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https://www.readbyqxmd.com/read/27908677/haemodynamic-variations-of-flow-to-renal-arteries-in-custom-made-and-pivot-branch-fenestrated-endografting
#1
J Ou, A Y S Tang, T L Chiu, K W Chow, Y C Chan, S W K Cheng
OBJECTIVE: This study aimed to investigate variation of blood flow to renal arteries in custom-made and pivot branch (p-branch) fenestrated endografting, using a computational fluid dynamics (CFD) technique. METHODS: Idealised models of custom-made and p-branch fenestrated grafting were constructed on a basis of a 26 mm stent graft. The custom-made fenestration was designed with a 6 mm diameter, while the 5 mm depth renal p-branch was created with a 6 mm inner and 15 mm outer fenestration...
November 28, 2016: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/27899805/circulating-tumour-dna-analysis-demonstrates-spatial-mutational-heterogeneity-that-coincides-with-disease-relapse-in-myeloma
#2
S Mithraprabhu, T Khong, M Ramachandran, A Chow, D Klarica, L Mai, S Walsh, D Broemeling, A Marziali, M Wiggin, J Hocking, A Kalff, B Durie, A Spencer
Mutational characterisation in multiple myeloma (MM) currently relies on bone marrow (BM) biopsy, which fails to capture the putative spatial and genetic heterogeneity of this multi-focal disease. Analysis of plasma (PL)-derived circulating free tumour DNA (ctDNA) as an adjunct to BM biopsy, for mutational characterisation and tracking disease progression, was evaluated. Paired BM MM cell DNA and ctDNA from 33 relapsed [RR] and 15 newly diagnosed [ND] patients were analysed for KRAS, NRAS, BRAF and TP53 mutations using the OnTarget™ Mutation Detection (OMD) platform...
November 30, 2016: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/27899343/long-term-high-fat-diet-induces-hippocampal-microvascular-insulin-resistance-and-cognitive-dysfunction
#3
Zhuo Fu, Jing Wu, Tanseli Nesil, Ming D Li, Kevin W Aylor, Zhenqi Liu
Insulin action on hippocampus improves cognitive function and obesity and type 2 diabetes are associated with decreased cognitive function. Cerebral microvasculature plays a critical role in maintaining cerebral vitality and function by supplying nutrients, oxygen and hormones such as insulin to cerebral parenchyma including hippocampus. In skeletal muscle insulin actively regulates microvascular opening and closure and this action is impaired in the insulin resistant states. To examine insulin's action on hippocampal microvasculature and parenchyma and the impact of diet-induced obesity we determined cognitive function, and microvascular insulin responses, parenchyma insulin responses and capillary density in the hippocampus in 2-month and 8-month rats on chow diet and 8-month rats on long-term high-fat diet (6 months)...
November 29, 2016: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27893662/the-transcriptomic-g1-g6-signature-of-hepatocellular-carcinoma-in-an-asian-population-association-of-g3-with-microvascular-invasion
#4
John Carson Allen, Jean-Charles Nault, Guili Zhu, Andrew Yu Keat Khor, Jin Liu, Tony Kiat Hon Lim, Jessica Zucman-Rossi, Pierce K H Chow
In this study, a transcriptomic group classification based on a European population is tested on a Singapore cohort. The results highlight the genotype/phenotype correlation in a Southeast Asian population. The G1-G6 transcriptomic classification derived from hepatocellular carcinoma (HCC) resected from European patients, robustly reflected group-specific clinical/pathological features. We investigated the application of this molecular classification in Southeast Asian HCC patients.Gene expression analysis was carried out on HCC surgically resected in Singapore patients who were grouped into G1-G6 transcriptomic categories according to expression of 16 predictor genes (illustrated in Supplementary Table 1, http://links...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27893331/multidisciplinary-approach-to-novel-therapies-in-cardio-oncology-research-manticore-101-breast-a-randomized-trial-for-the-prevention-of-trastuzumab-associated-cardiotoxicity
#5
Edith Pituskin, John R Mackey, Sheri Koshman, Davinder Jassal, Marshall Pitz, Mark J Haykowsky, Joseph J Pagano, Kelvin Chow, Richard B Thompson, Larissa J Vos, Sunita Ghosh, Gavin Y Oudit, Justin A Ezekowitz, D Ian Paterson
Purpose The primary toxicity of trastuzumab therapy for human epidermal growth factor receptor 2-overexpressing (HER2-positive) breast cancer is dose-independent cardiac dysfunction. Angiotensin-converting enzyme inhibitors and β-blockers are recommended first-line agents for heart failure. We hypothesized that angiotensin-converting enzyme inhibitors and β-blockers could prevent trastuzumab-related cardiotoxicity. Patients and Methods In this double-blinded, placebo-controlled trial, patients with HER2-positive early breast cancer were randomly assigned to receive treatment with perindopril, bisoprolol, or placebo (1:1:1) for the duration of trastuzumab adjuvant therapy...
November 28, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27892487/female-gender-lost-protective-effect-against-disease-progression-in-elderly-patients-with-chronic-hepatitis-b
#6
Hong You, Yuanyuan Kong, Jinlin Hou, Lai Wei, Yuexin Zhang, Junqi Niu, Tao Han, Xiaojuan Ou, Xiaoguang Dou, Jia Shang, Hong Tang, Qing Xie, Huiguo Ding, Hong Ren, Xiaoyuan Xu, Wen Xie, Xiaoqing Liu, Youqing Xu, Yujie Li, Jie Li, Shein-Chung Chow, Hui Zhuang, Jidong Jia
Female gender and younger age are protective factors against disease progression in chronic hepatitis B (CHB). However, it is not clear whether the disease progression still remains slow in elderly females. This study investigated the interaction of female gender and older age on the development of cirrhosis in patients recorded in China Registry of Hepatitis B. A total of 17,809 CHB patients were enrolled in this multi-center cross-sectional study. The prevalence of cirrhosis in female CHB patients increased faster than that in male CHB patients over 50 years old...
