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https://www.readbyqxmd.com/read/28917868/anti-hyperlipidemic-and-antioxidant-effects-of-alkali-extractable-mycelia-polysaccharides-by-pleurotus-eryngii-var-tuolensis
#1
Zhenzhen Ren, Juan Li, Nuo Xu, Jianjun Zhang, Xinling Song, Xiuxiu Wang, Zheng Gao, Huijuan Jing, Shangshang Li, Chen Zhang, Min Liu, Huajie Zhao, Le Jia
In this study, we noted that the Al-MPS from Pleurotus eryngii var. tuolensis provoked pharmacological effects on blood lipid profiles and oxidative stress. Animal studies demonstrated that Al-MPS showed potential effects on relieving hyperlipidemia and preventing oxidative stress, reflecting by decreasing the levels of serum enzyme activities (ALP, ALT and AST), restoring the activities of antioxidant enzymes (SOD, GSH-Px, CAT and T-AOC), down-regulating the MDA and LPO contents, as well as remitting the hepatic and cardiac tissues injury, respectively...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28915447/oxidative-stress-induced-modulation-of-platelet-integrin-%C3%AE-2b%C3%AE-3-expression-and-shedding-may-predict-the-risk-of-major-bleeding-in-heart-failure-patients-supported-by-continuous-flow-left-ventricular-assist-devices
#2
Nandan K Mondal, Zengsheng Chen, Jaimin R Trivedi, Erik N Sorensen, Si M Pham, Mark S Slaughter, Bartley P Griffith, Zhongjun J Wu
INTRODUCTION: Oxidative stress and platelet integrin α2bβ3 plays important role in the process of hemostasis and thrombosis. We hypothesized that device-induced patient specific oxidative stress and integrin α2bβ3 shedding may be linked to major bleeding complication (MBC) in heart failure (HF) patients supported by continuous flow left ventricular assist devices (CF-LVADs). MATERIALS AND METHODS: We recruited 47patients implanted with CF-LVADs and 15 healthy volunteers...
September 8, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28913715/oxidized-low-density-lipoprotein-oxldl-affects-load-free-cell-shortening-of-cardiomyocytes-in-a-proprotein-convertase-subtilisin-kexin-9-pcsk9-dependent-way
#3
Klaus-Dieter Schlüter, Annemarie Wolf, Martin Weber, Rolf Schreckenberg, Rainer Schulz
Recent studies have documented that oxidized low-density lipoprotein cholesterol (oxLDL) levels directly impact myocardial structure and function. However, the molecular mechanisms by which oxLDL affects cardiac myocytes are not well established. We addressed the question whether oxLDL modifies load-free cell shortening, a standardized readout of cardiac cellular function, and investigated whether proprotein convertase subtilisin/kexin-9 (PCSK9) is involved on oxLDL-dependent processes. Adult rat ventricular cardiomyocytes were isolated and incubated for 24 h with oxLDL...
September 14, 2017: Basic Research in Cardiology
https://www.readbyqxmd.com/read/28912752/disparities-in-cardiovascular-disease-and-type-2-diabetes-risk-factors-in-blacks-and-whites-dissecting-racial-paradox-of-metabolic-syndrome
#4
REVIEW
Kwame Osei, Trudy Gaillard
Cardiovascular diseases (CVD) remain as the leading cause of mortality in the western world and have become a major health threat for developing countries. There are several risk factors that account for the CVD and the associated mortality. These include genetics, type 2 diabetes (T2DM), obesity, physical inactivity, hypertension, and abnormal lipids and lipoproteins. The constellation of these risk factors has been termed metabolic syndrome (MetS). MetS varies among racial and ethnic populations. Thus, race and ethnicity account for some of the differences in the MetS and the associated CVD and T2DM...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28912717/global-metabolomics-reveals-the-metabolic-dysfunction-in-ox-ldl-induced-macrophage-derived-foam-cells
#5
Wenjuan Xu, Ziyi Wei, Jiaojiao Dong, Feipeng Duan, Kuikui Chen, Chang Chen, Jie Liu, Xiaowei Yang, Lianming Chen, Hongbin Xiao, An Liu
Atherosclerosis (AS) is a chronic disorder of large arteries that is a major risk factors of high morbidity and mortality. Oxidative modification LDL is one of the important contributors to atherogenesis. Macrophages take up ox-LDL and convert into foam cells, which is the hallmark of AS. To advance the understanding of the metabolic perturbation involved in ox-LDL induced macrophage-derived foam cells and discover the potential biomarkers of early AS, a global metabolomics approach was applied based on UHPLC-QTOF/MS...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28904866/imm-h007-a-new-therapeutic-candidate-for-nonalcoholic-fatty-liver-disease-improves-hepatic-steatosis-in-hamsters-fed-a-high-fat-diet
#6
Huijie Shi, Qingchun Wang, Liu Yang, Shouxia Xie, Haibo Zhu
Nonalcoholic fatty liver disease (NAFLD), the most common chronic liver disease in humans, is characterized by the accumulation of triacylglycerols (TGs) in hepatocytes. We tested whether 2',3',5'-tri-acetyl-N6-(3-hydroxylaniline) adenosine (IMM-H007) can eliminate hepatic steatosis in hamsters fed a high-fat diet (HFD), as a model of NAFLD. Compared with HFD-only controls, IMM-H007 treatment significantly lowered serum levels of TG, total cholesterol, and free fatty acids (FFAs) in hamsters fed the HFD, with a prominent decrease in levels of serum transaminases and fasting insulin, without affecting fasting glucose levels...
