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https://www.readbyqxmd.com/read/28743043/neurotrophy-and-immunomodulation-of-induced-neural-stem-cell-grafts-in-a-mouse-model-of-closed-head-injury
#1
Mou Gao, Hui Yao, Qin Dong, Yan Zhang, Yang Yang, Yihua Zhang, Zhijun Yang, Minhui Xu, Ruxiang Xu
Closed head injury (CHI) usually results in severe and permanent neurological impairments, which are caused by several intertwined phenomena, such as cerebral edema, blood-brain barrier (BBB) disruption, neuronal loss, astroglial scarring and inflammation. We previously reported that induced neural stem cells (iNSCs), similar to neural stem cells (NSCs), can accelerate neurological recovery in vivo and produce neurotrophic factors in vitro. However, the effects of iNSC neurotrophy following CHI were not determined...
July 18, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/28742608/epidemiology-of-injuries-in-women-s-lacrosse-implications-for-sport-level-and-sex-specific-injury-prevention-strategies
#2
Kim D Barber Foss, Ed Le Cara, Teri McCambridge, Richard Y Hinton, Adam Kushner, Gregory D Myer
OBJECTIVE: By the end of 2013, the United States had an estimated 278 000 female lacrosse players, with half of those participating at the youth level. The effects of the sport's rapid growth on injury rates have yet to be determined. The purpose of this clinical review is to synthesize the available published data on injuries that have occurred in the sport of women's lacrosse. Of particular interest was the risk of injury based on the level of play and position. DATA SOURCES: A comprehensive literature search was performed in PubMed, High Wire Press, SPORTDiscus, Google Scholar, and Ovid using the keywords "Lacrosse Injuries," "Epidemiology Lacrosse Injuries," "Lacrosse Injury," "Lacrosse," and "Injury...
July 21, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28741437/traumatic-brain-injury-in-a-community-based-cohort-of-homeless-and-vulnerably-housed-individuals
#3
Toby Schmitt, Allen Thornton, Iris Rawtaer, Alasdair Barr, Kristina Gicas, Donna Lang, Talia Vertinsky, Alexander Rauscher, Ric Procyshyn, Tari Buchanan, Alex Cheng, Sarah Mackay, Olga Leonova, Verena Langheimer, Thalia Field, Manraj K S Heran, Fidel Vila-Rodriguez, Tiffany-Anne O'Connor, William MacEwan, William Honer, William Panenka
We characterized traumatic brain injury (TBI) and studied its associations with mental and physical health in a community cohort of homeless and vulnerably-housed individuals. METHODS: Detailed mental and physical health structured interviews, neuropsychological testing, and multimodal MRI were performed on 283 participants. Two traumatic brain injury (TBI) participant groups were defined for primary analyses: those with a self-reported history of TBI and those with MRI evidence of TBI...
July 25, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28741220/independent-impact-of-plasma-homocysteine-levels-on-neurological-outcome-following-head-injury
#4
Sivashanmugam Dhandapani, Ankur Bajaj, Chandrasekar Gendle, Inderjeet Saini, Irwanjeet Kaur, Isha Chaudhary, Jasandeep, Jaspinder Kaur, Geetanjali Kalyan, Manju Dhandapani, Sunil K Gupta
Homocysteine (tHcy) has been hardly studied among patients with head injury. This study was to evaluate whether there is any independent impact of tHcy levels on neurological outcome following head injury in a multivariate model. Patients admitted within 24 h of injury were included in the study, along with 20 age- and gender-matched controls. Plasma levels of tHcy were measured at admission using direct immunoassay. All the variables were analyzed with respect to tHcy levels and outcome according to Glasgow Outcome Score (GOS) at 3 months...
