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https://www.readbyqxmd.com/read/29055287/efficacy-and-tolerability-of-high-dose-pelargonium-extract-in-patients-with-the-common-cold
#1
David S Riley, Viktor G Lizogub, Andrea Zimmermann, Petra Funk, Walter Lehmacher
Context • The common cold (CC) is usually caused by a viral infection. Antibiotics are often prescribed unnecessarily for it, although no evidence exists for any benefit in the CC. Effective alternatives are needed. Objective • The study intended to evaluate the efficacy of 7630, a proprietary extract of Pelargonium sidoides, the active ingredient in umckaloabo, compared with a placebo for the treatment of the CC. Design • This was a prospective, double-blind, parallel-group, placebo-controlled, phase 3 clinical trial (RCT), with an adaptive group-sequential design with 2 parts, both of which were 2-arm trials...
October 21, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/29055243/physiological-vital-sign-ranges-in-newborns-from-34-weeks-gestation-a-systematic-review
#2
REVIEW
Michelle Paliwoda, Karen New, Mark Davies, Fiona Bogossian
CONTEXT: The birth process and the moments thereafter are a crucial time for newborns as they adapt to extra uterine life. The adaptive process begins immediately and can take a number of days to complete. The process involves initiating and maintaining respirations, thermoregulation, and the change from foetal circulation to newborn circulation. The majority of newborns successfully adapt to extra uterine life, some experience difficulty. Early warning tools may assist clinicians identify early signs of failure to adapt and/or deterioration but these are dependent on 'Normal' vital sign reference ranges for triggering an escalation of care...
October 9, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29055241/comparing-parent-and-child-reports-of-health-related-quality-of-life-and-their-relationship-with-leisure-participation-in-children-and-adolescents-with-cerebral-palsy
#3
Egmar Longo, Marta Badia, M Begoña Orgaz, María Gómez-Vela
The aim of this study was to examine the level of agreement between reports of health-related quality of life (HR-QoL) obtained from children and adolescents with cerebral palsy (CP) and their parents. We also examined the relationships between child and parent perception of the different domains of HR-QoL and participation dimensions. Sixty-nine children and adolescents with CP and their parents separately completed parallel forms of the KIDSCREEN questionnaire. The Spanish version of the Children's Assessment of Participation and Enjoyment (CAPE) was completed by the child/adolescent...
October 17, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29055092/crown-initiative-and-preterm-birth-prevention-researchers-and-editors-commit-to-implement-core-outcome-sets
#4
J van 't Hooft, Z Alfirevic, E V Asztalos, J R Biggio, L Dugoff, M Hoffman, G Lee, B W Mol, R C Pacagnella, E Pajkrt, G R Saade, A H Shennan, C Vayssière, K S Khan
The emphasis on research quality has taken great strides in recent years. Publication of clinical trial protocols (i.e. SPIRIT guideline), prospective registration (e.g. ClinicalTrials. gov, WHO registry), high standards in research conduct (i.e. ICH-Good Clinical Practice guidelines) and transparent reporting of the findings (i.e. CONSORT guideline) are all becoming features of clinical effectiveness research. However, many more gains are possible to improve the efficiency of clinical research and therefore reduction of waste in health research, a problem that is estimated to consume 85% of the global medical research budget each year...
October 21, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29054883/the-role-of-patient-and-physician-advocacy-in-reducing-wait-times-for-cancer-care-a-qualitative-analysis
#5
Maria Mathews, Donna Bulman, Dana Ryan
BACKGROUND: There is growing interest in the role of physician as health advocate; however, few studies have documented advocacy from the patient's perspective. To address this gap, we examined the experiences of patients with cancer from the onset of symptoms to the start of treatment in Newfoundland and Labrador and aimed to describe wait times and efforts to improve timeliness of care from the patients' perspective. METHODS: We conducted qualitative interviews with 60 participants aged 19 years or more with breast, colorectal, lung or prostate cancer who were recruited from a survey of patients with cancer that was carried out as an earlier part of a larger study...
