keyword
https://read.qxmd.com/read/38547511/operating-properties-of-disease-activity-indices-in-pediatric-inflammatory-bowel-disease-a-systematic-review
#1
JOURNAL ARTICLE
Ruben J Colman, Virginia Solitano, John K MacDonald, Christopher Ma, Anne M Griffiths, Vipul Jairath, Eileen Crowley
BACKGROUND: Accurate, reliable, and responsive disease activity indices are important to streamline drug approval and treatment modalities for pediatric inflammatory bowel disease (pIBD). We aimed to identify all scoring indices used in pIBD randomized controlled trials (RCTs) and to evaluate their operating properties. METHODS: MEDLINE, EMBASE, and CENTRAL were searched on December 6, 2022, to identify studies evaluating clinical, endoscopic, imaging, or patient-reported outcome measures (PROMs) in pIBD including Crohn's disease (CD) and ulcerative colitis (UC)...
March 28, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38547319/impact-of-the-uk-soft-drinks-industry-levy-on-health-and-health-inequalities-in-children-and-adolescents-in-england-an-interrupted-time-series-analysis-and-population-health-modelling-study
#2
JOURNAL ARTICLE
Linda J Cobiac, Nina T Rogers, Jean Adams, Steven Cummins, Richard Smith, Oliver Mytton, Martin White, Peter Scarborough
BACKGROUND: The soft drinks industry levy (SDIL) in the United Kingdom has led to a significant reduction in household purchasing of sugar in drinks. In this study, we examined the potential medium- and long-term implications for health and health inequalities among children and adolescents in England. METHODS AND FINDINGS: We conducted a controlled interrupted time series analysis to measure the effects of the SDIL on the amount of sugar per household per week from soft drinks purchased, 19 months post implementation and by index of multiple deprivation (IMD) quintile in England...
March 28, 2024: PLoS Medicine
https://read.qxmd.com/read/38546591/a-randomized-controlled-trial-examining-the-effect-of-camp-hope-tennessee-on-youth-functioning-results-from-a-pilot-study
#3
JOURNAL ARTICLE
Amanda J Hasselle, Kathryn H Howell, Anissa Garza, Kari N Thomsen, Hannah C Gilliam
OBJECTIVE: Family violence can negatively affect youth's psychosocial functioning. Strengths-based interventions may enhance positive youth functioning among youth experiencing adversity, but little is known about the effectiveness of camp-based interventions for youth exposed to family violence. The current study examined the effectiveness of Camp HOPE Tennessee in promoting multidimensional well-being and school engagement among youth exposed to family violence. METHOD: This pilot study employed a nonmasked, parallel randomized controlled design...
March 28, 2024: Psychological Trauma: Theory, Research, Practice and Policy
https://read.qxmd.com/read/38546160/developmental-and-behavioral-phenotypes-of-pediatric-patients-with-pten-hamartoma-tumor-syndrome
#4
JOURNAL ARTICLE
Suzanne P MacFarland, Melani Duvall, Raissa Tchetcho Kemajou, Sarah E Baldino, Kristin Zelley, Chelsea Black, Allison Thomas, Nina H Thomas, Melanie Ruffner, Yimei Li, Judith S Miller, Garrett M Brodeur, Emily Shabason
Our study characterized the neurodevelopmental spectrum of individuals with PTEN Hamartoma Tumor Syndrome (PHTS), a syndrome that predisposes to both neurodevelopmental phenotypes and cancer risk. We aim to better understand life-impacting neurodevelopmental features of PHTS. Our study recruited 20 children/adolescents with PHTS, who were then administered assessments for autism spectrum disorder (ASD) and other neurocognitive measures, including assessment of IQ, executive and adaptive functioning, and health-related quality of life...
March 28, 2024: American Journal of Medical Genetics. Part A
https://read.qxmd.com/read/38545728/predictive-factors-of-renal-graft-failure-in-tunisian-children-and-young-adults-a-retrospective-study
#5
JOURNAL ARTICLE
Abir Boussetta, Manel Jellouli, Tahar Gargah, Meriem Hajji, Hafedh Hedri, Ezzeddine Abderrahim
INTRODUCTION: Pediatric end-stage renal disease is a rare but severe condition that causes numerous complications and impairs the quality of life of children. Kidney transplantation is the therapy of choice in pediatric end-stage renal disease. AIM: Our study aimed to identify the predictive factors of renal graft failure after kidney transplantation in Tunisian children and young adults. METHODS: We conducted a retrospective bicentric study of children and young adults (age≤20 years) who had undergone renal transplantation between 1989 and 2019 in Tunisia...