November 28, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27889120/comparison-of-commercial-dna-extraction-kits-and-quantitative-pcr-systems-for-better-sensitivity-in-detecting-the-causative-agent-of-paratuberculosis-in-dairy-cow-fecal-samples
#7
D Fock-Chow-Tho, E Topp, E A Ibeagha-Awemu, N Bissonnette
Mycobacterium avium ssp. paratuberculosis (MAP) causes ruminant paratuberculosis (Johne's disease) worldwide. Oral-fecal contamination is the most important mode of transmission of paratuberculosis, so eradicating MAP-shedding animals could prevent disease propagation. Fecal culture, a well-known method for MAP diagnosis, requires costly specialized media and a long incubation time that sometimes ends in disappointing bacterial contamination. To facilitate the efforts of control programs, we evaluated the performance of direct fecal quantitative PCR (qPCR) assays for their sensitivity and robustness for MAP detection...
November 23, 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27869821/synthetic-recording-and-in-situ-readout-of-lineage-information-in-single-cells
#8
Kirsten L Frieda, James M Linton, Sahand Hormoz, Joonhyuk Choi, Ke-Huan K Chow, Zakary S Singer, Mark W Budde, Michael B Elowitz, Long Cai
Reconstructing the lineage relationships and dynamic event histories of individual cells within their native spatial context is a long-standing challenge in biology. Many biological processes of interest occur in optically opaque or physically inaccessible contexts, necessitating approaches other than direct imaging. Here, we describe a new synthetic system that enables cells to record lineage information and event histories in the genome in a format that can be subsequently read out in single cells in situ...
November 21, 2016: Nature
https://www.readbyqxmd.com/read/27869178/importance-of-the-c-terminal-histidine-residues-of-helicobacter-pylori-groes-for-toll-like-receptor-4-binding-and-interleukin-8-cytokine-production
#9
Haur Lee, Yu-Lin Su, Bo-Shih Huang, Feng-Tse Hsieh, Ya-Hui Chang, Shiou-Ru Tzeng, Chun-Hua Hsu, Po-Tsang Huang, Kuo-Long Lou, Yeng-Tseng Wang, Lu-Ping Chow
Helicobacter pylori infection is associated with the development of gastric and duodenal ulcers as well as gastric cancer. GroES of H. pylori (HpGroES) was previously identified as a gastric cancer-associated virulence factor. Our group showed that HpGroES induces interleukin-8 (IL-8) cytokine release via a Toll-like receptor 4 (TLR4)-dependent mechanism and domain B of the protein is crucial for interactions with TLR4. In the present study, we investigated the importance of the histidine residues in domain B...
November 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27856454/endothelial-cell-specific-deletion-of-p2y2-receptor-promotes-plaque-stability-in-atherosclerosis-susceptible-apoe-null-mice
#10
Chen Xingjuan, Shaomin Qian, April Hoggatt, Hongying Tang, Timothy A Hacker, Alexander G Obukhov, Paul B Herring, Cheikh I Seye
OBJECTIVE: Nucleotide P2Y2 receptor (P2Y2R) contributes to vascular inflammation by increasing vascular cell adhesion molecule-1 expression in endothelial cells (EC), and global P2Y2R deficiency prevents fatty streak formation in apolipoprotein E null (ApoE(-/-)) mice. Because P2Y2R is ubiquitously expressed in vascular cells, we investigated the contribution of endothelial P2Y2R in the pathogenesis of atherosclerosis. APPROACH AND RESULTS: EC-specific P2Y2R-deficient mice were generated by breeding VEcadherin5-Cre mice with the P2Y2R floxed mice...
November 17, 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/27852672/a-novel-selective-medium-for-isolation-of-bacteroides-fragilis-from-clinical-specimens
#11
Pak-Leung Ho, Lok-Yan Ho, Chong-Yee Yau, Man-Ki Tong, Kin-Hung Chow
A novel Bacteroides fragilis selective (BFS) medium, consisting of a brain-heart infusion agar base supplemented with yeast extract, cysteine hydrochloride, bile salts, Vitamin K, hemin, glucose, esculin, ferric ammonium citrate, bromothymol blue, gentamicin, kanamycin and novobiocin, was evaluated. When BFS agar was tested with a collection of 303 bacteria of different genera, it allowed the growth of B. fragilis as large yellow colonies with blackening of the medium after 48 h of anaerobic incubation while the growth of most other anaerobes, facultative anaerobes and aerobes were inhibited...
November 16, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27852011/a-new-chicken-genome-assembly-provides-insight-into-avian-genome-structure
#12
Wesley C Warren, LaDeana W Hillier, Chad Tomlinson, Patrick Minx, Milinn Kremitzki, Tina Graves, Chris Markovic, Nathan Bouk, Kim D Pruitt, Francoise Thibaud-Nissen, Valerie Schneider, Tamer A Mansour, C Titus Brown, Aleksey Zimin, Rachel Hawken, Mitch Abrahamsen, Alexis B Pyrkosz, Mireille Morisson, Valerie Fillon, Alain Vignal, William Chow, Kerstin Howe, Janet E Fulton, Marcia M Miller, Peter Lovell, Claudio V Mello, Morgan Wirthlin, Andrew S Mason, Richard Kuo, David W Burt, Jerry B Dodgson, Hans H Cheng
The importance of the Gallus gallus (chicken) as a model organism and agricultural animal merits a continuation of sequence assembly improvement efforts. We present a new version of the chicken genome assembly (Gallus_gallus-5.0; GCA_000002315.3) built from combined long single molecule sequencing technology, finished BACs, and improved physical maps. In overall assembled bases, we see a gain of 183 Mb including 16.4 Mb in placed chromosomes with a corresponding gain in the percentage of intact repeat elements characterized...
