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white matter lesions, MR perfusion

Cen Zhang, John A Detre, Scott E Kasner, Brett Cucchiara
Objective: The objective of this study is to determine whether structural features of the vertebrobasilar arterial system are related to migraine. Background: Alterations in cerebral vascular structure and function have been associated with migraine, possibly mediated by hypoperfusion and/or endothelial dysfunction triggering cortical spreading depression. Vessel tortuosity, in particular, has been associated with both altered hemodynamics and endothelial function...
2018: Frontiers in Neurology
E Lapointe, D K B Li, A L Traboulsee, A Rauscher
Using MR imaging, perfusion can be assessed either by dynamic susceptibility contrast MR imaging or arterial spin-labeling. Alterations of cerebral perfusion have repeatedly been described in multiple sclerosis compared with healthy controls. Acute lesions exhibit relative hyperperfusion in comparison with normal-appearing white matter, a finding mostly attributed to inflammation in this stage of lesion development. In contrast, normal-appearing white and gray matter of patients with MS has been mostly found to be hypoperfused compared with controls, and correlations with cognitive impairment as well as fatigue in multiple sclerosis have been described...
January 4, 2018: AJNR. American Journal of Neuroradiology
A D Mulholland, R Vitorino, S-P Hojjat, A Y Ma, L Zhang, L Lee, T J Carroll, C G Cantrell, C R Figley, R I Aviv
BACKGROUND AND PURPOSE: The spatial correlation between WM and cortical GM disease in multiple sclerosis is controversial and has not been previously assessed with perfusion MR imaging. We sought to determine the nature of association between lobar WM, cortical GM, volume and perfusion. MATERIALS AND METHODS: Nineteen individuals with secondary-progressive multiple sclerosis, 19 with relapsing-remitting multiple sclerosis, and 19 age-matched healthy controls were recruited...
November 2, 2017: AJNR. American Journal of Neuroradiology
Joo-Seok Lee, Tae-Young Jung, Kyung-Hwa Lee, Seul-Kee Kim
We report a case of primary central nervous system vasculitis (PCNSV) mimicking a cortical brain tumor. A 25-year-old woman presented with a 2-week history of headache and transient right hemiparesis. Brain magnetic resonance imaging (MRI) revealed a cortical-involving lesion on the left frontal lobe. The 6-cm sized lesion showed low signal intensity on T1-weighted images and high signal intensity on T2-weighted images. The lesion had continual linear enhancement on the subcortical white matter and leptomeninges...
April 2017: Brain Tumor Research and Treatment
R Singh, K Kesavabhotla, S A Kishore, Z Zhou, A J Tsiouris, C G Filippi, J A Boockvar, I Kovanlikaya
BACKGROUND AND PURPOSE: Recurrent glioblastoma currently has no established standard of care. We evaluated the response of recurrent glioblastoma to superselective intra-arterial cerebral infusion of bevacizumab by using dynamic susceptibility contrast-enhanced MR perfusion imaging. We hypothesized that treatment response would be associated with decreased relative CBV and relative CBF. MATERIALS AND METHODS: Patients were accrued for this study from larger ongoing serial Phase I/II trials...
May 26, 2016: AJNR. American Journal of Neuroradiology
William R Masch, Page I Wang, Thomas L Chenevert, Larry Junck, Christina Tsien, Jason A Heth, Pia C Sundgren
RATIONALE AND OBJECTIVES: To compare differences in diffusion tensor imaging (DTI) and dynamic susceptibility-weighted contrast-enhanced (DSC) magnetic resonance (MR) perfusion imaging characteristics of recurrent neoplasm and radiation necrosis in patients with brain tumors previously treated with radiotherapy with or without surgery and chemotherapy. MATERIALS AND METHODS: Patients with a history of brain neoplasm previously treated with radiotherapy with or without chemotherapy and surgery who developed a new enhancing lesion on posttreatment surveillance MRI were enrolled...
May 2016: Academic Radiology
Josep Puig, Gerard Blasco, Josep Daunis-I-Estadella, Angel Alberich-Bayarri, Marco Essig, Rajan Jain, Sebastián Remollo, David Hernández, Montserrat Puigdemont, Javier Sánchez-González, Gloria Mateu, Max Wintermark, Salvador Pedraza
INTRODUCTION: The objective of the study was to determine whether tumor-associated neovascularization on high-resolution gadofosveset-enhanced magnetic resonance angiography (MRA) is a useful biomarker for predicting survival in patients with newly diagnosed glioblastomas. METHODS: Before treatment, 35 patients (25 men; mean age, 64 ± 14 years) with glioblastoma underwent MRI including first-pass dynamic susceptibility contrast (DSC) perfusion and post-contrast T1WI sequences with gadobutrol (0...
