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wheezing in infant and children

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https://www.readbyqxmd.com/read/29664908/a-new-model-of-wheezing-severity-in-young-children-using-the-validated-isaac-wheezing-module-a-latent-variable-approach-with-validation-in-independent-cohorts
#1
Steven M Brunwasser, Tebeb Gebretsadik, Diane R Gold, Kedir N Turi, Cosby A Stone, Soma Datta, James E Gern, Tina V Hartert
BACKGROUND: The International Study of Asthma and Allergies in Children (ISAAC) Wheezing Module is commonly used to characterize pediatric asthma in epidemiological studies, including nearly all airway cohorts participating in the Environmental Influences on Child Health Outcomes (ECHO) consortium. However, there is no consensus model for operationalizing wheezing severity with this instrument in explanatory research studies. Severity is typically measured using coarsely-defined categorical variables, reducing power and potentially underestimating etiological associations...
2018: PloS One
https://www.readbyqxmd.com/read/29655864/comparison-of-the-severity-of-respiratory-disease-in-children-testing-positive-for-enterovirus-d68-and-human-rhinovirus
#2
Esra Caylan, Ezra Weinblatt, John Welter, Allen Dozor, Guiqing Wang, Sheila M Nolan
OBJECTIVE: To compare the characteristics and severity of respiratory disease in children testing positive for enterovirus D68 (EV-D68) and for human rhinovirus (RhV). STUDY DESIGN: A retrospective single center study of children presenting with acute respiratory symptoms and positive polymerase chain reaction for RhV/EV from September 1, 2014 through October 31, 2014 was performed. Specimens were subsequently tested specifically for EV-D68 and specimens identified as RhV were subtyped when possible into RhV-A, RhV-B, and RhV-C species...
April 11, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29600046/bronchoalveolar-lavage-fluid-microbiota-dysbiosis-in-infants-with-protracted-bacterial-bronchitis
#3
Yanmin Bao, Yinhu Li, Chuangzhao Qiu, Wenjian Wang, Zhenyu Yang, Lu Huang, Xin Feng, Yanhong Liu, Jing Li, Qian Zhou, Heping Wang, Dongfang Li, Hongmei Wang, Wenkui Dai, Yuejie Zheng
Background: Protracted bacterial bronchitis (PBB) is a chronic purulent bronchitis which could cause recurrent coughing and wheezing in infants. Based on previous reports, main pathogens which caused PBB were identified in the patients, but their impacts on lung microbiota dysbiosis remain unclear. Methods: In this study, bronchoalveolar lavage fluid (BALF) was collected from PBB infants and tracheomalacia (TM) infants younger than 3 years old under the instruction of Shenzhen Children's Hospital, and 12 samples were randomly selected for 16S rDNA analysis in each group...
January 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29515570/factors-affecting-the-immunity-to-respiratory-syncytial-virus-from-epigenetics-to-microbiome
#4
REVIEW
Wendy Fonseca, Nicholas W Lukacs, Catherine Ptaschinski
Respiratory syncytial virus (RSV) is a common pathogen that infects virtually all children by 2 years of age and is the leading cause of hospitalization of infants worldwide. While most children experience mild symptoms, some children progress to severe lower respiratory tract infection. Those children with severe disease have a much higher risk of developing childhood wheezing later in life. Many risk factors are known to result in exacerbated disease, including premature birth and early age of RSV infection, when the immune system is relatively immature...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29514655/respiratory-morbidity-through-the-first-decade-of-life-in-a-national-cohort-of-children-born-extremely-preterm
#5
Kaia Skromme, Maria Vollsæter, Knut Øymar, Trond Markestad, Thomas Halvorsen
BACKGROUND: Advances in perinatal care have markedly increased the prospects of survival for infants born extremely preterm (EP). The aim of this study was to investigate hospitalisation rates and respiratory morbidity from five to 11 years of age in a prospective national cohort of EP children born in the surfactant era. METHODS: This was a national prospective cohort study of all children born in Norway during 1999 and 2000 with gestational age (GA) < 28 weeks or birth weight < 1000 grams, and of individually matched term-born controls recruited for a regional subsample...