November 14, 2016: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/27834993/measurement-of-the-inelastic-proton-proton-cross-section-at-sqrt-s-13%C3%A2-%C3%A2-tev-with-the-atlas-detector-at-the-lhc
#13
M Aaboud, G Aad, B Abbott, J Abdallah, O Abdinov, B Abeloos, R Aben, O S AbouZeid, N L Abraham, H Abramowicz, H Abreu, R Abreu, Y Abulaiti, B S Acharya, L Adamczyk, D L Adams, J Adelman, S Adomeit, T Adye, A A Affolder, T Agatonovic-Jovin, J Agricola, J A Aguilar-Saavedra, S P Ahlen, F Ahmadov, G Aielli, H Akerstedt, T P A Åkesson, A V Akimov, G L Alberghi, J Albert, S Albrand, M J Alconada Verzini, M Aleksa, I N Aleksandrov, C Alexa, G Alexander, T Alexopoulos, M Alhroob, B Ali, M Aliev, G Alimonti, J Alison, S P Alkire, B M M Allbrooke, B W Allen, P P Allport, A Aloisio, A Alonso, F Alonso, C Alpigiani, M Alstaty, B Alvarez Gonzalez, D Álvarez Piqueras, M G Alviggi, B T Amadio, K Amako, Y Amaral Coutinho, C Amelung, D Amidei, S P Amor Dos Santos, A Amorim, S Amoroso, G Amundsen, C Anastopoulos, L S Ancu, N Andari, T Andeen, C F Anders, G Anders, J K Anders, K J Anderson, A Andreazza, V Andrei, S Angelidakis, I Angelozzi, P Anger, A Angerami, F Anghinolfi, A V Anisenkov, N Anjos, A Annovi, C Antel, M Antonelli, A Antonov, F Anulli, M Aoki, L Aperio Bella, G Arabidze, Y Arai, J P Araque, A T H Arce, F A Arduh, J-F Arguin, S Argyropoulos, M Arik, A J Armbruster, L J Armitage, O Arnaez, H Arnold, M Arratia, O Arslan, A Artamonov, G Artoni, S Artz, S Asai, N Asbah, A Ashkenazi, B Åsman, L Asquith, K Assamagan, R Astalos, M Atkinson, N B Atlay, K Augsten, G Avolio, B Axen, M K Ayoub, G Azuelos, M A Baak, A E Baas, M J Baca, H Bachacou, K Bachas, M Backes, M Backhaus, P Bagiacchi, P Bagnaia, Y Bai, J T Baines, O K Baker, E M Baldin, P Balek, T Balestri, F Balli, W K Balunas, E Banas, Sw Banerjee, A A E Bannoura, L Barak, E L Barberio, D Barberis, M Barbero, T Barillari, M-S Barisits, T Barklow, N Barlow, S L Barnes, B M Barnett, R M Barnett, Z Barnovska, A Baroncelli, G Barone, A J Barr, L Barranco Navarro, F Barreiro, J Barreiro Guimarães da Costa, R Bartoldus, A E Barton, P Bartos, A Basalaev, A Bassalat, R L Bates, S J Batista, J R Batley, M Battaglia, M Bauce, F Bauer, H S Bawa, J B Beacham, M D Beattie, T Beau, P H Beauchemin, P Bechtle, H P Beck, K Becker, M Becker, M Beckingham, C Becot, A J Beddall, A Beddall, V A Bednyakov, M Bedognetti, C P Bee, L J Beemster, T A Beermann, M Begel, J K Behr, C Belanger-Champagne, A S Bell, G Bella, L Bellagamba, A Bellerive, M Bellomo, K Belotskiy, O Beltramello, N L Belyaev, O Benary, D Benchekroun, M Bender, K Bendtz, N Benekos, Y Benhammou, E Benhar Noccioli, J Benitez, D P Benjamin, J R Bensinger, S Bentvelsen, L Beresford, M Beretta, D Berge, E Bergeaas Kuutmann, N Berger, J Beringer, S Berlendis, N R Bernard, C Bernius, F U Bernlochner, T Berry, P Berta, C Bertella, G Bertoli, F Bertolucci, I A Bertram, C Bertsche, D Bertsche, G J Besjes, O Bessidskaia Bylund, M Bessner, N Besson, C Betancourt, A Bethani, S Bethke, A J Bevan, R M Bianchi, L Bianchini, M Bianco, O Biebel, D Biedermann, R Bielski, N V Biesuz, M Biglietti, J Bilbao De Mendizabal, T R V Billoud, H Bilokon, M Bindi, S Binet, A Bingul, C Bini, S Biondi, T Bisanz, D M Bjergaard, C W Black, J E Black, K M Black, D Blackburn, R E Blair, J-B Blanchard, T Blazek, I Bloch, C Blocker, W Blum, U Blumenschein, S Blunier, G J Bobbink, V S Bobrovnikov, S S Bocchetta, A Bocci, C Bock, M Boehler, D Boerner, J A Bogaerts, D Bogavac, A G Bogdanchikov, C Bohm, V Boisvert, P Bokan, T Bold, A S Boldyrev, M Bomben, M Bona, M Boonekamp, A Borisov, G Borissov, J Bortfeldt, D Bortoletto, V Bortolotto, K Bos, D Boscherini, M Bosman, J D Bossio Sola, J Boudreau, J Bouffard, E V Bouhova-Thacker, D Boumediene, C Bourdarios, S K Boutle, A Boveia, J Boyd, I R Boyko, J Bracinik, A Brandt, G Brandt, O Brandt, U Bratzler, B Brau, J E Brau, H M Braun, W D Breaden Madden, K Brendlinger, A