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Cognition AND serum uric acid

Maria Teresa Pellecchia, Riccardo Savastano, Marcello Moccia, Marina Picillo, Pietro Siano, Roberto Erro, Annamaria Vallelunga, Marianna Amboni, Carmine Vitale, Gabriella Santangelo, Paolo Barone
Cognitive deficits are common in Parkinson's disease (PD) and many patients eventually develop dementia; however, its occurrence is unpredictable. Serum uric acid (UA) has been proposed as a biomarker of PD, both in the preclinical and clinical phase of the disease. The aim of this pilot study was to evaluate relationships between baseline serum UA levels and occurrence of mild cognitive impairment (MCI) at 4-year follow-up in a cohort of early PD patients. Early PD patients, not presenting concomitant diseases, cognitive impairment or treatment possibly interfering with UA levels, underwent neuropsychological testing at baseline and 4-year follow-up...
September 28, 2016: Journal of Neural Transmission
Linli Zhou, Ying Jiang, Cansheng Zhu, Lili Ma, Qiling Huang, Xiaohong Chen
OBJECTIVE: Oxidative stress is involved in the pathogenesis of multiple system atrophy (MSA). The aim of this study is to examine oxidant biomarkers including homocysteine (Hcys), bilirubin, uric acid, lipids, and potential environmental risk factors and to ascertain whether these data correlate with MSA in a Chinese population. METHODS: In this study, serum levels of Hcys, bilirubin, uric acid, and lipids were studied in 55 MSA patients and 76 healthy controls (HCs)...
September 2016: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
Wei-Dong Hu, Jing Chen, Cheng-Jie Mao, Ping Feng, Ya-Ping Yang, Wei-Feng Luo, Chun-Feng Liu
OBJECTIVE: We investigated the relationship between serum cystatin C (CysC) levels and cognitive dysfunction and disease progression in patients with Parkinson disease. BACKGROUND: Previous studies have reported altered CysC levels in neurodegenerative disorders, but only a few studies have explored the role of CysC and its relationship to cognitive dysfunction in Parkinson disease. METHODS: We measured serum levels of CysC, creatinine, urea, and uric acid in 142 patients with Parkinson disease and 146 healthy controls...
September 2016: Cognitive and Behavioral Neurology: Official Journal of the Society for Behavioral and Cognitive Neurology
Manuel Delgado-Alvarado, Belén Gago, Irene Navalpotro-Gomez, Haritz Jiménez-Urbieta, María C Rodriguez-Oroz
Cognitive decline is one of the most frequent and disabling nonmotor features of Parkinson's disease. Around 30% of patients with Parkinson's disease experience mild cognitive impairment, a well-established risk factor for the development of dementia. However, mild cognitive impairment in patients with Parkinson's disease is a heterogeneous entity that involves different types and extents of cognitive deficits. Because it is not currently known which type of mild cognitive impairment confers a higher risk of progression to dementia, it would be useful to define biomarkers that could identify these patients to better study disease progression and possible interventions...
June 2016: Movement Disorders: Official Journal of the Movement Disorder Society
Laura Perna, Ute Mons, Ben Schöttker, Hermann Brenner
BACKGROUND: Several studies reported an association between concentrations of serum uric acid and cognitive function, but the evidence is contradictory. It is known that uric acid is associated with cardiovascular diseases, especially among women. Stratifying by sex and history of cardiovascular disease may clarify whether uric acid is an independent risk factor for cognitive dysfunction. METHODS: A population-based study was conducted in the German State of Saarland...
August 2016: Experimental Gerontology
May A Beydoun, Jose-Atilio Canas, Gregory A Dore, Hind A Beydoun, Ola S Rostant, Marie T Fanelli-Kuczmarski, Michele K Evans, Alan B Zonderman
Uric acid, a waste metabolite among humans, was linked to various cognitive outcomes. We describe sex and age-group specific associations of baseline serum uric acid (SUAbase) and significant change in SUA (ΔSUA: 1 versus 0 = decrease versus no change; 2 versus 0 = increase versus no change) with longitudinal annual rate of cognitive change among a large sample of urban adults. Data from the Healthy Aging in Neighborhoods of Diversity across the Life Span study, 2004-2009 (visit 1) and 2009-2013 (visit 2) were used...
April 21, 2016: Journal of Alzheimer's Disease: JAD
Qian Yao, Guo-Xin Jiang, Zhi-Ming Zhou, Jin-Mei Chen, Qi Cheng
BACKGROUND: Metabolic syndrome (MetS) maybe associated with mild cognitive impairment (MCI). OBJECTIVE: To investigate the relationship between MetS, with its individual or combined components, and MCI among elderly. METHODS: A case-control study was conducted among the elderly aged 65 years and over in a community located in the southwestern suburb of Shanghai, China. The Chinese version of the Mini-Mental Status Examination (C-MMSE) was used to screen subjects with MCI...
