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https://www.readbyqxmd.com/read/29471574/-type-2-diabetes-diabetes-in-older-adults-example-for-patient-centered-drug-therapy
#1
Dirk Müller-Wieland
Diabetes in older adults has a high prevalence and is frequently associated with comorbidities of the cardiovascular system, dysfunction of cognition as well as depression and impaired mobility or increased frailty. Furthermore, impaired renal function, heart failure, risk for hypoglycemia and polypharmacy has to be considered in the decision about the diabetes treatment strategy. The goal of blood glucose management is driven by patient relevant issues and patient self-esteem, quality of life defined by the patient, preservation of physical and social mobility rather than potential long-term effects on reduction of cardio- and microvascular events in the future, which is limited by patient-inherent reduced life expectancy of the aged individual...
February 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29471533/reproducibility-of-work-ability-and-work-functioning-instruments
#2
A van Schaaijk, K Nieuwenhuijsen, M H W Frings-Dresen, J K Sluiter
Background: Work ability (WA) and work functioning (WF) instruments can be useful in occupational health practice. The reproducibility of both instruments is important to their relevance for daily practice. Clinimetrics concerns the methodological and statistical quality of instruments and their performance in practice. Aims: To assess the reproducibility of WA and WF instruments. Methods: Dutch workers completed a questionnaire containing WA questions and the WF questionnaire twice with a 7-day interval between...
February 17, 2018: Occupational Medicine
https://www.readbyqxmd.com/read/29471477/feasibility-of-smartphone-application-and-social-media-intervention-on-breast-cancer-survivors-health-outcomes
#3
Zachary Pope, Jung Eun Lee, Nan Zeng, Hee Yun Lee, Zan Gao
Breast cancer survivors are at risk for poor health, with physical activity a possible treatment. Little research has examined how technology might promote breast cancer survivor physical activity or health. The aim of this study is to investigate the feasibility of employing a commercially available mobile health application- and social media-based health education intervention to improve breast cancer survivor physical activity or health.Ten breast cancer survivors (X̅ age = 45.80 ± 10.23 years; X̅ weight = 79...
February 17, 2018: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/29471460/coaching-primary-care-clinics-for-hpv-vaccination-quality-improvement-comparing-in-person-and-webinar-implementation
#4
William A Calo, Melissa B Gilkey, Jennifer Leeman, Jennifer Heisler-MacKinnon, Chrystal Averette, Stephanie Sanchez, Melanie L Kornides, Noel T Brewer
State health departments commonly use quality improvement coaching as an implementation strategy for improving low human papillomavirus (HPV) vaccination coverage, but such coaching can be resource intensive. To explore opportunities for improving efficiency, we compared in-person and webinar delivery of coaching sessions on implementation outcomes, including reach, acceptability, and delivery cost. In 2015, we randomly assigned 148 high-volume primary care clinics in Illinois, Michigan, and Washington State to receive either in-person or webinar coaching...
February 20, 2018: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/29471366/loss-of-trust-in-the-neighborhood-the-experience-of-older-african-americans-in-detroit
#5
Heather Fritz, Malcolm P Cutchin, Emily R Cummins
Objective: Although evidence suggests that neighborhood conditions are related to stress and health, the processes connecting neighborhood conditions and stress for older minorities is little explored. The purpose of this analysis is to contribute new insights into this issue. Method: We conducted a qualitative analysis as part of a larger mixed methods study of 100 African Americans aged 55 and older living in neighborhoods of varying quality in Detroit, Michigan...
February 19, 2018: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/29471330/converging-and-diverging-needs-between-patients-and-providers-who-are-collecting-and-using-patient-generated-health-data-an-integrative-review
#6
Meghan J Reading, Jacqueline A Merrill
Objective: This integrative review identifies convergent and divergent areas of need for collecting and using patient-generated health data (PGHD) identified by patients and providers (i.e., physicians, nurses, advanced practice nurses, physician assistants, and dietitians). Methods: A systematic search of 9 scholarly databases targeted peer-reviewed studies published after 2010 that reported patients' and/or providers' needs for incorporating PGHD in clinical care...
