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white matter lesions, MR perfusion

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https://www.readbyqxmd.com/read/27231225/dynamic-susceptibility-contrast-enhanced-mr-perfusion-imaging-in-assessing-recurrent-glioblastoma-response-to-superselective-intra-arterial-bevacizumab-therapy
#1
R Singh, K Kesavabhotla, S A Kishore, Z Zhou, A J Tsiouris, C G Filippi, J A Boockvar, I Kovanlikaya
BACKGROUND AND PURPOSE: Recurrent glioblastoma currently has no established standard of care. We evaluated the response of recurrent glioblastoma to superselective intra-arterial cerebral infusion of bevacizumab by using dynamic susceptibility contrast-enhanced MR perfusion imaging. We hypothesized that treatment response would be associated with decreased relative CBV and relative CBF. MATERIALS AND METHODS: Patients were accrued for this study from larger ongoing serial Phase I/II trials...
May 26, 2016: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/26916251/comparison-of-diffusion-tensor-imaging-and-magnetic-resonance-perfusion-imaging-in-differentiating-recurrent-brain-neoplasm-from-radiation-necrosis
#2
William R Masch, Page I Wang, Thomas L Chenevert, Larry Junck, Christina Tsien, Jason A Heth, Pia C Sundgren
RATIONALE AND OBJECTIVES: To compare differences in diffusion tensor imaging (DTI) and dynamic susceptibility-weighted contrast-enhanced (DSC) magnetic resonance (MR) perfusion imaging characteristics of recurrent neoplasm and radiation necrosis in patients with brain tumors previously treated with radiotherapy with or without surgery and chemotherapy. MATERIALS AND METHODS: Patients with a history of brain neoplasm previously treated with radiotherapy with or without chemotherapy and surgery who developed a new enhancing lesion on posttreatment surveillance MRI were enrolled...
May 2016: Academic Radiology
https://www.readbyqxmd.com/read/26438560/high-resolution-blood-pool-contrast-enhanced-mr-angiography-in-glioblastoma-tumor-associated-neovascularization-as-a-biomarker-for-patient-survival-a-preliminary-study
#3
Josep Puig, Gerard Blasco, Josep Daunis-I-Estadella, Angel Alberich-Bayarri, Marco Essig, Rajan Jain, Sebastián Remollo, David Hernández, Montserrat Puigdemont, Javier Sánchez-González, Gloria Mateu, Max Wintermark, Salvador Pedraza
INTRODUCTION: The objective of the study was to determine whether tumor-associated neovascularization on high-resolution gadofosveset-enhanced magnetic resonance angiography (MRA) is a useful biomarker for predicting survival in patients with newly diagnosed glioblastomas. METHODS: Before treatment, 35 patients (25 men; mean age, 64 ± 14 years) with glioblastoma underwent MRI including first-pass dynamic susceptibility contrast (DSC) perfusion and post-contrast T1WI sequences with gadobutrol (0...
January 2016: Neuroradiology
https://www.readbyqxmd.com/read/26183648/automatic-brain-tumour-detection-and-neovasculature-assessment-with-multiseries-mri-analysis
#4
Pawel Szwarc, Jacek Kawa, Marcin Rudzki, Ewa Pietka
In this paper a novel multi-stage automatic method for brain tumour detection and neovasculature assessment is presented. First, the brain symmetry is exploited to register the magnetic resonance (MR) series analysed. Then, the intracranial structures are found and the region of interest (ROI) is constrained within them to tumour and peritumoural areas using the Fluid Light Attenuation Inversion Recovery (FLAIR) series. Next, the contrast-enhanced lesions are detected on the basis of T1-weighted (T1W) differential images before and after contrast medium administration...
December 2015: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://www.readbyqxmd.com/read/25410230/central-nervous-system-imaging-in-diabetic-cerebrovascular-diseases-and-white-matter-hyperintensities
#5
REVIEW
Simerpreet Bal, Mayank Goyal, Eric Smith, Andrew M Demchuk
Diabetes mellitus is an important vascular risk factor for cerebrovascular disease. This occurs through pathophysiologic changes to the microcirculation as arteriolosclerosis and to the macrocirculation as large artery atherosclerosis. Imaging techniques can provide detailed visualization of the cerebrovasculature using CT (computed tomography) angiography and MR (magnetic resonance) angiography. Newer techniques focused on advanced parenchymal imaging include CT perfusion, quantitative MRI, and diffusion tensor imaging; each identifies brain lesion burden due to diabetes mellitus...
