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wheezing in infant and children

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https://www.readbyqxmd.com/read/28822439/-multisystemic-smooth-muscle-dysfunction-syndrome-in-children-a-case-report-and-literature-review
#1
Y L Zhou, Y Y Zhang, B L Cheng, D Xu, L F Tang, Z M Chen
Objective: To analyze the clinical characteristics and diagnosis of multisystemic smooth muscle dysfunction syndrome(MSMDS). Method: Clinical data of a case diagnosed as MSMDS and hospitalized in our hospital in July 2016 was retrospectively analyzed. Literature search was performed at databases of PubMed, Wanfang, China National Knowledge Infrastructure and VIP with the key words "multisystemic smooth muscle dysfunction syndrome" "ACTA2" . The literature retrieval was confined from January 1980 to November 2016...
August 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28757230/vitamin-d-high-sensitivity-c-reactive-protein-and-airway-hyperresponsiveness-in-infants-with-recurrent-respiratory-symptoms
#2
Anette M Määttä, Anne Kotaniemi-Syrjänen, Kristiina Malmström, L Pekka Malmberg, Jouko Sundvall, Anna S Pelkonen, Mika J Mäkelä
BACKGROUND: Vitamin D insufficiency might be associated with biased T-cell responses resulting in inflammatory conditions such as atopy and asthma. Little is known about the role of vitamin D in low-grade systemic inflammation and airway hyperresponsiveness (AHR) in young children. OBJECTIVE: To evaluate whether vitamin D insufficiency and increased serum high-sensitivity C-reactive protein (hs-CRP) are linked to AHR in symptomatic infants. METHODS: Seventy-nine infants with recurrent or persistent lower respiratory tract symptoms underwent comprehensive lung function testing and a bronchial methacholine challenge test...
July 28, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28754005/can-early-omega-3-fatty-acid-exposure-reduce-risk-of-childhood-allergic-disease
#3
REVIEW
Elizabeth A Miles, Philip C Calder
A causal link between increased intake of omega-6 (n-6) polyunsaturated fatty acids (PUFAs) and increased incidence of allergic disease has been suggested. This is supported by biologically plausible mechanisms, related to the roles of eicosanoid mediators produced from the n-6 PUFA arachidonic acid. Fish and fish oils are sources of long chain omega-3 (n-3) PUFAs. These fatty acids act to oppose the actions of n-6 PUFAs particularly with regard to eicosanoid synthesis. Thus, n-3 PUFAs may protect against allergic sensitisation and allergic manifestations...
July 21, 2017: Nutrients
https://www.readbyqxmd.com/read/28695368/an-interaction-of-lps-and-rsv-infection-in-augmenting-the-ahr-and-airway-inflammation-in-mice
#4
Na Zhou, Wei Li, Luo Ren, Xiaohong Xie, Enmei Liu
Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory tract infection (LRTI) in children under 5 years of age, especially infants with severe bronchiolitis. Our preliminary clinical experiments showed that bacterial colonization was commonly observed in children with virus-induced wheezing, particularly in those with recurrent wheezing, suggesting that bacterial colonization with an accompanying viral infection may contribute to disease severity. In most cases, RSV-infected infants were colonized with pathogenic bacteria (mainly Gram-negative bacteria)...
July 10, 2017: Inflammation
https://www.readbyqxmd.com/read/28675776/vitamin-d-supplementation-in-primary-allergy-prevention-systematic-review-of-randomized-and-non-randomized-studies
#5
REVIEW
Juan José Yepes-Nuñez, Jan L Brożek, Alessandro Fiocchi, Ruby Pawankar, Carlos Cuello-García, Yuan Zhang, Gian Paolo Morgano, Arnav Agarwal, Shreyas Gandhi, Luigi Terracciano, Holger J Schünemann
BACKGROUND: To date, a systematic review of the evidence regarding the association between Vitamin D and allergic diseases development has not yet been undertaken. OBJECTIVE: To review the efficacy and safety of Vitamin D supplementation when compared to no supplementation in pregnant women, breastfeeding women, infants and children for the prevention of allergies. METHODS: Three databases were searched through 30 January 2016 including randomized (RCT) and non-randomized studies (NRS)...
July 4, 2017: Allergy
https://www.readbyqxmd.com/read/28646967/the-respiratory-microbiome-and-respiratory-infections
#6
Stefan A Unger, Debby Bogaert
Despite advances over the past ten years lower respiratory tract infections still comprise around a fifth of all deaths worldwide in children under five years of age with the majority in low- and middle-income countries. Known risk factors for severe respiratory infections and poor chronic respiratory health do not fully explain why some children become sick and others do not. The respiratory tract hosts bacteria that can cause respiratory infections but also normal commensal bacteria. Together, this microbial population is called the microbiome...
