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https://www.readbyqxmd.com/read/29232497/evaluation-of-olfaction-and-taste-function-in-type-2-diabetic-patients-with-and-without-peripheral-neuropathy
#1
Semih Yazla, Süay Özmen, Sinem Kıyıcı, Demet Yıldız, Mehmet Haksever, Sündüz Gencay
AIMS: Olfaction and gustation in patients with diabetes mellitus (DM) have great significance on quality of life and their impairment may result in possible hazards. A limited number of studies have been performed to determine the alteration of both gustatory and olfactory function in type 2 diabetic patients with diabetic peripheral neuropathy (DPN). The aim of this study was to determine whether type 2 diabetic patients, with and without DPN, exhibit major olfactory and gustatory dysfunction using validated and dependable techniques...
December 12, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29214617/gehs-neurophysiological-classification-system-for-patients-with-neuropathy-of-the-ulnar-nerve-at-the-elbow
#2
David G Greathouse, Greg Ernst, John S Halle, Scott W Shaffer
BACKGROUND: Neuropathy of the ulnar nerve at the elbow is one of a number of muscle-related and nerve-related disorders that affect people performing intensive work with their hands and upper extremities, and is the second most prevalent peripheral nerve mononeuropathy. There are several classification systems currently being used by the medical community for patients with neuropathy of the ulnar nerve at the elbow. However, few of these classification systems include the clinical electrophysiologic parameters nerve conduction (NCS) and electromyographic (EMG) studies...
October 2017: U.S. Army Medical Department Journal
https://www.readbyqxmd.com/read/28844760/template-operated-mup-analysis-is-not-accurate-in-the-diagnosis-of-myopathic-or-neuropathic-changes-in-the-diaphragm
#3
Lea Leonardis, Simon Podnar
OBJECTIVES: The aim of this study was to evaluate the quantitative motor unit potential (MUP) analysis in the diagnosis of myopathy and neuropathy of the diaphragm. METHODS: Diaphragm template-operated quantitative EMG were performed in 30 patients with myotonic dystrophy type 1 (DM1), 17 with myotonic dystrophy type 2 (DM2) and 40 with amyotrophic lateral sclerosis (ALS). RESULTS: Low MUP amplitude precluded MUP analysis in 21% of DM1 patients...
August 24, 2017: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/28838824/phlebectasia-in-a-finger-in-a-case-of-microscopic-polyangiitis-with-peripheral-polyneuropathy
#4
Jorge Julio Badía Flores, Federico G Arévalo Martínez
The patient was a 56-year-old man with microscopic polyangiitis and symmetrical peripheral polyneuropathy of the extremities who was positive for p-ANCA, EMG pattern of mononeuritis multiplex and skin biopsy showing the presence of nonspecific vasculitis. He had phlebectasia with plethora and tortuous vessels on dorsum of the fingers on both hands, paresis and hypoesthesia of fingers and toes with functional limitations. The administration of prednisone, azathioprine and a cyclophosphamide pulse achieved rapid improvement in the general symptoms, but the changes in the neuropathy occurred very slowly...
August 22, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28828220/a-waves-increase-the-risk-of-developing-neuropathy
#5
Iva Srotova, Eva Vlckova, Ladislav Dusek, Josef Bednarik
INTRODUCTION: A-waves, which are observed following the M-wave during motor nerve conduction studies (NCS), are late responses that are frequently found in many types of neurogenic disorders. However, A-waves are also common in healthy individuals, where their significance remains unclear. The aim of this study was to examine whether the occurrence of A-waves does in fact represent an increased risk for the future development of changes upon NCS or needle electromyography (EMG) in the corresponding nerve...