J Brennan, L Brenner, R Brenner, S Bressler, T M Bristow, D Britton, D Britzger, F M Brochu, I Brock, R Brock, G Brooijmans, T Brooks, W K Brooks, J Brosamer, E Brost, J H Broughton, P A Bruckman de Renstrom, D Bruncko, R Bruneliere, A Bruni, G Bruni, L S Bruni, B H Brunt, M Bruschi, N Bruscino, P Bryant, L Bryngemark, T Buanes, Q Buat, P Buchholz, A G Buckley, I A Budagov, F Buehrer, M K Bugge, O Bulekov, D Bullock, H Burckhart, S Burdin, C D Burgard, B Burghgrave, K Burka, S Burke, I Burmeister, J T P Burr, E Busato, D Büscher, V Büscher, P Bussey, J M Butler, C M Buttar, J M Butterworth, P Butti, W Buttinger, A Buzatu, A R Buzykaev, S Cabrera Urbán, D Caforio, V M Cairo, O Cakir, N Calace, P Calafiura, A Calandri, G Calderini, P Calfayan, G Callea, L P Caloba, S Calvente Lopez, D Calvet, S Calvet, T P Calvet, R Camacho Toro, S Camarda, P Camarri, D Cameron, R Caminal Armadans, C Camincher, S Campana, M Campanelli, A Camplani, A Campoverde, V Canale, A Canepa, M Cano Bret, J Cantero, R Cantrill, T Cao, M D M Capeans Garrido, I Caprini, M Caprini, M Capua, R Caputo, R M Carbone, R Cardarelli, F Cardillo, I Carli, T Carli, G Carlino, L Carminati, S Caron, E Carquin, G D Carrillo-Montoya, J R Carter, J Carvalho, D Casadei, M P Casado, M Casolino, D W Casper, E Castaneda-Miranda, R Castelijn, A Castelli, V Castillo Gimenez, N F Castro, A Catinaccio, J R Catmore, A Cattai, J Caudron, V Cavaliere, E Cavallaro, D Cavalli, M Cavalli-Sforza, V Cavasinni, F Ceradini, L Cerda Alberich, B C Cerio, A S Cerqueira, A Cerri, L Cerrito, F Cerutti, M Cerv, A Cervelli, S A Cetin, A Chafaq, D Chakraborty, S K Chan, Y L Chan, P Chang, J D Chapman, D G Charlton, A Chatterjee, C C Chau, C A Chavez Barajas, S Che, S Cheatham, A Chegwidden, S Chekanov, S V Chekulaev, G A Chelkov, M A Chelstowska, C Chen, H Chen, K Chen, S Chen, S Chen, X Chen, Y Chen, H C Cheng, H J Cheng, Y Cheng, A Cheplakov, E Cheremushkina, R Cherkaoui El Moursli, V Chernyatin, E Cheu, L Chevalier, V Chiarella, G Chiarelli, G Chiodini, A S Chisholm, A Chitan, M V Chizhov, K Choi, A R Chomont, S Chouridou, B K B Chow, V Christodoulou, D Chromek-Burckhart, J Chudoba, A J Chuinard, J J Chwastowski, L Chytka, G Ciapetti, A K Ciftci, D Cinca, V Cindro, I A Cioara, C Ciocca, A Ciocio, F Cirotto, Z H Citron, M Citterio, M Ciubancan, A Clark, B L Clark, M R Clark, P J Clark, R N Clarke, C Clement, Y Coadou, M Cobal, A Coccaro, J Cochran, L Colasurdo, B Cole, A P Colijn, J Collot, T Colombo, G Compostella, P Conde Muiño, E Coniavitis, S H Connell, I A Connelly, V Consorti, S Constantinescu, G Conti, F Conventi, M Cooke, B D Cooper, A M Cooper-Sarkar, K J R Cormier, T Cornelissen, M Corradi, F Corriveau, A Corso-Radu, A Cortes-Gonzalez, G Cortiana, G Costa, M J Costa, D Costanzo, G Cottin, G Cowan, B E Cox, K Cranmer, S J Crawley, G Cree, S Crépé-Renaudin, F Crescioli, W A Cribbs, M Crispin Ortuzar, M Cristinziani, V Croft, G Crosetti, A Cueto, T Cuhadar Donszelmann, J Cummings, M Curatolo, J Cúth, H Czirr, P Czodrowski, G D'amen, S D'Auria, M D'Onofrio, M J Da Cunha Sargedas De Sousa, C Da Via, W Dabrowski, T Dado, T Dai, O Dale, F Dallaire, C Dallapiccola, M Dam, J R Dandoy, N P Dang, A C Daniells, N S Dann, M Danninger, M Dano Hoffmann, V Dao, G Darbo, S Darmora, J Dassoulas, A Dattagupta, W Davey, C David, T Davidek, M Davies, P Davison, E Dawe, I Dawson, R K Daya-Ishmukhametova, K De, R de Asmundis, A De Benedetti, S De Castro, S De Cecco, N De Groot, P de Jong, H De la Torre, F De Lorenzi, A De Maria, D De Pedis, A De Salvo, U De Sanctis, A De Santo, J B De Vivie De Regie, W J Dearnaley, R Debbe, C Debenedetti, D V Dedovich, N Dehghanian, I Deigaard, M Del Gaudio, J Del Peso, T Del Prete, D Delgove, F Deliot, C M Delitzsch, A Dell'Acqua, L Dell'Asta, M Dell'Orso, M Della Pietra, D Della Volpe, M Delmastro, P A Delsart, D A DeMarco, S Demers, M Demichev, A Demilly, S P Denisov, D Denysiuk, D Derendarz, J E Derkaoui, F