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Living kidney donation

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https://www.readbyqxmd.com/read/28209606/long-term-experiences-of-norwegian-live-kidney-donors-qualitative-in-depth-interviews
#1
Käthe B Meyer, Ida Torunn Bjørk, Astrid Klopstad Wahl, Annette Lennerling, Marit Helen Andersen
OBJECTIVE: Live kidney donation is generally viewed as a welcome treatment option for severe kidney disease. However, there is a disparity in the body of research on donor experiences and postdonation outcome, and lack of knowledge on long-term consequences described by the donors. This study was conducted to provide insight into donors' subjective meanings and interpretation of their experiences ∼10 years after donation. DESIGN: Qualitative explorative in-depth interviews...
February 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/28202169/setting-the-limit-for-living-kidney-donation-how-big-is-too-big
#2
Germaine Wong, Jonathan C Craig, Jeremy R Chapman
Increasingly, obese and overweight but healthy individuals are being considered for living donation, but the consequences of obesity on long-term health outcomes, including the risk of progression to end-stage kidney disease after donor nephrectomy, are relatively unknown. In this issue, Locke et al. analyzed a large cohort of living kidney donors in the United States, including 26% who were obese, and estimated the attributable and relative risk of end-stage kidney disease over time. Findings from this study challenge the current recommended thresholds for obesity that usually preclude donation, and inform communication regarding risk between clinicians and prospective donors during the donor evaluation process...
March 2017: Kidney International
https://www.readbyqxmd.com/read/28187045/apolipoprotein-l1-and-chronic-kidney-disease-risk-in-young-potential-living-kidney-donors
#3
Jayme E Locke, Deirdre Sawinski, Rhiannon D Reed, Brittany Shelton, Paul A MacLennan, Vineeta Kumar, Shikha Mehta, Roslyn B Mannon, Robert Gaston, Bruce A Julian, John J Carr, James G Terry, Meredith Kilgore, Allan B Massie, Dorry L Segev, Cora E Lewis
OBJECTIVE: The aim of this study was to develop a novel chronic kidney disease (CKD) risk prediction tool for young potential living kidney donors. SUMMARY OF BACKGROUND DATA: Living kidney donor selection practices have evolved from examining individual risk factors to a risk calculator incorporating multiple characteristics. Owing to limited long-term data and lack of genetic information, current risk tools lack precision among young potential living kidney donors, particularly African Americans (AAs)...
February 9, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28186535/long-term-risks-of-kidney-living-donation-review-and-position-paper-by-the-era-edta-descartes-working-group
#4
Umberto Maggiore, Klemens Budde, Uwe Heemann, Luuk Hilbrands, Rainer Oberbauer, Gabriel C Oniscu, Julio Pascual, Soren Schwartz Sorensen, Ondrej Viklicky, Daniel Abramowicz
No abstract text is available yet for this article.
February 1, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28160472/pre-donation-cognitions-of-potential-living-organ-donors-the-development-of-the-donation-cognition-instrument-in-potential-kidney-donors
#5
Lieke Wirken, Henriët van Middendorp, Christina W Hooghof, Jan-Stephan F Sanders, Ruth E Dam, Karlijn A M I van der Pant, Elsbeth C M Berendsen, Hiske Wellink, Henricus J A Dackus, Andries J Hoitsma, Luuk B Hilbrands, Andrea W M Evers
No abstract text is available yet for this article.
February 4, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28152295/dialysis-transplant-living-donation-understanding-kidney-disease-from-those-who-do
#6
Kelli Collins
No abstract text is available yet for this article.
August 2016: Nephrology News & Issues
https://www.readbyqxmd.com/read/28152216/what-is-the-significance-of-esrd-risk-estimation-in-living-kidney-donors
#7
François Gaillard, Stéphanie Baron, Marc-Olivier Timsit, Dominique Eladari, Catherine Fournier, Caroline Prot-Bertoye, Jean-Philippe Bertocchio, Lionel Lamhaut, Gérard Friedlander, Arnaud Méjean, Christophe Legendre, Marie Courbebaisse
BACKGROUND: Two end stage renal disease (ESRD) risk calculators were recently developed by Grams et al, and Ibrahim et al to calculate ESRD risk before donation among living kidney donors. However those calculators have never been studied among potential donors for whom donation was refused due to medical contraindications and compared to a group of donors. METHODS: We compared 15-year and lifetime ESRD risk of donors and non-donors due to medical cause as estimated by those two calculators...
February 2, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28111805/ureteric-complications-in-recipients-of-kidneys-from-donation-after-circulatory-death-donors
#8
Trina-Jo Mah, Dermot H Mallon, Oliver Brewster, Kourosh Saeb-Parsy, Andrew J Butler, J Andrew Bradley, Vasilis Kosmoliaptsis
A large increase in the use of kidneys from donation after circulatory death (DCD) donors prompted us to examine the impact of donor type on the incidence of ureteric complications (UCs; ureteric stenosis, urinary leak) after kidney transplantation. We studied 1072 consecutive kidney transplants [DCD n=494, live-donor (LD) n=273, donation after brain death (DBD) n=305] performed during 2008 to 2014. Overall, there was a low incidence of UCs after kidney transplantation (3.5%). Despite a trend towards higher incidence of UCs in DCD (n=22, 4...