August 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28798722/autonomic-neuropathy-and-albuminocytologic-dissociation-in-cerebrospinal-fluid-as-the-presenting-features-of-primary-amyloidosis-a-case-report
#6
Jingjing Li, Yi Li, Hongbing Chen, Shihui Xing, Huiyu Feng, Dawei Liu, Dilong Wang, Jinsheng Zeng, Yuhua Fan
OBJECTIVE: Primary amyloidosis is a disease with a poor prognosis and multi-organ involvement. Here, we report the clinical and pathological features of a patient with primary amyloidosis featuring autonomic neuropathy as the initial symptom and albuminocytologic dissociation in the cerebrospinal fluid (CSF). METHODS: The patient was a 60-year-old Chinese male with numbness, orthostatic hypotension, and gastrointestinal symptoms. For diagnosis, we performed an electromyogram (EMG), lumbar puncture, Bence Jones protein urine test, serum electrophoresis blood test, sural nerve and rectal membrane biopsies, transthyretin (TTR) gene sequencing, and bone marrow puncture...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28593000/ultrasound-and-emg-ncv-study-electromyography-and-nerve-conduction-velocity-correlation-in-diagnosis-of-nerve-pathologies
#7
REVIEW
Shilpa Domkundwar, Gayatri Autkar, S V Khadilkar, Mayur Virarkar
PURPOSE: Nerve disorders are commonly encountered in clinical practice. Ultrasonography (USG) is a useful modality in the evaluation of most of the peripheral and superficial pathologies amenable to penetration by ultrasound. The primary objective is to study the USG findings of various peripheral nerve pathologies and to correlate them with electrophysiological (EMG-NCV) findings. METHOD: 42 patients referred with suspicion of peripheral nervous system affection were evaluated with USG along with EMG-NCV...
June 2017: Journal of Ultrasound
https://www.readbyqxmd.com/read/28389398/-numb-leg-in-a-crossfit-athlete-a-case-presentation
#8
Stephan Esser, Mckennan Thurston, Krishna Nalluri, Aurelio Muzaurieta
Participation in CrossFit athletics and Olympic-style lifting by the general populace has rapidly increased in the last 10 years. Such athletic engagement poses unique, inadequately defined risks to the participant. We describe the case of a 36-year-old man who presented to an outpatient sports medicine clinic with 6 weeks of numbness and tingling in the lateral right proximal thigh. After thorough examination and electromyographic testing, he was found to have a lateral femoral cutaneous neuropathy caused by performing supine gluteal bridges with a weighted barbell resting across his anterior thighs...
August 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28249248/neuroprotective-effects-of-octreotide-on-diabetic-neuropathy-in-rats
#9
Volkan Solmaz, Bilge Piri Çınar, Gürkan Yiğittürk, Hatice Köse Özlece, Hüseyin Avni Eroglu, Aslan Tekatas, Oytun Erbaş, Dilek Taşkıran
The purpose of the present study is to investigate the possible healing effects of octreotide (OCT) on motor performance, electrophysiological and histopathological findings of diabetic neuropathy in a rat model of diabetes mellitus (DM). To induce diabetes, rats were administered a single dose (60mg/kg) of streptozotocin (STZ). Diabetic rats were treated either with saline (1ml/kg/day, n=7) or OCT (0.1mg/kg/day, n=7) for four weeks. Seven rats served as control group and received no treatment. At the end of the study, electromyography (EMG), gross motor function (inclined plate test), general histology and the perineural thickness of sciatic nerve were evaluated...
May 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28202889/treatment-of-transthyretin-familial-amyloid-polyneuropathy-with-tafamidis-a-case-report
#10
Yoshimichi Miyazaki
INTRODUCTION: Familial amyloid polyneuropathy (FAP) is a rare hereditary disorder caused by mutations in the transthyretin (TTR) gene. Tafamidis is a TTR stabilizer able to prevent TTR tetramer dissociation, and several studies have demonstrated its safety and efficacy at slowing the progression of neuropathy in FAP caused by the TTR Val30Met mutation. However, nerve conduction study (NCS) and electromyography (EMG) results have yet to be reported in relation to FAP progression during tafamidis therapy...
