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https://www.readbyqxmd.com/read/28193239/buformin-inhibits-the-stemness-of-erbb-2-overexpressing-breast-cancer-cells-and-premalignant-mammary-tissues-of-mmtv-erbb-2-transgenic-mice
#1
Amanda B Parris, Qingxia Zhao, Erin W Howard, Ming Zhao, Zhikun Ma, Xiaohe Yang
BACKGROUND: Metformin, an FDA-approved drug for the treatment of Type II diabetes, has emerged as a promising anti-cancer agent. Other biguanide analogs, including buformin and phenformin, are suggested to have similar properties. Although buformin was shown to reduce mammary tumor burden in carcinogen models, the anti-cancer effects of buformin on different breast cancer subtypes and the underlying mechanisms remain unclear. Therefore, we aimed to investigate the effects of buformin on erbB-2-overexpressing breast cancer with in vitro and in vivo models...
February 13, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/28188186/nccn-guidelines-insights-bone-cancer-version-2-2017
#2
J Sybil Biermann, Warren Chow, Damon R Reed, David Lucas, Douglas R Adkins, Mark Agulnik, Robert S Benjamin, Brian Brigman, G Thomas Budd, William T Curry, Aarati Didwania, Nicola Fabbri, Francis J Hornicek, Joseph B Kuechle, Dieter Lindskog, Joel Mayerson, Sean V McGarry, Lynn Million, Carol D Morris, Sujana Movva, Richard J O'Donnell, R Lor Randall, Peter Rose, Victor M Santana, Robert L Satcher, Herbert Schwartz, Herrick J Siegel, Katherine Thornton, Victor Villalobos, Mary Anne Bergman, Jillian L Scavone
The NCCN Guidelines for Bone Cancer provide interdisciplinary recommendations for treating chordoma, chondrosarcoma, giant cell tumor of bone, Ewing sarcoma, and osteosarcoma. These NCCN Guidelines Insights summarize the NCCN Bone Cancer Panel's guideline recommendations for treating Ewing sarcoma. The data underlying these treatment recommendations are also discussed.
February 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/28183697/safety-and-antitumor-activity-of-the-multi-targeted-pan-trk-ros1-and-alk-inhibitor-entrectinib-rxdx-101-combined-results-from-two-phase-1-trials-alka-372-001-and-startrk-1
#3
Alexander Drilon, Salvatore Siena, Sai-Hong Ignatius Ou, Manish Patel, Myung Ju Ahn, Jeeyun Lee, Todd M Bauer, Anna F Farago, Jennifer J Wheler, Stephen V Liu, Robert Doebele, Laura Giannetta, Giulio Cerea, Giovanna Marrapese, Michele Schirru, Alessio Amatu, Katia Bencardino, Laura Palmeri, Andrea Sartore-Bianchi, Angelo Vanzulli, Sara Cresta, Silvia Damian, Matteo Duca, Elena Ardini, Gang Li, Jason Christiansen, Karey Kowalski, Ann Johnson, Rupal Patel, David Luo, Edna Chow-Maneval, Zachary Hornby, Pratik S Multani, Alice T Shaw, Filippo G De Braud
Entrectinib, a potent oral inhibitor of the tyrosine kinases TRKA/B/C, ROS1, and ALK, was evaluated in two Phase 1 studies in patients with advanced or metastatic solid tumors, including patients with active CNS disease. Here we summarize the overall safety and report the antitumor activity of entrectinib in a cohort of patients with tumors harboring NTRK1/2/3, ROS1, or ALK gene fusions, naïve to prior TKI treatment targeting the specific gene, and who were treated at doses that achieved therapeutic exposures consistent with the RP2D...
February 9, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28183304/genistein-treatment-improves-fracture-resistance-in-obese-diabetic-mice
#4
Britton Odle, Nathan Dennison, Layla Al-Nakkash, Tom L Broderick, Jeffrey H Plochocki
BACKGROUND: Obese, type two diabetics are at an increased risk for fracturing their limb bones in comparison to the general population. Phytoestrogens like as the soy isoflavone genistein have been shown to protect against bone loss. In this study, we tested the effects of genistein treatment on femurs of ob/ob mice, a model for obesity and type two diabetes mellitus. METHODS: Twenty six-week-old female mice were divided into obese (ob/ob) control, obese genistein-treated, lean (ob/+) control, and lean genistein-treated groups (n = 5 each)...
January 9, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28183295/meta-analysis-of-gene-expression-in-relapsed-childhood-b-acute-lymphoblastic-leukemia
#5
Yock-Ping Chow, Hamidah Alias, Rahman Jamal
BACKGROUND: Relapsed pediatric B-acute lymphoblastic leukemia (B-ALL) remains as the leading cause of cancer death among children. Other than stem cell transplantation and intensified chemotherapy, no other improved treatment strategies have been approved clinically. Gene expression profiling represents a powerful approach to identify potential biomarkers and new therapeutic targets for various diseases including leukemias. However, inadequate sample size in many individual experiments has failed to provide adequate study power to yield translatable findings...