June 2017: Journal of Infection
https://www.readbyqxmd.com/read/28633906/rsv-in-adult-ed-patients-do-emergency%C3%A2-providers-consider-rsv-as-an-admission-diagnosis
#7
William Binder, Jill Thorsen, Pierre Borczuk
BACKGROUND: Respiratory Syncytial Virus (RSV) has been recognized for over half a century as a cause of morbidity in infants and children. Over the past 20years, data has emerged linking RSV as a cause of illness in adults resulting in 177,000 annual hospitalizations and up to 14,000 deaths among older adults. OBJECTIVE: Characterize clinical variables in a cohort of adult RSV patients. We hypothesize that emergency physicians do not routinely consider RSV in the differential diagnosis (DDx) of influenza like illness...
August 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28629669/influence-of-the-mediterranean-diet-during-pregnancy-in-the-development-of-wheezing-and-eczema-in-infants-in-pamplona-spain
#8
N Alvarez Zallo, I Aguinaga-Ontoso, I Alvarez-Alvarez, B Marin-Fernandez, F Guillén-Grima, C Azcona-San Julián
BACKGROUND: This study examined the relationship between different food groups and the adherence to a Mediterranean diet during pregnancy and the risk of wheezing and eczema in children aged 12-15 months. METHODS: The study involves 1087 Spanish infants from the International Study of Wheezing in Infants (Estudio Internacional de Sibilancias en Lactantes, EISL). The study of the association of the different food consumption and Mediterranean diet with wheezing, recurrent wheezing and eczema was performed using different models of unconditional logistic regression to obtain adjusted prevalence odds ratios (OR) and 95% confidence intervals (95% CI)...
June 16, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28601031/delayed-diagnosis-of-esophageal-foreign-body-a-case-report
#9
Salem Yahyaoui, Imen Jahaouat, Ines Brini, Azza Sammoud
INTRODUCTION: Foreign body (FB) ingestion, a common and serious problem in children, can present with a wide variety of symptoms. This paper describes and discusses the case of an esophageal foreign body (EFB), in which the patient presented with primarily respiratory clinical signs causing delayed diagnosis. PRESENTATION OF CASE: A six month old boy presented with three months history of harsh cough, stridor and pulmonary congestion. He was repeatedly treated with steroids and antibiotics...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28580865/the-association-between-environmental-tobacco-smoke-exposure-and-childhood-respiratory-disease-a-review
#10
A Vanker, R P Gie, H J Zar
Childhood respiratory illness is a major cause of morbidity and mortality particularly in low and middle-income countries. Environmental tobacco smoke (ETS) exposure is a recognised risk factor for both acute and chronic respiratory illness. Areas covered: The aim of this paper was to review the epidemiology of ETS exposure and impact on respiratory health in children. We conducted a search of 3 electronic databases of publications on ETS and childhood respiratory illness from 1990-2015. Key findings were that up to 70% of children are exposed to ETS globally, but under-reporting may mask the true prevalence...
August 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/28571896/-short-term-relevance-of-lower-respiratory-viral-coinfection-in-inpatients-under-2-years-of-age
#11
Joana Gil, Sofia Almeida, Carolina Constant, Sara Pinto, Rosário Barreto, José Melo Cristino, Maria do Céu Machado, Teresa Bandeira
INTRODUCTION: Advances in molecular diagnosis have made it possible to detect previously unknown viral agents as causative agents of lower respiratory tract infections (LRTI). The frequency and relevance of viral coinfections is still debatable. OBJECTIVE: compare clinical presentation and severity between single virus infection and viral coinfection in children admitted for LRTI. METHODS: A 3-year period observational study (2012-2015) included children younger than two years admitted for LRTI...
May 29, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/28544041/marked-variability-observed-in-inpatient-management-of-bronchiolitis-in-three-finnish-hospitals
#12
Varpu Elenius, Eija Bergroth, Petri Koponen, Sami Remes, Pedro A Piedra, Janice A Espinola, Matti Korppi, Carlos A Camargo, Tuomas Jartti
AIM: Infants hospitalised for bronchiolitis undergo examinations and treatments not supported by current research evidence and we investigated practice variations with regard to Finnish children under the age of two. METHODS: This prospective, multicentre cohort study was conducted in paediatric units in three university hospitals in Finland from 2008 to 2010. Hospital medical records were reviewed to collect data on clinical course, testing and treatment. Data were analysed separately for children meeting our strict definition of bronchiolitis, aged under 12 months without a history of wheezing, and a loose definition, aged 12-23 months or with a history of wheezing...
May 24, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28507765/asthma-epidemiology-of-disease-control-in-latin-america-short-review
#13
REVIEW
Dirceu Solé, Carolina Sanchez Aranda, Gustavo Falbo Wandalsen
Asthma is reported as one of the most common chronic diseases in childhood, impairing the quality of life of patients and their families and incurring high costs to the healthcare system and society. Despite the development of new drugs and the availability of international treatment guidelines, asthma is still poorly controlled, especially in Latin America. Original and review articles on asthma control or epidemiology with high levels of evidence have been selected for analysis among those published in PubMed referenced journals during the last 20 years, using the following keywords: "asthma control" combined with "Latin America", " epidemiology", "prevalence", "burden", "mortality", "treatment and unmet needs", "children", "adolescents", and "infants"...