Derue, P Dervan, K Desch, C Deterre, K Dette, P O Deviveiros, A Dewhurst, S Dhaliwal, A Di Ciaccio, L Di Ciaccio, W K Di Clemente, C Di Donato, A Di Girolamo, B Di Girolamo, B Di Micco, R Di Nardo, A Di Simone, R Di Sipio, D Di Valentino, C Diaconu, M Diamond, F A Dias, M A Diaz, E B Diehl, J Dietrich, S Diglio, A Dimitrievska, J Dingfelder, P Dita, S Dita, F Dittus, F Djama, T Djobava, J I Djuvsland, M A B do Vale, D Dobos, M Dobre, C Doglioni, J Dolejsi, Z Dolezal, M Donadelli, S Donati, P Dondero, J Donini, J Dopke, A Doria, M T Dova, A T Doyle, E Drechsler, M Dris, Y Du, J Duarte-Campderros, E Duchovni, G Duckeck, O A Ducu, D Duda, A Dudarev, A Chr Dudder, E M Duffield, L Duflot, M Dührssen, M Dumancic, M Dunford, H Duran Yildiz, M Düren, A Durglishvili, D Duschinger, B Dutta, M Dyndal, C Eckardt, K M Ecker, R C Edgar, N C Edwards, T Eifert, G Eigen, K Einsweiler, T Ekelof, M El Kacimi, V Ellajosyula, M Ellert, S Elles, F Ellinghaus, A A Elliot, N Ellis, J Elmsheuser, M Elsing, D Emeliyanov, Y Enari, O C Endner, J S Ennis, J Erdmann, A Ereditato, G Ernis, J Ernst, M Ernst, S Errede, E Ertel, M Escalier, H Esch, C Escobar, B Esposito, A I Etienvre, E Etzion, H Evans, A Ezhilov, F Fabbri, L Fabbri, G Facini, R M Fakhrutdinov, S Falciano, R J Falla, J Faltova, Y Fang, M Fanti, A Farbin, A Farilla, C Farina, E M Farina, T Farooque, S Farrell, S M Farrington, P Farthouat, F Fassi, P Fassnacht, D Fassouliotis, M Faucci Giannelli, A Favareto, W J Fawcett, L Fayard, O L Fedin, W Fedorko, S Feigl, L Feligioni, C Feng, E J Feng, H Feng, A B Fenyuk, L Feremenga, P Fernandez Martinez, S Fernandez Perez, J Ferrando, A Ferrari, P Ferrari, R Ferrari, D E Ferreira de Lima, A Ferrer, D Ferrere, C Ferretti, A Ferretto Parodi, F Fiedler, A Filipčič, M Filipuzzi, F Filthaut, M Fincke-Keeler, K D Finelli, M C N Fiolhais, L Fiorini, A Firan, A Fischer, C Fischer, J Fischer, W C Fisher, N Flaschel, I Fleck, P Fleischmann, G T Fletcher, R R M Fletcher, T Flick, A Floderus, L R Flores Castillo, M J Flowerdew, G T Forcolin, A Formica, A Forti, A G Foster, D Fournier, H Fox, S Fracchia, P Francavilla, M Franchini, D Francis, L Franconi, M Franklin, M Frate, M Fraternali, D Freeborn, S M Fressard-Batraneanu, F Friedrich, D Froidevaux, J A Frost, C Fukunaga, E Fullana Torregrosa, T Fusayasu, J Fuster, C Gabaldon, O Gabizon, A Gabrielli, A Gabrielli, G P Gach, S Gadatsch, S Gadomski, G Gagliardi, L G Gagnon, P Gagnon, C Galea, B Galhardo, E J Gallas, B J Gallop, P Gallus, G Galster, K K Gan, J Gao, Y Gao, Y S Gao, F M Garay Walls, C García, J E García Navarro, M Garcia-Sciveres, R W Gardner, N Garelli, V Garonne, A Gascon Bravo, K Gasnikova, C Gatti, A Gaudiello, G Gaudio, L Gauthier, I L Gavrilenko, C Gay, G Gaycken, E N Gazis, Z Gecse, C N P Gee, Ch Geich-Gimbel, M Geisen, M P Geisler, C Gemme, M H Genest, C Geng, S Gentile, C Gentsos, S George, D Gerbaudo, A Gershon, S Ghasemi, H Ghazlane, M Ghneimat, B Giacobbe, S Giagu, P Giannetti, B Gibbard, S M Gibson, M Gignac, M Gilchriese, T P S Gillam, D Gillberg, G Gilles, D M Gingrich, N Giokaris, M P Giordani, F M Giorgi, F M Giorgi, P F Giraud, P Giromini, D Giugni, F Giuli, C Giuliani, M Giulini, B K Gjelsten, S Gkaitatzis, I Gkialas, E L Gkougkousis, L K Gladilin, C Glasman, J Glatzer, P C F Glaysher, A Glazov, M Goblirsch-Kolb, J Godlewski, S 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T Scanlon, D A Scannicchio, M Scarcella, V Scarfone, J Schaarschmidt, P Schacht, B M Schachtner, D Schaefer, L Schaefer, R Schaefer, J Schaeffer, S Schaepe, S Schaetzel, U Schäfer, A C Schaffer, D Schaile, R D Schamberger, V Scharf, V A Schegelsky, D Scheirich, M Schernau, C Schiavi, S Schier, C Schillo, M Schioppa, S Schlenker, K R Schmidt-Sommerfeld, K Schmieden, C Schmitt, S Schmitt, S Schmitz, B Schneider, U Schnoor, L Schoeffel, A Schoening, B D Schoenrock, E Schopf, M Schott, J Schovancova, S Schramm, M Schreyer, N Schuh, A Schulte, M