2017: Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
https://www.readbyqxmd.com/read/27881053/oxytocin-provides-protection-against-diabetic-polyneuropathy-in-rats
#11
Oytun Erbas, Dilek Taşkıran, Fatih Oltulu, Altuğ Yavaşoğlu, Saylav Bora, Okan Bilge, Bilge Piri Çınar, Gönül Peker
PURPOSE: The aim of the present study is to investigate the protective effects of oxytocin (OT) on diabetic neuropathy (DNP) in rats. MATERIALS AND METHODS: Eighteen rats were used to induce diabetes using single dose streptozotocin (STZ, 60 mg/kg). Diabetic DNP was verified by electromyography (EMG) and motor function test on 21st day following STZ injection. Six rats served as naïve control group and received no drug (n = 6). Following EMG, diabetic rats were randomly divided into three groups and administered with either 1 ml/kg saline or 80 μg/kg OT or 160 μg/kg OT intraperitoneally for four weeks...
January 2017: Neurological Research
https://www.readbyqxmd.com/read/27820766/neurologic-evaluations-of-patients-exposed-to-the-world-trade-center-disaster
#12
Mark M Stecker, Huiying Yu, Renee Barlev, Michael Marmor, Marc Wilkenfeld
OBJECTIVE: The aim of this study was to describe the clinical phenotype of a limited group of responders and survivors of the World Trade Center (WTC) disaster who were referred for the evaluation of neuropathic symptoms. METHODS: Sixteen patients with WTC exposure were referred to a neurologist for evaluation. All had a neurologic examination. Most had electromyogram and nerve conduction testing/nerve conduction studies as well as appropriate imaging and blood tests...
November 2016: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27789344/behavioral-and-electromyographic-assessment-of-oxaliplatin-induced-motor-dysfunctions-evidence-for-a-therapeutic-effect-of-allopregnanolone
#13
O Taleb, F Bouzobra, H Tekin-Pala, L Meyer, A G Mensah-Nyagan, C Patte-Mensah
The antineoplastic oxaliplatin (OXAL) is pivotal for metastatic cancer treatments. However, OXAL evokes sensory and motor side-effects including pain, muscle weakness, motor nerve fiber dysfunctions/neuropathies that significantly impact patients' lives. Therefore, preclinical investigations are struggling to characterize effective analgesics against OXAL-induced painful/sensory symptoms but surprisingly, OXAL-evoked motor dysfunctions received little attention although these neurological symptoms are also disabling for patients...
October 24, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27685694/utilization-and-yield-of-nerve-conduction-studies-and-electromyography-in-older-adults
#14
S Mello, O O'Toole, B McNamara
Older adults are at increased risk of both central and peripheral neurological disorders. Impaired nerve and muscle deficits contribute to morbidity and reduced quality of life. Our aim was to define the utilization and yield of nerve conduction studies (NCS) and electromyography (EMG) in older adults. We reviewed NCS and EMG records for all patients older than age 65 in the year 2012. Of 1,530 NCS and EMGs performed, 352 (23%) were in patients older than 65 (mean age 73.7, 52% male). 288 (83.7%) of NCS were abnormal as were 102 (71...
February 19, 2016: Irish Medical Journal
https://www.readbyqxmd.com/read/27668106/atypical-features-in-a-large-turkish-family-affected-with-friedreich-ataxia
#15
Semiha Kurt, Betul Cevik, Durdane Aksoy, E Irmak Sahbaz, Aslı Gundogdu Eken, A Nazli Basak
Here, we describe the clinical features of several members of the same family diagnosed with Friedreich ataxia (FRDA) and cerebral lesions, demyelinating neuropathy, and late-age onset without a significant cardiac involvement and presenting with similar symptoms, although genetic testing was negative for the GAA repeat expansion in one patient of the family. The GAA repeat expansion in the frataxin gene was shown in all of the family members except in a young female patient. MRI revealed arachnoid cysts in two patients; MRI was consistent with both cavum septum pellucidum-cavum vergae and nodular signal intensity increase in one patient...
2016: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/27530902/small-autonomic-and-large-fiber-neuropathy-in-parkinson-disease-and-parkinsonism
#16
Davi Farias de Araújo, Antônio Pinto de Melo Neto, Ítalo Sérgio Cavalcante Oliveira, Beatriz Soares Brito, Ineusi Teixeira de Araújo, Ingrid Sousa Barros, José Wellington Oliveira Lima, Wagner Goes Horta, Francisco de Assis Aquino Gondim
BACKGROUND: Recent studies have reported that peripheral neuropathy (PN) is common in patients with Parkinson's disease (PD) and raised the possibility that levodopa neurotoxicity is the main culprit. METHODS: We evaluated the presence of large & small (autonomic) fiber PN in 54 consecutive patients with PD or parkinsonism in a tertiary outpatient clinic from Brazil. Initial PN screening consisted of history/neurological exam and skin wrinkling test (SWT). In addition, we also performed Nerve conduction studies/Electromyography (NCS/EMG) in all patients with PN signs/symptoms and/or abnormal SWT...