February 10, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28182596/the-dawn-of-transparency-insights-from-the-physician-payment-sunshine-act-in-plastic-surgery
#6
Rizwan Ahmed, Joseph Lopez, Sunjae Bae, Allan B Massie, Eric K Chow, Karan Chopra, Babak J Orandi, Bonnie E Lonze, James W May, Justin M Sacks, Dorry L Segev
BACKGROUND: The Physician Payments Sunshine Act (PSSA) is a government initiative that requires all biomedical companies to publicly disclose payments to physicians through the Open Payments Program (OPP). The goal of this study was to use the OPP database and evaluate all nonresearch-related financial transactions between plastic surgeons and biomedical companies. METHODS: Using the first wave of OPP data published on September 30, 2014, we studied the national distribution of industry payments made to plastic surgeons during a 5-month period...
March 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28179104/variations-in-structure-of-the-outflow-tract-of-the-human-embryonic-heart-a-new-hypothesis-for-generating-bicuspid-aortic-semilunar-valves
#7
Nadine C Milos, Derek B Nordstrom, Ivano Ongaro, Ava K Chow
Outflow tract development of the heart is complex. The presence, differential growth and interactions of the various tissues through space and time contribute to the final development of the tract. This paper presents a novel interpretation of observations of outflow tract development, in particular of the aortic and pulmonary semilunar valves in embryos from the Shaner Collection at the University of Alberta. Three-dimensional reconstructions assist in the visualization of the spatial relationships of the developing valve tissues...
February 4, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/28177981/high-fat-diet-alters-weight-caloric-intake-and-haloperidol-sensitivity-in-the-context-of-effort-based-responding
#8
Stephen H Robertson, Steven R Boomhower, Erin B Rasmussen
High-fat (HF) diets result in weight gain, hyperphagia, and reduced dopamine D2 signaling; however, these findings have been obtained only under free-feeding conditions. This study tested the extent to which HF diet affects effort-dependent food procurement and the extent to which dopamine signaling is involved. Male Sprague-Dawley rats consumed either a HF (n=20) or a standard-chow (n=20) diet. We assessed the sensitivity to effort-based reinforcement in 10 rats from each group by measuring consumption across a series of fixed-ratio schedules (FR 5-FR 300) under a closed economy and quantified performance using the exponential-demand equation...
February 7, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/28169509/nonalcoholic-fatty-liver-disease-and-measures-of-early-brain-health-in-middle-aged-adults-the-cardia-study
#9
Lisa B VanWagner, James G Terry, Lisa S Chow, Amy C Alman, Hakmook Kang, Katherine H Ingram, Christina Shay, Cora E Lewis, R Nick Bryan, Lenore J Launer, J Jeffrey Carr
OBJECTIVE: To assess associations between nonalcoholic fatty liver disease (NAFLD) and measures of brain health in a population-based sample of adults. METHODS: Participants from the CARDIA study (Y25 exam; age 43-55 years) with concurrent computed tomography quantification of liver fat, visceral adipose tissue (VAT), and brain magnetic resonance (MR) images were included (n = 505). NAFLD was identified after exclusion of other causes of liver fat. Total tissue volume (TTV) and gray matter cerebral blood flow (GM-CBF) were estimated using 3T brain MR images...
February 7, 2017: Obesity
https://www.readbyqxmd.com/read/28163959/kolaviron-a-biflavonoid-of-garcinia-kola-seed-mitigates-ischemic-reperfusion-injury-by-modulation-of-pro-survival-and-apoptotic-signaling-pathways
#10
Ademola Adetokunbo Oyagbemi, Dirk Bester, Johan Esterhuyse, Ebenezer Olatunde Farombi
OBJECTIVE: The study was designed to investigate the ameliorative effect of Kolaviron (KV) on ischemic/reperfusion injury in experimental animal models. MATERIALS AND METHODS: Male Wistar rats were randomly divided into two groups: Group 1 received corn oil as a vehicle and rats in Group 2 were administered KV at 200 mg/kg for 4 weeks. The rats were fed with rat standard chow pellet and water administered ad libitum. After 4 weeks of KV administration, hearts were excised and mounted on the working heart perfusion system...