J Schultens, H-C Schultz-Coulon, H Schulz, M Schumacher, B A Schumm, Ph Schune, A Schwartzman, T A Schwarz, H Schweiger, Ph Schwemling, R Schwienhorst, J Schwindling, T Schwindt, G Sciolla, F Scuri, F Scutti, J Searcy, P Seema, S C Seidel, A Seiden, F Seifert, J M Seixas, G Sekhniaidze, K Sekhon, S J Sekula, D M Seliverstov, N Semprini-Cesari, C Serfon, L Serin, L Serkin, M Sessa, R Seuster, H Severini, T Sfiligoj, F Sforza, A Sfyrla, E Shabalina, N W Shaikh, L Y Shan, R Shang, J T Shank, M Shapiro, P B Shatalov, K Shaw, S M Shaw, A Shcherbakova, C Y Shehu, P Sherwood, L Shi, S Shimizu, C O Shimmin, M Shimojima, M Shiyakova, A Shmeleva, D Shoaleh Saadi, M J Shochet, S Shojaii, S Shrestha, E Shulga, M A Shupe, P Sicho, A M Sickles, P E Sidebo, O Sidiropoulou, D Sidorov, A Sidoti, F Siegert, Dj Sijacki, J Silva, S B Silverstein, V Simak, Lj Simic, S Simion, E Simioni, B Simmons, D Simon, M Simon, P Sinervo, N B Sinev, M Sioli, G Siragusa, S Yu Sivoklokov, J Sjölin, M B Skinner, H P Skottowe, P Skubic, M Slater, T Slavicek, M Slawinska, K Sliwa, R Slovak, V Smakhtin, B H Smart, L Smestad, J Smiesko, S Yu Smirnov, Y Smirnov, L N Smirnova, O Smirnova, M N K Smith, R W Smith, M Smizanska, K Smolek, A A Snesarev, S Snyder, R Sobie, F Socher, A Soffer, D A Soh, G Sokhrannyi, C A Solans Sanchez, M Solar, E Yu Soldatov, U Soldevila, A A Solodkov, A Soloshenko, O V Solovyanov, V Solovyev, P Sommer, H Son, H Y Song, A Sood, A Sopczak, V Sopko, V Sorin, D Sosa, C L Sotiropoulou, R Soualah, A M Soukharev, D South, B C Sowden, S Spagnolo, M Spalla, M Spangenberg, F Spanò, D Sperlich, F Spettel, R Spighi, G Spigo, L A Spiller, M Spousta, R D St Denis, A Stabile, R Stamen, S Stamm, E Stanecka, R W Stanek, C Stanescu, M Stanescu-Bellu, M M Stanitzki, S Stapnes, E A Starchenko, G H Stark, J Stark, P Staroba, P Starovoitov, S Stärz, R Staszewski, P Steinberg, B Stelzer, H J Stelzer, O Stelzer-Chilton, H Stenzel, G A Stewart, J A Stillings, M C Stockton, M Stoebe, G Stoicea, P Stolte, S Stonjek, A R Stradling, A Straessner, M E Stramaglia, J Strandberg, S Strandberg, A Strandlie, M Strauss, P Strizenec, R Ströhmer, D M Strom, R Stroynowski, A Strubig, S A Stucci, B Stugu, N A Styles, D Su, J Su, S Suchek, Y Sugaya, M Suk, V V Sulin, S Sultansoy, T Sumida, S Sun, X Sun, J E Sundermann, K Suruliz, G Susinno, M R Sutton, S Suzuki, M Svatos, M Swiatlowski, I Sykora, T Sykora, D Ta, C Taccini, K Tackmann, J Taenzer, A Taffard, R Tafirout, N Taiblum, H Takai, R Takashima, T Takeshita, Y Takubo, M Talby, A A Talyshev, K G Tan, J Tanaka, M Tanaka, R Tanaka, S Tanaka, B B Tannenwald, S Tapia Araya, S Tapprogge, S Tarem, G F Tartarelli, P Tas, M Tasevsky, T Tashiro, E Tassi, A Tavares Delgado, Y Tayalati, A C Taylor, G N Taylor, P T E Taylor, W Taylor, F A Teischinger, P Teixeira-Dias, K K Temming, D Temple, H Ten Kate, P K Teng, J J Teoh, F Tepel, S Terada, K Terashi, J Terron, S Terzo, M Testa, R J Teuscher, T Theveneaux-Pelzer, J P Thomas, J Thomas-Wilsker, E N Thompson, P D Thompson, A S Thompson, L A Thomsen, E Thomson, M Thomson, M J Tibbetts, R E Ticse Torres, V O Tikhomirov, Yu A Tikhonov, S Timoshenko, P Tipton, S Tisserant, K Todome, T Todorov, S Todorova-Nova, J Tojo, S Tokár, K Tokushuku, E Tolley, L Tomlinson, M Tomoto, L Tompkins, K Toms, B Tong, E Torrence, H Torres, E Torró Pastor, J Toth, F Touchard, D R Tovey, T Trefzger, A Tricoli, I M Trigger, S Trincaz-Duvoid, M F Tripiana, W Trischuk, B Trocmé, A Trofymov, C Troncon, M Trottier-McDonald, M Trovatelli, L Truong, M Trzebinski, A Trzupek, J C-L Tseng, P V Tsiareshka, G Tsipolitis, N Tsirintanis, S Tsiskaridze, V Tsiskaridze, E G Tskhadadze, K M Tsui, I I Tsukerman, V Tsulaia, S Tsuno, D Tsybychev, Y Tu, A Tudorache, V Tudorache, A N Tuna, S A Tupputi, S Turchikhin, D Turecek, D Turgeman, R Turra, A J Turvey, P M Tuts, M Tyndel, G Ucchielli, I Ueda, M Ughetto, F Ukegawa, G Unal, A Undrus, G Unel, F C Ungaro, Y Unno, C