September 2017: FEBS Open Bio
https://www.readbyqxmd.com/read/28904738/total-oxidant-and-antioxidant-status-in-prepubertal-children-with-obesity
#7
Grażyna Rowicka, Hanna Dyląg, Jadwiga Ambroszkiewicz, Agnieszka Riahi, Halina Weker, Magdalena Chełchowska
AIMS: Obesity is accompanied by the formation of oxygen free radicals, whose intensified activity without effective defense mechanisms can lead to oxidative stress and related complications. We evaluated the presence of oxidative stress in obese prepubertal children. METHODS: The study included 83 healthy children aged 2-10 years (62 with obesity and 21 nonobese controls). Total oxidant capacity (TOC), total antioxidant capacity (TAC), oxidized low-density lipoprotein (ox-LDL), lipid parameters, glucose, and C-reactive protein (CRP) were measured in serum...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28902644/serum-oxidized-low-density-lipoprotein-level-as-a-marker-of-oxidative-stress-in-patients-undergoing-hyperbaric-oxygen-therapy
#8
Kudret Keskin, Hakan Kilci, Gökhan Aksan, Gökhan Çetinkal, Süleyman Sezai Yıldız, Füsun Kocaman Türk, Gülsüm Bingöl
OBJECTIVE: Oxidative stress (OS) is involved in the pathogenesis of atherosclerosis. Hyperbaric oxygen therapy (HBOT), in which 100% oxygen is inhaled under hyperbaric pressure, may create OS. Therefore, the aim of this research was to measure the serum oxidized low-density lipoprotein (oxLDL) level in patients undergoing HBOT. METHODS: Twenty-nine patients who underwent HBOT to treat various diseases were enrolled in this study. The serum oxLDL level was measured at the beginning of the first and after the 10th therapy session...
September 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28899694/anti-atherosclerotic-effect-of-hesperidin-in-ldlr-mice-and-its-possible-mechanism
#9
Ye-Zi Sun, Jian-Fei Chen, Li-Min Shen, Ji Zhou, Cui-Fang Wang
Hesperidin, a citrus bioflavonoid, exerts numerous pharmacological activities. However, its protective effect against atherosclerosis in vivo remains poorly understood. In the present study, we aimed to observe the effects of hesperidin on high fat diet (HFD)-induced atherosclerosis using LDL receptor deficient (LDLr(-/-)) mice. After 12 weeks of treatment, the animals were sacrificed. The blood samples were collected for further analysis. Mouse peritoneal macrophages were collected. Hepatic lipid content, quantification of atherosclerosis, assessment of oxidative stress and inflammation, gene expressions were performed on liver and aorta samples...
September 9, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28899395/role-of-rab5-in-the-formation-of-macrophage-derived-foam-cell
#10
Lokwern Chan, Jin Hong, Junjie Pan, Jian Li, Zhichao Wen, Haiming Shi, Jianping Ding, Xinping Luo
BACKGROUND: Foam cells play a key role in the occurrence and pathogenesis of atherosclerosis. Its formation starts with the ingestion of oxidized low-density lipoprotein (oxLDL). The process is associated with Ras related protein in brain 5 (Rab5) which plays a critical role in regulating endocytosis and early endosomal trafficking. Base on this, we presumed that Rab5 might participate in the maturation of foam cell. The aim of this study is to investigate the effect of Rab5 on macrophage cholesterol during the evolvement of macrophage when induced by oxLDL to the formation of foam cell...