February 17, 2018: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29471323/what-s-to-be-done-about-laboratory-quality-process-indicators-laboratory-stewardship-the-outcomes-problem-risk-assessment-and-economic-value-responding-to-contemporary-global-challenges
#7
Frederick A Meier, Tony C Badrick, Kenneth A Sikaris
Objectives: For 50 years, structure, process, and outcomes measures have assessed health care quality. For clinical laboratories, structural quality has generally been assessed by inspection. For assessing process, quality indicators (QIs), statistical monitors of steps in the clinical laboratory total testing, have proliferated across the globe. Connections between structural and process laboratory measures and patient outcomes, however, have rarely been demonstrated. Methods: To inform further development of clinical laboratory quality systems, we conducted a selective but worldwide review of publications on clinical laboratory quality assessment...
February 17, 2018: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29471308/reporting-guidelines-for-oncology-research-helping-to-maximise-the-impact-of-your-research
#8
REVIEW
Angela MacCarthy, Shona Kirtley, Jennifer A de Beyer, Douglas G Altman, Iveta Simera
Many reports of health research omit important information needed to assess their methodological robustness and clinical relevance. Without clear and complete reporting, it is not possible to identify flaws or biases, reproduce successful interventions, or use the findings in systematic reviews or meta-analyses. The EQUATOR Network (http://www.equator-network.org/) promotes responsible reporting and the use of reporting guidelines to improve the accuracy, completeness, and transparency of health research. EQUATOR supports researchers by providing online resources and training...
February 22, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29471256/consensus-research-priorities-for-paediatric-status-epilepticus-a-delphi-study-of-health-consumers-researchers-and-clinicians
#9
Jeremy Furyk, Robin Ray, Kerriane Watt, Stuart R Dalziel, Ed Oakely, Mark Mackay, Gabriel Dabscheck, Kate Riney, Franz E Babl
PURPOSE: Status epilepticus (SE) is a paediatric emergency with significant morbidity and mortality. Recommendations beyond first line care are not based on high quality evidence. Emergency physicians and neurologists are key stakeholders in managing this condition. A collaborative, widely consulted approach to identifying priorities can help direct limited research funds appropriately. The objectives of this study are to identify consensus research priorities in paediatric SE among experts and health consumers...
February 5, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29471207/locomotive-function-and-quality-of-life-among-older-people-in-liaoning-china-falls-efficacy-as-mediator-or-moderator
#10
Li-Jie Huang, You-Feng Wen, Yong-Chuang Liu, Li-Na Guo, Wen-Ting Du, Min-Min Qin, Jing-Jing Zhang, Kun Liu
OBJECTIVES: This study aimed to examine the role of falls efficacy in the relationship between the locomotive function and quality of life. METHODS: From March to May in 2016, we conducted a cross-sectional survey among 830 community residents aged ≥60 years from Jinzhou,China.GLFS-25 (25-question Geriatric Locomotive Function Scale), FES-I(International edition of Falls Efficacy Scale),and SF-12 (12-item Short Form Health Survey) were used to estimate locomotive function, falls efficacy and quality of life, respectively...
February 9, 2018: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29471124/methods-and-procedures-for-a-randomized-double-blind-study-investigating-dose-dependent-longitudinal-effects-of-vitamin-d-supplementation-on-bone-health
#11
Lauren A Burt, Sharon Gaudet, Michelle Kan, Marianne S Rose, Emma O Billington, Steven K Boyd, David A Hanley
The optimum dose of vitamin D and corresponding serum 25-hydroxyvitamin D (25OHD) concentration for bone health is still debated and some health practitioners are recommending doses well above the Canada/USA recommended Dietary Reference Intake (DRI). We designed a three-year randomized double-blind clinical trial investigating whether there are dose-dependent effects of vitamin D supplementation above the Dietary Reference Intake (DRI) on bone health. The primary aims of this study are to assess, whether supplementation of vitamin D3 increases 1) volumetric bone mineral density measured by high-resolution peripheral quantitative computed tomography (HR-pQCT); 2) bone strength assessed by finite element analysis, and 3) areal bone mineral density by dual X-ray absorptiometry (DXA)...
