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Living kidney donation

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https://www.readbyqxmd.com/read/28333861/vouchers-for-future-kidney-transplants-to-overcome-chronological-incompatibility-between-living-donors-and-recipients
#1
Jeffrey L Veale, Alexander M Capron, Nima Nassiri, Gabriel Danovitch, H Albin Gritsch, Amy Waterman, Joseph Del Pizzo, Jim C Hu, Marek Pycia, Suzanne McGuire, Marian Charlton, Sandip Kapur
BACKGROUND: The waiting list for kidney transplantation is long and growing. The creation of "vouchers" for future kidney transplants enables living donation to occur when optimal for the donor and transplantation to occur later, when and if needed by the recipient. METHODS: The donation of a kidney at a time that is optimal for the donor generates a 'voucher' that only a specified recipient may redeem later when needed. The voucher provides the recipient with priority in being matched with a living donor from the end of a future transplantation chain...
March 22, 2017: Transplantation
https://www.readbyqxmd.com/read/28323892/impact-of-abo-incompatible-kidney-transplantation-on-living-donor-transplantation
#2
Ji Hyun Yu, Byung Ha Chung, Chul Woo Yang
BACKGROUND: ABO incompatible kidney transplantation (ABOi-KT) is an important approach for overcoming donor shortages. We evaluated the effect of ABOi-KT on living donor KT. METHODS: Two nationwide transplantation databases were used. We evaluated the impact of ABOi-KT on overall living donor transplant activity and spousal donation as subgroup analysis. In addition, we compared the clinical outcome between ABOi-KT and ABO compatible KT (ABOc-KT) from spousal donor, and performed a Cox proportional hazards regression analysis to define the risk factors affecting the allograft outcomes...
2017: PloS One
https://www.readbyqxmd.com/read/28321984/reciprocity-to-increase-participation-of-compatible-living-donor-and-recipient-pairs-in-kidney-paired-donation
#3
John S Gill, Kathryn Tinckam, Marie Chantal Fortin, Caren Rose, Kara Shick-Makaroff, Kimberly Young, Julie Lesage, Edward H Cole, Maeghan Toews, David N Landsberg, Jagbir Gill
Inclusion of compatible living donor and recipient pairs (CPs) in kidney paired donation (KPD) programs could increase living donor transplantation. We introduce the concept of a reciprocity based strategy in which the recipient of a CP that participates in KPD receives priority for a repeat deceased donor transplant in the event their primary living donor KPD transplant fails, and review the practical and ethical considerations of this strategy. The strategy limits prioritization to CPs already committed to living donation, minimizing the risk of unduly influencing donor behavior...
March 21, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28319288/impact-of-single-centre-kidney-paired-donation-transplantation-to-increase-the-donor-pool-in-india
#4
Vivek B Kute, Himanshu V Patel, Pankaj R Shah, Pranjal R Modi, Veena R Shah, Sayyed J Rizvi, Bipin C Pal, Priyadarshini S Shah, Manisha P Modi, Beena P Butala, Pavan S Wakhare, Umesh T Varyani, Saiprasad G Shinde, Vijay A Ghodela, Govind S Kasat, Mayur V Patil, Jaideep C Patel, Deepk P Kumar, Varsha B Trivedi, Minaxi H Patel, Hargovind L Trivedi
In a living donor kidney transplantation (LDKT) dominated transplant programme, kidney paired donation (KPD) may be a cost-effective and valid alternative strategy to increase LDKT in countries with limited resources where deceased donation kidney transplantation (DDKT) is in the initial stages. Here, we report our experience of 300 single-centre KPD transplantations to increase LDKT in India. Between January 2000 and July 2016, 3616 LDKT and 561 DDKT were performed at our transplantation centre, 300 (8.3%) using KPD...