January 23, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28103829/a-comparison-of-the-effects-of-oral-vs-intravenous-hydration-on-subclinical-acute-kidney-injury-in-living-kidney-donors-a-protocol-of-a-randomised-controlled-trial
#9
Shona Mackinnon, Emma Aitken, Ryan Ghita, Marc Clancy
BACKGROUND: Optimal treatment for established renal failure is living donor kidney transplantation. However this pathway exposes healthy individuals to significant reduction in nephron mass via major surgical procedure. Laparoscopic donor nephrectomy is now the most common method for live donor transplantation, reducing both donor post-operative pain and recovery time. However this procedure exposes kidneys to additional haemodynamic stresses. It has been suggested that donor hydration-particularly the use of preoperative intravenous fluids-may counteract these stresses, reducing subclinical acute kidney injury and ultimately improving long-term renal function...
January 19, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28095803/increased-glomerulonephritis-recurrence-after-living-related-donation
#10
A L Kennard, S H Jiang, G D Walters
BACKGROUND: Kidney transplantation confers superior outcomes for patients with end stage kidney disease, and live donor kidneys associate with superior outcomes compared to deceased donor kidneys. Modern immunosuppression has improved rejection rates and transplant survival and, as a result, recurrence of glomerulonephritis has emerged as a major cause of allograft loss. However, many glomerulonephritides have significant genetic risk which may manifest through kidney intrinsic or systemic mechanisms...
January 17, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28058212/complement-related-kidney-diseases-recurrence-after-transplantation
#11
REVIEW
Maurizio Salvadori, Elisabetta Bertoni
The recurrence of renal disease after renal transplantation is becoming one of the main causes of graft loss after kidney transplantation. This principally concerns some of the original diseases as the atypical hemolytic uremic syndrome (HUS), the membranoproliferative glomerulonephritis (MPGN), in particular the MPGN now called C3 glomerulopathy. Both this groups of renal diseases are characterized by congenital (genetic) or acquired (auto-antibodies) modifications of the alternative pathway of complement...
December 24, 2016: World Journal of Transplantation
https://www.readbyqxmd.com/read/28049698/effects-of-reduced-kidney-function-because-of-living-kidney-donation-on-left-ventricular-mass
#12
Ursula Altmann, Carsten A Böger, Stefan Farkas, Matthias Mack, Andreas Luchner, Okka W Hamer, Florian Zeman, Kurt Debl, Claudia Fellner, Carsten Jungbauer, Bernhard Banas, Stefan Buchner
Living kidney donation is associated with a small but significant increase in cardiovascular mortality. In addition, mildly decreased kidney function is associated with an increase of left ventricular mass and with cardiovascular disease in patients with chronic kidney disease. To investigate this association, we evaluated the impact of mildly decreased kidney function after living kidney donation on subclinical cardiac structural and functional changes. In this prospective cohort study, cardiac and renal magnetic resonance imaging and laboratory analyses were performed in 23 living kidney donors (mean age 54±10 years, 52% male) before donation and at 4 and 12 months after nephrectomy...
January 3, 2017: Hypertension
https://www.readbyqxmd.com/read/28041626/obesity-increases-the-risk-of-end-stage-renal-disease-among-living-kidney-donors
#13
Jayme E Locke, Rhiannon D Reed, Allan Massie, Paul A MacLennan, Deirdre Sawinski, Vineeta Kumar, Shikha Mehta, Roslyn B Mannon, Robert Gaston, Cora E Lewis, Dorry L Segev
Determining candidacy for live kidney donation among obese individuals remains challenging. Among healthy non-donors, body mass index (BMI) above 30 is associated with a 16% increase in risk of end-stage renal disease (ESRD). However, the impact on the ESRD risk attributable to donation and living with only one kidney remains unknown. Here we studied the risk of ESRD associated with obesity at the time of donation among 119 769 live kidney donors in the United States. Maximum follow-up was 20 years. Obese (BMI above 30) live kidney donors were more likely male, African American, and had higher blood pressure...
March 2017: Kidney International
https://www.readbyqxmd.com/read/28039956/longitudinal-analysis-of-living-donor-kidney-transplant-rates-in-pediatric-candidates-in-the-united-states
#14
Douglas S Keith, Gayle Vranic, John Barcia, Victoria Norwood, Angie Nishio-Lucar
Among adults, living donor kidney transplant rates began declining in the United States after 2004 but whether a similar decline is occurring in the pediatric candidates has not been well studied. Share 35, a change in allocation rules implemented in October of 2005, may also have influenced rates of living donation. We sought to determine whether a decline in rates was occurring in pediatric candidates and whether the Share 35 program was the cause of the decline. All children listed for a kidney transplant or transplanted with a living donor without listing between 1996 and 2011 were identified in the United States (N=14 911) of which 6046 had received a living donor transplant during follow-up...
