidi, Manizheh Karami, Mohsen Khalili, Mehrdad Roghani
INTRODUCTION: Morphine induces ovarian cysts that cause obesity and disrupt sex hormone secretion. Baclofen, a gamma-aminobutyric acid receptor agonist, can help regulate sex hormones and reduce harmful blood lipids by protecting against morphine-induced gamma-aminobutyric acid inhibition. We investigated the prophylactic effect of baclofen in rats receiving morphine by comparing with the untreated groups. MATERIALS AND METHODS: Forty eight female Wistar rats were randomly divided into several groups, including control (saline 1 mL/kg, i...
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38531797/knockdown-of-linc01128-downregulates-fut8-to-inhibit-oxldl-induced-vascular-smooth-muscle-cell-apoptosis-in-atherosclerosis
#5
JOURNAL ARTICLE
Guozhen Ni, Jian Xu
BACKGROUND: The apoptosis of vascular smooth muscle cells (VSMCs) contributes to the progression of atherosclerosis (AS). Long intergenic non-protein coding RNA 1128 (LINC01128) has been implicated in AS, and this study aims to uncover the role and mechanism of LINC01128 in regulating oxidized low-density lipoprotein (oxLDL)-induced VSMCs. METHODS: The position of LINC01128 in cells and its target genes were predicted using bioinformatics. The localization of LINC01128 in human VSMCs was determined through fluorescence in situ hybridization...
March 2024: Discovery Medicine
https://read.qxmd.com/read/38531794/creation-of-an-atherosclerosis-model-using-palmitic-acid-and-oleic-acid-in-the-vascular-smooth-muscle-cells-of-rats
#6
JOURNAL ARTICLE
Fan Zhang, Guangping Li, Xueyin Li, Yi Zheng, Wanting Du, Bo Zhao, Da Sun
BACKGROUND: Atherosclerosis (AS) is a chronic vascular inflammatory disease resulting from vascular endothelial injury and lipid deposition, closely linked to abnormal lipid metabolism within the body. The critical processes involved in atherosclerosis encompass lipid deposition, oxidation, metabolic disruptions, and inflammatory stimulation within the inner vessel wall. Lipid deposition emerges as a pivotal factor triggering these pathological changes, with vascular smooth muscle cells (VSMCs) playing a significant role in the development of AS...
March 2024: Discovery Medicine
https://read.qxmd.com/read/38531501/effects-of-moderate-ethanol-exposure-on-risk-factors-for-cardiovascular-disease-and-colorectal-cancer-in-adult-wistar-rats
#7
JOURNAL ARTICLE
Anna J Kwon, Lani Morales, Louise Chatagnier, Jacqueline Quigley, Jeremy Pascua, Natalie Pinkowski, Susan M Brasser, Mee Young Hong
While past studies have provided evidence linking excessive alcohol consumption to increased risk for cardiovascular diseases (CVDs) and colorectal cancer (CRC), existing data on the effects of moderate alcohol use on these conditions have produced mixed results. The purpose of this study was to investigate the effects of moderate alcohol consumption on risk factors associated with the development of CVDs and CRC in adult rats. Twenty-four, 14-month-old, non-deprived male Wistar rats were randomly assigned to either an ethanol group, which consisted of voluntary access to a 20% (v/v) ethanol solution on alternate days, or a water control group (n = 12/group) for 13 weeks...
March 24, 2024: Alcohol
https://read.qxmd.com/read/38529199/beneficial-role-of-amygdalin-extracts-against-animal-growth-regulator-boldjan-induced-cardiac-toxicity-injury-and-oxidative-stress-in-male-rats
#8
JOURNAL ARTICLE
Eman M Hussain, Sura M Alkadhimy, Asmaa M Neamah, Ehab Tousson
Millions of individuals have used illicit anabolic-androgenic steroids (AAS), but the long-term cardiovascular associations of these drugs remain incompletely understood. Boldjan is AAS medication which is used in veterinary medicine and by young adults aiming to have a better appearance improving their self-esteem. Therefore; the objective of the current investigation was to examine any potential preventative effects of amygdalin extract against anabolic steroid Boldjan induced cardic toxicity, injury and oxidative stress in male rat...