January 2017: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/28148207/clinical-cancer-advances-2017-annual-report-on-progress-against-cancer-from-the-american-society-of-clinical-oncology
#11
Harold J Burstein, Lada Krilov, Jeanny B Aragon-Ching, Nancy N Baxter, E Gabriela Chiorean, Warren Allen Chow, John Frederick De Groot, Steven Michael Devine, Steven G DuBois, Wafik S El-Deiry, Andrew S Epstein, John Heymach, Joshua Adam Jones, Deborah K Mayer, Rebecca A Miksad, Nathan A Pennell, Michael S Sabel, Richard L Schilsky, Lynn Mara Schuchter, Nadine Tung, Karen Marie Winkfield, Lori J Wirth, Don S Dizon
A MESSAGE FROM ASCO'S PRESIDENT I am pleased to present Clinical Cancer Advances 2017, which highlights the most promising advances in patient-oriented cancer research over the past year. The report gives us an opportunity to reflect on what an exciting time it is for cancer research and how swiftly our understanding of cancer has improved. One year ago, the White House announced the national Cancer Moonshot program to accelerate progress against cancer. This shared vision of progress has reinvigorated the research community, identified new areas of scientific collaboration, and raised our ambitions regarding what may be possible beyond the progress we have already made...
February 1, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28137737/evidence-for-the-founder-effect-of-ret533-as-the-common-greek-and-brazilian-ancestor-spreading-multiple-endocrine-neoplasia-2a
#12
Lucas Leite Cunha, Susan Chow Lindsey, Maria Inez França, Leda Sarika, Alexandra Papathoma, Ilda S Kunii, Janete Maria Cerutti, Magnus R Dias-da-Silva, Maria Alevizaki, Rui M B Maciel
OBJECTIVES: About one quarter of patients with medullary thyroid cancer (MTC) have inherited disease due to mutations in the RET gene. A rare mutation in exon 8 (G533C) of RET, previously described in a large Brazilian family with MEN2A, appeared to be clustering also in Greece while it was rarely reported in other ethnic groups. The aim of this study was to identify a possible common ancestry between these carriers. PATIENTS AND METHODS: Twelve RET G533C mutation carriers, four randomly selected from the Brazilian cohort and eight from apparently unrelated Greek families, were studied for a possible common ancestral origin...
January 30, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28137427/hypercaloric-diet-prevents-sexual-impairment-induced-by-maternal-food-restriction
#13
M M Bernardi, D J Macrini, E Teodorov, L V Bonamin, L C Dalboni, C P Coelho, G P Chaves-Kirsten, J C Florio, N Queiroz-Hazarbassanov, E F Bondan, T B Kirsten
Prenatal undernutrition impairs copulatory behavior and increases the tendency to become obese/overweight, which also reduces sexual behavior. Re-feeding rats prenatally undernourished with a normocaloric diet can restore their physiological conditions and copulatory behavior. Thus, the present study investigated whether a hypercaloric diet that is administered in rats during the juvenile period prevents sexual impairments that are caused by maternal food restriction and the tendency to become overweight/obese...
January 28, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28131576/bovine-milk-oligosaccharides-decrease-gut-permeability-and-improve-inflammation-and-microbial-dysbiosis-in-diet-induced-obese-mice
#14
Gaëlle Boudry, M Kristina Hamilton, Maciej Chichlowski, Saumya Wickramasinghe, Daniela Barile, Karen M Kalanetra, David A Mills, Helen E Raybould
Obesity is characterized by altered gut homeostasis, including dysbiosis and increased gut permeability closely linked to the development of metabolic disorders. Milk oligosaccharides are complex sugars that selectively enhance the growth of specific beneficial bacteria in the gastrointestinal tract and could be used as prebiotics. The aim of the study was to demonstrate the effects of bovine milk oligosaccharides (BMO) and Bifidobacterium longum ssp. infantis (B. infantis) on restoring diet-induced obesity intestinal microbiota and barrier function defects in mice...
January 25, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28119186/phytosterols-isolated-from-clinacanthus-nutans-induce-immunosuppressive-activity-in-murine-cells
#15
Cheng-Foh Le, Thina Hareesh Kailaivasan, Sek-Chuen Chow, Zunoliza Abdullah, Sui-Kiong Ling, Chee-Mun Fang
Clinacanthus nutans (Burm. f.) Lindau is a traditional medicinal plant belonging to the Acanthaceae family. Its therapeutic potentials have been increasingly documented particularly the antiviral activity against Herpes Simplex Virus (HSV), anti-cancer, anti-oxidant, anti-inflammatory and immunomodulatory activities. However, majority of these studies used crude or fractionated extracts and not much is known about individual compounds from these extracts and their biological activities. In the present study, we have isolated four compounds (CN1, CN2, CN3 and CN4) from the hexane fractions of C...