Unverdorben, J Urban, P Urquijo, P Urrejola, G Usai, A Usanova, L Vacavant, V Vacek, B Vachon, C Valderanis, E Valdes Santurio, N Valencic, S Valentinetti, A Valero, L Valery, S Valkar, J A Valls Ferrer, W Van Den Wollenberg, P C Van Der Deijl, H van der Graaf, N van Eldik, P van Gemmeren, J Van Nieuwkoop, I van Vulpen, M C van Woerden, M Vanadia, W Vandelli, R Vanguri, A Vaniachine, P Vankov, G Vardanyan, R Vari, E W Varnes, T Varol, D Varouchas, A Vartapetian, K E Varvell, J G Vasquez, F Vazeille, T Vazquez Schroeder, J Veatch, V Veeraraghavan, L M Veloce, F Veloso, S Veneziano, A Ventura, M Venturi, N Venturi, A Venturini, V Vercesi, M Verducci, W Verkerke, J C Vermeulen, A Vest, M C Vetterli, O Viazlo, I Vichou, T Vickey, O E Vickey Boeriu, G H A Viehhauser, S Viel, L Vigani, M Villa, M Villaplana Perez, E Vilucchi, M G Vincter, V B Vinogradov, C Vittori, I Vivarelli, S Vlachos, M Vlasak, M Vogel, P Vokac, G Volpi, M Volpi, H von der Schmitt, E von Toerne, V Vorobel, K Vorobev, M Vos, R Voss, J H Vossebeld, N Vranjes, M Vranjes Milosavljevic, V Vrba, M Vreeswijk, R Vuillermet, I Vukotic, Z Vykydal, P Wagner, W Wagner, H Wahlberg, S Wahrmund, J Wakabayashi, J Walder, R Walker, W Walkowiak, V Wallangen, C Wang, C Wang, F Wang, H Wang, H Wang, J Wang, J Wang, K Wang, R Wang, S M Wang, T Wang, T Wang, W Wang, X Wang, C Wanotayaroj, A Warburton, C P Ward, D R Wardrope, A Washbrook, P M Watkins, A T Watson, M F Watson, G Watts, S Watts, B M Waugh, S Webb, M S Weber, S W Weber, J S Webster, A R Weidberg, B Weinert, J Weingarten, C Weiser, H Weits, P S Wells, T Wenaus, T Wengler, S Wenig, N Wermes, M Werner, M D Werner, P Werner, M Wessels, J Wetter, K Whalen, N L Whallon, A M Wharton, A White, M J White, R White, D Whiteson, F J Wickens, W Wiedenmann, M Wielers, P Wienemann, C Wiglesworth, L A M Wiik-Fuchs, A Wildauer, F Wilk, H G Wilkens, H H Williams, S Williams, C Willis, S Willocq, J A Wilson, I Wingerter-Seez, F Winklmeier, O J Winston, B T Winter, M Wittgen, J Wittkowski, T M H Wolf, M W Wolter, H Wolters, S D Worm, B K Wosiek, J Wotschack, M J Woudstra, K W Wozniak, M Wu, M Wu, S L Wu, X Wu, Y Wu, T R Wyatt, B M Wynne, S Xella, D Xu, L Xu, B Yabsley, S Yacoob, D Yamaguchi, Y Yamaguchi, A Yamamoto, S Yamamoto, T Yamanaka, K Yamauchi, Y Yamazaki, Z Yan, H Yang, H Yang, Y Yang, Z Yang, W-M Yao, Y C Yap, Y Yasu, E Yatsenko, K H Yau Wong, J Ye, S Ye, I Yeletskikh, A L Yen, E Yildirim, K Yorita, R Yoshida, K Yoshihara, C Young, C J S Young, S Youssef, D R Yu, J Yu, J M Yu, J Yu, L Yuan, S P Y Yuen, I Yusuff, B Zabinski, R Zaidan, A M Zaitsev, N Zakharchuk, J Zalieckas, A Zaman, S Zambito, L Zanello, D Zanzi, C Zeitnitz, M Zeman, A Zemla, J C Zeng, Q Zeng, K Zengel, O Zenin, T Ženiš, D Zerwas, D Zhang, F Zhang, G Zhang, H Zhang, J Zhang, L Zhang, R Zhang, R Zhang, X Zhang, Z Zhang, X Zhao, Y Zhao, Z Zhao, A Zhemchugov, J Zhong, B Zhou, C Zhou, L Zhou, L Zhou, M Zhou, N Zhou, C G Zhu, H Zhu, J Zhu, Y Zhu, X Zhuang, K Zhukov, A Zibell, D Zieminska, N I Zimine, C Zimmermann, S Zimmermann, Z Zinonos, M Zinser, M Ziolkowski, L Živković, G Zobernig, A Zoccoli, M Zur Nedden, L Zwalinski
This Letter presents a measurement of the inelastic proton-proton cross section using 60  μb^{-1} of pp collisions at a center-of-mass energy sqrt[s] of 13 TeV with the ATLAS detector at the LHC. Inelastic interactions are selected using rings of plastic scintillators in the forward region (2.07<|η|<3.86) of the detector. A cross section of 68.1±1.4  mb is measured in the fiducial region ξ=M_{X}^{2}/s>10^{-6}, where M_{X} is the larger invariant mass of the two hadronic systems separated by the largest rapidity gap in the event...
October 28, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27832007/myopericytoma-of-the-internal-auditory-canal
#14
Jacob B Hunter, Brendan P O'Connell, Woon N Chow, Kyle D Weaver, Justin M Cates, George B Wanna
No abstract text is available yet for this article.