April 2024: Toxicology Research
https://read.qxmd.com/read/38529014/invigorating-human-mscs-for-transplantation-therapy-via-nrf2-dkk1-co-stimulation-in-an-acute-on-chronic-liver-failure-mouse-model
#9
JOURNAL ARTICLE
Feng Chen, Zhaodi Che, Yingxia Liu, Pingping Luo, Lu Xiao, Yali Song, Cunchuan Wang, Zhiyong Dong, Mianhuan Li, George L Tipoe, Min Yang, Yi Lv, Hong Zhang, Fei Wang, Jia Xiao
BACKGROUND: Since boosting stem cell resilience in stressful environments is critical for the therapeutic efficacy of stem cell-based transplantations in liver disease, this study aimed to establish the efficacy of a transient plasmid-based preconditioning strategy for boosting the capability of mesenchymal stromal cells (MSCs) for anti-inflammation/antioxidant defenses and paracrine actions in recipient hepatocytes. METHODS: Human adipose mesenchymal stem cells (hADMSCs) were subjected to transfer, either with or without the nuclear factor erythroid 2-related factor 2 (Nrf2)/Dickkopf1 (DKK1) genes, followed by exposure to TNF-α/H2 O2 ...
2024: Gastroenterology Report
https://read.qxmd.com/read/38525555/lactiplantibacillus-plantarum-strains-kabp011-kabp012-and-kabp013-modulate-bile-acids-and-cholesterol-metabolism-in-humans
#10
JOURNAL ARTICLE
T Padro, V de Santisteban, P Huedo, M Puntes, M Aguiló, J Espadaler-Mazo, L Badimon
AIMS: Probiotics with high bile salt hydrolase (BSH) activity have shown to promote cardiovascular health. However, their mechanism(s) of action remain poorly understood. Here, we performed a pilot exploratory study to investigate effects of a 4-week intervention with escalating doses of a BSH-active formula containing Lactiplantibacillus plantarum strains KABP011, KABP012 and KABP013 on bile acid (BA), lipid profile and lipoprotein function. METHODS AND RESULTS: Healthy overweight individuals were included in this study...
March 25, 2024: Cardiovascular Research
https://read.qxmd.com/read/38523733/resistance-training-in-cardiovascular-diseases-a-review-on-its-effectiveness-in-controlling-risk-factors
#11
REVIEW
Arnengsih Nazir, Henhen Heryaman, Cep Juli, Azizah Ugusman, Januar Wibawa Martha, Marina Annette Moeliono, Nur Atik
Cardiovascular Disease (CVD), a term encompassing various disorders affecting the heart and blood vessels, includes coronary artery disease (CAD). CAD is primarily due to the development of atherosclerotic plaques that disrupt blood flow, oxygenation, and nutrient delivery to the myocardium. Risk factors contributing to CAD progression include smoking, hypertension, diabetes mellitus (DM), dyslipidaemia, and obesity. While aerobic exercise (AE) has shown promising results in controlling CVD risk factors, the impact of resistance training (RT) has not been extensively investigated...
2024: Integrated Blood Pressure Control
https://read.qxmd.com/read/38523689/fto-stabilizes-mis12-to-inhibit-vascular-smooth-muscle-cell-senescence-in-atherosclerotic-plaque
#12
JOURNAL ARTICLE
Jingzhao Sun, Mengqi Wang, Fengming Jia, Jiantao Song, Jinlin Ren, Bo Hu
PURPOSE: Atherosclerosis is the main cause of atherosclerotic cardiovascular disease (CVD). Here, we aimed to uncover the role and mechanisms of fat mass and obesity-associated genes (FTO) in the regulation of vascular smooth muscle cell (VSMC) senescence in atherosclerotic plaques. METHODS: ApoE-/- mice fed a high-fat diet (HFD) were used to establish an atherosclerotic animal model. Immunohistochemistry, and the staining of hematoxylin-eosin, Oil Red O, Sirius red, and Masson were performed to confirm the role of FTO in atherosclerosis in vivo...
