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Acute severe pancreatitis

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https://www.readbyqxmd.com/read/29345595/hospital-management-of-severe-hypertriglyceridemia-in-children
#1
Ambika Ashraf, Badhma Valaiyapathi
Severe hypertriglyceridemia (HTG), i.e., triglyceride levels exceeding 1000 mg/dL, is one of the established causes of acute pancreatitis and severe abdominal pain. There are no established pediatric guidelines for treatment of children and adolescents with severe HTG. Management often includes hospital admission, fasting followed by fat free diet until the triglyceride (TG) levels are below 1000 mg/dL. Insulin infusion lowers TG levels in patients, especially in those with diabetes. Plasmapheresis is a limited option due to its restricted availability and scarcity of studies on its efficacy and safety in children...
January 16, 2018: Current Pediatric Reviews
https://www.readbyqxmd.com/read/29341114/recombinant-human-hepatocyte-growth-factor-provides-protective-effects-in-celurein-induced-acute-pancreatitis-in-mice
#2
Mayrel Palestino-Domínguez, Mario Pelaez-Luna, Roberto Lazzarini-Lechuga, Ignacio Rodríguez-Ochoa, Verónica Souza, Roxana U Miranda, Benjamín Pérez-Aguilar, Leticia Bucio, Jens U Marquardt, Luis Enrique Gomez-Quiroz, María Concepción Gutiérrez-Ruiz
Acute pancreatitis is a multifactorial disease associated with profound changes of the pancreas induced by release of digestive enzymes that lead to increase in proinflammatory cytokine production, excessive tissue necrosis, edema, and bleeding. Elevated levels of hepatocyte growth factor (HGF) and its receptor c-Met have been observed in different chronic and acute pancreatic diseases including experimental models of acute pancreatitis. In the present study, we investigated the protective effects induced by the recombinant human HGF in a mouse model of cerulein-induced acute pancreatitis...
January 17, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29340918/validation-of-aast-egs-grade-for-acute-pancreatitis
#3
Moustafa Younis, Matthew Hernandez, Mohamed Ray-Zack, Nadeem N Haddad, Asad Choudhry, Pooja Reddy, Martin D Zielinski
BACKGROUND: The AAST recently developed an emergency general surgery (EGS) disease grading system to measure anatomic severity. We aimed to validate this grading system for acute pancreatitis and compare cross sectional imaging-based AAST EGS grade and compare with several clinical prediction models. We hypothesize that increased AAST EGS grade would be associated with important physiological and clinical outcomes and is comparable to other severity grading methods. METHODS: Single institution retrospective review of adult patients admitted with acute pancreatitis during 10/2014-1/2016 was performed...
January 16, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29332096/higher-thrombin-antithrombin-iii-complex-levels-may-indicate-severe-acute-pancreatitis
#4
Sami Fidan, Murat Erkut, Arif Mansur Cosar, Yasar Yogun, Asım Örem, Mehmet Sönmez, Mehmet Arslan
AIM: Coagulation disorders may develop in association with severe acute pancreatitis (AP). Plasma thrombin-antithrombin III complex (TAT) levels are one of the principal markers of coagulation disorder. The purpose of this study was to evaluate TAT and other hemostatic parameters in patients with AP and to examine whether or not these parameters indicate the severity of AP. METHOD: Forty-six patients with AP (14 severe, 32 non-severe) and a 30-member healthy control group were recruited...
January 12, 2018: Digestive Diseases
https://www.readbyqxmd.com/read/29330618/oleic-acid-chlorohydrin-a-new-early-biomarker-for-the-prediction-of-acute-pancreatitis-severity-in-humans
#5
Enrique de-Madaria, Xavier Molero, Laia Bonjoch, Josefina Casas, Karina Cárdenas-Jaén, Andrea Montenegro, Daniel Closa
BACKGROUND: The early prediction of the severity of acute pancreatitis still represents a challenge for clinicians. Experimental studies have revealed the generation of specific halogenated lipids, in particular oleic acid chlorohydrin, in the early stages of acute pancreatitis. We hypothesized that the levels of circulating oleic acid chlorohydrin might be a useful early prognostic biomarker in acute pancreatitis in humans. METHODS: In a prospective, multicenter cohort study, plasma samples collected within 24 h after presentation in the emergency room from 59 patients with acute pancreatitis and from 9 healthy subjects were assessed for oleic acid chlorohydrin levels...
