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Fever and antipyretic use in children

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https://www.readbyqxmd.com/read/28097438/attitudes-towards-fever-amongst-uk-paediatric-intensive-care-staff
#1
Thomas Brick, Rachel S Agbeko, Patrick Davies, Peter J Davis, Akash Deep, Peter-Marc Fortune, David P Inwald, Amy Jones, Richard Levin, Kevin P Morris, John Pappachan, Samiran Ray, Shane M Tibby, Lyvonne N Tume, Mark J Peters
: The role played by fever in the outcome of critical illness in children is unclear. This survey of medical and nursing staff in 35 paediatric intensive care units and transport teams in the United Kingdom and Ireland established attitudes towards the management of children with fever. Four hundred sixty-two medical and nursing staff responded to a web-based survey request. Respondents answered eight questions regarding thresholds for temperature control in usual clinical practice, indications for paracetamol use, and readiness to participate in a clinical trial of permissive temperature control...
January 18, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28063133/a-clinical-and-safety-review-of-paracetamol-and-ibuprofen-in-children
#2
REVIEW
Dipak J Kanabar
The antipyretic analgesics, paracetamol, and non-steroidal anti-inflammatory agents NSAIDs are one of the most widely used classes of medications in children. The aim of this review is to determine if there are any clinically relevant differences in safety between ibuprofen and paracetamol that may recommend one agent over the other in the management of fever and discomfort in children older than 3 months of age.
February 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/27958254/parental-beliefs-and-practices-regarding-childhood-fever-in-turkish-primary-care
#3
E Yavuz, E Yayla, S E Cebeci, E Kırımlı, R Ş Gümüştakım, L Çakır, S Doğan
BACKGROUND: Fever is a very common problem in pediatric age and is one of the most common reasons parents seek medical attention. We aimed to investigate beliefs, habits, and concerns of Turkish parents regarding their children's fever. MATERIALS AND METHODS: We performed a cross-sectional survey which was conducted as face-to-face interviews by family physicians from April to June 2014 in family healthcare centers in nine different cities in Turkey. Parents with a child with fever aged between 0 and 14 years were interviewed...
January 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/27825318/prevalence-of-malaria-typhoid-toxoplasmosis-and-rubella-among-febrile-children-in-cameroon
#4
Olivia A Achonduh-Atijegbe, Kenji O Mfuh, Aristid H E Mbange, Jean P Chedjou, Diane W Taylor, Vivek R Nerurkar, Wilfred F Mbacham, Rose Leke
BACKGROUND: The current roll-out of rapid diagnostic tests (RDTs) in many endemic countries has resulted in the reporting of fewer cases of malaria-attributed illnesses. However, lack of knowledge of the prevalence of other febrile illnesses and affordable diagnostic tests means that febrile patients are not managed optimally. This study assessed the prevalence of commonly treatable or preventable febrile illnesses in children between 6 months and 15 years using rapid diagnostic tests at the point-of-care...
November 8, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27810155/2016-update-of-the-italian-pediatric-society-guidelines-for-management-of-fever-in-children
#5
Elena Chiappini, Elisabetta Venturini, Giulia Remaschi, Nicola Principi, Riccardo Longhi, Pier-Angelo Tovo, Paolo Becherucci, Francesca Bonsignori, Susanna Esposito, Filippo Festini, Luisa Galli, Bice Lucchesi, Alessandro Mugelli, Gian Luigi Marseglia, Maurizio de Martino
OBJECTIVE: To review new scientific evidence to update the Italian guidelines for managing fever in children as drafted by the panel of the Italian Pediatric Society. STUDY DESIGN: Relevant publications in English and Italian were identified through search of MEDLINE and the Cochrane Database of Systematic Reviews from May 2012 to November 2015. RESULTS: Previous recommendations are substantially reaffirmed. Antipyretics should be administered with the purpose to control the child's discomfort...