2016: Journal of Alzheimer's Disease: JAD
B S Ye, W W Lee, J H Ham, J J Lee, P H Lee, Y H Sohn
BACKGROUND AND PURPOSE: The association of serum uric acid, cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) and longitudinal cognitive decline was evaluated using the AD Neuroimaging Initiative database. METHODS: In 271 healthy subjects, 596 mild cognitive impairment patients and 197 AD patients, serum uric acid and CSF AD biomarkers were measured at baseline, and Mini-Mental State Examination and AD Assessment Scale - Cognitive Subscale (ADAS-cog) were assessed serially (mean duration, 2...
May 2016: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
Diego Santos-García, Pablo Mir, Esther Cubo, Lydia Vela, Mari Cruz Rodríguez-Oroz, Maria José Martí, José Matías Arbelo, Jon Infante, Jaime Kulisevsky, Pablo Martínez-Martín
BACKGROUND: Parkinson's disease (PD) is a progressive neurodegenerative disorder causing motor and non-motor symptoms that can affect independence, social adjustment and the quality of life (QoL) of both patients and caregivers. Studies designed to find diagnostic and/or progression biomarkers of PD are needed. We describe here the study protocol of COPPADIS-2015 (COhort of Patients with PArkinson's DIsease in Spain, 2015), an integral PD project based on four aspects/concepts: 1) PD as a global disease (motor and non-motor symptoms); 2) QoL and caregiver issues; 3) Biomarkers; 4) Disease progression...
2016: BMC Neurology
Aamir A Khan, Terence J Quinn, Jonathan Hewitt, Yuhua Fan, Jesse Dawson
Serum uric acid (sUA) level may be associated with cognitive impairment/dementia. It is possible this relationship varies with dementia subtype, particularly between vascular dementias (VaD) and Alzheimer's (AD) or Parkinson's disease (PDD)-related dementia. We aimed to present a synthesis of all published data on sUA and relationship with dementia/cognition through systematic review and meta-analysis. We included studies that assessed the association between sUA and any measure of cognitive function or a clinical diagnosis of dementia...
February 2016: Age (2005-)
Li Feng, Hong-wei Wu, Guang-qing Song, Cong Lu, Ying-hui Li, Li-na Qu, Shan-guang Chen, Xin-min Liu, Qi Chang
Good sleep is necessary for optimal health, especially for mental health. Insomnia, sleep deprivation will make your ability to learn and memory impaired. Nevertheless, the underlying pathophysiological mechanism of sleep disorders-induced cognitive decline is still largely unknown. In this study, the sleep deprivation of animal model was induced by chronical sleep interruption (CSI), the behavioral tests, biochemical index determinations, and a liquid chromatography-mass spectrometry (LC-MS) based serum metabolic profiling analysis were performed to explore the effects of CSI on cognitive function and the underlying mechanisms...
April 1, 2016: Behavioural Brain Research
Dan Chen, Xiaobo Wei, Jing Zou, Rui Wang, Xu Liu, Xiaofeng Xu, Jianjun Lu, Zhanhang Wang, Beisha Tang, Brian Wang, Kunlin Jin, Qing Wang
HIGHLIGHTS: Serum Hcy was higher in MSA patients when compared to healthy subjects, particularly in male patients.Serum UA was lower in MSA patients when compared healthy subjects, particularly in male patients.Serum Hcy levels were significantly positively correlated with the severity of MSA.The ROC curve for the combination of Hcy and UA showed potential diagnostic value in discriminating MSA from healthy subjects. AIM: There is evidence suggesting that inflammatory responses play a critical role in the pathogenesis of multiple system atrophy (MSA)...
2015: Frontiers in Cellular Neuroscience
Edna Méndez-Hernández, José Salas-Pacheco, Luis Ruano-Calderón, Alfredo Téllez-Valencia, Jorge Cisneros-Martínez, Marcelo Barraza-Salas, Oscar Arias-Carrión
Uric acid has been associated as a risk factor for cardiovascular disease. Recently, however, there is growing evidence that uric acid plays a role as antioxidant in the brain. In cognitive dysfunction, vascular and oxidative stress mechanisms play a role, but the link remains unknown. Therefore, we investigated the link between serum uric acid-levels and cognitive function in 62 elderly subjects. The statistical analysis was adjusted to age, sex and cardiovascular risk factors. Here, we found that lower serum uric acid levels are linked to cognitive dysfunction...
2015: CNS & Neurological Disorders Drug Targets
Noa Molshatzki, Galit Weinstein, Jonathan Y Streifler, Uri Goldbourt, David Tanne
High serum uric acid (UA) levels are associated with numerous vascular risk factors, and vascular disease, that predispose patients to cognitive impairment, yet UA is also a major natural antioxidant and higher levels have been linked to slower progression of several neurodegenerative disease. In-order to test the association between UA and subsequent cognitive performance among patients that carry a high vascular burden, UA levels were determined by calorimetric enzymatic tests in a sub-cohort of patients with chronic cardiovascular disease who previously participating in a secondary prevention trial...