July 24, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28740997/guidelines-for-bystander-first-aid-2016
#5
Jen Heng Pek
Cardiac life support is a form of first aid for cardiac emergencies. However, research and evidence in this field is lacking compared with other forms of first aid. Having identified the common emergencies that are encountered in the hospital, based on the available evidence, we have put together what could be an evidence-based approach to the first aid management of some of these common emergencies, viz. breathlessness, chest pain, allergies, stroke, heat injury, poisoning, unconsciousness, seizures, and trauma situations such as bleeding, wounds, contusions, head injury, burns and fractures...
July 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28739290/implementation-of-the-canadian-ct-head-rule-and-its-association-with-use-of-computed-tomography-among-patients-with-head-injury
#6
Adam L Sharp, Brian Z Huang, Tania Tang, Ernest Shen, Edward R Melnick, Arjun K Venkatesh, Michael H Kanter, Michael K Gould
STUDY OBJECTIVE: Approximately 1 in 3 computed tomography (CT) scans performed for head injury may be avoidable. We evaluate the association of implementation of the Canadian CT Head Rule on head CT imaging in community emergency departments (EDs). METHODS: We conducted an interrupted time-series analysis of encounters from January 2014 to December 2015 in 13 Southern California EDs. Adult health plan members with a trauma diagnosis and Glasgow Coma Scale score at ED triage were included...
July 21, 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28738538/diosmin-improved-cognitive-deficit-and-amplified-brain-electrical-activity-in-the-rat-model-of-traumatic-brain-injury
#7
Mohammad Ali Mirshekar, Hamed Fanaei, Fereshteh Keikhaei, Fatemeh Sargolzaee Javan
OBJECTIVE: Traumatic brain injury (TBI) is one of the main causes of intellectual and cognitive disabilities in humans. Clinically, it is essential to limit the progress of cognitive impairment after TBI. It is reported that diosmin has a neuroprotective effect that can limit the progress of the impairment. The aim of this study was to evaluate the effects of diosmin on neurological score, memory, tumor necrosis factor-α (TNF-α) level and long-term potentiation in hippocampal dentate gyrus after the injury...
July 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28738420/variation-in-the-three-dimensional-histomorphometry-of-the-normal-human-optic-nerve-head-with-age-and-race-lamina-cribrosa-and-peripapillary-scleral-thickness-and-position
#8
Christopher A Girkin, Massimo A Fazio, Hongli Yang, Juan Reynaud, Claude F Burgoyne, Brandon Smith, Lan Wang, J Crawford Downs
Purpose: This study quantified the thickness and depth of the lamina cribrosa (LC) and peripapillary scleral thickness in high-resolution three-dimensional (3D) fluorescent reconstructions of the optic nerve head (ONH) in eyes from donors of African (AD) and European descent (ED). Methods: A total of 64 eyes (45 ED, 19 AD) from 51 normal donors were obtained within 6 hours of death and fixed at 10 mm Hg of pressure. The optic nerve head was trephined from the globe and digitally reconstructed at 1...
July 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28738168/role-of-age-and-injury-mechanism-in-cervical-spine-injury-tolerance-under-head-contact-loading
#9
Narayan Yoganandan, Sajal Chirvi, Liming Voo, Frank A Pintar, Anjishnu Banerjee
OBJECTIVE: To determine the influence of age on cervical spine tolerance to injury from head contact loading using survival analysis. METHODS: This study analyzed data from previously conducted experiments using Post Mortem Human Subject specimens (PMHS). Group A tests used the upright intact head-cervical column experimental model. The inferior end of the specimen was fixed, head was balanced by a mechanical system, and natural lordosis was removed. Specimens were placed on a testing device via a load cell...
July 24, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28738161/belted-driver-fatalities-time-of-death-and-risk-by-injury-severity
#10
David C Viano, Chantal S Parenteau
PURPOSE: This study is a descriptive study of the fatality risk by injury severity and time of death for lap-shoulder belted drivers without ejection in modern vehicles. It also determined the body region for severe injuries experienced by the belted drivers using the most recent federal crash data. METHODS: 1997-2015 NASS-CDS data was evaluated for fatally-injured lap-shoulder belted drivers without ejection in light vehicles of 1997+ model year (MY). The severity of injuries sustained by the belted drivers was assessed by MAIS and individual injuries by AIS and body region...
