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Living kidney donation

Steven Habbous, Sisira Sarma, Lianne Barnieh, Eric McArthur, Scott Klarenbach, Braden Manns, Mehmet A Begen, Krista L Lentine, Amit X Garg
BACKGROUND: The health care costs to evaluate, perform surgery, and follow a living kidney donor for the year after donation are poorly described. METHODS: We obtained information on the health care costs of 1099 living kidney donors between April 1, 2004 and March 31, 2014 from Ontario, Canada using comprehensive health care administrative databases. We estimated the cost of 3 periods of the living donation process: the predonation evaluation period (start of evaluation until the day before donation), perioperative period (day of donation until 30-days postdonation), and 1 year of follow-up period (after perioperative period until 1-year postdonation)...
April 19, 2018: Transplantation
I Godinho, J Guerra, M J Melo, M Neves, J Gonçalves, M A Santana, A Gomes da Costa
BACKGROUND: With the rising prevalence of living-donor kidney transplantation, evaluation of factors correlated with renal function in the donor-recipient pair constitutes a main goal for kidney transplantation clinicians. Our objective was to analyze the more relevant donor characteristics that contribute to donor and recipient estimated glomerular filtration rates (eGFR) after 1 year. METHODS: We evaluated 48 consecutive donor-recipient pairs from our unit. RESULTS: Mean donor age was 46 ± 11 years, with 71% being women...
April 2018: Transplantation Proceedings
Bhavini Pisavadia, Adam Arshad, Imogen Chappelow, Peter Nightingale, Benjamin Anderson, Jay Nath, Adnan Sharif
BACKGROUND: Kidneys from non-white donors have inferior outcomes, but it is unclear if ethnicity matching between donors and recipients achieves better post kidney transplant outcomes. METHODS: We undertook a retrospective, population cohort study utilising UK Transplant Registry data. The cohort comprised adult, kidney-alone, transplant recipients receiving their first kidney transplant between 2003-2015, with data censored at 1st October 2016. We included 27,970 recipients stratified into white (n = 23,215), black (n = 1,679) and south Asian (n = 3,076) ethnicity, with median post-transplant follow-up of 1,676 days (IQR 716-2,869 days)...
2018: PloS One
Angelo Territo, Lluis Gausa, Antonio Alcaraz, Mireia Musquera, Nicolas Doumerc, Karel Decaestecker, Liesbeth Desender, Michael Stockle, Martin Janssen, Paolo Fornara, Nasreldin Mohammed, Giampaolo Siena, Sergio Serni, Selcuk Sahin, Volkan Tuǧcu, Giuseppe Basile, Alberto Breda
OBJECTIVES: To evaluate functional results, graft survival, and late complications in patients who underwent robot-assisted kidney transplantation (RAKT), with a minimum follow-up of one year. In addition: to analyze the correlation between surgical data and functional results at a minimum 1-year follow-up and the correlation between renal function in the immediate postoperative period and after one year. MATERIALS AND METHODS: A common prospective recruitment database of RAKT was created by the European Robotic Urological Section (ERUS) RAKT working group, including eight different European centers...
April 12, 2018: BJU International
Katerina Mastrocostas, Christina M Chingkoe, Kenneth T Pace, Joseph J Barfett, Anish Kirpalani, Gevork N Mnatzakanian, Paraskevi A Vlachou, Errol Colak
INTRODUCTION: The purpose of this study was to determine the variety and prevalence of renal and non-renal abnormalities detected on multi-detector computed tomography (MDCT) that precluded patients from donating a kidney. METHODS: Institutional review board approval was obtained and the requirement for informed consent was waived. A retrospective, single-centre review of 701 patients (444 female, 257 male; age range 18-86 years; mean age 43.2±11.9 years) that underwent renal donor protocol MDCT was conducted...
April 6, 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
François Gaillard, Marie Courbebaisse
End-stage renal disease risk of living kidney donors is lower than the one in general population. In 2014, two independent studies confirmed this result but evidenced an increased risk of end-stage renal disease after donation. In this context, long-term consequences of living donation need to be better defined. Evaluation of renal function is a cornerstone of living donor screening. Precise knowledge of kidney donation physiology is required to propose a relevant predonation screening. In this review, we present the risks of donation, the physiology of living donation and discuss international guidelines...
April 2018: Néphrologie & Thérapeutique
Stuart M Flechner, Alvin G Thomas, Matthew Ronin, Jeffrey L Veale, David B Leeser, Sandip Kapur, John D Peipert, Dorry Segev, Macey L Henderson, Ashton A Shaffer, Matthew Cooper, Garet Hil, Amy D Waterman
The practice of kidney paired donation (KPD) is expanding annually, offering the opportunity for live donor kidney transplantation to more patients. We sought to identify if voluntary KPD networks such as the National Kidney Registry (NKR) were selecting or attracting a narrower group of donors or recipients compared to national registries. For this purpose, we merged data from the NKR database with the SRTR database from February 14, 2008 to February 14, 2017, encompassing the first 9 years of the NKR. When compared to all UNOS live donor transplants (49,610), all UNOS living unrelated transplants (23,319), and all other KPD transplants (4,236), the demographic and clinical characteristics of NKR transplants (2,037) appear similar to contemporary national trends...