October 17, 2017: CMAJ Open
https://www.readbyqxmd.com/read/29054831/web-based-information-on-the-treatment-of-tobacco-dependence-for-oral-health-professionals-analysis-of-english-written-websites
#6
Márcio Diniz-Freitas, Angel Insua, Ross Keat, Jean Christophe Fricain, Sylvain Catros, Luis Monteiro, Luis Silva, Giovanni Lodi, Alberto Pispero, Rui Albuquerque
BACKGROUND: Studies have been conducted on the content and quality of Web-based information for patients who are interested in smoking cessation advice and for health care practitioners regarding the content of e-learning programs about tobacco cessation. However, to the best of our knowledge, there is no such information about the quality of Web-based learning resources regarding smoking cessation dedicated to oral health professionals. OBJECTIVE: The aim of this study was to identify and evaluate the quality of the content of webpages providing information about smoking cessation for oral health care professionals...
October 20, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29054789/cost-effectiveness-of-pre-exposure-prophylaxis-for-hiv-prevention-in-men-who-have-sex-with-men-in-the-uk-a-modelling-study-and-health-economic-evaluation
#7
Valentina Cambiano, Alec Miners, David Dunn, Sheena McCormack, Koh Jun Ong, O Noel Gill, Anthony Nardone, Monica Desai, Nigel Field, Graham Hart, Valerie Delpech, Gus Cairns, Alison Rodger, Andrew N Phillips
BACKGROUND: In the UK, HIV incidence among men who have sex with men (MSM) has remained high for several years, despite widespread use of antiretroviral therapy and high rates of virological suppression. Pre-exposure prophylaxis (PrEP) has been shown to be highly effective in preventing further infections in MSM, but its cost-effectiveness is uncertain. METHODS: In this modelling study and economic evaluation, we calibrated a dynamic, individual-based stochastic model, the HIV Synthesis Model, to multiple data sources (surveillance data provided by Public Health England and data from a large, nationally representative survey, Natsal-3) on HIV among MSM in the UK...
October 17, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29054671/impacts-of-rapid-urbanization-on-the-water-quality-and-macroinvertebrate-communities-of-streams-a-case-study-in-liangjiang-new-area-china
#8
Kun Luo, Xuebin Hu, Qiang He, Zhengsong Wu, Hao Cheng, Zhenlong Hu, Asit Mazumder
Rapid urbanization in China has dramatically deteriorated the water quality of streams and threatening aquatic ecosystem health. This study aims to 1) assess the impacts of urbanization on water quality and macroinvertebrate composition and 2) address the question of how urbanization affects macroinvertebrate distribution patterns. Environmental variables over multispatial scales and macroinvertebrate community data were collected on April (dry season) and September (wet season) of 2014 and 2015 at 19 sampling sites, of which nine had a high urbanization level (HUL), six had moderate urbanization level (MUL) and four had low urbanization level (LUL), in the Liangjiang New Area...
October 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29054635/emissions-of-volatile-organic-compounds-vocs-from-cooking-and-their-speciation-a-case-study-for-shanghai-with-implications-for-china
#9
Hongli Wang, Zhiyuan Xiang, Lina Wang, Shengao Jing, Shengrong Lou, Shikang Tao, Jing Liu, Mingzhou Yu, Li Li, Li Lin, Ying Chen, Alfred Wiedensohler, Changhong Chen
Cooking emission is one of sources for ambient volatile organic compounds (VOCs), which is deleterious to air quality, climate and human health. These emissions are especially of great interest in large cities of East and Southeast Asia. We conducted a case study in which VOC emissions from kitchen extraction stacks have been sampled in total 57 times in the Megacity Shanghai. To obtain representative data, we sampled VOC emissions from kitchens, including restaurants of seven common cuisine types, canteens, and family kitchens...
October 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29054620/impact-of-treated-wastewater-for-irrigation-on-soil-microbial-communities
#10
A M Ibekwe, A Gonzalez-Rubio, D L Suarez
The use of treated wastewater (TWW) for irrigation has been suggested as an alternative to use of fresh water because of the increasing scarcity of fresh water in arid and semiarid regions of the world. However, significant barriers exist to widespread adoption due to some potential contaminants that may have adverse effects on soil quality and or public health. In this study, we investigated the abundance and diversity of bacterial communities and the presence of potential pathogenic bacterial sequences in TWW in comparison to synthetic fresh water (SFW) using pyrosequencing...