July 24, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28737727/patterns-associated-with-adult-mandibular-fractures-in-southern-taiwan-a-cross-sectional-retrospective-study
#11
Ko-Chien Lin, Shu-Hui Peng, Pao-Jen Kuo, Yi-Chun Chen, Cheng-Shyuan Rau, Ching-Hua Hsieh
Purpose: This study aimed to determine the patterns associated with adult mandibular fractures from a Level-I trauma center in southern Taiwan. Methods: The data of adult trauma patients admitted between 1 January 2009 and 31 December 2014 were retrieved from the Trauma Registry System and retrospectively reviewed. Fracture site and cause of injury were categorized into groups for comparison, and corresponding odds ratios (ORs) and 95% confidence intervals (CIs) were obtained by multivariate logistic regression...
July 24, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28737561/a-cadaver-study-to-assess-the-feasibility-of-a-cross-nerve-transfer-of-the-infraorbital-nerve-for-patients-with-peripheral-infraorbital-nerve-injury
#12
Tomoyuki Yano, Keiichi Akita, Kumiko Yamaguchi, Masayuki Sawaizumi
BACKGROUND: Patients with facial fracture or head and neck surgery sometimes suffer from infraorbital nerve injury. This injury results in severe hemilateral numbness in the midfacial area. The infraorbital nerve ends with two major branches; the infra nasal branch (INB) and superior labial branch (SLB). In this study, we assessed the feasibility of cross-nerve transfer of the INB and SLB based on a cadaver study. METHODS: The INB/SLB from a total 20 sides of 10 cadavers (2 men and 8 women; average age, 79...
July 22, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28736795/identifying-characteristics-and-outcomes-that-are-associated-with-fall-related-fatalities-multi-year-retrospective-summary-of-fall-deaths-in-older-adults-from-2005-2012
#13
Sara M Deprey, Lynda Biedrzycki, Kristine Klenz
BACKGROUND: Fall-related deaths continue to be the leading cause of accidental deaths in the older adult (65+ year) population. However, many fall-related fatalities are unspecified and little is known about the fall characteristics and personal demographics at the time of the fall. Therefore, this report describes the characteristics, circumstances and injuries of falls that resulted in older adult deaths in one U.S. County and explores the variables associated with fatal injuries from falls...
December 2017: Injury Epidemiology
https://www.readbyqxmd.com/read/28736357/incidence-demographics-and-outcome-of-traumatic-brain-injury-in-the-middle-east-a-systematic-review
#14
REVIEW
Ayman El-Menyar, Ahammed Mekkodathil, Hassan Al-Thani, Rafael Consunji, Rifat Latifi
BACKGROUND: Traumatic brain injury (TBI) is a serious global public health challenge. We aimed to assess the pattern of TBI in the Middle East, as reported in the last decade. METHODS: Literature searches were conducted on PubMed, MEDLINE and Google scholar electronic databases. The search-terms used in different combinations were epidemiology, incidence, case fatality, mortality, intracranial injury, brain injury, head injury and the country names. Additional searches were conducted using reference lists of studies and review articles for selection of relevant articles...
July 20, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28736353/sport-related-structural-brain-injury-three-cases-of-subdural-hemorrhage-in-american-high-school-football
#15
Aaron M Yengo-Kahn, Ryan M Gardner, Andrew W Kuhn, Gary S Solomon, Christopher M Bonfield, Scott L Zuckerman
BACKGROUND: The risk of sport-related concussion (SRC) has emerged as a major public health concern. In rare instances, sport-related head injuries can be even more severe, such as subdural hemorrhage, epidural hemorrhage, or malignant cerebral edema. Unlike SRCs, sport-related structural brain injury (SRSBI) is rare, may require neurosurgical intervention, and can lead to permanent neurologic deficit or death. Data characterizing SRSBI is limited and many have recognized the need to better understand these catastrophic brain injuries...