January 21, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28118019/nonpolar-ingan-gan-core-shell-single-nanowire-lasers
#16
Changyi Li, Jeremy B Wright, Sheng Liu, Ping Lu, Jeffrey J Figiel, Benjamin Leung, Weng W Chow, Igal Brener, Daniel D Koleske, Ting-Shan Luk, Daniel F Feezell, S R J Brueck, George T Wang
We report lasing from nonpolar p-i-n InGaN/GaN multi-quantum well core-shell single-nanowire lasers by optical pumping at room temperature. The nanowire lasers were fabricated using a hybrid approach consisting of a top-down two-step etch process followed by a bottom-up regrowth process, enabling precise geometrical control and high material gain and optical confinement. The modal gain spectra and the gain curves of the core-shell nanowire lasers were measured using micro-photoluminescence and analyzed using the Hakki-Paoli method...
January 24, 2017: Nano Letters
https://www.readbyqxmd.com/read/28105518/associations-between-hepatic-mirna-expression-liver-triacylglycerols-and-gut-microbiota-during-metabolic-adaptation-to-high-fat-diet-in-mice
#17
Vincent Blasco-Baque, Berengère Coupé, Aurelie Fabre, Sandra Handgraaf, Pierre Gourdy, Jean-François Arnal, Michael Courtney, Carole Schuster-Klein, Beatrice Guardiola, François Tercé, Rémy Burcelin, Matteo Serino
AIMS/HYPOTHESIS: Despite the current pandemic of metabolic diseases, our understanding of the diverse nature of the development of metabolic alterations in people who eat a high-fat diet (HFD) is still poor. We recently demonstrated a cardio-metabolic adaptation in mice fed an HFD, which was characterised by a specific gut and periodontal microbiota profile. Since the severity of hepatic disease is characterised by specific microRNA (miRNA) signatures and the gut microbiota is a key driver of both hepatic disease and miRNA expression, we analysed the expression of three hepatic miRNA and studied their correlation with hepatic triacylglycerol content and gut microbiota...
January 19, 2017: Diabetologia
https://www.readbyqxmd.com/read/28104916/trpv1-activation-counters-diet-induced-obesity-through-sirtuin-1-activation-and-prdm-16-deacetylation-in-brown-adipose-tissue
#18
P Baskaran, V Krishnan, K Fettel, P Gao, Z Zhu, J Ren, B Thyagarajan
BACKGROUND/OBJECTIVE: An imbalance between energy intake and expenditure leads to obesity. Increasing metabolism and thermogenesis in brown adipose tissue (BAT) can help in overcoming obesity. Here, we investigated the effect of activation of transient receptor potential vanilloid subfamily 1 (TRPV1) in the upregulation of thermogenic proteins in BAT to counter diet-induced obesity. SUBJECTS/METHODS: We investigated the effect of dietary supplementation of capsaicin (TRPV1 agonist) on the expression of metabolically important thermogenic proteins in BAT of wild type and TRPV1(-/-) mice that received either a normal chow or high fat (±capsaicin; TRPV1 activator) diet by immunoblotting...
January 20, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28101339/pre-treatment-with-simvastatin-prevents-the-induction-of-diet-induced-atherosclerosis-in-a-rabbit-model
#19
Nikolaos Oikonomidis, Nikolaos Kavantzas, Laskarina-Maria Korou, Panagiotis Konstantopoulos, Vasilios Pergialiotis, Evangelos Misiakos, Ioannis Rizos, Christos Verikokos, Despina N Perrea
The aim of the present study was to investigate the potential antiatherosclerotic activities of simvastatin in rabbits. Twenty-two, male, New Zealand rabbits were divided into the following groups: Control group (group C); cholesterol group (group A), in which the rabbits were fed a commercial rabbit chow supplemented with 0.5% w/w cholesterol for 8 weeks and then fed with normal chow for an additional 8 weeks; and a treatment group (group B), in which the rabbits initially received standard commercial rabbit chow along with being administered simvastatin for 8 weeks, following which they consumed a high-cholesterol diet for a further 8 weeks...
December 2016: Biomedical Reports
https://www.readbyqxmd.com/read/28100822/conditional-fetal-and-infant-killing-by-male-baboons
#20
Matthew N Zipple, Jackson H Grady, Jacob B Gordon, Lydia D Chow, Elizabeth A Archie, Jeanne Altmann, Susan C Alberts
Sexually selected feticide-the death of infants in utero as a result of male behaviour-has only rarely been described or analysed, although it is presumed to be favoured by the same selective pressures that favour sexually selected infanticide. To test this hypothesis, we measured the frequency of feticide and infanticide by male baboons of the Amboseli basin in Kenya, and examined which characteristics of a male and his environment made him more likely to commit feticide and/or infanticide. We found a dramatic increase in fetal and infant death rates, but no increase in death rates of 1- to 2-year-old individuals, following the immigration of males who stood to benefit from feticide and infanticide...
January 25, 2017: Proceedings. Biological Sciences
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