2015: PloS One
Haruna Sanke, Tomoya Mita, Hidenori Yoshii, Ayako Yokota, Keiko Yamashiro, Noriko Ingaki, Tomio Onuma, Yuki Someya, Koji Komiya, Yoshifumi Tamura, Tomoaki Shimizu, Chie Ohmura, Akio Kanazawa, Yoshio Fujitani, Hirotaka Watada
AIMS: Recent clinical studies identified the relation between olfactory dysfunction and cognitive impairment in the elderly without type 2 diabetes mellitus. The aim of the present study was to define the relation between olfactory function and cognition in elderly patients with type 2 diabetes mellitus. METHODS: The study participants comprised 250 elderly (age, 68-77, median 72) Japanese outpatient with type 2 diabetes mellitus free of clinically-evident cognitive impairment...
December 2014: Diabetes Research and Clinical Practice
Tracy D Vannorsdall, Alexandra M Kueider, Michelle C Carlson, David J Schretlen
Serum uric acid is a powerful antioxidant that may have neuroprotective properties. While some studies have found that greater serum uric acid is associated with better cognition in older adults, it is also associated with numerous vascular risk factors that increase risk for dementia. Women may also be particularly vulnerable to the vascular effects of elevated uric acid. We previously found that mildly elevated serum uric acid is a biomarker of cognitive dysfunction in older adults, and that this likely is mediated by cerebral ischemic burden...
December 2014: Experimental Gerontology
Juping Chen, Jianxin Yao, Yan Wu, Yun Chen, Chengjie Mao, Chunfeng Liu
OBJECTVE: To explore the incidence of cognitive dysfunction and associated factors in 62 essential tremor (ET) cases, 60 normal controls and 61 Parkinson's disease (PD) cases. METHODS: A total of 62 ET and 61 PD patients from September 2009 to September 2013 were recruited from our outpatient clinic. ET patients received the Tremor Rating Scale for Tremor-motor examination (items 1-15 of rating scale) while 61 PD patients were examined with the Unified Parkinson's Disease Rating Scale (UPDRS)-motor examination and a modified Hoehn and Yahr scale for staging disorder severity...
August 19, 2014: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Eman Al-khateeb, Arwa Althaher, Mohammed Al-khateeb, Hanan Al-Musawi, Ola Azzouqah, Samir Al-Shweiki, Yanal Shafagoj
BACKGROUND: It has been suggested that oxidative injuries have a role in the pathogenesis of Alzheimer's disease (AD). Uric acid (UA) has a contradictory effect on cognitive function and several lines of evidence suggest that UA may modulate outcome in neurological diseases. OBJECTIVES: Many studies investigated serum UA levels in AD patients, but to date, results from these observational studies are conflicting. In this study, we assess whether serum UA levels would be altered in the AD Jordanian patients compared to those of the healthy controls...
2015: Journal of Alzheimer's Disease: JAD
Malahat Mousavi, Pär Jonsson, Henrik Antti, Rolf Adolfsson, Annelie Nordin, Jan Bergdahl, Kåre Eriksson, Thomas Moritz, Lars-Göran Nilsson, Lars Nyberg
AIMS: This study compared serum metabolites of demented patients (Alzheimer's disease and vascular dementia) and controls, and explored serum metabolite profiles of nondemented individuals 5 years preceding the diagnosis. METHODS: Cognitively healthy participants were followed up for 5-20 years. Cognitive assessment, serum sampling, and diagnosis were completed every 5 years. Multivariate analyses were conducted on the metabolite profiles generated by gas chromatography/time-of-flight mass spectrometry...
May 2014: Dementia and Geriatric Cognitive Disorders Extra
Arrigo Francesco Giuseppe Cicero, Giovambattista Desideri, Giulia Grossi, Riccardo Urso, Martina Rosticci, Sergio D'Addato, Claudio Borghi
Contrasting evidence shows a possible association between serum uric acid (SUA) and cognitive function in elderly subjects. We aimed at evaluating the impact of circulating SUA levels on cognitive function in a cohort of pharmacologically untreated young elderly subjects. For this study, we selected 288 healthy young elderly participants from the historical cohort of the Brisighella Heart Study (M: 108, F: 180; mean age: 69 ± 6 years old). Exclusion criteria were limitation of activities of daily living, depression, chronic pharmacological treatment, patients in secondary prevention for cardiovascular disease, known neurodegenerative disorders, confirmed diabetes or gout, and ultrasonic evaluated carotid atherosclerosis...
February 2015: Internal and Emergency Medicine
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