March 20, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28298325/gfr-evaluation-in-living-kidney-donor-candidates
#5
Andrew S Levey, Lesley A Inker
Evaluation of GFR, required in the evaluation of living kidney donor candidates, is now receiving increasing emphasis because recent data demonstrate increased risk of kidney disease after donation, including a small increase in the risk of kidney failure. The international guideline development group, Kidney Disease Improving Global Outcomes, recently published a comprehensive set of recommendations for living donor evaluation, with three recommendations regarding GFR. (1) Donor candidacy is evaluated in light of long-term risk, in which GFR is one of many factors...
March 15, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28284304/kidney-paired-exchange-and-desensitization-strategies-to-transplant-the-difficult-to-match-kidney-patients-with-living-donors
#6
REVIEW
Thomas A Pham, Jacqueline I Lee, Marc L Melcher
With organs in short supply, only a limited number of kidney transplants can be performed a year. Live donor donation accounts for 1/3rd of all kidney transplants performed in the United States. Unfortunately, not every donor recipient pair is feasible because of Human leukocyte antigen (HLA) sensitization and ABO incompatibility. To overcome these barriers to transplant, strategies such as kidney paired donation (KPD) and desensitization have been developed. KPD is the exchange of donors between at least two incompatible donor-recipient pairs such that they are now compatible...
January 2017: Transplantation Reviews
https://www.readbyqxmd.com/read/28280697/international-kidney-paired-donation-transplantations-to-increase-kidney-transplant-of-o-group-and-highly-sensitized-patient-first-report-from-india
#7
Vivek B Kute, Himanshu V Patel, Pankaj R Shah, Pranjal R Modi, Veena R Shah, Sayyed J Rizvi, Bipin C Pal, Priya S Shah, Pavan S Wakhare, Saiprasad G Shinde, Vijay A Ghodela, Umesh T Varyani, Minaxi H Patel, Varsha B Trivedi, Hargovind L Trivedi
AIM: To report the first international living related two way kidney paired donation (KPD) transplantation from India which occurred on 17(th) February 2015 after legal permission from authorization committee. METHODS: Donor recipient pairs were from Portugal and India who were highly sensitized and ABO incompatible with their spouse respectively. The two donor recipient pairs had negative lymphocyte cross-matching, flow cross-match and donor specific antibody in two way kidney exchange with the intended KPD donor...
February 24, 2017: World Journal of Transplantation
https://www.readbyqxmd.com/read/28260992/risk-factors-associated-with-decreased-renal-function-after-hand-assisted-laparoscopic-donor-nephrectomy-a-multivariate-analysis-of-a-single-surgeon-experience
#8
Jinwook Lim, Yu-Gyeong Kong, Young-Kug Kim, Bumsik Hong
Background: Hand-assisted laparoscopic donor nephrectomy is a minimally invasive procedure for living kidney donation. The surgeon operative volume is associated with postoperative morbidity and mortality. We evaluated the risk factors associated with decreased renal function after hand-assisted laparoscopic donor nephrectomy performed by a single experienced surgeon. Methods: We included living renal donors who underwent hand-assisted laparoscopic donor nephrectomy by a single experienced surgeon between 2006 and 2013...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28260454/obesity-and-loss-of-kidney-function-two-complications-to-face-for-older-living-kidney-donors
#9
Demet Firat Kaya, Burak Sayin, Hatice Saglam, Bahar Gurlek Demirci, Turan Colak
OBJECTIVES: Although living kidney donors have a minimal lifetime risk of developing end-stage renal disease, long-term complications and physiologic and psychologic sequelae resulting from donation remain unclear because of lack of optimum follow-up after transplant. Here, we evaluated renal function, complications, and physical and mental performance of living kidney donors. MATERIALS AND METHODS: We evaluated 147 patients who donated living kidneys between 1981 and 2012 at Baskent University Hospital...