September 12, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28899001/a-role-for-autoantibodies-in-atherogenesis
#11
Rosebella A Iseme, Mark McEvoy, Brian Kelly, Linda Agnew, Frederick R Walker, Tonelle Handley, Christopher Oldmeadow, John Attia, Michael Boyle
An increased risk of cardiovascular disease (CVD) has long been recognized amongst people with autoimmune disease. It has been unclear whether this is due mainly to the ensuing treatment, particularly steroids, or whether some of this risk is due to the autoimmune process itself with subsequent inflammation. Indeed, a large body of evidence supports a role for chronic inflammation in atherogenesis, and autoantibodies have been identified as mediators in this complex inflammatory environment. Our aim is to carry out a systematic review of existing literature in order to formally establish the strength of the association between autoantibodies and atherosclerosis, amongst individuals without clinical autoimmune disease...
August 1, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28898769/lox-1-is-involved-in-il-1%C3%AE-production-and-extracellular-matrix-breakdown-in-dental-peri-implantitis
#12
Chengye Che, Jie Liu, Lei Ma, Huirong Xu, Na Bai, Qian Zhang
PURPOSE: To explore whether lectin-type oxidized LDL receptor 1 (LOX-1), interleukin 1 beta (IL-1β), matrix metalloproteinase 2 (MMP2) and matrix metalloproteinase 9 (MMP9) are involved in the nosogenesis of human dental peri-implantitis and determine the role of LOX-1 in IL-1β, MMP2 and MMP9 production in response to Porphyromonas gingivalis. METHODS: Peri-implant crevicular fluid (PICF) was collected from ten patients with healthy implants and ten patients with peri-implantitis...
September 9, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28891115/deficiency-of-ccaat-enhancer-binding-protein-homologous-protein-chop-prevents-diet-induced-aortic-valve-calcification-in%C3%A2-vivo
#13
Zhejun Cai, Baoqing Liu, Jia Wei, Zurong Fu, Yidong Wang, Yaping Wang, Jian Shen, Liangliang Jia, Shengan Su, Xiaoya Wang, Xiaoping Lin, Han Chen, Fei Li, Jian'an Wang, Meixiang Xiang
Aortic valve (AoV) calcification is common in aged populations. Its subsequent aortic stenosis has been linked with increased morbidity, but still has no effective pharmacological intervention. Our previous data show endoplasmic reticulum (ER) stress is involved in AoV calcification. Here, we investigated whether deficiency of ER stress downstream effector CCAAT/enhancer-binding protein homology protein (CHOP) may prevent development of AoV calcification. AoV calcification was evaluated in Apoe(-/-) mice (n = 10) or in mice with dual deficiencies of ApoE and CHOP (Apoe(-/-) CHOP(-/-) , n = 10) fed with Western diet for 24 weeks...
September 10, 2017: Aging Cell
https://www.readbyqxmd.com/read/28890346/hepatoprotective-effects-of-methyl-ferulic-acid-on-alcohol-induced-liver-oxidative-injury-in-mice-by-inhibiting-the-nox4-ros-mapk-pathway
#14
Chen Li, Li Li, Cheng-Fang Yang, Yu-Juan Zhong, Dan Wu, Lin Shi, Li Chen, Yong-Wen Li
AIMS: The present study aimed to investigate the hepatoprotective effects of Methyl ferulic acid (MFA) against oxidative stress and apoptosis as well as inflammation in mice with liver injury induced by alcohol and its underlying mechanisms. METHODS: C57BL/6 mice were divided into a control group,a model group, and Methyl ferulic acid with high dosage (20 mg/kg), moderate dosage (10 mg/kg) and low dosage (5 mg/kg) groups. The general condition and organ index of each group were investigated...
September 7, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28888470/functional-and-biochemical-adaptations-of-elite-level-futsal-players-from-brazil-along-a-training-season
#15
Rômulo Pillon Barcelos, Guilherme Lopes Tocchetto, Frederico Diniz Lima, Sílvio Terra Stefanello, Harrison Fabricio Muzzy Rodrigues, Manuela Borges Sangoi, Rafael Noal Moresco, Luiz Fernando Freire Royes, Félix Alexandre Antunes Soares, Guilherme Bresciani
BACKGROUND AND OBJECTIVE: Although hard training is mandatory in elite level futsal training, few studies have proposed a biochemical follow up in futsal players during a whole season. Therefore, the aim of this study was to compare functional and biochemical markers in Brazilian elite level futsal players throughout a competition season. MATERIALS AND METHODS: Eight players aged 25.5±5.4 years were evaluated at three time points: preseason (T1), immediately before the FIFA(®)-Intercontinental-Futsal-Cup (T2), and at the end of the season (T3), with a tapering period of 1 week before T2...