2014: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/25330386/differentiation-of-brain-abscesses-from-glioblastomas-and-metastatic-brain-tumors-comparisons-of-diagnostic-performance-of-dynamic-susceptibility-contrast-enhanced-perfusion-mr-imaging-before-and-after-mathematic-contrast-leakage-correction
#6
COMPARATIVE STUDY
Cheng Hong Toh, Kuo-Chen Wei, Chen-Nen Chang, Shu-Hang Ng, Ho-Fai Wong, Ching-Po Lin
PURPOSE: To compare the diagnostic performance of dynamic susceptibility contrast-enhanced perfusion MRI before and after mathematic contrast leakage correction in differentiating pyogenic brain abscesses from glioblastomas and/or metastatic brain tumors. MATERIALS AND METHODS: Cerebral blood volume (CBV), leakage-corrected CBV and leakage coefficient K2 were measured in enhancing rims, perifocal edema and contralateral normal appearing white matter (NAWM) of 17 abscesses, 19 glioblastomas and 20 metastases, respectively...
2014: PloS One
https://www.readbyqxmd.com/read/25319529/changes-of-migraine-related-white-matter-hyperintensities-after-3-years-a-longitudinal-mri-study
#7
Szilvia Erdélyi-Bótor, Mihály Aradi, David Olayinka Kamson, Norbert Kovács, Gábor Perlaki, Gergely Orsi, Szilvia Anett Nagy, Attila Schwarcz, Tamás Dóczi, Sámuel Komoly, Gabriella Deli, Anita Trauninger, Zoltán Pfund
OBJECTIVE/BACKGROUND: The aim of this longitudinal study was to investigate changes of migraine-related brain white matter hyperintensities 3 years after an initial study. Baseline quantitative magnetic resonance imaging (MRI) studies of migraine patients with hemispheric white matter hyperintensities performed in 2009 demonstrated signs of tissue damage within the hyperintensities. The hyperintensities appeared most frequently in the deep white matter of the frontal lobe with a similar average hyperintensity size in all hemispheric lobes...
January 2015: Headache
https://www.readbyqxmd.com/read/24651815/diffusion-and-perfusion-mri-findings-of-the-signal-intensity-abnormalities-of-brain-associated-with-developmental-venous-anomaly
#8
H N Jung, S T Kim, J Cha, H J Kim, H S Byun, P Jeon, K H Kim, B-J Kim, H-J Kim
BACKGROUND AND PURPOSE: Developmental venous anomalies are the most common intracranial vascular malformation. Increased signal-intensity on T2-FLAIR images in the areas drained by developmental venous anomalies are encountered occasionally on brain imaging studies. We evaluated diffusion and perfusion MR imaging findings of the abnormally high signal intensity associated with developmental venous anomalies to describe their pathophysiologic nature. MATERIALS AND METHODS: We retrospectively reviewed imaging findings of 34 subjects with signal-intensity abnormalities associated with developmental venous anomalies...
August 2014: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/24324699/the-role-of-dynamic-susceptibility-contrast-enhanced-perfusion-mr-imaging-in-differentiating-between-infectious-and-neoplastic-focal-brain-lesions-results-from-a-cohort-of-100-consecutive-patients
#9
Valdeci Hélio Floriano, Ulysses S Torres, Antonio Ronaldo Spotti, José Roberto Lopes Ferraz-Filho, Waldir Antônio Tognola
BACKGROUND AND PURPOSE: Differentiating between infectious and neoplastic focal brain lesions that are detected by conventional structural magnetic resonance imaging (MRI) may be a challenge in routine practice. Brain perfusion-weighted MRI (PWI) may be employed as a complementary non-invasive tool, providing relevant data on hemodynamic parameters, such as the degree of angiogenesis of lesions. We aimed to employ dynamic susceptibility contrast-enhanced perfusion MR imaging (DSC-MRI) to differentiate between infectious and neoplastic brain lesions by investigating brain microcirculation changes...
2013: PloS One
https://www.readbyqxmd.com/read/23592805/pseudoprogression-in-patients-with-glioblastoma-added-value-of-arterial-spin-labeling-to-dynamic-susceptibility-contrast-perfusion-mr-imaging
#10
Young Jun Choi, Ho Sung Kim, Geon-Ho Jahng, Sang Joon Kim, Dae Chul Suh
BACKGROUND: Pseudoprogression is a treatment-related reaction with an increase in contrast-enhancing lesion size, followed by subsequent improvement. Differentiating tumor recurrence from pseudoprogression remains a problem in neuro-oncology. PURPOSE: To validate the added value of arterial spin labeling (ASL), compared with dynamic susceptibility contrast (DSC) perfusion magnetic resonance imaging (MRI) alone, in distinguishing early tumor progression from pseudoprogression in patients with newly diagnosed glioblastoma multiforme (GBM)...