February 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28260449/living-kidney-donor-cancellation-at-king-hussein-medical-center
#10
Katibh Al-Rabadi, Reham Issa Almardini, Mysoon Hajeer, Mahmood Hendawi, Aiham Hadad
OBJECTIVES: Living-related kidney donation is the main source of renal grafts in Jordan, since kidneys from deceased donors are scarce. Although the Jordanian community accepts the idea of kidney donation to family members, not all potential donors manage to complete the required psychologic and medical evaluations. We review the causes of kidney-donation cancellation and suggest options to increase the number of available organs. MATERIALS AND METHODS: We performed a retrospective chart review of all potential living-related kidney donors at King Hussein Medical Center between January 2008 and June 2016...
February 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28260446/kinetic-glomerular-filtration-rate-estimation-compared-with-other-formulas-for-evaluating-acute-kidney-injury-stage-early-after-kidney-donation
#11
Reza Hekmat, Hamid Eshraghi, Maryam Esmailpour, Golnaz Ghayyem Hassankhani
OBJECTIVES: Kinetic glomerular filtration rate estimation may have more power and versatility than the Modification of Diet in Renal Disease or Cockcroft-Gault formula for evaluating kidney function when plasma creatinine fluctuates rapidly. After kidney donation, glomerular filtration rate rapidly fluctuates in otherwise healthy patients. We compared 3 formulas for estimating glomerular filtration rate: kinetic, Modification of Diet in Renal Disease, and Cockcroft-Gault, for determining stages of acute kidney injury early after kidney donation...
February 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28260444/pediatric-kidney-transplant-experience-at-an-algerian-nephrology-department
#12
Ali Benziane, Saliha Boutennoune
OBJECTIVES: To evaluate the outcomes, complications, causes of graft loss, and patient and graft survival in pediatric renal transplant. MATERIALS AND METHODS: We conducted a retrospective study using the records of 32 children who had a renal transplant between February 2007 and October 2014. RESULTS: All donations were intrafamily, and all patients had a living donor: the patient's mother in 56.3%, the father in 40.6%, and a brother in 3...
February 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28260441/thirty-years-of-experience-at-the-first-tunisian-kidney-transplant-center
#13
Ezzedine Abderrahim, Asma Zammouri, Mohamed Mongi Bacha, Mondher Ounissi, Tahar Gargah, Hafedh Hedri, Riadh Ben Slama, Rafika Bardi, Mohamed Chebil, Taieb Ben Abdallah
OBJECTIVES: The aim of this study was to report the results of 30 years of experience at the first kidney transplant center in Tunisia. MATERIALS AND METHODS: All kidney transplants performed at the center between June 1986 and June 2016 were included. The study period was divided into 3 decades. Recipient and donor data and follow-up information were obtained from a local database and patient medical records. Comparative analyses were performed using the t test for continuous variables and the Χ² test for qualitative variables...
February 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28258071/opting-out-a-single-centre-pilot-study-assessing-the-reasons-for-and-the-psychosocial-impact-of-withdrawing-from-living-kidney-donor-evaluation
#14
Carrie Thiessen, Zainab Jaji, Michael Joyce, Paula Zimbrean, Peter Reese, Elisa J Gordon, Sanjay Kulkarni
Understanding why individuals opt out of living donation is crucial to enhancing protections for all living donors and to identify modifiable barriers to donation. We developed an ethical approach to conducting research on individuals who opted out of living kidney donation and applied it in a small-scale qualitative study at one US transplant centre. The seven study participants (64% response rate) had varied reasons for opting out, the most prominent of which was concern about the financial burden from lost wages during the postoperative period...
March 3, 2017: Journal of Medical Ethics
https://www.readbyqxmd.com/read/28252226/death-of-recipients-after-kidney-living-donation-triples-donors-risk-of-dropping-out-from-follow-up
#15
Xavier Torres, Jordi Comas, Emma Arcos, Jaume Tort, Fritz Diekmann
Although kidney transplantation from the donation of a living donor is a safe treatment for end-stage renal disease, inferences about safety of living kidney donors might be biased by an informative censoring caused by the non-inclusion of a substantial percentage of donors lost-to-follow-up. With the aim of assessing the presence of a potential informative censoring in living kidney donation outcomes of Catalan donors for a period of 12 years, 573 donors followed and lost-to-follow-up were compared. Losses of follow-up over time were also assessed by univariate and multivariate survival analysis, along with Cox regression...