February 19, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29471104/cellular-senescence-as-a-therapeutic-target-to-improve-renal-transplantation-outcome
#12
REVIEW
Hester van Willigenburg, Peter L J de Keizer, Ron W F de Bruin
Kidney transplants from aged donors are more vulnerable to ischemic injury, suffer more from delayed graft function and have a lower graft survival compared to kidneys from younger donors. On a cellular level, aging results in an increase in cells that are in a permanent cell cycle arrest, termed senescence, which secrete a range of pro-inflammatory cytokines and growth factors. Consequently, these senescent cells negatively influence the local milieu by causing inflammaging, and by reducing the regenerative capacity of the kidney...
February 19, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29471067/the-smell-of-renal-protection-against-chronic-kidney-disease-hydrogen-sulfide-offers-a-potential-stinky-remedy
#13
REVIEW
George J Dugbartey
Chronic kidney disease (CKD) is a common global health challenge characterized by irreversible pathological processes that reduce kidney function and culminates in development of end-stage renal disease. It is associated with increased morbidity and mortality in addition to increased caregiver burden and higher financial cost. A central player in CKD pathogenesis and progression is renal hypoxia. Renal hypoxia stimulates induction of oxidative and endoplasmic reticulum stress, inflammation and tubulointerstitial fibrosis, which in turn, promote cellular susceptibility and further aggravate hypoxia, thus forming a pathological vicious cycle in CKD progression...
October 19, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29470854/the-cost-effectiveness-of-screening-in-the-community-to-reduce-osteoporotic-fractures-in-older-women-in-the-uk-economic-evaluation-of-the-scoop-study
#14
David A Turner, Rebekah Fong Soe Khioe, Lee Shepstone, Elizabeth Lenaghan, Cyrus Cooper, Neil Gittoes, Nicholas C Harvey, Richard Holland, Amanda Howe, Eugene McCloskey, Terence W O'Neill, David Torgerson, Richard Fordham
The SCOOP study was a two-arm randomized controlled trial conducted in the UK in 12,483 eligible women aged 70 to 85 years. It compared a screening program using the FRAX® risk assessment tool in addition to bone mineral density (BMD) measures versus usual management. The SCOOP study found a reduction in the incidence of hip fractures in the screening arm, but there was no evidence of a reduction in the incidence of all osteoporosis-related fractures. To make decisions about whether to implement any screening program, we should also consider whether the program is likely to be a good use of health care resources, ie, is it cost-effective? The cost per gained quality adjusted life year of screening for fracture risk has not previously been demonstrated in an economic evaluation alongside a clinical trial...
February 22, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29470739/the-association-between-osteoarthritis-and-sleep-duration-in-koreans-a-nationwide-cross-sectional-observational-study
#15
Jae Hyun Jung, Hongdeok Seok, Sung Jae Choi, Junwoo Bae, Sang Hoon Lee, Moo Hwa Lee, Jae-Hoon Kim, Gwan Gyu Song
Osteoarthritis (OA) causes chronic pain, physical disability, and mental health deterioration and reduces the quality of life of patients. Sleep is an important factor in the recovery, and adequate sleep is important for quality of life. Several features of patients with OA can affect sleep time, and sleep also affects OA. We investigated the relationship between OA and sleep duration. Data for 2010-2012 were collected from the Korea National Health and Nutrition Examination Survey. We included 11,540 participants (4915 men and 6625 women)...