January 9, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29328945/astaxanthin-ameliorates-cerulein-induced-acute-pancreatitis-in-mice
#6
Hui Zhang, Wenjuan Yang, Yueyue Li, Liangkai Hu, Ying Dai, Jianqing Chen, Shuqi Xu, Xuanfu Xu, Haiqiong Jiang
BACKGROUND: A various of pharmacological effects of astaxanthin has been confirmed. However, the mechanism underlying protective effect of astaxanthin on acute pancreatitis (AP) induced by cerulein still unclear. The present study is to investigate the mechanism underlying the effect of astaxanthin on autophagy and apoptosis via the JAK/STAT3 pathway. METHODS: Intraperitoneal injection of cerulein at hourly intervals followed by lipopolysaccharide injection were used in Balb/C mice...
January 9, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29325893/stilamin-inhibits-intestinal-and-pancreatic-injury-in-rats-with-severe-acute-pancreatitis-by-down-regulating-lcn2-expression
#7
Yifan Ren, Qing Cui, Jianbin Bi, Zhaoqing Du, Jia Zhang, Xufeng Zhang, Yi Lv, Rongqian Wu
OBJECTIVE: This study was aimed at exploring the function and mechanism of Stilamin on severe acute pancreatitis (SAP) in rats. METHODS: We analyzed the histology of small intestine and pancreatic tissues of SAP rats and SAP rats plus treatment with Stilamin. The expression levels of IL-6 and TNF-α in serum were detected using ELISA. The expressions of Caspase-3, bcl-2, Bax and p53 in rat tissues of SAP group were verified by qRT-PCR and western blot. The differential expressed mRNAs in rats of SAP group were screened out by microarray analysis...
January 2, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29324628/ulinastatin-protects-against-lps-induced-acute-lung-injury-by-attenuating-tlr4-nf-%C3%AE%C2%BAb-pathway-activation-and-reducing-inflammatory-mediators
#8
Chao Cao, Chengfen Yin, Songtao Shou, Jun Wang, Lechang Yu, Xuening Li, Yanfen Chai
Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), remain the leading causes of morbidity and mortality in intensive care units. Ulinastatin (UTI), a serine protease inhibitor, possesses anti-inflammatory properties and has been suggested to modulate lipopolysaccharide (LPS)-induced sepsis; thus, it is now widely used in the treatment of pancreatitis, sepsis, and septic shock. Toll-like receptor 4 (TLR4), an essential LPS signaling receptor, plays a critical role in the activation of innate immunity...
January 10, 2018: Shock
https://www.readbyqxmd.com/read/29318362/an-immunocapture-lc-ms-based-assay-for-serum-spink1-allows-simultaneous-quantification-and-detection-of-spink1-variants
#9
Suvi Ravela, Leena Valmu, Mykola Domanskyy, Hannu Koistinen, Leena Kylänpää, Outi Lindström, Jakob Stenman, Esa Hämäläinen, Ulf-Håkan Stenman, Outi Itkonen
Pancreatic secretory trypsin inhibitor Kazal type 1 (SPINK1) is a 6420 Da peptide produced by the pancreas, but also by several other tissues and many tumors. Some mutations of the SPINK1 gene, like the one causing amino acid change N34S, have been shown to confer susceptibility to recurrent or chronic pancreatitis. Detection of such variants are therefore of clinical utility. So far SPINK1 variants have been determined by DNA techniques. We have developed and validated an immunocapture-liquid chromatography-mass spectrometric (IC-LC-MS) assay for the detection and quantification of serum SPINK1, N34S-SPINK1, and P55S-SPINK1...
January 9, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29312869/gastrointestinal-tract-involvement-in-acute-pancreatitis-initial-findings-and-follow-up-by-magnetic-resonance-imaging
#10
Yi-Fan Ji, Xiao-Ming Zhang, Don G Mitchell, Xing-Hui Li, Tian-Wu Chen, Yong Li, Zhi-Guo Bao, Wei Tang, Bo Xiao, Xiao-Hua Huang, Lin Yang
Background: To study the initial and follow up patterns of gastrointestinal tract involvement in acute pancreatitis (AP) using magnetic resonance imaging (MRI). Methods: A total of 209 patients with AP undergoing abdominal MRI on 1.5 T MRI were compared to 100 control patients selected from our daily clinical caseload who underwent MRI over the same recruitment period and had no other disease which can cause abnormality of gastrointestinal tract. Initial and follow up MRI examinations of gastrointestinal tract abnormalities were noted for AP patients...