August 17, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27422051/transthyretin-amyloid-neuropathy-has-earlier-neural-involvement-but-better-prognosis-than-primary-amyloid-counterpart-an-answer-to-the-paradox
#17
COMPARATIVE STUDY
Adam J Loavenbruck, Wolfgang Singer, Michelle L Mauermann, Paola Sandroni, P James B Dyck, Morie Gertz, Christopher J Klein, Phillip A Low
OBJECTIVE: To systematically compare transthyretin with primary amyloid neuropathy to define their natural history and the underlying mechanisms for differences in phenotype and natural history. METHODS: All patients with defined amyloid subtype and peripheral neuropathy who completed autonomic testing and electromyography at Mayo Clinic Rochester between 1993 and 2013 were included. Medical records were reviewed for time of onset of defined clinical features. The degree of autonomic impairment was quantified using the composite autonomic severity scale...
September 2016: Annals of Neurology
https://www.readbyqxmd.com/read/27386647/-effect-of-tanshinone-iia-in-preventing-and-treating-oxaliplatin-induced-peripheral-neuropathy
#18
RANDOMIZED CONTROLLED TRIAL
Kai Xu, Wei-ting Cheng, Zuo-wei Hu, Wang Shan
OBJECTIVE: To observe preventive and therapeutic effects of Tanshinone IIA (T II A) on oxaliplatin induced peripheral neuropathy (OlPN) and to explore its effects on the expression of calcitonin gene related peptide (CGRP) and never growth factor (NGF). METHODS: Totally 36 phase II - III patients with malignant tumor of digestive tract undergoing chemotherapy program with oxaliplatin, were equally assigned to the T II A group (using THA at 80 mg/day 1 day before oxaliplatin chemotherapy for 3 successive days) and the control group (using chemotherapy program with oxaliplatin alone) by segmented randomization...
May 2016: Chinese Journal of Integrated Traditional and Western Medicine
https://www.readbyqxmd.com/read/26874099/gehs-neurophysiological-classification-system-for-patients-with-carpal-tunnel-syndrome
#19
David G Greathouse, Greg Ernst, John S Halle, Scott W Shaffer
BACKGROUND: Median neuropathy at or distal to the wrist or carpal tunnel syndrome (CTS) is one of a number of muscle, tendon, and nerve-related disorders that affect people performing intensive work with their hands. Following a thorough history and physical examination, electrophysiological examination including both nerve conduction studies (NCS) and electromyography (EMG) testing may be performed and currently serve as the reference standard for the diagnosis of CTS. The EMG and NCS exams should identify the peripheral nerve, specific location in the nerve pathway, involvement of sensory and/or motor axons, and the presence of myelinopathy and/or axonopathy neuropathic process...
January 2016: U.S. Army Medical Department Journal
https://www.readbyqxmd.com/read/26795972/neuroprotective-effects-of-chronic-administration-of-levetiracetam-in-a-rat-model-of-diabetic-neuropathy
#20
Oytun Erbaş, Fatih Oltulu, Mustafa Yılmaz, Altuğ Yavaşoğlu, Dilek Taşkıran
OBJECTIVE: Diabetic neuropathy (DNP) is a frequent and serious complication of diabetes mellitus (DM) that leads to progressive and length-dependent loss of peripheral nerve axons. The purpose of the present study is to assess the neuroprotective effects of levetiracetam (LEV) on DNP in a streptozotocin (STZ)-induced DM model in rats. METHODS: Adult Sprague-Dawley rats were administered with STZ (60mg/kg) to induce diabetes. DNP was confirmed by electromyography (EMG) and motor function test on 21st day following STZ injection...
April 2016: Diabetes Research and Clinical Practice
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