February 22, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29470731/sacral-neuromodulation-versus-personalized-conservative-treatment-in-patients-with-idiopathic-slow-transit-constipation-study-protocol-of-the-no-2-trial-a-multicenter-open-label-randomized-controlled-trial-and-cost-effectiveness-analysis
#16
S C M Heemskerk, A H Rotteveel, M A Benninga, C I M Baeten, A A M Masclee, J Melenhorst, S M J van Kuijk, C D Dirksen, S O Breukink
PURPOSE: The evidence regarding the (cost-)effectiveness of sacral neuromodulation (SNM) in patients with therapy-resistant idiopathic slow-transit constipation is of suboptimal quality. The Dutch Ministry of Health, Welfare and Sports has granted conditional reimbursement for SNM treatment. The objective is to assess the effectiveness, cost-effectiveness, and budget impact of SNM compared to personalized conservative treatment (PCT) in patients with idiopathic slow-transit constipation refractory to conservative treatment...
February 22, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29470713/health-related-quality-of-life-in-patients-undergoing-cervico-thoracic-osteotomies-for-fixed-cervico-thoracic-kyphosis-in-patients-with-ankylosing-spondylitis
#17
Silviu Sabou, Hossein Mehdian, Dritan Pasku, Luca Boriani, Nasir A Quraishi
PURPOSE: Ankylosing spondylitis (AS) can result in severe cervico-thoracic kyphotic deformity (CTKD). Few studies have addressed the relationship between cervico-thoracic osteotomies in AS and health-related quality of life scores. The aim of this study is to evaluate the impact of cervico-thoracic osteotomy (CTO) on improving quality of life for patients with fixed CTKD. METHODS: A database of all patients who underwent a CTO for CTKD in patients with AS was created...
February 22, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29470704/relationship-between-sleep-and-exercise-as-colorectal-cancer-survivors-transition-off-treatment
#18
Theresa Coles, Antonia V Bennett, Xianming Tan, Claudio L Battaglini, Hanna K Sanoff, Ethan Basch, Roxanne E Jensen, Bryce B Reeve
PURPOSE: The primary objective of this study was to evaluate the relationship between exercise and sleep disturbance in a sample of individuals diagnosed with stage I, II, and III colorectal cancer (CRC) as patients transitioned off first-line treatment. We also sought to identify heterogeneity in the relationship between sleep disturbance and exercise. METHODS: Data were obtained from the MY-Health study, a community-based observational study of adults diagnosed with cancer...
February 22, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29470573/factors-associated-with-health-related-quality-of-life-in-medically-and-surgically-treated-patients-with-glaucoma
#19
Cheryl L Khanna, David A Leske, Jonathan M Holmes
Importance: Health-related quality of life (HRQOL) is often reduced with glaucoma, but associated factors are poorly understood. Objective: To determine factors associated with reduced HRQOL in medically and surgically treated patients with glaucoma. Design, Setting, and Participants: Prospective cohort study at a tertiary referral glaucoma practice, with 160 consecutive, prospectively enrolled medically or surgically treated adult patients with glaucoma...
February 22, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29470565/sociodemographic-medical-and-psychosocial-factors-associated-with-supportive-care-needs-in-adults-diagnosed-with-uveal-melanoma
#20
Timothy J Williamson, Alexandra Jorge-Miller, Tara A McCannel, Tammy M Beran, Annette L Stanton
Importance: Understanding supportive care needs in patients with cancer is important for developing approaches that enhance quality of life and promote satisfaction with care. Objective: To characterize the nature and frequency of sociodemographic, medical, and psychosocial factors associated with unmet needs in patients with uveal melanoma 1 week and 3 months after diagnosis. Design, Setting, and Participants: This 3-month, prospective, longitudinal survey study was conducted at a university-based ophthalmology practice from June 1, 2007, to July 1, 2011...
February 22, 2018: JAMA Ophthalmology
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