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https://www.readbyqxmd.com/read/27881053/oxytocin-provides-protection-against-diabetic-polyneuropathy-in-rats
#1
Oytun Erbas, Dilek Taşkıran, Fatih Oltulu, Altuğ Yavaşoğlu, Saylav Bora, Okan Bilge, Bilge Piri Çınar, Gönül Peker
PURPOSE: The aim of the present study is to investigate the protective effects of oxytocin (OT) on diabetic neuropathy (DNP) in rats. MATERIALS AND METHODS: Eighteen rats were used to induce diabetes using single dose streptozotocin (STZ, 60 mg/kg). Diabetic DNP was verified by electromyography (EMG) and motor function test on 21st day following STZ injection. Six rats served as naïve control group and received no drug (n = 6). Following EMG, diabetic rats were randomly divided into three groups and administered with either 1 ml/kg saline or 80 μg/kg OT or 160 μg/kg OT intraperitoneally for four weeks...
November 24, 2016: Neurological Research
https://www.readbyqxmd.com/read/27820766/neurologic-evaluations-of-patients-exposed-to-the-world-trade-center-disaster
#2
Mark M Stecker, Huiying Yu, Renee Barlev, Michael Marmor, Marc Wilkenfeld
OBJECTIVE: The aim of this study was to describe the clinical phenotype of a limited group of responders and survivors of the World Trade Center (WTC) disaster who were referred for the evaluation of neuropathic symptoms. METHODS: Sixteen patients with WTC exposure were referred to a neurologist for evaluation. All had a neurologic examination. Most had electromyogram and nerve conduction testing/nerve conduction studies as well as appropriate imaging and blood tests...
November 2016: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27789344/behavioral-and-electromyographic-assessment-of-oxaliplatin-induced-motor-dysfunctions-evidence-for-a-therapeutic-effect-of-allopregnanolone
#3
Omar Taleb, Fateh Bouzobra, Hava Tekin-Pala, Laurence Meyer, Ayikoé, G Mensah-Nyagan, Christine Patte-Mensah
The antineoplastic oxaliplatin (OXAL) is pivotal for metastatic cancer treatments. However, OXAL evokes sensory and motor side-effects including pain, muscle weakness, motor nerve fiber dysfunctions/neuropathies that significantly impact patients' lives. Therefore, preclinical investigations are struggling to characterize effective analgesics against OXAL-induced painful/sensory symptoms but surprisingly, OXAL-evoked motor dysfunctions received little attention although these neurological symptoms are also disabling for patients...
October 24, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27685694/utilization-and-yield-of-nerve-conduction-studies-and-electromyography-in-older-adults
#4
S Mello, O O'Toole, B McNamara
Older adults are at increased risk of both central and peripheral neurological disorders. Impaired nerve and muscle deficits contribute to morbidity and reduced quality of life. Our aim was to define the utilization and yield of nerve conduction studies (NCS) and electromyography (EMG) in older adults. We reviewed NCS and EMG records for all patients older than age 65 in the year 2012. Of 1,530 NCS and EMGs performed, 352 (23%) were in patients older than 65 (mean age 73.7, 52% male). 288 (83.7%) of NCS were abnormal as were 102 (71...
2016: Irish Medical Journal
https://www.readbyqxmd.com/read/27668106/atypical-features-in-a-large-turkish-family-affected-with-friedreich-ataxia
#5
Semiha Kurt, Betul Cevik, Durdane Aksoy, E Irmak Sahbaz, Aslı Gundogdu Eken, A Nazli Basak
Here, we describe the clinical features of several members of the same family diagnosed with Friedreich ataxia (FRDA) and cerebral lesions, demyelinating neuropathy, and late-age onset without a significant cardiac involvement and presenting with similar symptoms, although genetic testing was negative for the GAA repeat expansion in one patient of the family. The GAA repeat expansion in the frataxin gene was shown in all of the family members except in a young female patient. MRI revealed arachnoid cysts in two patients; MRI was consistent with both cavum septum pellucidum-cavum vergae and nodular signal intensity increase in one patient...