October 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29054594/what-can-be-achieved-with-a-single-payer-nhi-system-the-case-of-taiwan
#11
William C Hsiao, Shou-Hsia Cheng, Winnie Yip
The United Nations has incorporated the noble goal of Universal Health Coverage (UHC) in its 2030 Agenda for Sustainable Development. Most nations have already embraced UHC as their goal. However, an intense policy debate has risen about which health system structure can best achieve UHC. Is a single-payer system more efficient, equitable and effective than a multiple-payer system for middle income countries? We argue that empirical evidence and in-depth analysis of single-payer and multiple-payer systems should inform this debate...
December 7, 2016: Social Science & Medicine
https://www.readbyqxmd.com/read/29054589/baseline-asthma-burden-comorbidities-and-biomarkers-in-omalizumab-treated-patients-in-prospero
#12
Bradley E Chipps, Robert S Zeiger, Allan T Luskin, William W Busse, Benjamin L Trzaskoma, Evgeniya N Antonova, Hooman Pazwash, Susan L Limb, Paul G Solari, Noelle M Griffin, Thomas B Casale
BACKGROUND: Patients included in clinical trials do not necessarily reflect the real-world population. OBJECTIVE: To understand the characteristics, including disease and comorbidity burden, of patients with asthma receiving omalizumab in a real-world setting. METHODS: The Prospective Observational Study to Evaluate Predictors of Clinical Effectiveness in Response to Omalizumab (PROSPERO) was a US-based, multicenter, single-arm, and prospective study...
October 17, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29054405/standardized-extract-of-bacopa-monnieri-cdri-08-effect-on-germ-cell-dynamics-and-possible-mechanisms-of-its-beneficial-action-on-spermatogenesis-and-sperm-quality-in-male-mice
#13
Shishir Kumar Patel, Shilpi Singh, Shio Kumar Singh
Bacopa monnieri (BM) is used in traditional medicine as nerve tonic. We have recently shown that CDRI-08, a standardized extract of BM, improves testicular functions and epididymal sperm quality in Parkes (P) mice. The aim of the present study was to investigate the effect of CDRI-08 on germ cell dynamics and mechanisms of its action on spermatogenesis and sperm quality in P mice, and to determine the chemical profile of the extract. CDRI-08 (40 and 80 mg/kg body weight) was orally administered to male mice for 28 days...
October 17, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29054347/defining-the-%C3%A2-frequent-exacerbator-%C3%A2-phenotype-in-copd-a-hypothesis-free-approach
#14
Olivier Le Rouzic, Nicolas Roche, Alexis B Cortot, Isabelle Tillie-Leblond, Frédéric Masure, Thierry Perez, Isabelle Boucot, Latifa Hamouti, Juliette Ostinelli, Céline Pribil, Christine Poutchnine, Stéphane Schück, Mathilde Pouriel, Bruno Housset
BACKGROUND: The COPD frequent exacerbator phenotype is usually defined by at least 2 treated exacerbations per year and is associated with a huge impact on patient health. However, existence of this phenotype and corresponding threshold still need to be formally confirmed by statistical methods analysing exacerbations profiles with no specific a priori hypothesis. OBJECTIVE: To confirm the existence of the frequent exacerbator phenotype with an innovative unbiased statistical analysis of prospectively recorded exacerbations...
October 17, 2017: Chest
https://www.readbyqxmd.com/read/29054310/etiology-diagnosis-and-demographic-analysis-of-maxillofacial-trauma-in-elderly-persons-a-10-year-investigation
#15
Anna Paula da Rosa Possebon, Gabriela Granke, Fernanda Faot, Luciana de Rezende Pinto, Fábio Renato Manzolli Leite, Marcos Antonio Torriani
PURPOSE: The aim of this study was to investigate etiologies and diagnoses of maxillofacial trauma in emergency services in Brazil over a period of 10 years. Additionally, associations among sex, age, accident location, and dependent variables were analyzed. Understanding the epidemiology of trauma and the physiology of aging is important in maintaining health and bettering service for the elderly population. MATERIALS AND METHODS: The primary mode of investigation was analysis of medical records from 2003 to 2013...