March 30, 2018: American Journal of Transplantation
Katrina A Bramstedt
This study is a long-term follow-up on the health and quality of life of Good Samaritan living organ donors who donated an average of 10 years ago. Thirteen donors (kidney, liver, and lung) completed 2 surveys. Data from the RAND 36-Item Health Survey showed that for all domains, as well as the physical and mental component summary scales, the Good Samaritan donor outcomes were superior to the general population ( P < .0001). Data from the European Living Donor Satisfaction Survey (EULID) showed that in all 8 theme areas, the donors reported statistically significant positive reactions as compared to negative reactions...
March 2018: Journal of Patient Experience
Steven Habbous, Jennifer Arnold, Mehmet A Begen, Neil Boudville, Matthew Cooper, Christine Dipchand, Stephanie N Dixon, Liane S Feldman, Dariusz Goździk, Martin Karpinski, Scott Klarenbach, Greg A Knoll, Ngan N Lam, Krista L Lentine, Charmaine Lok, Eric McArthur, Susan McKenzie, Matthew Miller, Mauricio Monroy-Cuadros, Chris Nguan, G V Ramesh Prasad, Sebastian Przech, Sisira Sarma, Dorry L Segev, Leroy Storsley, Amit X Garg
BACKGROUND: A prolonged living kidney donor evaluation may result in worse outcomes for transplant recipients. Better knowledge of the duration of this process may help inform future donors and identify opportunities for improvement. STUDY DESIGN: 1 prospective and 1 retrospective cohort study. SETTING & PARTICIPANTS: At 16 Canadian and Australian transplantation centers (prospective cohort) and 5 Ontario transplantation centers (retrospective cohort), we assessed the duration of living kidney donor evaluation and explored donor, recipient, and transplantation factors associated with longer evaluation times...
March 24, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
A J Roldán-Reina, L Martín-Villén, N Palomo-López, V Hannon, D X Cuenca-Apolo, M Adriaensens-Pérez, M Porras-López, Z Ruiz de Azúa-López, Y Corcia-Palomo, J J Egea-Guerrero
In recent years, the broadening of indications for renal transplantation, together with the progressive reduction of donations following brain stem death, has led to living donation being considered in increasing numbers of cases for renal transplantation. To investigate this further, it is necessary to assess the impact it has on the postoperative outcomes in the intensive care unit (ICU). Our group conducted a retrospective, observational, single-center study from 2013 to 2016 to evaluate differences in outcomes between living and cadaveric kidney donation both during ICU admission and total hospitalization...
March 2018: Transplantation Proceedings
L Garcia-Covarrubias, P Prieto-Olivares, A Bahena-Portillo, A Cicero-Lebrija, H Hinojosa-Heredia, L J Fernández-Lopez, C Almeida-Nieto, V J Visag-Castillo, J Carrión-Barrera, I Castro-Ñuco, E Pedraza-Rojas, A Rosas-Herrera, A García-Covarrubias, D Fernández-Angel, H S Diliz-Perez
BACKGROUND: Hand-assisted laparoscopic nephrectomy (HALDN) is currently the procedure of choice for obtaining living donor kidneys for transplantation. In our institution, it has been the standard procedure for 5 years. Previous studies have shown the same function of the graft as that obtained by open surgery, with a lower rate of bleeding and no differences in complications. We sought to demonstrate the experience and safety of HALDN compared with open donor nephrectomy in healthy donors for kidney transplantation...
March 2018: Transplantation Proceedings
L Garcia-Covarrubias, D R Valdéz, L A Bermudez, R Córdoba, F J Avelar, R M Villanueva, D Ortuño, J C Hernández, A García, I Castro
INTRODUCTION: As a pretransplantation evaluation, renal function is determined by the glomerular filtration rate (GFR) with the use of renal scintigraphy (RS) and the estimated glomerular filtration rate (eGFR). To date, there are few studies that correlate renal cortex volume with eGFR determined with renal gammagram (GR) and eGFR by equations (Cockroft-Gault, Modification of Diet in Renal Disease, and Chronic Kidney Disease Epidemiology Collaboration equation) in Latin American living donors...
March 2018: Transplantation Proceedings
L Garcia-Covarrubias, J Barragan, I Castro, K Hernandez, A Reding, H Hinojosa, P Prieto, A Garcia, C Alejandra, D Ortuño, M Carmona, D Fernández, H Diliz
BACKGROUND: Renal donation leads to a risk of developing chronic kidney disease, with an incidence of 0.47%. To evaluate for its presence, formulas based on serum creatinine are used, but up to 80% of these formulas underestimate the glomerular filtration rate (GFR) in donors. The aim of this work was to confirm the highest correlation of the GFR as measured with the use of DTPA-Tc99m with the GFR as estimated by means of the formula based on serum cystatin C (CKD-EPI creatinine-cystatin C) in healthy kidney donors...