January 5, 2024: La Tunisie Médicale
https://read.qxmd.com/read/38545273/evaluating-the-impact-of-lactase-supplementation-on-infant-colic-study-protocol-for-a-systematic-review-of-randomized-controlled-trials
#6
REVIEW
Anna Kozłowska-Jalowska, Agata Stróżyk, Andrea Horvath, Hania Szajewska
Infant colic is a common functional gastrointestinal disorder that affects infants during their first months of life. The etiology of this condition remains unclear. However, some studies suggest lactase deficiency may be a contributing factor. Currently, the evidence on dietary treatment and lactase supplementation for management of infant colic is limited. We aim to systematically review evidence on the efficacy and safety of using a lactase supplementation for managing infant colic. The Cochrane Central Register of Controlled Trials (CENTRAL, the Cochrane Library), MEDLINE, and EMBASE will be searched to identify randomized controlled trials comparing oral lactase supplementation with placebo or no intervention in infants aged less than 6-month-old with infant colic using any recognized definition...
February 2024: JPGN reports
https://read.qxmd.com/read/38545272/gastric-emptying-and-myoelectrical-activity-testing-in-children-with-esophageal-atresia-a-pilot-study
#7
JOURNAL ARTICLE
Carlijn Mussies, Gilles Duvoisin, Angela Le, Selin Birro, Sarah Hulbert, Taher Omari, Marc A Benninga, Michiel P van Wijk, Usha Krishnan
OBJECTIVES: Abnormalities of gastric function in children with esophageal atresia (EA) could potentially contribute to gastrointestinal symptoms and reduced quality of life (QOL). Therefore, we aimed to determine the feasibility and clinical usefulness of gastric function testing in children with EA. METHODS: The validated PedsQL Gastrointestinal Symptoms Questionnaire (PedsQL-GI) was completed to assess gastrointestinal symptoms and symptom-related QOL. Gastric emptying and gastric myoelectrical activity were studied using 13 C-gastric emptying octanoic acid breath test (13 C-GEBT) and surface electrogastrography (EGG)...
February 2024: JPGN reports
https://read.qxmd.com/read/38545264/duodenal-obstruction-a-rare-complication-of-severe-acute-pancreatitis-in-children
#8
Olivier Leclercq, Laurie Lecomte, Xavier Stephenne, Isabelle Scheers
Duodenal obstruction (DO) is an uncommon complication of pancreatitis. It has been described in groove and severe acute and chronic pancreatitis in adults but, to the best of our knowledge, it has not yet been reported in pediatric acute pancreatitis. Current guidelines comment on management of several early and late-onset complications, but DO is not mentioned. We describe two patients with acute necrotizing pancreatitis who presented with several complications including walled-off necrosis and DO. In adults, DO is generally managed with adapted nutrition but may require surgical bypass, such as gastroenterostomy...
February 2024: JPGN reports
https://read.qxmd.com/read/38544965/clinical-and-genetic-analysis-of-patients-with-tk2-deficiency
#9
JOURNAL ARTICLE
Francisco Ceballos, Pablo Serrano-Lorenzo, Laura Bermejo-Guerrero, Alberto Blázquez, Juan F Quesada-Espinosa, Jorge Amigo, Pablo Minguez, Carmen Ayuso, Elena García-Arumí, Nuria Muelas, Teresa Jaijo, Andres Nascimento, Beatriz Galán-Rodriguez, Carmen Paradas, Joaquín Arenas, Angel Carracedo, Ramon Martí, Miguel A Martín, Cristina Domínguez-González
OBJECTIVES: Thymidine kinase 2 deficiency (TK2d) is a rare autosomal recessive disorder that stems from a perturbation of the mitochondrial DNA maintenance. Nucleoside treatment has recently shown promise as a disease-modifying therapy. TK2d was initially associated with rapidly progressive fatal myopathy in children featuring mitochondrial DNA depletion. Subsequently, less severe variants of the disease were described, with onset of symptoms during adolescence or adulthood and associated with the presence of multiple mtDNA deletions...
April 2024: Neurology. Genetics
https://read.qxmd.com/read/38544851/gender-differences-in-geriatric-depressive-symptoms-in-urban-china-the-role-of-adl-and-sensory-and-communication-abilities
#10
JOURNAL ARTICLE
Ling Guo, Mingwang Fang, Lingying Wang, Li Liu, Chunxia He, Xiumei Zhou, Yi Lu, Xiuying Hu
OBJECTIVES: ADL and Sensory and Communication Abilities are important indicators of the quality of life of the elderly which are significant determinants of health, particularly in developing countries. The present cross-sectional study investigated effect of ADL and Sensory and Communication Abilities on depressive symptoms, as well as the the role of gender in these effects. DESIGN: This is a cross-sectional study. SETTING: A nationally representative cross-sectional survey among the Chinese population aged 60 years and over...