September 19, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29054122/assessing-the-reporting-quality-of-influenza-outbreaks-in-the-community
#16
Calvin Lo, Dominik Mertz, Mark Loeb
BACKGROUND: High quality reporting of outbreak characteristics is fundamental to understand the behavior of various strains of influenza virus and the impact of outbreak management strategies. However, few studies have systematically evaluated the quality of outbreak reporting. OBJECTIVES: To conduct a systematic analysis and assessment for reporting quality of influenza outbreaks based on a modified version of the STROBE statement, and to examine characteristics associated with reporting quality...
October 20, 2017: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29054099/examining-factors-associated-with-elevated-lie-scale-responding-on-the-child-abuse-potential-inventory
#17
Amanda H Costello, Natalie J Shook, Nancy M Wallace, Cheryl B McNeil
Child maltreatment remains a serious public health issue in the United States. Therefore, it is important to engage in quality control of the assessment, prevention, and treatment services for families affected by maltreatment. Parenting capacity assessments (PCAs) are typically an integral part of service delivery for families affected by maltreatment and can carry serious consequences for the referred parent. The Child Abuse Potential Inventory (CAPI) is a measure that is widely used in PCAs; however, socially desirable responding on the CAPI can serve to invalidate the important information derived from this assessment, as well as lead to negative impressions of the parent...
October 17, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29054087/using-local-knowledge-and-sustainable-transport-to-promote-a-greener-city-the-case-of-bucharest-romania
#18
Mihai R Niță, Denisa L Badiu, Diana A Onose, Athanasios A Gavrilidis, Simona R Grădinaru, Irina I Năstase, Raffaele Lafortezza
Cities undergoing climate change and rapid urbanization are faced with significant transformational processes that affect the environment and society, challenging them to become more sustainable and resilient. The promotion of nature-based solutions represents an efficient approach to meet sustainability targets in cities and improve the quality of life of citizens. The association of large components of green infrastructure, such as urban parks, with physical activity can counteract the sedentary lifestyle endemic to cities and improve the overall health and well-being of individuals (Carrus et al...
October 17, 2017: Environmental Research
https://www.readbyqxmd.com/read/29054016/job-burnout-predicts-decline-of-health-related-quality-of-life-among-employees-with-cardiovascular-disease-a-one-year-follow-up-study-in-female-nurses
#19
Min Zhang, Adrian Loerbroks, Jian Li
OBJECTIVE: To examine whether job burnout is associated with health-related quality of life (HRQOL) in employees with cardiovascular disease. METHODS: In this longitudinal study, we included 305 female hospital nurses with cardiovascular disease. Job burnout was measured by the 6-item Copenhagen Burnout Inventory at baseline. We categorized study participants into low, intermediate and high levels of job burnout based on tertiles. HRQOL at baseline and at one-year follow-up was operationalized in terms of the physical and mental functioning summary scores of the short form 8-item health survey (SF-8), which is an abbreviated version of the widely used SF-36 with score ranges of 0-100...
October 17, 2017: General Hospital Psychiatry
https://www.readbyqxmd.com/read/29053896/quality-and-reporting-of-guidelines-on-the-diagnosis-and-management-of-dystonia
#20
Gertrúd Tamás, Catarina Abrantes, Anabela Valadas, Péter Radics, Alberto Albanese, Marina A J Tijssen, Joaquim J Ferreira
BACKGROUND: The quality of clinical practice guidelines on dystonia has not yet been assessed. Our aim was to appraise the methodological quality of guidelines worldwide and analyze the consistency of their recommendations. METHODS: We searched for clinical practice guidelines on dystonia diagnosis/treatment in the National Guideline Clearinghouse, PubMed, National Institute for Health and Care Excellence, Guidelines International Network and Web of Science databases...
October 20, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
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