December 30, 2016: Pediatric Transplantation
https://www.readbyqxmd.com/read/28024112/left-sided-living-kidney-donation-leads-to-transiently-reduced-adrenocortical-responsiveness
#15
F Burn, C Schirpenbach, M Bidlingmaier, M Reincke, D Vetter, D Weishaupt, J G Brockmann, M K Müller, M Weber, F Dahm, A Nocito
Living kidney donation is safe and established, but can lead to long-term complications such as chronic fatigue. Since the adrenal vein is usually transected during left-sided donor nephrectomy-which is not necessary on the right-we hypothesized that venous congestion might lead to an impairment of adrenal function, offering a possible explanation. In this prospective open label, monocentric cohort study, adrenal function was compared in left- and right-sided living kidney donors. The primary endpoint was plasma cortisol response to low-dose adrenocorticotropic hormone (ACTH) stimulation...
December 26, 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/28018759/could-the-use-of-an-enhanced-recovery-protocol-in-laparoscopic-donor-nephrectomy-be-an-incentive-for-live-kidney-donation
#16
Aparna Rege, Harold Leraas, Deepak Vikraman, Kadiyala Ravindra, Todd Brennan, Tim Miller, Julie Thacker, Debra Sudan
INTRODUCTION AND BACKGROUND: Gastrointestinal (GI) recovery after major abdominal surgery can be delayed from an ongoing need for narcotic analgesia thereby prolonging hospitalization. Enhanced recovery after surgery (ERAS) is a multimodal perioperative care pathway designed to facilitate early recovery after major surgery by maintaining preoperative body composition and physiological organ function and modifying the stress response induced by surgical exposure. Enhanced recovery programs (ERPs) in colorectal surgery have decreased the duration of postoperative ileus and the hospital stay while showing equivalent morbidity, mortality, and readmission rates in comparison to the traditional standard of care...
November 22, 2016: Curēus
https://www.readbyqxmd.com/read/27998880/social-media-use-among-living-kidney-donors-and-recipients-survey-on-current-practice-and-potential
#17
Abby Swanson Kazley, Bashir Hamidi, Wendy Balliet, Prabhakar Baliga
BACKGROUND: In the United States, there is a national shortage of organs donated for transplant. Among the solid organs, most often kidneys are donated by living donors, but the lack of information and complicated processes limit the number of individuals who serve as living kidney donors. Social media can be a tool for advocacy, educating the public about the need, process, and outcomes of live kidney donors, yet little is known about social media use by kidney transplant patients. OBJECTIVE: The purpose of this study was to examine the social media use of potential kidney transplant patients and their willingness to use social media and their networks to advocate and educate about living kidney donation...
December 20, 2016: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/27997071/integrating-apol1-gene-variants-into-renal-transplantation-considerations-arising-from-the-american-society-of-transplantation-expert-conference
#18
K A Newell, R N Formica, J S Gill, J D Schold, J S Allan, S H Covington, A C Wiseman, A Chandraker
Thirteen percent of individuals of African ancestry express two variant copies of the gene encoding apolipoprotein 1 (APOL1) that has been associated with an increased risk of end-stage renal disease (ESRD) in the general population. Limited studies suggest that the survival of transplanted kidneys from donors expressing two APOL1 risk alleles is inferior to that of kidneys from donors with zero or one risk allele. In living kidney donation, two case reports describe donors expressing two APOL1 risk alleles who developed ESRD...
December 20, 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/27994868/outcomes-of-living-kidney-donors-with-medullary-sponge-kidney
#19
Wisit Cheungpasitporn, Charat Thongprayoon, Brady A Brabec, Wonngarm Kittanamongkolchai, Stephen B Erickson
BACKGROUND: Patients with medullary sponge kidney (MSK) commonly encounter recurrent nephrolithiasis. The existing knowledge on safety of donors with MSK has not been studied. METHODS: We conducted a retrospective cohort study at a tertiary referral hospital to assess the outcomes of living kidney donors with MSK. All adults with MSK (N = 26) who underwent nephrectomy as living kidney donors between January 2000 and September 2014 were included. Non-donors with MSK (N = 78) were randomly selected by matching the year of birth and the comorbidity score with a ratio of 1:3 for comparison...
December 2016: Clinical Kidney Journal
https://www.readbyqxmd.com/read/27992110/kidney-exchange-to-overcome-financial-barriers-to-kidney-transplantation
#20
M A Rees, T B Dunn, C S Kuhr, C L Marsh, J Rogers, S E Rees, A Cicero, L J Reece, A E Roth, O Ekwenna, D E Fumo, K D Krawiec, J E Kopke, S Jain, M Tan, S R Paloyo
Organ shortage is the major limitation to kidney transplantation in the developed world. Conversely, millions of patients in the developing world with end-stage renal disease die because they cannot afford renal replacement therapy-even when willing living kidney donors exist. This juxtaposition between countries with funds but no available kidneys and those with available kidneys but no funds prompts us to propose an exchange program using each nation's unique assets. Our proposal leverages the cost savings achieved through earlier transplantation over dialysis to fund the cost of kidney exchange between developed-world patient-donor pairs with immunological barriers and developing-world patient-donor pairs with financial barriers...
November 7, 2016: American Journal of Transplantation
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