2016: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/27530902/small-autonomic-and-large-fiber-neuropathy-in-parkinson-disease-and-parkinsonism
#6
Davi Farias de Araújo, Antônio Pinto de Melo Neto, Ítalo Sérgio Cavalcante Oliveira, Beatriz Soares Brito, Ineusi Teixeira de Araújo, Ingrid Sousa Barros, José Wellington Oliveira Lima, Wagner Goes Horta, Francisco de Assis Aquino Gondim
BACKGROUND: Recent studies have reported that peripheral neuropathy (PN) is common in patients with Parkinson's disease (PD) and raised the possibility that levodopa neurotoxicity is the main culprit. METHODS: We evaluated the presence of large & small (autonomic) fiber PN in 54 consecutive patients with PD or parkinsonism in a tertiary outpatient clinic from Brazil. Initial PN screening consisted of history/neurological exam and skin wrinkling test (SWT). In addition, we also performed Nerve conduction studies/Electromyography (NCS/EMG) in all patients with PN signs/symptoms and/or abnormal SWT...
2016: BMC Neurology
https://www.readbyqxmd.com/read/27422051/transthyretin-amyloid-neuropathy-has-earlier-neural-involvement-but-better-prognosis-than-primary-amyloid-counterpart-an-answer-to-the-paradox
#7
Adam J Loavenbruck, Wolfgang Singer, Michelle L Mauermann, Paola Sandroni, P James B Dyck, Morie Gertz, Christopher J Klein, Phillip A Low
OBJECTIVE: To systematically compare transthyretin with primary amyloid neuropathy to define their natural history and the underlying mechanisms for differences in phenotype and natural history. METHODS: All patients with defined amyloid subtype and peripheral neuropathy who completed autonomic testing and electromyography at Mayo Clinic Rochester between 1993 and 2013 were included. Medical records were reviewed for time of onset of defined clinical features. The degree of autonomic impairment was quantified using the composite autonomic severity scale...
September 2016: Annals of Neurology
https://www.readbyqxmd.com/read/27386647/-effect-of-tanshinone-iia-in-preventing-and-treating-oxaliplatin-induced-peripheral-neuropathy
#8
RANDOMIZED CONTROLLED TRIAL
Kai Xu, Wei-ting Cheng, Zuo-wei Hu, Wang Shan
OBJECTIVE: To observe preventive and therapeutic effects of Tanshinone IIA (T II A) on oxaliplatin induced peripheral neuropathy (OlPN) and to explore its effects on the expression of calcitonin gene related peptide (CGRP) and never growth factor (NGF). METHODS: Totally 36 phase II - III patients with malignant tumor of digestive tract undergoing chemotherapy program with oxaliplatin, were equally assigned to the T II A group (using THA at 80 mg/day 1 day before oxaliplatin chemotherapy for 3 successive days) and the control group (using chemotherapy program with oxaliplatin alone) by segmented randomization...
May 2016: Chinese Journal of Integrated Traditional and Western Medicine
https://www.readbyqxmd.com/read/26874099/gehs-neurophysiological-classification-system-for-patients-with-carpal-tunnel-syndrome
#9
David G Greathouse, Greg Ernst, John S Halle, Scott W Shaffer
BACKGROUND: Median neuropathy at or distal to the wrist or carpal tunnel syndrome (CTS) is one of a number of muscle, tendon, and nerve-related disorders that affect people performing intensive work with their hands. Following a thorough history and physical examination, electrophysiological examination including both nerve conduction studies (NCS) and electromyography (EMG) testing may be performed and currently serve as the reference standard for the diagnosis of CTS. The EMG and NCS exams should identify the peripheral nerve, specific location in the nerve pathway, involvement of sensory and/or motor axons, and the presence of myelinopathy and/or axonopathy neuropathic process...
January 2016: U.S. Army Medical Department Journal
https://www.readbyqxmd.com/read/26795972/neuroprotective-effects-of-chronic-administration-of-levetiracetam-in-a-rat-model-of-diabetic-neuropathy
#10
Oytun Erbaş, Fatih Oltulu, Mustafa Yılmaz, Altuğ Yavaşoğlu, Dilek Taşkıran
OBJECTIVE: Diabetic neuropathy (DNP) is a frequent and serious complication of diabetes mellitus (DM) that leads to progressive and length-dependent loss of peripheral nerve axons. The purpose of the present study is to assess the neuroprotective effects of levetiracetam (LEV) on DNP in a streptozotocin (STZ)-induced DM model in rats. METHODS: Adult Sprague-Dawley rats were administered with STZ (60mg/kg) to induce diabetes. DNP was confirmed by electromyography (EMG) and motor function test on 21st day following STZ injection...