2024: Frontiers in Psychiatry
https://read.qxmd.com/read/38542757/body-composition-and-anthropometric-measurements-in-children-and-adolescents-with-autism-spectrum-disorder-a-case-control-study-in-lebanon
#11
JOURNAL ARTICLE
Melissa Rouphael, Yonna Sacre, Tania Bitar, Christian R Andres, Walid Hleihel
The occurrence of overweight and obesity among individuals with Autism Spectrum Disorder (ASD) has become a worldwide epidemic. However, there is limited research on this topic in the Lebanese population. Therefore, this study aimed to assess the differences in anthropometric measurements and body composition variables among Lebanese children, pre-adolescents, and adolescents diagnosed with ASD in contrast to typically developing peers across various developmental stages. Additionally, it aimed to investigate the prevalence of overweight and obesity within this population...
March 15, 2024: Nutrients
https://read.qxmd.com/read/38541925/the-burden-of-pediatric-atopic-dermatitis-quality-of-life-of-patients-and-their-families
#12
JOURNAL ARTICLE
Inga Kisieliene, Antanas Mainelis, Odilija Rudzeviciene, Matilda Bylaite-Bucinskiene, Andreas Wollenberg
(1) Background: Atopic dermatitis (AD) is one of the most common inflammatory skin conditions, thus having a significant impact on the quality of life (QoL) of patients and their families. We performed a survey to gather more data to help describe the burden of AD in Lithuania and to help expand the treatment plan to this important aspect of the disease. (2) Methods: A cross-sectional study was conducted involving healthy and AD pediatric patients. The assessment instruments used were the Patient-Oriented Eczema Measure (POEM), QoL, and original questionnaires (the original questionnaire was designed by the authors to determine the demographics, medical history, and treatment methods of the respondents)...
March 15, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541791/what-factors-predict-adaptive-functioning-in-preschool-children-with-autism-spectrum-disorder-a-longitudinal-study
#13
JOURNAL ARTICLE
Laura Casula, Maria Grazia Logrieco, Giulio D'Urso, Silvia Guerrera, Emanuela Petrolo, Ilaria Nicolì, Vittoria Celentano, Giusi Antonia Toto, Stefano Vicari, Mirco Fasolo, Giovanni Valeri
Adaptive functioning constitutes a fundamental aspect of the phenotype associated with autism spectrum disorder (ASD) in preschool-aged children, exerting a significant influence on both the child and the family's overall quality of life. The aim of this study was to investigate the predictors of the adaptive functioning domains in preschool-age children with ASD at two time points, providing a snapshot of this fundamental developmental step. Methods: Ninety-five children with ASD ( M = 3.89, SD = 1.13) were included in the study and longitudinal data (the mean length of the longitudinal data collection was 1 year) on ASD features such as social communication and social interaction, repetitive and restricted behavior, cognitive level, and adaptive functioning were collected...
March 9, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541676/exploring-the-potential-of-il-4-and-il-13-plasma-levels-as-biomarkers-in-atopic-dermatitis
#14
JOURNAL ARTICLE
George G Mitroi, Elena Leocadia Pleșea, George F Mitroi, Mihaela Roxana Mitroi, Carmen Daniela Neagoe, Simona Laura Ianoși
Atopic dermatitis (AD) is a persistent inflammatory skin condition that impacts individuals of various age groups, including both children and adults. Its pathophysiology involves allergens penetrating a disrupted epidermal barrier, triggering the dermal cells to produce pro-inflammatory cytokines and eliciting a T-cell-mediated immune response. Notably, interleukins (ILs), particularly interleukin 4 (IL-4) and interleukin 13 (IL-13), play a key role in AD pathogenesis. Therapies directed at inflammatory mechanisms, including Dupilumab, have demonstrated notable effectiveness in enhancing skin lesions, alleviating subjective symptoms, and improving the overall quality of life for individuals with AD...
March 7, 2024: Life
https://read.qxmd.com/read/38541305/oral-health-related-quality-of-life-in-italian-children-and-adolescents-living-with-bone-dysplasia-a-cross-sectional-study
#15
JOURNAL ARTICLE
Patrizia Defabianis, Rossella Ninivaggi, Daniele Tessaris, Norma Bocca, Federica Romano
Bone dysplasia (BD) refers to a group of rare disorders characterized by skeletal and dental anomalies which may negatively influence oral health-related quality of life (OHRQoL). The aim of this cross-sectional study was to assess the impact of BD on OHRQoL in Italian children and adolescents and to assess whether gender and age influence their OHRQoL. A total of 40 patients with BD and 40 age- and gender-matched controls (aged 8-14 years) were asked to complete the Oral Health Impact Profile-14 (OHIP-14), Child Oral Health Impact Profile (COHIP), and the short form of the Child Perceptions Questionnaire (SF-CPQ)...