March 7, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29508714/infant-rhinitis-and-watery-eyes-predict-school-age-exercise-induced-wheeze-emergency-department-visits-and-respiratory-related-hospitalizations
#6
Khalil W Savary, Rachel L Miller, Emilio Arteaga-Solis, Lori Hoepner, Luis M Acosta, Frederica P Perera, Andrew G Rundle, Inge F Goldstein, Matthew S Perzanowski
BACKGROUND: Rhinitis and conjunctivitis are often linked to asthma development through an allergic pathway. However, runny nose and watery eyes can result from nonallergic mechanisms. These mechanisms can also underlie exercise-induced wheeze (EIW), which has been associated with urgent medical visits for asthma, independent of other indicators of asthma severity or control. OBJECTIVE: To test the hypothesis that rhinitis or watery eyes without cold symptoms (RWWC) in infancy predict development of EIW and urgent respiratory-related medical visits at school age, independent of seroatopy...
March 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29501252/pulmonary-function-in-former-very-low-birth-weight-preterm-infants-in-the-first-year-of-life
#7
Daniela de Melo Miranda Gonçalves, Gustavo Falbo Wandalsen, Ana Sílvia Scavacini, Fernanda Cordoba Lanza, Ana Lucia Goulart, Dirceu Solé, Amélia Miyashiro Nunes Dos Santos
BACKGROUND: Pulmonary function in former preterm infants may be compromised during childhood. OBJECTIVES: To assess pulmonary function in very-low-birth-weight preterm infants at 6-12 months of corrected age and analyze the factors associated with abnormal pulmonary function. METHODS: Cross-sectional study with preterm infants at 6-12 months of corrected age with birth weight <1500 g. Children with malformations or affected by neuromuscular and respiratory diseases were excluded...
March 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29500030/respiratory-syncytial-virus-prevention-and-asthma-in-healthy-preterm-infants-a-randomised-controlled-trial
#8
Nienke M Scheltema, Elisabeth E Nibbelke, Juliëtte Pouw, Maarten O Blanken, Maroeska M Rovers, Christiana A Naaktgeboren, Natalie I Mazur, Joanne G Wildenbeest, Cornelis K van der Ent, Louis J Bont
BACKGROUND: Respiratory syncytial virus (RSV) infection is associated with subsequent wheeze and asthma. We previously reported on the causal relationship between prevention of RSV infection during infancy and reduced frequency of subsequent wheeze using a double-blind, randomised, placebo-controlled trial (MAKI). We continued follow-up and analysed the effect of RSV prevention during infancy on asthma and lung function at age 6 years. METHODS: We studied 429 infants born at 32-35 weeks of gestation between 2008-10 who had randomly received either palivizumab for RSV immunoprophylaxis or placebo during the RSV season of their first year of life...
February 27, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29470837/past-present-and-future-approaches-to-the-prevention-and-treatment-of-respiratory-syncytial-virus-infection-in-children
#9
REVIEW
Eric A F Simões, Louis Bont, Paolo Manzoni, Brigitte Fauroux, Bosco Paes, Josep Figueras-Aloy, Paul A Checchia, Xavier Carbonell-Estrany
INTRODUCTION: The REGAL (RSV Evidence - A Geographical Archive of the Literature) series has provided a comprehensive review of the published evidence in the field of respiratory syncytial virus (RSV) in Western countries over the last 20 years. This seventh and final publication covers the past, present and future approaches to the prevention and treatment of RSV infection among infants and children. METHODS: A systematic review was undertaken of publications between January 1, 1995 and December 31, 2017 across PubMed, Embase and The Cochrane Library...
February 22, 2018: Infectious Diseases and Therapy
https://www.readbyqxmd.com/read/29457208/children-deserve-smoke-free-world
#10
REVIEW
R Remesh Kumar, P R Jayakumar, R Krishna Mohan
Tobacco smoke, active or passive exposure was the major cause of preventable morbidity and mortality in the world during twentieth century and will continue to be the same in the twenty-first century also if the current trends continue. Both active and passive smoking are having significance in relation to child health. Exposure starts antenatally from placenta to the fetus and later phases through passive exposure to experimental and regular smoking and ultimately addiction and habitual smoking. Evidences are in favour of causal relationship with intrauterine growth restriction, sudden infant death syndrome, decreased pulmonary function, increased risk for respiratory tract infection, otitis media, wheeze, asthma, neurobehavioral disorders, cleft palate and triggering pathogenesis of fetal and childhood onset of adult diseases, especially pulmonary and cardio vascular diseases...