March 2, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28249957/a-case-based-analysis-of-whether-living-related-donors-listed-for-transplant-share-esrd-causes-with-their-recipients
#16
Arthur J Matas, Rebecca E Hays, Hassan N Ibrahim
BACKGROUND AND OBJECTIVES: Two recent studies reported increased risk of ESRD after kidney donation. In both, the majority of ESRD was seen in those donating to a relative. Confounding this observation is that, in the absence of donation, relatives of those with ESRD are at increased risk for ESRD. Understanding the pathogenesis and risk factors for postdonation ESRD is critical for both donor selection and counseling. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We hypothesized that if familial relationship was an important consideration in pathogenesis, the donor and linked recipient would share ESRD etiology...
March 1, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28229801/successful-implantation-of-a-renal-allograft-with-quintuple-arteries-retrieved-from-a-living-donor
#17
Sunil Kumar, Nikhil Mahajan, Soham Dasgupta, Shivakumar Shankarrao Patil, Sarbpreet Singh, Deepesh Benjamin Kenwar, Manphool Singhal, Ashish Sharma, Anupam Lal, Mukut Minz
In renal transplant, multiple renal arteries in a donor require meticulous vascular reconstruction for successful allograft function in the recipient. Presence of more than 4 renal arteries is usually considered to be a relative contraindication for proceeding with renal donation. We report a living-donor renal transplant procedure where preoperative radiologic imaging of the donor showed 3 left renal arteries. Two additional arteries were identified intraoperatively. All 5 arteries were reconstructed during the back-table procedure, and the allograft was implanted in the recipient...
February 23, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28219582/a-study-on-the-directed-living-non-related-donor-kidney-transplantation-submitted-to-the-hospital-transplant-ethics-committee-at-the-national-kidney-and-transplant-institute
#18
G Suguitan, M-H I Arakama, R Danguilan
BACKGROUND: In the latter part of 2009, the Department of Health of the Philippines prohibited kidney transplantation with non-related kidney donors. Hence, the National Kidney and Transplant Institute created a Hospital Transplant Ethics Committee. This study describes directed non-related kidney donation at the National Kidney and Transplant Institute. METHODS: This retrospective study reviewed the profiles of recipients and directed living non-related kidney transplant donors submitted to the Hospital Transplant Ethics Committee...
March 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28209606/long-term-experiences-of-norwegian-live-kidney-donors-qualitative-in-depth-interviews
#19
Käthe B Meyer, Ida Torunn Bjørk, Astrid Klopstad Wahl, Annette Lennerling, Marit Helen Andersen
OBJECTIVE: Live kidney donation is generally viewed as a welcome treatment option for severe kidney disease. However, there is a disparity in the body of research on donor experiences and postdonation outcome, and lack of knowledge on long-term consequences described by the donors. This study was conducted to provide insight into donors' subjective meanings and interpretation of their experiences ∼10 years after donation. DESIGN: Qualitative explorative in-depth interviews...
February 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/28202169/setting-the-limit-for-living-kidney-donation-how-big-is-too-big
#20
Germaine Wong, Jonathan C Craig, Jeremy R Chapman
Increasingly, obese and overweight but healthy individuals are being considered for living donation, but the consequences of obesity on long-term health outcomes, including the risk of progression to end-stage kidney disease after donor nephrectomy, are relatively unknown. In this issue, Locke et al. analyzed a large cohort of living kidney donors in the United States, including 26% who were obese, and estimated the attributable and relative risk of end-stage kidney disease over time. Findings from this study challenge the current recommended thresholds for obesity that usually preclude donation, and inform communication regarding risk between clinicians and prospective donors during the donor evaluation process...
March 2017: Kidney International
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