December 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29311029/recurrent-biliary-acute-pancreatitis-is-frequent-in-a-real-world-setting
#11
Serena Stigliano, Flaminia Belisario, Matteo Piciucchi, Marianna Signoretti, Gianfranco Delle Fave, Gabriele Capurso
BACKGROUND: Data about recurrent acute pancreatitis (RAP) are limited. AIMS: To evaluate the rate of RAP and associated factors. METHODS: Single-centre prospective study of consecutive patients at first episode of acute pancreatitis (AP) being followed-up. RESULTS: Of 266 consecutive AP patients, (47% biliary, 15.4% alcoholic, 14.3% idiopathic) 66 (24.8%) had RAP in a mean follow-up of 42 months; 17.9% of recurrences occurred within 30 days from discharge...
December 19, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29310417/interleukin-10-gene-rs1800896-polymorphism-increases-risk-of-acute-pancreatitis
#12
Hongmei Zhou, Ailing Liu, Bingzhi Zhou, Cunxin Zhao, Guangjun Jin
BACKGROUND: The association between interleukin-10 (IL-10) gene rs1800896 polymorphism and susceptibility to acute pancreatitis (AP) has been investigated in several studies, but with contradictory findings. Therefore, a comprehensive meta-analysis is needed to assess the strength of such association. METHODS: Literatures on PubMed, EMBASE, and CNKI were searched to identify relevant studies. The strength of association between IL-10 gene rs1800896 polymorphism and AP risk was assessed using pooled odds ratios and 95% confidence intervals...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29310378/isolated-cerebral-aspergillosis-in-an-immunocompetent-woman-on-treatment-for-bacterial-infected-necrotizing-pancreatitis-a-case-report
#13
Shaoyang Zhang, Qinghui Fu, Qi Chen, Ting-Bo Liang
RATIONALE: Cerebral aspergillosis (CA) is a rare manifestation of invasive aspergillosis. It usually affects seriously immunocompromised hosts. Pancreatic bacterial or/and fungal infection is common in patients with severe acute pancreatitis. PATIENT CONCERNS: We report the first case of an immunocompetent woman with infected necrotizing pancreatitis due to multidrug resistant Acinetobacter baumannii who, in the course of treatment, developed isolated CA. DIAGNOSES: Magnetic resonance imaging, rather than computed tomography, revealed latent homolateral sinus disease-the possible source of the Aspergillus infection...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29305366/vedolizumab-induced-acute-pancreatitis-the-first-reported-clinical-case
#14
Sherman Picardo, Kenji So, Kannan Venugopal, Marcus Chin
Drug-induced acute pancreatitis (DIAP) is a rare, but clinically significant diagnosis. Vedolizumab, an α4β7 integrin inhibitor, which was approved in 2015 for treatment of moderate to severe inflammatory bowel disease, is a well-tolerated medication with a favourable safety profile and minimal serious adverse events in premarketing clinical trials. We present the first reported case of acute pancreatitis directly attributable to vedolizumab.
January 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29303910/involvement-of-nucleotide-binding-and-oligomerization-domain-like-receptors-in-the-intestinal-injury-of-severe-acute-pancreatitis-in-rats
#15
Shan Xu, Shuqing Wei, Yu Guo, Donglai Cui, Jinfeng Yao
OBJECTIVES: The aim of the study was to observe the role of nucleotide-binding and oligomerization domain (NOD)-like receptors (NLR) in intestine injury of severe acute pancreatitis (SAP) in rats. METHODS: Severe acute pancreatitis was induced by retrograde infusion of sodium taurocholate into the biliopancreatic duct. Rats were divided into the following 6 groups: sham operation, SAP treated with saline, and SAP treated with interleukin 1β (IL-1β)-converting enzyme inhibitor, killed at 6 or 12 hours after operation...