February 19, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29389825/symptoms-signs-and-long-term-prognosis-of-vertically-transmitted-chlamydia-trachomatis-infections
#11
Minna Honkila, Marjo Renko, Tytti Pokka, Erika Wikström, Matti Uhari, Terhi Tapiainen
BACKGROUND: Although Chlamydia trachomatis infection is common in pregnant women, such infections are rarely encountered in infants. In order to clarify the recognition of C. trachomatis infections in infants, we analyzed symptoms and signs of perinatally acquired chlamydial infection, together with its long-term prognosis in a large population-based patient series. METHODS: A search through two national health registries covering 1996-2011, a cohort of 933 823 births, yielded 124 children with a microbiologically confirmed C...
January 31, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29385277/prenatal-phthalate-exposure-was-associated-with-croup-in-swedish-infants
#12
Huan Shu, Sverre Wikstrom, Bo A G Jönsson, Christian H Lindh, Åke Svensson, Eewa Nånberg, Carl-Gustaf Bornehag
AIM: This study examined whether prenatal phthalate exposure was associated with lower or upper airway inflammation in infants. METHODS: From 2007 to 2010, we used liquid chromatography-tandem mass spectrometry, adjusted for creatinine, to analyse 14 phthalate metabolites and one phthalate replacement in the urine of 1062 Swedish mothers at a median of 10 weeks of pregnancy. This was used to determine any associations between prenatal phthalate exposure and croup, wheezing or otitis in their offspring until 12 months of age, using logistic regression, adjusted for potential confounders...
January 31, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29382526/-recurrent-wheezing-prevalence-and-associated-factors-in-infants-from-buenos-aires-city-argentina
#13
Gabriela Aída Szulman, Héctor Freilij, Ilse Behrends, Ángela Gentile, Javier Mallol
BACKGROUND: The episodes of bronchial obstruction at early age constitute a frequent problem in Pediatrics. The aim of this study was to evaluate the prevalence of recurrent wheezing in infants in Buenos Aires City, as well as to identify any associated factors. METHODS: Cross-sectional study performed from 2011 to 2012 in the Children Hospital Ricardo Gutiérrez, Buenos Aires City, as part of the International Study of Wheezing in Infants. A validated questionnaire was applied to parents of infants aged between 12 and 15 months...
November 2017: Boletín Médico del Hospital Infantil de México
https://www.readbyqxmd.com/read/29380391/rsv-hrv-co-infection-is-a-risk-factor-for-recurrent-bronchial-obstruction-and-early-sensitization-3-years-after-bronchiolitis
#14
Flore Amat, Chloé Plantard, Aurélien Mulliez, Isabelle Petit, Emmanuelle Rochette, Matthieu Verdan, Cécile Henquell, Guillaume Labbé, Marie Christine Heraud, Bertrand Evrard, André Labbé
To assess risk factors of recurrent bronchial obstruction and allergic sensitization 3 years after an episode of acute bronchiolitis, whether after ambulatory care treatment or hospitalization. A monocentric prospective longitudinal study including infants aged under 1 year with acute bronchiolitis was performed, with clinical (severity score), biological (serum Krebs von den Lungen 6 antigen), and viral (14 virus by naso-pharyngeal suction detection) assessments. Follow-up included a quaterly telephone interview, and a final clinical examination at 3 years...
January 30, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29359411/parainfluenza-virus-type-3-outbreak-in-a-neonatal-intensive-care-unit
#15
Hajime Maeda, Kentaro Haneda, Yoshinobu Honda
Parainfluenza virus (PIV) is a respiratory pathogen in young children and is second only to the respiratory syncytial virus (RSV) as a cause of lower respiratory tract infection. PIV type 3 (PIV3) is the most severe. Herein we describe an outbreak of PIV3 in three infants in a neonatal intensive care unit. They were diagnosed on virus culture from pharyngeal swabs. We prevented the spread of the virus using standard infection control procedures and isolation of the symptomatic infants. One infant had severe chronic lung disease and was complicated with recurrent wheezing for a long time...