November 9, 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27821083/single-administration-of-selective-internal-radiation-therapy-versus-continuous-treatment-with-sorafenib-in-locally-advanced-hepatocellular-carcinoma-sirvenib-study-protocol-for-a-phase-iii-randomized-controlled-trial
#15
Mihir Gandhi, Su Pin Choo, Choon Hua Thng, Say Beng Tan, Albert Su Chong Low, Peng Chung Cheow, Anthony Soon Whatt Goh, Kiang Hiong Tay, Richard Hoau Gong Lo, Brian Kim Poh Goh, Jen San Wong, David Chee Eng Ng, Khee Chee Soo, Wei Ming Liew, Pierce K H Chow
BACKGROUND: Approximately 20 % of hepatocellular carcinoma (HCC) patients diagnosed in the early stages may benefit from potentially curative ablative therapies such as surgical resection, transplantation or radiofrequency ablation. For patients not eligible for such options, prognosis is poor. Sorafenib and Selective Internal Radiation Therapy (SIRT) are clinically proven treatment options in patients with unresectable HCC, and this study aims to assess overall survival following either SIRT or Sorafenib therapy for locally advanced HCC patients...
November 7, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27818938/modulation-of-ambient-temperature-promotes-inflammation-and-initiates-atherosclerosis-in-wild-type-c57bl-6-mice
#16
Daniel A Giles, Bhama Ramkhelawon, Elizabeth M Donelan, Traci E Stankiewicz, Susan B Hutchison, Rajib Mukherjee, Monica Cappelletti, Rebekah Karns, Christopher L Karp, Kathryn J Moore, Senad Divanovic
OBJECTIVES: Obesity and obesity-associated inflammation is central to a variety of end-organ sequelae including atherosclerosis, a leading cause of death worldwide. Although mouse models have provided important insights into the immunopathogenesis of various diseases, modeling atherosclerosis in mice has proven difficult. Specifically, wild-type (WT) mice are resistant to developing atherosclerosis, while commonly used genetically modified mouse models of atherosclerosis are poor mimics of human disease...
November 2016: Molecular Metabolism
https://www.readbyqxmd.com/read/27794199/long-term-treatment-with-the-beta-3-adrenoceptor-agonist-mirabegron-ameliorates-detrusor-overactivity-and-restores-cyclic-adenosine-monophosphate-camp-levels-in-obese-mice
#17
Fabiano B Calmasini, Mariana G de Oliveira, Eduardo C Alexandre, Fábio H da Silva, Carmem P V da Silva, Tuany Z Candido, Edson Antunes, Fabíola Z Mónica
AIMS: To evaluate the effects of the beta-3 adrenoceptor agonist, mirabegron in a mouse model of detrusor overactivity induced by obesity. METHODS: C57BL/6 male mice were fed with standard chow or high-fat diet for 12 weeks. Lean and obese mice were treated orally with mirabegron (10 mg/kg/day) from the last 2 weeks of diet. Cystometric evaluations, functional assays, protein expression for phosphodiesterase type 4 (PDE4), and cyclic adenosine monophosphate (cAMP) measurement were carried out...
October 29, 2016: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/27787390/high-25-hydroxyvitamin-d-is-associated-with-unexpectedly-high-plasma-inflammatory-markers-in-hiv-patients-on-antiretroviral-therapy
#18
Louie Mar A Gangcuangco, Lindsay B Kohorn, Dominic C Chow, Sheila M Keating, Philip J Norris, Lorna S Nagamine, Lishomwa C Ndhlovu, Scott A Souza, Kalpana J Kallianpur, Cecilia M Shikuma
Inflammation associated with low 25-hydroxyvitamin D (25(OH)D) is associated with increased morbidity and mortality among HIV-infected patients with vitamin D deficiency. We investigated the association between 25(OH)D and soluble biomarkers among HIV-infected patients on stable antiretroviral therapy. This is a cross-sectional study. This study focuses on assessment in subjects 40 years or older on stable antiretroviral therapy (ART) for >3 months. Chemiluminescent immunoassay was used to determine plasma 25(OH)D levels...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27786334/cd70-limits-atherosclerosis-and-promotes-macrophage-function
#19
Holger Winkels, Svenja Meiler, Esther Smeets, Dirk Lievens, David Engel, Charlotte Spitz, Christina Bürger, Petteri Rinne, Linda Beckers, Angelika Dandl, Sigrid Reim, Maiwand Ahmadsei, Jan Van den Bossche, Lesca M Holdt, Remco T A Megens, Martin Schmitt, Menno de Winther, Eric A Biessen, Jannie Borst, Alexander Faussner, Christian Weber, Esther Lutgens, Norbert Gerdes
The co-stimulatory molecule CD70 is expressed on activated immune cells and is known to modulate responses of T, B, and NK cells via its receptor CD27. Until now, there is only limited data describing the role of CD70 in atherosclerosis. We observed that ruptured human carotid atherosclerotic plaques displayed higher CD70 expression than stable carotid atherosclerotic plaques, and that CD70 expression in murine atheroma localized to macrophages. Lack of CD70 impaired the inflammatory capacity (e. g. reactive oxygen species and nitric oxide production) of bone marrow-derived macrophages, increased both M1-like and M2-like macrophage markers, and rendered macrophages metabolically inactive and prone to apoptosis...
October 27, 2016: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/27771588/age-related-periodontitis-and-alveolar-bone-loss-in-rice-rats
#20
J I Aguirre, M P Akhter, K G Neuville, C R Trcalek, A M Leeper, A A Williams, M Rivera, L Kesavalu, H Z Ke, M Liu, D B Kimmel
OBJECTIVE: To characterize in rice rats: (a) periodontitis (PD) progress with feeding of standard laboratory rat chow (STD) during ages 4-80 weeks; and (b) PD progress with feeding of a high sucrose-casein (H-SC) diet during young adulthood. METHODS: One group (N=12) was euthanized at age 4 weeks (Baseline). Four groups (N=8-16) consumed a STD diet from baseline and were necropsied at ages 22, 30, 52, and 80 weeks. Three groups (N=10-16) consumed an H-SC diet from baseline...
October 17, 2016: Archives of Oral Biology
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