August 26, 2017: Medicina
https://www.readbyqxmd.com/read/28888077/microrna-214-3p-a-link-between-autophagy-and-endothelial-cell-dysfunction-in-atherosclerosis
#16
Jing Wang, Wei-Na Wang, Shuang-Bin Xu, Hong Wu, Bing Dai, Dong-Dong Jian, Mei Yang, Yu-Tao Wu, Qiang Feng, Jian-Hua Zhu, Lei Zhang, Li Zhang
AIM: Endothelial cell injury assumes a fundamental part in the pathogenesis of atherosclerosis, and endothelial cell autophagy has protective effects on the development of atherosclerosis, though the underlying molecular regulation mechanism is indistinct. This study is aimed to investigate whether microRNA-214-3p (miR-214-3p) is involved in the endothelial cell autophagy regulation of atherosclerosis. METHODS: We utilized ApoE-/- mice provided with a high-fat diet (HFD) as atherosclerosis model...
September 9, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28883884/itraq-based-quantitative-proteomics-analysis-of-the-protective-effect-of-yinchenwuling-powder-on-hyperlipidemic-rats
#17
Zheyu Zhang, Wenbo Wang, Ling Jin, Xin Cao, Gonghui Jian, Ning Wu, Xia Xu, Ye Yao, Dongsheng Wang
Yinchenwuling powder (YCL) is an effective traditional Chinese medicine formula to modulate lipid levels. In this study, we established hyperlipidemic rat models and treated them with YCL. The serum concentrations of lipid, malondialdehyde (MDA), endothelin-1 (ET-1), and calcitonin gene-related peptide (CGRP) were measured. Adventitia-free vascular proteins between hyperlipidemic rats and YCL-treated rats were identified using iTRAQ-based quantitative proteomics research approach. Proteins with 1.3-fold difference were analyzed through bioinformatics, and proteomic results were verified by Western blot...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28883612/human-electronegative-low-density-lipoprotein-modulates-cardiac-repolarization-via-lox-1-mediated-alteration-of-sarcolemmal-ion-channels
#18
An-Sheng Lee, Yutao Xi, Chin-Hu Lai, Wei-Yu Chen, Hsien-Yu Peng, Hua-Chen Chan, Chu-Huang Chen, Kuan-Cheng Chang
Dyslipidemia is associated with greater risk of ventricular tachyarrhythmias in patients with cardiovascular diseases. We aimed to examine whether the most electronegative subfraction of low-density lipoprotein (LDL), L5, is correlated with QTc prolongation in patients with coronary artery disease (CAD) and investigate the effects of human L5 on the electrophysiological properties of cardiomyocytes in relation to the lectin-like oxidized LDL receptor (LOX-1). L5 was isolated from the plasma of 40 patients with angiography documented CAD and 13 patients with no CAD to correlate the QTc interval respectively...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28882869/extracellular-vesicles-secreted-by-atherogenic-macrophages-transfer-microrna-to-inhibit-cell-migration
#19
My-Anh Nguyen, Denuja Karunakaran, Michele Geoffrion, Henry S Cheng, Kristofferson Tandoc, Ljubica Perisic Matic, Ulf Hedin, Lars Maegdefessel, Jason E Fish, Katey J Rayner
OBJECTIVE: During inflammation, macrophages secrete vesicles carrying RNA, protein, and lipids as a form of extracellular communication. In the vessel wall, extracellular vesicles (EVs) have been shown to be transferred between vascular cells during atherosclerosis; however, the role of macrophage-derived EVs in atherogenesis is not known. Here, we hypothesize that atherogenic macrophages secrete microRNAs (miRNAs) in EVs to mediate cell-cell communication and promote proinflammatory and proatherogenic phenotypes in recipient cells...
September 7, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28880900/phase-separation-of-the-plasma-membrane-in-human-red-blood-cells-as-a-potential-tool-for-diagnosis-and-progression-monitoring-of-type-1-diabetes-mellitus
#20
Giuseppe Maulucci, Ermanno Cordelli, Alessandro Rizzi, Francesca De Leva, Massimiliano Papi, Gabriele Ciasca, Daniela Samengo, Giovambattista Pani, Dario Pitocco, Paolo Soda, Giovanni Ghirlanda, Giulio Iannello, Marco De Spirito
Glycosylation, oxidation and other post-translational modifications of membrane and transmembrane proteins can alter lipid density, packing and interactions, and are considered an important factor that affects fluidity variation in membranes. Red blood cells (RBC) membrane physical state, showing pronounced alterations in Type 1 diabetes mellitus (T1DM), could be the ideal candidate for monitoring the disease progression and the effects of therapies. On these grounds, the measurement of RBC membrane fluidity alterations can furnish a more sensitive index in T1DM diagnosis and disease progression than Glycosylated hemoglobin (HbA1c), which reflects only the information related to glycosylation processes...
2017: PloS One
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