January 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/27798399/parental-approach-to-the-prevention-and-management-of-fever-and-pain-following-childhood-immunizations-a-survey-study
#6
Ezzeldin Saleh, Geeta K Swamy, M Anthony Moody, Emmanuel B Walter
Antipyretic analgesics are commonly used to prevent and treat adverse events following immunizations. Current practice discourages routine use due to possible blunting of vaccine immune responses. We surveyed 150 parents/caregivers of recently vaccinated 6- and 15-month-old children to determine the prevalence of and beliefs regarding antipyretic analgesics use around vaccinations. 11% used them prophylactically, before vaccination. Use in the first 48 hours after vaccination was 64%, primarily to prevent and/or treat fever and pain...
October 23, 2016: Clinical Pediatrics
https://www.readbyqxmd.com/read/27781110/why-fever-phobia-is-still-common
#7
Suzan Gunduz, Esma Usak, Tulin Koksal, Metin Canbal
BACKGROUND: Fever is a reliable sign of illness, but it also evokes fear and anxiety. It is not the fever itself but the fear of possible complications and accompanying symptoms that is important for pediatricians and parents. OBJECTIVES: We aimed to investigate maternal understanding of fever, its potential consequences, and impacts on the treatment of children. PATIENTS AND METHODS: A questionnaire was use to explore the attitudes, knowledge, and practices of mothers of 861 children brought to four medical centers in different regions of Turkey in 2012, with fever being the chief complaint...
August 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/27642433/-asymptomatic-parasitemia-in-under-five-school-age-children-and-households-self-medication-lubumbashi-democratic-republic-of-congo
#8
Sompwe Eric Mukomena, Cilundika Mulenga Philipe, Mashinda Kulimba Désiré, Lutumba Tshindele Pascal, Mapatano Mala Ali, Luboya Numbi Oscar
INTRODUCTION: Long neglected, asymptomatic malaria is currently recognized as a potential threat and obstacle to malaria control. In DR Congo, the prevalence of this parasite is poorly documented. This study aims to determine the prevalence of asymptomatic parasitaemia in children less than 5 years of age as well as in those aged over five years for what concerns ongoing mass control interventions (LLINs). METHODS: This is a cross-sectional study conducted among school age children, children less than 5 years of age living in the household of Lubumbashi...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27458064/ibuprofen-in-paediatrics-pharmacology-prescribing-and-controversies
#9
Camilla Moriarty, Will Carroll
Ibuprofen, a propionic acid derivative, is a non-steroidal anti-inflammatory drug. The oral formulation is widely used in paediatric practice and after paracetamol it is one of the most common drugs prescribed for children in hospital. The treatment of fever with antipyretics such as ibuprofen is controversial as fever is the normal response of the body to infection and unless the child becomes distressed or symptomatic, fever alone should not be routinely treated. Combined treatment with paracetamol and ibuprofen is commonly undertaken but almost certainly is not helpful...
December 2016: Archives of Disease in Childhood. Education and Practice Edition
https://www.readbyqxmd.com/read/27401677/parental-knowledge-attitudes-and-beliefs-regarding-fever-in-children-an-interview-study
#10
Maria Kelly, Laura J Sahm, Frances Shiely, Ronan O'Sullivan, Aoife McGillicuddy, Suzanne McCarthy
BACKGROUND: Fever is one of the most common childhood symptoms. It causes significant worry and concern for parents. Every year there are numerous cases of over- and under-dosing with antipyretics. Caregivers seek reassurance from a variety of sources including healthcare practitioners. The aim of this study was to describe parental knowledge, attitudes and beliefs regarding management of childhood fever in children aged 5 years and under. METHOD: Semi-structured interviews were conducted with 23 parents at six ante-natal clinics in the south west of Ireland during March and April 2015...