January 5, 2018: Pancreas
https://www.readbyqxmd.com/read/29289538/omega-3-carboxylic-acids-in-patients-with-severe-hypertriglyceridemia-evolve-ii-a-randomized-placebo-controlled-trial
#16
Erik S G Stroes, Andrey V Susekov, Tjerk W A de Bruin, Mats Kvarnström, Hong Yang, Michael H Davidson
BACKGROUND: Adult patients with severe hypertriglyceridemia (SHTG) are at increased risk of developing acute pancreatitis and cardiovascular disease. Omega-3 carboxylic acids (OM3-CA) are approved for treatment as an adjunct to diet to reduce triglyceride (TG) concentrations in patients with SHTG. OBJECTIVE: The aim of the study was to assess efficacy and safety of the intermediate dose of OM3-CA (2 g daily), compared with olive oil 2 g daily, in reducing serum TG and lipid concentrations in patients with SHTG...
October 27, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29287582/acute-pancreatitis-a-rare-but-serious-complication-for-living-liver-donors-risk-factors-and-outcomes
#17
Adil Baskiran, Metin Kement, Bora Barut, Oguzhan Ozsay, Serdar Karakas, Cemalettin Koç, Sezai Yilmaz
OBJECTIVES: The purposes of this study were to determine the incidence of acute pancreatitis after living donor hepatectomy and to investigate potential risk factors and outcomes. MATERIALS AND METHODS: Clinical data of all donors who underwent donor hepatectomy between January 2015 and December 2016 in our liver transplant institute were reviewed. Donor data were obtained from a prospectively maintained database. The donors were divided into 2 groups according to whether they developed postoperative pancreatitis...
December 29, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29285795/ataluren-driven-restoration-of-shwachman-bodian-diamond-syndrome-protein-function-in-shwachman-diamond-syndrome-bone-marrow-cells
#18
Valentino Bezzerri, Donatella Bardelli, Jacopo Morini, Antonio Vella, Simone Cesaro, Claudio Sorio, Andrea Biondi, Cesare Danesino, Piero Farruggia, Baroukh Maurice Assael, Giovanna D'Amico, Marco Cipolli
Shwachman-Diamond syndrome (SDS) is a rare inherited recessive disease mainly caused by mutations in the Shwachman-Bodian-Diamond syndrome (SBDS) gene, which encodes for the homonymous protein SBDS, whose function still remains to be fully established. SDS affects several organs causing bone marrow failure, exocrine pancreatic insufficiency, skeletal malformations, and cognitive disorders. About 15% of SDS patients develop myelodysplastic syndromes (MDS) and are at higher risk of developing acute myeloid leukemia (AML)...
December 29, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/29285688/pancreatoblastoma-an-unusual-diagnosis-in-an-adult-patient
#19
Gonçalo Nunes, Hélder Coelho, Marta Patita, Rita Barosa, Pedro Pinto Marques, Lídia Roque Ramos, Maria José Brito, Aurora Tomaz, Jorge Fonseca
The authors describe a 31-year-old man admitted due to progressive weight loss, diarrhea and massive hepatomegaly. Laboratory data showed anemia (haemoglobin 11.7 g/dl), abnormal liver tests (total bilirubin 1.4 g/dl, aspartate aminotransferase 70 U/l, alanine aminotransferase 37 U/l and alkaline phosphatase 520 U/l). Abdominal ultrasound (US) displayed a large heterogeneous liver with a segment IV 25 mm nodule. Magnetic resonance revealed a 4 cm pancreatic tail mass and several liver nodules consistent with metastasis...
December 28, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29281757/short-term-outcomes-and-risk-factors-for-pancreatic-fistula-after-pancreatic-enucleation-a-single-center-experience-of-142-patients
#20
Xing Wang, Chun-Lu Tan, Hao Zhang, Yong-Hua Chen, Min Yang, Neng-Wen Ke, Xu-Bao Liu
BACKGROUND: Enucleation is increasingly used for benign or low-grade pancreatic neoplasms. Enucleation preserves the pancreatic parenchyma as well as decreases the risk of long-term endocrine and exocrine dysfunction, but may be associated with a higher rate of postoperative pancreatic fistula (POPF). The aim of this study was to assess short-term outcomes, in particular, POPF. METHODS: Data were collected retrospectively from all 142 patients who underwent pancreatic enucleation between 2009 and 2014 in our institution were analyzed...
December 27, 2017: Journal of Surgical Oncology
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