April 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/26684759/the-diagnostic-value-of-neuropathy-symptom-and-change-score-neuropathy-impairment-score-and-michigan-neuropathy-screening-instrument-for-diabetic-peripheral-neuropathy
#11
Qian Xiong, Bing Lu, Hongying Ye, Xia Wu, Tiansong Zhang, Yiming Li
AIMS: This study aims to evaluate the diagnostic capabilities of neuropathy symptom and change (NSC) score, neuropathy impairment score (NIS) and Michigan neuropathy screening instrument (MNSI) in diagnosing diabetic peripheral neuropathy (DPN). METHODS: A total of 131 patients with type II diabetes received NSC, NIS and MNSI scoring systems. Electromyography/nerve conduction velocity (EMG/NCV) test was taken as gold standard. Correlations between EMG/NCV test and the 3 scorings, and their sensitivity, specificity, positive and negative predictive values, accuracy and kappa (x03BA;) value were analyzed...
2015: European Neurology
https://www.readbyqxmd.com/read/26544817/pudendal-neuropathy-alone-results-in-urge-incontinence-rather-than-in-complete-fecal-incontinence
#12
COMPARATIVE STUDY
Maxime M van Meegdenburg, Erik Heineman, Paul M A Broens
BACKGROUND: Conscious external anal sphincter contraction is mediated by the pudendal nerve. Pudendal neuropathy is, therefore, believed to result in fecal incontinence. Until urge sensation is experienced, fecal continence is maintained by unconscious external anal sphincter contraction, which is regulated by the anal-external sphincter continence reflex. The innervation of unconscious contraction is yet unknown. OBJECTIVE: We aimed to determine whether unconscious contraction is mediated by the pudendal nerve and whether age influences unconscious contraction...
December 2015: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/26442534/the-role-of-wrist-magnetic-resonance-imaging-in-the-differential-diagnosis-of-the-carpal-tunnel-syndrome
#13
Mehmet Resid Onen, Ali Erhan Kayalar, Elif Nurbegum Ilbas, Recai Gokcan, Ilker Gulec, Sait Naderi
AIM: The carpal tunnel syndrome (CTS) is the commonest compressive neuropathy. Electromyography (EMG) is accepted as gold standard in diagnosis of CTS. However, pathologies and variations that are associated with a various findings may lead to failure. MATERIAL AND METHODS: Magnetic resonance Imaging (MRI) was applied to 69 wrists of 55 patients, who received a diagnosis of CTS by means of clinical and electrodiagnostic testing (EDT) during the years 2011 and 2013...
2015: Turkish Neurosurgery
https://www.readbyqxmd.com/read/25802819/practical-approach-to-electrodiagnosis-of-the-carpal-tunnel-syndrome-a-review
#14
REVIEW
Keivan Basiri, Bashar Katirji
Despite being the most common entrapment neuropathy and the most common reason for referral to the electromyography (EMG) laboratory, the diagnosis of carpal tunnel syndrome (CTS) continues to be challenging due to a large number of electrodiagnostic (EDX) tests available. We present a flowchart and propose a practical approach to the diagnosis of CTS using the available literature and the American Association of Neuromuscular and Electrodiagnostic Medicine (AANEM) guidelines and the Practice Parameter for Electrodiagnostic Studies in Carpal Tunnel Syndrome...
2015: Advanced Biomedical Research
https://www.readbyqxmd.com/read/25789931/aanem-s-top-five-choosing-wisely-recommendations
#15
REVIEW
(no author information available yet)
OBJECTIVE: To discuss the American Association of Neuromuscular & Electrodiagnostic Medicine (AANEM)'s Top Five Recommendations in the Choosing Wisely campaign educating physicians and patients on high quality electrodiagnostic and neuromuscular medicine. The AANEM published its Top Five Recommendations in February 2015 in collaboration with the American Board of Internal Medicine Foundation and Consumer Reports. METHODS: The Professional Practice Committee (PPC) of the American Association of Neuromuscular & Electrodiagnostic Medicine (AANEM) developed this list of recommendations...