July 11, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27315082/drivers-for-inappropriate-fever-management-in-children-a-systematic-review
#11
M Kelly, S McCarthy, R O'Sullivan, F Shiely, P Larkin, M Brenner, L J Sahm
Background Fever is one of the most common childhood symptoms and accounts for numerous consultations with healthcare practitioners. It causes much anxiety amongst parents as many struggle with managing a feverish child and find it difficult to assess fever severity. Over- and under-dosing of antipyretics has been reported. Aim of the review The aim of this review was to synthesise qualitative and quantitative evidence on the knowledge, attitudes and beliefs of parents regarding fever and febrile illness in children...
August 2016: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/27118212/pharmacokinetic-properties-of-intramuscular-versus-oral-syrup-paracetamol-in-plasmodium-falciparum-malaria
#12
RANDOMIZED CONTROLLED TRIAL
Thanaporn Wattanakul, Pramote Teerapong, Katherine Plewes, Paul N Newton, Wirongrong Chierakul, Kamolrat Silamut, Kesinee Chotivanich, Ronnatrai Ruengweerayut, Nicholas J White, Arjen M Dondorp, Joel Tarning
BACKGROUND: Fever is an inherent symptom of malaria in both adults and children. Paracetamol (acetaminophen) is the recommended antipyretic as it is inexpensive, widely available and has a good safety profile, but patients may not be able to take the oral drug reliably. A comparison between the pharmacokinetics of oral syrup and intramuscular paracetamol given to patients with acute falciparum malaria and high body temperature was performed. METHODS: A randomized, open-label, two-treatment, crossover, pharmacokinetic study of paracetamol dosed orally and intramuscularly was conducted...
April 27, 2016: Malaria Journal
https://www.readbyqxmd.com/read/26920747/acetaminophen-administration-in-pediatric-age-an-observational-prospective-cross-sectional-study
#13
Riccardo Lubrano, Sara Paoli, Marco Bonci, Luigi Di Ruzza, Corrado Cecchetti, Raffaele Falsaperla, Piero Pavone, Nassim Matin, Giovanna Vitaliti, Isotta Gentile
BACKGROUND: Parents often do not consider fever as an important physiological response and mechanism of defense against infections that leads to inappropriate use of antipyretics and potentially dangerous side effects. This study is designed to evaluate the appropriateness of antipyretics dosages generally administered to children with fever, and to identify factors that may influence dosage accuracy. RESULTS: In this cross-sectional study we analyzed the clinical records of 1397 children aged >1 month and < 16 years, requiring a primary care (ambulatory) outpatient visit due to fever...
February 26, 2016: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/26539405/pilot-study-of-the-use-of-yin-qiao-san-in-children-with-conventional-antipyretic-hypersensitivity
#14
Woei Kang Liew, Wenyin Loh, Wen Chin Chiang, Anne Goh, Oh Moh Chay, Mona Iancovici Kidon
BACKGROUND: Children with a diagnosis of cross-reactive hypersensitivity to both paracetamol and nonsteroidal anti-inflammatory drugs are limited in their choice of antipyretics. OBJECTIVE: The aim of this pilot study is to evaluate the feasibility of using a Chinese proprietary medicine, Yin Qiao San (YQS), for fever relief. METHODS: A single centre, open label, prospective clinical trial exploring the tolerability and feasibility of using YQS for fever relief in children who are unable to use conventional antipyretic medications...
October 2015: Asia Pacific Allergy
https://www.readbyqxmd.com/read/26518691/recent-advances-in-pediatric-use-of-oral-paracetamol-in-fever-and-pain-management
#15
Maurizio de Martino, Alberto Chiarugi
Paracetamol is a common analgesic and antipyretic drug for management of fever and mild-to-moderate pain in infants and children, and it is considered as first-line therapy for the treatment of both according to international guidelines and recommendations. The mechanism of action of paracetamol is complex and multifactorial, and several aspects of the pharmacology impact its clinical use, especially in the selection of the correct analgesic and antipyretic dose. A systematic literature search was performed by following procedures for transparent reporting of systematic reviews and meta-analyses...