January 2016: Neuroradiology
Pawel Szwarc, Jacek Kawa, Marcin Rudzki, Ewa Pietka
In this paper a novel multi-stage automatic method for brain tumour detection and neovasculature assessment is presented. First, the brain symmetry is exploited to register the magnetic resonance (MR) series analysed. Then, the intracranial structures are found and the region of interest (ROI) is constrained within them to tumour and peritumoural areas using the Fluid Light Attenuation Inversion Recovery (FLAIR) series. Next, the contrast-enhanced lesions are detected on the basis of T1-weighted (T1W) differential images before and after contrast medium administration...
December 2015: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
Simerpreet Bal, Mayank Goyal, Eric Smith, Andrew M Demchuk
Diabetes mellitus is an important vascular risk factor for cerebrovascular disease. This occurs through pathophysiologic changes to the microcirculation as arteriolosclerosis and to the macrocirculation as large artery atherosclerosis. Imaging techniques can provide detailed visualization of the cerebrovasculature using CT (computed tomography) angiography and MR (magnetic resonance) angiography. Newer techniques focused on advanced parenchymal imaging include CT perfusion, quantitative MRI, and diffusion tensor imaging; each identifies brain lesion burden due to diabetes mellitus...
2014: Handbook of Clinical Neurology
Cheng Hong Toh, Kuo-Chen Wei, Chen-Nen Chang, Shu-Hang Ng, Ho-Fai Wong, Ching-Po Lin
PURPOSE: To compare the diagnostic performance of dynamic susceptibility contrast-enhanced perfusion MRI before and after mathematic contrast leakage correction in differentiating pyogenic brain abscesses from glioblastomas and/or metastatic brain tumors. MATERIALS AND METHODS: Cerebral blood volume (CBV), leakage-corrected CBV and leakage coefficient K2 were measured in enhancing rims, perifocal edema and contralateral normal appearing white matter (NAWM) of 17 abscesses, 19 glioblastomas and 20 metastases, respectively...
2014: PloS One
Szilvia Erdélyi-Bótor, Mihály Aradi, David Olayinka Kamson, Norbert Kovács, Gábor Perlaki, Gergely Orsi, Szilvia Anett Nagy, Attila Schwarcz, Tamás Dóczi, Sámuel Komoly, Gabriella Deli, Anita Trauninger, Zoltán Pfund
OBJECTIVE/BACKGROUND: The aim of this longitudinal study was to investigate changes of migraine-related brain white matter hyperintensities 3 years after an initial study. Baseline quantitative magnetic resonance imaging (MRI) studies of migraine patients with hemispheric white matter hyperintensities performed in 2009 demonstrated signs of tissue damage within the hyperintensities. The hyperintensities appeared most frequently in the deep white matter of the frontal lobe with a similar average hyperintensity size in all hemispheric lobes...
January 2015: Headache
H N Jung, S T Kim, J Cha, H J Kim, H S Byun, P Jeon, K H Kim, B-J Kim, H-J Kim
BACKGROUND AND PURPOSE: Developmental venous anomalies are the most common intracranial vascular malformation. Increased signal-intensity on T2-FLAIR images in the areas drained by developmental venous anomalies are encountered occasionally on brain imaging studies. We evaluated diffusion and perfusion MR imaging findings of the abnormally high signal intensity associated with developmental venous anomalies to describe their pathophysiologic nature. MATERIALS AND METHODS: We retrospectively reviewed imaging findings of 34 subjects with signal-intensity abnormalities associated with developmental venous anomalies...
August 2014: AJNR. American Journal of Neuroradiology
Valdeci Hélio Floriano, Ulysses S Torres, Antonio Ronaldo Spotti, José Roberto Lopes Ferraz-Filho, Waldir Antônio Tognola
BACKGROUND AND PURPOSE: Differentiating between infectious and neoplastic focal brain lesions that are detected by conventional structural magnetic resonance imaging (MRI) may be a challenge in routine practice. Brain perfusion-weighted MRI (PWI) may be employed as a complementary non-invasive tool, providing relevant data on hemodynamic parameters, such as the degree of angiogenesis of lesions. We aimed to employ dynamic susceptibility contrast-enhanced perfusion MR imaging (DSC-MRI) to differentiate between infectious and neoplastic brain lesions by investigating brain microcirculation changes...