2024: Journal of Inflammation Research
https://read.qxmd.com/read/38523341/inhibition-of-oxidized-low-density-lipoprotein-with-orticumab-inhibits-coronary-inflammation-and-reduces-residual-inflammatory-risk-in-psoriasis-a-pilot-randomized-double-blind-placebo-controlled-trial
#13
JOURNAL ARTICLE
Christopher J Farina, Michael H Davidson, Prediman K Shah, Charles Stark, Wenqi Lu, Cheerag Shirodaria, Timothy Wright, Charalambos A Antoniades, Jan Nilsson, Nehal N Mehta
No abstract text is available yet for this article.
March 25, 2024: Cardiovascular Research
https://read.qxmd.com/read/38522226/serum-lipids-and-cognitive-outcomes-in-multiple-sclerosis-a-systematic-review-and-meta-analysis
#14
REVIEW
Sarvin Sanaie, Narges Koohi, Reza Mosaddeghi-Heris, Shirin Rezai, Elahe Movagharnia, Hanie Karimi, Seyedehyasmin Moghaddamziabari, Sina Hamzehzadeh, Elnaz Gholipour-Khalili, Mahnaz Talebi, Amirreza Naseri
BACKGROUND: Cognitive impairment is highly prevalent in multiple sclerosis (MS) with poorly understood underlying mechanisms. Lipids are considered to be associated with MS progression through the inflammatory and oxidative stress pathways, brain atrophy, cellular signaling, and tissue physiology. In addition, serum lipids are proposed as a modifiable factor affecting the neuropsychiatric condition; therefore, this study aims to assess the association between serum lipid levels and cognitive outcomes in MS...
February 29, 2024: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/38521431/qixian-granule-inhibits-ferroptosis-in-vascular-endothelial-cells-by-modulating-trpml1-in-the-lysosome-to-prevent-postmenopausal-atherosclerosis
#15
JOURNAL ARTICLE
Meng Zhang, Chenhan Mao, Yang Dai, Xiaojin Xu, Xindong Wang
ETHNOPHARMACOLOGICAL RELEVANCE: QiXian Granule (QXG) is an integrated traditional Chinese medicine formula used to treat postmenopausal atherosclerotic (AS) cardiovascular diseases. The previous studies have found that QXG inhibited isoproterenol (ISO)-induced myocardial remodeling. And its active ingredient, Icraiin, can inhibit ferroptosis by promoting oxidized low-density lipoprotein (xo-LDL)-induced vascular endothelial cell injury and autophagy in atherosclerotic mice. Another active ingredient, Salvianolic Acid B, can suppress ferroptosis and apoptosis during myocardial ischemia/reperfusion injury by reducing ubiquitin-proteasome degradation of Glutathione Peroxidase 4 (GPX4) and down-regulating the reactive oxygen species (ROS)- c-Jun N-terminal kinases (JNK)/mitogen-activated protein kinase (MAPK) pathway...
March 21, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38521293/folic-acid-and-plasma-lipids-interactions-and-effect-of-folate-supplementation
#16
REVIEW
Federica Fogacci, Carmine Pizzi, Luca Bergamaschi, Valentina Di Micoli, Arrigo F G Cicero
Dyslipidaemia and hyperhomocysteinemia are known risk factors for cardiovascular disease. While it is evident that optimization of plasma lipid is associated with low risk of cardiovascular disease in the general population, it is not yet fully clear whether reduction of homocysteinemia is associated with an improvement in risk in all subjects. The aim of our narrative review is to highlight eventual effects of folate supplementation on LDL-C levels, LDL-C oxidation and atherosclerosis-related complications...