2017: Asthma research and practice
https://www.readbyqxmd.com/read/28503824/an-index-to-predict-asthma-in-wheezing-young-children-produced-promising-initial-results
#14
Bill Hesselmar, Robert Saalman, Göran Wennergren, Mainor Åmark, Agnes E Wold, Ingegerd Adlerberth, Nils Åberg
No abstract text is available yet for this article.
May 15, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28500974/ongoing-developments-in-rsv-prophylaxis-a-clinician-s-analysis
#15
REVIEW
Fariba Rezaee, Debra T Linfield, Terri J Harford, Giovanni Piedimonte
Respiratory syncytial virus (RSV) is the most common respiratory pathogen in infants and young children worldwide. Lower respiratory tract infection due to RSV is one of the most common causes of hospitalization for infants, especially those born premature or with chronic lung or heart disease. Furthermore, RSV infection is an important cause of morbidity in adults, particularly in the elderly and immunocompromised individuals. The acute phase of this infection is often followed by episodes of wheezing that recur for months or years and usually lead to a physician diagnosis of asthma...
June 2017: Current Opinion in Virology
https://www.readbyqxmd.com/read/28497673/body-mass-index-and-skin-reactivity-to-histamine-and-dermatophagoides-pteronyssinus-in-children-and-adolescents-followed-in-a-pediatric-allergy-service
#16
A Keller Franco, R Oselka Sarni, M Carvalho Mallozi, D Solé
Rationale. Recent data suggest that the nutritional status assessed by body mass index (BMI) is positively associated with skin reactivity to histamine in children. Objective. To study the relation between BMI and skin reactivity to histamine and Dermatophagoides pteronyssinus in allergic children and adolescents. Methods. The medical charts of patients attended in our outpatient clinic between 2013 and 2014 (n = 972) were evaluated. Only patients with asthma, allergic rhinitis or wheezing infants sensitized to at least one aeroallergen were selected: a total of 626 patients (6 months to 19 year-olds; 60...
May 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28480848/acute-viral-bronchiolitis-in-infants-review
#17
REVIEW
I Chkhaidze, D Zirakishvili
Bronchiolitis is a common condition in children less than 2 years of age and is a leading cause of infant hospitalization. Acute bronchiolitis is characterized by acute wheezing in infants or children and is associated with signs or symptoms of respiratory infection; the most common etiologic agent is respiratory syncytial virus. There is a lack of consensus regarding the clinical definition of acute viral bronchiolitis in children and hence the management varies across the globe. Usually it does not require investigation, treatment is merely supportive and a conservative approach seems adequate in the majority of children, especially for the youngest ones...
March 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28339145/respiratory-syncytial-virus-host-interaction-in-the-pathogenesis-of-bronchiolitis-and-its-impact-on-respiratory-morbidity-in-later-life
#18
REVIEW
Giovanni A Rossi, Andrew A Colin
Respiratory syncytial virus (RSV) is the most common agent of severe airway disease in infants and young children. Large epidemiologic studies have demonstrated a clear relationship between RSV infection and subsequent recurrent wheezing and asthma into childhood, thought to be predominantly related to long-term changes in neuroimmune control of airway tone rather than to allergic sensitization. These changes appear to be governed by the severity of the first RSV infection in infancy which in term depends on viral characteristics and load, but perhaps as importantly, on the genetic susceptibility and on the constitutional characteristic of the host...
June 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28336364/mechanisms-and-roles-by-which-irf-3-mediates-the-regulation-of-ormdl3-transcription-in-respiratory-syncytial-virus-infection
#19
Xiao-Hua Wang, Jin Shu, Chun-Ming Jiang, Li-Li Zhuang, Wei-Xia Yang, Hui-Weng Zhang, Lu-Lu Wang, Lin Li, Xiao-Qing Chen, Rui Jin, Guo-Ping Zhou
Respiratory syncytial virus (RSV) is the leading cause of bronchiolitis in infancy, which is a major risk factor for recurrent wheezing and asthma. Orosomucoid 1-like protein 3 (ORMDL3) has been reported to associate with virus-triggered recurrent wheezing and asthma in children. However, little is known about how ORMDL3 is involved into RSV infection. In this study, we showed that the mRNA expression of ORMDL3 is significantly increased in the peripheral blood lymphocytes of infants with RSV-induced bronchiolitis compared with uninfected controls, also increased in bronchial epithelial cells and lung fibroblasts following RSV infection in vitro...
March 20, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28306160/new-approach-shows-no-association-between-maternal-milk-fatty-acid-composition-and-childhood-wheeze-or-asthma
#20
C A Logan, S Brandt, M Wabitsch, H Brenner, F Wiens, B Stahl, T Marosvölgyi, T Decsi, D Rothenbacher, J Genuneit
BACKGROUND: Previous observational studies have implied breastmilk fatty acid composition may play a role in the development of atopic eczema or atopic sensitization in breastfed infants and toddlers. However, studies investigating associations with wheeze and asthma in later childhood are scarce and did not account for inherent correlation of compositional data. Our aim was to explore the association of maternal milk fatty acid composition with childhood wheezing phenotypes and asthma up to age 13 years using a new statistical approach...
September 2017: Allergy
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