May 2013: Acta Radiologica
https://www.readbyqxmd.com/read/23548916/the-neuroaid-ii-mlc901-in-vascular-cognitive-impairment-study-neurites
#11
Christopher L H Chen, Kamran Ikram, Qiu Anqi, Wong Tien Yin, Annabel Chen, Narayanaswamy Venketasubramanian
BACKGROUND: A substantial proportion of patients after nondisabling stroke are cognitively impaired compared to age- and education-matched community-dwelling controls. Moreover, poststroke patients who have 'vascular cognitive impairment no dementia' (VCIND) of moderate severity have a high risk of incident dementia, dependency and death. Further studies are urgently needed to demonstrate effective cognition-enhancing therapies in VCIND given the scarcity of evidence-based treatment options...
2013: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/23373450/strategies-to-maximize-resection-of-complex-or-high-surgical-risk-low-grade-gliomas
#12
Jessica A Wilden, Jason Voorhies, Kristine M Mosier, Darren P O'Neill, Aaron A Cohen-Gadol
OBJECT: Early and aggressive resection of low-grade gliomas (LGGs) leads to increased overall patient survival, decreased malignant progression, and better seizure control. This case series describes the authors' approach to achieving optimal neurological and surgical outcomes in patients referred by outside neurosurgeons for stereotactic biopsy of tumors believed to be complex or a high surgical risk, due to their diffuse nature on neuroimaging and their obvious infiltration of functional cortex...
February 2013: Neurosurgical Focus
https://www.readbyqxmd.com/read/22759720/flair-vascular-hyperintensities-in-acute-ica-and-mca-infarction-a-marker-for-mismatch-and-stroke-severity
#13
M Hohenhaus, W U Schmidt, P Brunecker, C Xu, B Hotter, M Rozanski, J B Fiebach, G J Jungehülsing
BACKGROUND: Vascular hyperintensities of brain-supplying arteries on stroke FLAIR MRI are common and represent slow flow or stasis. FLAIR vascular hyperintensities (FVH) are discussed as an independent marker for cerebral hypoperfusion, but the impact on infarct size and clinical outcome in acute stroke patients is controversial. This study evaluates the association of FVH with infarct morphology, clinical stroke severity and infarct growth in patients with symptomatic internal carotid artery (ICA) or middle cerebral artery (MCA) occlusion...
2012: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/22744350/magnetic-resonance-imaging-of-solitary-brain-metastases-main-findings-of-nonmorphological-sequences
#14
S Gaudino, G M Di Lella, R Russo, V S Lo Russo, F Piludu, F R Quaglio, M R Gualano, C De Waure, C Colosimo
PURPOSE: This study was done to investigate the usefulness of diffusion-weighted (DWI), perfusion-weighted (PWI) and proton magnetic resonance (MR) spectroscopy imaging in characterising solitary brain metastases. MATERIALS AND METHODS: Fifty-nine solitary brain metastases were evaluated with conventional and nonmorphological MR imaging: DWI, PWI and MR spectroscopy. We evaluated size, signal intensity and contrast enhancement and calculated apparent diffusion coefficient (ADC), relative cerebral blood volume (rCBV), percentage of signal intensity recovery (PSR) and maximum values of N-acetylaspartate (NAA), choline (Cho), creatine (Cr), lipids (Lip), NAA/Cr and Cho/Cr...
October 2012: La Radiologia Medica
https://www.readbyqxmd.com/read/22742818/cerebral-small-vessel-disease-in-aging-and-alzheimer-s-disease-a-comparative-study-using-mri-and-spect
#15
COMPARATIVE STUDY
I Makedonov, S E Black, B J MacIntosh
BACKGROUND: White matter hyperintensities (WMH) are associated with aging and are prevalent in various brain pathologies. The purpose of the current study was to characterize WMH perfusion in age-matched elderly controls (ECs) and patients with Alzheimer's disease (ADs). METHODS: Fifty ECs (23 men) and 61 ADs (33 men) underwent magnetic resonance imaging (MRI), 99mTc-ECD single-photon emission computed tomography (SPECT) and cognitive testing. Brain tissue type was classified on T1 weighted images, and WMH were identified on interleaved proton density/T2 weighted images...