November 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29273135/complex-relationships-between-vitamin-d-and-allergic-sensitization-among-puerto-rican-2-year-old-children
#16
Srimathi Kannan, Matthew S Perzanowski, Harish B Ganguri, Dolores Acevedo-Garcia, Luis M Acosta, Molly Spatcher, Adnan Divjan, Ginger L Chew
BACKGROUND: In the United States, Puerto Ricans have a higher prevalence of asthma than other Latino ethnicities. Low vitamin D levels for children living in northern climates could be a factor. OBJECTIVE: To assess serum 25-hydroxyvitamin D [25(OH)D] distributions (a marker of vitamin D) and associations among vitamin D, allergic sensitization, early wheeze, and home/demographic factors. METHODS: Puerto Rican infants born in New York City, with a maternal history of atopy, were enrolled in a birth cohort...
January 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29246125/low-birth-weight-contributed-to-increased-serum-il-6-levels-in-infantile-respiratory-syncytial-virus-infection
#17
Yuan-Jian Sheng, Shan-Shan Xu, Xue-Jing Li, Jin-Ling Liu, Xi-Ling Wu, Xue-Feng Xu
BACKGROUND: To evaluate the role of serum cytokines in the pathogenesis of respiratory syncytial virus (RSV) infection in infants with low birth weight (LBW). METHODS: A prospective observational study was performed, and hospitalized children with lower respiratory tract infection (LRTI) were recruited. Three hundred fifty-eight patients < 1 year met the inclusion criteria: 116 patients had only RSV infection (RSV group); 242 patients had no RSV or other specific pathogen (non-RSV group)...
December 16, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/29241587/associations-between-infant-fungal-and-bacterial-dysbiosis-and-childhood-atopic-wheeze-in-a-nonindustrialized-setting
#18
Marie-Claire Arrieta, Andrea Arévalo, Leah Stiemsma, Pedro Dimitriu, Martha E Chico, Sofia Loor, Maritza Vaca, Rozlyn C T Boutin, Evan Morien, Mingliang Jin, Stuart E Turvey, Jens Walter, Laura Wegener Parfrey, Philip J Cooper, Brett Finlay
BACKGROUND: Asthma is the most prevalent chronic disease of childhood. Recently, we identified a critical window early in the life of both mice and Canadian infants during which gut microbial changes (dysbiosis) affect asthma development. Given geographic differences in human gut microbiota worldwide, we studied the effects of gut microbial dysbiosis on atopic wheeze in a population living in a distinct developing world environment. OBJECTIVE: We sought to determine whether microbial alterations in early infancy are associated with the development of atopic wheeze in a nonindustrialized setting...
November 30, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29230219/functional-impairment-of-mononuclear-phagocyte-system-by-the-human-respiratory-syncytial-virus
#19
REVIEW
Karen Bohmwald, Janyra A Espinoza, Raúl A Pulgar, Evelyn L Jara, Alexis M Kalergis
The mononuclear phagocyte system (MPS) comprises of monocytes, macrophages (MΦ), and dendritic cells (DCs). MPS is part of the first line of immune defense against a wide range of pathogens, including viruses, such as the human respiratory syncytial virus (hRSV). The hRSV is an enveloped virus that belongs to the Pneumoviridae family, Orthopneumovirus genus. This virus is the main etiological agent causing severe acute lower respiratory tract infection, especially in infants, children and the elderly. Human RSV can cause bronchiolitis and pneumonia and it has also been implicated in the development of recurrent wheezing and asthma...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29210195/hair-nicotine-at-15-months-old-tobacco-exposure-and-wheeze-or-asthma-from-15-months-to-6-years-old
#20
Philip K Pattemore, Karen M Silvers, Chris M Frampton, Kristin Wickens, Tristram Ingham, David Fishwick, Julian Crane, G Ian Town, Michael J Epton
OBJECTIVE: To investigate the relationship between hair nicotine levels at 15 months of age and prior parent-reported smoking exposure, and the risk of wheezing and current asthma from 15 months to 6 years of age. STUDY DESIGN: We measured hair nicotine levels at 15 months of age in 376 of 535 infants enrolled in a prospective birth cohort in Christchurch, New Zealand. We obtained detailed information from parents about smoking exposure during pregnancy and in the home at 3 and 15 months of age...
December 6, 2017: Pediatric Pulmonology
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