July 20, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28735839/epidemiology-of-proximal-humeral-fractures-a-detailed-survey-of-711-patients-in-a-metropolitan-area
#16
Daniele Passaretti, Vittorio Candela, Pasquale Sessa, Stefano Gumina
BACKGROUND: Literature lacks data concerning several epidemiologic aspects of proximal humeral fractures (PHFs). METHODS: This retrospective study included 711 consecutive patients (209 men, 502 women) who sustained a PHF in the last 3 years. Participants were divided into 2 groups, adults and children. Data regarding age, sex, date, and fracture side were collected. According to the mechanism of injury, we arbitrarily distinguished 7 subgroups. PHFs were classified according to the head-greater-lesser-shaft (HGLS)-Hertel classification and to the Salter-Harris classification using x-ray and computed tomography imaging...
July 20, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28734719/coronoid-reconstruction-using-osteochondral-grafts-a-biomechanical-study
#17
Enrico Bellato, Youngbok Kim, James S Fitzsimmons, Lawrence J Berglund, Alexander W Hooke, Daniel R Bachman, Shawn W O'Driscoll
HYPOTHESIS: The purposes of this study were to test the hypothesis that coronoid deficiency in the setting of posteromedial rotatory instability (PMRI) must be reconstructed to restore articular contact pressures to normal and to compare 3 different osteochondral grafts for this purpose. METHODS: After creation of a anteromedial fracture, six cadaveric elbows were tested under gravity varus stress using a custom-made machine designed to simulate muscle loads and to passively flex the elbow...
July 19, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28734536/evaluation-of-functional-outcome-after-nonsurgical-management-of-terrible-triad-injuries-of-the-elbow
#18
Farid Najd Mazhar, Davod Jafari, Alireza Mirzaei
BACKGROUND: Terrible triad (TT) is one of the severe injuries of the elbow that generally requires surgery. Nonsurgical treatment has recently been applied in selected cases of TT injury. Evaluation of the results of this treatment was the main aim of this study. METHODS: In a prospective cohort study, 10 patients with a mean follow-up of 30.6 months were evaluated. The inclusion criteria included a congruent joint after closed reduction, no indication for surgery of the coronoid and radial head fractures, no block in supination and pronation up to 60°, no intra-articular fragments, and a free and stable joint with ulnohumeral extension up to a minimum of 45°...
August 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28732255/can-head-trauma-trigger-adult-onset-rasmussen-s-encephalitis
#19
Derrick Soh, Dennis J Cordato, Andrew F Bleasel, Peter Brimage, Roy G Beran
Rasmussen's encephalitis (RE) is a rare unilateral inflammatory brain disorder that causes progressive neurocognitive deterioration and refractory epilepsy including epilepsia partialis continua (EPC). We describe a patient with a unique presentation, where right upper limb EPC due to RE began within 2weeks of a concussive left frontal head injury, in a 36-year-old female without other identifiable etiology, no prior neurological deficit nor suggestion of intracranial pathology or infection, and no preceding seizures...
July 18, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28730395/dynamic-hip-screw-and-fibular-strut-graft-for-fixation-of-fresh-femoral-neck-fracture-with-posterior-comminution
#20
Adham Elgeidi, Abed El Negery, M Serry Abdellatif, Nabil El Moghazy
INTRODUCTION: Posterior comminution of the femoral neck fracture is a major cause of delayed and non-union owing to the loss of the buttressing effect against the posterior rotation. When a femoral neck fracture with posterior comminution is anatomically reduced, only the anterior portions of the femoral neck fracture surfaces are brought into contact leaving a posterior defect. The purpose of this study was to evaluate the use of fibular strut grafting and dynamic hip screw (DHS) for fresh femoral neck fractures with posterior comminution in young patient less than 50 years...
July 20, 2017: Archives of Orthopaedic and Trauma Surgery
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