February 2013: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/22548938/current-status-and-future-perspectives-of-magnetic-resonance-high-field-imaging-a-summary
#16
REVIEW
Vivek Prabhakaran, Veena A Nair, Benjamin P Austin, Christian La, Thomas A Gallagher, Yijing Wu, Donald G McLaren, Guofan Xu, Patrick Turski, Howard Rowley
There are several magnetic resonance (MR) imaging techniques that benefit from high-field MR imaging. This article describes a range of novel techniques that are currently being used clinically or will be used in the future for clinical purposes as they gain popularity. These techniques include functional MR imaging, diffusion tensor imaging, cortical thickness assessment, arterial spin labeling perfusion, white matter hyperintensity lesion assessment, and advanced MR angiography.
May 2012: Neuroimaging Clinics of North America
https://www.readbyqxmd.com/read/22389820/herpes-encephalitis-masquerading-as-tumor
#17
Tasneem Peeraully, Joseph C Landolfi
A 54 year old lady presented with lethargy and 15 kg weight loss over the past year. CT scan of the head revealed left temporal lobe hypodensity with a discrete area of hemorrhage within the left mesial temporal lobe. Due to concerns about impending central herniation, lumbar puncture was not performed. MRI of the brain showed a large lesion of the left temporal lobe, extending to the left frontal lobe, and very patchy meningeal enhancement. There was a noncontiguous lesion of the right insula. A differential diagnosis of herpes simplex encephalitis (HSE) and multifocal infiltrative glioma was entertained...
2011: ISRN Neurology
https://www.readbyqxmd.com/read/22159052/magnetic-resonance-techniques-in-multiple-sclerosis-the-present-and-the-future
#18
REVIEW
Massimo Filippi, Maria A Rocca, Nicola De Stefano, Christian Enzinger, Elizabeth Fisher, Mark A Horsfield, Matilde Inglese, Daniel Pelletier, Giancarlo Comi
Magnetic resonance imaging (MRI) is sensitive to focal multiple sclerosis (MS) lesions. For this reason, conventional MRI measures of the burden of disease derived from dual-echo, fluid-attenuated inversion recovery and postcontrast T1-weighted sequences are regularly used to monitor disease course in patients with confirmed MS and have been included in the diagnostic workup of patients in whom MS is suspected. Other quantitative magnetic resonance (MR)-based techniques with a higher pathological specificity (including magnetization transfer-MRI, diffusion tensor-MRI, and proton MR spectroscopy) have been extensively applied to measure disease burden within focal visible lesions and in the normal-appearing white matter and gray matter of MS patients at different stages of the disease...
December 2011: Archives of Neurology
https://www.readbyqxmd.com/read/22141606/distinction-between-postoperative-recurrent-glioma-and-delayed-radiation-injury-using-mr-perfusion-weighted-imaging
#19
Jun-Ling Xu, Da-Peng Shi, She-wei Dou, Yong-Li Li, Feng-shan Yan
INTRODUCTION: Distinction between postoperative recurrent glioma and radiation injury remains a tough diagnostic problem for routine imaging methods. The purpose of this study is to evaluate the differentiated effectiveness of perfusion weighted imaging (PWI) for the two entities. METHODS: PWI was performed using Siemens 3.0-T MR system for 35 patients with new contrast-enhancing lesions at the site of treated glioma. Regions of interest (ROIs) were manually drawn at the contrast-enhancing lesion and peri-lesion edema areas...
December 2011: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/22002882/comparison-of-3-tesla-proton-mr-spectroscopy-mr-perfusion-and-mr-diffusion-for-distinguishing-glioma-recurrence-from-posttreatment-effects
#20
COMPARATIVE STUDY
James R Fink, Robert B Carr, Eiji Matsusue, Ramesh S Iyer, Jason K Rockhill, David R Haynor, Kenneth R Maravilla
PURPOSE: To compare 3 Tesla (3T) multi-voxel and single-voxel proton MR spectroscopy (MRS), dynamic susceptibility contrast perfusion MRI (DSC), and diffusion-weighted MRI (DWI) for distinguishing recurrent glioma from postradiation injury. MATERIALS AND METHODS: We reviewed all 3T MRS, DSC and DWI studies performed for suspicion of malignant glioma recurrence between October 2006 and December 2008. Maximum Cho/NAA and Cho/Cr peak-area and peak-height ratios were recorded for both multi-voxel and single-voxel MRS...
January 2012: Journal of Magnetic Resonance Imaging: JMRI
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