March 2018: Transplantation Proceedings
C A Mombelli, M C Giordani, N C Imperiali, S R Groppa, S K Villamil Cortez, C M Schreck, G J Rosa-Diez
INTRODUCTION: Living kidney donor (LKD) transplantation is increasing due to organ shortage. Clinical studies have shown that the risk of developing end-stage renal disease (ESRD) in donors is similar to that in the general population. Our goal was to evaluate postdonation renal outcomes assessed by glomerular filtration rate (GFR), proteinuria, and blood pressure. METHODS: A total of 210 LKD transplants were performed at Hospital Italiano de Buenos Aires between 2000 and 2014...
March 2018: Transplantation Proceedings
A Ríos, A I López-Navas, C De-Francisco, Á Sánchez, A M Hernández, P Ramírez, P Parrilla
BACKGROUND: The attitude toward living kidney donation is important for certain promotion campaigns, however, there are few validated questionnaires in this regard. The aim of this work was to analyze the psychometric characteristics of the attitudes questionnaire about living renal donation, PCID-DVR-Ríos (Cuestionario del Proyecto Colaborativo Internacional Donante sobre Donación de Vivo Renal [Questionnaire of the International Collaborative Donor Project on Living Kidney Donation] developed by Dr Ríos) for the validation of the questionnaire in population of Spanish speakers...
March 2018: Transplantation Proceedings
A Ríos, A I López-Navas, Á Sánchez, M A Ayala, G Garrido, M J Sebastián, J Flores-Medina, L Martinez-Alarcon, G Ramis, A M Hernández, P Ramírez, P Parrilla
BACKGROUND: The Ecuadorian population is the largest Latin-American immigrant group in Spain. Currently, several Ecuadorians have received transplants or are awaiting transplants in Spain. The aim of this work was to analyze the attitude toward living kidney donation among the Ecuadorian population residing in Spain. METHODS: The population screened were born in Ecuador, residing in Spain, and >15 years old, stratified by gender and age, and appraised with the use of the questionnaire on attitude toward organ donation for transplantation "PCID-DVR-Ríos...
March 2018: Transplantation Proceedings
A Ríos, J Carrillo, A I López-Navas, M A Ayala, G Garrido, M J Sebastián, L Martínez-Alarcón, G Ramis, A M Hernández, P Ramírez, P Parrilla
BACKGROUND: The Nigerian population is an emerging group in Spain and in Europe, but their sensitization toward living kidney donation has not been studied. The aim of this work was to analyze the attitude toward related renal donation while alive among the population born in Nigeria resident in Spain. METHODS: A population older than 15 years born in Nigeria and resident in Spain, stratified by age and sex, was studied with the use of the attitude questionnaire about living kidney donation, "PCID-DVR-Ríos...
March 2018: Transplantation Proceedings
A Ríos, J Carrillo, A I López-Navas, L Martínez-Alarcón, M A Ayala, G Garrido, G Ramis, A M Hernández, P Ramírez, P Parrilla
BACKGROUND: Senegalese populations are massively migrating to the southern parts of the European Union, especially Spain, France, and Italy. The attitude towards living kidney donation in this group is little known. The objective of this study was to analyze the attitude toward living kidney donation of subjects from the population of Senegalese residents in Spain. METHODS: The study subjects were the Senegalese population residing in Spain aged >15 years stratified according to age and sex, according to census data and immigrant support associations...
March 2018: Transplantation Proceedings
A Ríos, A I López-Navas, Á Sánchez, M A Ayala, G Garrido, M J Sebastián, L Martinez-Alarcón, G Ramis, A M Hernández, P Ramírez, P Parrilla
INTRODUCTION: The Uruguayan population is sensitized toward transplantation. However, it has not been studied how this awareness can change when emigrating to different countries. OBJECTIVE: To analyze the attitude toward cadaveric organ donation and living organ donation between the Uruguayan population residing in Florida (United States) and the Uruguayan population residing in Spain. METHOD: Adults born in Uruguay and residing in Florida and Spain were screened...
March 2018: Transplantation Proceedings
A Ríos, A I López-Navas, Á Sánchez, L Martínez-Alarcón, M A Ayala, G Garrido, M J Sebastián, G Ramis, A M Hernández, P Ramírez, P Parrilla
INTRODUCTION: Living kidney donation is currently the most important kidney donor source in Latin America, and it is necessary to further increase its rates. OBJECTIVE: To analyze the attitude toward living kidney donation among the Santiago de Cuba's population and to determine the sociopersonal factors with which it is associated. METHOD: The population over 15 years old residing in Santiago de Cuba, stratified by sex and age, was screened...
March 2018: Transplantation Proceedings
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