December 2015: Pain and Therapy
https://www.readbyqxmd.com/read/26514056/managing-the-child-with-a-fever
#16
REVIEW
Rosie Hague
Most illnesses associated with fever are self-limiting and children recover with no specific treatment. However, fever can also be the presenting feature of serious illness, which may be life threatening if not diagnosed and treated appropriately. It is important to establish whether the temperature has been measured and, if so, how. The height of the temperature should be recorded, and always enquire what device has been used, as a reading from a forehead thermometer may not be accurate. While many families will use a thermometer the impression of the child being hot to touch without formal measurement should still be taken seriously...
July 2015: Practitioner
https://www.readbyqxmd.com/read/26387247/management-of-acute-childhood-fevers
#17
Polly Teuten, Siba Prosad Paul, Paul Anthony Heaton
Feverish illnesses commonly affect children and are the second most frequent reason for a child to be admitted to hospital. Most cases are viral in origin, usually with a good prognosis. Fever can be caused by severe and rapidly progressive illness which needs urgent referral to hospital for potentially life-saving treatment, and community practitioners must be able to identify such cases showing 'red flag'features. The fear of serious disease among parents and carers may result in 'fever phobia' leading to minor illnesses being managed inappropriately...
July 2015: Journal of Family Health
https://www.readbyqxmd.com/read/25941128/-effectiveness-of-pidotimod-in-combination-with-bacterial-lysates-in-the-treatment-of-the-pfapa-periodic-fever-aphthous-stomatitis-pharyngitis-and-cervical-adenitis-syndrome
#18
A Buongiorno, N Pierossi
AIM: PFAPA (periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis) syndrome is the most common autoinflammatory syndrome in pediatrics, accepted as an hyperimmune condition. Pidotimod is a molecule with immunomodulatory activity on both innate and adaptive immune responses; it also has the capacity to modulate the function of the respiratory epithelial cells through the activation of a NK-KB pathway which would involve the host-virus interaction. Moreover, the proven beneficial effect of Pidotimod in enhancing the immune response during vaccination, and its benefits in the prevention of respiratory tract infections, should be noted...
June 2015: Minerva Pediatrica
https://www.readbyqxmd.com/read/25897106/intentional-and-accidental-paracetamol-poisoning-in-childhood-a-retrospective-analysis
#19
Katarzyna Kominek, Agnieszka Pawłowska-Kamieniak, Agnieszka Mroczkowska-Juchkiewicz, Paulina Krawiec, Elżbieta Pac-Kożuchowska
INTRODUCTION: Paracetamol is one of the most commonly used analgesics and antipyretics available without limits as preparations of the OTC group (over the counter drugs). Overdose and poisoning with this drug always brings about the risk of acute hepatic failure. The objective of the study was a retrospective evaluation of patients hospitalized in the Paediatric Clinic during the period 2004-2012 due to poisoning with paracetamol. MATERIAL AND METHODS: The analysis covered 44 patients hospitalized in the Paediatric Clinic during 2004-2012 due to poisoning with paracetamol...
2015: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/25882057/kawasaki-disease-an-evolving-paradigm
#20
REVIEW
Antonio Greco, Armando De Virgilio, Maria Ida Rizzo, Mario Tombolini, Andrea Gallo, Massimo Fusconi, Giovanni Ruoppolo, Giulio Pagliuca, Salvatore Martellucci, Marco de Vincentiis
Kawasaki disease (KD) is a self-limited childhood systemic vasculitis that exhibits a specific predilection for the coronary arteries. KD predominantly affects young children between the ages of 6months and 4years. Incidence rates in Asians are up to 20 times higher than Caucasians. The aetiology of KD is not known. One reasonable open hypothesis is that KD is caused by an infectious agent that produces an autoimmune disease only in genetically predisposed individuals. The typical presentation of KD is a young child who has exhibited a high swinging fever for five or more days that persists despite antibiotic and/or antipyretic treatment...
August 2015: Autoimmunity Reviews
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