April 2015: Muscle & Nerve
https://www.readbyqxmd.com/read/25715573/-the-duration-of-the-symptoms-of-carpal-tunnel-syndrome-to-the-diagnosis
#16
Marta A Durka-Kesy, Zanna Pastuszak, Kazimierz Tomczykiewicz, Marzena Maciagowska-Terela, Adam Stepień
UNLABELLED: Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy. Efficacy of the surgical treatment is dependent on the severity of median nerve injury. THE AIM OF STUDY: To determine the average duration of symptoms to diagnosis CTS. MATERIAL AND METHODS: Survey study conceming the duration of symptoms of CTS to establishing the diagnosis was conducted between 192 consecutive patients with CTS referred to the Electrophysiology Laboratory of the Military Institute of Medicine for the confirmatory EMG testing...
December 2014: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/25540801/endomicroscopy-and-electromyography-of-neuromuscular-junctions-in-situ
#17
Rosalind Brown, Kosala N Dissanayake, Paul A Skehel, Richard R Ribchester
OBJECTIVE: Electromyography (EMG) is used routinely to diagnose neuromuscular dysfunction in a wide range of peripheral neuropathies, myopathies, and neuromuscular degenerative diseases including motor neuron diseases such as amyotrophic lateral sclerosis (ALS). Definitive neurological diagnosis may also be indicated by the analysis of pathological neuromuscular innervation in motor-point biopsies. Our objective in this study was to preempt motor-point biopsy by combining live imaging with electrophysiological analysis of slow degeneration of neuromuscular junctions (NMJs) in vivo...
November 2014: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/25530757/prevalence-of-gastroesophageal-reflux-disease-in-type-ii-diabetes-mellitus
#18
Huihui Sun, Lisha Yi, Ping Wu, Yingjie Li, Bin Luo, Shuchang Xu
Background/Aims. Patients with type II diabetes mellitus (DM) were known to have higher prevalence of gastroesophageal reflux disease (GERD) in the Western countries, but data on the impact of GERD on DM patients in our country are scarce. The aim of this study was to evaluate the prevalence of GERD in type II DM patients in Shanghai, China, and to explore its possible risk factors. Methods. 775 type II DM cases were randomly collected. Reflux Disease Questionnaire (RDQ) was used to check the presence of GERD...
2014: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/25309729/validation-of-the-peroneal-nerve-test-to-diagnose-critical-illness-polyneuropathy-and-myopathy-in-the-intensive-care-unit-the-multicentre-italian-crimyne-2-diagnostic-accuracy-study
#19
Nicola Latronico, Giovanni Nattino, Bruno Guarneri, Nazzareno Fagoni, Aldo Amantini, Guido Bertolini
OBJECTIVES: To evaluate the accuracy of the peroneal nerve test (PENT) in the diagnosis of critical illness polyneuropathy (CIP) and myopathy (CIM) in the intensive care unit (ICU). We hypothesised that abnormal reduction of peroneal compound muscle action potential (CMAP) amplitude predicts CIP/CIM diagnosed using a complete nerve conduction study and electromyography (NCS-EMG) as a reference diagnostic standard. DESIGN: prospective observational study. SETTING: Nine Italian ICUs...
2014: F1000Research
https://www.readbyqxmd.com/read/25257857/muscle-mri-stir-signal-intensity-and-atrophy-are-correlated-to-focal-lower-limb-neuropathy-severity
#20
N Deroide, V Bousson, L Mambre, E Vicaut, J D Laredo, Nathalie Kubis
OBJECTIVES: The objective is to determine if muscle MRI is useful for assessing neuropathy severity. METHODS: Clinical, MRI and electromyography (EMG) examinations were performed in 17 patients with focal lower limb neuropathies. MRI Short Tau Inversion Recovery (STIR) signal intensity, amyotrophy, and muscle fatty infiltration measured after T1-weighted image acquisition, EMG spontaneous activity (SA), and maximal voluntary contraction (MVC) were graded using semiquantitative scores and quantitative scores for STIR signal intensity and were correlated to the Medical Research Council (MRC) score for testing muscle strength...
March 2015: European Radiology
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