March 21, 2024: Current Problems in Cardiology
https://read.qxmd.com/read/38518720/the-anti-atherosclerotic-effect-of-paeonol-against-the-lipid-accumulation-in-macrophage-derived-foam-cells-by-inhibiting-ferroptosis-via-the-sirt1-nrf2-gpx4-signaling-pathway
#17
JOURNAL ARTICLE
Menglong Gao, Lishun Dong, Yulong Yang, Jinjin Yan, Yuning Liang, Xiaolin Ma, Min Zhou, Hongfei Wu, Yarong Liu, Min Dai
Atherosclerosis (AS) is the underlying cause of many severe vascular diseases and is primarily characterized by abnormal lipid metabolism. Paeonol (Pae), a bioactive compound derived from Paeonia Suffruticosa Andr., is recognized for its significant role in reducing lipid accumulation. Our research objective is to explore the link between lipid buildup in foam cells originating from macrophages and the process of ferroptosis, and explore the effect and mechanism of Pae on inhibiting AS by regulating ferroptosis...
March 14, 2024: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/38518640/aqueous-extract-of-fermented-eucommia-ulmoides-leaves-alleviates-hyperlipidemia-by-maintaining-gut-homeostasis-and-modulating-metabolism-in-high-fat-diet-fed-rats
#18
JOURNAL ARTICLE
Yu Duan, Fengqian Guo, Chun Li, Dinghua Xiang, Man Gong, Hong Yi, Liangmian Chen, Lihua Yan, Dong Zhang, Liping Dai, Xiaoqian Liu, Zhimin Wang
BACKGROUND: As a traditional Chinese medicinal herb, the lipid-lowing biological potential of Eucommia ulmoides leaves (EL) has been demonstrated. After fermentation, the EL have been made into various products with lipid-lowering effects and antioxidant activity. However, the anti-hyperlipidemic mechanism of fermented Eucommia ulmoides leaves (FEL) is unclear now. PURPOSE: To evaluate the effects of FEL on hyperlipidemia and investigate the mechanism based on regulating gut homeostasis and host metabolism...
December 27, 2023: Phytomedicine
https://read.qxmd.com/read/38518636/gualou-xiebai-herb-pair-and-its-active-ingredients-act-against-atherosclerosis-by-suppressing-vsmc-derived-foam-cell-formation-via-regulating-p2ry12-mediated-lipophagy
#19
JOURNAL ARTICLE
Youli Bao, Li Zhu, Yuting Wang, Jiahui Liu, Zijian Liu, Zhenglong Li, An Zhou, Hongfei Wu
BACKGROUND: Atherosclerosis (AS) is a chronic disease characterized by lipid accumulation in the aortic wall and the formation of foam cells overloaded with large lipids inclusions. Currently, Western medicine is primarily used to improve lipid metabolism disorders and reduce inflammatory reactions to delay AS progression, but these medicines come with serious side effects and drug resistance. Gualou-Xiebai (GLXB) is a renowned herb pair that has been proven effective against AS. However, the potential molecular mechanism through which GLXB exerts the anti-atherosclerotic effects of increasing lipophagy in vascular smooth muscle cells (VSMCs) remains unknown...
January 7, 2024: Phytomedicine
https://read.qxmd.com/read/38516841/naringenin-inhibits-acid-sphingomyelinase-mediated-membrane-raft-clustering-to-reduce-nadph-oxidase-activation-and-vascular-inflammation
#20
JOURNAL ARTICLE
Meng Ding, Yuan Zhu, Xiaoting Xu, Hui He, Tianyu Jiang, Xiaochuan Mo, Zhuting Wang, Wenfeng Yu, Hailong Ou
Macrophage inflammation and oxidative stress promote atherosclerosis progression. Naringenin is a naturally occurring flavonoid with antiatherosclerotic properties. Here, we elucidated the effects of naringenin on monocyte/macrophage endothelial infiltration and vascular inflammation. We found naringenin inhibited oxidized low-density lipoprotein (oxLDL)-induced pro-inflammatory cytokines such as IL-1β, IL-6, and TNF-α toward an M2 macrophage phenotype and inhibited oxLDL-induced TLR4 (Toll-like receptor 4) membrane translocation and downstream NF-κB transcriptional activity...
March 22, 2024: Journal of Agricultural and Food Chemistry
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