2013: PloS One
Young Jun Choi, Ho Sung Kim, Geon-Ho Jahng, Sang Joon Kim, Dae Chul Suh
BACKGROUND: Pseudoprogression is a treatment-related reaction with an increase in contrast-enhancing lesion size, followed by subsequent improvement. Differentiating tumor recurrence from pseudoprogression remains a problem in neuro-oncology. PURPOSE: To validate the added value of arterial spin labeling (ASL), compared with dynamic susceptibility contrast (DSC) perfusion magnetic resonance imaging (MRI) alone, in distinguishing early tumor progression from pseudoprogression in patients with newly diagnosed glioblastoma multiforme (GBM)...
May 2013: Acta Radiologica
Christopher L H Chen, Kamran Ikram, Qiu Anqi, Wong Tien Yin, Annabel Chen, Narayanaswamy Venketasubramanian
BACKGROUND: A substantial proportion of patients after nondisabling stroke are cognitively impaired compared to age- and education-matched community-dwelling controls. Moreover, poststroke patients who have 'vascular cognitive impairment no dementia' (VCIND) of moderate severity have a high risk of incident dementia, dependency and death. Further studies are urgently needed to demonstrate effective cognition-enhancing therapies in VCIND given the scarcity of evidence-based treatment options...
2013: Cerebrovascular Diseases
Jessica A Wilden, Jason Voorhies, Kristine M Mosier, Darren P O'Neill, Aaron A Cohen-Gadol
OBJECT: Early and aggressive resection of low-grade gliomas (LGGs) leads to increased overall patient survival, decreased malignant progression, and better seizure control. This case series describes the authors' approach to achieving optimal neurological and surgical outcomes in patients referred by outside neurosurgeons for stereotactic biopsy of tumors believed to be complex or a high surgical risk, due to their diffuse nature on neuroimaging and their obvious infiltration of functional cortex...
February 2013: Neurosurgical Focus
M Hohenhaus, W U Schmidt, P Brunecker, C Xu, B Hotter, M Rozanski, J B Fiebach, G J Jungehülsing
BACKGROUND: Vascular hyperintensities of brain-supplying arteries on stroke FLAIR MRI are common and represent slow flow or stasis. FLAIR vascular hyperintensities (FVH) are discussed as an independent marker for cerebral hypoperfusion, but the impact on infarct size and clinical outcome in acute stroke patients is controversial. This study evaluates the association of FVH with infarct morphology, clinical stroke severity and infarct growth in patients with symptomatic internal carotid artery (ICA) or middle cerebral artery (MCA) occlusion...
2012: Cerebrovascular Diseases
S Gaudino, G M Di Lella, R Russo, V S Lo Russo, F Piludu, F R Quaglio, M R Gualano, C De Waure, C Colosimo
PURPOSE: This study was done to investigate the usefulness of diffusion-weighted (DWI), perfusion-weighted (PWI) and proton magnetic resonance (MR) spectroscopy imaging in characterising solitary brain metastases. MATERIALS AND METHODS: Fifty-nine solitary brain metastases were evaluated with conventional and nonmorphological MR imaging: DWI, PWI and MR spectroscopy. We evaluated size, signal intensity and contrast enhancement and calculated apparent diffusion coefficient (ADC), relative cerebral blood volume (rCBV), percentage of signal intensity recovery (PSR) and maximum values of N-acetylaspartate (NAA), choline (Cho), creatine (Cr), lipids (Lip), NAA/Cr and Cho/Cr...
October 2012: La Radiologia Medica
I Makedonov, S E Black, B J MacIntosh
BACKGROUND: White matter hyperintensities (WMH) are associated with aging and are prevalent in various brain pathologies. The purpose of the current study was to characterize WMH perfusion in age-matched elderly controls (ECs) and patients with Alzheimer's disease (ADs). METHODS: Fifty ECs (23 men) and 61 ADs (33 men) underwent magnetic resonance imaging (MRI), 99mTc-ECD single-photon emission computed tomography (SPECT) and cognitive testing. Brain tissue type was classified on T1 weighted images, and WMH were identified on interleaved proton density/T2 weighted images...
February 2013: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
Vivek Prabhakaran, Veena A Nair, Benjamin P Austin, Christian La, Thomas A Gallagher, Yijing Wu, Donald G McLaren, Guofan Xu, Patrick Turski, Howard Rowley
There are several magnetic resonance (MR) imaging techniques that benefit from high-field MR imaging. This article describes a range of novel techniques that are currently being used clinically or will be used in the future for clinical purposes as they gain popularity. These techniques include functional MR imaging, diffusion tensor imaging, cortical thickness assessment, arterial spin labeling perfusion, white matter hyperintensity lesion assessment, and advanced MR angiography.
May 2012: Neuroimaging Clinics of North America
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