March 6, 2024: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/38541251/charting-the-future-of-oral-health-a-bibliometric-exploration-of-quality-of-life-research-in-dentistry
#16
JOURNAL ARTICLE
Agatha Ravi Vidiasratri, Lisdrianto Hanindriyo, Caroline Manuela Hartanto
In recent decades, the focus of health research has shifted to the impact of disease or impairment on how people proceed, behave, and experience quality of life. People's lives are affected by oral diseases in various ways. Oral health-related quality of life (OHRQoL) is inextricably linked to general health and well-being, and it has far-reaching consequences for clinical practice and dentistry research. Particularly in Indonesia, increasing attention to OHRQoL is related to several concerning oral conditions, such as the extremely high number of cases of tooth decay and inflammation of dental supportive tissue that inexplicably lowers the population's OHRQoL...
February 22, 2024: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/38541183/sports-activities-in-children-with-cerebral-palsy-a-narrative-review
#17
REVIEW
Domenico M Romeo, Giulia D'Amario, Giulia Brunozzi, Valentina Napoli, Marianna Villa, Chiara Arpaia, Chiara Velli, Francesca Sini, Claudia Brogna
Physical exercise is known to have beneficial effects on psychosocial well-being and cognitive performance. Children with cerebral palsy (CP) showed lower levels of physical activity (PA) than healthy children; this fact, in addition to the basic clinical condition, increased the sedentary habit with a psychological impact and motor impairment of these children. Furthermore, children and adolescents with CP are less committed to sports activities than typically developing children of the same age. The aim of the present narrative review was to increase the amount of knowledge regarding the effectiveness and importance of specific and individualized sports in children with CP...
March 9, 2024: Medicina
https://read.qxmd.com/read/38540578/perceptions-and-experiences-of-parents-of-burn-injured-children-during-hospital-stay-a-need-for-integrated-care
#18
JOURNAL ARTICLE
Martim Santos, Ana Ferraz, Maria Garcia, M Graça Pereira
Pediatric burn injuries are a critical medical condition that triggers a series of ongoing multifactorial stressors that affect both children and their families. To inform healthcare research and clinical practice, this study aimed to understand and describe the perceptions and experiences of the parents of burn-injured children during hospital stay. Forty-six parents (thirty-eight mothers) of forty-six children (eighteen girls) with a mean age of 2.28 years ( SD = 1.52) answered ten open-ended questions. This qualitative study was conducted in a referral hospital in the northern region of Portugal...
March 8, 2024: Healthcare (Basel, Switzerland)
https://read.qxmd.com/read/38539389/a-comparison-of-the-effects-of-supervised-versus-home-schroth-exercise-programs-with-adolescent-idiopathic-scoliosis
#19
JOURNAL ARTICLE
Kadriye Tombak, İnci Yüksel, Umut Ozsoy, Yılmaz Yıldırım, Sezen Karaşin
(1) Background: Schroth exercise can reduce the deformity of the spine and improve the life quality and the body image of patients with adolescent idiopathic scoliosis (AIS). (2) Methods: The study began with 49 participants, aged 10-16 years old, who were diagnosed with AIS. At the end of the study, 37 patients were randomly assigned to either the Supervised (n = 19) or Home-Based Schroth Exercise Group (n = 18) and completed the study. Both groups were treated for seven days a week over twelve weeks. For all patients, body rotation measurements were performed with a scoliometer, surface asymmetry analysis was carried out using an Artec Eva 3D scanner, health-related quality of life was evaluated by the Scoliosis Research Society-22 (SRS-22) questionnaire, and the perception of the cosmetic deformity was assessed by the Walter Reed Visual Assessment Scale (WRVAS)...
March 17, 2024: Children
https://read.qxmd.com/read/38539381/health-related-quality-of-life-in-relation-to-health-behaviour-patterns-among-canadian-children
#20
JOURNAL ARTICLE
Xiuyun Wu, Arto Ohinmaa, Paul J Veugelers, Katerina Maximova
Poor health behaviours in childhood, including sedentary behaviour, low physical activity levels, inadequate sleep, and unhealthy diet, are established risk factors for both chronic diseases and mental illness. Scant studies have examined the importance of such health behaviour patterns for health-related quality of life (HRQoL). This study aimed to examine the association of health behaviour patterns with HRQoL among Canadian children. Data from 2866 grade five students were collected through a provincially representative school-based survey of the 2014 Raising Healthy Eating and Active Living Kids in Alberta study...
March 14, 2024: Children
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